FMO9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.33625706
2response to pheromone (GO:0019236)5.06666069
3L-fucose catabolic process (GO:0042355)4.72086135
4fucose catabolic process (GO:0019317)4.72086135
5L-fucose metabolic process (GO:0042354)4.72086135
6negative regulation of transcription regulatory region DNA binding (GO:2000678)4.28805929
7negative regulation of mast cell activation (GO:0033004)4.06531249
8detection of light stimulus involved in sensory perception (GO:0050962)3.60649561
9detection of light stimulus involved in visual perception (GO:0050908)3.60649561
10ATP synthesis coupled proton transport (GO:0015986)3.59465385
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59465385
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58532001
13tryptophan catabolic process (GO:0006569)3.39078540
14indole-containing compound catabolic process (GO:0042436)3.39078540
15indolalkylamine catabolic process (GO:0046218)3.39078540
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33483215
17kynurenine metabolic process (GO:0070189)3.31981874
18gamma-aminobutyric acid transport (GO:0015812)3.26958983
19positive regulation of meiosis (GO:0045836)3.20570918
20dopamine transport (GO:0015872)3.17781818
21regulation of action potential (GO:0098900)3.16010299
22postsynaptic membrane organization (GO:0001941)3.14911074
23DNA deamination (GO:0045006)3.14337752
24neuronal action potential (GO:0019228)3.10313162
25somite rostral/caudal axis specification (GO:0032525)3.09069646
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08164753
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.08164753
28NADH dehydrogenase complex assembly (GO:0010257)3.08164753
29regulation of mesenchymal cell apoptotic process (GO:2001053)3.07254735
30indolalkylamine metabolic process (GO:0006586)3.05733923
31one-carbon compound transport (GO:0019755)3.05097221
32nonmotile primary cilium assembly (GO:0035058)3.04198967
33negative regulation of telomere maintenance (GO:0032205)3.02956127
34positive regulation of meiotic cell cycle (GO:0051446)3.01773580
35somite development (GO:0061053)3.00710136
36regulation of cilium movement (GO:0003352)2.97285217
37epithelial cilium movement (GO:0003351)2.96679960
38protein complex biogenesis (GO:0070271)2.94724494
39xenobiotic catabolic process (GO:0042178)2.93264352
40auditory receptor cell stereocilium organization (GO:0060088)2.91901602
41cellular ketone body metabolic process (GO:0046950)2.90673460
42neuron fate determination (GO:0048664)2.90050102
43peristalsis (GO:0030432)2.88927290
44transmission of nerve impulse (GO:0019226)2.87729262
45piRNA metabolic process (GO:0034587)2.86225980
46platelet dense granule organization (GO:0060155)2.84798270
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83469967
48parturition (GO:0007567)2.82259139
49cellular response to ATP (GO:0071318)2.81726216
50nephron tubule morphogenesis (GO:0072078)2.81651035
51nephron epithelium morphogenesis (GO:0072088)2.81651035
52hindbrain development (GO:0030902)2.81397167
53phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80416709
54adult feeding behavior (GO:0008343)2.79423367
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78732082
56positive regulation of gastrulation (GO:2000543)2.78491237
57limb bud formation (GO:0060174)2.77353790
58regulation of neurotransmitter uptake (GO:0051580)2.74985813
59protein-cofactor linkage (GO:0018065)2.74822038
60protein polyglutamylation (GO:0018095)2.74549986
61neuronal action potential propagation (GO:0019227)2.72290155
62inner ear receptor stereocilium organization (GO:0060122)2.71398343
63tryptophan metabolic process (GO:0006568)2.70717145
64viral transcription (GO:0019083)2.70579986
65regulation of microtubule-based movement (GO:0060632)2.69461893
66fucosylation (GO:0036065)2.68734053
67sulfation (GO:0051923)2.68578992
68indole-containing compound metabolic process (GO:0042430)2.68569249
69regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65797434
70benzene-containing compound metabolic process (GO:0042537)2.64643163
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62741157
72translational termination (GO:0006415)2.61808514
73mitochondrial respiratory chain complex assembly (GO:0033108)2.59673569
74auditory behavior (GO:0031223)2.56951867
75signal transduction involved in regulation of gene expression (GO:0023019)2.56734864
76ketone body metabolic process (GO:1902224)2.56474069
77kidney morphogenesis (GO:0060993)2.56357456
78cilium movement (GO:0003341)2.56306104
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56015433
80synaptic transmission, cholinergic (GO:0007271)2.55515367
81cilium morphogenesis (GO:0060271)2.55019731
82negative regulation of appetite (GO:0032099)2.53587379
83negative regulation of response to food (GO:0032096)2.53587379
84electron transport chain (GO:0022900)2.53563671
85positive regulation of triglyceride biosynthetic process (GO:0010867)2.51985984
86proton transport (GO:0015992)2.51725596
87hydrogen ion transmembrane transport (GO:1902600)2.49380910
88midbrain development (GO:0030901)2.49323332
89cornea development in camera-type eye (GO:0061303)2.49204669
90axoneme assembly (GO:0035082)2.48875223
91detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47916329
92rhodopsin mediated signaling pathway (GO:0016056)2.47695706
93hydrogen transport (GO:0006818)2.47688314
94sex differentiation (GO:0007548)2.47681276
95serotonin metabolic process (GO:0042428)2.46693208
96negative regulation of reactive oxygen species metabolic process (GO:2000378)2.44172734
97phasic smooth muscle contraction (GO:0014821)2.43822961
98behavioral response to ethanol (GO:0048149)2.43704574
99spinal cord development (GO:0021510)2.41555307
100respiratory electron transport chain (GO:0022904)2.41322319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30233047
2ZNF274_21170338_ChIP-Seq_K562_Hela4.10115970
3VDR_22108803_ChIP-Seq_LS180_Human3.38723567
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91847123
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50302005
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43079878
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30755629
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22362259
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19121851
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.10041569
11GBX2_23144817_ChIP-Seq_PC3_Human2.06661312
12IGF1R_20145208_ChIP-Seq_DFB_Human2.04748151
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01461711
14EWS_26573619_Chip-Seq_HEK293_Human1.90638938
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89124308
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85817981
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82647216
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73468437
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.72499392
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.72344361
21ER_23166858_ChIP-Seq_MCF-7_Human1.70854714
22P300_19829295_ChIP-Seq_ESCs_Human1.70834581
23FUS_26573619_Chip-Seq_HEK293_Human1.67969999
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65411400
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.63020560
26REST_21632747_ChIP-Seq_MESCs_Mouse1.62534806
27RNF2_27304074_Chip-Seq_NSC_Mouse1.60900273
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59856541
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58581181
30BCAT_22108803_ChIP-Seq_LS180_Human1.51208698
31TP53_22573176_ChIP-Seq_HFKS_Human1.51027909
32IRF1_19129219_ChIP-ChIP_H3396_Human1.49986519
33TAF15_26573619_Chip-Seq_HEK293_Human1.49931024
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47526658
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45355594
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45355594
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44884160
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42936318
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42770790
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41172518
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40971489
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38494650
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.37740486
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36999735
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36866287
46AR_21572438_ChIP-Seq_LNCaP_Human1.35908561
47* AR_25329375_ChIP-Seq_VCAP_Human1.35225511
48MYC_18940864_ChIP-ChIP_HL60_Human1.32270927
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31712541
50* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31001862
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27976482
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27664212
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.27586550
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.25933856
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25493592
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.25493592
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24487126
58STAT3_23295773_ChIP-Seq_U87_Human1.23777279
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.23766662
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21890170
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20130021
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.20052019
63* NANOG_19829295_ChIP-Seq_ESCs_Human1.17606201
64* SOX2_19829295_ChIP-Seq_ESCs_Human1.17606201
65SMAD4_21799915_ChIP-Seq_A2780_Human1.17261066
66TCF4_22108803_ChIP-Seq_LS180_Human1.16330786
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.15966561
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15936209
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.15185756
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15113056
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14238185
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14185939
73TAF2_19829295_ChIP-Seq_ESCs_Human1.13986138
74TCF4_23295773_ChIP-Seq_U87_Human1.13458617
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13289375
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.13237333
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12504316
78* MYC_19829295_ChIP-Seq_ESCs_Human1.12324442
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12166841
80CBP_20019798_ChIP-Seq_JUKART_Human1.11968776
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11968776
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11421750
83AR_20517297_ChIP-Seq_VCAP_Human1.10755719
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09934625
85NCOR_22424771_ChIP-Seq_293T_Human1.09323518
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08373433
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.05232981
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04650727
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03831132
90NANOG_20526341_ChIP-Seq_ESCs_Human1.03391744
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03004183
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.02985938
93ERA_21632823_ChIP-Seq_H3396_Human1.02482106
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01884263
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00833854
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99385614
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.97122336
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96928733
99RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96928733
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96208030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.92730627
2MP0003011_delayed_dark_adaptation2.65812606
3MP0003880_abnormal_central_pattern2.39620373
4MP0002938_white_spotting2.33308728
5MP0002102_abnormal_ear_morphology2.29086219
6MP0002837_dystrophic_cardiac_calcinosis2.28426783
7MP0000566_synostosis2.26886964
8MP0005551_abnormal_eye_electrophysiolog2.22534143
9MP0004885_abnormal_endolymph2.19046671
10MP0000516_abnormal_urinary_system2.17791783
11MP0005367_renal/urinary_system_phenotyp2.17791783
12MP0008875_abnormal_xenobiotic_pharmacok2.17045298
13MP0001968_abnormal_touch/_nociception2.16510125
14MP0001986_abnormal_taste_sensitivity2.13607020
15MP0008872_abnormal_physiological_respon2.11634545
16MP0010386_abnormal_urinary_bladder2.07550770
17MP0006292_abnormal_olfactory_placode2.07002831
18MP0004133_heterotaxia2.03908279
19MP0002736_abnormal_nociception_after1.90458538
20MP0009379_abnormal_foot_pigmentation1.86582793
21MP0003646_muscle_fatigue1.83989743
22MP0001485_abnormal_pinna_reflex1.82214805
23MP0002234_abnormal_pharynx_morphology1.80647494
24MP0002653_abnormal_ependyma_morphology1.76956321
25MP0003283_abnormal_digestive_organ1.76912458
26MP0009745_abnormal_behavioral_response1.76816548
27MP0002735_abnormal_chemical_nociception1.69169297
28MP0005084_abnormal_gallbladder_morpholo1.66218673
29MP0006072_abnormal_retinal_apoptosis1.60554867
30MP0003195_calcinosis1.57217603
31MP0000631_abnormal_neuroendocrine_gland1.54215597
32MP0000569_abnormal_digit_pigmentation1.53614518
33MP0001486_abnormal_startle_reflex1.53143622
34MP0002272_abnormal_nervous_system1.50895947
35MP0005253_abnormal_eye_physiology1.48388925
36MP0000427_abnormal_hair_cycle1.47981523
37MP0005645_abnormal_hypothalamus_physiol1.47037617
38MP0004142_abnormal_muscle_tone1.46208804
39MP0005423_abnormal_somatic_nervous1.43006488
40MP0002733_abnormal_thermal_nociception1.42097993
41MP0003119_abnormal_digestive_system1.39138100
42MP0006276_abnormal_autonomic_nervous1.35789455
43MP0004742_abnormal_vestibular_system1.35572822
44MP0008877_abnormal_DNA_methylation1.34842054
45MP0009046_muscle_twitch1.34683869
46MP0004147_increased_porphyrin_level1.30700023
47MP0001970_abnormal_pain_threshold1.30354325
48MP0000778_abnormal_nervous_system1.29333293
49MP0002928_abnormal_bile_duct1.25698563
50MP0000026_abnormal_inner_ear1.24929857
51MP0000383_abnormal_hair_follicle1.24038226
52MP0008789_abnormal_olfactory_epithelium1.21857214
53MP0002572_abnormal_emotion/affect_behav1.19603681
54MP0008995_early_reproductive_senescence1.19431782
55MP0004145_abnormal_muscle_electrophysio1.17895559
56MP0002095_abnormal_skin_pigmentation1.17596526
57MP0005171_absent_coat_pigmentation1.17087098
58MP0002064_seizures1.16004546
59MP0002557_abnormal_social/conspecific_i1.15869979
60MP0001756_abnormal_urination1.15420451
61MP0002876_abnormal_thyroid_physiology1.15321523
62MP0002638_abnormal_pupillary_reflex1.15179565
63MP0003938_abnormal_ear_development1.10657011
64MP0005075_abnormal_melanosome_morpholog1.09982628
65MP0004043_abnormal_pH_regulation1.08398443
66MP0002160_abnormal_reproductive_system1.08149877
67MP0001293_anophthalmia1.07554734
68MP0001346_abnormal_lacrimal_gland1.07483917
69MP0005195_abnormal_posterior_eye1.06647213
70MP0002734_abnormal_mechanical_nocicepti1.05145697
71MP0002163_abnormal_gland_morphology1.05058231
72MP0001501_abnormal_sleep_pattern1.04842994
73MP0000049_abnormal_middle_ear1.04805539
74MP0005646_abnormal_pituitary_gland1.04076722
75MP0000647_abnormal_sebaceous_gland1.03119810
76MP0005389_reproductive_system_phenotype1.02466831
77MP0001440_abnormal_grooming_behavior1.01136530
78MP0001905_abnormal_dopamine_level1.00186381
79MP0002067_abnormal_sensory_capabilities0.97464992
80MP0002752_abnormal_somatic_nervous0.97321172
81MP0001324_abnormal_eye_pigmentation0.97160771
82MP0000534_abnormal_ureter_morphology0.96378828
83MP0002282_abnormal_trachea_morphology0.95885778
84MP0003252_abnormal_bile_duct0.94780594
85MP0001919_abnormal_reproductive_system0.93574732
86MP0003890_abnormal_embryonic-extraembry0.92022307
87MP0001984_abnormal_olfaction0.91275946
88MP0002277_abnormal_respiratory_mucosa0.90139206
89MP0003635_abnormal_synaptic_transmissio0.89670180
90MP0000372_irregular_coat_pigmentation0.89406664
91MP0001529_abnormal_vocalization0.86783061
92MP0002063_abnormal_learning/memory/cond0.86700126
93MP0004924_abnormal_behavior0.86535912
94MP0005386_behavior/neurological_phenoty0.86535912
95MP0000470_abnormal_stomach_morphology0.81507781
96MP0005391_vision/eye_phenotype0.81193031
97MP0001963_abnormal_hearing_physiology0.80126920
98MP0010030_abnormal_orbit_morphology0.80032913
99MP0005503_abnormal_tendon_morphology0.79030305
100MP0002184_abnormal_innervation0.78987161

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.28964302
2Pancreatic fibrosis (HP:0100732)4.11367981
3Pancreatic cysts (HP:0001737)4.09446859
4Concave nail (HP:0001598)3.88507609
5Congenital stationary night blindness (HP:0007642)3.81769097
6Abnormality of midbrain morphology (HP:0002418)3.38626644
7Molar tooth sign on MRI (HP:0002419)3.38626644
8Rib fusion (HP:0000902)3.33512236
9Hyperventilation (HP:0002883)3.30792648
10Nephronophthisis (HP:0000090)3.22661421
11Type II lissencephaly (HP:0007260)3.20043444
12Attenuation of retinal blood vessels (HP:0007843)2.99032846
13Abnormal number of erythroid precursors (HP:0012131)2.96171308
14Tubular atrophy (HP:0000092)2.95015977
15Abnormality of the renal cortex (HP:0011035)2.94071833
16Abnormality of the renal medulla (HP:0100957)2.88016853
17Keratoconus (HP:0000563)2.87807825
18Increased corneal curvature (HP:0100692)2.87807825
19Pendular nystagmus (HP:0012043)2.87680225
20Oligodactyly (hands) (HP:0001180)2.79344970
21Abolished electroretinogram (ERG) (HP:0000550)2.74297194
22Focal motor seizures (HP:0011153)2.71103799
23Sclerocornea (HP:0000647)2.60733272
24Medial flaring of the eyebrow (HP:0010747)2.60264042
25Abnormality of cells of the erythroid lineage (HP:0012130)2.59099083
26Cystic liver disease (HP:0006706)2.57886399
27Congenital, generalized hypertrichosis (HP:0004540)2.54003123
28Patellar aplasia (HP:0006443)2.47610861
29Bilateral microphthalmos (HP:0007633)2.46640946
30Decreased central vision (HP:0007663)2.45587549
31Cerebellar dysplasia (HP:0007033)2.45170331
32Abnormal respiratory motile cilium morphology (HP:0005938)2.43136894
33Abnormal respiratory epithelium morphology (HP:0012253)2.43136894
34Aplasia/Hypoplasia of the patella (HP:0006498)2.41652120
35Inability to walk (HP:0002540)2.39077386
36Anencephaly (HP:0002323)2.36804114
37Abnormal rod and cone electroretinograms (HP:0008323)2.30454851
38Mitochondrial inheritance (HP:0001427)2.28540078
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28321046
40Abnormality of alanine metabolism (HP:0010916)2.28321046
41Hyperalaninemia (HP:0003348)2.28321046
42Bony spicule pigmentary retinopathy (HP:0007737)2.27836511
43Chorioretinal atrophy (HP:0000533)2.27405392
44Abnormal drinking behavior (HP:0030082)2.26939974
45Polydipsia (HP:0001959)2.26939974
46Septo-optic dysplasia (HP:0100842)2.16508992
47Furrowed tongue (HP:0000221)2.16100548
48Progressive cerebellar ataxia (HP:0002073)2.15293050
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.10331338
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10203205
51Hepatocellular necrosis (HP:0001404)2.10002334
52Aplasia/hypoplasia of the uterus (HP:0008684)2.09815784
53Male pseudohermaphroditism (HP:0000037)2.08579629
54Esophageal atresia (HP:0002032)2.06786874
55Oligodactyly (HP:0012165)2.05799501
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05543692
57Polyuria (HP:0000103)2.04831466
58Absent/shortened dynein arms (HP:0200106)2.03203646
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.03203646
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02349174
61Congenital hepatic fibrosis (HP:0002612)2.00829293
62Synostosis involving the elbow (HP:0003938)1.99814027
63Humeroradial synostosis (HP:0003041)1.99814027
64Acute necrotizing encephalopathy (HP:0006965)1.97698400
65Mesangial abnormality (HP:0001966)1.97623302
66Gait imbalance (HP:0002141)1.96669591
67Broad-based gait (HP:0002136)1.96623243
68Increased CSF lactate (HP:0002490)1.96341498
69Optic nerve hypoplasia (HP:0000609)1.93759816
70Large for gestational age (HP:0001520)1.93414573
71Hemiparesis (HP:0001269)1.93387634
72Chronic hepatic failure (HP:0100626)1.92820894
73Nephrogenic diabetes insipidus (HP:0009806)1.92665169
74Renal cortical cysts (HP:0000803)1.92141243
75Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91685646
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91257433
77Retinal dysplasia (HP:0007973)1.90911163
78Hepatic necrosis (HP:0002605)1.90779913
79Occipital encephalocele (HP:0002085)1.90647882
80Congenital primary aphakia (HP:0007707)1.90368976
813-Methylglutaconic aciduria (HP:0003535)1.89712006
82Lissencephaly (HP:0001339)1.83150620
83Progressive inability to walk (HP:0002505)1.82240121
84Severe muscular hypotonia (HP:0006829)1.81719321
85Optic disc pallor (HP:0000543)1.81371502
86Abnormality of the labia minora (HP:0012880)1.80864705
87Hyperglycinuria (HP:0003108)1.79586066
88Abnormal ciliary motility (HP:0012262)1.78379570
89Clumsiness (HP:0002312)1.75445703
90Split foot (HP:0001839)1.75264204
91Genital tract atresia (HP:0001827)1.75180490
92Postaxial foot polydactyly (HP:0001830)1.74822679
93Vaginal atresia (HP:0000148)1.72050963
94Focal seizures (HP:0007359)1.71166435
95Bulbous nose (HP:0000414)1.71122804
96Acute encephalopathy (HP:0006846)1.70679229
97Abnormal mitochondria in muscle tissue (HP:0008316)1.70402083
98Gastrointestinal atresia (HP:0002589)1.70380859
99Calf muscle hypertrophy (HP:0008981)1.66340030
100Absent speech (HP:0001344)1.65897228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.75349602
2CASK3.35408767
3ADRBK23.18454127
4TLK13.11822763
5ZAK2.98842386
6BMPR1B2.86946431
7WNK42.72716268
8WNK32.70228650
9VRK22.50549883
10INSRR2.48880818
11PINK12.44025125
12GRK12.30371793
13NUAK12.28147335
14DAPK22.18935462
15MAPK151.92813343
16PNCK1.73298244
17TNIK1.69075761
18VRK11.67495605
19MAPK131.64797253
20TGFBR11.63085513
21TAOK31.60614655
22MAP4K21.49897518
23ADRBK11.36941404
24MAPKAPK51.36315677
25STK391.33800335
26FGFR21.31370318
27ACVR1B1.31106545
28TXK1.24622318
29OXSR11.21718622
30MAP3K41.19886937
31STK38L1.17096320
32CAMKK21.16536333
33EPHB21.14818582
34DYRK21.12256747
35NEK21.06130624
36PRKCG1.04875528
37MAP2K71.04487054
38NTRK21.04122488
39MARK11.02684426
40SIK21.01601236
41CDK80.97126233
42PRKCE0.95344373
43EPHA40.90658048
44MUSK0.90337216
45GRK50.85820072
46IRAK10.84475207
47PASK0.82363869
48TAF10.78414255
49STK110.76831923
50KIT0.76437206
51PIK3CA0.73152286
52PKN10.71417684
53CDK190.69236439
54PRKCQ0.66358962
55RPS6KA50.63188918
56CHEK20.58630864
57PLK20.58547969
58NTRK30.58369877
59BRSK20.56308170
60PRKACA0.55977344
61STK160.55395754
62MKNK20.55110088
63TIE10.54834305
64CAMKK10.54817514
65TYRO30.52746935
66STK30.52552840
67CAMK10.52014716
68PTK2B0.51826554
69GRK70.50312947
70PLK30.50050200
71IKBKB0.49576541
72PRKCZ0.49112220
73WEE10.47943500
74PLK40.47863122
75ATR0.46287711
76NME10.45800056
77SYK0.45538585
78PAK30.45159408
79PDK20.44632989
80PRKCI0.44160391
81CSNK1A10.43429703
82PRKCA0.43303884
83PHKG20.41418715
84PHKG10.41418715
85NLK0.40455793
86CAMK2A0.38593739
87CSNK1G20.38203608
88DYRK1A0.37935725
89STK380.37516691
90RPS6KA60.36966843
91MAP3K70.36608972
92CHUK0.33024428
93OBSCN0.32515742
94PRKG10.30470534
95SGK20.28494087
96IKBKE0.28301233
97CSNK1D0.27572450
98MKNK10.26836354
99SGK4940.24212754
100SGK2230.24212754

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.13528342
2Linoleic acid metabolism_Homo sapiens_hsa005913.01547788
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95514096
4Phototransduction_Homo sapiens_hsa047442.75713883
5Ribosome_Homo sapiens_hsa030102.59915074
6Parkinsons disease_Homo sapiens_hsa050122.56938592
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.51522870
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23747188
9Butanoate metabolism_Homo sapiens_hsa006502.18666794
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11644477
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07035849
12Nicotine addiction_Homo sapiens_hsa050331.98518149
13Nitrogen metabolism_Homo sapiens_hsa009101.94641125
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88925090
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88432480
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84482717
17Ether lipid metabolism_Homo sapiens_hsa005651.83107257
18Cardiac muscle contraction_Homo sapiens_hsa042601.82564643
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81201456
20Huntingtons disease_Homo sapiens_hsa050161.72476376
21RNA polymerase_Homo sapiens_hsa030201.69813383
22Tryptophan metabolism_Homo sapiens_hsa003801.68977805
23Alzheimers disease_Homo sapiens_hsa050101.62664153
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62228522
25Selenocompound metabolism_Homo sapiens_hsa004501.58845705
26Olfactory transduction_Homo sapiens_hsa047401.52584715
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48710615
28Protein export_Homo sapiens_hsa030601.46482056
29Chemical carcinogenesis_Homo sapiens_hsa052041.43931596
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41741686
31Caffeine metabolism_Homo sapiens_hsa002321.41254395
32Arachidonic acid metabolism_Homo sapiens_hsa005901.37655784
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.32248826
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.31393647
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.30047928
36Fanconi anemia pathway_Homo sapiens_hsa034601.22934374
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22017593
38Asthma_Homo sapiens_hsa053101.21504259
39Morphine addiction_Homo sapiens_hsa050321.19111056
40Taste transduction_Homo sapiens_hsa047421.16108973
41Basal transcription factors_Homo sapiens_hsa030221.15469271
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11638435
43Collecting duct acid secretion_Homo sapiens_hsa049661.10070447
44Homologous recombination_Homo sapiens_hsa034401.08255504
45ABC transporters_Homo sapiens_hsa020101.04271308
46Fat digestion and absorption_Homo sapiens_hsa049751.03266984
47Retinol metabolism_Homo sapiens_hsa008300.99086531
48Basal cell carcinoma_Homo sapiens_hsa052170.99000198
49One carbon pool by folate_Homo sapiens_hsa006700.97714488
50Propanoate metabolism_Homo sapiens_hsa006400.95560649
51Histidine metabolism_Homo sapiens_hsa003400.93649662
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86418583
53Insulin secretion_Homo sapiens_hsa049110.85490651
54Cocaine addiction_Homo sapiens_hsa050300.84958258
55RNA degradation_Homo sapiens_hsa030180.84285572
56Glutamatergic synapse_Homo sapiens_hsa047240.84233333
57Serotonergic synapse_Homo sapiens_hsa047260.83393005
58Peroxisome_Homo sapiens_hsa041460.81701228
59Circadian entrainment_Homo sapiens_hsa047130.77697866
60Ovarian steroidogenesis_Homo sapiens_hsa049130.77098599
61beta-Alanine metabolism_Homo sapiens_hsa004100.75153304
62GABAergic synapse_Homo sapiens_hsa047270.73512323
63Hedgehog signaling pathway_Homo sapiens_hsa043400.73063562
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69659398
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67928572
66Glycerolipid metabolism_Homo sapiens_hsa005610.67258328
67Graft-versus-host disease_Homo sapiens_hsa053320.66805230
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65588296
69Primary immunodeficiency_Homo sapiens_hsa053400.64151724
70Sulfur relay system_Homo sapiens_hsa041220.64037544
71Amphetamine addiction_Homo sapiens_hsa050310.59856058
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58209508
73Type I diabetes mellitus_Homo sapiens_hsa049400.58197746
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56876142
75Calcium signaling pathway_Homo sapiens_hsa040200.55545846
76Autoimmune thyroid disease_Homo sapiens_hsa053200.55434276
77Dopaminergic synapse_Homo sapiens_hsa047280.55009632
78Allograft rejection_Homo sapiens_hsa053300.53971909
79Metabolic pathways_Homo sapiens_hsa011000.53492291
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49348832
81Salivary secretion_Homo sapiens_hsa049700.48434076
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48151320
83Purine metabolism_Homo sapiens_hsa002300.45799189
84Mineral absorption_Homo sapiens_hsa049780.44843083
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44743479
86Tyrosine metabolism_Homo sapiens_hsa003500.44228367
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42451261
88Glutathione metabolism_Homo sapiens_hsa004800.42208903
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.39587866
90Regulation of autophagy_Homo sapiens_hsa041400.39123603
91Rheumatoid arthritis_Homo sapiens_hsa053230.36084319
92Folate biosynthesis_Homo sapiens_hsa007900.34945940
93cAMP signaling pathway_Homo sapiens_hsa040240.34598161
94Vitamin digestion and absorption_Homo sapiens_hsa049770.34378274
95Axon guidance_Homo sapiens_hsa043600.32701414
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32385771
97Antigen processing and presentation_Homo sapiens_hsa046120.31492147
98Pyruvate metabolism_Homo sapiens_hsa006200.30774385
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30006039
100Thyroid hormone synthesis_Homo sapiens_hsa049180.28702753

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