FOXA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ethanol oxidation (GO:0006069)6.46008249
2dopaminergic neuron differentiation (GO:0071542)6.18424985
3L-phenylalanine catabolic process (GO:0006559)5.67482297
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.67482297
5biotin metabolic process (GO:0006768)5.65559676
6sulfur amino acid catabolic process (GO:0000098)5.64081292
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.36558751
8L-phenylalanine metabolic process (GO:0006558)5.36558751
9prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.30953816
10axonemal dynein complex assembly (GO:0070286)5.28721952
11urea cycle (GO:0000050)5.24390599
12urea metabolic process (GO:0019627)5.24390599
13branching involved in prostate gland morphogenesis (GO:0060442)5.22896924
14aromatic amino acid family catabolic process (GO:0009074)5.21969895
15ethanol metabolic process (GO:0006067)4.98232361
16kynurenine metabolic process (GO:0070189)4.92980876
17tryptophan catabolic process (GO:0006569)4.92011834
18indole-containing compound catabolic process (GO:0042436)4.92011834
19indolalkylamine catabolic process (GO:0046218)4.92011834
20nitrogen cycle metabolic process (GO:0071941)4.87708598
21ear development (GO:0043583)4.84191920
22negative regulation of sterol transport (GO:0032372)4.79106905
23negative regulation of cholesterol transport (GO:0032375)4.79106905
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.75250357
25cysteine metabolic process (GO:0006534)4.73658974
26regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.72270434
27alkaloid metabolic process (GO:0009820)4.69034863
28bile acid and bile salt transport (GO:0015721)4.62622734
29serine family amino acid catabolic process (GO:0009071)4.59696145
30tryptophan metabolic process (GO:0006568)4.56091316
31iron ion import (GO:0097286)4.53355029
32bile acid biosynthetic process (GO:0006699)4.52133225
33high-density lipoprotein particle remodeling (GO:0034375)4.51068160
34glyoxylate metabolic process (GO:0046487)4.50641625
35negative regulation of fibrinolysis (GO:0051918)4.49138043
36alpha-linolenic acid metabolic process (GO:0036109)4.46274565
37pyrimidine nucleobase catabolic process (GO:0006208)4.39887364
38* regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.28877889
39homocysteine metabolic process (GO:0050667)4.24328014
40regulation of protein activation cascade (GO:2000257)4.23990918
41COPI coating of Golgi vesicle (GO:0048205)4.23004390
42Golgi transport vesicle coating (GO:0048200)4.23004390
43desmosome organization (GO:0002934)4.20367750
44bile acid metabolic process (GO:0008206)4.17293419
45regulation of fibrinolysis (GO:0051917)4.15972515
46complement activation, alternative pathway (GO:0006957)4.10969917
47aromatic amino acid family metabolic process (GO:0009072)4.10630492
48* epithelial cell maturation (GO:0002070)4.07306463
49protein carboxylation (GO:0018214)4.06693144
50peptidyl-glutamic acid carboxylation (GO:0017187)4.06693144
51tyrosine metabolic process (GO:0006570)4.00930612
52regulation of cell proliferation involved in kidney development (GO:1901722)4.00592986
53coenzyme catabolic process (GO:0009109)3.99338912
54positive regulation of keratinocyte differentiation (GO:0045618)3.98381198
55regulation of complement activation (GO:0030449)3.97670679
56indolalkylamine metabolic process (GO:0006586)3.96323519
57vitamin transmembrane transport (GO:0035461)3.96270218
58positive regulation of cellular amine metabolic process (GO:0033240)3.93611786
59reverse cholesterol transport (GO:0043691)3.92477066
60cellular ketone body metabolic process (GO:0046950)3.92409880
61regulation of fatty acid beta-oxidation (GO:0031998)3.88235198
62branching involved in mammary gland duct morphogenesis (GO:0060444)3.86496077
63cilium or flagellum-dependent cell motility (GO:0001539)3.86314502
64apical protein localization (GO:0045176)3.85763370
65embryonic camera-type eye morphogenesis (GO:0048596)3.84187162
66maternal placenta development (GO:0001893)3.83840363
67regulation of bile acid biosynthetic process (GO:0070857)3.79747239
68motile cilium assembly (GO:0044458)3.78058695
69regulation of triglyceride catabolic process (GO:0010896)3.76350634
70regulation of water loss via skin (GO:0033561)3.75361099
71acylglycerol homeostasis (GO:0055090)3.73680570
72triglyceride homeostasis (GO:0070328)3.73680570
73benzene-containing compound metabolic process (GO:0042537)3.73423005
74insulin-like growth factor receptor signaling pathway (GO:0048009)3.71981124
75arginine metabolic process (GO:0006525)3.67275917
76protein-lipid complex remodeling (GO:0034368)3.66250971
77macromolecular complex remodeling (GO:0034367)3.66250971
78plasma lipoprotein particle remodeling (GO:0034369)3.66250971
79glycine metabolic process (GO:0006544)3.64285579
80positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.62540528
81flavonoid metabolic process (GO:0009812)3.61003339
82endothelial cell chemotaxis (GO:0035767)3.60759549
83nucleobase catabolic process (GO:0046113)3.59800704
84cilium movement (GO:0003341)3.59770616
85cellular glucuronidation (GO:0052695)3.59540583
86primary alcohol catabolic process (GO:0034310)3.58045304
87alpha-amino acid catabolic process (GO:1901606)3.57963393
88UDP-N-acetylglucosamine metabolic process (GO:0006047)3.53892088
89embryonic eye morphogenesis (GO:0048048)3.52749882
90cellular amino acid catabolic process (GO:0009063)3.51304573
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50727497
92regulation of cholesterol esterification (GO:0010872)3.49250762
93regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.48872218
94midgut development (GO:0007494)3.48694186
95regulation of cholesterol homeostasis (GO:2000188)3.48406650
96cholesterol efflux (GO:0033344)3.48197639
97cellular modified amino acid catabolic process (GO:0042219)3.47754597
98drug catabolic process (GO:0042737)3.45214523
99amino-acid betaine metabolic process (GO:0006577)3.45050981
100peptidyl-tyrosine autophosphorylation (GO:0038083)3.44534534
101lysine metabolic process (GO:0006553)3.42204366
102lysine catabolic process (GO:0006554)3.42204366
103regulation of cholesterol biosynthetic process (GO:0045540)3.40867326
104embryonic retina morphogenesis in camera-type eye (GO:0060059)3.40506254
105uterus development (GO:0060065)3.40126029
106multicellular organismal water homeostasis (GO:0050891)3.39865317
107glucuronate metabolic process (GO:0019585)3.38117533
108uronic acid metabolic process (GO:0006063)3.38117533
109mammary gland epithelial cell differentiation (GO:0060644)3.36726419
110serine family amino acid metabolic process (GO:0009069)3.36695102
111proline biosynthetic process (GO:0006561)3.35700065
112response to nitrosative stress (GO:0051409)3.35563056
113aldehyde catabolic process (GO:0046185)3.34186178
114lung lobe morphogenesis (GO:0060463)3.33487576
115ketone body metabolic process (GO:1902224)3.33467995
116dopamine biosynthetic process (GO:0042416)3.31262972
117S-adenosylmethionine metabolic process (GO:0046500)3.31045991
118asymmetric protein localization (GO:0008105)3.30631960
119imidazole-containing compound metabolic process (GO:0052803)3.29216898
120establishment of apical/basal cell polarity (GO:0035089)3.29211671
121exocrine pancreas development (GO:0031017)3.27444988
122intestinal epithelial cell development (GO:0060576)3.23182957
123cellular biogenic amine catabolic process (GO:0042402)3.22225217
124amine catabolic process (GO:0009310)3.22225217
125positive regulation of fatty acid beta-oxidation (GO:0032000)3.21665098
126acetyl-CoA metabolic process (GO:0006084)3.21477681
127midbrain development (GO:0030901)3.21223771
128regulation of receptor binding (GO:1900120)3.21021422
129regulation of histone H3-K27 methylation (GO:0061085)3.20974925
130regulation of interleukin-13 production (GO:0032656)3.20185137
131phospholipid efflux (GO:0033700)3.19198478
132carnitine transmembrane transport (GO:1902603)3.17965981
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15373164
134negative regulation of lipase activity (GO:0060192)3.15363300
135columnar/cuboidal epithelial cell development (GO:0002066)3.14682779
136amyloid precursor protein catabolic process (GO:0042987)3.13663028
137lung epithelium development (GO:0060428)3.13060296
138carnitine transport (GO:0015879)3.12135153
139amino-acid betaine transport (GO:0015838)3.12135153
140diterpenoid biosynthetic process (GO:0016102)3.10457751
141xenobiotic catabolic process (GO:0042178)3.10445301
142calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.08771156
143water homeostasis (GO:0030104)3.08734740
144regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.07804923
145carnitine shuttle (GO:0006853)3.06171075
146regulation of plasminogen activation (GO:0010755)3.06145389
147positive regulation of epidermal cell differentiation (GO:0045606)3.04526903
148positive regulation of hormone metabolic process (GO:0032352)3.02922577
149lung secretory cell differentiation (GO:0061140)3.02421334
150cholesterol homeostasis (GO:0042632)3.00893259
151pharyngeal system development (GO:0060037)2.98859221
152carboxylic acid catabolic process (GO:0046395)2.97438422
153organic acid catabolic process (GO:0016054)2.97438422
154fibrinolysis (GO:0042730)2.97326190
155exogenous drug catabolic process (GO:0042738)2.97311882
156glutamate metabolic process (GO:0006536)2.97053311
157sterol homeostasis (GO:0055092)2.97030060
158pyrimidine-containing compound transmembrane transport (GO:0072531)2.96400550
159response to food (GO:0032094)2.93248783
160epithelial cell-cell adhesion (GO:0090136)2.92904596
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89940751
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89866103
163cellular response to antibiotic (GO:0071236)2.88879854
164quaternary ammonium group transport (GO:0015697)2.86906875
165regulation of glucose import in response to insulin stimulus (GO:2001273)2.85990943
166regulation of keratinocyte differentiation (GO:0045616)2.84500078
167negative regulation of cell size (GO:0045792)2.84229580
168cardiac right ventricle morphogenesis (GO:0003215)2.84016505
169establishment of skin barrier (GO:0061436)2.83260907
170tight junction assembly (GO:0070830)2.82471096
171face development (GO:0060324)2.82009129
172negative regulation of kidney development (GO:0090185)2.78764398
173regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.78141987
174negative regulation of cell fate commitment (GO:0010454)2.76465050
175regulation of interleukin-5 production (GO:0032674)2.74647520
176ectodermal placode formation (GO:0060788)2.71998573
177endocrine hormone secretion (GO:0060986)2.71197615
178establishment or maintenance of monopolar cell polarity (GO:0061339)2.70819014
179establishment of monopolar cell polarity (GO:0061162)2.70819014
180epithelial cilium movement (GO:0003351)2.68215230
181mesonephros development (GO:0001823)2.67623599
182ER overload response (GO:0006983)2.67558718
183regulation of mesenchymal cell apoptotic process (GO:2001053)2.67523980
184phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.67334507
185regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67059044
186branching involved in salivary gland morphogenesis (GO:0060445)2.66717953
187female genitalia development (GO:0030540)2.66126895
188bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65397139
189vagina development (GO:0060068)2.63664459
190proline metabolic process (GO:0006560)2.63552299
191COPII vesicle coating (GO:0048208)2.62760323
192norepinephrine metabolic process (GO:0042415)2.59693173
193semaphorin-plexin signaling pathway (GO:0071526)2.59661095
194trivalent inorganic anion homeostasis (GO:0072506)2.57488194
195phosphate ion homeostasis (GO:0055062)2.57488194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.69151333
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.12997524
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.33963306
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.06730555
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.69526191
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84184409
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64456537
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.45053023
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.12813160
10RACK7_27058665_Chip-Seq_MCF-7_Human3.08621733
11CLOCK_20551151_ChIP-Seq_293T_Human2.65791777
12* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.64759982
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61586576
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.53644872
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.49134063
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.45330064
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.32827679
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.28908953
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.27105695
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.01583789
21GATA4_25053715_ChIP-Seq_YYC3_Human1.99684421
22* ZNF263_19887448_ChIP-Seq_K562_Human1.88995238
23PKCTHETA_26484144_Chip-Seq_BREAST_Human1.86756322
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85303067
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82556303
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.81587712
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74731648
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73777697
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71308807
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71022266
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65658998
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61343049
33AR_21909140_ChIP-Seq_LNCAP_Human1.59125415
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57317131
35* SOX2_20726797_ChIP-Seq_SW620_Human1.56486239
36* KDM5A_27292631_Chip-Seq_BREAST_Human1.54482369
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54204397
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51788295
39AHR_22903824_ChIP-Seq_MCF-7_Human1.49272531
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.48509126
41* ELF5_23300383_ChIP-Seq_T47D_Human1.48480233
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44649719
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44386339
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41589717
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40695740
46LXR_22292898_ChIP-Seq_THP-1_Human1.40569903
47* GATA6_25053715_ChIP-Seq_YYC3_Human1.36639711
48* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34485703
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30925956
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30888021
51TCF7_22412390_ChIP-Seq_EML_Mouse1.28284508
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27999945
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26783208
54SMC4_20622854_ChIP-Seq_HELA_Human1.26636677
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23527618
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23515660
57KDM2B_26808549_Chip-Seq_K562_Human1.22928194
58* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21521145
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20894977
60* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19661455
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19031407
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17875528
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.16273811
64ZNF274_21170338_ChIP-Seq_K562_Hela1.16012685
65* ATF3_27146783_Chip-Seq_COLON_Human1.14971381
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14414451
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14117014
68* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11442592
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09799704
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09035640
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08618345
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.06161525
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05756012
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02650080
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02373793
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01921922
77CREB1_26743006_Chip-Seq_LNCaP_Human1.00654146
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.00302863
79* PIAS1_25552417_ChIP-Seq_VCAP_Human0.97420513
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96114924
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95054984
82P68_20966046_ChIP-Seq_HELA_Human0.94423917
83* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93280706
84KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92400188
85* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92351497
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.91988850
87* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91697989
88MYC_22102868_ChIP-Seq_BL_Human0.91378169
89* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91169636
90BCAT_22108803_ChIP-Seq_LS180_Human0.91042440
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90220276
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.89863405
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89802803
94* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89039073
95* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88898409
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88107628
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86309386
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.86125431
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85485004
100TET1_21451524_ChIP-Seq_MESCs_Mouse0.84705344
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84360342
102TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83909161
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83233466
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83233466
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83233466
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83102525
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82732596
108* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82263805
109* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82262919
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81552839
111XRN2_22483619_ChIP-Seq_HELA_Human0.81549387
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81160939
113* TP53_20018659_ChIP-ChIP_R1E_Mouse0.80883542
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80102566
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.79980315
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78590750
117AR_21572438_ChIP-Seq_LNCaP_Human0.77854221
118VDR_21846776_ChIP-Seq_THP-1_Human0.77799299
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77733312
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77733312
121KLF5_25053715_ChIP-Seq_YYC3_Human0.76945646
122* ISL1_27105846_Chip-Seq_CPCs_Mouse0.76571496
123HTT_18923047_ChIP-ChIP_STHdh_Human0.76383196
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76161307
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72802349
126* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72718448
127* CBX2_27304074_Chip-Seq_ESCs_Mouse0.70421573
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70346268
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.69313392
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.68808282
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68060332
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.67748465
133CHD1_26751641_Chip-Seq_LNCaP_Human0.67360917
134TAF15_26573619_Chip-Seq_HEK293_Human0.67074733
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66124984
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.65645582
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65246165
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65246165
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63826236
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.63697142
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62814173
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.59557660
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.59213041
144* RING1B_27294783_Chip-Seq_NPCs_Mouse0.58571543
145RXR_22108803_ChIP-Seq_LS180_Human0.58286999
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.58129277
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.56936233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21824393
2MP0005360_urolithiasis5.14044020
3MP0005365_abnormal_bile_salt4.98465277
4MP0005085_abnormal_gallbladder_physiolo4.96103087
5MP0008875_abnormal_xenobiotic_pharmacok4.48036757
6MP0002009_preneoplasia3.88492181
7MP0001346_abnormal_lacrimal_gland3.24908636
8MP0005083_abnormal_biliary_tract3.18695098
9MP0000537_abnormal_urethra_morphology3.07889628
10MP0009780_abnormal_chondrocyte_physiolo2.86814035
11MP0000566_synostosis2.80806974
12MP0001666_abnormal_nutrient_absorption2.79606985
13MP0000569_abnormal_digit_pigmentation2.70325424
14MP0003252_abnormal_bile_duct2.56597852
15MP0010234_abnormal_vibrissa_follicle2.54360329
16MP0002166_altered_tumor_susceptibility2.47570860
17MP0005076_abnormal_cell_differentiation2.47327561
18* MP0010329_abnormal_lipoprotein_level2.47262308
19MP0004858_abnormal_nervous_system2.30092992
20MP0003806_abnormal_nucleotide_metabolis2.24522685
21MP0000383_abnormal_hair_follicle2.21836438
22MP0004185_abnormal_adipocyte_glucose2.09528412
23MP0002249_abnormal_larynx_morphology2.07148108
24MP0003123_paternal_imprinting2.06609812
25MP0004233_abnormal_muscle_weight1.89769310
26MP0004264_abnormal_extraembryonic_tissu1.87792243
27MP0008004_abnormal_stomach_pH1.87066408
28MP0005332_abnormal_amino_acid1.84404506
29MP0005248_abnormal_Harderian_gland1.84377590
30MP0004019_abnormal_vitamin_homeostasis1.81330645
31MP0002822_catalepsy1.78320751
32MP0000462_abnormal_digestive_system1.73850238
33MP0003868_abnormal_feces_composition1.71966081
34MP0002138_abnormal_hepatobiliary_system1.69576337
35MP0000538_abnormal_urinary_bladder1.69236162
36MP0004782_abnormal_surfactant_physiolog1.61474422
37MP0009379_abnormal_foot_pigmentation1.58284068
38MP0005646_abnormal_pituitary_gland1.56398292
39MP0000609_abnormal_liver_physiology1.54831337
40MP0002006_tumorigenesis1.52784706
41* MP0000627_abnormal_mammary_gland1.51913330
42MP0005310_abnormal_salivary_gland1.50725153
43MP0009053_abnormal_anal_canal1.49180987
44MP0001919_abnormal_reproductive_system1.45297244
45MP0010030_abnormal_orbit_morphology1.41354706
46* MP0002118_abnormal_lipid_homeostasis1.38096284
47MP0009840_abnormal_foam_cell1.35482543
48MP0005319_abnormal_enzyme/_coenzyme1.34790388
49MP0005501_abnormal_skin_physiology1.34351326
50MP0002653_abnormal_ependyma_morphology1.33576638
51MP0005647_abnormal_sex_gland1.31817596
52MP0004381_abnormal_hair_follicle1.25077694
53MP0000678_abnormal_parathyroid_gland1.22128068
54MP0002160_abnormal_reproductive_system1.22012971
55MP0002089_abnormal_postnatal_growth/wei1.21613203
56MP0000613_abnormal_salivary_gland1.21006882
57MP0003283_abnormal_digestive_organ1.20813086
58MP0000377_abnormal_hair_follicle1.19221328
59MP0005187_abnormal_penis_morphology1.19001820
60MP0001664_abnormal_digestion1.18329274
61MP0001905_abnormal_dopamine_level1.17411420
62MP0002132_abnormal_respiratory_system1.17186652
63MP0005636_abnormal_mineral_homeostasis1.16054902
64MP0003941_abnormal_skin_development1.14541871
65MP0001727_abnormal_embryo_implantation1.10183100
66MP0005666_abnormal_adipose_tissue1.08982714
67MP0005408_hypopigmentation1.08387909
68MP0005381_digestive/alimentary_phenotyp1.07799802
69MP0009643_abnormal_urine_homeostasis1.07597723
70MP0005367_renal/urinary_system_phenotyp1.06992370
71MP0000516_abnormal_urinary_system1.06992370
72* MP0005220_abnormal_exocrine_pancreas1.01344716
73MP0009672_abnormal_birth_weight1.00595096
74MP0003315_abnormal_perineum_morphology0.99949690
75MP0008995_early_reproductive_senescence0.99418536
76* MP0003936_abnormal_reproductive_system0.99168731
77MP0002098_abnormal_vibrissa_morphology0.97450111
78MP0005409_darkened_coat_color0.95725278
79MP0003183_abnormal_peptide_metabolism0.94238065
80MP0003186_abnormal_redox_activity0.93376013
81MP0002277_abnormal_respiratory_mucosa0.92632832
82MP0003890_abnormal_embryonic-extraembry0.92363987
83MP0001764_abnormal_homeostasis0.89719296
84MP0001756_abnormal_urination0.89133317
85MP0001663_abnormal_digestive_system0.87759663
86MP0004145_abnormal_muscle_electrophysio0.87494968
87MP0000427_abnormal_hair_cycle0.85701636
88MP0006276_abnormal_autonomic_nervous0.85076775
89MP0002282_abnormal_trachea_morphology0.84868952
90MP0003943_abnormal_hepatobiliary_system0.84855381
91MP0001216_abnormal_epidermal_layer0.83860378
92MP0003937_abnormal_limbs/digits/tail_de0.83413691
93MP0003191_abnormal_cellular_cholesterol0.82871171
94MP0003693_abnormal_embryo_hatching0.81596502
95MP0002736_abnormal_nociception_after0.81339093
96MP0001299_abnormal_eye_distance/0.81318107
97MP0004133_heterotaxia0.80488996
98MP0002108_abnormal_muscle_morphology0.80432109
99MP0009703_decreased_birth_body0.80324205
100MP0002116_abnormal_craniofacial_bone0.80029563
101MP0003453_abnormal_keratinocyte_physiol0.80025438
102MP0009764_decreased_sensitivity_to0.79120661
103MP0005645_abnormal_hypothalamus_physiol0.79109828
104MP0002796_impaired_skin_barrier0.78030616
105MP0000762_abnormal_tongue_morphology0.76862081
106MP0001340_abnormal_eyelid_morphology0.76090462
107MP0003115_abnormal_respiratory_system0.75632687
108MP0010678_abnormal_skin_adnexa0.74661650
109MP0003011_delayed_dark_adaptation0.74594093
110MP0002111_abnormal_tail_morphology0.74549288
111MP0001873_stomach_inflammation0.74432756
112MP0003718_maternal_effect0.74090818
113MP0000534_abnormal_ureter_morphology0.74045114
114MP0005451_abnormal_body_composition0.73612681
115MP0002254_reproductive_system_inflammat0.73465543
116MP0002735_abnormal_chemical_nociception0.71827999
117MP0003942_abnormal_urinary_system0.71604213
118MP0002088_abnormal_embryonic_growth/wei0.71346724
119MP0003959_abnormal_lean_body0.71136924
120MP0003938_abnormal_ear_development0.71077416
121MP0003119_abnormal_digestive_system0.70320379
122MP0003656_abnormal_erythrocyte_physiolo0.70292463
123MP0003705_abnormal_hypodermis_morpholog0.69169911
124MP0002234_abnormal_pharynx_morphology0.68735946
125MP0004883_abnormal_blood_vessel0.68659416
126MP0002896_abnormal_bone_mineralization0.66578111
127MP0009384_cardiac_valve_regurgitation0.66132756
128MP0003984_embryonic_growth_retardation0.65235302
129MP0010386_abnormal_urinary_bladder0.65077431
130MP0005084_abnormal_gallbladder_morpholo0.64874743
131MP0008961_abnormal_basal_metabolism0.64367297
132MP0001765_abnormal_ion_homeostasis0.64172327
133MP0005448_abnormal_energy_balance0.63552373
134MP0002092_abnormal_eye_morphology0.61244490
135MP0000598_abnormal_liver_morphology0.61146186
136MP0003638_abnormal_response/metabolism_0.59884308
137MP0001529_abnormal_vocalization0.59510661
138MP0005376_homeostasis/metabolism_phenot0.58841378
139MP0002697_abnormal_eye_size0.58405821
140MP0002876_abnormal_thyroid_physiology0.57013912
141MP0003880_abnormal_central_pattern0.56734008
142MP0000470_abnormal_stomach_morphology0.55606068
143MP0000579_abnormal_nail_morphology0.55271261
144MP0005197_abnormal_uvea_morphology0.54937276
145MP0005584_abnormal_enzyme/coenzyme_acti0.54178029
146MP0008872_abnormal_physiological_respon0.52726946
147MP0000477_abnormal_intestine_morphology0.52133068
148MP0000467_abnormal_esophagus_morphology0.50870099
149* MP0009642_abnormal_blood_homeostasis0.49996673
150MP0001881_abnormal_mammary_gland0.47041444
151MP0000647_abnormal_sebaceous_gland0.46947862
152MP0005395_other_phenotype0.45490004
153MP0002136_abnormal_kidney_physiology0.44982321
154* MP0001944_abnormal_pancreas_morphology0.44914750

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.11227061
2Intrahepatic cholestasis (HP:0001406)5.81659495
3Concave nail (HP:0001598)5.67135925
4Hypobetalipoproteinemia (HP:0003563)5.66019862
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.47379804
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.32427621
7Septate vagina (HP:0001153)5.31267600
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.17225614
9Prolonged partial thromboplastin time (HP:0003645)5.12283276
10Hyperglycinemia (HP:0002154)5.12051640
11Sparse lateral eyebrow (HP:0005338)4.99342819
12Hyperglycinuria (HP:0003108)4.80398331
13Flat acetabular roof (HP:0003180)4.50581392
14Xanthomatosis (HP:0000991)4.43904921
15Abnormality of glycine metabolism (HP:0010895)4.34355580
16Abnormality of serine family amino acid metabolism (HP:0010894)4.34355580
17Abnormal respiratory epithelium morphology (HP:0012253)4.26432712
18Abnormal respiratory motile cilium morphology (HP:0005938)4.26432712
19Fat malabsorption (HP:0002630)4.23759550
20Abnormal respiratory motile cilium physiology (HP:0012261)4.23516233
21Complement deficiency (HP:0004431)4.21192874
22Chronic bronchitis (HP:0004469)4.07633048
23Dynein arm defect of respiratory motile cilia (HP:0012255)4.06743443
24Absent/shortened dynein arms (HP:0200106)4.06743443
25Testicular atrophy (HP:0000029)4.06425282
26Rhinitis (HP:0012384)3.99251842
27Abnormal ciliary motility (HP:0012262)3.96125388
28Gout (HP:0001997)3.85582029
29Hypolipoproteinemia (HP:0010981)3.81645564
30Anterior segment dysgenesis (HP:0007700)3.68500250
31Conjugated hyperbilirubinemia (HP:0002908)3.59549817
32Hyperlipoproteinemia (HP:0010980)3.58072354
33Abnormality of the intrinsic pathway (HP:0010989)3.56764820
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.51645453
35Ileus (HP:0002595)3.38958927
36Lip pit (HP:0100267)3.34978038
37Steatorrhea (HP:0002570)3.30884618
38Hyperammonemia (HP:0001987)3.29542257
39Abnormality of the common coagulation pathway (HP:0010990)3.29374258
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23256165
41Germ cell neoplasia (HP:0100728)3.22092561
42Asymmetry of the thorax (HP:0001555)3.20342316
43Broad face (HP:0000283)3.14540311
44Abnormality of sulfur amino acid metabolism (HP:0004339)3.12751097
45Ketosis (HP:0001946)3.08294621
46Joint hemorrhage (HP:0005261)3.04402624
47Testicular neoplasm (HP:0010788)3.04227050
48Right ventricular cardiomyopathy (HP:0011663)2.98532842
49Epidermoid cyst (HP:0200040)2.97455714
50Malnutrition (HP:0004395)2.94766929
51Hypoalphalipoproteinemia (HP:0003233)2.90311270
52Abnormality of the distal phalanges of the toes (HP:0010182)2.89679224
53Abnormality of complement system (HP:0005339)2.89046395
54Abnormality of serum amino acid levels (HP:0003112)2.79798315
55Bronchiectasis (HP:0002110)2.72203871
56Amelogenesis imperfecta (HP:0000705)2.72184163
57Abnormality of purine metabolism (HP:0004352)2.64184996
58Glomerulonephritis (HP:0000099)2.63550794
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.62520062
60Abnormality of the proximal phalanges of the hand (HP:0009834)2.62503592
61Hypercholesterolemia (HP:0003124)2.61444247
62Limb dystonia (HP:0002451)2.57531194
63Abnormality of nucleobase metabolism (HP:0010932)2.54365610
64Anal stenosis (HP:0002025)2.52557835
65Abnormality of carpal bone ossification (HP:0006257)2.50609676
66Abnormality of fatty-acid metabolism (HP:0004359)2.50111916
67Macroorchidism (HP:0000053)2.49747343
68J-shaped sella turcica (HP:0002680)2.49260751
69Esophageal varix (HP:0002040)2.47814187
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46672511
71Spontaneous abortion (HP:0005268)2.44237462
72Spinal cord compression (HP:0002176)2.44166187
73Absent frontal sinuses (HP:0002688)2.43145792
74Polar cataract (HP:0010696)2.41491254
75Short nail (HP:0001799)2.40766263
76Abnormal cartilage morphology (HP:0002763)2.40262067
77Hepatocellular carcinoma (HP:0001402)2.36829209
78Abnormality of pyrimidine metabolism (HP:0004353)2.34726839
79Hypoparathyroidism (HP:0000829)2.33148791
80Infertility (HP:0000789)2.31865655
81Hyperactive renin-angiotensin system (HP:0000841)2.31856715
82Curly hair (HP:0002212)2.31263396
83Vascular calcification (HP:0004934)2.31146970
84Abnormality of the axillary hair (HP:0100134)2.29027402
85Abnormality of secondary sexual hair (HP:0009888)2.29027402
86Facial shape deformation (HP:0011334)2.27535995
87Potter facies (HP:0002009)2.27535995
88Abnormality of the phalanges of the hallux (HP:0010057)2.27112922
89Lethargy (HP:0001254)2.26786409
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25540154
91Congenital glaucoma (HP:0001087)2.25289365
92Bifid scrotum (HP:0000048)2.24170916
93Depressed nasal tip (HP:0000437)2.23410095
94Onycholysis (HP:0001806)2.22053863
95Hyperacusis (HP:0010780)2.22036596
96Thin bony cortex (HP:0002753)2.20326156
97Flattened epiphyses (HP:0003071)2.19332425
98Breast carcinoma (HP:0003002)2.16436760
99Abnormality of the dental root (HP:0006486)2.14653636
100Taurodontia (HP:0000679)2.14653636
101Abnormality of permanent molar morphology (HP:0011071)2.14653636
102Abnormal hand bone ossification (HP:0010660)2.12704740
103Nasal polyposis (HP:0100582)2.12412235
104Hyperuricemia (HP:0002149)2.11835656
105Increased purine levels (HP:0004368)2.11835656
106Abnormality of the nasal septum (HP:0000419)2.10121496
107Ketoacidosis (HP:0001993)2.10074447
108Abnormal ossification of hand bones (HP:0005921)2.09445620
109Spastic diplegia (HP:0001264)2.09299734
110Abnormality of the 1st metacarpal (HP:0010009)2.04238309
111Aplasia of the musculature (HP:0100854)2.03871025
112Metabolic acidosis (HP:0001942)2.03794136
113Abnormal pancreas size (HP:0012094)2.03077228
114Abnormal tarsal ossification (HP:0008369)2.00024412
115Short 1st metacarpal (HP:0010034)1.99908747
116Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99908747
117Hyperbilirubinemia (HP:0002904)1.97900515
118Irritability (HP:0000737)1.97287885
119Bronchomalacia (HP:0002780)1.96566759
120Cardiovascular calcification (HP:0011915)1.96195428
121Gonadotropin excess (HP:0000837)1.95383824
122Cone-rod dystrophy (HP:0000548)1.95231135
123Abnormality of the frontal sinuses (HP:0002687)1.93863775
124Abnormality of methionine metabolism (HP:0010901)1.93425342
125Congenital, generalized hypertrichosis (HP:0004540)1.91885497
126Microglossia (HP:0000171)1.91639504
127Advanced eruption of teeth (HP:0006288)1.90382684
128Partial duplication of thumb phalanx (HP:0009944)1.90288790
129Growth hormone excess (HP:0000845)1.90281137
130Abnormality of the fingertips (HP:0001211)1.90228624
131Abnormality of the gastric mucosa (HP:0004295)1.90027380
132Calf muscle hypertrophy (HP:0008981)1.88698635
133Morphological abnormality of the inner ear (HP:0011390)1.88303427
134Pili torti (HP:0003777)1.87636273
135Obstructive sleep apnea (HP:0002870)1.87610269
136Abnormality of molar (HP:0011077)1.87436903
137Abnormality of molar morphology (HP:0011070)1.87436903
138Abnormality of the parathyroid morphology (HP:0011766)1.87267156
139Microretrognathia (HP:0000308)1.87013850
140Hyperparathyroidism (HP:0000843)1.86925068
141Recurrent otitis media (HP:0000403)1.86883411
142Acanthocytosis (HP:0001927)1.86721084
143Hypoglycemic coma (HP:0001325)1.85829122
144Abnormal foot bone ossification (HP:0010675)1.85070809
145Abnormality of proline metabolism (HP:0010907)1.84589812
146Hydroxyprolinuria (HP:0003080)1.84589812
147Micronodular cirrhosis (HP:0001413)1.83200825
148Abnormality of the dental pulp (HP:0006479)1.82987620
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82757153
15011 pairs of ribs (HP:0000878)1.82563972
151Nephritis (HP:0000123)1.81834736
152Broad nasal tip (HP:0000455)1.81533145
153Prostate neoplasm (HP:0100787)1.81332214
154Cervical subluxation (HP:0003308)1.80482054
155Self-mutilation (HP:0000742)1.79552008
156Azoospermia (HP:0000027)1.79374463
157Insidious onset (HP:0003587)1.77104364
158Termporal pattern (HP:0011008)1.77104364
159Glomerulosclerosis (HP:0000096)1.77076177
160Hypoplasia of the uterus (HP:0000013)1.76063508
161Hyperkalemia (HP:0002153)1.76036551
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76009465
163Pancreatitis (HP:0001733)1.75956902
164Brushfield spots (HP:0001088)1.75683501
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74612006
166Hemorrhage of the eye (HP:0011885)1.74491611
167Skin nodule (HP:0200036)1.74443752
168Exostoses (HP:0100777)1.74219297
169Short femoral neck (HP:0100864)1.74190766
170Atelectasis (HP:0100750)1.73319134
171Long toe (HP:0010511)1.72882628
172Menorrhagia (HP:0000132)1.72635164
173Aplasia/hypoplasia of the femur (HP:0005613)1.72626993
174Short phalanx of the thumb (HP:0009660)1.72449219
175Neonatal hypoglycemia (HP:0001998)1.69619004
176Cerebral edema (HP:0002181)1.68579253
177Glycosuria (HP:0003076)1.68218845
178Abnormality of urine glucose concentration (HP:0011016)1.68218845
179Abdominal distention (HP:0003270)1.67960455
180Delayed CNS myelination (HP:0002188)1.67128690
181Biliary tract neoplasm (HP:0100574)1.66843908
182Abnormality of the anterior chamber (HP:0000593)1.66683607
183Hyperglycemia (HP:0003074)1.66682690
184Hypochromic microcytic anemia (HP:0004840)1.64701445
185Back pain (HP:0003418)1.64682706
186Respiratory distress (HP:0002098)1.64026134
187Abnormality of chloride homeostasis (HP:0011422)1.63619073
188Aplasia/Hypoplasia involving the musculature (HP:0001460)1.63474714
189Late onset (HP:0003584)1.62548624
190Abnormal biliary tract morphology (HP:0012440)1.62098239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.92735517
2EPHA23.63972959
3EPHB23.53038266
4ERN13.26427407
5PKN23.17054563
6AKT33.16468942
7BCKDK3.03725179
8SIK12.97669439
9TAOK12.89240958
10FRK2.79326114
11MST1R2.78911015
12TAOK32.62398885
13MST42.58396135
14SMG12.57107733
15TNK22.54971124
16MAPKAPK32.40728386
17STK392.38764391
18KSR12.35805258
19PRKD32.32800507
20MAPK152.32448721
21SCYL22.26220214
22MAP2K22.12287821
23ERBB42.12283198
24LMTK22.10395711
25ERBB22.05080697
26NUAK11.85380969
27BCR1.76765800
28CSNK1G31.70916470
29MUSK1.70250494
30SIK31.64990042
31DYRK1B1.62578509
32TESK11.60615069
33CSNK1G11.60116529
34DYRK31.59073033
35CDK121.56708535
36IRAK31.55535006
37PTK61.45921967
38MAP3K121.45056734
39PIM21.43714978
40STK38L1.38603965
41FGFR41.38036714
42STK31.37986007
43CSNK1G21.33187936
44CDK71.31480257
45PRKD21.25497518
46MARK11.24727104
47INSRR1.23006633
48EIF2AK11.18587844
49NEK61.17961880
50ERBB31.16832508
51DAPK21.14894105
52FGFR21.12394436
53MAP3K21.11604997
54FER1.09987878
55DYRK21.09037060
56OXSR11.05665487
57PTK21.05523978
58MYLK0.99945625
59LATS20.98195188
60MARK20.91809629
61TRIB30.90700026
62TESK20.88949498
63STK160.88133630
64RPS6KB20.87398985
65NME10.85448405
66BMPR1B0.84452032
67TGFBR10.84116078
68RPS6KA20.82990817
69ILK0.80751373
70MAP3K30.80362216
71MAP2K60.80238947
72YES10.80060934
73MAP2K10.78955321
74PAK40.74982463
75CSNK1A1L0.74879070
76IRAK20.74703125
77MAP2K40.73150582
78GRK60.72606375
79MET0.72566349
80NME20.69797576
81PAK30.66804946
82HIPK20.66205531
83TAF10.65557717
84MAPK130.65388100
85PIK3CG0.64103554
86PRKAA10.63770398
87PRKCI0.61107797
88PNCK0.60895111
89LRRK20.59576354
90EEF2K0.59210348
91AKT20.58829776
92RET0.58445681
93SRPK10.57802701
94RIPK10.57457072
95MELK0.57261517
96GSK3A0.56377748
97PRKCZ0.55318676
98RPS6KB10.54960220
99UHMK10.54447420
100VRK20.54104303
101PAK20.53937704
102PDPK10.53651554
103CSNK1E0.51491086
104DYRK1A0.50234631
105MAP3K90.48941683
106CDK60.47903669
107CAMKK10.46961207
108MAPK110.45400357
109RPS6KA10.44777967
110MAPK40.44586583
111ICK0.44456093
112RPS6KL10.44074342
113RPS6KC10.44074342
114BUB10.42281083
115CAMK1G0.40601380
116BRSK20.40372317
117SIK20.38492716
118PRKD10.38035042
119CAMK2B0.36881835
120STK380.36730393
121TSSK60.36464428
122RPS6KA60.35662489
123CHUK0.34276061
124CAMK2G0.33878581
125RPS6KA40.32379365
126AURKB0.31987965
127SGK30.31247815
128GRK10.30953190
129MAP3K110.30899560
130PRKAA20.30862252
131MINK10.28849009
132AURKA0.28505719
133JAK20.28235462
134MTOR0.27923437
135SGK4940.27678369
136SGK2230.27678369
137DMPK0.27451131
138TYK20.27283571
139MAPK80.26268303
140ADRBK10.24223568
141ROCK10.24210544
142MAPKAPK20.24014622
143SGK20.23873349
144WEE10.23373768
145BRSK10.22814791
146CSNK1A10.22292610
147PRKACG0.20458722
148MAPK140.20186272
149WNK40.19667997
150CAMK1D0.19304799
151TGFBR20.18977039
152GRK50.18798888
153PIK3CA0.18747239
154GSK3B0.18213344

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84122843
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29138723
3Sulfur metabolism_Homo sapiens_hsa009203.04598325
4Tryptophan metabolism_Homo sapiens_hsa003802.79988537
5Arginine biosynthesis_Homo sapiens_hsa002202.79626682
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.76028984
7Nitrogen metabolism_Homo sapiens_hsa009102.61333450
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.59025615
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46485612
10Fatty acid degradation_Homo sapiens_hsa000712.41363406
11Chemical carcinogenesis_Homo sapiens_hsa052042.35704719
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35306851
13Complement and coagulation cascades_Homo sapiens_hsa046102.26300470
14Histidine metabolism_Homo sapiens_hsa003402.24677664
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24346036
16Vitamin B6 metabolism_Homo sapiens_hsa007502.22274115
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18027334
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16288314
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08283151
20Butanoate metabolism_Homo sapiens_hsa006502.08141503
21Retinol metabolism_Homo sapiens_hsa008302.01129325
22Prostate cancer_Homo sapiens_hsa052151.95376311
23Thyroid cancer_Homo sapiens_hsa052161.83697008
24Phenylalanine metabolism_Homo sapiens_hsa003601.81653422
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80917853
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.80380364
27Propanoate metabolism_Homo sapiens_hsa006401.79199271
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77249070
29beta-Alanine metabolism_Homo sapiens_hsa004101.75413079
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72946558
31Tyrosine metabolism_Homo sapiens_hsa003501.71747812
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.69527290
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.69074640
34Notch signaling pathway_Homo sapiens_hsa043301.68989341
35Peroxisome_Homo sapiens_hsa041461.64345420
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.60756002
37PPAR signaling pathway_Homo sapiens_hsa033201.56892713
38Fat digestion and absorption_Homo sapiens_hsa049751.51256957
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50249067
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49321759
41Selenocompound metabolism_Homo sapiens_hsa004501.47538325
42Fatty acid metabolism_Homo sapiens_hsa012121.46969618
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.45001508
44mTOR signaling pathway_Homo sapiens_hsa041501.38824287
45Bile secretion_Homo sapiens_hsa049761.37858966
46Caffeine metabolism_Homo sapiens_hsa002321.36879823
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34294543
48Sulfur relay system_Homo sapiens_hsa041221.32643640
49Insulin signaling pathway_Homo sapiens_hsa049101.32580294
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31323199
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29984999
52Estrogen signaling pathway_Homo sapiens_hsa049151.29779993
53Glutathione metabolism_Homo sapiens_hsa004801.22786657
54ErbB signaling pathway_Homo sapiens_hsa040121.21405877
55Pyruvate metabolism_Homo sapiens_hsa006201.21313948
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18928551
57Acute myeloid leukemia_Homo sapiens_hsa052211.12262216
58Arginine and proline metabolism_Homo sapiens_hsa003301.11698340
59Choline metabolism in cancer_Homo sapiens_hsa052311.11182219
60Starch and sucrose metabolism_Homo sapiens_hsa005001.09781395
61Folate biosynthesis_Homo sapiens_hsa007901.08569529
62Non-small cell lung cancer_Homo sapiens_hsa052231.04503908
63Sphingolipid metabolism_Homo sapiens_hsa006001.02125021
64Staphylococcus aureus infection_Homo sapiens_hsa051500.98542507
65Hepatitis C_Homo sapiens_hsa051600.98348600
66Chronic myeloid leukemia_Homo sapiens_hsa052200.97671044
67Vitamin digestion and absorption_Homo sapiens_hsa049770.94350716
68Renal cell carcinoma_Homo sapiens_hsa052110.93843628
69VEGF signaling pathway_Homo sapiens_hsa043700.92975138
70Glucagon signaling pathway_Homo sapiens_hsa049220.92062959
71Vibrio cholerae infection_Homo sapiens_hsa051100.91349584
72ABC transporters_Homo sapiens_hsa020100.89607902
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.89105062
74Steroid biosynthesis_Homo sapiens_hsa001000.88278490
75Biosynthesis of amino acids_Homo sapiens_hsa012300.87934112
76N-Glycan biosynthesis_Homo sapiens_hsa005100.84876249
77Carbon metabolism_Homo sapiens_hsa012000.83485689
78Fatty acid elongation_Homo sapiens_hsa000620.81274899
79Lysine degradation_Homo sapiens_hsa003100.79828327
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79097337
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78235261
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78038937
83Prolactin signaling pathway_Homo sapiens_hsa049170.74951584
84Ovarian steroidogenesis_Homo sapiens_hsa049130.67765461
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65215267
86Glycerolipid metabolism_Homo sapiens_hsa005610.63864943
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62942391
88Type II diabetes mellitus_Homo sapiens_hsa049300.60325257
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55249065
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52462486
91Proteoglycans in cancer_Homo sapiens_hsa052050.52238651
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51169451
93TGF-beta signaling pathway_Homo sapiens_hsa043500.50095683
94Metabolic pathways_Homo sapiens_hsa011000.48622042
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48167160
96mRNA surveillance pathway_Homo sapiens_hsa030150.48153980
97Bladder cancer_Homo sapiens_hsa052190.47753555
98Inositol phosphate metabolism_Homo sapiens_hsa005620.47251370
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46605174
100Renin-angiotensin system_Homo sapiens_hsa046140.45526016
101Melanogenesis_Homo sapiens_hsa049160.45452319
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44756465
103Melanoma_Homo sapiens_hsa052180.43228214
104Axon guidance_Homo sapiens_hsa043600.42939167
105Pancreatic cancer_Homo sapiens_hsa052120.41564688
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41267025
107Glioma_Homo sapiens_hsa052140.40998963
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40050610
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39612559
110Gap junction_Homo sapiens_hsa045400.39165476
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.38956826
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.36524375
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36124425
114Pentose phosphate pathway_Homo sapiens_hsa000300.36066271
115Cocaine addiction_Homo sapiens_hsa050300.35624392
116Fructose and mannose metabolism_Homo sapiens_hsa000510.35594977
117Fatty acid biosynthesis_Homo sapiens_hsa000610.33158965
118Mineral absorption_Homo sapiens_hsa049780.32379301
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28337633
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26665871
121Hippo signaling pathway_Homo sapiens_hsa043900.25313778
122Prion diseases_Homo sapiens_hsa050200.24526834
123Tight junction_Homo sapiens_hsa045300.23821839
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19906818
125Basal cell carcinoma_Homo sapiens_hsa052170.19753589
126Insulin resistance_Homo sapiens_hsa049310.16993007
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16140852
128AMPK signaling pathway_Homo sapiens_hsa041520.14303988
129Galactose metabolism_Homo sapiens_hsa000520.11786463
130Endometrial cancer_Homo sapiens_hsa052130.11725231
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11232144
132Linoleic acid metabolism_Homo sapiens_hsa005910.10939412
133Thyroid hormone synthesis_Homo sapiens_hsa049180.10619462
134Regulation of autophagy_Homo sapiens_hsa041400.10112339
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10035633
136Protein export_Homo sapiens_hsa030600.09616622
137Adherens junction_Homo sapiens_hsa045200.09542026
138Amoebiasis_Homo sapiens_hsa051460.07786563
139Small cell lung cancer_Homo sapiens_hsa052220.04626334
140Circadian rhythm_Homo sapiens_hsa047100.03548417
141One carbon pool by folate_Homo sapiens_hsa006700.03394335
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.03319530
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02810310

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