FLT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cell migration involved in sprouting angiogenesis (GO:0090049)6.05389087
2negative regulation of fibrinolysis (GO:0051918)5.73290585
3Notch signaling involved in heart development (GO:0061314)5.55695376
4patterning of blood vessels (GO:0001569)5.33396744
5* lymph vessel development (GO:0001945)5.29540925
6positive regulation of endothelial cell differentiation (GO:0045603)5.25541328
7ventricular trabecula myocardium morphogenesis (GO:0003222)5.14642362
8endothelium development (GO:0003158)5.06413786
9angiogenesis involved in wound healing (GO:0060055)4.97713829
10regulation of fibrinolysis (GO:0051917)4.97291596
11transcytosis (GO:0045056)4.91256413
12* vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.91232408
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.76874239
14L-phenylalanine catabolic process (GO:0006559)4.76874239
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.61088643
16L-phenylalanine metabolic process (GO:0006558)4.61088643
17* vascular endothelial growth factor signaling pathway (GO:0038084)4.59302730
18embryonic heart tube development (GO:0035050)4.57922628
19heart trabecula morphogenesis (GO:0061384)4.57268125
20interleukin-6-mediated signaling pathway (GO:0070102)4.56022021
21protein carboxylation (GO:0018214)4.47681860
22peptidyl-glutamic acid carboxylation (GO:0017187)4.47681860
23regulation of blood vessel endothelial cell migration (GO:0043535)4.45811643
24high-density lipoprotein particle remodeling (GO:0034375)4.44995398
25glomerular filtration (GO:0003094)4.39516625
26trabecula morphogenesis (GO:0061383)4.38813835
27blood vessel endothelial cell migration (GO:0043534)4.32471109
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.31421096
29* cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.29836434
30* lymphangiogenesis (GO:0001946)4.25984269
31alpha-linolenic acid metabolic process (GO:0036109)4.23064452
32negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.22252753
33regulation of protein activation cascade (GO:2000257)4.15047099
34aromatic amino acid family catabolic process (GO:0009074)4.13880631
35* sprouting angiogenesis (GO:0002040)4.13045541
36vasculogenesis (GO:0001570)4.08455938
37positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.06414789
38reverse cholesterol transport (GO:0043691)4.05597406
39regulation of complement activation (GO:0030449)3.95901832
40Notch receptor processing (GO:0007220)3.95300101
41glyoxylate metabolic process (GO:0046487)3.94663155
42renal filtration (GO:0097205)3.94397956
43positive regulation of vasculogenesis (GO:2001214)3.93538270
44sexual reproduction (GO:0019953)3.89241119
45kynurenine metabolic process (GO:0070189)3.86553875
46negative regulation of epithelial cell migration (GO:0010633)3.85460153
47estrogen biosynthetic process (GO:0006703)3.83966955
48retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82133123
49bile acid biosynthetic process (GO:0006699)3.81095989
50negative regulation of blood vessel endothelial cell migration (GO:0043537)3.77858203
51coronary vasculature morphogenesis (GO:0060977)3.77631744
52surfactant homeostasis (GO:0043129)3.77621751
53cell migration involved in sprouting angiogenesis (GO:0002042)3.76354978
54heart valve formation (GO:0003188)3.75223148
55acylglycerol homeostasis (GO:0055090)3.70418662
56triglyceride homeostasis (GO:0070328)3.70418662
57semaphorin-plexin signaling pathway (GO:0071526)3.69459493
58phospholipid homeostasis (GO:0055091)3.69003356
59complement activation, alternative pathway (GO:0006957)3.66187713
60drug catabolic process (GO:0042737)3.66185079
61blood vessel remodeling (GO:0001974)3.60894009
62indole-containing compound catabolic process (GO:0042436)3.60832501
63indolalkylamine catabolic process (GO:0046218)3.60832501
64tryptophan catabolic process (GO:0006569)3.60832501
65endothelial tube morphogenesis (GO:0061154)3.59546048
66morphogenesis of an endothelium (GO:0003159)3.59546048
67artery development (GO:0060840)3.57845740
68negative regulation of angiogenesis (GO:0016525)3.55794243
69plasma lipoprotein particle remodeling (GO:0034369)3.55494844
70protein-lipid complex remodeling (GO:0034368)3.55494844
71macromolecular complex remodeling (GO:0034367)3.55494844
72blood coagulation, intrinsic pathway (GO:0007597)3.53799626
73negative regulation of hemostasis (GO:1900047)3.53664887
74negative regulation of blood coagulation (GO:0030195)3.53664887
75basement membrane organization (GO:0071711)3.53652164
76exogenous drug catabolic process (GO:0042738)3.53416530
77nephron epithelium development (GO:0072009)3.53296983
78chemical homeostasis within a tissue (GO:0048875)3.52890513
79fibrinolysis (GO:0042730)3.52119340
80lysine catabolic process (GO:0006554)3.51328037
81lysine metabolic process (GO:0006553)3.51328037
82labyrinthine layer development (GO:0060711)3.49987195
83positive regulation of hemostasis (GO:1900048)3.49134322
84positive regulation of blood coagulation (GO:0030194)3.49134322
85aorta morphogenesis (GO:0035909)3.48440889
86negative regulation of endothelial cell apoptotic process (GO:2000352)3.48107564
87plasma lipoprotein particle clearance (GO:0034381)3.47062105
88sulfur amino acid catabolic process (GO:0000098)3.46830181
89tryptophan metabolic process (GO:0006568)3.45483316
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44781904
91regulation of synapse maturation (GO:0090128)3.42424350
92* regulation of endothelial cell migration (GO:0010594)3.42303579
93regulation of endothelial cell differentiation (GO:0045601)3.42296786
94negative regulation of blood vessel morphogenesis (GO:2000181)3.39430277
95regulation of triglyceride catabolic process (GO:0010896)3.39103472
96urea cycle (GO:0000050)3.38986316
97urea metabolic process (GO:0019627)3.38986316
98cAMP biosynthetic process (GO:0006171)3.37869911
99potassium ion import (GO:0010107)3.35543629
100protein activation cascade (GO:0072376)3.34235054
101regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.32581527
102wound healing, spreading of epidermal cells (GO:0035313)3.32578353
103positive regulation of coagulation (GO:0050820)3.31392275
104positive regulation of odontogenesis (GO:0042482)3.30110293
105positive regulation of astrocyte differentiation (GO:0048711)3.29230457
106negative regulation of coagulation (GO:0050819)3.25813588
107bile acid metabolic process (GO:0008206)3.25532556
108hyaluronan catabolic process (GO:0030214)3.24774529
109negative regulation of vasculature development (GO:1901343)3.24754002
110positive regulation of receptor recycling (GO:0001921)3.24533114
111substrate-dependent cell migration (GO:0006929)3.23924966
112endothelial cell differentiation (GO:0045446)3.22467497
113peptidyl-tyrosine autophosphorylation (GO:0038083)3.20889593
114endocrine hormone secretion (GO:0060986)3.20761803
115protein kinase C signaling (GO:0070528)3.20112243
116arginine metabolic process (GO:0006525)3.19588949
117positive regulation of urine volume (GO:0035810)3.18754141
118cysteine metabolic process (GO:0006534)3.16990632
119negative regulation of endothelial cell migration (GO:0010596)3.16495786
120regulation of vasculogenesis (GO:2001212)3.15930816
121homocysteine metabolic process (GO:0050667)3.13552333
122phospholipid efflux (GO:0033700)3.13422674
123neuron remodeling (GO:0016322)3.13382409
124response to follicle-stimulating hormone (GO:0032354)3.12803727
125* blood vessel morphogenesis (GO:0048514)3.11118209
126neuron projection extension involved in neuron projection guidance (GO:1902284)3.10802399
127axon extension involved in axon guidance (GO:0048846)3.10802399
128positive regulation of triglyceride lipase activity (GO:0061365)3.10648166
129positive regulation of lipoprotein lipase activity (GO:0051006)3.10648166
130negative regulation of lipase activity (GO:0060192)3.08707018
131regulation of cholesterol esterification (GO:0010872)3.08059086
132atrioventricular valve morphogenesis (GO:0003181)3.07695024
133cholesterol catabolic process (GO:0006707)3.07656633
134sterol catabolic process (GO:0016127)3.07656633
135amino-acid betaine metabolic process (GO:0006577)3.07103788
136negative regulation of platelet activation (GO:0010544)3.06947018
137cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.06820661
138* angiogenesis (GO:0001525)3.06595482
139nitrogen cycle metabolic process (GO:0071941)3.05785354
140endothelial cell morphogenesis (GO:0001886)3.04757797
141negative regulation of wound healing (GO:0061045)3.04376668
142apoptotic process involved in morphogenesis (GO:0060561)3.03756181
143heart trabecula formation (GO:0060347)3.03449512
144serine family amino acid catabolic process (GO:0009071)3.02737036
145endothelial cell chemotaxis (GO:0035767)3.02102200
146glucocorticoid biosynthetic process (GO:0006704)3.01272724
147cholesterol homeostasis (GO:0042632)3.00875736
148blood vessel maturation (GO:0001955)3.00469093
149tyrosine metabolic process (GO:0006570)2.98675449
150bile acid and bile salt transport (GO:0015721)2.98482383
151regulation of cardioblast differentiation (GO:0051890)2.98145859
152lipoprotein metabolic process (GO:0042157)2.97454055
153sterol homeostasis (GO:0055092)2.97025511
154alpha-amino acid catabolic process (GO:1901606)2.95563448
155endothelial cell migration (GO:0043542)2.92918851
156endothelial cell proliferation (GO:0001935)2.91894684
157regulation of glomerular filtration (GO:0003093)2.90485060
158positive regulation of blood vessel endothelial cell migration (GO:0043536)2.90210288
159adherens junction assembly (GO:0034333)2.89792620
160cell migration involved in heart development (GO:0060973)2.84767847
161negative regulation of cell junction assembly (GO:1901889)2.81708817
162negative regulation of adherens junction organization (GO:1903392)2.81708817
163negative regulation of focal adhesion assembly (GO:0051895)2.81708817
164cell surface receptor signaling pathway involved in heart development (GO:0061311)2.81462822
165venous blood vessel morphogenesis (GO:0048845)2.79897052
166* positive regulation of endothelial cell migration (GO:0010595)2.79870527
167negative regulation of DNA biosynthetic process (GO:2000279)2.77065787
168glomerular basement membrane development (GO:0032836)2.70873543
169negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.70150727
170ovulation from ovarian follicle (GO:0001542)2.67871794
171* regulation of epithelial cell migration (GO:0010632)2.67469275
172positive regulation of glomerulus development (GO:0090193)2.66082492
173female pregnancy (GO:0007565)2.65829796
174negative regulation of actin filament bundle assembly (GO:0032232)2.65341267
175cardiac muscle tissue development (GO:0048738)2.61977993
176insulin-like growth factor receptor signaling pathway (GO:0048009)2.61025398
177artery morphogenesis (GO:0048844)2.60463160
178establishment of endothelial barrier (GO:0061028)2.60329028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.81961954
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.44967947
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.44904814
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.39614952
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.72475342
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.60768043
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.99368684
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.40767403
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.34965867
10CLOCK_20551151_ChIP-Seq_293T_Human3.34107971
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.93673787
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93159861
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.58169354
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.57293609
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44936459
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41922083
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36970970
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36480931
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17228306
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12796669
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12796669
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.10900447
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08526928
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08014308
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08014308
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08014308
27KDM2B_26808549_Chip-Seq_DND41_Human1.93819733
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.89780758
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87024236
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.80417603
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79406115
32TCF7_22412390_ChIP-Seq_EML_Mouse1.76745272
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75862107
34ZNF263_19887448_ChIP-Seq_K562_Human1.75386755
35CTCF_27219007_Chip-Seq_Bcells_Human1.72374479
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71447003
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.69732556
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68798908
39P68_20966046_ChIP-Seq_HELA_Human1.63512194
40* EED_16625203_ChIP-ChIP_MESCs_Mouse1.61181928
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.61144690
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60487790
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56924034
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56731097
45SCL_19346495_ChIP-Seq_HPC-7_Human1.56677698
46* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54316113
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54269747
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.47305937
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46849309
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45522716
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.42791192
52VDR_21846776_ChIP-Seq_THP-1_Human1.42664553
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42292159
54* DROSHA_22980978_ChIP-Seq_HELA_Human1.40916063
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.39886647
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.39368441
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39137422
58GATA1_19941826_ChIP-Seq_K562_Human1.38520289
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37656717
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.36669841
61TBX20_22328084_ChIP-Seq_HEART_Mouse1.36669841
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.36440786
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.35600730
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.34998566
65* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34315399
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.34071862
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33046071
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30178683
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.29298185
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.28967965
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28131164
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27386180
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25359119
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24630901
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.24019934
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23774232
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23492692
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23024890
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22619660
80GATA1_22025678_ChIP-Seq_K562_Human1.21379929
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21149477
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19869842
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16696455
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16596863
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16158957
86SMC4_20622854_ChIP-Seq_HELA_Human1.14844763
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12075628
88LXR_22292898_ChIP-Seq_THP-1_Human1.11542372
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11371028
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10598202
91* RNF2_27304074_Chip-Seq_ESCs_Mouse1.10472834
92SOX2_20726797_ChIP-Seq_SW620_Human1.10384344
93TP63_22573176_ChIP-Seq_HFKS_Human1.09922238
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.09276333
95MYC_27129775_Chip-Seq_CORNEA_Mouse1.08785709
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08579529
97* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06537133
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.06136854
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05702306
100BCL6_27268052_Chip-Seq_Bcells_Human1.05139680
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04683892
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.04084541
103RACK7_27058665_Chip-Seq_MCF-7_Human1.03640601
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03610290
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03177321
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02522031
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02421457
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02267518
109CREB1_26743006_Chip-Seq_LNCaP_Human1.02220780
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01753622
111TP53_22127205_ChIP-Seq_IMR90_Human1.01675778
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01435226
113PHF8_20622854_ChIP-Seq_HELA_Human1.01227716
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00954477
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98460747
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98348330
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.98105790
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97924398
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.97332483
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97267490
121CJUN_26792858_Chip-Seq_BT549_Human0.92611117
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91425879
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90141377
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87968907
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87796139
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87796139
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87683825
128HNF4A_19822575_ChIP-Seq_HepG2_Human0.85553853
129* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84899577
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82878132
131* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81438840
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80885694
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80121401
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80085319
135SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79477449
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78428544
137* ESR1_20079471_ChIP-ChIP_T-47D_Human0.78303944
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77914650
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77316742
140GATA4_25053715_ChIP-Seq_YYC3_Human0.77020791
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76916089
142GATA2_19941826_ChIP-Seq_K562_Human0.75035945
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73251021
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73251021
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67299577
146ATF3_27146783_Chip-Seq_COLON_Human0.67060586
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.65619129
148KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65463770
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.64900270
150KDM2B_26808549_Chip-Seq_K562_Human0.63220320
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63176979
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62278596
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62040761
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.62036408
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61680913
156ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.60818825
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60760743
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60263997
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.59265499
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.58956059
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.58704578
162WT1_19549856_ChIP-ChIP_CCG9911_Human0.58417599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.59856424
2* MP0010368_abnormal_lymphatic_system5.24123830
3* MP0001879_abnormal_lymphatic_vessel4.77148366
4MP0003724_increased_susceptibility_to4.36800433
5MP0002139_abnormal_hepatobiliary_system4.21619112
6MP0005360_urolithiasis4.09812942
7MP0005085_abnormal_gallbladder_physiolo3.56811992
8MP0005365_abnormal_bile_salt3.38554577
9MP0004272_abnormal_basement_membrane3.30506003
10MP0008004_abnormal_stomach_pH3.21055651
11MP0005167_abnormal_blood-brain_barrier2.94503149
12MP0003300_gastrointestinal_ulcer2.69419377
13MP0008875_abnormal_xenobiotic_pharmacok2.67161181
14MP0010329_abnormal_lipoprotein_level2.34801013
15MP0003252_abnormal_bile_duct2.30458907
16MP0004215_abnormal_myocardial_fiber2.12071440
17MP0004782_abnormal_surfactant_physiolog2.04423576
18MP0003705_abnormal_hypodermis_morpholog1.84394302
19MP0000751_myopathy1.83285023
20MP0004084_abnormal_cardiac_muscle1.80697129
21MP0003806_abnormal_nucleotide_metabolis1.77147082
22MP0005083_abnormal_biliary_tract1.75822930
23MP0003191_abnormal_cellular_cholesterol1.75590117
24MP0001851_eye_inflammation1.74960760
25MP0002249_abnormal_larynx_morphology1.73303512
26MP0002138_abnormal_hepatobiliary_system1.71518004
27MP0010030_abnormal_orbit_morphology1.67109120
28MP0004130_abnormal_muscle_cell1.65514699
29MP0009840_abnormal_foam_cell1.63548304
30MP0002933_joint_inflammation1.59429077
31MP0003828_pulmonary_edema1.57374290
32MP0005670_abnormal_white_adipose1.54162391
33MP0000609_abnormal_liver_physiology1.52164245
34MP0000678_abnormal_parathyroid_gland1.50596158
35MP0001849_ear_inflammation1.45513851
36MP0000767_abnormal_smooth_muscle1.41372554
37MP0008438_abnormal_cutaneous_collagen1.38586099
38MP0001915_intracranial_hemorrhage1.36347634
39MP0005319_abnormal_enzyme/_coenzyme1.34352514
40* MP0000003_abnormal_adipose_tissue1.33971061
41MP0004484_altered_response_of1.33079829
42MP0000465_gastrointestinal_hemorrhage1.31690218
43MP0005332_abnormal_amino_acid1.31069976
44MP0000537_abnormal_urethra_morphology1.30694976
45MP0000249_abnormal_blood_vessel1.21414434
46MP0003279_aneurysm1.20049913
47MP0004019_abnormal_vitamin_homeostasis1.19957345
48MP0006138_congestive_heart_failure1.19545686
49MP0000049_abnormal_middle_ear1.18756493
50MP0009697_abnormal_copulation1.18079617
51MP0003566_abnormal_cell_adhesion1.17921314
52MP0001666_abnormal_nutrient_absorption1.17401628
53MP0005409_darkened_coat_color1.17168790
54MP0002118_abnormal_lipid_homeostasis1.17104060
55MP0005595_abnormal_vascular_smooth1.14104226
56* MP0005375_adipose_tissue_phenotype1.14085512
57MP0005165_increased_susceptibility_to1.08964435
58* MP0002128_abnormal_blood_circulation1.08940258
59MP0004145_abnormal_muscle_electrophysio1.06093705
60MP0004036_abnormal_muscle_relaxation1.03298205
61MP0002837_dystrophic_cardiac_calcinosis1.00294210
62MP0002332_abnormal_exercise_endurance1.00276212
63MP0002932_abnormal_joint_morphology1.00255155
64MP0009763_increased_sensitivity_to1.00246589
65MP0001544_abnormal_cardiovascular_syste0.99792199
66MP0005385_cardiovascular_system_phenoty0.99792199
67MP0002108_abnormal_muscle_morphology0.99307429
68MP0000343_altered_response_to0.98846700
69MP0002295_abnormal_pulmonary_circulatio0.97791809
70MP0005164_abnormal_response_to0.97789400
71MP0003303_peritoneal_inflammation0.97499882
72MP0006276_abnormal_autonomic_nervous0.97388198
73MP0010630_abnormal_cardiac_muscle0.96756862
74* MP0000598_abnormal_liver_morphology0.96744177
75MP0002127_abnormal_cardiovascular_syste0.95008920
76MP0009764_decreased_sensitivity_to0.93988638
77MP0002697_abnormal_eye_size0.90457150
78MP0005330_cardiomyopathy0.90046003
79* MP0003984_embryonic_growth_retardation0.89776921
80MP0000681_abnormal_thyroid_gland0.89633993
81* MP0001614_abnormal_blood_vessel0.89352885
82MP0004147_increased_porphyrin_level0.88641487
83* MP0002086_abnormal_extraembryonic_tissu0.87905568
84MP0000733_abnormal_muscle_development0.87877024
85MP0008775_abnormal_heart_ventricle0.86489666
86MP0004085_abnormal_heartbeat0.86400391
87* MP0001784_abnormal_fluid_regulation0.85813663
88* MP0002925_abnormal_cardiovascular_devel0.85775024
89* MP0002088_abnormal_embryonic_growth/wei0.85080970
90MP0002254_reproductive_system_inflammat0.83837258
91MP0002092_abnormal_eye_morphology0.82104872
92MP0003935_abnormal_craniofacial_develop0.80857607
93MP0003045_fibrosis0.80854561
94MP0003948_abnormal_gas_homeostasis0.77030249
95MP0003195_calcinosis0.77014708
96MP0009643_abnormal_urine_homeostasis0.76754594
97MP0005584_abnormal_enzyme/coenzyme_acti0.76346879
98MP0000230_abnormal_systemic_arterial0.75277294
99MP0004883_abnormal_blood_vessel0.74019296
100MP0001873_stomach_inflammation0.73113355
101MP0002972_abnormal_cardiac_muscle0.72449936
102MP0005666_abnormal_adipose_tissue0.72222976
103MP0003943_abnormal_hepatobiliary_system0.70931274
104MP0001661_extended_life_span0.69419081
105MP0005647_abnormal_sex_gland0.69128466
106MP0000759_abnormal_skeletal_muscle0.69100802
107* MP0000266_abnormal_heart_morphology0.68843461
108MP0004233_abnormal_muscle_weight0.68663602
109MP0009053_abnormal_anal_canal0.68547503
110* MP0001672_abnormal_embryogenesis/_devel0.67835306
111* MP0005380_embryogenesis_phenotype0.67835306
112MP0003868_abnormal_feces_composition0.65982921
113MP0005023_abnormal_wound_healing0.64900621
114MP0002106_abnormal_muscle_physiology0.64182478
115MP0008469_abnormal_protein_level0.63805972
116MP0005623_abnormal_meninges_morphology0.63686114
117MP0005376_homeostasis/metabolism_phenot0.63434602
118MP0000467_abnormal_esophagus_morphology0.62063696
119MP0001730_embryonic_growth_arrest0.62032882
120MP0005620_abnormal_muscle_contractility0.61298322
121MP0001533_abnormal_skeleton_physiology0.61073090
122MP0005503_abnormal_tendon_morphology0.59897826
123MP0005369_muscle_phenotype0.58590896
124MP0003385_abnormal_body_wall0.58357410
125MP0003091_abnormal_cell_migration0.58269603
126MP0003119_abnormal_digestive_system0.56788305
127MP0000462_abnormal_digestive_system0.55036542
128MP0005084_abnormal_gallbladder_morpholo0.54400792
129MP0005187_abnormal_penis_morphology0.53676995
130* MP0000013_abnormal_adipose_tissue0.53345873
131MP0004087_abnormal_muscle_fiber0.53183147
132MP0008874_decreased_physiological_sensi0.53118421
133MP0004858_abnormal_nervous_system0.52944618
134MP0004185_abnormal_adipocyte_glucose0.52901133
135MP0001293_anophthalmia0.52871567
136MP0005636_abnormal_mineral_homeostasis0.52042505
137MP0009765_abnormal_xenobiotic_induced0.51999138
138MP0002133_abnormal_respiratory_system0.51776932
139MP0005388_respiratory_system_phenotype0.51776932
140MP0002084_abnormal_developmental_patter0.51611922
141MP0002896_abnormal_bone_mineralization0.51290902
142MP0003186_abnormal_redox_activity0.51234691
143MP0005275_abnormal_skin_tensile0.50951971
144MP0002234_abnormal_pharynx_morphology0.50776800
145MP0009115_abnormal_fat_cell0.50659870
146MP0002796_impaired_skin_barrier0.49804974

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.30585214
2Skull defect (HP:0001362)5.11986234
3Prolonged partial thromboplastin time (HP:0003645)5.10485542
4Intrahepatic cholestasis (HP:0001406)4.88057443
5Joint hemorrhage (HP:0005261)4.51591445
6Polycythemia (HP:0001901)4.31726124
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29394245
8Broad metatarsal (HP:0001783)4.29247183
9Esophageal varix (HP:0002040)4.26339231
10Lymphangioma (HP:0100764)4.21800472
11Xanthomatosis (HP:0000991)4.21069063
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.19233531
13* Nonimmune hydrops fetalis (HP:0001790)4.12781787
14Hypoalphalipoproteinemia (HP:0003233)4.09055318
15Short hallux (HP:0010109)3.88264847
16Wrist flexion contracture (HP:0001239)3.83127495
17Abnormality of the intrinsic pathway (HP:0010989)3.82602867
18Hypolipoproteinemia (HP:0010981)3.68861399
19Hypobetalipoproteinemia (HP:0003563)3.66855518
20Hyperlipoproteinemia (HP:0010980)3.65479608
21Aplasia/Hypoplasia of the hallux (HP:0008362)3.60349957
22Increased variability in muscle fiber diameter (HP:0003557)3.57490322
23Spontaneous hematomas (HP:0007420)3.51693435
24Ventricular tachycardia (HP:0004756)3.42042232
25Adactyly (HP:0009776)3.40764058
26Complement deficiency (HP:0004431)3.37432648
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.33505961
28Hypoglycemic coma (HP:0001325)3.32396915
29Abnormality of skeletal muscle fiber size (HP:0012084)3.22512617
30Abnormality of the common coagulation pathway (HP:0010990)3.18658874
31Vascular calcification (HP:0004934)3.15717211
32Porencephaly (HP:0002132)3.14125438
33Hematochezia (HP:0002573)3.13117124
34Cardiovascular calcification (HP:0011915)3.12001467
35Spinal rigidity (HP:0003306)3.11322696
36Hyperammonemia (HP:0001987)3.09978332
37Hypoplastic ischia (HP:0003175)3.08582959
38Absent hand (HP:0004050)3.03984053
39Abnormality of the hepatic vasculature (HP:0006707)2.99777582
40Hypoplasia of the iris (HP:0007676)2.99372215
41Abnormality of the ischium (HP:0003174)2.94801371
42Conjunctival telangiectasia (HP:0000524)2.90691498
43Ketosis (HP:0001946)2.88199397
44Cerebral hemorrhage (HP:0001342)2.86241116
45Hemorrhage of the eye (HP:0011885)2.85433688
46Difficulty climbing stairs (HP:0003551)2.85260332
47High pitched voice (HP:0001620)2.79129113
48Congenital, generalized hypertrichosis (HP:0004540)2.73549032
49Myotonia (HP:0002486)2.69756326
50Difficulty running (HP:0009046)2.63224206
51Cerebral aneurysm (HP:0004944)2.61421808
52Epidermoid cyst (HP:0200040)2.59183537
53Absent eyelashes (HP:0000561)2.58952510
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56093990
55Aortic aneurysm (HP:0004942)2.55833103
56Hepatocellular carcinoma (HP:0001402)2.55312465
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53587911
58Cardiomegaly (HP:0001640)2.52957532
59Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.52629090
60Fat malabsorption (HP:0002630)2.51259367
61Myocardial infarction (HP:0001658)2.47697736
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46981277
63Short 4th metacarpal (HP:0010044)2.46981277
64Ectopia lentis (HP:0001083)2.44483673
65Abnormality of complement system (HP:0005339)2.43742054
66Abnormality of the 4th metacarpal (HP:0010012)2.43194531
67Shallow orbits (HP:0000586)2.42991588
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.42420654
69Right ventricular cardiomyopathy (HP:0011663)2.41587581
70Thrombophlebitis (HP:0004418)2.40229313
71Protrusio acetabuli (HP:0003179)2.39055790
72Abnormality of the nasal mucosa (HP:0000433)2.38124799
73Disproportionate tall stature (HP:0001519)2.37871238
74Ketoacidosis (HP:0001993)2.35616400
75Pulmonary hypertension (HP:0002092)2.33154976
76Hypercholesterolemia (HP:0003124)2.33026335
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.32692096
78Hyperglycinemia (HP:0002154)2.31866975
79Premature rupture of membranes (HP:0001788)2.30580237
80Abnormality of the peritoneum (HP:0002585)2.30214132
81Distal lower limb amyotrophy (HP:0008944)2.29831300
82Overgrowth (HP:0001548)2.29009196
83Venous insufficiency (HP:0005293)2.28354906
84Prominent supraorbital ridges (HP:0000336)2.28223073
85Visceral angiomatosis (HP:0100761)2.26645934
86Abnormality of fatty-acid metabolism (HP:0004359)2.26550897
87Hyperglycinuria (HP:0003108)2.24566815
88Hip contracture (HP:0003273)2.23406167
89Stroke (HP:0001297)2.23004042
90Increased connective tissue (HP:0009025)2.22972352
91Long eyelashes (HP:0000527)2.22895263
92Large for gestational age (HP:0001520)2.22505887
93Abnormality of glycine metabolism (HP:0010895)2.21382162
94Abnormality of serine family amino acid metabolism (HP:0010894)2.21382162
95Abnormality of the aortic arch (HP:0012303)2.21207191
96Vitreoretinal degeneration (HP:0000655)2.19597298
97Abnormality of the anterior chamber (HP:0000593)2.19500418
98Tetraparesis (HP:0002273)2.18718580
99Absent toe (HP:0010760)2.17828615
100Hyporeflexia of lower limbs (HP:0002600)2.17633901
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16695763
102Venous abnormality (HP:0002624)2.16596269
103Skin nodule (HP:0200036)2.16484749
104Aneurysm (HP:0002617)2.15639002
105Hemangiomatosis (HP:0007461)2.15336902
106* Capillary hemangiomas (HP:0005306)2.15011129
107Abnormal vertebral ossification (HP:0100569)2.13186966
108Occipital encephalocele (HP:0002085)2.12827641
109Hypoglycemic seizures (HP:0002173)2.12454446
110Preaxial foot polydactyly (HP:0001841)2.11975738
111Mitral stenosis (HP:0001718)2.11975347
112Pulmonary embolism (HP:0002204)2.11689169
113Mitral valve prolapse (HP:0001634)2.09987410
114Abnormality of methionine metabolism (HP:0010901)2.09236596
115Pulmonary artery stenosis (HP:0004415)2.09050566
116Abnormality of purine metabolism (HP:0004352)2.08876749
117Portal hypertension (HP:0001409)2.08308911
118Delayed CNS myelination (HP:0002188)2.07239843
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07172886
120Abnormality of the fingertips (HP:0001211)2.04492772
121Muscle fiber splitting (HP:0003555)2.03787320
122Hyperbilirubinemia (HP:0002904)2.03000985
123Absent eyebrow (HP:0002223)2.02444558
124Exotropia (HP:0000577)2.02345135
125Interstitial pulmonary disease (HP:0006530)2.01972950
126Dicarboxylic aciduria (HP:0003215)2.00338165
127Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00338165
128Neonatal death (HP:0003811)1.99474556
129Amyloidosis (HP:0011034)1.99382209
130Spastic diplegia (HP:0001264)1.98976059
131Hyperglycemia (HP:0003074)1.98436360
132Atrioventricular block (HP:0001678)1.98291700
133Hemiplegia (HP:0002301)1.97947986
134Abnormality of nucleobase metabolism (HP:0010932)1.96156898
135Thin ribs (HP:0000883)1.96147253
136Hyperinsulinemic hypoglycemia (HP:0000825)1.96097632
137Neoplasm of the heart (HP:0100544)1.94570706
138Areflexia of lower limbs (HP:0002522)1.93367565
139Conjugated hyperbilirubinemia (HP:0002908)1.93116759
140Stridor (HP:0010307)1.90390921
141Cervical subluxation (HP:0003308)1.88986820
142Chondrocalcinosis (HP:0000934)1.88714792
143Short clavicles (HP:0000894)1.87807212
144Spontaneous abortion (HP:0005268)1.87236790
145Sudden death (HP:0001699)1.87218664
146Anterior segment dysgenesis (HP:0007700)1.86453405
147Muscle fibrillation (HP:0010546)1.85932044
148Cavernous hemangioma (HP:0001048)1.85052394
149Menorrhagia (HP:0000132)1.83874077
150Cutis marmorata (HP:0000965)1.83749446
151Short palpebral fissure (HP:0012745)1.82938078
152Atrial fibrillation (HP:0005110)1.82311754
153Limited hip movement (HP:0008800)1.78646133
154Flexion contracture of toe (HP:0005830)1.78260096
155Joint contractures involving the joints of the feet (HP:0100492)1.78260096
156Round ear (HP:0100830)1.77190095
157Germ cell neoplasia (HP:0100728)1.76995307
158Lumbar hyperlordosis (HP:0002938)1.74499761
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.74400234
160Aortic valve stenosis (HP:0001650)1.73999130
161J-shaped sella turcica (HP:0002680)1.73017865
162Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72422035
163Protruding ear (HP:0000411)1.70808503
164Heart block (HP:0012722)1.69993356
165Asymmetric septal hypertrophy (HP:0001670)1.69232164
166Abnormal atrioventricular conduction (HP:0005150)1.68735791
167Obstructive sleep apnea (HP:0002870)1.68607046
168Rectal prolapse (HP:0002035)1.66077023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.82896186
2* KDR8.29564353
3TGFBR23.80809639
4ERN13.16884583
5TGFBR12.78410914
6FES2.59718946
7EEF2K2.19560608
8RIPK12.19290790
9BCKDK1.74818914
10PKN21.74241855
11FGFR41.70548892
12PTK61.64431759
13JAK11.54693318
14SIK11.50551580
15PTK2B1.50512486
16SMG11.49802283
17EPHB21.49328634
18EPHB11.46274842
19GRK11.40476323
20FER1.28173737
21MARK21.20818963
22TTN1.20532250
23CAMK41.18086115
24JAK31.17044221
25TRIB31.16625384
26INSRR1.16573082
27FLT31.12554599
28PRKD31.09623780
29MAP2K31.06256403
30RPS6KA21.03462113
31JAK21.03227819
32PTK21.02981361
33MAPK120.95661074
34MAP3K60.94158066
35MAP3K130.93258050
36MET0.91155397
37PDGFRA0.90525002
38DAPK20.88815193
39MYLK0.83732814
40MAP3K110.80931822
41PAK40.80397008
42TNK20.80359986
43SCYL20.78522643
44LATS10.77307974
45PDK20.74113920
46PRKG20.70331483
47EPHA20.70047436
48RPS6KC10.68898111
49RPS6KL10.68898111
50CDK120.67146060
51RET0.65258139
52RPS6KA60.64531093
53TYRO30.63322640
54TYK20.62758167
55MAP2K10.62139077
56MAP3K30.62056383
57MAPK150.61906684
58PRKD20.58213751
59CDC42BPA0.57965410
60MAP3K100.57216798
61ERBB40.54985782
62CSK0.54902727
63LATS20.52330922
64TEC0.51527377
65MAPK70.51410584
66HIPK20.50903872
67PRKD10.50824167
68IGF1R0.49513921
69PRKAA20.47326398
70CSNK1A1L0.47215198
71PRKCH0.46503854
72AKT20.46378477
73LRRK20.46180044
74CSNK1G10.45936728
75TBK10.45522264
76MAP3K10.45332389
77MAP2K60.45236993
78GSK3A0.45191418
79EGFR0.45114902
80CDK90.45105257
81MAP2K20.43845990
82NEK90.43578944
83CSNK1G30.42719723
84TRPM70.42634839
85FGFR20.41843955
86ITK0.41592777
87HCK0.41360444
88DMPK0.41205268
89FGFR30.41112268
90DAPK30.40835551
91EPHA30.40797245
92PKN10.40482761
93MAP2K40.38978642
94LMTK20.37306978
95MUSK0.35346355
96AKT30.35231517
97STK100.33962870
98MAP3K70.33847442
99PAK20.32242622
100PAK30.30895999
101FGFR10.27246795
102GRK50.27135214
103MAPK110.27082279
104CDK60.27049637
105CAMK1D0.26783490
106ABL20.26229475
107* SRC0.26073670
108MTOR0.25622391
109MAP4K10.23683185
110CDK80.23485950
111CDK30.23215327
112MAPK40.23200038
113OBSCN0.22702936
114ILK0.22232307
115MST1R0.21430719
116RPS6KA50.20548299
117CAMK1G0.20285728
118TESK10.20157163
119ERBB20.20134185
120PDGFRB0.19930015
121CDK70.19194281
122PRKAA10.18949073
123PRPF4B0.17629405
124NME10.17474112
125NTRK10.17259734
126INSR0.16990415
127BLK0.16988132
128IRAK30.16523095
129PDPK10.16134295
130DYRK1B0.15506739
131STK110.15435301
132PIK3CG0.14458378
133TAOK30.14228848
134BMX0.14198524
135PRKACG0.12480656
136MAP3K140.12351787
137ROCK10.11646440
138PHKG20.10851087
139PHKG10.10851087
140MAPK10.10282297
141ZAP700.09466714
142PIK3CA0.09298983
143ICK0.08709690

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96283247
2Complement and coagulation cascades_Homo sapiens_hsa046103.87640806
3Nitrogen metabolism_Homo sapiens_hsa009103.52600425
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44077359
5Arginine biosynthesis_Homo sapiens_hsa002203.23712802
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86814656
7Fatty acid degradation_Homo sapiens_hsa000712.60371990
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42170224
9Tryptophan metabolism_Homo sapiens_hsa003802.39623535
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28880749
11PPAR signaling pathway_Homo sapiens_hsa033202.24433273
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19628415
13Bile secretion_Homo sapiens_hsa049761.92503272
14Staphylococcus aureus infection_Homo sapiens_hsa051501.90147479
15Propanoate metabolism_Homo sapiens_hsa006401.89214522
16Fatty acid metabolism_Homo sapiens_hsa012121.87655904
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85416217
18Butanoate metabolism_Homo sapiens_hsa006501.83320166
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69917994
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69705034
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66541784
22Peroxisome_Homo sapiens_hsa041461.63255579
23Axon guidance_Homo sapiens_hsa043601.62114980
24ABC transporters_Homo sapiens_hsa020101.61871276
25Caffeine metabolism_Homo sapiens_hsa002321.60306391
26Other glycan degradation_Homo sapiens_hsa005111.55218017
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.53664726
28Chemical carcinogenesis_Homo sapiens_hsa052041.50346325
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.48552467
30Malaria_Homo sapiens_hsa051441.46140761
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.41351308
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39319740
33beta-Alanine metabolism_Homo sapiens_hsa004101.38998259
34Histidine metabolism_Homo sapiens_hsa003401.35142038
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32538920
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25006919
37Phenylalanine metabolism_Homo sapiens_hsa003601.24888719
38Chronic myeloid leukemia_Homo sapiens_hsa052201.24410852
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.24284060
40African trypanosomiasis_Homo sapiens_hsa051431.24280304
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22948885
42Tight junction_Homo sapiens_hsa045301.22354052
43Bladder cancer_Homo sapiens_hsa052191.19282578
44Retinol metabolism_Homo sapiens_hsa008301.18961243
45Starch and sucrose metabolism_Homo sapiens_hsa005001.15557804
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14960687
47Fat digestion and absorption_Homo sapiens_hsa049751.14779425
48Pyruvate metabolism_Homo sapiens_hsa006201.14367822
49Vitamin digestion and absorption_Homo sapiens_hsa049771.13207690
50Selenocompound metabolism_Homo sapiens_hsa004501.10776096
51* Ras signaling pathway_Homo sapiens_hsa040141.09526265
52HIF-1 signaling pathway_Homo sapiens_hsa040661.09454072
53Choline metabolism in cancer_Homo sapiens_hsa052311.08753950
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06821129
55Tyrosine metabolism_Homo sapiens_hsa003501.04426897
56Carbon metabolism_Homo sapiens_hsa012001.04115252
57Pathways in cancer_Homo sapiens_hsa052001.02525242
58Fatty acid elongation_Homo sapiens_hsa000621.00512302
59Pancreatic cancer_Homo sapiens_hsa052120.99714290
60MicroRNAs in cancer_Homo sapiens_hsa052060.98804048
61Protein digestion and absorption_Homo sapiens_hsa049740.96594294
62Lysine degradation_Homo sapiens_hsa003100.95528517
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95505644
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93700991
65Basal cell carcinoma_Homo sapiens_hsa052170.92867626
66Glioma_Homo sapiens_hsa052140.92694323
67Arginine and proline metabolism_Homo sapiens_hsa003300.91453687
68TGF-beta signaling pathway_Homo sapiens_hsa043500.91399963
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90653479
70Biosynthesis of amino acids_Homo sapiens_hsa012300.88487252
71GnRH signaling pathway_Homo sapiens_hsa049120.87423242
72Insulin signaling pathway_Homo sapiens_hsa049100.83695568
73Renal cell carcinoma_Homo sapiens_hsa052110.82538714
74Sulfur metabolism_Homo sapiens_hsa009200.82319517
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80919679
76ECM-receptor interaction_Homo sapiens_hsa045120.78540769
77Inositol phosphate metabolism_Homo sapiens_hsa005620.73288690
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72483484
79Melanogenesis_Homo sapiens_hsa049160.71939488
80Insulin resistance_Homo sapiens_hsa049310.71157051
81Acute myeloid leukemia_Homo sapiens_hsa052210.70458111
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.67668622
83Estrogen signaling pathway_Homo sapiens_hsa049150.66652420
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66651014
85Pertussis_Homo sapiens_hsa051330.65624857
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64400474
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.63692382
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61335746
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.61333975
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61203485
91Prostate cancer_Homo sapiens_hsa052150.60610110
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.59841489
93Endocytosis_Homo sapiens_hsa041440.58492306
94* Focal adhesion_Homo sapiens_hsa045100.58196599
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.58161063
96Gap junction_Homo sapiens_hsa045400.57745014
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56918899
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.56187177
99Systemic lupus erythematosus_Homo sapiens_hsa053220.55911524
100Glycerolipid metabolism_Homo sapiens_hsa005610.55573490
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55571772
102mTOR signaling pathway_Homo sapiens_hsa041500.55518101
103Hippo signaling pathway_Homo sapiens_hsa043900.55487436
104Dilated cardiomyopathy_Homo sapiens_hsa054140.54548563
105Folate biosynthesis_Homo sapiens_hsa007900.54352860
106Adherens junction_Homo sapiens_hsa045200.53537474
107Base excision repair_Homo sapiens_hsa034100.53037781
108FoxO signaling pathway_Homo sapiens_hsa040680.50128557
109Melanoma_Homo sapiens_hsa052180.49316175
110MAPK signaling pathway_Homo sapiens_hsa040100.47599751
111Renin-angiotensin system_Homo sapiens_hsa046140.46557448
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45012038
113Colorectal cancer_Homo sapiens_hsa052100.41779623
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41204960
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41068554
116Alcoholism_Homo sapiens_hsa050340.40934470
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40355436
118Hedgehog signaling pathway_Homo sapiens_hsa043400.39242908
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38639914
120HTLV-I infection_Homo sapiens_hsa051660.38618403
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.37999218
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37646180
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.37436613
124* Rap1 signaling pathway_Homo sapiens_hsa040150.36876519
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34497784
126Amoebiasis_Homo sapiens_hsa051460.33343009
127Ovarian steroidogenesis_Homo sapiens_hsa049130.33313183
128Prion diseases_Homo sapiens_hsa050200.32769754
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32555105
130Steroid biosynthesis_Homo sapiens_hsa001000.32050832
131Proteoglycans in cancer_Homo sapiens_hsa052050.31752528
132Fatty acid biosynthesis_Homo sapiens_hsa000610.31064602
133TNF signaling pathway_Homo sapiens_hsa046680.29849475
134Pentose phosphate pathway_Homo sapiens_hsa000300.27029946
135* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26416080
136Sulfur relay system_Homo sapiens_hsa041220.25411452
137Notch signaling pathway_Homo sapiens_hsa043300.24887274
138Galactose metabolism_Homo sapiens_hsa000520.22243655
139Glucagon signaling pathway_Homo sapiens_hsa049220.22016468
140Glutathione metabolism_Homo sapiens_hsa004800.20645227
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20557010
142Small cell lung cancer_Homo sapiens_hsa052220.20317083
143Dorso-ventral axis formation_Homo sapiens_hsa043200.19707364
144AMPK signaling pathway_Homo sapiens_hsa041520.18349297
145Platelet activation_Homo sapiens_hsa046110.16209448
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15945248
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.12905461
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12499636
149Metabolic pathways_Homo sapiens_hsa011000.12311121
150VEGF signaling pathway_Homo sapiens_hsa043700.11017274
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10782944
152Viral myocarditis_Homo sapiens_hsa054160.09093209

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