FLII

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10512259
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10512259
3antigen processing and presentation of endogenous antigen (GO:0019883)4.73685613
4positive regulation of gamma-delta T cell activation (GO:0046645)4.32835419
5Golgi transport vesicle coating (GO:0048200)3.88584175
6COPI coating of Golgi vesicle (GO:0048205)3.88584175
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86743226
8regulation of gamma-delta T cell differentiation (GO:0045586)3.81339427
9positive regulation of histone deacetylation (GO:0031065)3.57674281
10hemidesmosome assembly (GO:0031581)3.54464409
11regulation of gamma-delta T cell activation (GO:0046643)3.49753602
12low-density lipoprotein particle clearance (GO:0034383)3.43150432
13regulation of interferon-beta biosynthetic process (GO:0045357)3.39989198
14positive regulation of Cdc42 GTPase activity (GO:0043089)3.39278482
15focal adhesion assembly (GO:0048041)3.36370296
16cell-substrate adherens junction assembly (GO:0007045)3.36370296
17apoptotic cell clearance (GO:0043277)3.31169486
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.26868952
19adherens junction assembly (GO:0034333)3.25253025
20regulation of cholesterol storage (GO:0010885)3.20883891
21stress fiber assembly (GO:0043149)3.15599562
22antigen processing and presentation via MHC class Ib (GO:0002475)3.09755338
23response to peptidoglycan (GO:0032494)3.09317780
24positive thymic T cell selection (GO:0045059)3.05667467
25modulation by symbiont of host defense response (GO:0052031)3.02956464
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02956464
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02956464
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.02956464
29modulation by symbiont of host immune response (GO:0052553)3.02956464
30positive regulation by symbiont of host defense response (GO:0052509)3.02956464
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.01753609
32regulation of early endosome to late endosome transport (GO:2000641)2.99989985
33skin morphogenesis (GO:0043589)2.99464848
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95422021
35negative regulation of erythrocyte differentiation (GO:0045647)2.95154330
36response to laminar fluid shear stress (GO:0034616)2.94656764
37positive regulation of natural killer cell differentiation (GO:0032825)2.88893722
38positive regulation of protein deacetylation (GO:0090312)2.88620517
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.88413412
40hypotonic response (GO:0006971)2.85649311
41positive regulation of interferon-alpha production (GO:0032727)2.85091951
42Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81680245
43activation of Rac GTPase activity (GO:0032863)2.80613214
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.80232264
45positive regulation of receptor recycling (GO:0001921)2.79916682
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75664552
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.75411175
48growth hormone receptor signaling pathway (GO:0060396)2.75122201
49negative regulation of necroptotic process (GO:0060546)2.74102892
50membrane raft organization (GO:0031579)2.73895348
51embryonic process involved in female pregnancy (GO:0060136)2.73330869
52epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73189530
53positive regulation of B cell differentiation (GO:0045579)2.72757418
54mannose metabolic process (GO:0006013)2.72592709
55plasma membrane repair (GO:0001778)2.71329458
56basement membrane organization (GO:0071711)2.71015053
57regulation of interferon-alpha production (GO:0032647)2.69838894
58cell adhesion mediated by integrin (GO:0033627)2.69597414
59regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66649391
60regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65730874
61regulation of necroptotic process (GO:0060544)2.64617817
62vascular endothelial growth factor signaling pathway (GO:0038084)2.63137733
63protein localization to endosome (GO:0036010)2.63081872
64macrophage activation involved in immune response (GO:0002281)2.62746654
65natural killer cell differentiation (GO:0001779)2.61229344
663-UTR-mediated mRNA stabilization (GO:0070935)2.60536001
67negative regulation of interleukin-12 production (GO:0032695)2.59199413
68regulation of B cell receptor signaling pathway (GO:0050855)2.57438222
69positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57340259
70positive regulation of p38MAPK cascade (GO:1900745)2.56790705
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55683174
72negative regulation of fatty acid transport (GO:2000192)2.55157543
73pinocytosis (GO:0006907)2.54321417
74NADPH regeneration (GO:0006740)2.53611260
75regulation of integrin activation (GO:0033623)2.49297062
76positive regulation of lamellipodium assembly (GO:0010592)2.48503159
77membrane protein ectodomain proteolysis (GO:0006509)2.47018727
78morphogenesis of an endothelium (GO:0003159)2.46484487
79endothelial tube morphogenesis (GO:0061154)2.46484487
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46138130
81negative regulation of cell killing (GO:0031342)2.46138130
82lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46130274
83cellular response to growth hormone stimulus (GO:0071378)2.45838378
84desmosome organization (GO:0002934)2.43153847
85hepatocyte apoptotic process (GO:0097284)2.42719955
86modulation by symbiont of host cellular process (GO:0044068)2.42420548
87glucose catabolic process (GO:0006007)2.42267504
88pentose-phosphate shunt (GO:0006098)2.42259754
89neutrophil activation involved in immune response (GO:0002283)2.42212251
90barbed-end actin filament capping (GO:0051016)2.42043953
91NIK/NF-kappaB signaling (GO:0038061)2.41734232
92thymic T cell selection (GO:0045061)2.41693539
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41216838
94immunoglobulin mediated immune response (GO:0016064)2.39754650
95cell-substrate junction assembly (GO:0007044)2.39549950
96regulation of leukocyte degranulation (GO:0043300)2.39115354
97positive regulation of lipid storage (GO:0010884)2.38865169
98regulation of response to interferon-gamma (GO:0060330)2.37829987
99response to muramyl dipeptide (GO:0032495)2.37171257
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36738189
101protein retention in ER lumen (GO:0006621)2.36300154
102leukocyte cell-cell adhesion (GO:0007159)2.35792826
103cortical actin cytoskeleton organization (GO:0030866)2.35088495
104response to interferon-alpha (GO:0035455)2.34332690
105negative regulation of cell size (GO:0045792)2.34212045
106negative regulation of phagocytosis (GO:0050765)2.34017714
107positive regulation of lamellipodium organization (GO:1902745)2.33384728
108regulation of necrotic cell death (GO:0010939)2.32475415
109establishment of endothelial barrier (GO:0061028)2.31995996
110epithelial cell-cell adhesion (GO:0090136)2.31926650
111regulation of macrophage cytokine production (GO:0010935)2.30047525
112regulation of B cell differentiation (GO:0045577)2.29506532
113cellular response to interferon-alpha (GO:0035457)2.29151216
114sarcomere organization (GO:0045214)2.28753740
115negative regulation of granulocyte differentiation (GO:0030853)2.28542085
116regulation of extracellular matrix disassembly (GO:0010715)2.26374932
117endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.26301527
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26244332
119negative regulation of stress fiber assembly (GO:0051497)2.26109250
120endodermal cell differentiation (GO:0035987)2.25767957
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.25407906
122germinal center formation (GO:0002467)2.25366973
123response to type I interferon (GO:0034340)2.25114032
124positive regulation of myotube differentiation (GO:0010831)2.24013827
125cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23349836
126maternal placenta development (GO:0001893)2.23089619
127platelet aggregation (GO:0070527)2.23009780
128leukocyte aggregation (GO:0070486)2.22134690
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.21637519
130response to fluid shear stress (GO:0034405)2.21290864
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.21174077
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.20758907
133response to host (GO:0075136)2.20758907
134response to host defenses (GO:0052200)2.20758907
135regulation of defense response to virus by virus (GO:0050690)2.20434468
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20396170
137negative regulation of protein localization to plasma membrane (GO:1903077)2.20194998
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.20146983
139apoptotic process involved in morphogenesis (GO:0060561)2.19546524
140detection of other organism (GO:0098543)2.19471694
141tricarboxylic acid metabolic process (GO:0072350)2.19323439
142regulation of tight junction assembly (GO:2000810)2.18927649
143tolerance induction (GO:0002507)2.18641250
144germ cell migration (GO:0008354)2.18625755
145B cell receptor signaling pathway (GO:0050853)2.17802974
146regulation of fatty acid beta-oxidation (GO:0031998)2.17782215
147valine metabolic process (GO:0006573)2.17763925
148negative regulation of viral release from host cell (GO:1902187)2.16856648
149glycosphingolipid catabolic process (GO:0046479)2.16535187
150glucose 6-phosphate metabolic process (GO:0051156)2.15958642
151regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.15364116
152positive regulation of nuclease activity (GO:0032075)2.15167326
153hyaluronan catabolic process (GO:0030214)2.15148929
154cellular response to thyroid hormone stimulus (GO:0097067)2.14666145
155regulation of superoxide anion generation (GO:0032928)2.13710241
156regulation of membrane protein ectodomain proteolysis (GO:0051043)2.12519231
157positive regulation of keratinocyte differentiation (GO:0045618)2.12260110
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.11550615
159cortical cytoskeleton organization (GO:0030865)2.11059120
160negative regulation of skeletal muscle tissue development (GO:0048642)2.09838836
161positive regulation of extracellular matrix organization (GO:1903055)2.09829770
162response to progesterone (GO:0032570)2.09577672
163positive regulation of endothelial cell apoptotic process (GO:2000353)2.09285914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52313897
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.37092138
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.06737729
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84879379
5MYC_22102868_ChIP-Seq_BL_Human2.79275964
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.78950238
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45591044
8VDR_21846776_ChIP-Seq_THP-1_Human2.44608334
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.44288391
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.34974933
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28596440
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24873172
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.19821050
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19124488
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17786004
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14287226
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12056405
18TCF7_22412390_ChIP-Seq_EML_Mouse2.09298896
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08650288
20MAF_26560356_Chip-Seq_TH1_Human2.06905233
21CLOCK_20551151_ChIP-Seq_293T_Human2.03578900
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.00194960
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93518408
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91718898
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90946473
26* KDM2B_26808549_Chip-Seq_DND41_Human1.89758235
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87959458
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81265883
29UTX_26944678_Chip-Seq_JUKART_Human1.79953721
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78222833
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.75979213
32VDR_24763502_ChIP-Seq_THP-1_Human1.73667175
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72061008
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70142928
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65894112
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65244242
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64732843
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63441803
39MYB_26560356_Chip-Seq_TH2_Human1.61008274
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60400699
41SPI1_23127762_ChIP-Seq_K562_Human1.60236268
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59783816
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59440768
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.57909172
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57087633
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56194172
47E2F7_22180533_ChIP-Seq_HELA_Human1.55599087
48LXR_22292898_ChIP-Seq_THP-1_Human1.53479902
49SCL_19346495_ChIP-Seq_HPC-7_Human1.50547690
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50384855
51MYB_26560356_Chip-Seq_TH1_Human1.47770549
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47516784
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46862396
54RACK7_27058665_Chip-Seq_MCF-7_Human1.46579112
55RUNX_20019798_ChIP-Seq_JUKART_Human1.45606425
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45243185
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.45214395
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44457660
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39221919
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37491240
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37334974
62* ATF3_27146783_Chip-Seq_COLON_Human1.37140322
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36963173
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34670946
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32726567
66GATA1_22025678_ChIP-Seq_K562_Human1.31762369
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31027490
68KDM2B_26808549_Chip-Seq_K562_Human1.30043878
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29256424
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29248768
71* SPI1_23547873_ChIP-Seq_NB4_Human1.27604889
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27551563
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27179344
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26895024
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26487946
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26293848
77NCOR1_26117541_ChIP-Seq_K562_Human1.26278440
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.24924557
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.24365507
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.23424268
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20416546
82MAF_26560356_Chip-Seq_TH2_Human1.19537325
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18964808
84GATA1_19941826_ChIP-Seq_K562_Human1.18177591
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18060794
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17709874
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.16650040
88TBX20_22080862_ChIP-Seq_HEART_Mouse1.16650040
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16524278
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16336750
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15830948
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15825036
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.14303032
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14040321
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.13986049
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13965868
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.13401854
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.12941082
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12702898
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.11645074
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11375727
102* TET1_21451524_ChIP-Seq_MESCs_Mouse1.09120148
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.08224789
104ZNF263_19887448_ChIP-Seq_K562_Human1.06792412
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06663505
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05788485
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.05343237
108* P68_20966046_ChIP-Seq_HELA_Human1.05184456
109TP53_22127205_ChIP-Seq_IMR90_Human1.05031868
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04417173
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04359841
112GATA3_27048872_Chip-Seq_THYMUS_Human1.03300702
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03021713
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02927453
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02138762
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02128656
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02111309
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01864849
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01864849
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01748035
121MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01628412
122PU_27001747_Chip-Seq_BMDM_Mouse1.00912838
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.00749200
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00229747
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99951555
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99350783
127SMC4_20622854_ChIP-Seq_HELA_Human0.99268497
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99229092
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99006940
130GATA6_25053715_ChIP-Seq_YYC3_Human0.98683229
131GATA2_19941826_ChIP-Seq_K562_Human0.98365803
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98323568
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97714014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.20169848
2MP0005451_abnormal_body_composition3.11653057
3MP0003303_peritoneal_inflammation2.63496666
4MP0003300_gastrointestinal_ulcer2.63342676
5MP0008438_abnormal_cutaneous_collagen2.48607156
6MP0003566_abnormal_cell_adhesion2.32959644
7MP0010352_gastrointestinal_tract_polyps2.21301168
8MP0008260_abnormal_autophagy2.19966180
9MP0001835_abnormal_antigen_presentation2.17618782
10MP0003436_decreased_susceptibility_to2.15422956
11MP0000685_abnormal_immune_system2.07942763
12MP0005058_abnormal_lysosome_morphology1.96004289
13MP0004233_abnormal_muscle_weight1.88930802
14MP0009840_abnormal_foam_cell1.85741990
15MP0004510_myositis1.77478717
16MP0009278_abnormal_bone_marrow1.73748042
17MP0003279_aneurysm1.69895359
18MP0005387_immune_system_phenotype1.69759864
19MP0001790_abnormal_immune_system1.69759864
20MP0004084_abnormal_cardiac_muscle1.69381854
21MP0005076_abnormal_cell_differentiation1.66290135
22MP0004947_skin_inflammation1.64351666
23MP0002166_altered_tumor_susceptibility1.63825171
24MP0002877_abnormal_melanocyte_morpholog1.61379462
25MP0001800_abnormal_humoral_immune1.61192349
26MP0005275_abnormal_skin_tensile1.59569600
27MP0004130_abnormal_muscle_cell1.57600382
28MP0002452_abnormal_antigen_presenting1.55423975
29MP0005464_abnormal_platelet_physiology1.55360290
30MP0002419_abnormal_innate_immunity1.55097115
31MP0006054_spinal_hemorrhage1.54263031
32MP0004272_abnormal_basement_membrane1.53047541
33MP0001958_emphysema1.51948985
34MP0009785_altered_susceptibility_to1.50385426
35MP0004858_abnormal_nervous_system1.47334716
36MP0005025_abnormal_response_to1.47290984
37MP0005000_abnormal_immune_tolerance1.46599194
38* MP0005023_abnormal_wound_healing1.45774961
39MP0004808_abnormal_hematopoietic_stem1.43377305
40MP0002796_impaired_skin_barrier1.43253163
41MP0003191_abnormal_cellular_cholesterol1.41755130
42MP0010155_abnormal_intestine_physiology1.40814191
43MP0003091_abnormal_cell_migration1.37883987
44MP0004185_abnormal_adipocyte_glucose1.36605181
45MP0001533_abnormal_skeleton_physiology1.35703199
46MP0001819_abnormal_immune_cell1.33869434
47MP0002420_abnormal_adaptive_immunity1.33841365
48MP0002723_abnormal_immune_serum1.33783223
49MP0003950_abnormal_plasma_membrane1.32785479
50MP0001873_stomach_inflammation1.32463080
51MP0000343_altered_response_to1.32143604
52MP0000747_muscle_weakness1.28601102
53MP0006082_CNS_inflammation1.27841905
54MP0005257_abnormal_intraocular_pressure1.26835156
55MP0003045_fibrosis1.26213807
56MP0000759_abnormal_skeletal_muscle1.26147233
57MP0005671_abnormal_response_to1.25878309
58MP0005409_darkened_coat_color1.25417026
59MP0002405_respiratory_system_inflammati1.24918215
60MP0002396_abnormal_hematopoietic_system1.24873659
61MP0000733_abnormal_muscle_development1.24151352
62MP0000750_abnormal_muscle_regeneration1.24009956
63MP0009333_abnormal_splenocyte_physiolog1.22918681
64MP0005397_hematopoietic_system_phenotyp1.22726393
65MP0001545_abnormal_hematopoietic_system1.22726393
66MP0002398_abnormal_bone_marrow1.22090274
67MP0003172_abnormal_lysosome_physiology1.21787091
68MP0010630_abnormal_cardiac_muscle1.21318835
69MP0005666_abnormal_adipose_tissue1.20343971
70MP0004087_abnormal_muscle_fiber1.19762341
71MP0005670_abnormal_white_adipose1.17778055
72MP0003828_pulmonary_edema1.16332045
73MP0010307_abnormal_tumor_latency1.14278207
74MP0002006_tumorigenesis1.14054021
75MP0000003_abnormal_adipose_tissue1.13604996
76MP0003448_altered_tumor_morphology1.13140522
77MP0001845_abnormal_inflammatory_respons1.13052502
78MP0000858_altered_metastatic_potential1.12433134
79MP0003763_abnormal_thymus_physiology1.11804505
80MP0000716_abnormal_immune_system1.11799007
81MP0003724_increased_susceptibility_to1.11252495
82MP0005501_abnormal_skin_physiology1.09657779
83MP0002148_abnormal_hypersensitivity_rea1.09599428
84MP0001853_heart_inflammation1.07424613
85MP0000767_abnormal_smooth_muscle1.07041869
86MP0010234_abnormal_vibrissa_follicle1.05992979
87MP0002722_abnormal_immune_system1.04657520
88MP0000689_abnormal_spleen_morphology1.04652017
89MP0002837_dystrophic_cardiac_calcinosis1.03576810
90MP0002933_joint_inflammation1.02715416
91MP0002332_abnormal_exercise_endurance1.02038731
92MP0004264_abnormal_extraembryonic_tissu1.01721924
93MP0002429_abnormal_blood_cell0.99625896
94MP0005375_adipose_tissue_phenotype0.99530758
95MP0003075_altered_response_to0.99177489
96MP0000751_myopathy0.98743768
97MP0002254_reproductive_system_inflammat0.98676297
98MP0005623_abnormal_meninges_morphology0.97911662
99MP0004036_abnormal_muscle_relaxation0.96171512
100MP0001216_abnormal_epidermal_layer0.95869858
101MP0005330_cardiomyopathy0.95528840
102MP0001849_ear_inflammation0.94530848
103MP0000749_muscle_degeneration0.92976972
104MP0005621_abnormal_cell_physiology0.92854199
105MP0000465_gastrointestinal_hemorrhage0.92773427
106MP0002269_muscular_atrophy0.91958773
107MP0008961_abnormal_basal_metabolism0.91879433
108MP0001348_abnormal_lacrimal_gland0.91665417
109MP0005165_increased_susceptibility_to0.91031638
110MP0008469_abnormal_protein_level0.90218564
111MP0002998_abnormal_bone_remodeling0.90109038
112MP0000249_abnormal_blood_vessel0.89797221
113MP0001851_eye_inflammation0.86802074
114MP0001915_intracranial_hemorrhage0.86605414
115MP0000490_abnormal_crypts_of0.86071471
116MP0001544_abnormal_cardiovascular_syste0.85935541
117MP0005385_cardiovascular_system_phenoty0.85935541
118MP0003866_abnormal_defecation0.85680604
119MP0003329_amyloid_beta_deposits0.85274950
120MP0002060_abnormal_skin_morphology0.84718518
121MP0000609_abnormal_liver_physiology0.84429580
122MP0008775_abnormal_heart_ventricle0.83423970
123MP0006138_congestive_heart_failure0.83017990
124MP0000678_abnormal_parathyroid_gland0.82965386
125MP0003221_abnormal_cardiomyocyte_apopto0.82607902
126MP0003453_abnormal_keratinocyte_physiol0.82569594
127MP0001879_abnormal_lymphatic_vessel0.82436018
128MP0002896_abnormal_bone_mineralization0.81432267
129MP0010368_abnormal_lymphatic_system0.81241640
130MP0002128_abnormal_blood_circulation0.81043258
131MP0000013_abnormal_adipose_tissue0.79865362
132MP0003656_abnormal_erythrocyte_physiolo0.77339718
133MP0001243_abnormal_dermal_layer0.75943517
134MP0009931_abnormal_skin_appearance0.73605980

Predicted human phenotypes

RankGene SetZ-score
1Distal lower limb amyotrophy (HP:0008944)3.62664557
2Cerebral aneurysm (HP:0004944)3.58543579
3Distal lower limb muscle weakness (HP:0009053)3.58351512
4Aortic aneurysm (HP:0004942)3.38923962
5Eczematoid dermatitis (HP:0000976)3.32534147
6Increased connective tissue (HP:0009025)3.22963299
7Centrally nucleated skeletal muscle fibers (HP:0003687)3.16269500
8Protrusio acetabuli (HP:0003179)3.13129041
9Exercise-induced myalgia (HP:0003738)3.03681355
10Nemaline bodies (HP:0003798)2.94342182
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.92698021
12Broad face (HP:0000283)2.90146912
13Muscle fiber inclusion bodies (HP:0100299)2.89388961
14Recurrent abscess formation (HP:0002722)2.77350539
15Abnormality of the nasal mucosa (HP:0000433)2.71994316
16Increased variability in muscle fiber diameter (HP:0003557)2.71395238
17Interstitial pulmonary disease (HP:0006530)2.65021763
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.62571663
19Osteolytic defects of the hand bones (HP:0009699)2.62571663
20Increased density of long bones (HP:0006392)2.62357027
21Hematochezia (HP:0002573)2.57452871
22Spinal rigidity (HP:0003306)2.55579072
23Nasal polyposis (HP:0100582)2.53563211
24Cellulitis (HP:0100658)2.51798698
25Aneurysm (HP:0002617)2.50996765
26Asymmetric septal hypertrophy (HP:0001670)2.50306347
27Achilles tendon contracture (HP:0001771)2.48267889
28Lower limb amyotrophy (HP:0007210)2.46486215
29Aortic dissection (HP:0002647)2.46408301
30Recurrent bacterial skin infections (HP:0005406)2.46358239
31Right ventricular cardiomyopathy (HP:0011663)2.45523796
32Ankle contracture (HP:0006466)2.45423131
33Autoimmune thrombocytopenia (HP:0001973)2.45249830
34Cervical subluxation (HP:0003308)2.44420952
35Peritonitis (HP:0002586)2.38531232
36Frequent falls (HP:0002359)2.38466601
37Premature rupture of membranes (HP:0001788)2.38057200
38Broad metatarsal (HP:0001783)2.37148171
39Myocardial infarction (HP:0001658)2.36696035
40Increased cerebral lipofuscin (HP:0011813)2.36266279
41Short nail (HP:0001799)2.34282662
42Myopathic facies (HP:0002058)2.33535270
43Hyporeflexia of lower limbs (HP:0002600)2.33342530
44Atrophic scars (HP:0001075)2.30702015
45Spontaneous hematomas (HP:0007420)2.30347381
46Recurrent viral infections (HP:0004429)2.28246306
47Facial diplegia (HP:0001349)2.27391223
48Mitral valve prolapse (HP:0001634)2.27075372
49Type 1 muscle fiber predominance (HP:0003803)2.25825656
50Recurrent fungal infections (HP:0002841)2.25585443
51Abnormality of the Achilles tendon (HP:0005109)2.21582466
52Dilatation of the ascending aorta (HP:0005111)2.20868837
53Abnormality of liposaccharide metabolism (HP:0010968)2.20784365
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.20784365
55Abnormality of glycolipid metabolism (HP:0010969)2.20784365
56Recurrent gram-negative bacterial infections (HP:0005420)2.20552786
57Fragile skin (HP:0001030)2.19593741
58Distal upper limb amyotrophy (HP:0007149)2.18347714
59Upper limb amyotrophy (HP:0009129)2.18347714
60Difficulty climbing stairs (HP:0003551)2.16961653
61Polycythemia (HP:0001901)2.15921374
62Pustule (HP:0200039)2.15448314
63Difficulty running (HP:0009046)2.15108939
64Colitis (HP:0002583)2.14371040
65Ventricular tachycardia (HP:0004756)2.13695723
66Myositis (HP:0100614)2.11589761
67Ulnar bowing (HP:0003031)2.08371481
68Gastrointestinal inflammation (HP:0004386)2.08146370
69Shallow orbits (HP:0000586)2.07379096
70Inflammation of the large intestine (HP:0002037)2.06208387
71Chronic otitis media (HP:0000389)2.05131919
72Muscle fiber splitting (HP:0003555)2.03674458
73Abnormal platelet volume (HP:0011876)2.03081627
74Abnormality of macrophages (HP:0004311)2.02805583
75Hand muscle atrophy (HP:0009130)2.00686912
76Spondylolisthesis (HP:0003302)1.97007901
77Dysostosis multiplex (HP:0000943)1.96839808
78Striae distensae (HP:0001065)1.96472097
79Elevated erythrocyte sedimentation rate (HP:0003565)1.95957155
80Abnormality of the distal phalanges of the toes (HP:0010182)1.95746744
81Increased mean platelet volume (HP:0011877)1.94439247
82Ulnar deviation of the wrist (HP:0003049)1.93182005
83Emphysema (HP:0002097)1.90254177
84Vertebral compression fractures (HP:0002953)1.90179710
85Generalized amyotrophy (HP:0003700)1.89686463
86Thin bony cortex (HP:0002753)1.88788090
87Esophageal varix (HP:0002040)1.88724387
88Systemic lupus erythematosus (HP:0002725)1.87851804
89Axonal loss (HP:0003447)1.87726224
90Arterial tortuosity (HP:0005116)1.86406518
91Exercise-induced muscle cramps (HP:0003710)1.86171664
92Arterial thrombosis (HP:0004420)1.85332076
93Neck muscle weakness (HP:0000467)1.84153557
94Papilloma (HP:0012740)1.84035817
95Verrucae (HP:0200043)1.84035817
96Scapular winging (HP:0003691)1.83701630
97Abnormality of skeletal muscle fiber size (HP:0012084)1.82606493
98Vacuolated lymphocytes (HP:0001922)1.82416971
99Fatigue (HP:0012378)1.82319654
100Long toe (HP:0010511)1.82246018
101Myoglobinuria (HP:0002913)1.81821277
102Amyloidosis (HP:0011034)1.80095637
103Abnormality of the fingertips (HP:0001211)1.79611163
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.78915378
105Vascular tortuosity (HP:0004948)1.78752694
106Bulbar palsy (HP:0001283)1.77597465
107Radial bowing (HP:0002986)1.77269842
108Wormian bones (HP:0002645)1.77073262
109Mucopolysacchariduria (HP:0008155)1.76386535
110Urinary glycosaminoglycan excretion (HP:0003541)1.76386535
111Round ear (HP:0100830)1.76309663
112Mitral regurgitation (HP:0001653)1.76301106
113Bicuspid aortic valve (HP:0001647)1.76290821
114Persistence of primary teeth (HP:0006335)1.76271624
115Gingivitis (HP:0000230)1.74862617
116Mildly elevated creatine phosphokinase (HP:0008180)1.74320981
117Lipoatrophy (HP:0100578)1.74155388
118Trismus (HP:0000211)1.73755622
119Abnormal platelet function (HP:0011869)1.73604192
120Impaired platelet aggregation (HP:0003540)1.73604192
121Blue sclerae (HP:0000592)1.73396912
122Rhabdomyolysis (HP:0003201)1.73361209
123Periodontitis (HP:0000704)1.72208522
124Sudden death (HP:0001699)1.71287617
125Increased IgE level (HP:0003212)1.70364111
126Recurrent bronchitis (HP:0002837)1.69907481
127Natal tooth (HP:0000695)1.69520598
128Disproportionate tall stature (HP:0001519)1.69358259
129Cerebral inclusion bodies (HP:0100314)1.68352278
130Chest pain (HP:0100749)1.67841737
131EMG: myopathic abnormalities (HP:0003458)1.66856005
132Stridor (HP:0010307)1.66407642
133Loss of speech (HP:0002371)1.66357296
134Recurrent skin infections (HP:0001581)1.66312738
135Thrombocytosis (HP:0001894)1.66200440
136Bladder diverticulum (HP:0000015)1.65860611
137Nuclear cataract (HP:0100018)1.65804415
138Osteomyelitis (HP:0002754)1.65179865
139Flat acetabular roof (HP:0003180)1.64957087
140Abnormality of polysaccharide metabolism (HP:0011012)1.63484605
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63484605
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63484605
143Back pain (HP:0003418)1.63381524
144Abnormality of oral frenula (HP:0000190)1.62658802
145Muscle stiffness (HP:0003552)1.62543396
146Easy fatigability (HP:0003388)1.61036484
147Thick nail (HP:0001805)1.60924653
148Long palpebral fissure (HP:0000637)1.60263887
149Spinal cord lesions (HP:0100561)1.58985898
150Syringomyelia (HP:0003396)1.58985898
151Slender build (HP:0001533)1.58958095
152Ragged-red muscle fibers (HP:0003200)1.58567627
153Elbow flexion contracture (HP:0002987)1.58176802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.25810797
2TTN3.58059104
3PKN23.50858711
4ERN13.12926471
5MAP4K12.98891233
6SMG12.89898317
7PRPF4B2.83344879
8IRAK32.78675038
9EEF2K2.71407688
10MAP3K102.22988436
11ICK2.22455417
12STK102.13171726
13LRRK22.02084284
14TYK21.91874016
15PTK61.86716897
16JAK31.86314395
17TGFBR21.82970959
18MAP2K31.79937706
19RIPK11.79397010
20TBK11.77310770
21FGFR41.75606167
22EPHB11.67939250
23MAP3K131.64081398
24SIK11.63303479
25NME21.62540205
26JAK11.54685318
27ZAP701.45009233
28TESK11.43918291
29TAOK21.40394540
30FLT31.34784564
31PDGFRA1.31942178
32KIT1.31793011
33DMPK1.27117385
34CDK121.24309789
35CAMK1D1.21021815
36CSK1.19500401
37MOS1.18209839
38TESK21.12559134
39FGFR31.11725575
40NEK91.08856593
41MAP3K61.05805810
42CDC42BPA1.04255269
43ITK1.03870531
44MAP3K11.02911109
45CSF1R1.02685848
46BTK1.01908886
47RIPK41.01510018
48MET1.00633950
49HCK1.00523028
50TRPM71.00449357
51MAP3K71.00288006
52MAP3K140.99833467
53IRAK40.99074308
54BMX0.99069169
55PAK40.98771790
56GRK60.97764524
57RPS6KA40.96171596
58KSR20.94483072
59PRKD20.93922416
60ARAF0.93118333
61BLK0.92973921
62LMTK20.89269460
63EPHA30.88209684
64KDR0.88131838
65MAP3K30.87189906
66SCYL20.86006545
67TAOK30.85270649
68PRKG20.84871972
69JAK20.81902275
70SIK30.81518937
71LATS20.80723495
72CDK60.79662800
73MTOR0.79502330
74PIM10.77885037
75MARK20.75674258
76IKBKE0.75197270
77PDPK10.74813395
78PDGFRB0.74489773
79MARK30.73771130
80TAOK10.73766640
81CDK40.72628436
82TGFBR10.70961060
83IKBKB0.70839412
84CHUK0.67451470
85PAK20.67104564
86LIMK10.66564262
87ALK0.66281654
88PTK20.66121330
89MAP3K80.66080050
90MATK0.65744882
91CAMK1G0.65510596
92MAPKAPK30.65125797
93SYK0.64610618
94LCK0.64380114
95OBSCN0.64171572
96RPS6KB20.63650240
97RET0.63277186
98NEK20.63272252
99IRAK20.62357672
100STK40.62208953
101NTRK10.60920502
102ILK0.59061888
103FGR0.58496414
104STK380.58020330
105STK30.57927914
106DYRK1B0.57150259
107MYLK0.55951485
108MAP3K110.55422494
109PRKD10.55057097
110SIK20.54543347
111MAPK120.54125054
112PRKCH0.53563231
113EPHA20.53326881
114NEK10.52357109
115TXK0.51914377
116MAPK110.51582454
117TIE10.50382144
118DDR20.50208018
119PIM20.50054601
120MAPKAPK20.49044947
121PIK3CG0.46190384
122HIPK20.43712987
123RPS6KA60.42727499
124EGFR0.41887579
125TEC0.41433461
126MST1R0.41120252
127PRKAA20.41044196
128MAPK70.40490979
129ERBB40.40444812
130RPS6KL10.40029547
131RPS6KC10.40029547
132PDK10.38522735
133CDK90.36064136
134MAP2K20.35559022
135CDK70.35396589
136STK240.33752234
137RPS6KA20.33178629
138MELK0.32977080

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.24534081
2Osteoclast differentiation_Homo sapiens_hsa043801.98813832
3B cell receptor signaling pathway_Homo sapiens_hsa046621.94271772
4Viral myocarditis_Homo sapiens_hsa054161.81405329
5Toxoplasmosis_Homo sapiens_hsa051451.76192795
6Chronic myeloid leukemia_Homo sapiens_hsa052201.76052978
7Caffeine metabolism_Homo sapiens_hsa002321.75960390
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.72627858
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69939049
10Staphylococcus aureus infection_Homo sapiens_hsa051501.67600490
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.58197399
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55201522
13Antigen processing and presentation_Homo sapiens_hsa046121.55114574
14Acute myeloid leukemia_Homo sapiens_hsa052211.50485091
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50482431
16Measles_Homo sapiens_hsa051621.47681470
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45495313
18Insulin resistance_Homo sapiens_hsa049311.41516600
19Focal adhesion_Homo sapiens_hsa045101.41351612
20Primary immunodeficiency_Homo sapiens_hsa053401.40391763
21Apoptosis_Homo sapiens_hsa042101.37669057
22Shigellosis_Homo sapiens_hsa051311.36872040
23Small cell lung cancer_Homo sapiens_hsa052221.36366380
24Fructose and mannose metabolism_Homo sapiens_hsa000511.36207763
25Thyroid cancer_Homo sapiens_hsa052161.36195019
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.35770978
27Platelet activation_Homo sapiens_hsa046111.33602813
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28867093
29Lysosome_Homo sapiens_hsa041421.28008777
30Amoebiasis_Homo sapiens_hsa051461.27870629
31Legionellosis_Homo sapiens_hsa051341.27236354
32Proteoglycans in cancer_Homo sapiens_hsa052051.26022163
33Malaria_Homo sapiens_hsa051441.25651577
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24785910
35Other glycan degradation_Homo sapiens_hsa005111.24196041
36Tuberculosis_Homo sapiens_hsa051521.23124621
37Pancreatic cancer_Homo sapiens_hsa052121.23030173
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.21749255
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21412552
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.19965377
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19581056
42TNF signaling pathway_Homo sapiens_hsa046681.19044175
43Pertussis_Homo sapiens_hsa051331.17401048
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15488635
45Salmonella infection_Homo sapiens_hsa051321.13364505
46Influenza A_Homo sapiens_hsa051641.10665682
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09130725
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08773563
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08572699
50Adherens junction_Homo sapiens_hsa045201.04940304
51ECM-receptor interaction_Homo sapiens_hsa045121.04818985
52T cell receptor signaling pathway_Homo sapiens_hsa046601.04616769
53Prion diseases_Homo sapiens_hsa050201.03712517
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.01004897
55Hepatitis B_Homo sapiens_hsa051611.00826434
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00681929
57Dilated cardiomyopathy_Homo sapiens_hsa054140.99889266
58Fatty acid degradation_Homo sapiens_hsa000710.99304498
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.99156045
60Hematopoietic cell lineage_Homo sapiens_hsa046400.98849584
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95531999
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94728071
63Lysine degradation_Homo sapiens_hsa003100.94157983
64VEGF signaling pathway_Homo sapiens_hsa043700.93719277
65HIF-1 signaling pathway_Homo sapiens_hsa040660.92065801
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89354440
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.88948505
68Chemokine signaling pathway_Homo sapiens_hsa040620.87017029
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86762652
70mTOR signaling pathway_Homo sapiens_hsa041500.86648102
71GnRH signaling pathway_Homo sapiens_hsa049120.85986347
72Non-small cell lung cancer_Homo sapiens_hsa052230.85445680
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85214047
74Notch signaling pathway_Homo sapiens_hsa043300.84770150
75Herpes simplex infection_Homo sapiens_hsa051680.84752631
76PPAR signaling pathway_Homo sapiens_hsa033200.84483460
77Glioma_Homo sapiens_hsa052140.84234141
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83176931
79Viral carcinogenesis_Homo sapiens_hsa052030.83076438
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81832621
81Insulin signaling pathway_Homo sapiens_hsa049100.81814690
82Prostate cancer_Homo sapiens_hsa052150.80021912
83Hepatitis C_Homo sapiens_hsa051600.79738331
84MicroRNAs in cancer_Homo sapiens_hsa052060.79311831
85Prolactin signaling pathway_Homo sapiens_hsa049170.79199932
86Bladder cancer_Homo sapiens_hsa052190.78808571
87HTLV-I infection_Homo sapiens_hsa051660.77847584
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77660832
89ErbB signaling pathway_Homo sapiens_hsa040120.76389266
90Biosynthesis of amino acids_Homo sapiens_hsa012300.76306415
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.71533748
92AMPK signaling pathway_Homo sapiens_hsa041520.71189800
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69649857
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.69216621
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68794034
96Inositol phosphate metabolism_Homo sapiens_hsa005620.67930619
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64504737
98Colorectal cancer_Homo sapiens_hsa052100.62056775
99Endocytosis_Homo sapiens_hsa041440.61987195
100Renal cell carcinoma_Homo sapiens_hsa052110.61072006
101Pentose phosphate pathway_Homo sapiens_hsa000300.61029339
102Carbon metabolism_Homo sapiens_hsa012000.60800210
103Renin-angiotensin system_Homo sapiens_hsa046140.59791254
104Complement and coagulation cascades_Homo sapiens_hsa046100.59718173
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59121634
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58876711
107FoxO signaling pathway_Homo sapiens_hsa040680.58644447
108Galactose metabolism_Homo sapiens_hsa000520.57123699
109Estrogen signaling pathway_Homo sapiens_hsa049150.56628797
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56543166
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55561919
112Vibrio cholerae infection_Homo sapiens_hsa051100.54600851
113Fatty acid metabolism_Homo sapiens_hsa012120.54353219
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53382769
115Endometrial cancer_Homo sapiens_hsa052130.49459650
116Phagosome_Homo sapiens_hsa041450.49407387
117Starch and sucrose metabolism_Homo sapiens_hsa005000.48780486
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46947711

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »