FLNB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.15439661
2cell adhesion mediated by integrin (GO:0033627)4.89712644
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.76264987
4hemidesmosome assembly (GO:0031581)4.47776414
5endodermal cell differentiation (GO:0035987)4.35451891
6apoptotic cell clearance (GO:0043277)4.26524082
7cell-substrate junction assembly (GO:0007044)4.18127951
8regulation of hippo signaling (GO:0035330)4.18075753
9epithelial cell-cell adhesion (GO:0090136)4.17697727
10regulation of integrin activation (GO:0033623)4.16254789
11polarized epithelial cell differentiation (GO:0030859)4.05577118
12chondrocyte proliferation (GO:0035988)4.03012963
13wound healing, spreading of epidermal cells (GO:0035313)3.99199627
14hippo signaling (GO:0035329)3.94072346
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.90811335
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.77861271
17basement membrane organization (GO:0071711)3.72535370
18adherens junction assembly (GO:0034333)3.71077287
19negative regulation of fatty acid transport (GO:2000192)3.70358160
20positive regulation of endothelial cell apoptotic process (GO:2000353)3.69187609
21skin morphogenesis (GO:0043589)3.66057537
22collagen fibril organization (GO:0030199)3.63817562
23COPI coating of Golgi vesicle (GO:0048205)3.63367076
24Golgi transport vesicle coating (GO:0048200)3.63367076
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.59373784
26plasma membrane repair (GO:0001778)3.54677192
27paraxial mesoderm development (GO:0048339)3.52966149
28cellular response to vitamin D (GO:0071305)3.44948754
29semaphorin-plexin signaling pathway (GO:0071526)3.44859462
30cell migration involved in sprouting angiogenesis (GO:0002042)3.43737823
31establishment of apical/basal cell polarity (GO:0035089)3.40637089
32substrate adhesion-dependent cell spreading (GO:0034446)3.33535362
33wound healing, spreading of cells (GO:0044319)3.31960442
34regulation of gene silencing by RNA (GO:0060966)3.30277660
35regulation of posttranscriptional gene silencing (GO:0060147)3.30277660
36regulation of gene silencing by miRNA (GO:0060964)3.30277660
37activation of Rac GTPase activity (GO:0032863)3.29510220
38negative regulation of keratinocyte proliferation (GO:0010839)3.28999429
39protein localization to cell surface (GO:0034394)3.24470922
40gap junction assembly (GO:0016264)3.23963049
41negative regulation of chondrocyte differentiation (GO:0032331)3.23796762
42mesodermal cell differentiation (GO:0048333)3.22740367
43nuclear pore complex assembly (GO:0051292)3.20168957
44endocardial cushion development (GO:0003197)3.18648252
45regulation of tight junction assembly (GO:2000810)3.16793983
46blood vessel endothelial cell migration (GO:0043534)3.16192771
47hypotonic response (GO:0006971)3.13521615
48positive regulation of SMAD protein import into nucleus (GO:0060391)3.11573761
49cell-substrate adherens junction assembly (GO:0007045)3.09547619
50focal adhesion assembly (GO:0048041)3.09547619
51retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09070932
52COPII vesicle coating (GO:0048208)3.08818840
53heterochromatin organization (GO:0070828)3.08289001
54regulation of SMAD protein import into nucleus (GO:0060390)3.07565909
55protein retention in ER lumen (GO:0006621)3.06718446
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04409465
57sequestering of extracellular ligand from receptor (GO:0035581)3.03671111
58regulation of water loss via skin (GO:0033561)3.00900937
59endothelial cell chemotaxis (GO:0035767)3.00852001
60vascular endothelial growth factor signaling pathway (GO:0038084)2.99400369
61regulation of cholesterol homeostasis (GO:2000188)2.94967759
62activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.94881780
63surfactant homeostasis (GO:0043129)2.94829633
64branching involved in mammary gland duct morphogenesis (GO:0060444)2.94234485
65nuclear pore organization (GO:0006999)2.92113169
66cellular response to vitamin (GO:0071295)2.92067091
67stress fiber assembly (GO:0043149)2.91919015
68substrate-dependent cell migration (GO:0006929)2.90461341
69branching involved in salivary gland morphogenesis (GO:0060445)2.89169055
70regulation of translational fidelity (GO:0006450)2.88358266
71insulin-like growth factor receptor signaling pathway (GO:0048009)2.88295453
72renal filtration (GO:0097205)2.86766488
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84531661
74peptidyl-proline hydroxylation (GO:0019511)2.83828386
75regulation of transforming growth factor beta1 production (GO:0032908)2.81987878
76mRNA transcription (GO:0009299)2.81412943
77positive regulation of nuclease activity (GO:0032075)2.81210610
78glomerular visceral epithelial cell development (GO:0072015)2.78850385
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78740373
80negative regulation of smooth muscle cell migration (GO:0014912)2.77854666
81endothelial cell morphogenesis (GO:0001886)2.75878373
82establishment of monopolar cell polarity (GO:0061162)2.75049915
83establishment or maintenance of monopolar cell polarity (GO:0061339)2.75049915
84trophectodermal cell differentiation (GO:0001829)2.73887787
85adherens junction organization (GO:0034332)2.70346006
86anterior/posterior axis specification, embryo (GO:0008595)2.70258758
87regulation of transforming growth factor beta2 production (GO:0032909)2.70086275
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.67614757
89axon extension involved in axon guidance (GO:0048846)2.67614757
90positive regulation of osteoblast proliferation (GO:0033690)2.67307829
91membrane protein ectodomain proteolysis (GO:0006509)2.67087709
92negative regulation of anoikis (GO:2000811)2.66415738
93cell junction assembly (GO:0034329)2.63975416
94apoptotic process involved in morphogenesis (GO:0060561)2.62034675
95protein hydroxylation (GO:0018126)2.61967082
96endoplasmic reticulum unfolded protein response (GO:0030968)2.61781776
97regulation of apoptotic cell clearance (GO:2000425)2.61500309
98glomerular epithelial cell development (GO:0072310)2.60963515
99establishment of skin barrier (GO:0061436)2.59344967
100labyrinthine layer blood vessel development (GO:0060716)2.59271187
101vesicle coating (GO:0006901)2.58141137
102NLS-bearing protein import into nucleus (GO:0006607)2.55577271
103regulation of nuclease activity (GO:0032069)2.55298992
104actin filament depolymerization (GO:0030042)2.54528044
105embryonic process involved in female pregnancy (GO:0060136)2.52448504
106placenta blood vessel development (GO:0060674)2.52402416
107protein heterotrimerization (GO:0070208)2.52039758
108cell junction organization (GO:0034330)2.50332522
109* cytoskeletal anchoring at plasma membrane (GO:0007016)2.50074652
110extracellular matrix disassembly (GO:0022617)2.50049168
111protein localization to endosome (GO:0036010)2.50023179
112low-density lipoprotein particle clearance (GO:0034383)2.50007756
113positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.49975999
114cellular response to unfolded protein (GO:0034620)2.49775877
115regulation of cardioblast differentiation (GO:0051890)2.47733966
116cell-cell junction assembly (GO:0007043)2.47641241
117keratinocyte proliferation (GO:0043616)2.47184367
118regulation of cell fate specification (GO:0042659)2.47057901
119regulation of mitotic spindle organization (GO:0060236)2.46358337
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46187761
121tight junction assembly (GO:0070830)2.45717713
122positive regulation of p38MAPK cascade (GO:1900745)2.45236613
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44547558
124regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.44206181
125folic acid-containing compound biosynthetic process (GO:0009396)2.44165919
126negative regulation of fibrinolysis (GO:0051918)2.43817060
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43699646
128regulation of glucose import in response to insulin stimulus (GO:2001273)2.42578971
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.42308779
130embryonic foregut morphogenesis (GO:0048617)2.41359870
131regulation of plasminogen activation (GO:0010755)2.39912069
1324-hydroxyproline metabolic process (GO:0019471)2.39896434
133cellular response to interferon-alpha (GO:0035457)2.39353018
134glucocorticoid receptor signaling pathway (GO:0042921)2.38677709
135atrioventricular valve morphogenesis (GO:0003181)2.38507419
136protein localization to microtubule (GO:0035372)2.37238045
137actin filament bundle assembly (GO:0051017)2.35210296
138actin filament bundle organization (GO:0061572)2.35210296
139regulation of transforming growth factor beta production (GO:0071634)2.34886669
140negative regulation of cell fate specification (GO:0009996)2.34252911
141regulation of cholesterol biosynthetic process (GO:0045540)2.33964968
142positive regulation of hormone biosynthetic process (GO:0046886)2.33871325
143positive regulation of protein localization to plasma membrane (GO:1903078)2.33028948
144mammary gland epithelial cell proliferation (GO:0033598)2.33001329
145positive regulation of epidermal cell differentiation (GO:0045606)2.31374592
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30541728
147regulation of anoikis (GO:2000209)2.29174582
148regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.28985364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.64652538
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.92886820
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.57182315
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.55007335
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.52474303
6CLOCK_20551151_ChIP-Seq_293T_Human2.67610415
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44468406
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41358074
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36024982
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.35858850
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.30160151
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25162374
13* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22989769
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09173263
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05385565
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.04332170
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99682731
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99682731
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95605402
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91464372
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90776907
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89639825
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.89070044
24* ATF3_27146783_Chip-Seq_COLON_Human1.88265138
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86558556
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82031923
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.79583564
28ZNF263_19887448_ChIP-Seq_K562_Human1.76597456
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73499355
30* ESR2_21235772_ChIP-Seq_MCF-7_Human1.72959749
31E2F7_22180533_ChIP-Seq_HELA_Human1.71502120
32* FOXO3_23340844_ChIP-Seq_DLD1_Human1.71165180
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70901166
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69388094
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69011918
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68147109
37* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66560123
38AR_21909140_ChIP-Seq_LNCAP_Human1.66418674
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.65339673
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.61145339
41* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57073358
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55979192
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54525486
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52617670
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48430047
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46527755
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45999076
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.45579965
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43967992
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43439196
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43026457
52LXR_22292898_ChIP-Seq_THP-1_Human1.42761787
53* CJUN_26792858_Chip-Seq_BT549_Human1.41947724
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41044098
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40690674
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39735529
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38850151
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38347169
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38264729
60GATA6_25053715_ChIP-Seq_YYC3_Human1.38205626
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38052289
62* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37844134
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.37645380
64EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37569818
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.37492394
66TP53_22127205_ChIP-Seq_IMR90_Human1.37170059
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35393276
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32964364
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31662212
70MYC_22102868_ChIP-Seq_BL_Human1.30504120
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29709069
72* RXR_22158963_ChIP-Seq_LIVER_Mouse1.28019113
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27948765
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27879707
75KDM2B_26808549_Chip-Seq_DND41_Human1.27483008
76* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26909176
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24780231
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23336994
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22725687
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.20112116
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.20112116
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.19745658
83SOX2_20726797_ChIP-Seq_SW620_Human1.19188522
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19080456
85TP53_16413492_ChIP-PET_HCT116_Human1.18055468
86AHR_22903824_ChIP-Seq_MCF-7_Human1.17378181
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16834227
88* TCF7_22412390_ChIP-Seq_EML_Mouse1.15846134
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15695341
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15695341
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15695341
92* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15447426
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14990374
94* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14814003
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13647413
96* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13356687
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12844476
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12818088
99* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11943309
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11861930
101* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11723755
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11669837
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11560663
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11201014
105* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10035313
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09840778
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09793209
108* LXR_22158963_ChIP-Seq_LIVER_Mouse1.09126218
109NCOR1_26117541_ChIP-Seq_K562_Human1.08137393
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.07039319
111* KLF5_25053715_ChIP-Seq_YYC3_Human1.06781809
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.06338866
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.05647177
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05084836
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05078183
116KDM2B_26808549_Chip-Seq_K562_Human1.03943327
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03843332
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03325075
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03157928
120* CHD1_26751641_Chip-Seq_LNCaP_Human1.03042715
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.02151495
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01686529
123* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01357227
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01022124
125* GATA4_25053715_ChIP-Seq_YYC3_Human1.00828613
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.98522585
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98148999
128* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97757143
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.92479559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.89966167
2MP0008438_abnormal_cutaneous_collagen4.64736349
3MP0010352_gastrointestinal_tract_polyps3.93086559
4MP0004272_abnormal_basement_membrane3.19969701
5MP0003566_abnormal_cell_adhesion3.17709841
6MP0005275_abnormal_skin_tensile3.10762066
7MP0005623_abnormal_meninges_morphology3.05090918
8MP0010234_abnormal_vibrissa_follicle2.84567622
9MP0002877_abnormal_melanocyte_morpholog2.60859932
10MP0005409_darkened_coat_color2.52802065
11MP0000579_abnormal_nail_morphology2.49695262
12MP0005023_abnormal_wound_healing2.32205522
13MP0005076_abnormal_cell_differentiation2.21471868
14MP0003279_aneurysm2.19498531
15MP0000762_abnormal_tongue_morphology2.08041083
16MP0000537_abnormal_urethra_morphology2.04517703
17MP0003300_gastrointestinal_ulcer2.03570538
18* MP0003091_abnormal_cell_migration1.98604107
19MP0003283_abnormal_digestive_organ1.95122828
20MP0009053_abnormal_anal_canal1.94868956
21MP0003950_abnormal_plasma_membrane1.93641051
22MP0006054_spinal_hemorrhage1.91694347
23MP0000566_synostosis1.81416972
24MP0005503_abnormal_tendon_morphology1.71995054
25MP0004264_abnormal_extraembryonic_tissu1.70682716
26MP0003045_fibrosis1.68881941
27MP0010030_abnormal_orbit_morphology1.66802805
28MP0005360_urolithiasis1.66566551
29MP0001958_emphysema1.65744968
30MP0001849_ear_inflammation1.61661804
31MP0009384_cardiac_valve_regurgitation1.60498694
32MP0004858_abnormal_nervous_system1.58629174
33MP0000733_abnormal_muscle_development1.58252968
34MP0002060_abnormal_skin_morphology1.57275708
35MP0001348_abnormal_lacrimal_gland1.55477722
36MP0004233_abnormal_muscle_weight1.54344275
37MP0003191_abnormal_cellular_cholesterol1.53483368
38MP0005451_abnormal_body_composition1.45263965
39MP0000678_abnormal_parathyroid_gland1.39101842
40MP0003315_abnormal_perineum_morphology1.33310644
41MP0003941_abnormal_skin_development1.32028901
42MP0009840_abnormal_foam_cell1.31821656
43MP0002098_abnormal_vibrissa_morphology1.31192874
44MP0004782_abnormal_surfactant_physiolog1.28071967
45MP0005508_abnormal_skeleton_morphology1.27225652
46MP0000383_abnormal_hair_follicle1.26392656
47MP0002254_reproductive_system_inflammat1.25640558
48MP0002086_abnormal_extraembryonic_tissu1.24032693
49* MP0002896_abnormal_bone_mineralization1.23551542
50MP0000767_abnormal_smooth_muscle1.23230463
51MP0001915_intracranial_hemorrhage1.22513639
52MP0003385_abnormal_body_wall1.21573634
53MP0005257_abnormal_intraocular_pressure1.21186834
54MP0004197_abnormal_fetal_growth/weight/1.19479481
55MP0002168_other_aberrant_phenotype1.19020313
56MP0001879_abnormal_lymphatic_vessel1.17893745
57MP0003115_abnormal_respiratory_system1.16861568
58MP0000428_abnormal_craniofacial_morphol1.16711694
59MP0001299_abnormal_eye_distance/1.15913211
60MP0003453_abnormal_keratinocyte_physiol1.15214348
61MP0010307_abnormal_tumor_latency1.14390605
62MP0002084_abnormal_developmental_patter1.12412581
63MP0010771_integument_phenotype1.11983171
64MP0003984_embryonic_growth_retardation1.11609713
65MP0002088_abnormal_embryonic_growth/wei1.11202281
66MP0001243_abnormal_dermal_layer1.08656662
67MP0005367_renal/urinary_system_phenotyp1.08606783
68MP0000516_abnormal_urinary_system1.08606783
69MP0010368_abnormal_lymphatic_system1.07973543
70MP0005380_embryogenesis_phenotype1.07617560
71MP0001672_abnormal_embryogenesis/_devel1.07617560
72MP0002697_abnormal_eye_size1.06715848
73* MP0002925_abnormal_cardiovascular_devel1.06442652
74MP0000377_abnormal_hair_follicle1.04560578
75MP0001730_embryonic_growth_arrest1.00771144
76MP0003937_abnormal_limbs/digits/tail_de0.98993746
77MP0003119_abnormal_digestive_system0.97890687
78MP0002089_abnormal_postnatal_growth/wei0.96869284
79MP0002295_abnormal_pulmonary_circulatio0.96789289
80MP0000534_abnormal_ureter_morphology0.96070819
81MP0002796_impaired_skin_barrier0.95528741
82MP0003935_abnormal_craniofacial_develop0.94137833
83MP0005375_adipose_tissue_phenotype0.93777197
84MP0003868_abnormal_feces_composition0.92995078
85MP0009780_abnormal_chondrocyte_physiolo0.92938675
86MP0000432_abnormal_head_morphology0.92532581
87MP0002085_abnormal_embryonic_tissue0.92455695
88MP0000013_abnormal_adipose_tissue0.91327404
89MP0002111_abnormal_tail_morphology0.90668692
90* MP0001614_abnormal_blood_vessel0.89508766
91MP0006138_congestive_heart_failure0.89007083
92MP0002006_tumorigenesis0.88396885
93MP0003755_abnormal_palate_morphology0.88304963
94MP0003942_abnormal_urinary_system0.88183045
95MP0001697_abnormal_embryo_size0.87566675
96MP0005501_abnormal_skin_physiology0.87524042
97MP0001661_extended_life_span0.87185118
98MP0002166_altered_tumor_susceptibility0.86115768
99MP0008260_abnormal_autophagy0.85316469
100MP0000003_abnormal_adipose_tissue0.85307624
101MP0000467_abnormal_esophagus_morphology0.85212442
102MP0002092_abnormal_eye_morphology0.84192990
103MP0004947_skin_inflammation0.84161154
104MP0010678_abnormal_skin_adnexa0.83324219
105MP0002128_abnormal_blood_circulation0.81087629
106MP0002282_abnormal_trachea_morphology0.80528245
107MP0005666_abnormal_adipose_tissue0.80342169
108MP0002234_abnormal_pharynx_morphology0.80027944
109MP0000858_altered_metastatic_potential0.79285645
110MP0000350_abnormal_cell_proliferation0.78397860
111MP0005197_abnormal_uvea_morphology0.78313095
112MP0000462_abnormal_digestive_system0.75506485
113MP0009931_abnormal_skin_appearance0.75243481
114MP0008004_abnormal_stomach_pH0.75008721
115MP0004185_abnormal_adipocyte_glucose0.74358037
116MP0003329_amyloid_beta_deposits0.74130535
117MP0000627_abnormal_mammary_gland0.73666072
118MP0005390_skeleton_phenotype0.73385269
119MP0010630_abnormal_cardiac_muscle0.73283877
120* MP0000163_abnormal_cartilage_morphology0.72296121
121MP0001216_abnormal_epidermal_layer0.71704635
122MP0004957_abnormal_blastocyst_morpholog0.71066738
123* MP0002080_prenatal_lethality0.69032825
124* MP0005621_abnormal_cell_physiology0.68071446
125MP0003252_abnormal_bile_duct0.67610332
126MP0002009_preneoplasia0.67605419
127MP0000750_abnormal_muscle_regeneration0.67455168
128* MP0002113_abnormal_skeleton_development0.65054132
129MP0005187_abnormal_penis_morphology0.64653228
130MP0005248_abnormal_Harderian_gland0.64359943
131MP0005193_abnormal_anterior_eye0.64212998
132MP0003567_abnormal_fetal_cardiomyocyte0.63875061

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.64658887
2Premature rupture of membranes (HP:0001788)5.63781147
3Atrophic scars (HP:0001075)4.36994063
4Cerebral aneurysm (HP:0004944)4.35086593
5* Shallow orbits (HP:0000586)3.86683107
6Peritonitis (HP:0002586)3.77462687
7Ankle contracture (HP:0006466)3.54234564
8Onycholysis (HP:0001806)3.52920083
9Fragile nails (HP:0001808)3.42132764
10Aortic dissection (HP:0002647)3.38355335
11Wrist flexion contracture (HP:0001239)3.37586507
12Fragile skin (HP:0001030)3.23110340
13Dilatation of the ascending aorta (HP:0005111)3.11229833
14Mitral valve prolapse (HP:0001634)3.04097014
15Aortic aneurysm (HP:0004942)2.98439136
16Distal upper limb amyotrophy (HP:0007149)2.96607921
17Upper limb amyotrophy (HP:0009129)2.96607921
18Genu recurvatum (HP:0002816)2.93787947
19Plantar hyperkeratosis (HP:0007556)2.90660734
20Right ventricular cardiomyopathy (HP:0011663)2.90520119
21Natal tooth (HP:0000695)2.87208188
22Aneurysm (HP:0002617)2.79640033
23Advanced eruption of teeth (HP:0006288)2.78034811
24Bladder diverticulum (HP:0000015)2.74221900
25Broad metatarsal (HP:0001783)2.73539411
26Ulnar bowing (HP:0003031)2.72607148
27Increased connective tissue (HP:0009025)2.68357132
28Alopecia of scalp (HP:0002293)2.66146494
29Thick nail (HP:0001805)2.63294745
30Wormian bones (HP:0002645)2.63163273
31Abnormality of nail color (HP:0100643)2.62768768
32Hand muscle atrophy (HP:0009130)2.62573486
33Nail dystrophy (HP:0008404)2.61090955
34Deep venous thrombosis (HP:0002625)2.60473707
35Increased mean platelet volume (HP:0011877)2.58592982
36Increased density of long bones (HP:0006392)2.58115256
37Hyperacusis (HP:0010780)2.57888182
38Osteolytic defects of the hand bones (HP:0009699)2.55555094
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.55555094
40* Flat acetabular roof (HP:0003180)2.48691315
41Blue sclerae (HP:0000592)2.47943418
42Bowel diverticulosis (HP:0005222)2.46489170
43Pterygium (HP:0001059)2.45909951
44Thin bony cortex (HP:0002753)2.45325069
45Cardiovascular calcification (HP:0011915)2.44970633
46Selective tooth agenesis (HP:0001592)2.39335664
47Short 4th metacarpal (HP:0010044)2.37112274
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37112274
49Soft skin (HP:0000977)2.31006596
50Vascular calcification (HP:0004934)2.30118565
51Abnormality of dentin (HP:0010299)2.29070134
52Difficulty climbing stairs (HP:0003551)2.26917913
53Milia (HP:0001056)2.19670458
54Mesomelia (HP:0003027)2.17788147
55Camptodactyly of toe (HP:0001836)2.17450440
56Abnormality of the distal phalanges of the toes (HP:0010182)2.17282720
57Abnormal platelet volume (HP:0011876)2.16067179
58Deviation of the hallux (HP:0010051)2.12477952
59Persistence of primary teeth (HP:0006335)2.11083454
60Mitral stenosis (HP:0001718)2.11017386
61Distal lower limb amyotrophy (HP:0008944)2.09629771
62Spinal rigidity (HP:0003306)2.08956345
63* Hypoplasia of dental enamel (HP:0006297)2.07470993
64Scapular winging (HP:0003691)2.07195684
65Abnormality of oral frenula (HP:0000190)2.05754650
66Neonatal short-limb short stature (HP:0008921)2.05394349
67Absent frontal sinuses (HP:0002688)2.04543048
68Abnormality of the peritoneum (HP:0002585)2.03909014
69Ridged nail (HP:0001807)2.01945465
70* Abnormal ossification of hand bones (HP:0005921)2.01309333
71* Cervical subluxation (HP:0003308)2.01243754
72* Broad face (HP:0000283)2.00562998
73Trismus (HP:0000211)1.99596215
74Vertebral arch anomaly (HP:0008438)1.97352190
75Hallux valgus (HP:0001822)1.95249274
76Vascular tortuosity (HP:0004948)1.94654900
77Hemorrhage of the eye (HP:0011885)1.94579841
78Asymmetry of the thorax (HP:0001555)1.92460354
79* Abnormality of the distal phalanx of the thumb (HP:0009617)1.91065050
80Buphthalmos (HP:0000557)1.90346475
81Elbow flexion contracture (HP:0002987)1.90017257
82Spondylolisthesis (HP:0003302)1.88864274
83Enlarged penis (HP:0000040)1.88189281
84Overgrowth (HP:0001548)1.87976297
85Vertebral compression fractures (HP:0002953)1.87707716
86* Abnormality of carpal bone ossification (HP:0006257)1.86512041
87Palmoplantar hyperkeratosis (HP:0000972)1.86304772
88Abnormality of the 4th metacarpal (HP:0010012)1.85834896
89Subacute progressive viral hepatitis (HP:0006572)1.85664745
90Disproportionate tall stature (HP:0001519)1.84584588
91Pili torti (HP:0003777)1.84270816
92Hyperextensible skin (HP:0000974)1.83497441
93* Abnormality of the acetabulum (HP:0003170)1.82759260
94Turricephaly (HP:0000262)1.82665520
95Mildly elevated creatine phosphokinase (HP:0008180)1.81578796
96Heterotopia (HP:0002282)1.81180057
97Focal segmental glomerulosclerosis (HP:0000097)1.80234445
98* Radial bowing (HP:0002986)1.79232659
99Abnormal blistering of the skin (HP:0008066)1.78408842
100Coxa vara (HP:0002812)1.78387923
101Abnormal hair laboratory examination (HP:0003328)1.77304079
102Back pain (HP:0003418)1.76885093
103Distal lower limb muscle weakness (HP:0009053)1.76601931
104Ectopia lentis (HP:0001083)1.74845161
105Femoral bowing (HP:0002980)1.74611271
106Arterial tortuosity (HP:0005116)1.74602797
107Achilles tendon contracture (HP:0001771)1.73620516
108Abnormality of the Achilles tendon (HP:0005109)1.73250995
109Glomerulosclerosis (HP:0000096)1.72739036
110Congenital glaucoma (HP:0001087)1.72343982
111* Short nail (HP:0001799)1.71633866
112Palmar hyperkeratosis (HP:0010765)1.71203677
113Cerebral inclusion bodies (HP:0100314)1.70359645
114Spastic diplegia (HP:0001264)1.70311042
115Esophageal varix (HP:0002040)1.69500737
116Knee flexion contracture (HP:0006380)1.69367547
117Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68833840
118Mitral regurgitation (HP:0001653)1.67933625
119Micronodular cirrhosis (HP:0001413)1.67591519
120Aplasia cutis congenita (HP:0001057)1.66898512
121Abnormal tarsal ossification (HP:0008369)1.66378524
122Lower limb amyotrophy (HP:0007210)1.66033287
123Coronal craniosynostosis (HP:0004440)1.65972328
124Short hallux (HP:0010109)1.65863571
125Abnormal delivery (HP:0001787)1.65845719
126Spinal cord lesions (HP:0100561)1.65624304
127Syringomyelia (HP:0003396)1.65624304
128Abnormality of the gastric mucosa (HP:0004295)1.63969090
129Proximal placement of thumb (HP:0009623)1.63941457
130Biconcave vertebral bodies (HP:0004586)1.63850025
131Entropion (HP:0000621)1.62827819
132Ureteral stenosis (HP:0000071)1.62331498
133Joint contractures involving the joints of the feet (HP:0100492)1.62132926
134Flexion contracture of toe (HP:0005830)1.62132926
135Menorrhagia (HP:0000132)1.61869043
136Flattened epiphyses (HP:0003071)1.60186393
137Lymphangioma (HP:0100764)1.60144548
138* Bowing of the arm (HP:0006488)1.59733005
139* Bowed forearm bones (HP:0003956)1.59733005
140Wide anterior fontanel (HP:0000260)1.59352619
141Long toe (HP:0010511)1.59298204
142* Broad thumb (HP:0011304)1.59126898
143Hyporeflexia of lower limbs (HP:0002600)1.58765569
144* Tibial bowing (HP:0002982)1.58636416
145Rectal prolapse (HP:0002035)1.58504407
146Acanthosis nigricans (HP:0000956)1.56912256
147Interstitial pulmonary disease (HP:0006530)1.56681253
148Ureteral obstruction (HP:0006000)1.56167374
149Ankyloglossia (HP:0010296)1.55989783
150Abnormal foot bone ossification (HP:0010675)1.55546371
151Skull defect (HP:0001362)1.55422158
152Aplasia involving bones of the extremities (HP:0009825)1.54171996
153Aplasia of the phalanges of the hand (HP:0009802)1.54171996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.41374664
2TTN4.45635448
3TRIB33.28862812
4LATS12.93769312
5PKN22.91243687
6CDK122.90395343
7DDR22.63987363
8RIPK12.50358159
9PDGFRA2.41400527
10SMG12.40109237
11EEF2K2.21891877
12PTK62.19808084
13PTK22.11656825
14LMTK22.09230995
15IRAK31.94834169
16BMX1.93597858
17MET1.75736711
18ERN11.75355571
19SIK11.75043701
20LATS21.67112639
21FER1.59303918
22PAK21.58549916
23RPS6KB21.57475091
24SCYL21.48989290
25MTOR1.47322978
26PAK41.45904370
27LRRK21.45752133
28EPHB21.42832264
29STK101.39196866
30TIE11.37664466
31MST1R1.33856155
32FRK1.29838493
33CAMK1D1.26931208
34MAP3K101.25725523
35TRPM71.22031871
36TESK11.21307619
37STK31.20523399
38FGFR11.12400737
39PASK1.01666531
40PAK31.01514479
41EPHB10.95947248
42MAP3K80.95657690
43ARAF0.91033615
44PDGFRB0.90785437
45PBK0.89290414
46DMPK0.87887251
47MAP3K30.86118548
48ALK0.84580639
49TGFBR10.83757176
50CDK60.83381607
51CAMK1G0.82234955
52MAP3K90.81619279
53AKT30.80832836
54FLT30.80811810
55BRD40.78792434
56RPS6KA40.76805801
57MAP3K60.71947627
58NEK20.71643340
59PRPF4B0.70594477
60MAPKAPK30.70027662
61NME20.69404174
62PIM20.69291968
63FGFR40.69177993
64MAP3K20.68036530
65PRKG20.67366665
66ICK0.65604373
67PRKD30.62990493
68MAP2K10.61817595
69PRKD20.61386759
70LIMK10.60884799
71MYLK0.59028075
72CDC42BPA0.58725958
73RET0.58300308
74STK38L0.58186570
75MARK20.57831120
76KDR0.55980202
77ERBB40.55044564
78WNK10.54577634
79TTK0.53448793
80EPHA30.53125676
81MELK0.51717919
82MAP2K20.51171631
83NEK10.50986481
84INSR0.50669307
85ROCK10.49367922
86SGK30.49297548
87MAP3K120.48346774
88AURKB0.44122232
89CDK40.43788382
90CDK80.43710194
91MAP2K30.43684670
92JAK10.43416542
93PAK10.43124176
94KSR20.42812662
95PRKCI0.41471317
96NEK90.41170843
97CDK90.41062866
98CDK70.41003191
99CHUK0.40557127
100RPS6KA20.40157641
101NTRK10.40052864
102MOS0.39477837
103DYRK1B0.39343919
104PDPK10.38957260
105PTK2B0.38688562
106ERBB20.38589974
107PIK3CA0.37885692
108TYRO30.37842584
109MAPK110.37055175
110EGFR0.36424255
111ILK0.35800270
112PRKCH0.35622263
113FGFR30.35153711
114SRC0.34619035
115STK240.34010435
116GSK3A0.33424431
117PRKAA20.32753494
118TGFBR20.32737573
119MAPK10.32461938
120AKT20.32160112
121ROCK20.31542216
122TAOK30.31353952
123BRAF0.29588104
124CHEK10.29433385
125EIF2AK10.29430244
126TAOK10.29217181
127STK380.28005181
128PRKD10.27666985
129MAP3K130.26358713
130KSR10.24722154

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.24474824
2Adherens junction_Homo sapiens_hsa045202.86149153
3* Focal adhesion_Homo sapiens_hsa045102.56096610
4Small cell lung cancer_Homo sapiens_hsa052222.49322383
5Bladder cancer_Homo sapiens_hsa052192.33130720
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.31160166
7* Proteoglycans in cancer_Homo sapiens_hsa052052.26931581
8Amoebiasis_Homo sapiens_hsa051462.13669301
9Hippo signaling pathway_Homo sapiens_hsa043902.06748570
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.03073371
11MicroRNAs in cancer_Homo sapiens_hsa052061.88679135
12Tight junction_Homo sapiens_hsa045301.66685237
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64804718
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.64524561
15TGF-beta signaling pathway_Homo sapiens_hsa043501.55241019
16Chronic myeloid leukemia_Homo sapiens_hsa052201.54591131
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.51617308
18p53 signaling pathway_Homo sapiens_hsa041151.50281410
19Basal cell carcinoma_Homo sapiens_hsa052171.49931229
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49788151
21Fatty acid biosynthesis_Homo sapiens_hsa000611.49741342
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41674943
23Galactose metabolism_Homo sapiens_hsa000521.36370688
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31952404
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29229801
26Fructose and mannose metabolism_Homo sapiens_hsa000511.28479390
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26671645
28Protein digestion and absorption_Homo sapiens_hsa049741.25965036
29Dilated cardiomyopathy_Homo sapiens_hsa054141.20949781
30Shigellosis_Homo sapiens_hsa051311.18043030
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17450393
32Thyroid cancer_Homo sapiens_hsa052161.16677180
33Toxoplasmosis_Homo sapiens_hsa051451.14365003
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13250605
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.11796526
36Hedgehog signaling pathway_Homo sapiens_hsa043401.10906584
37ErbB signaling pathway_Homo sapiens_hsa040121.10468819
38Viral carcinogenesis_Homo sapiens_hsa052031.09952192
39One carbon pool by folate_Homo sapiens_hsa006701.08488717
40Pathways in cancer_Homo sapiens_hsa052001.07054531
41Lysine degradation_Homo sapiens_hsa003101.05984522
42Viral myocarditis_Homo sapiens_hsa054161.05479825
43Melanoma_Homo sapiens_hsa052181.05381938
44Rap1 signaling pathway_Homo sapiens_hsa040151.05043485
45Arginine biosynthesis_Homo sapiens_hsa002201.03983135
46Prostate cancer_Homo sapiens_hsa052151.02342707
47Nitrogen metabolism_Homo sapiens_hsa009101.02083346
48Pancreatic cancer_Homo sapiens_hsa052121.00902647
49Pentose phosphate pathway_Homo sapiens_hsa000301.00840110
50mTOR signaling pathway_Homo sapiens_hsa041501.00782552
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00312663
52Endometrial cancer_Homo sapiens_hsa052131.00249868
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98936256
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97949335
55Insulin signaling pathway_Homo sapiens_hsa049100.94504770
56HTLV-I infection_Homo sapiens_hsa051660.92673194
57Steroid biosynthesis_Homo sapiens_hsa001000.89473318
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89296041
59Biosynthesis of amino acids_Homo sapiens_hsa012300.89124380
60Malaria_Homo sapiens_hsa051440.87743921
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.87147346
62Sphingolipid metabolism_Homo sapiens_hsa006000.84991507
63Notch signaling pathway_Homo sapiens_hsa043300.84866984
64Vitamin digestion and absorption_Homo sapiens_hsa049770.84501645
65TNF signaling pathway_Homo sapiens_hsa046680.84393910
66Phenylalanine metabolism_Homo sapiens_hsa003600.84362266
67Selenocompound metabolism_Homo sapiens_hsa004500.84127760
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82483746
69Apoptosis_Homo sapiens_hsa042100.81465074
70Complement and coagulation cascades_Homo sapiens_hsa046100.81427009
71Inositol phosphate metabolism_Homo sapiens_hsa005620.81308301
72Platelet activation_Homo sapiens_hsa046110.81021753
73HIF-1 signaling pathway_Homo sapiens_hsa040660.80826730
74Insulin resistance_Homo sapiens_hsa049310.80236578
75Glioma_Homo sapiens_hsa052140.79649728
76Renal cell carcinoma_Homo sapiens_hsa052110.78951774
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77021356
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.75934527
79Glucagon signaling pathway_Homo sapiens_hsa049220.75647713
80Vitamin B6 metabolism_Homo sapiens_hsa007500.75259390
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73324963
82Colorectal cancer_Homo sapiens_hsa052100.73280829
83Starch and sucrose metabolism_Homo sapiens_hsa005000.72633895
84VEGF signaling pathway_Homo sapiens_hsa043700.71528954
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70249652
86GnRH signaling pathway_Homo sapiens_hsa049120.67002729
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.66612647
88Wnt signaling pathway_Homo sapiens_hsa043100.65265296
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64590790
90Estrogen signaling pathway_Homo sapiens_hsa049150.63815939
91Dorso-ventral axis formation_Homo sapiens_hsa043200.61126729
92Choline metabolism in cancer_Homo sapiens_hsa052310.60131194
93Vibrio cholerae infection_Homo sapiens_hsa051100.59365520
94PPAR signaling pathway_Homo sapiens_hsa033200.59208919
95Hepatitis C_Homo sapiens_hsa051600.58838711
96Renin-angiotensin system_Homo sapiens_hsa046140.58570630
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.58420821
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58395555
99N-Glycan biosynthesis_Homo sapiens_hsa005100.57585582
100Hepatitis B_Homo sapiens_hsa051610.57019354
101Cell cycle_Homo sapiens_hsa041100.56685431
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56419202
103Systemic lupus erythematosus_Homo sapiens_hsa053220.56343143
104AMPK signaling pathway_Homo sapiens_hsa041520.56108178
105Non-small cell lung cancer_Homo sapiens_hsa052230.56059617
106Melanogenesis_Homo sapiens_hsa049160.55973778
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55403462
108Pertussis_Homo sapiens_hsa051330.54741764
109Histidine metabolism_Homo sapiens_hsa003400.54565057
110Leishmaniasis_Homo sapiens_hsa051400.54385027
111FoxO signaling pathway_Homo sapiens_hsa040680.54352744
112Thyroid hormone synthesis_Homo sapiens_hsa049180.54191520
113Acute myeloid leukemia_Homo sapiens_hsa052210.53502339
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53269156
115* Salmonella infection_Homo sapiens_hsa051320.51960181
116Prion diseases_Homo sapiens_hsa050200.51860942
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51749052
118Bile secretion_Homo sapiens_hsa049760.51680810
119Prolactin signaling pathway_Homo sapiens_hsa049170.50929384
120Staphylococcus aureus infection_Homo sapiens_hsa051500.50408434
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49979352
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49831909
123Type II diabetes mellitus_Homo sapiens_hsa049300.49423816
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48725934
125Caffeine metabolism_Homo sapiens_hsa002320.47770096
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47547535
127Antigen processing and presentation_Homo sapiens_hsa046120.46355122
128Other glycan degradation_Homo sapiens_hsa005110.46236670
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.45188501
130RNA transport_Homo sapiens_hsa030130.43608732
131Legionellosis_Homo sapiens_hsa051340.42573763
132Endocytosis_Homo sapiens_hsa041440.41968697
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40776875
134Axon guidance_Homo sapiens_hsa043600.40265786

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