FNIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucokinase activity (GO:0033131)4.87426935
2regulation of hexokinase activity (GO:1903299)4.87426935
3neutrophil activation involved in immune response (GO:0002283)4.10542536
4inositol phosphate catabolic process (GO:0071545)4.07855576
5positive regulation of glycolytic process (GO:0045821)4.07055519
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92179178
7regulation of type B pancreatic cell apoptotic process (GO:2000674)3.91197942
8positive regulation of protein autophosphorylation (GO:0031954)3.89618666
9keratinocyte development (GO:0003334)3.84822889
10protein K11-linked deubiquitination (GO:0035871)3.84445502
11regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.81411572
12regulation of protein glycosylation (GO:0060049)3.68967804
13polyol catabolic process (GO:0046174)3.63916272
14ketone body metabolic process (GO:1902224)3.63612572
15signal peptide processing (GO:0006465)3.63260597
16cellular ketone body metabolic process (GO:0046950)3.59468800
17phosphorylated carbohydrate dephosphorylation (GO:0046838)3.55465509
18inositol phosphate dephosphorylation (GO:0046855)3.55465509
19synapsis (GO:0007129)3.50466554
20parental behavior (GO:0060746)3.45630614
21platelet dense granule organization (GO:0060155)3.43153269
22protein prenylation (GO:0018342)3.33595254
23prenylation (GO:0097354)3.33595254
24lactate metabolic process (GO:0006089)3.33274303
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33213803
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.33213803
27modulation by symbiont of host immune response (GO:0052553)3.33213803
28positive regulation by symbiont of host defense response (GO:0052509)3.33213803
29modulation by symbiont of host defense response (GO:0052031)3.33213803
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33213803
31response to pheromone (GO:0019236)3.29000415
32nitric oxide mediated signal transduction (GO:0007263)3.28251029
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27545362
34positive regulation of cellular amide metabolic process (GO:0034250)3.27512081
35cornea development in camera-type eye (GO:0061303)3.17894883
36macroautophagy (GO:0016236)3.16700606
37regulation of meiosis I (GO:0060631)3.14316661
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.14076963
39L-fucose catabolic process (GO:0042355)3.12287770
40fucose catabolic process (GO:0019317)3.12287770
41L-fucose metabolic process (GO:0042354)3.12287770
42negative regulation of lipid storage (GO:0010888)3.10870009
43negative regulation of complement activation (GO:0045916)3.10054394
44insulin secretion (GO:0030073)3.08477022
45response to lipoprotein particle (GO:0055094)3.04424163
46endocrine pancreas development (GO:0031018)3.03973181
47positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.00236332
48water-soluble vitamin biosynthetic process (GO:0042364)3.00207542
49protein localization to Golgi apparatus (GO:0034067)2.99167053
50macrophage activation involved in immune response (GO:0002281)2.89923771
51negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.89163184
52regulation of protein autophosphorylation (GO:0031952)2.88357604
53negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.85608164
54positive regulation of glycoprotein biosynthetic process (GO:0010560)2.85418909
55microglial cell activation (GO:0001774)2.84327267
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82645390
57neural tube formation (GO:0001841)2.80144674
58intra-Golgi vesicle-mediated transport (GO:0006891)2.78751503
59negative regulation of neurological system process (GO:0031645)2.78071204
60positive regulation of meiosis (GO:0045836)2.75427702
61negative regulation of protein activation cascade (GO:2000258)2.71780812
62phospholipid homeostasis (GO:0055091)2.68876077
63positive regulation of meiotic cell cycle (GO:0051446)2.68670646
64positive regulation of macroautophagy (GO:0016239)2.67083995
65negative regulation of neurotransmitter secretion (GO:0046929)2.66052709
66proline transport (GO:0015824)2.65667246
67zinc ion transport (GO:0006829)2.64432178
68regulation of glycolytic process (GO:0006110)2.62794627
69negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.61524347
70Golgi to endosome transport (GO:0006895)2.60437531
71negative regulation of acute inflammatory response (GO:0002674)2.59965436
72regulation of protein polyubiquitination (GO:1902914)2.59431638
73L-amino acid import (GO:0043092)2.58990155
74granulocyte activation (GO:0036230)2.58436670
75regulation of interferon-beta biosynthetic process (GO:0045357)2.57697896
76negative regulation of protein oligomerization (GO:0032460)2.57376029
77piRNA metabolic process (GO:0034587)2.56162204
78positive regulation of mitotic sister chromatid separation (GO:1901970)2.56037712
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56037712
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56037712
81production of molecular mediator involved in inflammatory response (GO:0002532)2.55422086
82neutrophil activation (GO:0042119)2.53502075
83indolalkylamine metabolic process (GO:0006586)2.51564456
84magnesium ion transport (GO:0015693)2.49615535
85ER overload response (GO:0006983)2.49116909
86macrophage activation (GO:0042116)2.47709768
87import into cell (GO:0098657)2.47388446
88regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.47146359
89UDP-N-acetylglucosamine metabolic process (GO:0006047)2.46013107
90regulation of Rac protein signal transduction (GO:0035020)2.45493226
91protein targeting to Golgi (GO:0000042)2.45289031
92inositol phosphate-mediated signaling (GO:0048016)2.44582747
93positive regulation of actin filament depolymerization (GO:0030836)2.44361827
94iron ion import (GO:0097286)2.43698073
95growth hormone receptor signaling pathway (GO:0060396)2.42908553
96xenobiotic catabolic process (GO:0042178)2.42867978
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42588404
98DNA deamination (GO:0045006)2.42470161
99indole-containing compound catabolic process (GO:0042436)2.42402818
100indolalkylamine catabolic process (GO:0046218)2.42402818
101tryptophan catabolic process (GO:0006569)2.42402818
102protein localization to cilium (GO:0061512)2.42147497
103negative regulation of protein autophosphorylation (GO:0031953)2.42140446
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40828765
105pancreas development (GO:0031016)2.40520336
106myeloid cell activation involved in immune response (GO:0002275)2.39859169
107respiratory burst (GO:0045730)2.39634248
108positive regulation of insulin secretion (GO:0032024)2.38775204
109I-kappaB phosphorylation (GO:0007252)2.38770554
110cellular response to ethanol (GO:0071361)2.37366111
111regulation of DNA endoreduplication (GO:0032875)2.35092766
112regulation of neurotransmitter uptake (GO:0051580)2.34405151
113cilium morphogenesis (GO:0060271)2.34330076
114endosome to pigment granule transport (GO:0043485)2.34115998
115endosome to melanosome transport (GO:0035646)2.34115998
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33842576
117negative regulation of mast cell activation (GO:0033004)2.33677917
118thyroid hormone metabolic process (GO:0042403)2.33586877
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.33542307
120brain morphogenesis (GO:0048854)2.33044424
121regulation of carbohydrate catabolic process (GO:0043470)2.32402303
122regulation of cellular carbohydrate catabolic process (GO:0043471)2.32402303
123fibroblast migration (GO:0010761)2.32042238
124kidney morphogenesis (GO:0060993)2.31311748
125anterograde synaptic vesicle transport (GO:0048490)2.31262688
126positive regulation of peptide hormone secretion (GO:0090277)2.31259024
127astrocyte differentiation (GO:0048708)2.31019912
128axoneme assembly (GO:0035082)2.30749400
129regulation of sequestering of triglyceride (GO:0010889)2.29607677
130cholesterol efflux (GO:0033344)2.29337761
131superoxide anion generation (GO:0042554)2.26264346
132regulation of lipoprotein metabolic process (GO:0050746)2.25581575
133regulation of macrophage derived foam cell differentiation (GO:0010743)2.24829166
134regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.24097772
135lipoprotein transport (GO:0042953)2.23247622
136establishment of protein localization to Golgi (GO:0072600)2.22274022
137glycosphingolipid catabolic process (GO:0046479)2.21784200
138retrograde transport, vesicle recycling within Golgi (GO:0000301)2.21383111
139positive regulation of p38MAPK cascade (GO:1900745)2.20162439
140early endosome to late endosome transport (GO:0045022)2.19844538
141protein localization to endosome (GO:0036010)2.19628818
142cytoplasmic mRNA processing body assembly (GO:0033962)2.18139646
143T-helper 1 type immune response (GO:0042088)2.17381653
144eosinophil chemotaxis (GO:0048245)2.17227886
145positive regulation of heat generation (GO:0031652)2.16480249
146tyrosine metabolic process (GO:0006570)2.15065970
147Rap protein signal transduction (GO:0032486)2.14598314
148neutrophil mediated immunity (GO:0002446)2.13262691
149positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.12184080
150response to host immune response (GO:0052572)2.11755732
151response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.11755732
152regulation of heat generation (GO:0031650)2.10264943
153regulation of activation of Janus kinase activity (GO:0010533)2.10072438
154sequestering of metal ion (GO:0051238)2.09790272
155protein carboxylation (GO:0018214)2.09318115
156peptidyl-glutamic acid carboxylation (GO:0017187)2.09318115
157developmental pigmentation (GO:0048066)2.09184863
158glycosylceramide metabolic process (GO:0006677)2.09120079
159prostate gland growth (GO:0060736)2.09042022
160cellular response to growth hormone stimulus (GO:0071378)2.06630459
161phagosome maturation (GO:0090382)2.06223445
162platelet-derived growth factor receptor signaling pathway (GO:0048008)2.06141622
163hydrogen peroxide biosynthetic process (GO:0050665)2.05986673
164intracellular pH reduction (GO:0051452)2.05964842
165regulation of mast cell activation involved in immune response (GO:0033006)2.05388357
166regulation of interleukin-8 biosynthetic process (GO:0045414)2.04535018
167negative regulation of neurotransmitter transport (GO:0051589)2.03992308
168amino acid import (GO:0043090)2.03680989
169low-density lipoprotein particle clearance (GO:0034383)2.03506449
170interleukin-1-mediated signaling pathway (GO:0070498)2.02958848
171regulation of mononuclear cell migration (GO:0071675)2.02517309
172regulation of mast cell degranulation (GO:0043304)2.01932077
173plasma lipoprotein particle clearance (GO:0034381)2.01148412
174regulation of energy homeostasis (GO:2000505)2.00118124
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.99686469
176positive regulation of muscle hypertrophy (GO:0014742)1.96151448
177positive regulation of cardiac muscle hypertrophy (GO:0010613)1.96151448
178regulation of cholesterol storage (GO:0010885)1.96058488
179nerve growth factor signaling pathway (GO:0038180)1.95233717
180regulation of beta-amyloid formation (GO:1902003)1.94404657
181glycolipid catabolic process (GO:0019377)1.94342884
182detection of molecule of bacterial origin (GO:0032490)1.93086796
183regulation of fever generation (GO:0031620)1.92957162
184regulation of mast cell activation (GO:0033003)1.92636513
185regulation of lipid storage (GO:0010883)1.92275721
186regulation of membrane protein ectodomain proteolysis (GO:0051043)1.92079457
187positive regulation of interferon-alpha production (GO:0032727)1.91113001
188regulation of cellular amide metabolic process (GO:0034248)1.90801967
189regulation of leukocyte degranulation (GO:0043300)1.88486553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.92907915
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52180037
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.49543953
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.49171767
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45857957
6ZNF274_21170338_ChIP-Seq_K562_Hela2.37241580
7GBX2_23144817_ChIP-Seq_PC3_Human2.34599953
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.33913637
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22039950
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.19623496
11VDR_22108803_ChIP-Seq_LS180_Human2.16073425
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15212054
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08327595
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.05613798
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.03834647
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90827917
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90564501
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.86478002
19NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79527557
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79527557
21EWS_26573619_Chip-Seq_HEK293_Human1.75610775
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71382970
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71245473
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62777484
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.62698589
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59247726
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56228368
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53527382
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51666815
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.51607783
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49903946
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48163584
33CBP_20019798_ChIP-Seq_JUKART_Human1.47555173
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47555173
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47443946
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47245799
37ER_23166858_ChIP-Seq_MCF-7_Human1.47137857
38VDR_24787735_ChIP-Seq_THP-1_Human1.46509105
39P300_19829295_ChIP-Seq_ESCs_Human1.45430076
40CDX2_22108803_ChIP-Seq_LS180_Human1.45290853
41TP53_16413492_ChIP-PET_HCT116_Human1.44713740
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.44297848
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41239072
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37048086
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36314521
46* CRX_20693478_ChIP-Seq_RETINA_Mouse1.36300843
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36104281
48SMAD4_21799915_ChIP-Seq_A2780_Human1.33735020
49* FLI1_21867929_ChIP-Seq_TH2_Mouse1.33508153
50STAT3_23295773_ChIP-Seq_U87_Human1.32779642
51* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32758769
52GATA1_22025678_ChIP-Seq_K562_Human1.31722945
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30416746
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29995889
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.29625171
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.29216184
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28795814
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.28435597
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27608536
60IGF1R_20145208_ChIP-Seq_DFB_Human1.26900412
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26594293
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.26389622
63ELK1_19687146_ChIP-ChIP_HELA_Human1.25111283
64CJUN_26792858_Chip-Seq_BT549_Human1.23988314
65TCF4_22108803_ChIP-Seq_LS180_Human1.23944803
66SOX2_19829295_ChIP-Seq_ESCs_Human1.21832311
67NANOG_19829295_ChIP-Seq_ESCs_Human1.21832311
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21556353
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21322286
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21007017
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20959398
72TP53_18474530_ChIP-ChIP_U2OS_Human1.20664341
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.20628849
74FUS_26573619_Chip-Seq_HEK293_Human1.19931064
75TAF15_26573619_Chip-Seq_HEK293_Human1.19895194
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17901106
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17709495
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17229368
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.16593203
80* TCF4_23295773_ChIP-Seq_U87_Human1.15976503
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15560694
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15300249
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14035506
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13469322
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12829802
86P53_22387025_ChIP-Seq_ESCs_Mouse1.12739332
87* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12610044
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11799723
89* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11762455
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08905990
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08267410
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.07959078
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07945869
94BRD4_25478319_ChIP-Seq_HGPS_Human1.07599433
95RUNX_20019798_ChIP-Seq_JUKART_Human1.07521832
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07309027
97TP53_22573176_ChIP-Seq_HFKS_Human1.07131412
98AR_25329375_ChIP-Seq_VCAP_Human1.06926638
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06849080
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06631585
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.06515594
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.06313854
103RXR_22158963_ChIP-Seq_LIVER_Mouse1.05557943
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.05372244
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.04931438
106HTT_18923047_ChIP-ChIP_STHdh_Human1.04605465
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04192457
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.04189018
109AHR_22903824_ChIP-Seq_MCF-7_Human1.03948673
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.03766575
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03272973
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.01998588
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01998526
114RXR_22108803_ChIP-Seq_LS180_Human1.01871206
115P300_18555785_Chip-Seq_ESCs_Mouse1.01670236
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.01383662
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01215204
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01134803
119* TP63_23658742_ChIP-Seq_EP156T_Human1.00993259
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.99473517
121TBL1_22424771_ChIP-Seq_293T_Human0.99097279
122FOXA2_19822575_ChIP-Seq_HepG2_Human0.98556590
123BCAT_22108803_ChIP-Seq_LS180_Human0.97506129
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97322756
125PU1_27457419_Chip-Seq_LIVER_Mouse0.96889952
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95923432
127* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95560355
128RUNX2_22187159_ChIP-Seq_PCA_Human0.95029604
129* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95002716
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.94585337
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94327270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.41672203
2MP0010234_abnormal_vibrissa_follicle3.64657762
3MP0005058_abnormal_lysosome_morphology3.14736982
4MP0002837_dystrophic_cardiac_calcinosis3.11472744
5MP0005171_absent_coat_pigmentation3.02965324
6MP0003787_abnormal_imprinting3.01825463
7MP0003690_abnormal_glial_cell2.86091150
8MP0003195_calcinosis2.81421728
9MP0008438_abnormal_cutaneous_collagen2.56605704
10MP0003183_abnormal_peptide_metabolism2.56595409
11MP0008877_abnormal_DNA_methylation2.52489358
12MP0002102_abnormal_ear_morphology2.46789403
13MP0002139_abnormal_hepatobiliary_system2.39196950
14MP0003172_abnormal_lysosome_physiology2.38161005
15MP0003252_abnormal_bile_duct2.37094499
16MP0010678_abnormal_skin_adnexa2.34270193
17MP0008057_abnormal_DNA_replication2.31591053
18MP0002877_abnormal_melanocyte_morpholog2.28058980
19MP0002638_abnormal_pupillary_reflex2.26269850
20MP0005379_endocrine/exocrine_gland_phen2.21310361
21MP0000920_abnormal_myelination2.17099678
22MP0000427_abnormal_hair_cycle2.14401943
23MP0006054_spinal_hemorrhage2.13147139
24MP0002419_abnormal_innate_immunity2.05314993
25MP0003283_abnormal_digestive_organ2.00471933
26MP0003436_decreased_susceptibility_to1.94646876
27MP0002876_abnormal_thyroid_physiology1.94489009
28MP0006082_CNS_inflammation1.83548980
29MP0003303_peritoneal_inflammation1.81663889
30MP0005220_abnormal_exocrine_pancreas1.79296423
31MP0002163_abnormal_gland_morphology1.77438091
32MP0005075_abnormal_melanosome_morpholog1.76320820
33MP0001944_abnormal_pancreas_morphology1.73835872
34MP0005646_abnormal_pituitary_gland1.70129949
35MP0000015_abnormal_ear_pigmentation1.69702242
36MP0001835_abnormal_antigen_presentation1.69628394
37MP0005645_abnormal_hypothalamus_physiol1.69125462
38MP0004510_myositis1.68171991
39MP0000383_abnormal_hair_follicle1.68123540
40MP0000013_abnormal_adipose_tissue1.64123477
41MP0004130_abnormal_muscle_cell1.63190616
42MP0002938_white_spotting1.59795553
43MP0003300_gastrointestinal_ulcer1.57974218
44MP0005464_abnormal_platelet_physiology1.57378040
45MP0002138_abnormal_hepatobiliary_system1.55839135
46MP0009046_muscle_twitch1.55020097
47MP0005257_abnormal_intraocular_pressure1.54961366
48MP0002998_abnormal_bone_remodeling1.54234558
49MP0000604_amyloidosis1.52961894
50MP0005551_abnormal_eye_electrophysiolog1.52409296
51MP0000516_abnormal_urinary_system1.50703622
52MP0005367_renal/urinary_system_phenotyp1.50703622
53MP0006072_abnormal_retinal_apoptosis1.48511773
54MP0002909_abnormal_adrenal_gland1.46650481
55MP0002254_reproductive_system_inflammat1.44535237
56MP0005253_abnormal_eye_physiology1.44300094
57MP0005085_abnormal_gallbladder_physiolo1.43449852
58MP0009840_abnormal_foam_cell1.43350823
59MP0003724_increased_susceptibility_to1.42067529
60MP0009697_abnormal_copulation1.39707031
61MP0005365_abnormal_bile_salt1.38033436
62MP0001533_abnormal_skeleton_physiology1.38018286
63MP0005000_abnormal_immune_tolerance1.37594781
64MP0004185_abnormal_adipocyte_glucose1.35516108
65MP0003075_altered_response_to1.35324386
66MP0003191_abnormal_cellular_cholesterol1.34883337
67MP0005408_hypopigmentation1.31222436
68MP0005167_abnormal_blood-brain_barrier1.30824901
69MP0009780_abnormal_chondrocyte_physiolo1.30313595
70MP0002148_abnormal_hypersensitivity_rea1.29829530
71MP0000371_diluted_coat_color1.26839652
72MP0005174_abnormal_tail_pigmentation1.26530559
73MP0003950_abnormal_plasma_membrane1.24746528
74MP0002095_abnormal_skin_pigmentation1.24632305
75MP0004043_abnormal_pH_regulation1.20272623
76MP0010352_gastrointestinal_tract_polyps1.17705481
77MP0002160_abnormal_reproductive_system1.15210063
78MP0005084_abnormal_gallbladder_morpholo1.15076600
79MP0003633_abnormal_nervous_system1.14272280
80MP0001324_abnormal_eye_pigmentation1.13685490
81MP0004381_abnormal_hair_follicle1.13600603
82MP0003656_abnormal_erythrocyte_physiolo1.13391226
83MP0000372_irregular_coat_pigmentation1.13282109
84MP0005389_reproductive_system_phenotype1.13135798
85MP0001851_eye_inflammation1.12912199
86MP0003646_muscle_fatigue1.12557121
87MP0001756_abnormal_urination1.11639289
88MP0002009_preneoplasia1.11541335
89MP0001661_extended_life_span1.08585159
90MP0002118_abnormal_lipid_homeostasis1.08314114
91MP0004484_altered_response_of1.06839195
92MP0002452_abnormal_antigen_presenting1.06582140
93MP0009764_decreased_sensitivity_to1.06195733
94MP0001984_abnormal_olfaction1.05936253
95MP0010329_abnormal_lipoprotein_level1.04406271
96MP0001501_abnormal_sleep_pattern1.03674485
97MP0003045_fibrosis1.01959588
98MP0005164_abnormal_response_to1.01723653
99MP0000613_abnormal_salivary_gland1.01545075
100MP0002928_abnormal_bile_duct1.00992633
101MP0003828_pulmonary_edema1.00981922
102MP0001986_abnormal_taste_sensitivity1.00528686
103MP0002295_abnormal_pulmonary_circulatio0.99877423
104MP0001790_abnormal_immune_system0.98948454
105MP0005387_immune_system_phenotype0.98948454
106MP0003634_abnormal_glial_cell0.98922257
107MP0002971_abnormal_brown_adipose0.98863104
108MP0003121_genomic_imprinting0.98469584
109MP0002933_joint_inflammation0.98450675
110MP0005332_abnormal_amino_acid0.98240980
111MP0002723_abnormal_immune_serum0.95978777
112MP0000647_abnormal_sebaceous_gland0.95341269
113MP0002090_abnormal_vision0.94951069
114MP0005334_abnormal_fat_pad0.94412738
115MP0005666_abnormal_adipose_tissue0.93272982
116MP0009785_altered_susceptibility_to0.93230257
117MP0005360_urolithiasis0.93185639
118MP0005310_abnormal_salivary_gland0.92820095
119MP0005025_abnormal_response_to0.91901481
120MP0003868_abnormal_feces_composition0.91165166
121MP0008775_abnormal_heart_ventricle0.91117099
122MP0003011_delayed_dark_adaptation0.90346788
123MP0000343_altered_response_to0.89096042
124MP0002006_tumorigenesis0.88392629
125MP0008469_abnormal_protein_level0.88346675
126MP0010386_abnormal_urinary_bladder0.87295774
127MP0005535_abnormal_body_temperature0.86495530
128MP0004134_abnormal_chest_morphology0.86223550
129MP0002693_abnormal_pancreas_physiology0.84252727
130MP0003091_abnormal_cell_migration0.83990206
131MP0000609_abnormal_liver_physiology0.83986934
132MP0003631_nervous_system_phenotype0.83781668
133MP0004215_abnormal_myocardial_fiber0.82914140
134MP0005375_adipose_tissue_phenotype0.82688246
135MP0003448_altered_tumor_morphology0.80907555
136MP0004742_abnormal_vestibular_system0.80300009
137MP0005187_abnormal_penis_morphology0.79856010
138MP0004924_abnormal_behavior0.78682714
139MP0005386_behavior/neurological_phenoty0.78682714
140MP0001845_abnormal_inflammatory_respons0.78230764
141MP0002133_abnormal_respiratory_system0.77294321
142MP0005388_respiratory_system_phenotype0.77294321
143MP0000538_abnormal_urinary_bladder0.76770155
144MP0005410_abnormal_fertilization0.76639851
145MP0005166_decreased_susceptibility_to0.76235409
146MP0004885_abnormal_endolymph0.75926741
147MP0005670_abnormal_white_adipose0.75722097
148MP0009763_increased_sensitivity_to0.75592479
149MP0002168_other_aberrant_phenotype0.75551212
150MP0008872_abnormal_physiological_respon0.75014329
151MP0003632_abnormal_nervous_system0.74940087
152MP0002078_abnormal_glucose_homeostasis0.74521376
153MP0002166_altered_tumor_susceptibility0.74428644
154MP0001177_atelectasis0.74089541
155MP0001299_abnormal_eye_distance/0.74027619
156MP0000631_abnormal_neuroendocrine_gland0.73642945
157MP0006292_abnormal_olfactory_placode0.73420197
158MP0002332_abnormal_exercise_endurance0.72762862
159MP0003136_yellow_coat_color0.72615808
160MP0006036_abnormal_mitochondrial_physio0.69886794
161MP0000639_abnormal_adrenal_gland0.69631136
162MP0003943_abnormal_hepatobiliary_system0.68647867
163MP0001919_abnormal_reproductive_system0.68477424
164MP0005248_abnormal_Harderian_gland0.66332437
165MP0005636_abnormal_mineral_homeostasis0.64965894
166MP0002075_abnormal_coat/hair_pigmentati0.64225073
167MP0003953_abnormal_hormone_level0.64199639
168MP0003786_premature_aging0.64069616
169MP0008875_abnormal_xenobiotic_pharmacok0.63973304

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)4.33847914
2Hypothermia (HP:0002045)4.29557209
3Hypoplasia of the fovea (HP:0007750)3.86803190
4Aplasia/Hypoplasia of the fovea (HP:0008060)3.86803190
5Hyperinsulinemic hypoglycemia (HP:0000825)3.68862788
6Recurrent gram-negative bacterial infections (HP:0005420)3.68474008
7Recurrent bacterial skin infections (HP:0005406)3.66084355
8Hypoglycemic seizures (HP:0002173)3.51533630
9Myocardial infarction (HP:0001658)3.47759058
10Hypoglycemic coma (HP:0001325)3.45014625
11Increased cerebral lipofuscin (HP:0011813)3.42112122
12Large for gestational age (HP:0001520)3.39450325
13Recurrent abscess formation (HP:0002722)3.38215839
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.34226012
15Eczematoid dermatitis (HP:0000976)3.33025292
16Neoplasm of the adrenal cortex (HP:0100641)3.32078907
17Abnormality of the fovea (HP:0000493)3.21911356
18Hamartoma of the eye (HP:0010568)3.15512930
19Albinism (HP:0001022)3.15248294
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.08226281
21Thyroiditis (HP:0100646)3.04902825
22Joint hemorrhage (HP:0005261)3.04394783
23Pancreatic cysts (HP:0001737)3.02573871
24Abnormality of macrophages (HP:0004311)3.00620555
25Axonal loss (HP:0003447)2.99951476
26Vacuolated lymphocytes (HP:0001922)2.99654500
27Hyperlipoproteinemia (HP:0010980)2.92521156
28Fair hair (HP:0002286)2.88172172
29Aplasia/Hypoplasia of the macula (HP:0008059)2.82718869
30Abnormality of the pancreatic islet cells (HP:0006476)2.82601109
31Abnormality of endocrine pancreas physiology (HP:0012093)2.82601109
32Submucous cleft hard palate (HP:0000176)2.80575511
33Abnormality of the renal cortex (HP:0011035)2.76834438
34Ketosis (HP:0001946)2.76223639
35Generalized hypopigmentation of hair (HP:0011358)2.71161343
36Hemiparesis (HP:0001269)2.69771390
37Gaze-evoked nystagmus (HP:0000640)2.68027219
38Absent frontal sinuses (HP:0002688)2.67299440
39Intestinal atresia (HP:0011100)2.66528980
40Methylmalonic acidemia (HP:0002912)2.66357699
41Systemic lupus erythematosus (HP:0002725)2.66205951
42Hyperventilation (HP:0002883)2.63625954
43Tongue fasciculations (HP:0001308)2.62611512
44Pancreatic fibrosis (HP:0100732)2.60268835
45Hypoplastic ischia (HP:0003175)2.59546253
46Aplasia/Hypoplasia affecting the retina (HP:0008061)2.58835436
47Conjunctival hamartoma (HP:0100780)2.58048536
48Hypoalphalipoproteinemia (HP:0003233)2.58011018
49Thick nail (HP:0001805)2.57427135
50Gingivitis (HP:0000230)2.53177238
51Abnormality of vitamin B metabolism (HP:0004340)2.45803111
52Dysostosis multiplex (HP:0000943)2.45795808
53Abnormal drinking behavior (HP:0030082)2.45750282
54Polydipsia (HP:0001959)2.45750282
55Aqueductal stenosis (HP:0002410)2.45642427
56Gingival bleeding (HP:0000225)2.44654563
57Congenital stationary night blindness (HP:0007642)2.43884877
58Abnormality of liposaccharide metabolism (HP:0010968)2.43784673
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.43784673
60Abnormality of glycolipid metabolism (HP:0010969)2.43784673
61Pancreatic islet-cell hyperplasia (HP:0004510)2.42244417
62Muscle fibrillation (HP:0010546)2.35880875
63Epiphyseal dysplasia (HP:0002656)2.34412860
64Protuberant abdomen (HP:0001538)2.33176476
65Enlarged penis (HP:0000040)2.32790911
66Abnormality of the ischium (HP:0003174)2.30164984
67Skin nodule (HP:0200036)2.30119757
68Blue irides (HP:0000635)2.28431382
69Hypomagnesemia (HP:0002917)2.28196809
70Neurofibrillary tangles (HP:0002185)2.27410463
71Mucopolysacchariduria (HP:0008155)2.27310987
72Urinary glycosaminoglycan excretion (HP:0003541)2.27310987
73Abnormal hair whorl (HP:0010721)2.26885067
74Xanthomatosis (HP:0000991)2.26472365
75Symptomatic seizures (HP:0011145)2.26331709
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25960887
77Nephronophthisis (HP:0000090)2.25940759
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25255252
79Disinhibition (HP:0000734)2.24812031
80Prolonged partial thromboplastin time (HP:0003645)2.24593704
81Metaphyseal dysplasia (HP:0100255)2.23283829
82Intrahepatic cholestasis (HP:0001406)2.22244627
83Renal cortical cysts (HP:0000803)2.21921689
84Furrowed tongue (HP:0000221)2.20542012
85Febrile seizures (HP:0002373)2.18699534
86Abnormality of the renal medulla (HP:0100957)2.18375833
87Abnormality of the common coagulation pathway (HP:0010990)2.18078484
88Cutaneous melanoma (HP:0012056)2.17850161
89True hermaphroditism (HP:0010459)2.17597276
90Abnormality of polysaccharide metabolism (HP:0011012)2.15799616
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15799616
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15799616
93Progressive macrocephaly (HP:0004481)2.14271465
94Abnormality of the intrinsic pathway (HP:0010989)2.14265747
95Abnormal rod and cone electroretinograms (HP:0008323)2.13459310
96Abnormality of midbrain morphology (HP:0002418)2.13340733
97Molar tooth sign on MRI (HP:0002419)2.13340733
98Abnormality of the frontal sinuses (HP:0002687)2.13044539
99Medial flaring of the eyebrow (HP:0010747)2.11377805
100Peripheral demyelination (HP:0011096)2.11323424
101Stomatitis (HP:0010280)2.07366532
102Upper motor neuron abnormality (HP:0002127)2.05706939
103Complement deficiency (HP:0004431)2.03229725
104Thyroid carcinoma (HP:0002890)2.02447779
105Conjugated hyperbilirubinemia (HP:0002908)2.02334115
106EEG with generalized epileptiform discharges (HP:0011198)2.01473403
107Tubulointerstitial nephritis (HP:0001970)2.00723216
108Recurrent skin infections (HP:0001581)2.00562758
109Epidermoid cyst (HP:0200040)2.00116174
110Breast carcinoma (HP:0003002)1.98013498
111Hypercholesterolemia (HP:0003124)1.97273419
112Tubular atrophy (HP:0000092)1.96673111
113Bell-shaped thorax (HP:0001591)1.96492690
114Hematochezia (HP:0002573)1.96292787
115Epileptiform EEG discharges (HP:0011182)1.95984834
116White forelock (HP:0002211)1.95093873
117Hypsarrhythmia (HP:0002521)1.94583305
118Retinal atrophy (HP:0001105)1.94008877
119Cone-rod dystrophy (HP:0000548)1.93811903
120Glomerulonephritis (HP:0000099)1.92805573
121Abnormal biliary tract morphology (HP:0012440)1.92162028
122Abnormality of the nasal septum (HP:0000419)1.91414146
123Patchy hypopigmentation of hair (HP:0011365)1.91273929
124Type II lissencephaly (HP:0007260)1.91267077
125Prostate neoplasm (HP:0100787)1.90593558
126Macroorchidism (HP:0000053)1.90471628
127Hyperkalemia (HP:0002153)1.90284816
128Generalized hypopigmentation (HP:0007513)1.90059913
129Progressive inability to walk (HP:0002505)1.89754351
130Abnormal pancreas size (HP:0012094)1.88065501
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.86400729
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86400729
133Disproportionate short-trunk short stature (HP:0003521)1.85604624
134Progressive visual loss (HP:0000529)1.85201402
135Attenuation of retinal blood vessels (HP:0007843)1.84426588
136Neoplasm of the adrenal gland (HP:0100631)1.84412770
137Abnormality of incisor morphology (HP:0011063)1.84263075
138Methylmalonic aciduria (HP:0012120)1.84093640
139Periodontitis (HP:0000704)1.84074339
140Mitral stenosis (HP:0001718)1.82703485
141Congenital sensorineural hearing impairment (HP:0008527)1.80461199
142Bilateral sensorineural hearing impairment (HP:0008619)1.80445950
143Optic neuritis (HP:0100653)1.80375418
144Retrobulbar optic neuritis (HP:0100654)1.80375418
145Excessive salivation (HP:0003781)1.80146411
146Drooling (HP:0002307)1.80146411
147Vascular calcification (HP:0004934)1.79676374
148Neoplasm of the tracheobronchial system (HP:0100552)1.79659141
149Downturned corners of mouth (HP:0002714)1.78258403
150Cervical subluxation (HP:0003308)1.78232044
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.77698450
152Cardiovascular calcification (HP:0011915)1.77573496
153Coarse hair (HP:0002208)1.76779631
154Increased CSF protein (HP:0002922)1.75459427
155Biliary tract neoplasm (HP:0100574)1.75305283
156Delayed gross motor development (HP:0002194)1.74633919
157Volvulus (HP:0002580)1.73942840
158Ovoid vertebral bodies (HP:0003300)1.73831146
159Decreased central vision (HP:0007663)1.72247283
160Conjunctival telangiectasia (HP:0000524)1.72162398
161Hyperglycemia (HP:0003074)1.69750124
162Osteolytic defects of the hand bones (HP:0009699)1.69169363
163Osteolytic defects of the phalanges of the hand (HP:0009771)1.69169363
164Inappropriate behavior (HP:0000719)1.68398501
165Arterial tortuosity (HP:0005116)1.68335027
166Calf muscle hypertrophy (HP:0008981)1.67962456
167Tetraparesis (HP:0002273)1.67692984
168Hypoplasia of the iris (HP:0007676)1.67162190
169Curly hair (HP:0002212)1.66526877
170Supranuclear gaze palsy (HP:0000605)1.65923650
171Insulin-resistant diabetes mellitus (HP:0000831)1.65630730
172Clumsiness (HP:0002312)1.65446738
173Hypolipoproteinemia (HP:0010981)1.65417996
174Hypokinesia (HP:0002375)1.64822784
175Generalized myoclonic seizures (HP:0002123)1.64740219
176Deep venous thrombosis (HP:0002625)1.64405648
177Polyuria (HP:0000103)1.63861208
178Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62541197
179Cupped ribs (HP:0000887)1.62410431
180Widely spaced teeth (HP:0000687)1.61799328
181Type I diabetes mellitus (HP:0100651)1.61234722
182Absent speech (HP:0001344)1.59738503
183Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59139509
184Abnormality of aspartate family amino acid metabolism (HP:0010899)1.58825137
185Facial diplegia (HP:0001349)1.58609098
186Ocular albinism (HP:0001107)1.57811675
187Abnormality of the astrocytes (HP:0100707)1.57196884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.19982735
2MAP3K143.14778296
3ACVR1B2.95988221
4FRK2.92255530
5RIPK42.66747347
6EIF2AK32.59832211
7TAOK32.53881901
8TRPM72.16929516
9FER2.07338077
10PAK31.98138044
11BMPR21.73234142
12CAMK1G1.71932620
13FGFR21.71414832
14WNK31.70254975
15GRK11.68128533
16EPHB11.65571131
17NLK1.57116940
18BRSK21.55324423
19PTK2B1.51762614
20IRAK41.50798782
21JAK11.50135127
22IRAK31.49220050
23TRIM281.47784650
24TNIK1.46889693
25MKNK21.45795111
26ERBB31.44620746
27MAP3K21.42228352
28STK38L1.41591098
29CAMK1D1.41384921
30PBK1.39790468
31PKN11.37890659
32MAP4K21.33571061
33MAPK131.33133206
34PHKG11.32322148
35PHKG21.32322148
36ADRBK21.30957811
37STK391.28630900
38WNK11.24576823
39EIF2AK11.18020480
40YES11.17944970
41MAP3K131.16467647
42MAP3K41.16097429
43NUAK11.15000789
44EPHA31.14180754
45FGFR31.11659793
46MET1.10561446
47JAK31.08551080
48PDGFRB1.07995822
49TTN1.07254083
50MST1R1.06361035
51PINK11.04785357
52STK241.04095366
53IKBKB1.01084661
54SGK20.99330074
55NTRK30.98243032
56PDK20.97351569
57TGFBR20.96817156
58SGK30.96277253
59TBK10.95200975
60CSNK1G10.94877953
61ERBB40.94226177
62FGR0.92917644
63PRKAA20.92288644
64PLK20.92076139
65CHUK0.91255231
66TYK20.91174725
67GRK70.86042668
68MAPK70.85272240
69SGK10.85008497
70NEK60.84686081
71DMPK0.83054545
72MAPK150.81389590
73DAPK20.80613691
74MARK30.80539782
75BMX0.80494563
76JAK20.80311884
77NEK90.80141986
78PIK3CA0.79863302
79IRAK10.79637732
80AKT30.78793978
81STK30.77791831
82PRKCQ0.77285935
83IKBKE0.77065313
84TXK0.76658401
85CSNK1G20.75958532
86OBSCN0.74739654
87HCK0.74427370
88PDK10.73984642
89PLK30.72611130
90LATS10.71739947
91PRKCE0.71264866
92SGK2230.71015406
93SGK4940.71015406
94WNK40.70693295
95KIT0.70264390
96PDPK10.69937811
97BMPR1B0.69630335
98CASK0.69358265
99PIK3CG0.66013356
100MAP3K30.65742483
101HIPK20.64660621
102OXSR10.62613140
103CSK0.61804377
104CAMKK20.61619904
105SCYL20.61526943
106PRKAA10.61216058
107CSNK1G30.60323793
108ADRBK10.60213777
109MAP3K60.59968100
110RET0.58745423
111ABL10.58018079
112DDR20.57234624
113CAMK2D0.57189788
114STK110.56674641
115LCK0.56362868
116PRPF4B0.55999398
117TEC0.55926610
118MST40.55623332
119CSNK1A1L0.54540523
120CSF1R0.53534356
121CLK10.53009365
122ITK0.52902449
123GSK3A0.52227237
124IRAK20.50919083
125EGFR0.49733407
126MKNK10.49653944
127MAP2K10.49459079
128IGF1R0.49353072
129PRKG10.48457780
130BCR0.48282538
131FES0.47126213
132WEE10.46987843
133LYN0.46728535
134PRKCH0.43730332
135PRKCI0.43606632
136PNCK0.43460481
137PDK30.42400040
138PDK40.42400040
139EPHA40.42061211
140MAP3K120.39302245
141KSR10.35963500
142ZAK0.34085709
143MAP2K60.31924394
144MELK0.31514555
145PRKCG0.29657462
146MAPKAPK30.29263437
147ROCK10.28826112
148CSNK1D0.28304309
149MUSK0.27346262
150CAMK2A0.26345759
151RPS6KB10.26269680
152ATM0.25214600
153MAP2K70.25098369
154CDK30.24828191
155EIF2AK20.24026939

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.05141891
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55032567
3Staphylococcus aureus infection_Homo sapiens_hsa051502.27793343
4Vitamin B6 metabolism_Homo sapiens_hsa007502.13597409
5Regulation of autophagy_Homo sapiens_hsa041401.91090139
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89698227
7Lysosome_Homo sapiens_hsa041421.88168281
8Circadian rhythm_Homo sapiens_hsa047101.81432561
9Phototransduction_Homo sapiens_hsa047441.76850837
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69236606
11Steroid biosynthesis_Homo sapiens_hsa001001.68829296
12Complement and coagulation cascades_Homo sapiens_hsa046101.65603769
13Osteoclast differentiation_Homo sapiens_hsa043801.62439456
14Selenocompound metabolism_Homo sapiens_hsa004501.60501164
15Phagosome_Homo sapiens_hsa041451.51156514
16Rheumatoid arthritis_Homo sapiens_hsa053231.46166885
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.39578216
18Type II diabetes mellitus_Homo sapiens_hsa049301.34595082
19Other glycan degradation_Homo sapiens_hsa005111.34432041
20Nitrogen metabolism_Homo sapiens_hsa009101.33209175
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31390930
22Sphingolipid metabolism_Homo sapiens_hsa006001.29189130
23Leishmaniasis_Homo sapiens_hsa051401.29110292
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28868938
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28705389
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25654439
27Caffeine metabolism_Homo sapiens_hsa002321.25594134
28Malaria_Homo sapiens_hsa051441.21455125
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.20775142
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19805577
31Dorso-ventral axis formation_Homo sapiens_hsa043201.19425757
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18805134
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16623500
34Ether lipid metabolism_Homo sapiens_hsa005651.14968293
35Tuberculosis_Homo sapiens_hsa051521.14184232
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.12732724
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12072008
38Fatty acid elongation_Homo sapiens_hsa000621.11274584
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09989105
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08200461
41TNF signaling pathway_Homo sapiens_hsa046681.07655424
42RNA degradation_Homo sapiens_hsa030181.05315514
43Basal transcription factors_Homo sapiens_hsa030221.03642301
44African trypanosomiasis_Homo sapiens_hsa051431.03303397
45ABC transporters_Homo sapiens_hsa020101.02416177
46Graft-versus-host disease_Homo sapiens_hsa053321.02272854
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98339726
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.97795809
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94500453
50Collecting duct acid secretion_Homo sapiens_hsa049660.94005889
51Type I diabetes mellitus_Homo sapiens_hsa049400.93207018
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91891247
53Sulfur metabolism_Homo sapiens_hsa009200.88123688
54Starch and sucrose metabolism_Homo sapiens_hsa005000.87639677
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86856380
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86705483
57Insulin resistance_Homo sapiens_hsa049310.86200510
58Lysine degradation_Homo sapiens_hsa003100.85925653
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84563436
60Chemokine signaling pathway_Homo sapiens_hsa040620.81946064
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81813233
62Pertussis_Homo sapiens_hsa051330.81029845
63Non-homologous end-joining_Homo sapiens_hsa034500.80499888
64PPAR signaling pathway_Homo sapiens_hsa033200.79189032
65B cell receptor signaling pathway_Homo sapiens_hsa046620.79060156
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.78967245
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76933349
68Renin secretion_Homo sapiens_hsa049240.76438833
69Histidine metabolism_Homo sapiens_hsa003400.71361850
70Amoebiasis_Homo sapiens_hsa051460.69607777
71Circadian entrainment_Homo sapiens_hsa047130.67629701
72Inositol phosphate metabolism_Homo sapiens_hsa005620.67556128
73Mineral absorption_Homo sapiens_hsa049780.67411715
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65979231
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65226819
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63558079
77Salivary secretion_Homo sapiens_hsa049700.63338394
78Platelet activation_Homo sapiens_hsa046110.62827478
79Fatty acid degradation_Homo sapiens_hsa000710.62612678
80Fanconi anemia pathway_Homo sapiens_hsa034600.61997152
81Salmonella infection_Homo sapiens_hsa051320.61458064
82Toxoplasmosis_Homo sapiens_hsa051450.61455016
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59888064
84Allograft rejection_Homo sapiens_hsa053300.58415441
85Legionellosis_Homo sapiens_hsa051340.58134080
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.56951263
87Vibrio cholerae infection_Homo sapiens_hsa051100.56626176
88Ovarian steroidogenesis_Homo sapiens_hsa049130.56175117
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55983028
90Propanoate metabolism_Homo sapiens_hsa006400.55952611
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55902957
92ECM-receptor interaction_Homo sapiens_hsa045120.55698747
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55593339
94Butanoate metabolism_Homo sapiens_hsa006500.55390584
95Peroxisome_Homo sapiens_hsa041460.55202729
96Glutamatergic synapse_Homo sapiens_hsa047240.55030117
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54299206
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54060117
99Amphetamine addiction_Homo sapiens_hsa050310.53828760
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53460383
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.53174514
102Arginine biosynthesis_Homo sapiens_hsa002200.52853682
103Long-term depression_Homo sapiens_hsa047300.52426583
104Prostate cancer_Homo sapiens_hsa052150.51971134
105Tryptophan metabolism_Homo sapiens_hsa003800.50119318
106Measles_Homo sapiens_hsa051620.49925952
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49683464
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.49594452
109Morphine addiction_Homo sapiens_hsa050320.49533491
110Linoleic acid metabolism_Homo sapiens_hsa005910.49520047
111Melanoma_Homo sapiens_hsa052180.49484663
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49428058
113Pancreatic secretion_Homo sapiens_hsa049720.48834988
114Folate biosynthesis_Homo sapiens_hsa007900.48777426
115beta-Alanine metabolism_Homo sapiens_hsa004100.48256608
116Chemical carcinogenesis_Homo sapiens_hsa052040.46724157
117Fatty acid biosynthesis_Homo sapiens_hsa000610.46338611
118Olfactory transduction_Homo sapiens_hsa047400.45714025
119Focal adhesion_Homo sapiens_hsa045100.45345081
120Dopaminergic synapse_Homo sapiens_hsa047280.45104003
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44826752
122Influenza A_Homo sapiens_hsa051640.44658050
123Homologous recombination_Homo sapiens_hsa034400.44446137
124Fatty acid metabolism_Homo sapiens_hsa012120.44227039
125Arachidonic acid metabolism_Homo sapiens_hsa005900.44214360
126Asthma_Homo sapiens_hsa053100.43592106
127Serotonergic synapse_Homo sapiens_hsa047260.43546945
128Calcium signaling pathway_Homo sapiens_hsa040200.42776912
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42398849
130FoxO signaling pathway_Homo sapiens_hsa040680.42312418
131MAPK signaling pathway_Homo sapiens_hsa040100.42302229
132Hepatitis C_Homo sapiens_hsa051600.41816221
133Prion diseases_Homo sapiens_hsa050200.41653153
134Glucagon signaling pathway_Homo sapiens_hsa049220.40953857
135mTOR signaling pathway_Homo sapiens_hsa041500.40907469
136Insulin secretion_Homo sapiens_hsa049110.40664701
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.40596361
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40419068
139Taste transduction_Homo sapiens_hsa047420.39178000
140Retinol metabolism_Homo sapiens_hsa008300.38636085
141TGF-beta signaling pathway_Homo sapiens_hsa043500.33921231
142AMPK signaling pathway_Homo sapiens_hsa041520.33053071
143Oocyte meiosis_Homo sapiens_hsa041140.32099312
144Thyroid hormone synthesis_Homo sapiens_hsa049180.30652224
145Glycerolipid metabolism_Homo sapiens_hsa005610.30411827
146Prolactin signaling pathway_Homo sapiens_hsa049170.30154435

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