FKBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36518836
2negative regulation of cell killing (GO:0031342)6.36518836
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.03841269
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.75095703
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.55734252
6L-phenylalanine metabolic process (GO:0006558)5.55734252
7antigen processing and presentation of endogenous antigen (GO:0019883)5.42713656
8L-phenylalanine catabolic process (GO:0006559)5.38591845
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.38591845
10positive regulation by symbiont of host defense response (GO:0052509)5.23642005
11modulation by symbiont of host defense response (GO:0052031)5.23642005
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.23642005
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.23642005
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.23642005
15modulation by symbiont of host immune response (GO:0052553)5.23642005
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.13888057
17alpha-linolenic acid metabolic process (GO:0036109)5.13792674
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.03543833
19detection of bacterium (GO:0016045)4.85179411
20detection of other organism (GO:0098543)4.84098536
21neutrophil activation involved in immune response (GO:0002283)4.78746567
22positive regulation of gamma-delta T cell activation (GO:0046645)4.77423482
23kynurenine metabolic process (GO:0070189)4.65766428
24aromatic amino acid family catabolic process (GO:0009074)4.64393971
25lysine catabolic process (GO:0006554)4.57784589
26lysine metabolic process (GO:0006553)4.57784589
27sulfur amino acid catabolic process (GO:0000098)4.51060477
28negative regulation of fibrinolysis (GO:0051918)4.40427600
29high-density lipoprotein particle remodeling (GO:0034375)4.37919146
30bile acid biosynthetic process (GO:0006699)4.37475923
31urea metabolic process (GO:0019627)4.35794008
32urea cycle (GO:0000050)4.35794008
33glyoxylate metabolic process (GO:0046487)4.35633893
34leukocyte aggregation (GO:0070486)4.34548833
35macrophage activation involved in immune response (GO:0002281)4.29774815
36negative regulation of cholesterol transport (GO:0032375)4.25914093
37negative regulation of sterol transport (GO:0032372)4.25914093
38cysteine metabolic process (GO:0006534)4.25836601
39dicarboxylic acid biosynthetic process (GO:0043650)4.18672898
40regulation of cholesterol homeostasis (GO:2000188)4.16975490
41regulation of B cell receptor signaling pathway (GO:0050855)4.16918194
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.11492014
43tryptophan catabolic process (GO:0006569)4.04501491
44indole-containing compound catabolic process (GO:0042436)4.04501491
45indolalkylamine catabolic process (GO:0046218)4.04501491
46negative regulation of erythrocyte differentiation (GO:0045647)4.03315000
47negative regulation of lymphocyte mediated immunity (GO:0002707)4.01556733
48glutamate metabolic process (GO:0006536)3.99974382
49nitrogen cycle metabolic process (GO:0071941)3.99306233
50response to peptidoglycan (GO:0032494)3.98210871
51regulation of cholesterol esterification (GO:0010872)3.97971486
52detection of external biotic stimulus (GO:0098581)3.94473697
53complement activation, alternative pathway (GO:0006957)3.92914712
54cellular modified amino acid catabolic process (GO:0042219)3.89849789
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.89350640
56regulation of protein activation cascade (GO:2000257)3.87587047
57response to interleukin-15 (GO:0070672)3.85421081
58phospholipid efflux (GO:0033700)3.85366944
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83499636
60reverse cholesterol transport (GO:0043691)3.83046176
61peptidyl-glutamic acid carboxylation (GO:0017187)3.81343009
62protein carboxylation (GO:0018214)3.81343009
63regulation of fibrinolysis (GO:0051917)3.77769515
64serine family amino acid catabolic process (GO:0009071)3.77578207
65oxygen transport (GO:0015671)3.76115730
66respiratory burst (GO:0045730)3.75252700
67negative regulation of leukocyte mediated immunity (GO:0002704)3.74171168
68negative regulation of phagocytosis (GO:0050765)3.71560610
69bile acid metabolic process (GO:0008206)3.70376456
702-oxoglutarate metabolic process (GO:0006103)3.67902775
71leukocyte migration involved in inflammatory response (GO:0002523)3.67118976
72tryptophan metabolic process (GO:0006568)3.63963087
73regulation of fatty acid beta-oxidation (GO:0031998)3.63836204
74regulation of complement activation (GO:0030449)3.63458073
75regulation of triglyceride catabolic process (GO:0010896)3.61055743
76plasma lipoprotein particle remodeling (GO:0034369)3.59364954
77protein-lipid complex remodeling (GO:0034368)3.59364954
78macromolecular complex remodeling (GO:0034367)3.59364954
79homocysteine metabolic process (GO:0050667)3.56854357
80neutrophil activation (GO:0042119)3.56242530
81amino-acid betaine metabolic process (GO:0006577)3.56056699
82alpha-amino acid catabolic process (GO:1901606)3.53359113
83regulation of mast cell degranulation (GO:0043304)3.53304753
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50417109
85plasma lipoprotein particle clearance (GO:0034381)3.49998932
86negative regulation of interleukin-12 production (GO:0032695)3.49279254
87plasma lipoprotein particle assembly (GO:0034377)3.47559444
88glycine metabolic process (GO:0006544)3.47292344
89response to host immune response (GO:0052572)3.45603000
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45603000
91regulation of leukocyte degranulation (GO:0043300)3.44817151
92aspartate family amino acid catabolic process (GO:0009068)3.44683830
93cellular response to interleukin-15 (GO:0071350)3.43558082
94regulation of gamma-delta T cell activation (GO:0046643)3.43176582
95ethanol oxidation (GO:0006069)3.41726280
96detection of biotic stimulus (GO:0009595)3.39431546
97cellular amino acid catabolic process (GO:0009063)3.37764076
98regulation of interferon-beta biosynthetic process (GO:0045357)3.37315247
99protein-lipid complex assembly (GO:0065005)3.36832916
100regulation of T-helper 2 cell differentiation (GO:0045628)3.34280802
101detection of molecule of bacterial origin (GO:0032490)3.33301044
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33084466
103aromatic amino acid family metabolic process (GO:0009072)3.31697125
104cellular ketone body metabolic process (GO:0046950)3.31004578
105cellular extravasation (GO:0045123)3.29423751
106positive regulation of triglyceride metabolic process (GO:0090208)3.28785328
107cholesterol efflux (GO:0033344)3.28606462
108positive regulation of triglyceride biosynthetic process (GO:0010867)3.27687203
109granulocyte activation (GO:0036230)3.26979648
110positive regulation of lipid catabolic process (GO:0050996)3.26612861
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25869966
112response to host (GO:0075136)3.25869966
113response to host defenses (GO:0052200)3.25869966
114positive regulation of fatty acid beta-oxidation (GO:0032000)3.25472608
115drug catabolic process (GO:0042737)3.23318011
116triglyceride homeostasis (GO:0070328)3.22833527
117acylglycerol homeostasis (GO:0055090)3.22833527
118serine family amino acid metabolic process (GO:0009069)3.22692269
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.21712426
120regulation of regulated secretory pathway (GO:1903305)3.20451955
121immunoglobulin mediated immune response (GO:0016064)3.19334710
122myeloid cell activation involved in immune response (GO:0002275)3.17949296
123cellular response to type I interferon (GO:0071357)3.16653853
124type I interferon signaling pathway (GO:0060337)3.16653853
125regulation of mast cell activation involved in immune response (GO:0033006)3.16211703
126signal complex assembly (GO:0007172)3.15207724
127response to type I interferon (GO:0034340)3.14746120
128gas transport (GO:0015669)3.10825284
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10685314
130coenzyme catabolic process (GO:0009109)3.09664619
131antigen processing and presentation via MHC class Ib (GO:0002475)3.09379022
132positive thymic T cell selection (GO:0045059)3.08958502
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07382007
134serine family amino acid biosynthetic process (GO:0009070)3.06642094
135regulation of gamma-delta T cell differentiation (GO:0045586)3.06129474
136B cell receptor signaling pathway (GO:0050853)3.05192292
137negative regulation of T cell mediated immunity (GO:0002710)3.04088931
138oxaloacetate metabolic process (GO:0006107)3.03521084
139microglial cell activation (GO:0001774)3.01149354
140acetyl-CoA metabolic process (GO:0006084)3.01121053
141macrophage activation (GO:0042116)3.00639608
142dicarboxylic acid catabolic process (GO:0043649)3.00295172
143germinal center formation (GO:0002467)2.99646322
144regulation of T cell tolerance induction (GO:0002664)2.99406810
145negative regulation of type 2 immune response (GO:0002829)2.99248664
146benzene-containing compound metabolic process (GO:0042537)2.98484533
147cholesterol catabolic process (GO:0006707)2.98016899
148sterol catabolic process (GO:0016127)2.98016899
149valine metabolic process (GO:0006573)2.95718537
150neutrophil mediated immunity (GO:0002446)2.95670333
151positive regulation of triglyceride lipase activity (GO:0061365)2.94418958
152positive regulation of lipoprotein lipase activity (GO:0051006)2.94418958
153response to muramyl dipeptide (GO:0032495)2.93675388
154modulation by virus of host process (GO:0019054)2.93208969
155arginine metabolic process (GO:0006525)2.93166043
156regulation of cholesterol biosynthetic process (GO:0045540)2.92736601
157tricarboxylic acid metabolic process (GO:0072350)2.92732895
158phospholipid homeostasis (GO:0055091)2.92693833
159exogenous drug catabolic process (GO:0042738)2.92582587
160bile acid and bile salt transport (GO:0015721)2.90416653
161short-chain fatty acid metabolic process (GO:0046459)2.89600747
162negative regulation of cell size (GO:0045792)2.89398399
163leukocyte degranulation (GO:0043299)2.88577755
164negative regulation of lipid transport (GO:0032369)2.88567014
165plasma lipoprotein particle organization (GO:0071827)2.87195201
166regulation of platelet aggregation (GO:0090330)2.86761515
167glutamine family amino acid biosynthetic process (GO:0009084)2.86473415
168tyrosine metabolic process (GO:0006570)2.86413442
169protein-lipid complex subunit organization (GO:0071825)2.84861362
170carboxylic acid catabolic process (GO:0046395)2.84779457
171organic acid catabolic process (GO:0016054)2.84779457
172ketone body metabolic process (GO:1902224)2.83968415
173imidazole-containing compound metabolic process (GO:0052803)2.83020525
174regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82897456
175regulation of natural killer cell mediated immunity (GO:0002715)2.82897456
176cytolysis (GO:0019835)2.81877234
1773-UTR-mediated mRNA stabilization (GO:0070935)2.81277057
178complement activation, classical pathway (GO:0006958)2.81207172
179cholesterol homeostasis (GO:0042632)2.80912007
180positive regulation of mast cell activation (GO:0033005)2.80810349
181regulation of ARF protein signal transduction (GO:0032012)2.80754135
182production of molecular mediator involved in inflammatory response (GO:0002532)2.80530087
183positive regulation of Cdc42 GTPase activity (GO:0043089)2.80319249
184modulation by symbiont of host cellular process (GO:0044068)2.80188328
185thymic T cell selection (GO:0045061)2.75245801
186positive regulation of fibroblast migration (GO:0010763)2.74162380
187positive regulation of cellular amide metabolic process (GO:0034250)2.73406335
188regulation of tolerance induction (GO:0002643)2.72943621
189negative regulation of innate immune response (GO:0045824)2.72921219
190regulation of B cell differentiation (GO:0045577)2.71948553
191regulation of necroptotic process (GO:0060544)2.71752999
192lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70054932
193negative regulation of cytokine production involved in immune response (GO:0002719)2.68343854
194negative thymic T cell selection (GO:0045060)2.67711141
195actin filament polymerization (GO:0030041)2.67652725
196negative regulation of toll-like receptor signaling pathway (GO:0034122)2.66868995
197positive regulation of Rap GTPase activity (GO:0032854)2.66431033
198interferon-gamma-mediated signaling pathway (GO:0060333)2.64491389
199negative regulation of interleukin-6 production (GO:0032715)2.64353261
200regulation of T cell mediated cytotoxicity (GO:0001914)2.61758780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75948871
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.68366231
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.29207544
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.08719209
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.35756867
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87125143
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.83166313
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71243151
9LXR_22292898_ChIP-Seq_THP-1_Human2.68286946
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.57273556
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44011663
12VDR_24763502_ChIP-Seq_THP-1_Human2.41660501
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32129690
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.26950500
15MYC_22102868_ChIP-Seq_BL_Human2.25625960
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18285681
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16179485
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.13597567
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11355733
20RUNX1_22412390_ChIP-Seq_EML_Mouse2.09337182
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08748159
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08178723
23SPI1_23127762_ChIP-Seq_K562_Human2.07508679
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03546488
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02568969
26ZNF263_19887448_ChIP-Seq_K562_Human1.94770527
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91847753
28KDM2B_26808549_Chip-Seq_DND41_Human1.90624071
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85825674
30VDR_21846776_ChIP-Seq_THP-1_Human1.84559908
31SCL_19346495_ChIP-Seq_HPC-7_Human1.83325948
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.82058917
33* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80194110
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79608370
35SPI1_23547873_ChIP-Seq_NB4_Human1.77960968
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77607721
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.76975562
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76635858
39* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74481307
40RACK7_27058665_Chip-Seq_MCF-7_Human1.74445176
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72975405
42TCF7_22412390_ChIP-Seq_EML_Mouse1.67531239
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66351700
44P68_20966046_ChIP-Seq_HELA_Human1.65053159
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64622488
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64332650
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62940946
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59317437
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59062465
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.58943689
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58414010
52RUNX_20019798_ChIP-Seq_JUKART_Human1.56539882
53KDM2B_26808549_Chip-Seq_K562_Human1.55407008
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54785857
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53600648
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52774441
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48993658
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46591299
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46509359
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46227050
61BCL6_27268052_Chip-Seq_Bcells_Human1.46041119
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44291499
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43666875
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.43519168
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.43154333
66CLOCK_20551151_ChIP-Seq_293T_Human1.43152951
67BCOR_27268052_Chip-Seq_Bcells_Human1.42413819
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41768861
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40280359
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36045811
71CREB1_26743006_Chip-Seq_LNCaP_Human1.35962102
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.35769478
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35597500
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34734835
75MYB_26560356_Chip-Seq_TH2_Human1.34029275
76MYB_26560356_Chip-Seq_TH1_Human1.33597242
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.32893940
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32170464
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30961601
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.30418642
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29876555
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29437086
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27549908
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.27477655
85* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27384073
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27130860
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26883034
88SMC4_20622854_ChIP-Seq_HELA_Human1.26690434
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25543380
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25360019
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23251529
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23121409
93CTCF_27219007_Chip-Seq_Bcells_Human1.20912440
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.20495029
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19645831
96* GATA1_19941826_ChIP-Seq_K562_Human1.18658723
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18481874
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17619188
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17053273
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15709635
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15636549
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14938673
103* MAF_26560356_Chip-Seq_TH1_Human1.14801409
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14047972
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13393668
106ATF3_27146783_Chip-Seq_COLON_Human1.13128660
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12321909
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12173209
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11122838
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11107034
111* PHF8_20622854_ChIP-Seq_HELA_Human1.11038405
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09879027
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09639930
114UTX_26944678_Chip-Seq_JUKART_Human1.09345441
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08573268
116* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07576334
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07418023
118E2F1_20622854_ChIP-Seq_HELA_Human1.07410249
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07009043
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05627459
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04501999
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03621019
123FOXA2_19822575_ChIP-Seq_HepG2_Human1.02151441
124SA1_27219007_Chip-Seq_Bcells_Human1.01911415
125MAF_26560356_Chip-Seq_TH2_Human0.98329830
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98266008
127* CTCF_21964334_Chip-Seq_Bcells_Human0.97683850
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97339201
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96270309
130* GATA2_19941826_ChIP-Seq_K562_Human0.96253162
131TP63_22573176_ChIP-Seq_HFKS_Human0.94405221
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94234825
133SPI1_20517297_ChIP-Seq_HL60_Human0.92905872
134NCOR1_26117541_ChIP-Seq_K562_Human0.91579210
135* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90234433
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90183785
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89306245
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89169464
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.89048362
140DROSHA_22980978_ChIP-Seq_HELA_Human0.88257242
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88213910
142RARB_24833708_ChIP-Seq_LIVER_Mouse0.87573496
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87510869
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.86771907
145EGR1_19374776_ChIP-ChIP_THP-1_Human0.86466582
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86283518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.61708399
2MP0005360_urolithiasis6.06138192
3MP0005085_abnormal_gallbladder_physiolo4.91769440
4MP0005365_abnormal_bile_salt4.79013073
5MP0003436_decreased_susceptibility_to4.30439642
6MP0003724_increased_susceptibility_to4.06430935
7MP0009840_abnormal_foam_cell3.96176484
8MP0008875_abnormal_xenobiotic_pharmacok3.51704925
9MP0010329_abnormal_lipoprotein_level3.33981368
10MP0005083_abnormal_biliary_tract3.17906943
11MP0003705_abnormal_hypodermis_morpholog2.94108249
12MP0003252_abnormal_bile_duct2.93281200
13MP0003191_abnormal_cellular_cholesterol2.89308936
14MP0002419_abnormal_innate_immunity2.89078578
15MP0001835_abnormal_antigen_presentation2.78099071
16MP0004859_abnormal_synaptic_plasticity2.77832266
17MP0008260_abnormal_autophagy2.68616788
18MP0005025_abnormal_response_to2.65953315
19MP0003806_abnormal_nucleotide_metabolis2.61438449
20MP0005387_immune_system_phenotype2.52155064
21MP0001790_abnormal_immune_system2.52155064
22MP0005000_abnormal_immune_tolerance2.46149889
23MP0002822_catalepsy2.45260166
24MP0001800_abnormal_humoral_immune2.33570569
25MP0006082_CNS_inflammation2.32387638
26MP0005332_abnormal_amino_acid2.29229278
27MP0001666_abnormal_nutrient_absorption2.28922965
28MP0005671_abnormal_response_to2.26040727
29MP0002420_abnormal_adaptive_immunity2.25551076
30MP0001819_abnormal_immune_cell2.22981533
31MP0009785_altered_susceptibility_to2.20901460
32MP0002723_abnormal_immune_serum2.17082826
33MP0001533_abnormal_skeleton_physiology2.07762445
34MP0003763_abnormal_thymus_physiology2.06905354
35MP0002452_abnormal_antigen_presenting2.02582306
36MP0000609_abnormal_liver_physiology1.95288332
37MP0003329_amyloid_beta_deposits1.91347056
38MP0002118_abnormal_lipid_homeostasis1.90148963
39MP0002132_abnormal_respiratory_system1.88598421
40MP0005451_abnormal_body_composition1.86221973
41MP0002405_respiratory_system_inflammati1.81027292
42MP0002398_abnormal_bone_marrow1.80176951
43MP0003183_abnormal_peptide_metabolism1.79806760
44MP0010234_abnormal_vibrissa_follicle1.79729923
45MP0002148_abnormal_hypersensitivity_rea1.72751753
46MP0000604_amyloidosis1.72740715
47MP0003866_abnormal_defecation1.69057811
48MP0004510_myositis1.67918609
49MP0005319_abnormal_enzyme/_coenzyme1.67082800
50MP0000716_abnormal_immune_system1.66501484
51MP0004858_abnormal_nervous_system1.66342654
52MP0010155_abnormal_intestine_physiology1.65292815
53MP0005584_abnormal_enzyme/coenzyme_acti1.64557334
54MP0003656_abnormal_erythrocyte_physiolo1.60455816
55MP0002396_abnormal_hematopoietic_system1.58516072
56MP0008961_abnormal_basal_metabolism1.57420889
57MP0002909_abnormal_adrenal_gland1.56263268
58MP0009333_abnormal_splenocyte_physiolog1.54167197
59MP0004130_abnormal_muscle_cell1.51547755
60MP0003075_altered_response_to1.48875350
61MP0003300_gastrointestinal_ulcer1.47150443
62MP0004019_abnormal_vitamin_homeostasis1.46942964
63MP0000858_altered_metastatic_potential1.45028226
64MP0004381_abnormal_hair_follicle1.44529061
65MP0002722_abnormal_immune_system1.42675565
66MP0001845_abnormal_inflammatory_respons1.42376922
67MP0003828_pulmonary_edema1.40017496
68MP0000703_abnormal_thymus_morphology1.39929606
69MP0002429_abnormal_blood_cell1.37903863
70MP0001851_eye_inflammation1.36242723
71MP0000689_abnormal_spleen_morphology1.33417285
72MP0003195_calcinosis1.31168235
73MP0000465_gastrointestinal_hemorrhage1.27354234
74MP0003303_peritoneal_inflammation1.27079628
75MP0009643_abnormal_urine_homeostasis1.26844603
76MP0005167_abnormal_blood-brain_barrier1.21984087
77MP0002998_abnormal_bone_remodeling1.21861486
78MP0005310_abnormal_salivary_gland1.21811652
79MP0003868_abnormal_feces_composition1.17223667
80MP0000598_abnormal_liver_morphology1.15092211
81MP0002138_abnormal_hepatobiliary_system1.14240005
82MP0005377_hearing/vestibular/ear_phenot1.12992828
83MP0003878_abnormal_ear_physiology1.12992828
84MP0003172_abnormal_lysosome_physiology1.11184711
85MP0003566_abnormal_cell_adhesion1.08136615
86MP0008874_decreased_physiological_sensi1.07841637
87MP0005058_abnormal_lysosome_morphology1.06349727
88MP0000490_abnormal_crypts_of1.05174310
89MP0005464_abnormal_platelet_physiology1.04059062
90MP0001958_emphysema1.02915209
91MP0003635_abnormal_synaptic_transmissio1.02380163
92MP0005166_decreased_susceptibility_to1.01058250
93MP0004883_abnormal_blood_vessel1.00565875
94MP0008872_abnormal_physiological_respon0.94552014
95MP0005390_skeleton_phenotype0.94105470
96MP0003045_fibrosis0.93751665
97MP0005076_abnormal_cell_differentiation0.91343426
98MP0002277_abnormal_respiratory_mucosa0.91281767
99MP0003453_abnormal_keratinocyte_physiol0.90834349
100MP0002078_abnormal_glucose_homeostasis0.88282858
101MP0005636_abnormal_mineral_homeostasis0.85530884
102MP0000920_abnormal_myelination0.85418014
103MP0002089_abnormal_postnatal_growth/wei0.84233563
104* MP0009642_abnormal_blood_homeostasis0.83871334
105MP0000343_altered_response_to0.83829241
106MP0003283_abnormal_digestive_organ0.83554294
107MP0001873_stomach_inflammation0.82867059
108MP0001663_abnormal_digestive_system0.81217433
109MP0005535_abnormal_body_temperature0.81166898
110MP0001756_abnormal_urination0.80778752
111MP0006036_abnormal_mitochondrial_physio0.80672177
112MP0003091_abnormal_cell_migration0.80659699
113MP0001764_abnormal_homeostasis0.79931234
114MP0002269_muscular_atrophy0.79180321
115MP0003879_abnormal_hair_cell0.76954831
116MP0002933_joint_inflammation0.75480777
117MP0005164_abnormal_response_to0.74900949
118MP0009780_abnormal_chondrocyte_physiolo0.74140926
119MP0001348_abnormal_lacrimal_gland0.73587270
120MP0003633_abnormal_nervous_system0.72581661
121MP0000747_muscle_weakness0.71650293
122MP0003448_altered_tumor_morphology0.71349735
123MP0003638_abnormal_response/metabolism_0.70515556
124MP0004811_abnormal_neuron_physiology0.70230701
125MP0005666_abnormal_adipose_tissue0.70124132
126MP0002063_abnormal_learning/memory/cond0.69801326
127MP0005670_abnormal_white_adipose0.69110929
128MP0004808_abnormal_hematopoietic_stem0.69073275
129MP0005448_abnormal_energy_balance0.67152851
130MP0008469_abnormal_protein_level0.66742599
131MP0003279_aneurysm0.66330960
132MP0003795_abnormal_bone_structure0.66288978
133MP0001968_abnormal_touch/_nociception0.65736539
134MP0009763_increased_sensitivity_to0.64821176
135MP0001849_ear_inflammation0.64030855
136MP0005334_abnormal_fat_pad0.63923160
137MP0008569_lethality_at_weaning0.63330730
138MP0010352_gastrointestinal_tract_polyps0.62507994
139MP0002133_abnormal_respiratory_system0.62293217
140MP0005388_respiratory_system_phenotype0.62293217
141MP0000685_abnormal_immune_system0.61727287
142MP0008004_abnormal_stomach_pH0.60308492
143MP0002736_abnormal_nociception_after0.60180766
144MP0002970_abnormal_white_adipose0.60180080
145MP0002971_abnormal_brown_adipose0.59552209
146MP0002733_abnormal_thermal_nociception0.58792896
147MP0005375_adipose_tissue_phenotype0.58709811
148MP0009764_decreased_sensitivity_to0.57613966
149MP0002064_seizures0.57124520
150MP0004185_abnormal_adipocyte_glucose0.56922214
151MP0000639_abnormal_adrenal_gland0.56227352
152MP0000013_abnormal_adipose_tissue0.56224441
153MP0001765_abnormal_ion_homeostasis0.55887727
154MP0005220_abnormal_exocrine_pancreas0.55410606
155MP0004947_skin_inflammation0.54921327
156MP0003690_abnormal_glial_cell0.54852584
157MP0006035_abnormal_mitochondrial_morpho0.54082537
158MP0002136_abnormal_kidney_physiology0.54037901
159MP0009745_abnormal_behavioral_response0.53844101
160MP0008873_increased_physiological_sensi0.52469840
161MP0004270_analgesia0.51768915
162MP0009278_abnormal_bone_marrow0.51553971
163MP0009765_abnormal_xenobiotic_induced0.51429567
164MP0005023_abnormal_wound_healing0.51177586
165MP0000003_abnormal_adipose_tissue0.51129572
166MP0008770_decreased_survivor_rate0.50875046
167MP0003953_abnormal_hormone_level0.50773236
168MP0005397_hematopoietic_system_phenotyp0.50631031
169MP0001545_abnormal_hematopoietic_system0.50631031
170MP0009672_abnormal_birth_weight0.49347013

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.28293277
2Eczematoid dermatitis (HP:0000976)6.27930024
3Deep venous thrombosis (HP:0002625)5.60115506
4Recurrent abscess formation (HP:0002722)5.13251267
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.97750554
6Recurrent bacterial skin infections (HP:0005406)4.85958364
7Abnormality of macrophages (HP:0004311)4.79947627
8Myositis (HP:0100614)4.74880567
9Xanthomatosis (HP:0000991)4.63508079
10Hypochromic anemia (HP:0001931)4.59011255
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45940240
12Orchitis (HP:0100796)4.31978277
13Recurrent gram-negative bacterial infections (HP:0005420)4.28841036
14Intrahepatic cholestasis (HP:0001406)4.21191782
15Hypobetalipoproteinemia (HP:0003563)3.94573977
16Obstructive lung disease (HP:0006536)3.82042142
17Chronic obstructive pulmonary disease (HP:0006510)3.82042142
18Stomatitis (HP:0010280)3.73665724
19Hyperlipoproteinemia (HP:0010980)3.69497450
20Complement deficiency (HP:0004431)3.68454906
21Optic neuritis (HP:0100653)3.67212228
22Retrobulbar optic neuritis (HP:0100654)3.67212228
23Gastrointestinal infarctions (HP:0005244)3.60996778
24Increased IgE level (HP:0003212)3.58735310
25Elevated erythrocyte sedimentation rate (HP:0003565)3.54353109
26Cellulitis (HP:0100658)3.51716974
27Abnormality of the heme biosynthetic pathway (HP:0010472)3.48353198
28Ketosis (HP:0001946)3.43971237
29Hyperammonemia (HP:0001987)3.41560793
30Mediastinal lymphadenopathy (HP:0100721)3.39230779
31Urticaria (HP:0001025)3.33720950
32Meningitis (HP:0001287)3.30746656
33Gingivitis (HP:0000230)3.29678355
34Spontaneous hematomas (HP:0007420)3.29209559
35Microcytic anemia (HP:0001935)3.24490441
36Prolonged bleeding time (HP:0003010)3.23929797
37Abnormality of the Achilles tendon (HP:0005109)3.11392058
38Recurrent fungal infections (HP:0002841)3.09451412
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09371632
40Abnormality of the lower motor neuron (HP:0002366)3.04768917
41Prolonged partial thromboplastin time (HP:0003645)3.03177449
42Hypolipoproteinemia (HP:0010981)3.02281444
43Recurrent skin infections (HP:0001581)3.01412900
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.98030654
45Myokymia (HP:0002411)2.92817840
46Neonatal onset (HP:0003623)2.88575741
47Abnormality of complement system (HP:0005339)2.85919459
48Abnormality of the common coagulation pathway (HP:0010990)2.83961927
49Episodic fever (HP:0001954)2.83522317
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.79908772
51Hypoalphalipoproteinemia (HP:0003233)2.78337417
52Spastic diplegia (HP:0001264)2.76868687
53Encephalitis (HP:0002383)2.74010510
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72693949
55Gastrointestinal inflammation (HP:0004386)2.72308664
56Abnormal gallbladder physiology (HP:0012438)2.72138402
57Cholecystitis (HP:0001082)2.72138402
58Hyperglycinuria (HP:0003108)2.70855623
59Hyperglycinemia (HP:0002154)2.70434458
60Achilles tendon contracture (HP:0001771)2.69850261
61Keratoconjunctivitis sicca (HP:0001097)2.69549401
62Slow saccadic eye movements (HP:0000514)2.67162942
63Abnormality of serine family amino acid metabolism (HP:0010894)2.65137933
64Abnormality of glycine metabolism (HP:0010895)2.65137933
65Chest pain (HP:0100749)2.64383883
66Inflammation of the large intestine (HP:0002037)2.64287177
67Gout (HP:0001997)2.64141571
68Hyperbilirubinemia (HP:0002904)2.62809513
69Vasculitis (HP:0002633)2.62802656
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62291783
71Epidermoid cyst (HP:0200040)2.62206566
72Ketoacidosis (HP:0001993)2.61161840
73Petechiae (HP:0000967)2.60835180
74Reticulocytosis (HP:0001923)2.59451448
75Hypercholesterolemia (HP:0003124)2.56095810
76Peritonitis (HP:0002586)2.55964012
77Cholelithiasis (HP:0001081)2.49909658
78Hypoglycemic coma (HP:0001325)2.45940500
79Abnormal hemoglobin (HP:0011902)2.45844838
80Insomnia (HP:0100785)2.45198546
81Joint hemorrhage (HP:0005261)2.44377604
82Delayed CNS myelination (HP:0002188)2.44171478
83Late onset (HP:0003584)2.42849239
84Epistaxis (HP:0000421)2.41612740
85Keratoconjunctivitis (HP:0001096)2.40439650
86Purpura (HP:0000979)2.38703111
87Polycythemia (HP:0001901)2.37479292
88Gingival bleeding (HP:0000225)2.35683705
89Hyperacusis (HP:0010780)2.35450924
90Upper limb amyotrophy (HP:0009129)2.35205844
91Distal upper limb amyotrophy (HP:0007149)2.35205844
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34534378
93Osteomyelitis (HP:0002754)2.33419152
94Abnormality of pyrimidine metabolism (HP:0004353)2.29386554
95Recurrent cutaneous fungal infections (HP:0011370)2.28888348
96Chronic mucocutaneous candidiasis (HP:0002728)2.28888348
97Abnormal gallbladder morphology (HP:0012437)2.28763954
98Torticollis (HP:0000473)2.26195817
99Obstructive sleep apnea (HP:0002870)2.24702179
100Status epilepticus (HP:0002133)2.23932130
101Pustule (HP:0200039)2.23330214
102Abnormality of fatty-acid metabolism (HP:0004359)2.23160784
103Global brain atrophy (HP:0002283)2.21273231
104Craniofacial dystonia (HP:0012179)2.20569843
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20457104
106Fat malabsorption (HP:0002630)2.18493681
107Abnormality of the intrinsic pathway (HP:0010989)2.18119806
108Turricephaly (HP:0000262)2.17836295
109Malnutrition (HP:0004395)2.17615843
110Hepatocellular carcinoma (HP:0001402)2.16451468
111Hand muscle atrophy (HP:0009130)2.16120684
112Toxemia of pregnancy (HP:0100603)2.16088583
113Focal dystonia (HP:0004373)2.15886599
114Death in childhood (HP:0003819)2.15121342
115Sensorimotor neuropathy (HP:0007141)2.14177136
116Metaphyseal cupping (HP:0003021)2.13888334
117Mitral stenosis (HP:0001718)2.12017546
118Abnormal platelet volume (HP:0011876)2.11016089
119Sepsis (HP:0100806)2.09496000
120Abnormality of nucleobase metabolism (HP:0010932)2.09484868
121Colitis (HP:0002583)2.08752851
122Pulmonary embolism (HP:0002204)2.08438216
123Poikilocytosis (HP:0004447)2.08225942
124Pulmonary infiltrates (HP:0002113)2.06921102
125Segmental peripheral demyelination/remyelination (HP:0003481)2.06251353
126Anorexia (HP:0002039)2.03917983
127Hemoptysis (HP:0002105)2.01922969
128Polygenic inheritance (HP:0010982)2.01690681
129Increased cerebral lipofuscin (HP:0011813)2.01240856
130Arterial thrombosis (HP:0004420)2.00257575
131Back pain (HP:0003418)2.00171041
132Lymphopenia (HP:0001888)2.00162521
133Skin nodule (HP:0200036)1.99905562
134Abnormality of purine metabolism (HP:0004352)1.99534025
135Abnormality of methionine metabolism (HP:0010901)1.99027623
136Acanthocytosis (HP:0001927)1.98462609
137Supranuclear gaze palsy (HP:0000605)1.97362405
138Difficulty running (HP:0009046)1.96655751
139Hepatosplenomegaly (HP:0001433)1.96521667
140Long toe (HP:0010511)1.95982593
141Systemic lupus erythematosus (HP:0002725)1.95140870
142Loss of speech (HP:0002371)1.95103293
143Myocardial infarction (HP:0001658)1.94984000
144Recurrent viral infections (HP:0004429)1.93508015
145Lymphangioma (HP:0100764)1.91577290
146Nasal polyposis (HP:0100582)1.91512343
147Increased IgM level (HP:0003496)1.91337662
148Generalized hyperpigmentation (HP:0007440)1.90976871
149Abnormality of binocular vision (HP:0011514)1.90117361
150Diplopia (HP:0000651)1.90117361
151Increased serum ferritin (HP:0003281)1.89142045
152Cerebral aneurysm (HP:0004944)1.87160219
153Hypergammaglobulinemia (HP:0010702)1.86226394
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.86100933
155Myoglobinuria (HP:0002913)1.85589073
156Abnormality of the peritoneum (HP:0002585)1.85045362
157Hypermelanotic macule (HP:0001034)1.84215339
158Acne (HP:0001061)1.84106596
159Amyloidosis (HP:0011034)1.83985674
160Ankle clonus (HP:0011448)1.83630103
161Leukocytosis (HP:0001974)1.83550883
162Abnormality of the pericardium (HP:0001697)1.83285920
163Increased connective tissue (HP:0009025)1.82569075
164Abnormality of the gallbladder (HP:0005264)1.80930424
165Premature loss of primary teeth (HP:0006323)1.80850219
166Annular pancreas (HP:0001734)1.80441817
167Visual hallucinations (HP:0002367)1.80162088
168Abnormal cartilage morphology (HP:0002763)1.79980321
169Granulocytopenia (HP:0001913)1.79858260
170Interstitial pulmonary disease (HP:0006530)1.79593663
171Abnormal social behavior (HP:0012433)1.78843203
172Impaired social interactions (HP:0000735)1.78843203
173Skin ulcer (HP:0200042)1.78548247
174Gastrointestinal stroma tumor (HP:0100723)1.77952616
175Panhypogammaglobulinemia (HP:0003139)1.77539103
176Hypertriglyceridemia (HP:0002155)1.77466613
177Stroke (HP:0001297)1.77078849
178Renovascular hypertension (HP:0100817)1.76903959
179Irritability (HP:0000737)1.76105816
180Neuronal loss in central nervous system (HP:0002529)1.75859617
181Elfin facies (HP:0004428)1.75145606
182Abnormality of the nasal mucosa (HP:0000433)1.75098213
183Esophageal varix (HP:0002040)1.75089409
184T lymphocytopenia (HP:0005403)1.74722385
185Hemiplegia (HP:0002301)1.74665035
186Cerebral inclusion bodies (HP:0100314)1.73803114
187Hemorrhage of the eye (HP:0011885)1.72346832
188Glomerulopathy (HP:0100820)1.71231281
189Increased variability in muscle fiber diameter (HP:0003557)1.70495752
190Growth hormone excess (HP:0000845)1.70242756
191Abnormality of iron homeostasis (HP:0011031)1.68267500
192Abnormality of transition element cation homeostasis (HP:0011030)1.67945510
193Atrioventricular block (HP:0001678)1.67879188
194Metabolic acidosis (HP:0001942)1.66504020
195Depression (HP:0000716)1.64793023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.10289249
2RIPK44.26051095
3PKN24.23085830
4ERN12.99084792
5PRPF4B2.93382961
6BCKDK2.84845785
7EEF2K2.66541543
8IRAK42.53603400
9KSR22.50823378
10MAP3K102.50306312
11SIK12.24664987
12MAP3K92.23709910
13DAPK22.10607164
14MAP3K32.10104596
15SMG12.01144616
16CSK1.96867653
17CAMKK11.87842942
18RIPK11.86194492
19FGFR41.86116888
20TAOK11.80570443
21SCYL21.78310999
22TAOK21.70922988
23EPHA41.58830480
24PTK61.55116263
25NEK11.55083043
26GRK61.47942468
27PRKD31.46541299
28FGR1.44989645
29SIK21.40087921
30PRKD21.36763006
31BTK1.34446190
32PAK61.33450591
33RET1.33031047
34MAP3K71.32396636
35ICK1.32128444
36MAP4K11.30626720
37SIK31.26031633
38NTRK11.24489497
39LMTK21.24487254
40* HCK1.20894000
41LRRK21.19762480
42MAP3K111.19277602
43PDGFRA1.16621591
44BMX1.15884206
45MAP2K41.15553627
46JAK31.15073977
47SYK1.13011647
48ALK1.11974480
49DAPK11.11938537
50MAP3K21.10643632
51FLT31.09211116
52TESK21.02570653
53NTRK30.99091916
54MINK10.99031618
55MAPK110.98521537
56PRKCH0.97820296
57CDK190.97541276
58MAP3K130.92334951
59MAP3K10.90930507
60DAPK30.88912205
61TYRO30.87697555
62STK380.87683027
63JAK20.85856466
64LYN0.85069330
65KSR10.83624717
66IKBKE0.81092771
67PDPK10.80829467
68KDR0.80206869
69PDK10.79018559
70MAPKAPK30.78478086
71ARAF0.77239111
72LCK0.76796760
73TBK10.75238185
74TTN0.74491017
75MAP2K10.73668338
76HIPK20.72833876
77CDC42BPA0.71723317
78PTK2B0.70994560
79CSF1R0.70134431
80PAK40.68451376
81IRAK20.67603494
82MAP3K60.67520002
83FYN0.67074624
84JAK10.65242113
85PINK10.65052471
86PTK20.64289551
87MAP2K20.63941804
88DYRK1B0.63788391
89YES10.63652603
90RAF10.63578599
91MARK30.63492043
92PRKCZ0.62455148
93MAP2K30.61793870
94FES0.59960956
95RPS6KA20.59295517
96MARK20.58055082
97MAP3K40.57902465
98TNK20.57899701
99MAP3K140.56618325
100ITK0.56128505
101RPS6KC10.54674414
102RPS6KL10.54674414
103TYK20.53815572
104TESK10.52081172
105ZAP700.51950862
106CDK50.51226943
107SGK30.51064119
108ILK0.50860395
109MTOR0.47605408
110MAP2K60.46361760
111TXK0.46022919
112CAMK40.45784273
113GRK50.45639617
114LATS20.45406578
115KIT0.43122352
116MAP3K80.42946813
117MAPK70.42685245
118UHMK10.42157519
119CDK120.42027647
120ERBB20.41509163
121STK100.41195294
122STK110.40282373
123PRKG20.39641111
124DDR20.39590431
125NEK20.39289989
126RPS6KA60.38858497
127EPHB10.38838375
128BRAF0.38601903
129IRAK30.37357186
130NTRK20.36935463
131MAPK120.36821381
132BLK0.35662392
133PRKCG0.35065236
134PHKG20.34429229
135PHKG10.34429229
136CAMK10.33259176
137RPS6KA10.31937556
138MATK0.31758519
139PRKD10.31417094
140CDK150.31065662
141PRKAA10.31040151

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.67874401
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.85631418
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.84611527
4Arginine biosynthesis_Homo sapiens_hsa002203.22656611
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86321155
6Osteoclast differentiation_Homo sapiens_hsa043802.63707863
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40033956
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36703079
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.28621460
10Leishmaniasis_Homo sapiens_hsa051402.24811558
11Fatty acid degradation_Homo sapiens_hsa000712.22907666
12Tryptophan metabolism_Homo sapiens_hsa003802.13356224
13B cell receptor signaling pathway_Homo sapiens_hsa046622.12146215
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06921308
15Bile secretion_Homo sapiens_hsa049761.96416068
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91884062
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90892542
18Malaria_Homo sapiens_hsa051441.89362912
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88291001
20Complement and coagulation cascades_Homo sapiens_hsa046101.87264391
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81818539
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78252617
23Butanoate metabolism_Homo sapiens_hsa006501.75365916
24PPAR signaling pathway_Homo sapiens_hsa033201.74365270
25Tuberculosis_Homo sapiens_hsa051521.71744031
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69106174
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62451740
28Biosynthesis of amino acids_Homo sapiens_hsa012301.59775931
29Chemokine signaling pathway_Homo sapiens_hsa040621.56171240
30Fatty acid metabolism_Homo sapiens_hsa012121.50114626
31Graft-versus-host disease_Homo sapiens_hsa053321.49661488
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.46349031
33Allograft rejection_Homo sapiens_hsa053301.46026971
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45843173
35T cell receptor signaling pathway_Homo sapiens_hsa046601.41601207
36Primary immunodeficiency_Homo sapiens_hsa053401.40866140
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.39971022
38African trypanosomiasis_Homo sapiens_hsa051431.39888183
39Carbon metabolism_Homo sapiens_hsa012001.39201402
40Propanoate metabolism_Homo sapiens_hsa006401.39120370
41beta-Alanine metabolism_Homo sapiens_hsa004101.37623308
42Caffeine metabolism_Homo sapiens_hsa002321.37236910
43Autoimmune thyroid disease_Homo sapiens_hsa053201.36156918
44Peroxisome_Homo sapiens_hsa041461.31708714
45Other glycan degradation_Homo sapiens_hsa005111.29558022
46Measles_Homo sapiens_hsa051621.28892008
47Pancreatic cancer_Homo sapiens_hsa052121.28443845
48Toxoplasmosis_Homo sapiens_hsa051451.28382457
49Sulfur relay system_Homo sapiens_hsa041221.28325100
50Pyruvate metabolism_Homo sapiens_hsa006201.27388668
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.26082884
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26069332
53Selenocompound metabolism_Homo sapiens_hsa004501.25456690
54Fat digestion and absorption_Homo sapiens_hsa049751.21984220
55Viral myocarditis_Homo sapiens_hsa054161.19517543
56Endocytosis_Homo sapiens_hsa041441.17137304
57Phagosome_Homo sapiens_hsa041451.16134190
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13909330
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13640629
60Influenza A_Homo sapiens_hsa051641.12378192
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.11266464
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.10808138
63Platelet activation_Homo sapiens_hsa046111.09774772
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06583639
65Staphylococcus aureus infection_Homo sapiens_hsa051501.06484307
66Notch signaling pathway_Homo sapiens_hsa043301.06107616
67Hepatitis C_Homo sapiens_hsa051601.06012492
68Chemical carcinogenesis_Homo sapiens_hsa052041.05044605
69ABC transporters_Homo sapiens_hsa020101.04151192
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03367396
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02753255
72Renal cell carcinoma_Homo sapiens_hsa052111.02591838
73Antigen processing and presentation_Homo sapiens_hsa046121.02282387
74GnRH signaling pathway_Homo sapiens_hsa049121.01116680
75NF-kappa B signaling pathway_Homo sapiens_hsa040641.00669437
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00339158
77Hematopoietic cell lineage_Homo sapiens_hsa046401.00277943
78Type I diabetes mellitus_Homo sapiens_hsa049400.99191434
79Histidine metabolism_Homo sapiens_hsa003400.99071620
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98636829
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98481711
82Phenylalanine metabolism_Homo sapiens_hsa003600.98236966
83Shigellosis_Homo sapiens_hsa051310.98059704
84Salmonella infection_Homo sapiens_hsa051320.97490079
85TNF signaling pathway_Homo sapiens_hsa046680.97206476
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.97133500
87Herpes simplex infection_Homo sapiens_hsa051680.96740263
88Starch and sucrose metabolism_Homo sapiens_hsa005000.95787169
89Hepatitis B_Homo sapiens_hsa051610.95249275
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93301277
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.93186198
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92390522
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92147304
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91376458
95Choline metabolism in cancer_Homo sapiens_hsa052310.89461161
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89263304
97Apoptosis_Homo sapiens_hsa042100.88026660
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85257887
99Glycerolipid metabolism_Homo sapiens_hsa005610.84801162
100Lysine degradation_Homo sapiens_hsa003100.83272642
101Prolactin signaling pathway_Homo sapiens_hsa049170.82287360
102ErbB signaling pathway_Homo sapiens_hsa040120.81112864
103Pentose phosphate pathway_Homo sapiens_hsa000300.80842304
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80342945
105Inositol phosphate metabolism_Homo sapiens_hsa005620.79355782
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79331589
107Legionellosis_Homo sapiens_hsa051340.77630976
108Rap1 signaling pathway_Homo sapiens_hsa040150.76370756
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.74581645
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74358159
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.74234757
112Amoebiasis_Homo sapiens_hsa051460.72937835
113Colorectal cancer_Homo sapiens_hsa052100.72909127
114Prion diseases_Homo sapiens_hsa050200.71945261
115Insulin resistance_Homo sapiens_hsa049310.71222127
116Pertussis_Homo sapiens_hsa051330.69990601
117Synaptic vesicle cycle_Homo sapiens_hsa047210.69492410
118Folate biosynthesis_Homo sapiens_hsa007900.69175805
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68038180
120MAPK signaling pathway_Homo sapiens_hsa040100.67677844
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.67663301
122Lysosome_Homo sapiens_hsa041420.67083209
123Fructose and mannose metabolism_Homo sapiens_hsa000510.65421016
124HIF-1 signaling pathway_Homo sapiens_hsa040660.64306518
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64194759
126Tyrosine metabolism_Homo sapiens_hsa003500.62525371
127FoxO signaling pathway_Homo sapiens_hsa040680.62472235
128Arginine and proline metabolism_Homo sapiens_hsa003300.62118557
129Insulin signaling pathway_Homo sapiens_hsa049100.61848795
130Viral carcinogenesis_Homo sapiens_hsa052030.59905172
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58142833
132Non-small cell lung cancer_Homo sapiens_hsa052230.56700723
133HTLV-I infection_Homo sapiens_hsa051660.56685566
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56198340
135Galactose metabolism_Homo sapiens_hsa000520.55902487
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55485076
137Olfactory transduction_Homo sapiens_hsa047400.55387033
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55292004
139Retinol metabolism_Homo sapiens_hsa008300.54837944
140mTOR signaling pathway_Homo sapiens_hsa041500.53806507
141Bladder cancer_Homo sapiens_hsa052190.53728012
142Glucagon signaling pathway_Homo sapiens_hsa049220.52907065
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.51367796
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50824304
145Glioma_Homo sapiens_hsa052140.50032884
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49193111
147Fatty acid biosynthesis_Homo sapiens_hsa000610.48402925
148Type II diabetes mellitus_Homo sapiens_hsa049300.47170748
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46723919
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46529487
151VEGF signaling pathway_Homo sapiens_hsa043700.45527246
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45328061
153AMPK signaling pathway_Homo sapiens_hsa041520.44961959
154Chronic myeloid leukemia_Homo sapiens_hsa052200.36067628
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35460517
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34931915
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.31664074
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31641317
159Gastric acid secretion_Homo sapiens_hsa049710.31151032
160Maturity onset diabetes of the young_Homo sapiens_hsa049500.29504243
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29477775
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28152449
163Endometrial cancer_Homo sapiens_hsa052130.26384389
164Acute myeloid leukemia_Homo sapiens_hsa052210.25750265
165Estrogen signaling pathway_Homo sapiens_hsa049150.25286598
166Thyroid cancer_Homo sapiens_hsa052160.25205078
167Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24160920
168Insulin secretion_Homo sapiens_hsa049110.24014032
169Long-term potentiation_Homo sapiens_hsa047200.23907847
170Glycerophospholipid metabolism_Homo sapiens_hsa005640.22075921
171Thyroid hormone synthesis_Homo sapiens_hsa049180.21483859
172Vitamin B6 metabolism_Homo sapiens_hsa007500.21469132
173GABAergic synapse_Homo sapiens_hsa047270.20394056

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