FOSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)5.14778754
2negative regulation of erythrocyte differentiation (GO:0045647)4.41525709
3negative regulation of interleukin-8 production (GO:0032717)3.99702745
4positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.96206237
5regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.96206237
6microglial cell activation (GO:0001774)3.74870348
7embryonic process involved in female pregnancy (GO:0060136)3.74679889
8hemidesmosome assembly (GO:0031581)3.65958991
9negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.64856147
10regulation of gamma-delta T cell differentiation (GO:0045586)3.60421325
11regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.60317126
12positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.60317126
13negative regulation of protein autophosphorylation (GO:0031953)3.57967388
14regulation of gamma-delta T cell activation (GO:0046643)3.54014627
15mannose metabolic process (GO:0006013)3.50650113
16regulation of cell proliferation involved in kidney development (GO:1901722)3.49363171
17cellular extravasation (GO:0045123)3.49169610
18positive regulation of gamma-delta T cell activation (GO:0046645)3.45310139
19desmosome organization (GO:0002934)3.45014176
20regulation of p38MAPK cascade (GO:1900744)3.39987005
21interleukin-1-mediated signaling pathway (GO:0070498)3.34421441
22cell proliferation involved in kidney development (GO:0072111)3.34112816
23negative thymic T cell selection (GO:0045060)3.33265034
24positive regulation of p38MAPK cascade (GO:1900745)3.30250806
25SMAD protein signal transduction (GO:0060395)3.29550355
26negative regulation of inclusion body assembly (GO:0090084)3.27125386
27negative regulation of interleukin-6 production (GO:0032715)3.16101447
28negative T cell selection (GO:0043383)3.15436145
29positive regulation of mRNA catabolic process (GO:0061014)3.14902793
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.12635160
31T cell selection (GO:0045058)3.10359864
32atrioventricular valve morphogenesis (GO:0003181)3.04913708
33positive regulation of extracellular matrix organization (GO:1903055)3.03055111
34positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.00112710
35branching involved in labyrinthine layer morphogenesis (GO:0060670)2.95902113
36negative regulation of gluconeogenesis (GO:0045721)2.91560549
37histone H3-K36 demethylation (GO:0070544)2.90185338
38regulation of germinal center formation (GO:0002634)2.89891232
39positive thymic T cell selection (GO:0045059)2.89637357
40histone H3-K4 trimethylation (GO:0080182)2.88282719
41regulation of heterotypic cell-cell adhesion (GO:0034114)2.86735793
42establishment of endothelial barrier (GO:0061028)2.86104899
43regulation of mRNA catabolic process (GO:0061013)2.84893682
44response to peptidoglycan (GO:0032494)2.84246951
45surfactant homeostasis (GO:0043129)2.82874158
46regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.80649095
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79810478
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.79810478
49regulation of translation, ncRNA-mediated (GO:0045974)2.79810478
50regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.78560810
51mRNA transcription (GO:0009299)2.77688787
52germinal center formation (GO:0002467)2.75669249
53RNA destabilization (GO:0050779)2.74460897
54regulation of monocyte differentiation (GO:0045655)2.73598776
55cellular response to antibiotic (GO:0071236)2.73420499
56endothelial cell chemotaxis (GO:0035767)2.71091280
57positive regulation of T cell differentiation in thymus (GO:0033089)2.70673980
58response to muramyl dipeptide (GO:0032495)2.70221171
59positive regulation of glomerulus development (GO:0090193)2.70164249
603-UTR-mediated mRNA stabilization (GO:0070935)2.66665525
61regulation of interleukin-8 biosynthetic process (GO:0045414)2.65856123
62negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65268211
63positive regulation of tolerance induction (GO:0002645)2.65231736
64regulation of regulatory T cell differentiation (GO:0045589)2.63356126
65mRNA transcription from RNA polymerase II promoter (GO:0042789)2.62860699
66regulation of somitogenesis (GO:0014807)2.62358466
67ovulation from ovarian follicle (GO:0001542)2.62353877
68response to fluid shear stress (GO:0034405)2.60390377
69negative regulation of granulocyte differentiation (GO:0030853)2.60223890
70cellular response to gonadotropin stimulus (GO:0071371)2.59582463
71cell-cell junction maintenance (GO:0045217)2.59337635
72monocyte differentiation (GO:0030224)2.58888588
73positive regulation of granulocyte differentiation (GO:0030854)2.58258126
74positive regulation of astrocyte differentiation (GO:0048711)2.57308023
75negative regulation of interleukin-2 production (GO:0032703)2.57105421
76regulation of chemokine secretion (GO:0090196)2.55869439
77negative regulation of fatty acid transport (GO:2000192)2.55097638
78radial glial cell differentiation (GO:0060019)2.53504268
79mesodermal cell differentiation (GO:0048333)2.52780433
80angiogenesis involved in wound healing (GO:0060055)2.52030405
81negative regulation of interleukin-1 beta production (GO:0032691)2.51344067
82histone H3 deacetylation (GO:0070932)2.49107304
83negative regulation of cytokine biosynthetic process (GO:0042036)2.48154536
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47439652
85response to laminar fluid shear stress (GO:0034616)2.47071796
86regulation of tolerance induction (GO:0002643)2.46845984
87activated T cell proliferation (GO:0050798)2.46234080
88skeletal muscle cell differentiation (GO:0035914)2.45027367
89platelet-derived growth factor receptor signaling pathway (GO:0048008)2.44579678
90negative regulation of T cell mediated immunity (GO:0002710)2.44223023
91endoderm formation (GO:0001706)2.43859041
92cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.41659139
93gland morphogenesis (GO:0022612)2.41640774
94negative regulation of smooth muscle cell proliferation (GO:0048662)2.41415635
95germ cell migration (GO:0008354)2.41338204
96mitotic cell cycle arrest (GO:0071850)2.38427602
97histone demethylation (GO:0016577)2.38051339
98leukocyte aggregation (GO:0070486)2.37710236
99alpha-beta T cell differentiation (GO:0046632)2.37219725
100megakaryocyte development (GO:0035855)2.37158076
101lung lobe morphogenesis (GO:0060463)2.37075013
102regulation of interleukin-12 biosynthetic process (GO:0045075)2.36894073
103lymph vessel development (GO:0001945)2.36506647
104negative regulation of T-helper cell differentiation (GO:0045623)2.36332642
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.36332642
106positive regulation of Rap GTPase activity (GO:0032854)2.36201325
107macrophage activation (GO:0042116)2.35899533
108regulation of glomerulus development (GO:0090192)2.35068763
109regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.34670784
110histone lysine demethylation (GO:0070076)2.34001480
111definitive hemopoiesis (GO:0060216)2.33723124
112positive regulation of alpha-beta T cell differentiation (GO:0046638)2.33150292
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.32855064
114B cell homeostasis (GO:0001782)2.32275138
115CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31877259
116T-helper cell differentiation (GO:0042093)2.31877259
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31347297
118* cellular response to calcium ion (GO:0071277)2.31154989
119CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.30581736
120thymic T cell selection (GO:0045061)2.29656484
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29544795
122growth hormone receptor signaling pathway (GO:0060396)2.29150131
123cell migration involved in sprouting angiogenesis (GO:0002042)2.27905482
124wound healing, spreading of cells (GO:0044319)2.26559404
125positive regulation of heat generation (GO:0031652)2.26471124
126cellular response to fluid shear stress (GO:0071498)2.26188715
127negative regulation of bone resorption (GO:0045779)2.25365451
128* response to progesterone (GO:0032570)2.24726060
129pathway-restricted SMAD protein phosphorylation (GO:0060389)2.23557633
130vascular endothelial growth factor signaling pathway (GO:0038084)2.23479862
131heart valve morphogenesis (GO:0003179)2.23154015
132regulation of fever generation (GO:0031620)2.20617716
133positive regulation by host of viral transcription (GO:0043923)2.20383095
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.20213177
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.19043091
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.18835530
137blood vessel maturation (GO:0001955)2.18812529
138wound healing, spreading of epidermal cells (GO:0035313)2.16276646
139entrainment of circadian clock by photoperiod (GO:0043153)2.16073119
140interferon-gamma secretion (GO:0072643)2.16011384
141regulation of water loss via skin (GO:0033561)2.15777887
142skin morphogenesis (GO:0043589)2.14570074
143positive T cell selection (GO:0043368)2.13994132
144fibroblast migration (GO:0010761)2.13673804
145chemical homeostasis within a tissue (GO:0048875)2.13349934
146negative regulation of bone remodeling (GO:0046851)2.13313048
147interleukin-6-mediated signaling pathway (GO:0070102)2.13295053
148positive regulation of osteoclast differentiation (GO:0045672)2.12960243
149positive regulation of osteoblast proliferation (GO:0033690)2.10784350
150positive regulation of mRNA 3-end processing (GO:0031442)2.10259994
151negative regulation of glycoprotein biosynthetic process (GO:0010561)2.09919677
152lateral sprouting from an epithelium (GO:0060601)2.08038230
153peptidyl-tyrosine autophosphorylation (GO:0038083)2.07475052
154antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.07471896
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.05044747
156regulation of cytokine production involved in inflammatory response (GO:1900015)2.04875972
157positive regulation of chemokine secretion (GO:0090197)2.04811792
158regulation of heat generation (GO:0031650)2.04413645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.83661024
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55183430
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.28350531
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13299729
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.82957077
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75159473
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73598534
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.69045369
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.61247893
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60995991
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59886200
12VDR_21846776_ChIP-Seq_THP-1_Human2.13981304
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10306987
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99704600
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95350449
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93263496
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92816938
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.92165896
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.91996112
20CLOCK_20551151_ChIP-Seq_293T_Human1.91170560
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.88892671
22MYC_22102868_ChIP-Seq_BL_Human1.84327604
23RUNX_20019798_ChIP-Seq_JUKART_Human1.82464486
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79575961
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79003041
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76425023
27MYB_26560356_Chip-Seq_TH2_Human1.75901606
28SCL_19346495_ChIP-Seq_HPC-7_Human1.69658970
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68950577
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68950577
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68950577
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68145521
33* MAF_26560356_Chip-Seq_TH1_Human1.64227612
34UTX_26944678_Chip-Seq_JUKART_Human1.62719279
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.61740592
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.58184519
37* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55669911
38MYB_26560356_Chip-Seq_TH1_Human1.55107592
39AR_21572438_ChIP-Seq_LNCaP_Human1.51235464
40* CJUN_26792858_Chip-Seq_BT549_Human1.50850129
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50304551
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.47720254
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45627013
44AHR_22903824_ChIP-Seq_MCF-7_Human1.40348110
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.39900572
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.39037046
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36080037
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32985635
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32887626
50* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30994468
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30800789
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30529685
53* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30262706
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29923802
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29261272
56* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29227600
57VDR_24787735_ChIP-Seq_THP-1_Human1.28767516
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28583425
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.27704942
60GATA1_22025678_ChIP-Seq_K562_Human1.26833051
61* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25457841
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24786571
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.24305464
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.24107160
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.22430895
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21270539
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21201731
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.19905009
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19840019
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19840019
71TP53_16413492_ChIP-PET_HCT116_Human1.19836489
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18130617
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.17823325
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17406514
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16110404
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15366070
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12228617
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10736239
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10126424
80MAF_26560356_Chip-Seq_TH2_Human1.09472408
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07762475
82DROSHA_22980978_ChIP-Seq_HELA_Human1.07647811
83TP53_18474530_ChIP-ChIP_U2OS_Human1.07428794
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07262008
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07143523
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07107881
87* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06765873
88* KDM2B_26808549_Chip-Seq_K562_Human1.05849343
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05257835
90* IRF8_27001747_Chip-Seq_BMDM_Mouse1.04861242
91SOX2_20726797_ChIP-Seq_SW620_Human1.04085966
92GATA3_27048872_Chip-Seq_THYMUS_Human1.03506075
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.01935611
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01095416
95* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00667807
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00505096
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00070160
98KLF5_25053715_ChIP-Seq_YYC3_Human0.98824390
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.98525776
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98410896
101SPI1_23127762_ChIP-Seq_K562_Human0.98216259
102RXR_22108803_ChIP-Seq_LS180_Human0.98043002
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97518414
104EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97518414
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97368677
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.96602600
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96525575
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96260222
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95790560
110* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95653590
111MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95346166
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95180583
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95019678
114* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94404756
115JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94307036
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.94216576
117GATA1_19941826_ChIP-Seq_K562_Human0.93500839
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93342507
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.93106354
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92877492
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92851060
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92472703
123* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90844845
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.90535600
125GATA2_19941826_ChIP-Seq_K562_Human0.90451352
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90168523
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.90127354
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.90069077
129* LXR_22292898_ChIP-Seq_THP-1_Human0.89315397
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.88715029
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88607635
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.88480096
133* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88034714
134* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88009634
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.87584658
136* KDM2B_26808549_Chip-Seq_DND41_Human0.86674010
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85930302
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84844855
139* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84306141
140* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83915548
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83860896
142VDR_24763502_ChIP-Seq_THP-1_Human0.83447866
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82277804
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80220918
145SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78369793
146* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77931471
147RACK7_27058665_Chip-Seq_MCF-7_Human0.77619483
148PU_27001747_Chip-Seq_BMDM_Mouse0.77553240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.21144855
2MP0002254_reproductive_system_inflammat3.66216626
3MP0001851_eye_inflammation3.13018240
4MP0003828_pulmonary_edema2.72736588
5MP0000383_abnormal_hair_follicle2.60689488
6MP0010368_abnormal_lymphatic_system2.51906287
7MP0002009_preneoplasia2.50523642
8MP0002138_abnormal_hepatobiliary_system2.35518541
9MP0002877_abnormal_melanocyte_morpholog2.30234292
10MP0009278_abnormal_bone_marrow2.25283384
11MP0003303_peritoneal_inflammation2.20157414
12MP0010678_abnormal_skin_adnexa2.14699096
13MP0003453_abnormal_keratinocyte_physiol1.95295524
14MP0002060_abnormal_skin_morphology1.93561462
15MP0004272_abnormal_basement_membrane1.90854422
16MP0003300_gastrointestinal_ulcer1.90087277
17MP0008961_abnormal_basal_metabolism1.84783158
18MP0001346_abnormal_lacrimal_gland1.79561003
19MP0004947_skin_inflammation1.77615181
20MP0008995_early_reproductive_senescence1.71943503
21MP0001879_abnormal_lymphatic_vessel1.71514555
22MP0003941_abnormal_skin_development1.70994513
23MP0002277_abnormal_respiratory_mucosa1.62234534
24* MP0001501_abnormal_sleep_pattern1.58749053
25MP0005076_abnormal_cell_differentiation1.57087404
26MP0001790_abnormal_immune_system1.56621025
27MP0005387_immune_system_phenotype1.56621025
28MP0005275_abnormal_skin_tensile1.54063026
29MP0003045_fibrosis1.53986749
30MP0005025_abnormal_response_to1.53884805
31MP0010234_abnormal_vibrissa_follicle1.51103511
32MP0003172_abnormal_lysosome_physiology1.45171654
33MP0000566_synostosis1.44852788
34MP0001533_abnormal_skeleton_physiology1.43296089
35MP0001853_heart_inflammation1.42945893
36MP0005257_abnormal_intraocular_pressure1.42121833
37MP0003566_abnormal_cell_adhesion1.42058258
38MP0002998_abnormal_bone_remodeling1.41964435
39MP0002933_joint_inflammation1.41064502
40MP0004510_myositis1.40154731
41MP0005508_abnormal_skeleton_morphology1.39155972
42MP0001216_abnormal_epidermal_layer1.39014734
43MP0002405_respiratory_system_inflammati1.34907161
44MP0002796_impaired_skin_barrier1.34548948
45MP0005390_skeleton_phenotype1.33154911
46MP0002098_abnormal_vibrissa_morphology1.32525344
47MP0002928_abnormal_bile_duct1.29529356
48MP0000703_abnormal_thymus_morphology1.28298407
49MP0004381_abnormal_hair_follicle1.28062089
50MP0000716_abnormal_immune_system1.27731990
51MP0006138_congestive_heart_failure1.26289118
52MP0002398_abnormal_bone_marrow1.26165448
53MP0004782_abnormal_surfactant_physiolog1.24801938
54MP0002166_altered_tumor_susceptibility1.24494852
55MP0005000_abnormal_immune_tolerance1.22213251
56MP0002896_abnormal_bone_mineralization1.21013453
57MP0000681_abnormal_thyroid_gland1.20880414
58MP0004883_abnormal_blood_vessel1.20568865
59MP0005023_abnormal_wound_healing1.19868305
60MP0005503_abnormal_tendon_morphology1.19506026
61MP0005166_decreased_susceptibility_to1.18215288
62MP0003943_abnormal_hepatobiliary_system1.17594118
63MP0005367_renal/urinary_system_phenotyp1.16751745
64MP0000516_abnormal_urinary_system1.16751745
65MP0000767_abnormal_smooth_muscle1.16739016
66MP0009840_abnormal_foam_cell1.16037526
67MP0002148_abnormal_hypersensitivity_rea1.15085494
68MP0000685_abnormal_immune_system1.14873019
69MP0000762_abnormal_tongue_morphology1.14459502
70MP0001542_abnormal_bone_strength1.13494289
71MP0004808_abnormal_hematopoietic_stem1.10529145
72MP0001873_stomach_inflammation1.09629415
73MP0001800_abnormal_humoral_immune1.09615147
74MP0002723_abnormal_immune_serum1.08600652
75MP0002722_abnormal_immune_system1.07893106
76MP0005058_abnormal_lysosome_morphology1.07585043
77MP0003448_altered_tumor_morphology1.07399568
78MP0009250_abnormal_appendicular_skeleto1.07097153
79MP0002419_abnormal_innate_immunity1.06477782
80MP0003279_aneurysm1.06422287
81MP0001958_emphysema1.06212589
82MP0008004_abnormal_stomach_pH1.06148565
83MP0000465_gastrointestinal_hemorrhage1.05850867
84MP0003656_abnormal_erythrocyte_physiolo1.05453494
85MP0002452_abnormal_antigen_presenting1.04292988
86MP0008438_abnormal_cutaneous_collagen1.04059631
87MP0001845_abnormal_inflammatory_respons1.02847128
88MP0003436_decreased_susceptibility_to1.02496732
89MP0003075_altered_response_to1.01176466
90MP0000689_abnormal_spleen_morphology0.99618342
91MP0003795_abnormal_bone_structure0.98221877
92MP0004264_abnormal_extraembryonic_tissu0.97835760
93MP0002006_tumorigenesis0.97522013
94MP0004043_abnormal_pH_regulation0.97511919
95MP0005164_abnormal_response_to0.96939686
96MP0003763_abnormal_thymus_physiology0.96837509
97MP0001191_abnormal_skin_condition0.95865422
98MP0002429_abnormal_blood_cell0.95576790
99MP0001502_abnormal_circadian_rhythm0.95474157
100MP0001340_abnormal_eyelid_morphology0.91604110
101MP0003091_abnormal_cell_migration0.91450856
102MP0000249_abnormal_blood_vessel0.91300653
103MP0002295_abnormal_pulmonary_circulatio0.91199547
104MP0010771_integument_phenotype0.88745922
105MP0004484_altered_response_of0.88506789
106MP0000467_abnormal_esophagus_morphology0.88452736
107MP0005388_respiratory_system_phenotype0.87673055
108MP0002133_abnormal_respiratory_system0.87673055
109MP0005666_abnormal_adipose_tissue0.87258447
110MP0002420_abnormal_adaptive_immunity0.87176068
111MP0005397_hematopoietic_system_phenotyp0.85802950
112MP0001545_abnormal_hematopoietic_system0.85802950
113MP0001819_abnormal_immune_cell0.85127061
114MP0005167_abnormal_blood-brain_barrier0.84679389
115MP0003866_abnormal_defecation0.82704017
116MP0001243_abnormal_dermal_layer0.82578439
117MP0009333_abnormal_splenocyte_physiolog0.81644025
118MP0009785_altered_susceptibility_to0.80867036
119MP0002396_abnormal_hematopoietic_system0.80803973
120MP0010155_abnormal_intestine_physiology0.79326436
121MP0005375_adipose_tissue_phenotype0.79172932
122MP0001835_abnormal_antigen_presentation0.78765773
123MP0000470_abnormal_stomach_morphology0.78172685
124MP0002925_abnormal_cardiovascular_devel0.77143291
125MP0009384_cardiac_valve_regurgitation0.74730630
126MP0001986_abnormal_taste_sensitivity0.74059128
127MP0005464_abnormal_platelet_physiology0.72460596
128MP0005670_abnormal_white_adipose0.71965570
129MP0008469_abnormal_protein_level0.70790690
130MP0005671_abnormal_response_to0.67609995
131MP0005310_abnormal_salivary_gland0.67489557
132MP0006082_CNS_inflammation0.64637490
133MP0001663_abnormal_digestive_system0.61733449

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)4.06620395
2Atrophic scars (HP:0001075)3.55696168
3Elevated erythrocyte sedimentation rate (HP:0003565)3.50146355
4Stomach cancer (HP:0012126)3.35898372
5Lip pit (HP:0100267)3.29438716
6Broad face (HP:0000283)3.21684533
7Cerebral aneurysm (HP:0004944)3.13978798
8Papilledema (HP:0001085)3.07789624
9Arterial tortuosity (HP:0005116)2.91771138
10Abnormal delayed hypersensitivity skin test (HP:0002963)2.81210986
11Abnormality of the nasal septum (HP:0000419)2.80096267
12Aplasia cutis congenita (HP:0001057)2.76511543
13Persistence of primary teeth (HP:0006335)2.75302668
14Aortic aneurysm (HP:0004942)2.75071639
15Stomatitis (HP:0010280)2.74075611
16Vascular tortuosity (HP:0004948)2.70520299
17Interstitial pulmonary disease (HP:0006530)2.69827801
18Autoimmune hemolytic anemia (HP:0001890)2.67118154
19Onycholysis (HP:0001806)2.65940804
20Pustule (HP:0200039)2.64646005
21Alveolar cell carcinoma (HP:0006519)2.63032590
22Panhypogammaglobulinemia (HP:0003139)2.60900315
23Hematochezia (HP:0002573)2.54845957
24Hypoplasia of dental enamel (HP:0006297)2.54172288
25Neoplasm of the tracheobronchial system (HP:0100552)2.50191450
26Recurrent bacterial skin infections (HP:0005406)2.46736440
27Recurrent fungal infections (HP:0002841)2.45523258
28Prostate neoplasm (HP:0100787)2.42987520
29Dysostosis multiplex (HP:0000943)2.40788245
30Aplasia involving bones of the extremities (HP:0009825)2.38373264
31Aplasia involving bones of the upper limbs (HP:0009823)2.38373264
32Aplasia of the phalanges of the hand (HP:0009802)2.38373264
33Broad metatarsal (HP:0001783)2.37687591
34Abnormality of male internal genitalia (HP:0000022)2.37354424
35Abnormality of the prostate (HP:0008775)2.33677351
36Recurrent abscess formation (HP:0002722)2.32325941
37Recurrent gram-negative bacterial infections (HP:0005420)2.31713431
38Growth hormone excess (HP:0000845)2.31029037
39Anhidrosis (HP:0000970)2.30270836
40Oligodontia (HP:0000677)2.27473352
41Amyloidosis (HP:0011034)2.26424682
42Abnormality of macrophages (HP:0004311)2.24711249
43Thick nail (HP:0001805)2.23981361
44Premature skin wrinkling (HP:0100678)2.23790169
45Aortic dissection (HP:0002647)2.23513661
46Nasolacrimal duct obstruction (HP:0000579)2.23313804
47Orchitis (HP:0100796)2.23271446
48Autoimmune thrombocytopenia (HP:0001973)2.22635906
49Pulmonary artery stenosis (HP:0004415)2.21424909
50Plantar hyperkeratosis (HP:0007556)2.19113171
51Thyroid-stimulating hormone excess (HP:0002925)2.18301075
52Optic neuritis (HP:0100653)2.17827362
53Retrobulbar optic neuritis (HP:0100654)2.17827362
54Ulnar claw (HP:0001178)2.17250026
55Genetic anticipation (HP:0003743)2.16520118
56Hypoplasia of the iris (HP:0007676)2.15478703
57Down-sloping shoulders (HP:0200021)2.12479003
58Shallow orbits (HP:0000586)2.10263056
59Polygenic inheritance (HP:0010982)2.10118791
60Alacrima (HP:0000522)2.08807687
61Abnormality of the distal phalanx of the thumb (HP:0009617)2.05756590
62Fragile nails (HP:0001808)2.04630316
63Myositis (HP:0100614)2.02741241
64Glucose intolerance (HP:0000833)2.02425927
65Recurrent viral infections (HP:0004429)2.00942929
66Abnormality of the fingertips (HP:0001211)2.00653956
67Upper limb muscle weakness (HP:0003484)1.99217294
68Urinary glycosaminoglycan excretion (HP:0003541)1.99200440
69Mucopolysacchariduria (HP:0008155)1.99200440
70Dislocated radial head (HP:0003083)1.98610337
71Colitis (HP:0002583)1.98039736
72Segmental peripheral demyelination/remyelination (HP:0003481)1.97908918
73Joint stiffness (HP:0001387)1.95636294
74Abnormality of the columella (HP:0009929)1.95108364
75Abnormality of polysaccharide metabolism (HP:0011012)1.95079060
76Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95079060
77Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95079060
78Bronchomalacia (HP:0002780)1.95004467
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.94392758
80Osteolytic defects of the hand bones (HP:0009699)1.94392758
81Disproportionate tall stature (HP:0001519)1.93480357
82Abnormality of the radial head (HP:0003995)1.93089620
83Rectal prolapse (HP:0002035)1.91872010
84Vasculitis (HP:0002633)1.91349544
85Xerostomia (HP:0000217)1.89512126
86Mixed hearing impairment (HP:0000410)1.89188642
87Mediastinal lymphadenopathy (HP:0100721)1.87925248
88Distal lower limb muscle weakness (HP:0009053)1.87629252
89Submucous cleft hard palate (HP:0000176)1.87531160
90Epistaxis (HP:0000421)1.86214432
91White forelock (HP:0002211)1.86046070
92Abnormality of the 2nd finger (HP:0004100)1.85939763
93Acanthosis nigricans (HP:0000956)1.85788154
94Parakeratosis (HP:0001036)1.85195853
95Mitral valve prolapse (HP:0001634)1.84896217
96Fragile skin (HP:0001030)1.84841238
97Conical tooth (HP:0000698)1.83755987
98Eczematoid dermatitis (HP:0000976)1.83498506
99Slow saccadic eye movements (HP:0000514)1.81393252
100Abnormality of the lacrimal duct (HP:0011481)1.81326728
101Hypotrichosis (HP:0001006)1.80996114
102Premature rupture of membranes (HP:0001788)1.80981926
103Meningitis (HP:0001287)1.80776750
104Myocardial infarction (HP:0001658)1.80661474
105Keratoconjunctivitis (HP:0001096)1.79934902
106Hypoplastic iliac wings (HP:0002866)1.79831328
107Recurrent skin infections (HP:0001581)1.79483759
108Seborrheic dermatitis (HP:0001051)1.77177074
109Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76565253
110Broad hallux (HP:0010055)1.75025481
111Abnormality of primary teeth (HP:0006481)1.74810702
112Hemoptysis (HP:0002105)1.73788028
113Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73648878
114Spontaneous hematomas (HP:0007420)1.73644465
115Abnormality of the nasolacrimal system (HP:0000614)1.72923237
116Midline defect of the nose (HP:0004122)1.72747839
117Neonatal hypoglycemia (HP:0001998)1.72218297
118Laryngomalacia (HP:0001601)1.72128695
119Decreased lacrimation (HP:0000633)1.71696201
120Restrictive lung disease (HP:0002091)1.71658396
121Aortic regurgitation (HP:0001659)1.71534337
122Tracheomalacia (HP:0002779)1.70757601
123Sleep apnea (HP:0010535)1.70586078
124Short clavicles (HP:0000894)1.70390345
125Urethral obstruction (HP:0000796)1.69730492
126Follicular hyperkeratosis (HP:0007502)1.69706971
127Premature loss of primary teeth (HP:0006323)1.69477854
128Epiphyseal dysplasia (HP:0002656)1.69455289
129Alopecia of scalp (HP:0002293)1.69348159
130Pulmonary hypertension (HP:0002092)1.69339119
131Type I diabetes mellitus (HP:0100651)1.69216385
132Inflammation of the large intestine (HP:0002037)1.68230492
133Chronic otitis media (HP:0000389)1.67906027
134Increased CSF protein (HP:0002922)1.66769574
135Advanced eruption of teeth (HP:0006288)1.65934077
136Skin pits (HP:0100276)1.64851642
137Abnormality of the parietal bone (HP:0002696)1.64744505
138Abnormality of T cell physiology (HP:0011840)1.64424937
139Granulocytopenia (HP:0001913)1.64111774
140Supernumerary ribs (HP:0005815)1.63886636
141Cheilitis (HP:0100825)1.63410251
142Acute myeloid leukemia (HP:0004808)1.63309550
143Tetraparesis (HP:0002273)1.62979743
144Onion bulb formation (HP:0003383)1.62948879
145Hypoplastic labia majora (HP:0000059)1.62717708
146Obstructive sleep apnea (HP:0002870)1.62644139
147Gastrointestinal inflammation (HP:0004386)1.62496985
148Accelerated skeletal maturation (HP:0005616)1.62243401
149Right ventricular cardiomyopathy (HP:0011663)1.61727094
150Increased density of long bones (HP:0006392)1.60444387
151Keratoconjunctivitis sicca (HP:0001097)1.59790346
152Patchy hypopigmentation of hair (HP:0011365)1.59329181
153Prolonged bleeding time (HP:0003010)1.58743166
154Abnormality of incisor morphology (HP:0011063)1.56944518
155Hip dysplasia (HP:0001385)1.56479425
156Spondylolisthesis (HP:0003302)1.56442670
157Increased IgE level (HP:0003212)1.53599953
158Abnormality of the gastric mucosa (HP:0004295)1.53417803
159Cupped ear (HP:0000378)1.53374716
160Bone pain (HP:0002653)1.53326614
161Narrow palate (HP:0000189)1.52506005
162Pulmonary infiltrates (HP:0002113)1.51834474
163Abnormality of the distal phalanges of the toes (HP:0010182)1.49914016
164Chronic mucocutaneous candidiasis (HP:0002728)1.49591631
165Recurrent cutaneous fungal infections (HP:0011370)1.49591631
166Anteriorly placed anus (HP:0001545)1.49451777
167Germ cell neoplasia (HP:0100728)1.49088635
168Trigonocephaly (HP:0000243)1.48997563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.24560929
2TGFBR23.59166193
3MAP2K22.92630463
4PRPF4B2.53186723
5TIE12.40977157
6EPHB12.27151929
7VRK12.08623762
8TRIB31.99221248
9MAP3K141.95710950
10MAPKAPK51.89965498
11EPHA31.86573380
12EPHA21.74860086
13TSSK61.73696385
14MAP3K31.68860189
15DMPK1.60990300
16ITK1.56600966
17IRAK31.49219065
18IKBKB1.47181304
19CDK31.45445821
20CHUK1.37099160
21RIPK11.36021851
22STK101.35103004
23INSRR1.34310426
24TAOK31.30830047
25MAP3K21.29813906
26TNK21.29715917
27MAP3K71.28458161
28FES1.26722940
29MST41.25194324
30HIPK21.21351636
31GRK71.20936859
32NLK1.18079511
33RIPK41.17459635
34GSK3A1.15796255
35MAP3K131.14095743
36GRK61.12995923
37JAK11.12868907
38FGFR21.11203030
39MAPK71.09226313
40FER1.08903628
41FGFR31.08727072
42CDK121.07457004
43FGFR41.06798544
44MAP3K11.03931372
45IRAK11.03193626
46TEC1.02121794
47PAK21.00700727
48TRPM71.00457522
49PDGFRB1.00294719
50IKBKE0.98205760
51BLK0.95426738
52MAP4K10.95247182
53CDC42BPA0.91499805
54BRD40.91442196
55MAPK120.90698568
56AKT30.90033390
57PRKD20.88309961
58TBK10.88239522
59TXK0.86132532
60SIK10.84339316
61MAPKAPK20.83851242
62TYK20.81587731
63CAMK1G0.79746252
64SIK30.79617105
65PTK60.77633255
66BMPR20.77318899
67LCK0.76490220
68RPS6KA50.74899323
69IRAK20.74761247
70RPS6KA20.73532740
71TGFBR10.72139037
72SYK0.71828263
73SGK20.66861721
74ZAP700.66805199
75JAK30.66022344
76CAMK1D0.65087041
77CAMK40.64799670
78PASK0.63390254
79EPHB20.60199709
80CSK0.59316397
81HCK0.58887559
82MAPK40.58433292
83LATS10.57895643
84CDK90.57534552
85NUAK10.56372619
86BTK0.56315407
87STK240.56082118
88MKNK20.55991794
89CLK10.55738614
90BMPR1B0.55714763
91TAOK10.55082577
92PTK2B0.54652364
93RPS6KA60.53873657
94SIK20.52959646
95PRKD10.52867506
96PDK10.51702083
97MAPKAPK30.51193066
98ERBB20.51005404
99SGK30.50622627
100CDK60.50205496
101JAK20.50062189
102IRAK40.49811639
103RPS6KL10.49536326
104RPS6KC10.49536326
105RPS6KA40.48413194
106MOS0.47604507
107KDR0.47238655
108MAPK30.46237479
109MAPK80.45953302
110ERN10.45857468
111TTN0.45838404
112MARK30.45144053
113EEF2K0.44725364
114PTK20.43663640
115ERBB30.43386710
116MAP3K60.42975685
117PIK3CG0.42947852
118MAP3K100.42828849
119MARK20.42596395
120IGF1R0.41809071
121MAPK10.40416552
122STK110.40276956
123MAP2K30.39555951
124KIT0.38394308
125MAP2K10.36864634
126MTOR0.36764386
127PRKAA20.34824302
128CSF1R0.34613810
129INSR0.33994861
130BMX0.33961675
131MATK0.33443023
132RPS6KB20.33310255
133RPS6KA10.33135447

Predicted pathways (KEGG)

RankGene SetZ-score
1* Osteoclast differentiation_Homo sapiens_hsa043802.15646677
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11544039
3ECM-receptor interaction_Homo sapiens_hsa045121.87721098
4TNF signaling pathway_Homo sapiens_hsa046681.82486708
5Leishmaniasis_Homo sapiens_hsa051401.80294792
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74658415
7Dorso-ventral axis formation_Homo sapiens_hsa043201.69790080
8B cell receptor signaling pathway_Homo sapiens_hsa046621.67209138
9Toxoplasmosis_Homo sapiens_hsa051451.60206174
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.55006133
11Circadian rhythm_Homo sapiens_hsa047101.50694197
12Notch signaling pathway_Homo sapiens_hsa043301.31626088
13Autoimmune thyroid disease_Homo sapiens_hsa053201.29552605
14Malaria_Homo sapiens_hsa051441.29439960
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28869204
16T cell receptor signaling pathway_Homo sapiens_hsa046601.28857699
17Small cell lung cancer_Homo sapiens_hsa052221.28353499
18Prolactin signaling pathway_Homo sapiens_hsa049171.25608779
19Antigen processing and presentation_Homo sapiens_hsa046121.23397739
20Estrogen signaling pathway_Homo sapiens_hsa049151.23309018
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23268927
22Rheumatoid arthritis_Homo sapiens_hsa053231.22881320
23Focal adhesion_Homo sapiens_hsa045101.22293625
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22215659
25Amoebiasis_Homo sapiens_hsa051461.21766752
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20261604
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.20075418
28Hematopoietic cell lineage_Homo sapiens_hsa046401.18404291
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.16541726
30Adherens junction_Homo sapiens_hsa045201.15663171
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14015012
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13227350
33Pertussis_Homo sapiens_hsa051331.13216181
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09842002
35MAPK signaling pathway_Homo sapiens_hsa040101.08234244
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05677340
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04498552
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04032589
39Apoptosis_Homo sapiens_hsa042101.03066839
40Graft-versus-host disease_Homo sapiens_hsa053321.02418444
41African trypanosomiasis_Homo sapiens_hsa051431.01820614
42Hepatitis B_Homo sapiens_hsa051610.99072286
43HTLV-I infection_Homo sapiens_hsa051660.99024091
44Protein digestion and absorption_Homo sapiens_hsa049740.97037410
45Influenza A_Homo sapiens_hsa051640.97034144
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96235920
47Prostate cancer_Homo sapiens_hsa052150.95516437
48Prion diseases_Homo sapiens_hsa050200.95431079
49Chronic myeloid leukemia_Homo sapiens_hsa052200.95060485
50Type II diabetes mellitus_Homo sapiens_hsa049300.94415264
51Measles_Homo sapiens_hsa051620.93424381
52Proteoglycans in cancer_Homo sapiens_hsa052050.93245676
53Colorectal cancer_Homo sapiens_hsa052100.93156669
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92711288
55Platelet activation_Homo sapiens_hsa046110.92599000
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90925294
57Pathways in cancer_Homo sapiens_hsa052000.90467816
58Acute myeloid leukemia_Homo sapiens_hsa052210.89218582
59TGF-beta signaling pathway_Homo sapiens_hsa043500.88952675
60Allograft rejection_Homo sapiens_hsa053300.88734035
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.88562487
62Basal cell carcinoma_Homo sapiens_hsa052170.87868015
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.87353041
64Asthma_Homo sapiens_hsa053100.87011759
65Chemokine signaling pathway_Homo sapiens_hsa040620.85319888
66Non-small cell lung cancer_Homo sapiens_hsa052230.85177857
67Renal cell carcinoma_Homo sapiens_hsa052110.84906570
68GnRH signaling pathway_Homo sapiens_hsa049120.81306967
69Sphingolipid metabolism_Homo sapiens_hsa006000.80980924
70Salmonella infection_Homo sapiens_hsa051320.80782601
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80447931
72Pancreatic cancer_Homo sapiens_hsa052120.79302383
73MicroRNAs in cancer_Homo sapiens_hsa052060.79008114
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78511991
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78391753
76Inositol phosphate metabolism_Homo sapiens_hsa005620.76930833
77Rap1 signaling pathway_Homo sapiens_hsa040150.76871340
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76753434
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.75829823
80Wnt signaling pathway_Homo sapiens_hsa043100.75730210
81Choline metabolism in cancer_Homo sapiens_hsa052310.75485086
82Renin secretion_Homo sapiens_hsa049240.75401823
83mTOR signaling pathway_Homo sapiens_hsa041500.74952017
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.74396485
85Insulin resistance_Homo sapiens_hsa049310.74042404
86Legionellosis_Homo sapiens_hsa051340.73109706
87Staphylococcus aureus infection_Homo sapiens_hsa051500.73103460
88Axon guidance_Homo sapiens_hsa043600.72741748
89Hepatitis C_Homo sapiens_hsa051600.71545434
90* Cocaine addiction_Homo sapiens_hsa050300.70356447
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70227352
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70141645
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.68747139
94Ras signaling pathway_Homo sapiens_hsa040140.68575089
95cAMP signaling pathway_Homo sapiens_hsa040240.68562423
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68476593
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68344056
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67948809
99Hedgehog signaling pathway_Homo sapiens_hsa043400.67916193
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.67696237
101Primary immunodeficiency_Homo sapiens_hsa053400.67640495
102Herpes simplex infection_Homo sapiens_hsa051680.66823927
103FoxO signaling pathway_Homo sapiens_hsa040680.66687398
104Type I diabetes mellitus_Homo sapiens_hsa049400.66387107
105ErbB signaling pathway_Homo sapiens_hsa040120.66014866
106Hippo signaling pathway_Homo sapiens_hsa043900.65702489
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64579203
108Ovarian steroidogenesis_Homo sapiens_hsa049130.64314189
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64246207
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64233582
111Salivary secretion_Homo sapiens_hsa049700.63845334
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.61260208
113VEGF signaling pathway_Homo sapiens_hsa043700.60806046
114* Amphetamine addiction_Homo sapiens_hsa050310.60212037
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60020091
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59865966
117Oxytocin signaling pathway_Homo sapiens_hsa049210.59121160
118Tuberculosis_Homo sapiens_hsa051520.58105700
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.57764047
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57588429
121Pancreatic secretion_Homo sapiens_hsa049720.56777723
122Thyroid hormone synthesis_Homo sapiens_hsa049180.56560188
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.56179700
124Other glycan degradation_Homo sapiens_hsa005110.55784474
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55303332
126Endocytosis_Homo sapiens_hsa041440.54053495
127Endometrial cancer_Homo sapiens_hsa052130.52408292

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