FOSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)5.86622799
2response to peptidoglycan (GO:0032494)4.68986405
3cell migration involved in sprouting angiogenesis (GO:0002042)4.21352152
4positive regulation of p38MAPK cascade (GO:1900745)3.93386436
5regulation of gamma-delta T cell differentiation (GO:0045586)3.90527211
6regulation of interleukin-12 biosynthetic process (GO:0045075)3.81096059
7regulation of p38MAPK cascade (GO:1900744)3.76296545
8regulation of gamma-delta T cell activation (GO:0046643)3.73581746
9negative regulation of erythrocyte differentiation (GO:0045647)3.67825172
10detection of molecule of bacterial origin (GO:0032490)3.61462430
11negative regulation of interleukin-12 production (GO:0032695)3.60884950
12macrophage activation involved in immune response (GO:0002281)3.52550200
13tolerance induction (GO:0002507)3.49458461
14cellular extravasation (GO:0045123)3.47603321
15neutrophil activation involved in immune response (GO:0002283)3.39913960
16cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.33009206
17detection of other organism (GO:0098543)3.29339215
18response to muramyl dipeptide (GO:0032495)3.27968817
19interferon-gamma production (GO:0032609)3.27850707
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27474372
21JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25595516
22blood vessel endothelial cell migration (GO:0043534)3.25151462
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.24183978
24negative regulation of fatty acid transport (GO:2000192)3.20417186
25regulation of vitamin D biosynthetic process (GO:0060556)3.15036410
26regulation of T-helper 2 cell differentiation (GO:0045628)3.12762622
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11833795
28detection of external biotic stimulus (GO:0098581)3.07113563
29detection of bacterium (GO:0016045)2.98462633
30growth hormone receptor signaling pathway (GO:0060396)2.96271210
31lung lobe morphogenesis (GO:0060463)2.94995222
32positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94363348
33tyrosine phosphorylation of STAT protein (GO:0007260)2.93751315
34skin morphogenesis (GO:0043589)2.91133939
35positive thymic T cell selection (GO:0045059)2.90079860
36regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87696340
37detection of biotic stimulus (GO:0009595)2.87588563
38NIK/NF-kappaB signaling (GO:0038061)2.87353931
39positive regulation of heat generation (GO:0031652)2.82064951
40hemidesmosome assembly (GO:0031581)2.81523288
41regulation of fever generation (GO:0031620)2.81398227
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79344824
43response to laminar fluid shear stress (GO:0034616)2.78150403
44regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.75544556
45CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.75266280
46T-helper cell differentiation (GO:0042093)2.75266280
47mannose metabolic process (GO:0006013)2.75192784
48macrophage activation (GO:0042116)2.74533294
49mesodermal cell differentiation (GO:0048333)2.72380830
50response to interleukin-15 (GO:0070672)2.71206086
51negative regulation of interleukin-8 production (GO:0032717)2.70585376
52regulation of T cell tolerance induction (GO:0002664)2.69622737
53cell adhesion mediated by integrin (GO:0033627)2.67695661
54cellular response to growth hormone stimulus (GO:0071378)2.66583341
55regulation of membrane protein ectodomain proteolysis (GO:0051043)2.66367222
56positive regulation of astrocyte differentiation (GO:0048711)2.65226199
57thymic T cell selection (GO:0045061)2.63940759
58regulation of vitamin metabolic process (GO:0030656)2.62515016
59T-helper 1 type immune response (GO:0042088)2.62342212
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60762033
61negative regulation of cytokine production involved in immune response (GO:0002719)2.60157650
62granulocyte activation (GO:0036230)2.59816923
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59002903
64protein heterotrimerization (GO:0070208)2.58914581
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58328947
66regulation of interferon-beta biosynthetic process (GO:0045357)2.58230197
67pinocytosis (GO:0006907)2.57496597
68positive regulation of gamma-delta T cell activation (GO:0046645)2.54212880
69regulation of leukocyte degranulation (GO:0043300)2.52508306
70antigen processing and presentation of endogenous antigen (GO:0019883)2.51631762
71positive regulation of cellular amide metabolic process (GO:0034250)2.50957447
72regulation of interleukin-8 biosynthetic process (GO:0045414)2.49533914
73substrate-dependent cell migration (GO:0006929)2.47681104
74regulation of mast cell degranulation (GO:0043304)2.47019377
75positive regulation of chemokine biosynthetic process (GO:0045080)2.46976350
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.46941009
77neutrophil activation (GO:0042119)2.45226981
78interleukin-1-mediated signaling pathway (GO:0070498)2.44632314
79positive regulation of type 2 immune response (GO:0002830)2.44034917
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43514719
81germ cell migration (GO:0008354)2.42219174
82decidualization (GO:0046697)2.42064732
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39067949
84response to host (GO:0075136)2.39067949
85response to host defenses (GO:0052200)2.39067949
86defense response to protozoan (GO:0042832)2.38707518
87regulation of type 2 immune response (GO:0002828)2.38219533
88response to protozoan (GO:0001562)2.37993977
89neutrophil mediated immunity (GO:0002446)2.37706414
90positive T cell selection (GO:0043368)2.37059645
91negative regulation of interleukin-6 production (GO:0032715)2.36674540
92positive regulation of macrophage differentiation (GO:0045651)2.35957063
93myeloid dendritic cell differentiation (GO:0043011)2.35376383
94alpha-beta T cell differentiation involved in immune response (GO:0002293)2.34652887
95alpha-beta T cell activation involved in immune response (GO:0002287)2.34652887
96T cell differentiation involved in immune response (GO:0002292)2.34652887
97cellular response to interleukin-15 (GO:0071350)2.34399551
98apoptotic cell clearance (GO:0043277)2.34160311
99cellular response to thyroid hormone stimulus (GO:0097067)2.33794108
100regulation of T-helper 1 cell differentiation (GO:0045625)2.33084891
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32594441
102regulation of chemokine biosynthetic process (GO:0045073)2.32591854
103regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32401167
104response to fluid shear stress (GO:0034405)2.32360684
105leukocyte aggregation (GO:0070486)2.32220242
106myeloid cell activation involved in immune response (GO:0002275)2.32185609
107positive regulation of tolerance induction (GO:0002645)2.32101117
108T cell selection (GO:0045058)2.31693724
109response to type I interferon (GO:0034340)2.31540144
110type I interferon signaling pathway (GO:0060337)2.31088678
111cellular response to type I interferon (GO:0071357)2.31088678
112wound healing, spreading of epidermal cells (GO:0035313)2.31030012
113positive regulation of bone resorption (GO:0045780)2.31029946
114positive regulation of bone remodeling (GO:0046852)2.31029946
115platelet-derived growth factor receptor signaling pathway (GO:0048008)2.30939443
116cellular response to epinephrine stimulus (GO:0071872)2.30763184
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.30392103
118positive regulation of natural killer cell differentiation (GO:0032825)2.30012529
119mRNA transcription (GO:0009299)2.29358915
120immunoglobulin mediated immune response (GO:0016064)2.29211033
121negative regulation of type 2 immune response (GO:0002829)2.27843663
122epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27729932
123regulation of podosome assembly (GO:0071801)2.27650684
124response to host immune response (GO:0052572)2.26743359
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.26743359
126embryonic process involved in female pregnancy (GO:0060136)2.25419939
127angiogenesis involved in wound healing (GO:0060055)2.24913613
128positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.24392870
129regulation of mast cell activation involved in immune response (GO:0033006)2.24379673
130regulation of heat generation (GO:0031650)2.23749091
131low-density lipoprotein particle clearance (GO:0034383)2.22779875
132endodermal cell differentiation (GO:0035987)2.22216953
133regulation of interleukin-6 production (GO:0032675)2.21993364
134positive regulation of osteoclast differentiation (GO:0045672)2.21892452
135negative regulation of toll-like receptor signaling pathway (GO:0034122)2.21677963
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.21648337
137negative regulation of T cell mediated immunity (GO:0002710)2.20790213
138regulation of macrophage cytokine production (GO:0010935)2.20195167
139establishment of endothelial barrier (GO:0061028)2.19931885
140vascular endothelial growth factor signaling pathway (GO:0038084)2.19655620
141face morphogenesis (GO:0060325)2.18761546
142positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18414636
143regulation of transforming growth factor beta1 production (GO:0032908)2.18108844
144mature B cell differentiation involved in immune response (GO:0002313)2.17889669
145protein localization to endosome (GO:0036010)2.17861314
146regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.17742664
147cellular response to lipopolysaccharide (GO:0071222)2.17642741
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.17323148
149cellular response to gonadotropin stimulus (GO:0071371)2.14890607
150regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.12762691
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.12650635
152negative regulation of cell killing (GO:0031342)2.12650635
153myeloid dendritic cell activation (GO:0001773)2.11416250
154negative thymic T cell selection (GO:0045060)2.11234145
155collagen fibril organization (GO:0030199)2.11209249
156chondrocyte proliferation (GO:0035988)2.11096950
157positive regulation by symbiont of host defense response (GO:0052509)2.10932304
158modulation by symbiont of host defense response (GO:0052031)2.10932304
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.10932304
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.10932304
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.10932304
162modulation by symbiont of host immune response (GO:0052553)2.10932304
163response to gonadotropin (GO:0034698)2.10899684
164cell-substrate junction assembly (GO:0007044)2.10718633
165entrainment of circadian clock by photoperiod (GO:0043153)2.06645744
166gland morphogenesis (GO:0022612)2.06132722
167leukocyte cell-cell adhesion (GO:0007159)2.05599407
168regulation of tolerance induction (GO:0002643)2.05322910
169germinal center formation (GO:0002467)2.05227030
170pathway-restricted SMAD protein phosphorylation (GO:0060389)2.05072626
171alpha-beta T cell differentiation (GO:0046632)2.04946472
172negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.04717760
173negative T cell selection (GO:0043383)2.04568312
174positive regulation of T cell differentiation in thymus (GO:0033089)2.04170008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.99658850
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.91410541
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.22700161
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.84027630
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.54685987
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.07139478
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.80947052
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61849276
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45410055
10CLOCK_20551151_ChIP-Seq_293T_Human2.40642320
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.30087328
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29077284
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.15965901
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15038098
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.12238058
16VDR_21846776_ChIP-Seq_THP-1_Human2.11082514
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11040154
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.08093302
19RUNX_20019798_ChIP-Seq_JUKART_Human2.06551304
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01954978
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87569152
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87563376
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82995783
24* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81737439
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.81334776
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76351226
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.76171511
28TCF7_22412390_ChIP-Seq_EML_Mouse1.75794576
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69233440
30CJUN_26792858_Chip-Seq_BT549_Human1.67182836
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.66056176
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63626194
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60782638
34* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60197068
35* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60197068
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.60192640
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59010367
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.57284743
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55593124
40SPI1_23127762_ChIP-Seq_K562_Human1.51859200
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.51688140
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51241685
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49690471
44LXR_22292898_ChIP-Seq_THP-1_Human1.46897934
45* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44590862
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42533007
47MYB_26560356_Chip-Seq_TH2_Human1.42398782
48VDR_24787735_ChIP-Seq_THP-1_Human1.42344860
49* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41980487
50* KDM2B_26808549_Chip-Seq_DND41_Human1.41157703
51* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39562423
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38080473
53* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36082255
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35396185
55* MAF_26560356_Chip-Seq_TH1_Human1.32660220
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.31743248
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31319360
58* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29812539
59TP53_16413492_ChIP-PET_HCT116_Human1.28896228
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28365906
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28153389
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28109447
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25746749
64* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25073333
65MYC_22102868_ChIP-Seq_BL_Human1.24703280
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23229190
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22727224
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21463924
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20129580
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19698544
71* UBF1/2_26484160_Chip-Seq_HMECs_Human1.19266413
72* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19161722
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18330546
74SOX2_20726797_ChIP-Seq_SW620_Human1.16995222
75BRD4_25478319_ChIP-Seq_HGPS_Human1.16813932
76* GATA1_19941826_ChIP-Seq_K562_Human1.16746017
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.16361145
78* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16324393
79* KDM2B_26808549_Chip-Seq_K562_Human1.15799521
80* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15504780
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.14515176
82PU_27001747_Chip-Seq_BMDM_Mouse1.11330279
83* VDR_24763502_ChIP-Seq_THP-1_Human1.10736514
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.10557036
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.10557036
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10193504
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09760795
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09306085
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07929380
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06265704
91* MYB_26560356_Chip-Seq_TH1_Human1.06036368
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05502651
93SCL_19346495_ChIP-Seq_HPC-7_Human1.05342711
94SPI1_23547873_ChIP-Seq_NB4_Human1.04472728
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03145804
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.02787125
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02761303
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02597164
99UTX_26944678_Chip-Seq_JUKART_Human1.02010686
100* ATF3_27146783_Chip-Seq_COLON_Human1.01353589
101* KLF5_25053715_ChIP-Seq_YYC3_Human1.01332649
102* AHR_22903824_ChIP-Seq_MCF-7_Human0.99556515
103* LXR_22158963_ChIP-Seq_LIVER_Mouse0.99230099
104RXR_22158963_ChIP-Seq_LIVER_Mouse0.99094253
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98878508
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98859673
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97844143
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96845953
109* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96431519
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96064018
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95636500
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95383476
113* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95139025
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.94852903
115* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94234233
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93922812
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93741415
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93647126
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92644187
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92557836
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92557836
122* TP53_18474530_ChIP-ChIP_U2OS_Human0.90900946
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89739170
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89403839
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88849601
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87231036
127* RUNX1_22412390_ChIP-Seq_EML_Mouse0.87034391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.29359587
2MP0003300_gastrointestinal_ulcer3.06752291
3MP0005275_abnormal_skin_tensile2.97933382
4MP0003303_peritoneal_inflammation2.97908239
5MP0004510_myositis2.95843345
6MP0003724_increased_susceptibility_to2.87691877
7MP0008004_abnormal_stomach_pH2.40260224
8MP0010352_gastrointestinal_tract_polyps2.38765757
9MP0003705_abnormal_hypodermis_morpholog2.34986744
10MP0003436_decreased_susceptibility_to2.33548470
11MP0005058_abnormal_lysosome_morphology2.27461972
12MP0005076_abnormal_cell_differentiation2.11385280
13MP0004947_skin_inflammation2.10959530
14MP0003566_abnormal_cell_adhesion2.08810824
15MP0009840_abnormal_foam_cell2.08621471
16MP0003191_abnormal_cellular_cholesterol2.07978882
17MP0009278_abnormal_bone_marrow2.05007826
18MP0003279_aneurysm2.03732829
19MP0000685_abnormal_immune_system1.96940848
20MP0001790_abnormal_immune_system1.91520111
21MP0005387_immune_system_phenotype1.91520111
22MP0002060_abnormal_skin_morphology1.83857861
23MP0001533_abnormal_skeleton_physiology1.82754960
24MP0003763_abnormal_thymus_physiology1.81043852
25MP0002405_respiratory_system_inflammati1.79374322
26MP0002877_abnormal_melanocyte_morpholog1.79190098
27MP0001851_eye_inflammation1.78576307
28MP0001958_emphysema1.77928917
29MP0010155_abnormal_intestine_physiology1.77668678
30MP0002166_altered_tumor_susceptibility1.74785860
31MP0005000_abnormal_immune_tolerance1.74037364
32MP0005503_abnormal_tendon_morphology1.73732239
33MP0005023_abnormal_wound_healing1.72857265
34MP0006054_spinal_hemorrhage1.72536863
35MP0003172_abnormal_lysosome_physiology1.70044603
36MP0005451_abnormal_body_composition1.68060582
37MP0002254_reproductive_system_inflammat1.65171607
38MP0003828_pulmonary_edema1.63216204
39MP0002933_joint_inflammation1.62638365
40MP0004808_abnormal_hematopoietic_stem1.61232562
41MP0010368_abnormal_lymphatic_system1.59630267
42MP0003091_abnormal_cell_migration1.59292260
43MP0003453_abnormal_keratinocyte_physiol1.55727923
44MP0003448_altered_tumor_morphology1.54497855
45MP0001853_heart_inflammation1.54322686
46MP0003045_fibrosis1.51168752
47* MP0002998_abnormal_bone_remodeling1.49438234
48MP0005390_skeleton_phenotype1.47774581
49MP0001800_abnormal_humoral_immune1.44806083
50MP0001873_stomach_inflammation1.43107377
51MP0001879_abnormal_lymphatic_vessel1.43018610
52MP0002006_tumorigenesis1.41642237
53MP0008961_abnormal_basal_metabolism1.39471292
54* MP0002419_abnormal_innate_immunity1.38602690
55* MP0002452_abnormal_antigen_presenting1.37911606
56MP0009785_altered_susceptibility_to1.36994175
57MP0008260_abnormal_autophagy1.36893031
58MP0002723_abnormal_immune_serum1.36829169
59MP0010234_abnormal_vibrissa_follicle1.36654831
60MP0002138_abnormal_hepatobiliary_system1.36652645
61MP0002009_preneoplasia1.36318517
62MP0002148_abnormal_hypersensitivity_rea1.32063068
63MP0009764_decreased_sensitivity_to1.31883170
64MP0004272_abnormal_basement_membrane1.31105982
65MP0001243_abnormal_dermal_layer1.29452629
66MP0004883_abnormal_blood_vessel1.28977727
67MP0003866_abnormal_defecation1.28323270
68MP0005508_abnormal_skeleton_morphology1.25723920
69* MP0002420_abnormal_adaptive_immunity1.21915108
70* MP0001819_abnormal_immune_cell1.21175217
71MP0002332_abnormal_exercise_endurance1.20875025
72MP0005409_darkened_coat_color1.20697878
73MP0000733_abnormal_muscle_development1.19325320
74MP0005464_abnormal_platelet_physiology1.16522216
75MP0005164_abnormal_response_to1.15784386
76MP0001216_abnormal_epidermal_layer1.15204672
77MP0000465_gastrointestinal_hemorrhage1.15141985
78MP0000604_amyloidosis1.14410167
79MP0005025_abnormal_response_to1.14328023
80MP0000767_abnormal_smooth_muscle1.13748880
81MP0005671_abnormal_response_to1.13590560
82MP0001845_abnormal_inflammatory_respons1.11235849
83MP0000343_altered_response_to1.11029225
84MP0001881_abnormal_mammary_gland1.10278118
85MP0001545_abnormal_hematopoietic_system1.10191526
86MP0005397_hematopoietic_system_phenotyp1.10191526
87MP0000858_altered_metastatic_potential1.09717934
88MP0008469_abnormal_protein_level1.08326006
89MP0005623_abnormal_meninges_morphology1.08238636
90MP0001835_abnormal_antigen_presentation1.08235762
91MP0001542_abnormal_bone_strength1.07052449
92MP0002796_impaired_skin_barrier1.06574303
93MP0000249_abnormal_blood_vessel1.04873854
94MP0009384_cardiac_valve_regurgitation1.02517733
95* MP0003795_abnormal_bone_structure0.98600418
96MP0003941_abnormal_skin_development0.97732519
97MP0003690_abnormal_glial_cell0.94802279
98MP0000627_abnormal_mammary_gland0.89306780
99MP0001191_abnormal_skin_condition0.88310069
100MP0002398_abnormal_bone_marrow0.86589880
101MP0001849_ear_inflammation0.86489739
102MP0003075_altered_response_to0.85914171
103MP0002295_abnormal_pulmonary_circulatio0.84663290
104MP0005166_decreased_susceptibility_to0.83930556
105* MP0000716_abnormal_immune_system0.83522353
106MP0000703_abnormal_thymus_morphology0.83379453
107MP0006082_CNS_inflammation0.81676163
108* MP0002896_abnormal_bone_mineralization0.81590212
109MP0003656_abnormal_erythrocyte_physiolo0.80734317
110MP0005257_abnormal_intraocular_pressure0.80485327
111MP0005666_abnormal_adipose_tissue0.79990908
112MP0005595_abnormal_vascular_smooth0.79615741
113MP0002277_abnormal_respiratory_mucosa0.78882408
114MP0004782_abnormal_surfactant_physiolog0.78108758
115MP0005165_increased_susceptibility_to0.76298388
116MP0002168_other_aberrant_phenotype0.72694360
117MP0002722_abnormal_immune_system0.72609098
118MP0009333_abnormal_splenocyte_physiolog0.72206867
119MP0009931_abnormal_skin_appearance0.71159829
120MP0005167_abnormal_blood-brain_barrier0.70224356
121* MP0002429_abnormal_blood_cell0.69001616
122MP0003329_amyloid_beta_deposits0.68935539
123MP0005310_abnormal_salivary_gland0.68282741

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)4.57544113
2Persistence of primary teeth (HP:0006335)4.39847706
3Premature rupture of membranes (HP:0001788)4.31318438
4Orchitis (HP:0100796)3.99166293
5Protrusio acetabuli (HP:0003179)3.97239845
6Retrobulbar optic neuritis (HP:0100654)3.73676871
7Optic neuritis (HP:0100653)3.73676871
8Aortic dissection (HP:0002647)3.70243318
9Abnormality of macrophages (HP:0004311)3.63916704
10Myositis (HP:0100614)3.61455505
11Aortic aneurysm (HP:0004942)3.61190959
12Atrophic scars (HP:0001075)3.41656894
13Eczematoid dermatitis (HP:0000976)3.39548298
14Cerebral aneurysm (HP:0004944)3.38837192
15Abnormality of liposaccharide metabolism (HP:0010968)3.37006302
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.37006302
17Abnormality of glycolipid metabolism (HP:0010969)3.37006302
18Amyloidosis (HP:0011034)3.17931835
19Recurrent bacterial skin infections (HP:0005406)3.11837624
20Shallow orbits (HP:0000586)3.11683015
21Peritonitis (HP:0002586)3.10419202
22Recurrent abscess formation (HP:0002722)2.96275439
23Dysostosis multiplex (HP:0000943)2.94679261
24Dilatation of the ascending aorta (HP:0005111)2.92938771
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.90295457
26Osteolytic defects of the hand bones (HP:0009699)2.90295457
27Mitral valve prolapse (HP:0001634)2.89589996
28Stomatitis (HP:0010280)2.88082731
29Broad metatarsal (HP:0001783)2.87265728
30Vascular tortuosity (HP:0004948)2.81793127
31Arterial tortuosity (HP:0005116)2.74922695
32Recurrent gram-negative bacterial infections (HP:0005420)2.74115417
33Keratoconjunctivitis sicca (HP:0001097)2.69738636
34Increased IgE level (HP:0003212)2.65961597
35Fragile skin (HP:0001030)2.63836448
36Increased cerebral lipofuscin (HP:0011813)2.62869061
37Systemic lupus erythematosus (HP:0002725)2.59727450
38Increased connective tissue (HP:0009025)2.52604351
39Myocardial infarction (HP:0001658)2.52035449
40Abnormality of the nasal septum (HP:0000419)2.46198729
41Loss of speech (HP:0002371)2.45003067
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43955841
43Abnormality of polysaccharide metabolism (HP:0011012)2.43955841
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43955841
45Urinary glycosaminoglycan excretion (HP:0003541)2.43403510
46Mucopolysacchariduria (HP:0008155)2.43403510
47Alopecia of scalp (HP:0002293)2.43335959
48Arterial thrombosis (HP:0004420)2.43314831
49Spondylolisthesis (HP:0003302)2.42337061
50Milia (HP:0001056)2.41845842
51Broad face (HP:0000283)2.40741142
52Keratoconjunctivitis (HP:0001096)2.40595301
53Pulmonary infiltrates (HP:0002113)2.33180790
54Ankle contracture (HP:0006466)2.29392227
55Thick nail (HP:0001805)2.28611667
56Genu recurvatum (HP:0002816)2.26439602
57Elevated erythrocyte sedimentation rate (HP:0003565)2.25095471
58Cervical subluxation (HP:0003308)2.24534171
59Syringomyelia (HP:0003396)2.23120258
60Spinal cord lesions (HP:0100561)2.23120258
61Asymmetric septal hypertrophy (HP:0001670)2.19416251
62Hematochezia (HP:0002573)2.17210419
63Distal lower limb amyotrophy (HP:0008944)2.14600145
64Aneurysm (HP:0002617)2.13738580
65Rectal prolapse (HP:0002035)2.13681731
66Right ventricular cardiomyopathy (HP:0011663)2.13094529
67Malnutrition (HP:0004395)2.10393304
68Thin bony cortex (HP:0002753)2.10090636
69Upper limb muscle weakness (HP:0003484)2.06451961
70Neurofibrillary tangles (HP:0002185)2.05765770
71Spontaneous hematomas (HP:0007420)2.04166405
72Short nail (HP:0001799)2.03384466
73Absent frontal sinuses (HP:0002688)2.02123448
74Recurrent skin infections (HP:0001581)2.00738451
75Vacuolated lymphocytes (HP:0001922)2.00470110
76Interstitial pulmonary disease (HP:0006530)2.00196236
77Abnormality of the pericardium (HP:0001697)1.99784146
78Premature loss of primary teeth (HP:0006323)1.99606619
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.98586896
80Wormian bones (HP:0002645)1.97593417
81Bladder diverticulum (HP:0000015)1.96715664
82Striae distensae (HP:0001065)1.95704100
83Vertebral compression fractures (HP:0002953)1.95378088
84Soft skin (HP:0000977)1.93474813
85Hemoptysis (HP:0002105)1.93330845
86Follicular hyperkeratosis (HP:0007502)1.92678732
87Disproportionate tall stature (HP:0001519)1.91993151
88Recurrent fungal infections (HP:0002841)1.91358208
89Spinal rigidity (HP:0003306)1.88537318
90Abnormality of the distal phalanges of the toes (HP:0010182)1.88016259
91Axonal loss (HP:0003447)1.85203490
92Gangrene (HP:0100758)1.85189640
93Abnormality of complement system (HP:0005339)1.84850790
94Episodic fever (HP:0001954)1.84099972
95Pustule (HP:0200039)1.83576555
96Mitral regurgitation (HP:0001653)1.80548905
97Lower limb amyotrophy (HP:0007210)1.79010838
98Polygenic inheritance (HP:0010982)1.78449620
99Urticaria (HP:0001025)1.77314304
100Increased serum ferritin (HP:0003281)1.75496605
101Camptodactyly of toe (HP:0001836)1.73213695
102Blue sclerae (HP:0000592)1.71953582
103Nuclear cataract (HP:0100018)1.71688467
104Vasculitis (HP:0002633)1.70991772
105Autoimmune thrombocytopenia (HP:0001973)1.70965702
106Hypergammaglobulinemia (HP:0010702)1.70559779
107Emphysema (HP:0002097)1.70100733
108Glomerulonephritis (HP:0000099)1.68547224
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68368568
110Obstructive sleep apnea (HP:0002870)1.68117766
111Segmental peripheral demyelination/remyelination (HP:0003481)1.66316346
112Subacute progressive viral hepatitis (HP:0006572)1.66192875
113Gingivitis (HP:0000230)1.65669649
114Mildly elevated creatine phosphokinase (HP:0008180)1.64871838
115Recurrent viral infections (HP:0004429)1.64605251
116Colitis (HP:0002583)1.64091788
117Cerebral inclusion bodies (HP:0100314)1.63526419
118Elbow flexion contracture (HP:0002987)1.62617990
119Distal lower limb muscle weakness (HP:0009053)1.62399990
120Dislocated radial head (HP:0003083)1.61689409
121Joint laxity (HP:0001388)1.61592324
122Prolonged bleeding time (HP:0003010)1.60742130
123Narrow palate (HP:0000189)1.60647570
124Abnormality of primary teeth (HP:0006481)1.60636937
125Mitral stenosis (HP:0001718)1.60404930
126Complement deficiency (HP:0004431)1.59783319
127Epistaxis (HP:0000421)1.59764637
128Gastrointestinal infarctions (HP:0005244)1.58637842
129Mediastinal lymphadenopathy (HP:0100721)1.58175337
130Tibial bowing (HP:0002982)1.57500901
131Pulmonary artery stenosis (HP:0004415)1.57233712
132Flat acetabular roof (HP:0003180)1.56984557
133Abnormality of the peritoneum (HP:0002585)1.56734541
134Cellulitis (HP:0100658)1.55757651
135Hyperextensible skin (HP:0000974)1.54393565
136Ulnar claw (HP:0001178)1.54254235
137Acrocyanosis (HP:0001063)1.53035706
138Increased CSF protein (HP:0002922)1.52923400
139Abnormal platelet volume (HP:0011876)1.51299825
140Femoral bowing (HP:0002980)1.51182208
141Increased mean platelet volume (HP:0011877)1.50917083
142Pulmonary embolism (HP:0002204)1.50891116
143Bruising susceptibility (HP:0000978)1.50844801
144Abnormality of the radial head (HP:0003995)1.50156787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.48076847
2EPHA33.16439951
3TXK3.07835200
4EPHB12.97054416
5MAP3K142.89496205
6MAP4K12.59916720
7TGFBR22.48661079
8RIPK12.36718697
9TAOK32.09563719
10BLK2.06773873
11RIPK42.02959559
12IRAK32.00655847
13ERN11.88030957
14TTN1.83819586
15FGFR41.83040631
16JAK11.80799980
17MAP3K31.75136241
18TBK11.74651702
19NLK1.72909054
20ITK1.72754066
21CHUK1.72632231
22TAOK21.71613482
23FGFR31.71442964
24DMPK1.69645627
25IKBKB1.67186642
26IRAK41.66650213
27JAK31.62778187
28STK101.61532943
29BMX1.51606977
30TRIB31.50682021
31IKBKE1.46906590
32MAP3K131.46171644
33CDK121.43520018
34EEF2K1.39393019
35CDC42BPA1.39283303
36PIM21.39133403
37PTK61.38360574
38MOS1.36068797
39MAP3K61.31833776
40FER1.31334817
41PIM11.29312517
42ZAP701.25263536
43RPS6KA41.24766355
44MAPK151.19388148
45ICK1.18732065
46TEC1.18176195
47TYK21.17063245
48HCK1.16920931
49PDGFRB1.16149748
50BMPR21.13243562
51MAP3K101.11931212
52TRPM71.11874809
53IRAK21.11099507
54GRK71.10650045
55LATS11.08151759
56MATK1.03719384
57MAP3K21.01337709
58MAP2K31.01018703
59PDGFRA1.00257220
60MST40.97855356
61FES0.97160588
62DDR20.97096873
63MARK20.96618195
64EPHB20.96422722
65FGR0.94494822
66GSK3A0.93750934
67PTK20.91522972
68LATS20.90098210
69CSK0.89868253
70CDK60.88035042
71STK240.87448026
72TAOK10.87328986
73MAPK120.86131505
74TSSK60.85978048
75NUAK10.85931850
76LRRK20.85189352
77AKT30.84554830
78PRKD20.84004365
79FRK0.83149562
80TIE10.81155538
81PAK20.79142244
82PDPK10.78030732
83MAP3K10.77997597
84HIPK20.77921028
85GRK60.77020282
86JAK20.76902646
87MST1R0.76097019
88RPS6KA50.75726342
89KSR20.74724741
90BTK0.73819732
91RPS6KA20.73498947
92RPS6KA10.73115058
93EPHA20.72786588
94MAP3K70.72672744
95CSF1R0.72497010
96SIK10.70637245
97SMG10.70634488
98TGFBR10.69494222
99RPS6KC10.69408748
100RPS6KL10.69408748
101KDR0.68059757
102PRKCH0.67888111
103SGK30.67488675
104LCK0.67397086
105FGFR10.67031007
106IRAK10.64061043
107SIK30.64043286
108STK30.63849658
109PKN20.62220080
110MAPKAPK20.61508089
111MELK0.60969444
112CDK90.60404261
113PDK10.59988603
114PAK40.59567708
115SYK0.59136576
116PTK2B0.55885899
117MTOR0.54387832
118MAP3K50.53693421
119STK380.53281750
120RPS6KA60.53272677
121PIK3CG0.53010670
122PDK20.52623202
123RET0.51606735
124CAMK1D0.50893106
125INSR0.50549611
126MARK30.50222075
127CAMK1G0.50184208
128ABL20.49415644
129ALK0.49387203
130MAPK40.49366856
131LYN0.46411176
132MAP3K110.43799372
133ABL10.43459068
134MAP2K20.43388078
135PIK3CA0.42151384
136MAPK70.40765211
137IGF1R0.37698497
138FGFR20.37142946
139KIT0.36838620
140PRKG20.36825535
141STK110.36771194
142NEK90.36360376

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67532191
2Other glycan degradation_Homo sapiens_hsa005112.31126430
3* Osteoclast differentiation_Homo sapiens_hsa043802.24328366
4Leishmaniasis_Homo sapiens_hsa051402.01001150
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.00596631
6TNF signaling pathway_Homo sapiens_hsa046681.96133622
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.91884249
8Toxoplasmosis_Homo sapiens_hsa051451.82573813
9Malaria_Homo sapiens_hsa051441.77407561
10T cell receptor signaling pathway_Homo sapiens_hsa046601.61962831
11ECM-receptor interaction_Homo sapiens_hsa045121.58822411
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.52660262
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.49845946
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.44906155
15Measles_Homo sapiens_hsa051621.42448301
16Chronic myeloid leukemia_Homo sapiens_hsa052201.41303438
17Focal adhesion_Homo sapiens_hsa045101.40241553
18Amoebiasis_Homo sapiens_hsa051461.38726671
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38504598
20Acute myeloid leukemia_Homo sapiens_hsa052211.36456706
21Lysosome_Homo sapiens_hsa041421.34925991
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.34338192
23Proteoglycans in cancer_Homo sapiens_hsa052051.31501568
24Prolactin signaling pathway_Homo sapiens_hsa049171.31424921
25Adherens junction_Homo sapiens_hsa045201.30824281
26Legionellosis_Homo sapiens_hsa051341.30711322
27Small cell lung cancer_Homo sapiens_hsa052221.28724771
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27445289
29Hepatitis B_Homo sapiens_hsa051611.26638823
30Salmonella infection_Homo sapiens_hsa051321.24479080
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23502554
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23036518
33B cell receptor signaling pathway_Homo sapiens_hsa046621.22522478
34Shigellosis_Homo sapiens_hsa051311.18894201
35Pertussis_Homo sapiens_hsa051331.15152354
36Apoptosis_Homo sapiens_hsa042101.15061036
37Viral myocarditis_Homo sapiens_hsa054161.14831620
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13679544
39Graft-versus-host disease_Homo sapiens_hsa053321.12583992
40Hematopoietic cell lineage_Homo sapiens_hsa046401.11593403
41Pancreatic cancer_Homo sapiens_hsa052121.09889085
42Circadian rhythm_Homo sapiens_hsa047101.07801530
43MicroRNAs in cancer_Homo sapiens_hsa052061.07128008
44Rheumatoid arthritis_Homo sapiens_hsa053231.06954888
45Tuberculosis_Homo sapiens_hsa051521.06776023
46Platelet activation_Homo sapiens_hsa046111.06197092
47Allograft rejection_Homo sapiens_hsa053301.05530892
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03831286
49Influenza A_Homo sapiens_hsa051641.02757206
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00026486
51Chemokine signaling pathway_Homo sapiens_hsa040620.99956344
52Prion diseases_Homo sapiens_hsa050200.96934241
53HTLV-I infection_Homo sapiens_hsa051660.95838621
54TGF-beta signaling pathway_Homo sapiens_hsa043500.95770294
55Primary immunodeficiency_Homo sapiens_hsa053400.94243099
56GnRH signaling pathway_Homo sapiens_hsa049120.93082798
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.93046743
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92932501
59Antigen processing and presentation_Homo sapiens_hsa046120.92732019
60MAPK signaling pathway_Homo sapiens_hsa040100.92313685
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.92073059
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91266195
63Staphylococcus aureus infection_Homo sapiens_hsa051500.90858880
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89879706
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89775762
66Phagosome_Homo sapiens_hsa041450.89754214
67VEGF signaling pathway_Homo sapiens_hsa043700.88625961
68Non-small cell lung cancer_Homo sapiens_hsa052230.88033710
69FoxO signaling pathway_Homo sapiens_hsa040680.88007776
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87949775
71Hepatitis C_Homo sapiens_hsa051600.86184293
72Bladder cancer_Homo sapiens_hsa052190.85840551
73Renal cell carcinoma_Homo sapiens_hsa052110.83386807
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.83243655
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82971724
76Prostate cancer_Homo sapiens_hsa052150.80408892
77Insulin resistance_Homo sapiens_hsa049310.80237466
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78465786
79Colorectal cancer_Homo sapiens_hsa052100.78313375
80HIF-1 signaling pathway_Homo sapiens_hsa040660.77004715
81Pathways in cancer_Homo sapiens_hsa052000.76845918
82Dilated cardiomyopathy_Homo sapiens_hsa054140.75951787
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75106827
84Type II diabetes mellitus_Homo sapiens_hsa049300.74436843
85Complement and coagulation cascades_Homo sapiens_hsa046100.73903902
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.73766822
87Rap1 signaling pathway_Homo sapiens_hsa040150.72582762
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72387828
89Autoimmune thyroid disease_Homo sapiens_hsa053200.72324619
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72113412
91African trypanosomiasis_Homo sapiens_hsa051430.70481075
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70374041
93Protein digestion and absorption_Homo sapiens_hsa049740.70136683
94mTOR signaling pathway_Homo sapiens_hsa041500.70040795
95Herpes simplex infection_Homo sapiens_hsa051680.68528217
96Notch signaling pathway_Homo sapiens_hsa043300.68012430
97Choline metabolism in cancer_Homo sapiens_hsa052310.65727741
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65441284
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65156392
100Endocytosis_Homo sapiens_hsa041440.63788380
101Estrogen signaling pathway_Homo sapiens_hsa049150.63145794
102Viral carcinogenesis_Homo sapiens_hsa052030.61896829
103Asthma_Homo sapiens_hsa053100.61072881
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60776305
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59773656
106Ovarian steroidogenesis_Homo sapiens_hsa049130.58924488
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57911887
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57402955
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57334188
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57333065
111Endometrial cancer_Homo sapiens_hsa052130.57003062
112Type I diabetes mellitus_Homo sapiens_hsa049400.56902989
113Hippo signaling pathway_Homo sapiens_hsa043900.56575634
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55265378
115Insulin signaling pathway_Homo sapiens_hsa049100.53578438
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53342075
117ErbB signaling pathway_Homo sapiens_hsa040120.52232900
118Glioma_Homo sapiens_hsa052140.52157843
119Sphingolipid metabolism_Homo sapiens_hsa006000.51283846
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.50724269

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