FLRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphorelay signal transduction system (GO:0000160)7.35626111
2adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.08767084
3detection of calcium ion (GO:0005513)6.90844124
4modulation by virus of host process (GO:0019054)5.96177430
5sensory perception of smell (GO:0007608)5.43102748
6cellular response to prostaglandin stimulus (GO:0071379)5.33375843
7gamma-aminobutyric acid transport (GO:0015812)5.19905162
8locomotory exploration behavior (GO:0035641)5.10969678
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.98293204
10dendritic spine morphogenesis (GO:0060997)4.97114573
11neuron cell-cell adhesion (GO:0007158)4.92545932
12G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.86248372
13sensory perception of chemical stimulus (GO:0007606)4.75959577
14neuronal action potential (GO:0019228)4.74249105
15regulation of chromatin binding (GO:0035561)4.46934379
16protein localization to cilium (GO:0061512)4.46906546
17synaptic vesicle maturation (GO:0016188)4.43172322
18modulation by symbiont of host cellular process (GO:0044068)4.42477352
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.36288316
20protein localization to synapse (GO:0035418)4.35964816
21cellular response to glucagon stimulus (GO:0071377)4.33868841
22regulation of cilium movement (GO:0003352)4.27004859
23auditory behavior (GO:0031223)4.25142128
24sensory perception of taste (GO:0050909)4.22041090
25exploration behavior (GO:0035640)4.16768622
26synaptic transmission, glutamatergic (GO:0035249)4.11015502
27nucleobase catabolic process (GO:0046113)4.08685748
28cellular response to virus (GO:0098586)4.05895915
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.03670790
30positive regulation of synapse maturation (GO:0090129)4.03426251
31intraciliary transport (GO:0042073)4.00463559
32glutamate receptor signaling pathway (GO:0007215)3.91517168
33axoneme assembly (GO:0035082)3.80384184
34synapse assembly (GO:0007416)3.80273487
35microtubule bundle formation (GO:0001578)3.77860000
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74476275
37positive regulation of synapse assembly (GO:0051965)3.73352107
38cerebellar granule cell differentiation (GO:0021707)3.71789490
39establishment of mitochondrion localization (GO:0051654)3.70102276
40response to prostaglandin E (GO:0034695)3.69553025
41protein polyglutamylation (GO:0018095)3.68901226
42neurotransmitter secretion (GO:0007269)3.65663769
43response to auditory stimulus (GO:0010996)3.59326062
44protein insertion into membrane (GO:0051205)3.59043291
45axonal fasciculation (GO:0007413)3.57043984
46regulation of synapse maturation (GO:0090128)3.56408838
47axon ensheathment in central nervous system (GO:0032291)3.55787545
48central nervous system myelination (GO:0022010)3.55787545
49neuron-neuron synaptic transmission (GO:0007270)3.55507478
50positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51178459
51mechanosensory behavior (GO:0007638)3.50523335
52presynaptic membrane assembly (GO:0097105)3.48783628
53startle response (GO:0001964)3.46873291
54iron-sulfur cluster assembly (GO:0016226)3.45623614
55metallo-sulfur cluster assembly (GO:0031163)3.45623614
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43574919
57neurofilament cytoskeleton organization (GO:0060052)3.39312455
58regulation of synaptic vesicle exocytosis (GO:2000300)3.36974101
59postsynaptic membrane organization (GO:0001941)3.35951770
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35504459
61transmission of nerve impulse (GO:0019226)3.34070600
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34064864
63cellular response to catecholamine stimulus (GO:0071870)3.33976984
64cellular response to monoamine stimulus (GO:0071868)3.33976984
65neuronal action potential propagation (GO:0019227)3.33833770
66negative regulation of catenin import into nucleus (GO:0035414)3.31058895
67neuron recognition (GO:0008038)3.30093016
68negative regulation of execution phase of apoptosis (GO:1900118)3.29530585
69cell migration in hindbrain (GO:0021535)3.28578589
70dopamine receptor signaling pathway (GO:0007212)3.26055603
71dendritic spine organization (GO:0097061)3.25600597
72central nervous system projection neuron axonogenesis (GO:0021952)3.25562362
73spinal cord development (GO:0021510)3.24180204
74response to catecholamine (GO:0071869)3.22317384
75response to monoamine (GO:0071867)3.22317384
76regulation of protein targeting to membrane (GO:0090313)3.21637915
77behavioral response to cocaine (GO:0048148)3.21448365
78vocalization behavior (GO:0071625)3.21235684
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21166848
80synapse organization (GO:0050808)3.20862670
81L-amino acid import (GO:0043092)3.18371210
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17961088
83ER overload response (GO:0006983)3.16551645
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.16235602
85adult walking behavior (GO:0007628)3.16143462
86ADP metabolic process (GO:0046031)3.14046111
87response to glucagon (GO:0033762)3.11674658
88dendrite morphogenesis (GO:0048813)3.11239551
89cilium movement (GO:0003341)3.11159300
90negative regulation of neurotransmitter transport (GO:0051589)3.11056857
91negative regulation of microtubule polymerization (GO:0031115)3.11029027
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10665168
93calcium-mediated signaling using intracellular calcium source (GO:0035584)3.10256321
94regulation of synapse assembly (GO:0051963)3.09616057
95neuromuscular synaptic transmission (GO:0007274)3.05946249
96response to prostaglandin (GO:0034694)3.05042901
97neurotransmitter-gated ion channel clustering (GO:0072578)3.04952693
98negative regulation of neurotransmitter secretion (GO:0046929)3.04489427
99presynaptic membrane organization (GO:0097090)3.03212525
100cilium morphogenesis (GO:0060271)3.03054663
101amino acid import (GO:0043090)3.01453289
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01384646
103regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00611345
104lactate metabolic process (GO:0006089)3.00351237
105snRNA transcription (GO:0009301)3.00115107
106glutamate secretion (GO:0014047)2.98207424
107regulation of hexokinase activity (GO:1903299)2.96979242
108regulation of glucokinase activity (GO:0033131)2.96979242
109nonmotile primary cilium assembly (GO:0035058)2.96516275
110positive regulation of neurotransmitter secretion (GO:0001956)2.95369325
111atrial cardiac muscle cell action potential (GO:0086014)2.94633950
112ganglion development (GO:0061548)2.91846960
113regulation of synaptic vesicle transport (GO:1902803)2.90683713
114negative regulation of axon extension (GO:0030517)2.90444300
115synaptic vesicle exocytosis (GO:0016079)2.89735768
116action potential (GO:0001508)2.89706622
117pyrimidine nucleobase catabolic process (GO:0006208)2.88858317
118regulation of synapse organization (GO:0050807)2.88851104
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88715488
120mating behavior (GO:0007617)2.88709325
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88523404
122positive regulation of action potential (GO:0045760)2.88418107
123regulation of synapse structural plasticity (GO:0051823)2.85556170
124regulation of respiratory system process (GO:0044065)2.85487605
125calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85202930
126righting reflex (GO:0060013)2.85173335
127negative regulation of axonogenesis (GO:0050771)2.84279053
128female mating behavior (GO:0060180)2.83853530
129neuronal ion channel clustering (GO:0045161)2.83780752
130mitochondrion transport along microtubule (GO:0047497)2.83772573
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83772573
132neurotransmitter transport (GO:0006836)2.83693124
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83615505
134regulation of neuronal synaptic plasticity (GO:0048168)2.83015222
135long-term memory (GO:0007616)2.82447551
136venous blood vessel morphogenesis (GO:0048845)2.79938494
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79893750
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77548887
139regulation of neurotransmitter levels (GO:0001505)2.77416394
140positive regulation of vascular permeability (GO:0043117)2.76429203
141positive regulation of neurotransmitter transport (GO:0051590)2.76001471
142layer formation in cerebral cortex (GO:0021819)2.75949856
143brain morphogenesis (GO:0048854)2.75390777
144regulation of NFAT protein import into nucleus (GO:0051532)2.74689962
145regulation of female receptivity (GO:0045924)2.74594932
146positive regulation of neurological system process (GO:0031646)2.73669492
147positive regulation of dendritic spine development (GO:0060999)2.72867700
148negative regulation of dendrite morphogenesis (GO:0050774)2.72554465
149cellular copper ion homeostasis (GO:0006878)2.72251165
150regulation of neurotransmitter secretion (GO:0046928)2.71899152
151membrane depolarization during action potential (GO:0086010)2.71692182
152regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70371543
153positive regulation of membrane potential (GO:0045838)2.69758352
154regulation of glutamate receptor signaling pathway (GO:1900449)2.69741694
155neuromuscular process controlling balance (GO:0050885)2.69436582
156adult behavior (GO:0030534)2.68951348
157membrane hyperpolarization (GO:0060081)2.68845738
158cerebral cortex radially oriented cell migration (GO:0021799)2.68396260
159intraspecies interaction between organisms (GO:0051703)2.67990653
160social behavior (GO:0035176)2.67990653
161behavioral response to nicotine (GO:0035095)2.67979187
162regulation of synaptic transmission, GABAergic (GO:0032228)2.67304091
163central nervous system neuron axonogenesis (GO:0021955)2.66435641
164negative regulation of oligodendrocyte differentiation (GO:0048715)2.66358163
165membrane depolarization (GO:0051899)2.64600148
166regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64101343
167positive regulation of potassium ion transmembrane transport (GO:1901381)2.62789707
168negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.62661811
169inositol phosphate catabolic process (GO:0071545)2.59160872
170cilium assembly (GO:0042384)2.57862371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.12070830
2GBX2_23144817_ChIP-Seq_PC3_Human3.78275729
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89195849
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79140907
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69779869
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55302129
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51195643
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35150490
9TAF15_26573619_Chip-Seq_HEK293_Human2.30308235
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19280504
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18795929
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18795929
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.11669842
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10174969
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07082856
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.06014405
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05036789
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03592849
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02918483
20AR_21572438_ChIP-Seq_LNCaP_Human2.00027693
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92300473
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.90149011
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88211777
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84362158
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83440375
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83268147
27ZNF274_21170338_ChIP-Seq_K562_Hela1.83001938
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82083197
29IGF1R_20145208_ChIP-Seq_DFB_Human1.78621154
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.78277489
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72274996
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.70883387
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69281925
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67792783
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67604337
36SMAD4_21799915_ChIP-Seq_A2780_Human1.66669903
37AHR_22903824_ChIP-Seq_MCF-7_Human1.66436964
38P300_19829295_ChIP-Seq_ESCs_Human1.66014104
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65132541
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62797093
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61883955
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61449861
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60903730
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60363774
45* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58298065
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57833397
47VDR_22108803_ChIP-Seq_LS180_Human1.53801861
48* DROSHA_22980978_ChIP-Seq_HELA_Human1.50029046
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49111849
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.47980323
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46964832
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45270825
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44337749
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37406065
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36179553
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.33872800
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33055616
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33055616
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31933699
60RNF2_27304074_Chip-Seq_NSC_Mouse1.31932336
61TP53_18474530_ChIP-ChIP_U2OS_Human1.31692426
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.31515464
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29763649
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29066219
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28146050
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.28117810
67* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27630432
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26205684
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.25044911
70FUS_26573619_Chip-Seq_HEK293_Human1.24752479
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24038338
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22660558
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21503269
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20744154
75STAT3_23295773_ChIP-Seq_U87_Human1.19041345
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.18405088
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17730280
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.16775517
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16571117
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15287325
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14085593
82ER_23166858_ChIP-Seq_MCF-7_Human1.12862075
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12776265
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11026288
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10254857
86TCF4_23295773_ChIP-Seq_U87_Human1.09740734
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07706481
88JUN_21703547_ChIP-Seq_K562_Human1.07478536
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07452518
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.06698080
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.06446863
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.05234161
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04975722
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04463084
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00943700
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00783817
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.00581263
98* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00160574
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99760976
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98878476
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98430519
102AR_19668381_ChIP-Seq_PC3_Human0.97426993
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97300691
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.96118223
105P300_18555785_Chip-Seq_ESCs_Mouse0.95903706
106SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95462167
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94885424
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94769407
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94458184
110CBP_20019798_ChIP-Seq_JUKART_Human0.94458184
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94119524
112P53_22387025_ChIP-Seq_ESCs_Mouse0.93740539
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92430209
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.92413049
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.92266717
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.92034040
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92018942
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90797268
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90259825
120* SOX9_26525672_Chip-Seq_HEART_Mouse0.89898638
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.89531121
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89324610
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88967870
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88683320
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.88505203
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87182673
127* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86858157
128* AR_25329375_ChIP-Seq_VCAP_Human0.86758596
129* KDM2B_26808549_Chip-Seq_REH_Human0.86099537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.55922382
2MP0008789_abnormal_olfactory_epithelium4.02100958
3MP0005645_abnormal_hypothalamus_physiol3.87607621
4MP0005394_taste/olfaction_phenotype3.72174059
5MP0005499_abnormal_olfactory_system3.72174059
6MP0004858_abnormal_nervous_system3.18160131
7MP0003878_abnormal_ear_physiology3.12855039
8MP0005377_hearing/vestibular/ear_phenot3.12855039
9MP0004859_abnormal_synaptic_plasticity2.94466543
10MP0004270_analgesia2.92804993
11MP0005171_absent_coat_pigmentation2.86825859
12MP0000372_irregular_coat_pigmentation2.86598475
13MP0003635_abnormal_synaptic_transmissio2.42334074
14MP0005646_abnormal_pituitary_gland2.37379153
15MP0001485_abnormal_pinna_reflex2.32326803
16MP0006276_abnormal_autonomic_nervous2.29050131
17MP0003880_abnormal_central_pattern2.27661529
18MP0002160_abnormal_reproductive_system2.24015843
19MP0002063_abnormal_learning/memory/cond2.08706544
20MP0002734_abnormal_mechanical_nocicepti2.06573177
21MP0003122_maternal_imprinting2.05125616
22MP0002184_abnormal_innervation1.96635739
23MP0002572_abnormal_emotion/affect_behav1.96303041
24MP0002064_seizures1.91516692
25MP0009745_abnormal_behavioral_response1.91397266
26MP0000778_abnormal_nervous_system1.89945663
27MP0002272_abnormal_nervous_system1.86653080
28MP0000015_abnormal_ear_pigmentation1.86585546
29MP0001188_hyperpigmentation1.86079650
30MP0002557_abnormal_social/conspecific_i1.83444043
31MP0001486_abnormal_startle_reflex1.83365493
32MP0002938_white_spotting1.81357049
33MP0001968_abnormal_touch/_nociception1.59807765
34MP0009046_muscle_twitch1.58578325
35MP0004142_abnormal_muscle_tone1.57427602
36MP0004742_abnormal_vestibular_system1.50422180
37MP0004885_abnormal_endolymph1.50101088
38MP0002067_abnormal_sensory_capabilities1.48216256
39MP0002736_abnormal_nociception_after1.46834153
40MP0002822_catalepsy1.43979715
41MP0001905_abnormal_dopamine_level1.42979562
42MP0003136_yellow_coat_color1.41638781
43MP0001963_abnormal_hearing_physiology1.40821014
44MP0010386_abnormal_urinary_bladder1.40777346
45MP0001542_abnormal_bone_strength1.38786358
46MP0009780_abnormal_chondrocyte_physiolo1.38032608
47MP0002909_abnormal_adrenal_gland1.31717217
48MP0002735_abnormal_chemical_nociception1.31379018
49MP0000026_abnormal_inner_ear1.30156954
50MP0002882_abnormal_neuron_morphology1.27193469
51MP0001986_abnormal_taste_sensitivity1.25324902
52MP0005389_reproductive_system_phenotype1.23693037
53MP0000003_abnormal_adipose_tissue1.23664932
54MP0003879_abnormal_hair_cell1.23145892
55MP0005423_abnormal_somatic_nervous1.22273378
56MP0003121_genomic_imprinting1.20282104
57MP0005174_abnormal_tail_pigmentation1.17982004
58MP0001970_abnormal_pain_threshold1.15750082
59MP0004134_abnormal_chest_morphology1.09224213
60MP0001501_abnormal_sleep_pattern1.07638547
61MP0002752_abnormal_somatic_nervous1.07582893
62MP0002233_abnormal_nose_morphology1.07573598
63MP0002152_abnormal_brain_morphology1.06722974
64MP0000631_abnormal_neuroendocrine_gland1.06446624
65MP0004811_abnormal_neuron_physiology1.06296595
66MP0002102_abnormal_ear_morphology1.04779025
67MP0000049_abnormal_middle_ear1.03110769
68MP0003632_abnormal_nervous_system1.02120403
69MP0002249_abnormal_larynx_morphology0.99810375
70MP0004145_abnormal_muscle_electrophysio0.98032146
71MP0003787_abnormal_imprinting0.97946997
72MP0002751_abnormal_autonomic_nervous0.97538843
73MP0002229_neurodegeneration0.97141844
74MP0004924_abnormal_behavior0.94621516
75MP0005386_behavior/neurological_phenoty0.94621516
76MP0000569_abnormal_digit_pigmentation0.94396995
77MP0004133_heterotaxia0.94127447
78MP0006292_abnormal_olfactory_placode0.93855706
79MP0002095_abnormal_skin_pigmentation0.93539396
80MP0000920_abnormal_myelination0.93534036
81MP0003329_amyloid_beta_deposits0.93100722
82MP0006072_abnormal_retinal_apoptosis0.91029962
83MP0000013_abnormal_adipose_tissue0.90978096
84MP0002066_abnormal_motor_capabilities/c0.90377189
85MP0001440_abnormal_grooming_behavior0.89579771
86MP0005253_abnormal_eye_physiology0.88820806
87MP0003183_abnormal_peptide_metabolism0.88309935
88MP0002876_abnormal_thyroid_physiology0.87834616
89MP0002653_abnormal_ependyma_morphology0.87608435
90MP0001502_abnormal_circadian_rhythm0.86368238
91MP0008877_abnormal_DNA_methylation0.86174261
92MP0001299_abnormal_eye_distance/0.83942095
93MP0005551_abnormal_eye_electrophysiolog0.82412229
94MP0008569_lethality_at_weaning0.82135293
95MP0002127_abnormal_cardiovascular_syste0.81533729
96MP0002234_abnormal_pharynx_morphology0.80653114
97MP0003631_nervous_system_phenotype0.80132809
98MP0003119_abnormal_digestive_system0.80066958
99MP0001186_pigmentation_phenotype0.78619740
100MP0001177_atelectasis0.78390779
101MP0003861_abnormal_nervous_system0.77937934
102MP0002733_abnormal_thermal_nociception0.77306790
103MP0005187_abnormal_penis_morphology0.76145963
104MP0003941_abnormal_skin_development0.76092628
105MP0000955_abnormal_spinal_cord0.72497749
106MP0001943_abnormal_respiration0.71909900
107MP0003385_abnormal_body_wall0.71101243
108MP0002069_abnormal_eating/drinking_beha0.70227816
109MP0001529_abnormal_vocalization0.69552119
110MP0003806_abnormal_nucleotide_metabolis0.69485921
111MP0003283_abnormal_digestive_organ0.67949378
112MP0010770_preweaning_lethality0.66489141
113MP0002082_postnatal_lethality0.66489141
114MP0005367_renal/urinary_system_phenotyp0.66389897
115MP0000516_abnormal_urinary_system0.66389897
116MP0003890_abnormal_embryonic-extraembry0.66029291
117MP0003633_abnormal_nervous_system0.65983262
118MP0005195_abnormal_posterior_eye0.65846260
119MP0000534_abnormal_ureter_morphology0.65584163
120MP0000566_synostosis0.64986402
121MP0003634_abnormal_glial_cell0.60980333
122MP0002638_abnormal_pupillary_reflex0.60586594
123MP0000751_myopathy0.57827569
124MP0000538_abnormal_urinary_bladder0.57561259
125MP0003938_abnormal_ear_development0.52614541
126MP0004085_abnormal_heartbeat0.51709667
127MP0002837_dystrophic_cardiac_calcinosis0.50862392
128MP0002177_abnormal_outer_ear0.49457917
129MP0002081_perinatal_lethality0.48330710

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.74623061
2Febrile seizures (HP:0002373)5.53798208
3Atonic seizures (HP:0010819)4.97630345
4Gait imbalance (HP:0002141)4.53977411
5Congenital primary aphakia (HP:0007707)4.35913426
6Medial flaring of the eyebrow (HP:0010747)4.34131660
7Nephrogenic diabetes insipidus (HP:0009806)4.31086308
8Pancreatic fibrosis (HP:0100732)4.09511437
9Focal motor seizures (HP:0011153)4.06363018
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.02392740
11Abnormal respiratory motile cilium physiology (HP:0012261)3.96223232
12Abnormal ciliary motility (HP:0012262)3.92389748
13Hyperventilation (HP:0002883)3.79966871
14Focal seizures (HP:0007359)3.71192013
15True hermaphroditism (HP:0010459)3.66196144
16Genital tract atresia (HP:0001827)3.47017104
17Poor coordination (HP:0002370)3.46396461
18Vaginal atresia (HP:0000148)3.42636156
19Septo-optic dysplasia (HP:0100842)3.37843317
20Abnormality of midbrain morphology (HP:0002418)3.35029383
21Molar tooth sign on MRI (HP:0002419)3.35029383
22Abnormal respiratory epithelium morphology (HP:0012253)3.22612505
23Abnormal respiratory motile cilium morphology (HP:0005938)3.22612505
24Absence seizures (HP:0002121)3.22062821
25Abnormal hair whorl (HP:0010721)3.17259038
26Rhinitis (HP:0012384)3.15742415
27Limb dystonia (HP:0002451)3.05593607
28Oligodactyly (hands) (HP:0001180)3.04057927
29Hemiparesis (HP:0001269)3.01194947
30Epileptic encephalopathy (HP:0200134)2.99735173
31Action tremor (HP:0002345)2.93555221
32Aplasia/Hypoplasia of the lens (HP:0008063)2.90265215
33Anosmia (HP:0000458)2.84795310
34Optic nerve hypoplasia (HP:0000609)2.83292199
35Bifid tongue (HP:0010297)2.81199185
36Blue irides (HP:0000635)2.80103105
37Cystic liver disease (HP:0006706)2.79744338
38Dialeptic seizures (HP:0011146)2.76826324
39Truncal ataxia (HP:0002078)2.76594101
40Generalized tonic-clonic seizures (HP:0002069)2.72313569
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.68311464
42Submucous cleft hard palate (HP:0000176)2.63076486
43Polyphagia (HP:0002591)2.61354796
44Ankle clonus (HP:0011448)2.60746368
45Occipital encephalocele (HP:0002085)2.60310063
46Pancreatic cysts (HP:0001737)2.58585469
47Split foot (HP:0001839)2.55609020
48Retinal dysplasia (HP:0007973)2.53685515
49Peripheral hypomyelination (HP:0007182)2.52201976
50Chronic hepatic failure (HP:0100626)2.50559550
51Genetic anticipation (HP:0003743)2.49079968
52Absent eyebrow (HP:0002223)2.48134170
53Myokymia (HP:0002411)2.47865170
54Postaxial hand polydactyly (HP:0001162)2.44982952
55Epileptiform EEG discharges (HP:0011182)2.41588734
56Palpitations (HP:0001962)2.41028601
57Abnormal eating behavior (HP:0100738)2.38955804
58Nephronophthisis (HP:0000090)2.38232805
59Specific learning disability (HP:0001328)2.37879290
60Abnormality of macular pigmentation (HP:0008002)2.36279972
61Megalencephaly (HP:0001355)2.34144614
62Sclerocornea (HP:0000647)2.33781525
63Bradycardia (HP:0001662)2.31195773
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30980300
65Lissencephaly (HP:0001339)2.29400995
66Hypoplastic left heart (HP:0004383)2.28889641
67Spastic gait (HP:0002064)2.28608389
68Hypsarrhythmia (HP:0002521)2.28042421
69EEG with generalized epileptiform discharges (HP:0011198)2.27427864
70Gaze-evoked nystagmus (HP:0000640)2.26917806
71Visual hallucinations (HP:0002367)2.24276369
72Preaxial hand polydactyly (HP:0001177)2.23775489
73Slow-growing hair (HP:0002217)2.21420859
74Abnormality of hair growth rate (HP:0011363)2.21420859
75Xerostomia (HP:0000217)2.21025736
76Pachygyria (HP:0001302)2.20455644
77Cortical dysplasia (HP:0002539)2.20032250
78Urinary urgency (HP:0000012)2.18603109
79Tubulointerstitial nephritis (HP:0001970)2.18110043
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.17481681
81Oligodactyly (HP:0012165)2.16677373
82Narrow nasal bridge (HP:0000446)2.13568795
83Hepatoblastoma (HP:0002884)2.12743182
84Abnormality of cochlea (HP:0000375)2.10886044
85Sleep apnea (HP:0010535)2.09325729
86Abnormality of the intervertebral disk (HP:0005108)2.09200737
87Absent speech (HP:0001344)2.05530286
88Abnormality of the renal medulla (HP:0100957)2.03231551
89Abnormality of salivation (HP:0100755)2.01935402
90Left ventricular hypertrophy (HP:0001712)2.01924693
91Postaxial foot polydactyly (HP:0001830)2.00201400
92Anophthalmia (HP:0000528)2.00155174
93Curly hair (HP:0002212)1.96177844
94Agitation (HP:0000713)1.95414874
95Progressive cerebellar ataxia (HP:0002073)1.95136756
96Broad-based gait (HP:0002136)1.94490138
97Protruding tongue (HP:0010808)1.93425592
98Abnormality of the pubic bones (HP:0003172)1.93180528
99Drooling (HP:0002307)1.92390234
100Excessive salivation (HP:0003781)1.92390234
101Broad foot (HP:0001769)1.91208422
102Dental crowding (HP:0000678)1.89544521
103Morphological abnormality of the middle ear (HP:0008609)1.89331820
104Morphological abnormality of the inner ear (HP:0011390)1.89214661
105Absent eyelashes (HP:0000561)1.87777801
106Urinary bladder sphincter dysfunction (HP:0002839)1.87489317
107Ulnar claw (HP:0001178)1.86399833
108Abnormality of binocular vision (HP:0011514)1.85604260
109Diplopia (HP:0000651)1.85604260
110Syncope (HP:0001279)1.85177200
111Poor eye contact (HP:0000817)1.84909446
112Abnormality of the septum pellucidum (HP:0007375)1.84792037
113White forelock (HP:0002211)1.84629410
114Furrowed tongue (HP:0000221)1.83205599
115Hypoplasia of the corpus callosum (HP:0002079)1.82530489
116Hypoplastic heart (HP:0001961)1.82478874
117Congenital sensorineural hearing impairment (HP:0008527)1.81804572
118Hypoplastic pelvis (HP:0008839)1.81232523
119Fetal akinesia sequence (HP:0001989)1.80246721
120Absent septum pellucidum (HP:0001331)1.80244244
121Abnormality of the corticospinal tract (HP:0002492)1.79588807
122Congenital hepatic fibrosis (HP:0002612)1.79477544
123Humeroradial synostosis (HP:0003041)1.79384569
124Synostosis involving the elbow (HP:0003938)1.79384569
125Chronic bronchitis (HP:0004469)1.78915299
126Spastic tetraplegia (HP:0002510)1.78739453
127Aganglionic megacolon (HP:0002251)1.78216252
128Abnormal social behavior (HP:0012433)1.77445102
129Impaired social interactions (HP:0000735)1.77445102
130Cutaneous finger syndactyly (HP:0010554)1.76218752
131Type II lissencephaly (HP:0007260)1.75736343
132Adrenal hypoplasia (HP:0000835)1.74248896
133Male pseudohermaphroditism (HP:0000037)1.73168093
134Absent/shortened dynein arms (HP:0200106)1.72606007
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.72606007
136Akinesia (HP:0002304)1.71657367
137Dysdiadochokinesis (HP:0002075)1.71459895
138Short foot (HP:0001773)1.70986054
139Methylmalonic acidemia (HP:0002912)1.70866412
140Abnormality of pain sensation (HP:0010832)1.70599718
141Impaired pain sensation (HP:0007328)1.70599718
142Exotropia (HP:0000577)1.70309129
143Amblyopia (HP:0000646)1.69975592
144Median cleft lip (HP:0000161)1.69586704
145Narrow forehead (HP:0000341)1.68250062
146Facial cleft (HP:0002006)1.68169150
147Cutaneous syndactyly (HP:0012725)1.67319628
148Inability to walk (HP:0002540)1.65973884
149Retinitis pigmentosa (HP:0000510)1.65082888
150Postural instability (HP:0002172)1.65077738
151Supranuclear gaze palsy (HP:0000605)1.62945446
152Abnormality of the lower motor neuron (HP:0002366)1.62739992
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61732990
154Hypoplasia of the brainstem (HP:0002365)1.61732990
155Midline defect of the nose (HP:0004122)1.60904408
156Hemiplegia (HP:0002301)1.60822734
157Intellectual disability, severe (HP:0010864)1.59843890
158Morphological abnormality of the pyramidal tract (HP:0002062)1.59665531
159Impaired smooth pursuit (HP:0007772)1.59206213
160Neoplasm of the heart (HP:0100544)1.59012187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.82664324
2CASK4.26774446
3RIPK14.17460307
4PRPF4B3.97133631
5AKT33.55218037
6BRAF3.43414241
7PIM23.14933118
8MAP2K72.42879548
9ERBB32.25547471
10MAPK132.21726589
11MARK12.15486062
12DAPK22.14563812
13BMPR22.08504684
14STK242.05533874
15PLK21.86651722
16PNCK1.84281278
17SGK21.83886916
18PINK11.82657922
19BCR1.74917114
20TYRO31.74348847
21MAP3K41.66620702
22NTRK31.64502683
23NTRK21.62976276
24CAMKK21.56996287
25STK38L1.53943407
26PAK61.52992361
27EPHA41.47022652
28SGK2231.42993609
29SGK4941.42993609
30MINK11.42512135
31MAPK151.28706131
32NTRK11.23442911
33SIK31.22931552
34SGK31.16651202
35PAK31.16285105
36DAPK11.15061552
37RPS6KA21.14267710
38TNIK1.08334555
39RAF11.07628171
40GRK51.07093357
41PRKD31.06119425
42TRIM281.04201469
43CCNB11.01501995
44PLK31.01493177
45CAMK11.01277698
46MAP2K40.97745041
47PKN10.92984340
48INSRR0.92234166
49BMPR1B0.90918638
50PRKCE0.90729550
51EPHA30.84793829
52CAMK2B0.82750821
53MARK20.81053894
54MAP3K120.80309194
55TAOK20.79605849
56FRK0.77323766
57DDR20.75349026
58MAPKAPK30.75320152
59UHMK10.73285057
60CSNK1G20.72038474
61STK110.67665562
62CSNK1A1L0.67172609
63PRKCG0.66999288
64CAMK40.64967545
65CAMK2G0.63011907
66CAMK1G0.62513239
67CSNK1G30.61913290
68MAP4K20.61559572
69OXSR10.61361533
70CDK50.61226472
71CAMK1D0.60687515
72ERBB20.58117864
73LATS10.57321197
74FGFR20.57198355
75MAP3K70.56362915
76CDK140.56039787
77MAP3K60.55729733
78PRKCH0.55383324
79LATS20.55344656
80DYRK30.55136547
81FGR0.54405600
82CDK150.53818531
83CDK180.53233179
84KSR10.50261180
85DYRK20.50106217
86TNK20.50037315
87MAP3K90.47289357
88CSNK1A10.47237834
89CDK11A0.46737480
90STK380.46486461
91TAOK10.45775740
92YES10.44808953
93PRKCZ0.44547476
94MUSK0.44020597
95CDK80.43449734
96RPS6KA30.43123869
97PRKAA10.43083190
98EPHB20.42662057
99PHKG20.42311353
100PHKG10.42311353
101SIK20.42186434
102RPS6KA40.41959466
103CSNK1D0.41783183
104CAMK2A0.40737623
105DYRK1A0.39896814
106CAMK2D0.39645358
107CAMKK10.38771634
108ICK0.38378339
109HIPK20.38366170
110PRKCI0.37939853
111EEF2K0.37753881
112RET0.37615671
113GSK3B0.37028817
114CSNK1E0.36167932
115CDK30.36143021
116CSNK1G10.35932779
117WNK40.33893841
118RPS6KA60.33702762
119CDK190.33681495
120RPS6KC10.33236817
121RPS6KL10.33236817
122BRD40.32492600
123ERBB40.32334255
124MAP3K100.32071183
125MAPK80.31851334
126CDC42BPA0.28089737
127MAPKAPK50.27018427
128SRPK10.26673430
129RPS6KB10.26328209
130ADRBK20.25268448
131PRKG10.25103471
132LMTK20.24731299
133MAPK90.24466262
134WNK30.23276181
135SGK10.21870571
136GRK10.21809081
137MAP3K30.20995290
138NEK60.20720935
139PRKACA0.20542086
140PTK2B0.18548503
141FER0.18403353
142MAPK100.18360621

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.00984304
2Phototransduction_Homo sapiens_hsa047443.40329866
3Morphine addiction_Homo sapiens_hsa050323.11711575
4Circadian entrainment_Homo sapiens_hsa047133.03396626
5GABAergic synapse_Homo sapiens_hsa047273.00120117
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95112953
7Synaptic vesicle cycle_Homo sapiens_hsa047212.94865032
8Collecting duct acid secretion_Homo sapiens_hsa049662.84107605
9Taste transduction_Homo sapiens_hsa047422.74745350
10Serotonergic synapse_Homo sapiens_hsa047262.71708784
11Dopaminergic synapse_Homo sapiens_hsa047282.58704811
12Glutamatergic synapse_Homo sapiens_hsa047242.53529494
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48656729
14Cholinergic synapse_Homo sapiens_hsa047252.35346798
15Insulin secretion_Homo sapiens_hsa049112.28828822
16Nicotine addiction_Homo sapiens_hsa050332.16997144
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66929894
18Amphetamine addiction_Homo sapiens_hsa050311.61208989
19Long-term potentiation_Homo sapiens_hsa047201.49868593
20Endometrial cancer_Homo sapiens_hsa052131.31080164
21Vibrio cholerae infection_Homo sapiens_hsa051101.30165647
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27839600
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24016293
24Pyruvate metabolism_Homo sapiens_hsa006201.18110678
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15809438
26Alcoholism_Homo sapiens_hsa050341.15116217
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14874689
28Cardiac muscle contraction_Homo sapiens_hsa042601.10841479
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08176346
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08123849
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06913943
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05937193
33Ras signaling pathway_Homo sapiens_hsa040141.04877207
34Circadian rhythm_Homo sapiens_hsa047101.01744565
35Gastric acid secretion_Homo sapiens_hsa049711.00308085
36Axon guidance_Homo sapiens_hsa043600.97663598
37Renin secretion_Homo sapiens_hsa049240.96666410
38Salivary secretion_Homo sapiens_hsa049700.96589242
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95657638
40Colorectal cancer_Homo sapiens_hsa052100.95024825
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94682055
42Calcium signaling pathway_Homo sapiens_hsa040200.94609219
43Hedgehog signaling pathway_Homo sapiens_hsa043400.93923580
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91750893
45Hippo signaling pathway_Homo sapiens_hsa043900.91075253
46Basal cell carcinoma_Homo sapiens_hsa052170.90200309
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89096461
48ErbB signaling pathway_Homo sapiens_hsa040120.84950644
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84241013
50cAMP signaling pathway_Homo sapiens_hsa040240.83224338
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.82488467
52Fatty acid biosynthesis_Homo sapiens_hsa000610.80344998
53Long-term depression_Homo sapiens_hsa047300.79815037
54Cocaine addiction_Homo sapiens_hsa050300.79190439
55Dorso-ventral axis formation_Homo sapiens_hsa043200.78003692
56Hepatitis C_Homo sapiens_hsa051600.76911102
57AMPK signaling pathway_Homo sapiens_hsa041520.73513098
58GnRH signaling pathway_Homo sapiens_hsa049120.73027162
59Dilated cardiomyopathy_Homo sapiens_hsa054140.71707237
60Oxytocin signaling pathway_Homo sapiens_hsa049210.69865553
61Melanoma_Homo sapiens_hsa052180.69700496
62Gap junction_Homo sapiens_hsa045400.68876079
63Bile secretion_Homo sapiens_hsa049760.67594501
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66745087
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.64927932
66Tight junction_Homo sapiens_hsa045300.63931533
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63592021
68Lysine degradation_Homo sapiens_hsa003100.63493224
69Chemokine signaling pathway_Homo sapiens_hsa040620.63140765
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62477949
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61973299
72Melanogenesis_Homo sapiens_hsa049160.61709537
73Alzheimers disease_Homo sapiens_hsa050100.59191877
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58702376
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58118941
76Choline metabolism in cancer_Homo sapiens_hsa052310.57496488
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.56376320
78Glioma_Homo sapiens_hsa052140.55940853
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52789046
80Insulin signaling pathway_Homo sapiens_hsa049100.52526352
81Oxidative phosphorylation_Homo sapiens_hsa001900.51194857
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51078474
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50667815
84Type II diabetes mellitus_Homo sapiens_hsa049300.50632359
85Pancreatic cancer_Homo sapiens_hsa052120.49740823
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49697014
87Inositol phosphate metabolism_Homo sapiens_hsa005620.48972036
88ABC transporters_Homo sapiens_hsa020100.47350452
89Estrogen signaling pathway_Homo sapiens_hsa049150.47172977
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44919548
91Regulation of autophagy_Homo sapiens_hsa041400.43343808
92Steroid biosynthesis_Homo sapiens_hsa001000.42955213
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42721324
94mTOR signaling pathway_Homo sapiens_hsa041500.42668703
95Glucagon signaling pathway_Homo sapiens_hsa049220.41860640
96Notch signaling pathway_Homo sapiens_hsa043300.41684843
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41513539
98Ovarian steroidogenesis_Homo sapiens_hsa049130.41379483
99Fatty acid metabolism_Homo sapiens_hsa012120.38611757
100Butanoate metabolism_Homo sapiens_hsa006500.38081547
101Vitamin B6 metabolism_Homo sapiens_hsa007500.36388022
102Sphingolipid metabolism_Homo sapiens_hsa006000.34913097
103Prion diseases_Homo sapiens_hsa050200.34410009
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34026448
105Phagosome_Homo sapiens_hsa041450.32202706
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32030663
107beta-Alanine metabolism_Homo sapiens_hsa004100.31446654
108MAPK signaling pathway_Homo sapiens_hsa040100.30997882
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29686609
110Rheumatoid arthritis_Homo sapiens_hsa053230.29095836
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27971183
112Parkinsons disease_Homo sapiens_hsa050120.26868726
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26557845
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25819189
115Huntingtons disease_Homo sapiens_hsa050160.24934756
116Ether lipid metabolism_Homo sapiens_hsa005650.23186064
117Rap1 signaling pathway_Homo sapiens_hsa040150.22464981
118Oocyte meiosis_Homo sapiens_hsa041140.22424348
119Thyroid hormone synthesis_Homo sapiens_hsa049180.21513426
120Propanoate metabolism_Homo sapiens_hsa006400.20809866
121Non-small cell lung cancer_Homo sapiens_hsa052230.18930345
122Wnt signaling pathway_Homo sapiens_hsa043100.17281829
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17165575
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.16287896
125Prostate cancer_Homo sapiens_hsa052150.15731586
126FoxO signaling pathway_Homo sapiens_hsa040680.15515674
127Pathways in cancer_Homo sapiens_hsa052000.15062743
128Pancreatic secretion_Homo sapiens_hsa049720.13777287
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13568905

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