FKBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.65171277
2DNA unwinding involved in DNA replication (GO:0006268)4.44976858
3negative regulation of erythrocyte differentiation (GO:0045647)4.15864211
4protein localization to kinetochore (GO:0034501)3.97329677
5mitotic chromosome condensation (GO:0007076)3.92625725
6detection of molecule of bacterial origin (GO:0032490)3.83203594
7germinal center formation (GO:0002467)3.82841047
8negative regulation of cell killing (GO:0031342)3.81530998
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81530998
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72169610
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71992058
12positive regulation by symbiont of host defense response (GO:0052509)3.65382416
13modulation by symbiont of host defense response (GO:0052031)3.65382416
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65382416
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65382416
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.65382416
17modulation by symbiont of host immune response (GO:0052553)3.65382416
18positive thymic T cell selection (GO:0045059)3.56838761
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51927166
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51927166
21regulation of B cell receptor signaling pathway (GO:0050855)3.49867130
22positive regulation of B cell differentiation (GO:0045579)3.44578132
23regulation of translational fidelity (GO:0006450)3.44114793
24valine metabolic process (GO:0006573)3.44044937
25negative thymic T cell selection (GO:0045060)3.43530018
26response to interleukin-15 (GO:0070672)3.43095738
27negative T cell selection (GO:0043383)3.42877611
28response to peptidoglycan (GO:0032494)3.41092592
29detection of external biotic stimulus (GO:0098581)3.34876672
30detection of other organism (GO:0098543)3.27112223
31sister chromatid segregation (GO:0000819)3.26266129
32nuclear pore complex assembly (GO:0051292)3.23604877
33heterochromatin organization (GO:0070828)3.23360003
34DNA duplex unwinding (GO:0032508)3.20729345
35regulation of gamma-delta T cell differentiation (GO:0045586)3.19529178
36mitotic sister chromatid segregation (GO:0000070)3.19019541
37dosage compensation (GO:0007549)3.18866706
38glycine metabolic process (GO:0006544)3.18440624
39mitotic nuclear envelope disassembly (GO:0007077)3.18353928
40nuclear pore organization (GO:0006999)3.18091875
41protein localization to chromosome, centromeric region (GO:0071459)3.17942888
42DNA geometric change (GO:0032392)3.17599089
43sulfur amino acid catabolic process (GO:0000098)3.17284691
44mitotic sister chromatid cohesion (GO:0007064)3.17115763
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15174226
46positive T cell selection (GO:0043368)3.14537307
47negative regulation of histone methylation (GO:0031061)3.13869653
48negative regulation of T cell mediated immunity (GO:0002710)3.12619121
49cellular response to growth hormone stimulus (GO:0071378)3.10980278
50neutrophil activation involved in immune response (GO:0002283)3.10022372
51tetrahydrofolate metabolic process (GO:0046653)3.09061143
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07836535
53detection of bacterium (GO:0016045)3.07388472
54one-carbon metabolic process (GO:0006730)3.06384692
55thymic T cell selection (GO:0045061)3.06036200
56V(D)J recombination (GO:0033151)3.01644602
57regulation of B cell differentiation (GO:0045577)3.01434386
58macrophage activation involved in immune response (GO:0002281)3.00400943
59nuclear envelope disassembly (GO:0051081)2.99644907
60membrane disassembly (GO:0030397)2.99644907
61immunoglobulin mediated immune response (GO:0016064)2.98676664
62T cell selection (GO:0045058)2.96491011
63cellular hyperosmotic response (GO:0071474)2.95379093
64negative regulation of interleukin-12 production (GO:0032695)2.94620305
65pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.93603300
66UMP metabolic process (GO:0046049)2.93603300
67pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.93603300
68UMP biosynthetic process (GO:0006222)2.93603300
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.91340384
70IMP biosynthetic process (GO:0006188)2.91336801
71histone H2A monoubiquitination (GO:0035518)2.90857836
72low-density lipoprotein particle clearance (GO:0034383)2.90111350
73urea cycle (GO:0000050)2.89548172
74urea metabolic process (GO:0019627)2.89548172
75Peyers patch development (GO:0048541)2.88445172
76mucosal-associated lymphoid tissue development (GO:0048537)2.88445172
77cellular extravasation (GO:0045123)2.87624629
78lysine metabolic process (GO:0006553)2.85149457
79lysine catabolic process (GO:0006554)2.85149457
80detection of biotic stimulus (GO:0009595)2.84403186
81serine family amino acid biosynthetic process (GO:0009070)2.84394191
822-oxoglutarate metabolic process (GO:0006103)2.84169497
83pentose-phosphate shunt (GO:0006098)2.84118756
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83007111
85regulation of translational termination (GO:0006449)2.80726449
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80203572
87growth hormone receptor signaling pathway (GO:0060396)2.78424546
88regulation of histone H3-K9 methylation (GO:0051570)2.78053303
89antigen processing and presentation of endogenous antigen (GO:0019883)2.77597070
90DNA replication initiation (GO:0006270)2.76895434
91IMP metabolic process (GO:0046040)2.76558060
92alpha-linolenic acid metabolic process (GO:0036109)2.75485759
93regulation of interferon-beta biosynthetic process (GO:0045357)2.75465194
94tolerance induction (GO:0002507)2.73652401
95response to host immune response (GO:0052572)2.73622558
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73622558
97tricarboxylic acid metabolic process (GO:0072350)2.72977392
98NADPH regeneration (GO:0006740)2.72854982
99regulation of necroptotic process (GO:0060544)2.72587040
100DNA strand elongation involved in DNA replication (GO:0006271)2.72251798
101pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70969855
102chromatin assembly (GO:0031497)2.70121529
103positive regulation of chromosome segregation (GO:0051984)2.70099852
104positive regulation of granulocyte differentiation (GO:0030854)2.69700521
105peptidyl-lysine dimethylation (GO:0018027)2.69600567
106regulation of sister chromatid cohesion (GO:0007063)2.69587254
107creatine metabolic process (GO:0006600)2.68827300
108positive regulation of tolerance induction (GO:0002645)2.67948535
109production of molecular mediator involved in inflammatory response (GO:0002532)2.64514362
110cellular response to interleukin-15 (GO:0071350)2.63988000
111regulation of gamma-delta T cell activation (GO:0046643)2.63979637
112maternal placenta development (GO:0001893)2.63452291
113response to muramyl dipeptide (GO:0032495)2.63379722
114L-phenylalanine metabolic process (GO:0006558)2.62656867
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62656867
116positive regulation of histone deacetylation (GO:0031065)2.61905023
117cysteine metabolic process (GO:0006534)2.60899670
118serine family amino acid catabolic process (GO:0009071)2.60470539
119response to host (GO:0075136)2.60335394
120response to host defenses (GO:0052200)2.60335394
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60335394
122RNA stabilization (GO:0043489)2.60103550
123mRNA stabilization (GO:0048255)2.60103550
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58957725
125regulation of tolerance induction (GO:0002643)2.58686692
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58137074
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58003117
128serine family amino acid metabolic process (GO:0009069)2.57845759
129glyoxylate metabolic process (GO:0046487)2.57815264
130Golgi transport vesicle coating (GO:0048200)2.57521393
131COPI coating of Golgi vesicle (GO:0048205)2.57521393
132negative regulation of leukocyte mediated immunity (GO:0002704)2.57104154
133monoubiquitinated protein deubiquitination (GO:0035520)2.56815324
134pteridine-containing compound biosynthetic process (GO:0042559)2.56449733
135antigen processing and presentation via MHC class Ib (GO:0002475)2.56057773
136DNA strand elongation (GO:0022616)2.55674366
137nuclear envelope organization (GO:0006998)2.55608528
138B cell receptor signaling pathway (GO:0050853)2.55312039
139folic acid metabolic process (GO:0046655)2.54999479
140response to type I interferon (GO:0034340)2.54613860
141amyloid precursor protein catabolic process (GO:0042987)2.54190696
142type I interferon signaling pathway (GO:0060337)2.54013376
143cellular response to type I interferon (GO:0071357)2.54013376
144DNA replication-dependent nucleosome organization (GO:0034723)2.53820789
145DNA replication-dependent nucleosome assembly (GO:0006335)2.53820789
146nitrogen cycle metabolic process (GO:0071941)2.53278718
147negative regulation of T-helper cell differentiation (GO:0045623)2.52981588
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52981588
149nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52602462
150negative regulation of T cell apoptotic process (GO:0070233)2.52452685
151folic acid-containing compound metabolic process (GO:0006760)2.52168890
152DNA conformation change (GO:0071103)2.49737366
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.49723620
154L-phenylalanine catabolic process (GO:0006559)2.49723620
155regulation of T cell tolerance induction (GO:0002664)2.48993574
156regulation of cholesterol homeostasis (GO:2000188)2.48619621
157protein localization to chromosome (GO:0034502)2.47974528
158definitive hemopoiesis (GO:0060216)2.46405797
159nucleobase biosynthetic process (GO:0046112)2.46251446
160cellular response to thyroid hormone stimulus (GO:0097067)2.45952763
161mitotic G1 DNA damage checkpoint (GO:0031571)2.44479085
162L-serine metabolic process (GO:0006563)2.44043999
163leukocyte aggregation (GO:0070486)2.44015285
164kynurenine metabolic process (GO:0070189)2.43424642
165gene silencing by RNA (GO:0031047)2.41340115
166regulation of alpha-beta T cell proliferation (GO:0046640)2.40970330
167L-alpha-amino acid transmembrane transport (GO:1902475)2.40940374
168B cell mediated immunity (GO:0019724)2.40477585
169positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.40340496
170pore complex assembly (GO:0046931)2.40295113
171positive regulation of gamma-delta T cell activation (GO:0046645)2.39941689
172nucleotide salvage (GO:0043173)2.39305861
173megakaryocyte development (GO:0035855)2.39139088
174negative regulation of innate immune response (GO:0045824)2.38213323
175cellular response to epinephrine stimulus (GO:0071872)2.38039239
176negative regulation of type 2 immune response (GO:0002829)2.37902316
177oxaloacetate metabolic process (GO:0006107)2.37537967
178mitotic metaphase plate congression (GO:0007080)2.37210403
179pre-miRNA processing (GO:0031054)2.37155704
180chromosome condensation (GO:0030261)2.37148461
181pyrimidine nucleoside salvage (GO:0043097)2.36626649
182regulation of macrophage cytokine production (GO:0010935)2.36038653
183regulation of regulatory T cell differentiation (GO:0045589)2.35737453
184complement activation, alternative pathway (GO:0006957)2.35400346
185regulation of hypersensitivity (GO:0002883)2.33304194
1863-UTR-mediated mRNA stabilization (GO:0070935)2.31535141
187regulation of granulocyte differentiation (GO:0030852)2.31201246
188neutrophil activation (GO:0042119)2.31149889
189positive regulation of interferon-alpha production (GO:0032727)2.30268972
190macrophage activation (GO:0042116)2.30079563
191carnitine shuttle (GO:0006853)2.29480379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.50936176
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.81986282
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.63703919
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.48916268
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00545382
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35289456
7* MYC_22102868_ChIP-Seq_BL_Human3.06165008
8RUNX_20019798_ChIP-Seq_JUKART_Human2.73624012
9* EGR1_19374776_ChIP-ChIP_THP-1_Human2.70019535
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58057264
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56766856
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54506634
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54151310
14GATA1_22025678_ChIP-Seq_K562_Human2.53303760
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50142305
16* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45371116
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44828707
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.36727884
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36121896
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35185260
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33825593
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.22847878
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.19406011
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08676954
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.01188824
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97388912
27* AR_21909140_ChIP-Seq_LNCAP_Human1.95821908
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94964934
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92821679
30SPI1_23127762_ChIP-Seq_K562_Human1.88476652
31VDR_21846776_ChIP-Seq_THP-1_Human1.88065976
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85825021
33SPI1_23547873_ChIP-Seq_NB4_Human1.81360448
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.79888726
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79621432
36* LXR_22158963_ChIP-Seq_LIVER_Mouse1.79479366
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77526511
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.71100295
39GATA1_19941826_ChIP-Seq_K562_Human1.68339992
40TCF7_22412390_ChIP-Seq_EML_Mouse1.64335908
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61086520
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60634531
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.54397716
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.51208319
45* CLOCK_20551151_ChIP-Seq_293T_Human1.50027294
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48914424
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47352666
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45740120
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.45711013
50* UTX_26944678_Chip-Seq_JUKART_Human1.45189526
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42713078
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41398120
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40857117
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40129364
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40109045
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39674458
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37580974
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37394648
59* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36419829
60MAF_26560356_Chip-Seq_TH1_Human1.35564120
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34521147
62ZNF263_19887448_ChIP-Seq_K562_Human1.32695672
63KDM5A_27292631_Chip-Seq_BREAST_Human1.32284558
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32039709
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31684489
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31608373
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31282506
68CIITA_25753668_ChIP-Seq_RAJI_Human1.31090362
69* VDR_24787735_ChIP-Seq_THP-1_Human1.30768797
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30668370
71GATA2_19941826_ChIP-Seq_K562_Human1.29297158
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28064619
73* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26076035
74PU_27001747_Chip-Seq_BMDM_Mouse1.25911736
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23237398
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22492388
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22013415
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21993540
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21828488
80XRN2_22483619_ChIP-Seq_HELA_Human1.21145756
81* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20921011
82* MYB_26560356_Chip-Seq_TH2_Human1.20734699
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20614489
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.20491512
85* TBX20_22328084_ChIP-Seq_HEART_Mouse1.20491512
86* KDM2B_26808549_Chip-Seq_DND41_Human1.20077471
87* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19010739
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18113247
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17672641
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17409403
91* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16709525
92MYB_26560356_Chip-Seq_TH1_Human1.16277687
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.16163228
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16050324
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16014213
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15361274
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12853822
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12400465
99GATA3_26560356_Chip-Seq_TH2_Human1.10673240
100* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10652210
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10407980
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10314161
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05080919
104* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04120914
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03977456
106* ATF3_27146783_Chip-Seq_COLON_Human1.03614623
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03257406
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03086460
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02432663
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00823468
111* NANOG_21062744_ChIP-ChIP_HESCs_Human1.00025506
112* CHD1_26751641_Chip-Seq_LNCaP_Human0.99673644
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99405182
114NCOR1_26117541_ChIP-Seq_K562_Human0.98606255
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97886976
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97504236
117GATA6_25053715_ChIP-Seq_YYC3_Human0.96668711
118SCL_19346495_ChIP-Seq_HPC-7_Human0.95447115
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.93210882
120* RACK7_27058665_Chip-Seq_MCF-7_Human0.92946063
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.92780073
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92764966
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92642303
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92355144
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92328822
126VDR_24763502_ChIP-Seq_THP-1_Human0.92166248
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91912016
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91442469
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90444502
130* RUNX1_22412390_ChIP-Seq_EML_Mouse0.90218306
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90181114
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89983274
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89012862
134* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87852991
135FOXP3_21729870_ChIP-Seq_TREG_Human0.86334643
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86140277
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84657712
138* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84651113
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84294671
140MAF_26560356_Chip-Seq_TH2_Human0.83933194
141E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83913948
142GABP_19822575_ChIP-Seq_HepG2_Human0.83912738
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83344647
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83324248
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83280272
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82694773
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82482350
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82482350
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82482350
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81609755
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81221434
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80876329
153SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80344037
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79900469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.72819911
2MP0005360_urolithiasis3.07383536
3MP0002139_abnormal_hepatobiliary_system3.01471311
4MP0003436_decreased_susceptibility_to2.85685250
5MP0003705_abnormal_hypodermis_morpholog2.77517529
6MP0003693_abnormal_embryo_hatching2.58508974
7MP0010094_abnormal_chromosome_stability2.57986954
8MP0005365_abnormal_bile_salt2.56940483
9MP0001835_abnormal_antigen_presentation2.51939408
10MP0010352_gastrointestinal_tract_polyps2.50028240
11MP0004957_abnormal_blastocyst_morpholog2.28206217
12MP0005085_abnormal_gallbladder_physiolo2.21073507
13MP0003111_abnormal_nucleus_morphology2.21047730
14MP0010234_abnormal_vibrissa_follicle2.18868109
15MP0003300_gastrointestinal_ulcer2.12553183
16MP0003828_pulmonary_edema2.08475700
17MP0005000_abnormal_immune_tolerance2.07318269
18MP0003806_abnormal_nucleotide_metabolis2.06229952
19MP0001800_abnormal_humoral_immune2.02595189
20MP0005076_abnormal_cell_differentiation1.99868201
21MP0002419_abnormal_innate_immunity1.95486158
22MP0003077_abnormal_cell_cycle1.93010194
23MP0005671_abnormal_response_to1.92826533
24MP0008004_abnormal_stomach_pH1.89134725
25MP0001790_abnormal_immune_system1.87164743
26MP0005387_immune_system_phenotype1.87164743
27MP0009278_abnormal_bone_marrow1.86077542
28MP0005025_abnormal_response_to1.85393179
29MP0009785_altered_susceptibility_to1.83426715
30MP0004185_abnormal_adipocyte_glucose1.82517931
31MP0001661_extended_life_span1.78983562
32MP0003763_abnormal_thymus_physiology1.78878234
33MP0008875_abnormal_xenobiotic_pharmacok1.78456074
34MP0009840_abnormal_foam_cell1.77826465
35MP0002723_abnormal_immune_serum1.76155989
36MP0010307_abnormal_tumor_latency1.75731205
37MP0003191_abnormal_cellular_cholesterol1.74696329
38MP0002452_abnormal_antigen_presenting1.71962649
39MP0002148_abnormal_hypersensitivity_rea1.71545281
40MP0002396_abnormal_hematopoietic_system1.71175497
41MP0001730_embryonic_growth_arrest1.69980581
42MP0004264_abnormal_extraembryonic_tissu1.67413427
43MP0002420_abnormal_adaptive_immunity1.66943761
44MP0003252_abnormal_bile_duct1.65452221
45MP0001819_abnormal_immune_cell1.64966261
46MP0005666_abnormal_adipose_tissue1.59080025
47MP0010329_abnormal_lipoprotein_level1.58784696
48MP0001533_abnormal_skeleton_physiology1.57957795
49MP0000609_abnormal_liver_physiology1.57424392
50MP0000465_gastrointestinal_hemorrhage1.57222134
51MP0001853_heart_inflammation1.56967946
52MP0002009_preneoplasia1.56931198
53MP0008057_abnormal_DNA_replication1.56283158
54MP0003646_muscle_fatigue1.56106676
55MP0005670_abnormal_white_adipose1.54517566
56MP0002332_abnormal_exercise_endurance1.48880959
57MP0001849_ear_inflammation1.45258325
58MP0002405_respiratory_system_inflammati1.43991556
59MP0000350_abnormal_cell_proliferation1.40548345
60MP0004036_abnormal_muscle_relaxation1.39415198
61MP0001851_eye_inflammation1.39137729
62MP0005397_hematopoietic_system_phenotyp1.36114458
63MP0001545_abnormal_hematopoietic_system1.36114458
64MP0002877_abnormal_melanocyte_morpholog1.34621800
65MP0003656_abnormal_erythrocyte_physiolo1.31342558
66MP0004233_abnormal_muscle_weight1.30261017
67MP0000703_abnormal_thymus_morphology1.29391565
68MP0000490_abnormal_crypts_of1.27948499
69MP0004084_abnormal_cardiac_muscle1.27534271
70MP0003566_abnormal_cell_adhesion1.27199449
71MP0002086_abnormal_extraembryonic_tissu1.26720436
72MP0008961_abnormal_basal_metabolism1.25904613
73MP0002166_altered_tumor_susceptibility1.24214810
74MP0002019_abnormal_tumor_incidence1.23498262
75MP0004510_myositis1.22410553
76MP0001672_abnormal_embryogenesis/_devel1.20957836
77MP0005380_embryogenesis_phenotype1.20957836
78MP0008469_abnormal_protein_level1.20781993
79MP0003011_delayed_dark_adaptation1.18989994
80MP0005023_abnormal_wound_healing1.17887844
81MP0003075_altered_response_to1.16286844
82MP0002088_abnormal_embryonic_growth/wei1.16174113
83MP0003984_embryonic_growth_retardation1.15799734
84MP0005334_abnormal_fat_pad1.14812758
85MP0004808_abnormal_hematopoietic_stem1.12876471
86MP0002998_abnormal_bone_remodeling1.12694388
87MP0005647_abnormal_sex_gland1.11965809
88MP0008007_abnormal_cellular_replicative1.11750203
89MP0004947_skin_inflammation1.11282561
90MP0001697_abnormal_embryo_size1.09609629
91MP0009643_abnormal_urine_homeostasis1.09395995
92MP0001873_stomach_inflammation1.09376187
93MP0004883_abnormal_blood_vessel1.07683473
94MP0005332_abnormal_amino_acid1.07433351
95MP0004197_abnormal_fetal_growth/weight/1.06854307
96MP0000598_abnormal_liver_morphology1.06216735
97MP0002080_prenatal_lethality1.05511264
98MP0002722_abnormal_immune_system1.05299254
99MP0001666_abnormal_nutrient_absorption1.04780210
100MP0000751_myopathy1.04448540
101MP0002084_abnormal_developmental_patter1.03391450
102MP0005330_cardiomyopathy1.01626362
103MP0009672_abnormal_birth_weight1.00729133
104MP0005451_abnormal_body_composition1.00355217
105MP0010155_abnormal_intestine_physiology0.99936815
106MP0004087_abnormal_muscle_fiber0.99527931
107MP0002398_abnormal_bone_marrow0.99460759
108MP0009763_increased_sensitivity_to0.99456362
109MP0005375_adipose_tissue_phenotype0.98799382
110MP0005319_abnormal_enzyme/_coenzyme0.98763036
111MP0009764_decreased_sensitivity_to0.98273312
112MP0002006_tumorigenesis0.97397971
113MP0005164_abnormal_response_to0.97139384
114MP0004145_abnormal_muscle_electrophysio0.95653564
115MP0002970_abnormal_white_adipose0.95171418
116MP0004130_abnormal_muscle_cell0.94656505
117MP0002085_abnormal_embryonic_tissue0.93999066
118MP0006138_congestive_heart_failure0.92125746
119MP0000689_abnormal_spleen_morphology0.91856477
120MP0003045_fibrosis0.91583293
121MP0001915_intracranial_hemorrhage0.90601360
122MP0005464_abnormal_platelet_physiology0.89606125
123MP0000477_abnormal_intestine_morphology0.89555255
124MP0005310_abnormal_salivary_gland0.89542048
125MP0002933_joint_inflammation0.89260007
126MP0001919_abnormal_reproductive_system0.88234706
127MP0006082_CNS_inflammation0.88227034
128MP0002132_abnormal_respiratory_system0.87308979
129MP0000685_abnormal_immune_system0.86963267
130MP0000249_abnormal_blood_vessel0.84408176
131MP0000858_altered_metastatic_potential0.83722125
132MP0005535_abnormal_body_temperature0.82590294
133MP0009333_abnormal_splenocyte_physiolog0.82146147
134MP0010630_abnormal_cardiac_muscle0.81501848
135MP0002118_abnormal_lipid_homeostasis0.80750990
136MP0005166_decreased_susceptibility_to0.80513963
137MP0005220_abnormal_exocrine_pancreas0.80146359
138MP0002106_abnormal_muscle_physiology0.79784164
139MP0003866_abnormal_defecation0.79603046
140MP0003303_peritoneal_inflammation0.79334060
141MP0003699_abnormal_female_reproductive0.78469453
142MP0008058_abnormal_DNA_repair0.76848000
143MP0004019_abnormal_vitamin_homeostasis0.76130748
144MP0002269_muscular_atrophy0.75888734
145MP0003453_abnormal_keratinocyte_physiol0.75552246
146MP0002138_abnormal_hepatobiliary_system0.74236073
147MP0000313_abnormal_cell_death0.73176715
148MP0002429_abnormal_blood_cell0.72169145
149MP0009115_abnormal_fat_cell0.70708380
150MP0000716_abnormal_immune_system0.69561246
151MP0008877_abnormal_DNA_methylation0.68512312
152MP0002971_abnormal_brown_adipose0.68010073
153MP0001845_abnormal_inflammatory_respons0.67246130
154MP0002136_abnormal_kidney_physiology0.66754086
155MP0002796_impaired_skin_barrier0.65584935
156MP0006054_spinal_hemorrhage0.64954701
157MP0005408_hypopigmentation0.64740522

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.05258386
2Nemaline bodies (HP:0003798)3.80264451
3Exercise-induced myalgia (HP:0003738)3.79481976
4Muscle fiber inclusion bodies (HP:0100299)3.76777779
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.70597473
6Deep venous thrombosis (HP:0002625)3.68188353
7Myositis (HP:0100614)3.66874119
8Elevated erythrocyte sedimentation rate (HP:0003565)3.42087443
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33821213
10Orchitis (HP:0100796)3.29414128
11T lymphocytopenia (HP:0005403)3.27110675
12Recurrent gram-negative bacterial infections (HP:0005420)3.19911538
13Centrally nucleated skeletal muscle fibers (HP:0003687)3.11398498
14Gastrointestinal infarctions (HP:0005244)3.10545809
15Ependymoma (HP:0002888)3.04693077
16Recurrent abscess formation (HP:0002722)2.98512806
17Abnormality of T cell number (HP:0011839)2.96534944
18Increased IgE level (HP:0003212)2.93112229
19Retrobulbar optic neuritis (HP:0100654)2.90836785
20Optic neuritis (HP:0100653)2.90836785
21Stomatitis (HP:0010280)2.87340928
22Asymmetric septal hypertrophy (HP:0001670)2.83869347
23Mediastinal lymphadenopathy (HP:0100721)2.82124455
24Autoimmune hemolytic anemia (HP:0001890)2.79904269
25Hyporeflexia of lower limbs (HP:0002600)2.78654731
26Recurrent fungal infections (HP:0002841)2.74572602
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.70040641
28Meningitis (HP:0001287)2.69784305
29Spontaneous hematomas (HP:0007420)2.68381281
30Abnormality of skeletal muscle fiber size (HP:0012084)2.67626626
31Recurrent bacterial skin infections (HP:0005406)2.67000558
32Prolonged bleeding time (HP:0003010)2.66038677
33Complement deficiency (HP:0004431)2.65781719
34Abnormality of pyrimidine metabolism (HP:0004353)2.65155034
35Muscle fiber splitting (HP:0003555)2.63185154
36Spastic diplegia (HP:0001264)2.63091384
37Hypobetalipoproteinemia (HP:0003563)2.61103251
38Pseudobulbar signs (HP:0002200)2.59654324
39EMG: myopathic abnormalities (HP:0003458)2.59603280
40Abnormality of the fingertips (HP:0001211)2.56811545
41Increased connective tissue (HP:0009025)2.55505948
42Intrahepatic cholestasis (HP:0001406)2.53628459
43Type 1 muscle fiber predominance (HP:0003803)2.53551279
44Myoglobinuria (HP:0002913)2.52821243
45Arterial thrombosis (HP:0004420)2.52650992
46Combined immunodeficiency (HP:0005387)2.52317313
47Subaortic stenosis (HP:0001682)2.49397872
48Abnormality of the left ventricular outflow tract (HP:0011103)2.49397872
49Xanthomatosis (HP:0000991)2.47686616
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.45909697
51Systemic lupus erythematosus (HP:0002725)2.45341644
52Keratoconjunctivitis sicca (HP:0001097)2.43119107
53Distal lower limb muscle weakness (HP:0009053)2.42580105
54Abnormality of macrophages (HP:0004311)2.41216554
55Hypoplasia of the thymus (HP:0000778)2.40321625
56Epistaxis (HP:0000421)2.39703172
57Acute hepatic failure (HP:0006554)2.39037350
58Colitis (HP:0002583)2.37864567
59Hyperammonemia (HP:0001987)2.37483506
60Vasculitis (HP:0002633)2.36862955
61Agammaglobulinemia (HP:0004432)2.36513339
62Chest pain (HP:0100749)2.35688216
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34007813
64Polycythemia (HP:0001901)2.33791095
65Cellulitis (HP:0100658)2.30626622
66Fatigue (HP:0012378)2.30483021
67Hypoglycemic coma (HP:0001325)2.28550377
68Encephalitis (HP:0002383)2.28530509
69Enlarged penis (HP:0000040)2.26249831
70Gingival bleeding (HP:0000225)2.23815636
71Rhabdomyosarcoma (HP:0002859)2.23167842
72Rectal prolapse (HP:0002035)2.22175505
73Neck muscle weakness (HP:0000467)2.21773611
74Multiple enchondromatosis (HP:0005701)2.21740060
75Abnormality of B cell number (HP:0010975)2.21005819
76B lymphocytopenia (HP:0010976)2.21005819
77Increased variability in muscle fiber diameter (HP:0003557)2.20973100
78Abnormality of T cells (HP:0002843)2.20781134
79Osteomyelitis (HP:0002754)2.20667723
80Pulmonary infiltrates (HP:0002113)2.20107840
81Inflammation of the large intestine (HP:0002037)2.19608357
82Chronic mucocutaneous candidiasis (HP:0002728)2.18378546
83Recurrent cutaneous fungal infections (HP:0011370)2.18378546
84Gastrointestinal inflammation (HP:0004386)2.18361334
85Ulnar deviation of the wrist (HP:0003049)2.18197882
86Obstructive lung disease (HP:0006536)2.17934516
87Chronic obstructive pulmonary disease (HP:0006510)2.17934516
88Increased IgM level (HP:0003496)2.17807344
89Hypolipoproteinemia (HP:0010981)2.16617718
90Recurrent skin infections (HP:0001581)2.16200631
91Distal lower limb amyotrophy (HP:0008944)2.15893930
92Keratoconjunctivitis (HP:0001096)2.15648317
93Ketosis (HP:0001946)2.15221486
94Recurrent viral infections (HP:0004429)2.14325733
95Hyperglycinuria (HP:0003108)2.13007457
96Abnormality of complement system (HP:0005339)2.12802884
97Abnormality of nucleobase metabolism (HP:0010932)2.12750323
98Myopathic facies (HP:0002058)2.12454256
99Difficulty running (HP:0009046)2.12432403
100Gonadotropin excess (HP:0000837)2.11908108
101Biliary tract neoplasm (HP:0100574)2.10988020
102Late onset (HP:0003584)2.09695581
103Glomerulonephritis (HP:0000099)2.08993525
104Joint swelling (HP:0001386)2.08025587
105Gingivitis (HP:0000230)2.07749316
106Leukocytosis (HP:0001974)2.07570248
107Hypoalphalipoproteinemia (HP:0003233)2.06049228
108Abnormality of the common coagulation pathway (HP:0010990)2.05554277
109Pulmonary embolism (HP:0002204)2.03896735
110Back pain (HP:0003418)2.03640902
111Abnormality of T cell physiology (HP:0011840)2.03066302
112Abnormality of glutamine family amino acid metabolism (HP:0010902)2.01524167
113Gangrene (HP:0100758)2.01326701
114Male infertility (HP:0003251)2.00829835
115Epidermoid cyst (HP:0200040)2.00110153
116Seborrheic dermatitis (HP:0001051)1.98847901
117Bundle branch block (HP:0011710)1.98193816
118Sudden death (HP:0001699)1.97936244
119Astrocytoma (HP:0009592)1.97233037
120Abnormality of the astrocytes (HP:0100707)1.97233037
121Basal cell carcinoma (HP:0002671)1.96357370
122Skin rash (HP:0000988)1.95898705
123Urticaria (HP:0001025)1.95224252
124Severe combined immunodeficiency (HP:0004430)1.94282266
125Amyloidosis (HP:0011034)1.91932321
126Hemoptysis (HP:0002105)1.91422761
127Right ventricular cardiomyopathy (HP:0011663)1.91299767
128Insulin resistance (HP:0000855)1.91211049
129Papilloma (HP:0012740)1.90988611
130Verrucae (HP:0200043)1.90988611
131Limb hypertonia (HP:0002509)1.90300959
132Abnormal cartilage morphology (HP:0002763)1.90133763
133Neoplasm of striated muscle (HP:0009728)1.89796155
134Esophageal varix (HP:0002040)1.89737159
135Hyperacusis (HP:0010780)1.88840676
136Abnormality of the calcaneus (HP:0008364)1.88355085
137Sandal gap (HP:0001852)1.86794785
138Abnormality of purine metabolism (HP:0004352)1.86547968
139Muscle stiffness (HP:0003552)1.85864761
140Abnormal platelet volume (HP:0011876)1.85194588
141Abnormality of endocrine pancreas physiology (HP:0012093)1.84529364
142Abnormality of the pancreatic islet cells (HP:0006476)1.84529364
143Cerebral palsy (HP:0100021)1.84116069
144Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83662177
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82863068
146Lymphangioma (HP:0100764)1.82341272
147Increased mean platelet volume (HP:0011877)1.81468574
148Increased serum ferritin (HP:0003281)1.80696722
149Thrombocytosis (HP:0001894)1.80265981
150Acne (HP:0001061)1.80257681
151High pitched voice (HP:0001620)1.79265643
152Deviation of the thumb (HP:0009603)1.79118634
153Slow saccadic eye movements (HP:0000514)1.78833595
154Abnormality of glycine metabolism (HP:0010895)1.78795638
155Abnormality of serine family amino acid metabolism (HP:0010894)1.78795638
156Heterotopia (HP:0002282)1.77997669
157Adenoma sebaceum (HP:0009720)1.77658733
158Angiofibromas (HP:0010615)1.77658733
159Abnormality of iron homeostasis (HP:0011031)1.77629033
160Eosinophilia (HP:0001880)1.77418094
161Volvulus (HP:0002580)1.77188967
162Facial hemangioma (HP:0000329)1.76857566
163Proximal placement of thumb (HP:0009623)1.75756029
164Increased nuchal translucency (HP:0010880)1.74976434
165Cerebral aneurysm (HP:0004944)1.74347290
166Ketoacidosis (HP:0001993)1.73863029
167Metaphyseal cupping (HP:0003021)1.73183751
168Cortical dysplasia (HP:0002539)1.72031048
169Aneurysm (HP:0002617)1.70858003
170Panhypogammaglobulinemia (HP:0003139)1.70620837
171Gout (HP:0001997)1.69407364
172Premature ovarian failure (HP:0008209)1.67452481
173Malnutrition (HP:0004395)1.67213386
174Overlapping toe (HP:0001845)1.65732969
175Neoplasm of the oral cavity (HP:0100649)1.65018449
176Amaurosis fugax (HP:0100576)1.64514922
177Hyperglycemia (HP:0003074)1.63671839
178Broad palm (HP:0001169)1.63202605
179Medulloblastoma (HP:0002885)1.63137760
180Ovarian neoplasm (HP:0100615)1.61300314
181Abnormal biliary tract morphology (HP:0012440)1.61181806
182Rhabdomyolysis (HP:0003201)1.60813832
183Thrombophlebitis (HP:0004418)1.60665768
184Abnormality of methionine metabolism (HP:0010901)1.60068809
185Pancreatic islet-cell hyperplasia (HP:0004510)1.59091497
186Granulocytopenia (HP:0001913)1.59061486
187Myocardial infarction (HP:0001658)1.57678018
188Thyroiditis (HP:0100646)1.57003136
189Hepatocellular carcinoma (HP:0001402)1.56710232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.94413993
2PRPF4B4.45686188
3PKN24.01228494
4TRIB33.81092949
5RIPK43.39083928
6CDK123.05140994
7CDC72.88166825
8NEK22.32657248
9STK102.28583277
10MAP3K102.24823162
11MAP3K132.22378129
12RPS6KB22.19070372
13MAP3K142.17534540
14JAK12.07162152
15OBSCN1.97146067
16TTK1.86613920
17NEK11.84664554
18ERN11.77849600
19PTK61.75515578
20CDK41.72577506
21TAOK31.71936050
22FES1.67953870
23FLT31.67616471
24MAP4K11.63697646
25BLK1.60415276
26MAPKAPK31.54305817
27CDK61.53545457
28LATS11.53206484
29PASK1.51716568
30SCYL21.51456946
31TAOK21.50894242
32LRRK21.43838345
33GRK61.40993998
34FGFR41.35457828
35MAP3K81.34026573
36IRAK41.32865344
37SYK1.30025626
38TBK11.25737305
39CDK71.22568767
40MAP3K61.22275555
41BCKDK1.21120862
42KIT1.17012602
43WEE11.17005209
44MAPK121.15080348
45EPHA31.12385047
46ZAP701.11501840
47MAP3K11.10543401
48IKBKE1.09078764
49SMG11.07767453
50ICK1.05753340
51TEC1.05041629
52TSSK61.04839649
53MAPK111.04332480
54KSR21.04021216
55PAK41.01914949
56MTOR1.01471337
57MAP2K31.00155576
58TTN0.98984479
59PDGFRA0.97301080
60ALK0.96259242
61JAK30.93450946
62CLK10.92501573
63STK30.92323940
64SIK10.88267444
65PIM10.87716216
66CDK90.85916718
67AURKB0.85303488
68CDC42BPA0.84955570
69PDK10.84664512
70IRAK10.84000418
71MAP3K70.83162010
72TYK20.83090187
73PRKAA20.82806328
74JAK20.82773754
75ATR0.82750535
76MELK0.82042257
77MAPK70.81909505
78ITK0.81717348
79TGFBR10.81402413
80MOS0.77969248
81PLK10.76660409
82FRK0.75097612
83DMPK0.74803416
84CHEK10.74565178
85TAOK10.73694438
86FGFR30.73170870
87CSK0.72748194
88IKBKB0.70059817
89LYN0.68828978
90RIPK10.67957484
91RET0.66327705
92PDGFRB0.65503871
93PDPK10.65396437
94BMPR20.63666170
95EPHA20.62572209
96BUB10.61961317
97STK40.61555274
98TESK20.60889802
99ATM0.60743780
100CHEK20.59021104
101MAP2K20.59004738
102RPS6KA40.58893590
103BRD40.58161990
104SGK30.57707509
105CDK20.56752855
106HIPK20.56744526
107MAP3K50.55939642
108WNK10.53790887
109PAK20.53515288
110MARK20.51570904
111TYRO30.51481196
112RAF10.50782195
113TXK0.50581844
114TGFBR20.48639222
115BRSK20.48613373
116MAPK30.47581516
117BTK0.47038134
118EPHB10.46260050
119YES10.46008602
120MAPK40.44959662
121MAPKAPK20.44456021
122PIK3CG0.44336069
123RPS6KL10.44000388
124RPS6KC10.44000388
125BMX0.43870593
126TNK20.43478277
127PDK20.43429139
128ERBB40.42746074
129FGR0.42093650
130IRAK30.41773270
131NLK0.38912625
132CSF1R0.38786852
133CAMK1G0.38221730
134MARK30.37909216
135CAMK1D0.37868010
136NEK90.36230856
137LATS20.34293018
138RPS6KA10.33513981
139CDK10.33059643
140TRPM70.30043706
141AKT20.29938654
142HCK0.29334291
143CSNK1D0.28887066
144LCK0.28797484
145MAP3K30.28276772
146AURKA0.27872218
147ACVR1B0.27787611

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.83298032
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46980688
3DNA replication_Homo sapiens_hsa030302.46410286
4One carbon pool by folate_Homo sapiens_hsa006702.45000863
5Leishmaniasis_Homo sapiens_hsa051402.38325339
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26803052
7Arginine biosynthesis_Homo sapiens_hsa002202.19339962
8Osteoclast differentiation_Homo sapiens_hsa043802.18611149
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14800946
10Selenocompound metabolism_Homo sapiens_hsa004502.09686989
11Mismatch repair_Homo sapiens_hsa034301.91343639
12Biosynthesis of amino acids_Homo sapiens_hsa012301.91183580
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.87864750
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87556419
15B cell receptor signaling pathway_Homo sapiens_hsa046621.85876502
16Allograft rejection_Homo sapiens_hsa053301.81940816
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76944234
18Fatty acid degradation_Homo sapiens_hsa000711.72940781
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.68775321
20Measles_Homo sapiens_hsa051621.66370374
21Autoimmune thyroid disease_Homo sapiens_hsa053201.66212615
22Lysine degradation_Homo sapiens_hsa003101.65249751
23Non-homologous end-joining_Homo sapiens_hsa034501.61504964
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.60439549
25Viral myocarditis_Homo sapiens_hsa054161.60348986
26Graft-versus-host disease_Homo sapiens_hsa053321.59462196
27Hematopoietic cell lineage_Homo sapiens_hsa046401.58905741
28Cell cycle_Homo sapiens_hsa041101.58304704
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55596451
30Malaria_Homo sapiens_hsa051441.54328102
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52728344
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.50131907
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.48822149
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48564879
35Tryptophan metabolism_Homo sapiens_hsa003801.48524969
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.47178605
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45742485
38Toxoplasmosis_Homo sapiens_hsa051451.43987765
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42454421
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41949649
41Tuberculosis_Homo sapiens_hsa051521.41428736
42Carbon metabolism_Homo sapiens_hsa012001.40732956
43Influenza A_Homo sapiens_hsa051641.37503614
44RNA transport_Homo sapiens_hsa030131.33854415
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33598698
46Base excision repair_Homo sapiens_hsa034101.29033096
47PPAR signaling pathway_Homo sapiens_hsa033201.28147631
48Pentose phosphate pathway_Homo sapiens_hsa000301.26943707
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24031952
50Complement and coagulation cascades_Homo sapiens_hsa046101.23405468
51TNF signaling pathway_Homo sapiens_hsa046681.22149122
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.19745939
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18242067
54Fatty acid metabolism_Homo sapiens_hsa012121.17589438
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15064022
56Platelet activation_Homo sapiens_hsa046111.13880723
57Thyroid cancer_Homo sapiens_hsa052161.13694000
58Legionellosis_Homo sapiens_hsa051341.13205907
59Staphylococcus aureus infection_Homo sapiens_hsa051501.13083096
60Caffeine metabolism_Homo sapiens_hsa002321.13066319
61Propanoate metabolism_Homo sapiens_hsa006401.07751841
62Asthma_Homo sapiens_hsa053101.07695951
63Chronic myeloid leukemia_Homo sapiens_hsa052201.06648767
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05839159
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05668331
66Pertussis_Homo sapiens_hsa051331.04340603
67Hepatitis C_Homo sapiens_hsa051601.04024104
68Pyruvate metabolism_Homo sapiens_hsa006201.02715349
69Primary immunodeficiency_Homo sapiens_hsa053401.02303027
70Spliceosome_Homo sapiens_hsa030401.00494523
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00348104
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99256348
73Other glycan degradation_Homo sapiens_hsa005110.97672644
74mRNA surveillance pathway_Homo sapiens_hsa030150.96283557
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95339956
76VEGF signaling pathway_Homo sapiens_hsa043700.90786257
77Type I diabetes mellitus_Homo sapiens_hsa049400.89335645
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.88723077
79Antigen processing and presentation_Homo sapiens_hsa046120.88047145
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87607279
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.87287006
82Acute myeloid leukemia_Homo sapiens_hsa052210.86927946
83Chemokine signaling pathway_Homo sapiens_hsa040620.85552422
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84094957
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.83814638
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83638371
87mTOR signaling pathway_Homo sapiens_hsa041500.83104396
88Sulfur relay system_Homo sapiens_hsa041220.82745059
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81593628
90Circadian rhythm_Homo sapiens_hsa047100.80681020
91Nucleotide excision repair_Homo sapiens_hsa034200.78571926
92Folate biosynthesis_Homo sapiens_hsa007900.77695650
93Apoptosis_Homo sapiens_hsa042100.77137676
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76953746
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76632876
96Shigellosis_Homo sapiens_hsa051310.76625140
97Insulin resistance_Homo sapiens_hsa049310.76473473
98beta-Alanine metabolism_Homo sapiens_hsa004100.75577505
99FoxO signaling pathway_Homo sapiens_hsa040680.75238066
100Amoebiasis_Homo sapiens_hsa051460.74149388
101Starch and sucrose metabolism_Homo sapiens_hsa005000.73364886
102Bile secretion_Homo sapiens_hsa049760.73118443
103Non-small cell lung cancer_Homo sapiens_hsa052230.72120334
104Fat digestion and absorption_Homo sapiens_hsa049750.71376384
105RNA degradation_Homo sapiens_hsa030180.71228085
106MicroRNAs in cancer_Homo sapiens_hsa052060.70333923
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.67415021
108Pancreatic cancer_Homo sapiens_hsa052120.67237471
109Renal cell carcinoma_Homo sapiens_hsa052110.67197029
110Notch signaling pathway_Homo sapiens_hsa043300.66639194
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64848791
112Homologous recombination_Homo sapiens_hsa034400.64737617
113Peroxisome_Homo sapiens_hsa041460.64702380
114Adherens junction_Homo sapiens_hsa045200.63671580
115Ovarian steroidogenesis_Homo sapiens_hsa049130.63476178
116Small cell lung cancer_Homo sapiens_hsa052220.63206135
117Sulfur metabolism_Homo sapiens_hsa009200.63048548
118Colorectal cancer_Homo sapiens_hsa052100.62784795
119Butanoate metabolism_Homo sapiens_hsa006500.62766609
120T cell receptor signaling pathway_Homo sapiens_hsa046600.62400190
121Fatty acid biosynthesis_Homo sapiens_hsa000610.61704876
122AMPK signaling pathway_Homo sapiens_hsa041520.61260435
123Viral carcinogenesis_Homo sapiens_hsa052030.60309017
124p53 signaling pathway_Homo sapiens_hsa041150.60070620
125HTLV-I infection_Homo sapiens_hsa051660.58529626
126African trypanosomiasis_Homo sapiens_hsa051430.58433814
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56950088
128ABC transporters_Homo sapiens_hsa020100.56434020
129Endometrial cancer_Homo sapiens_hsa052130.56277013
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53309139
131HIF-1 signaling pathway_Homo sapiens_hsa040660.53120899
132Prion diseases_Homo sapiens_hsa050200.51948000
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51830331
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51813196
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.51490247
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51204601
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.50010360
138Arachidonic acid metabolism_Homo sapiens_hsa005900.49483763
139Prolactin signaling pathway_Homo sapiens_hsa049170.49249713
140Bladder cancer_Homo sapiens_hsa052190.48979972
141Phenylalanine metabolism_Homo sapiens_hsa003600.48234716
142Arginine and proline metabolism_Homo sapiens_hsa003300.47024406
143Glycerolipid metabolism_Homo sapiens_hsa005610.46822119
144Choline metabolism in cancer_Homo sapiens_hsa052310.45885538
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.45021777
146Prostate cancer_Homo sapiens_hsa052150.44591254
147Tyrosine metabolism_Homo sapiens_hsa003500.44421609
148Glucagon signaling pathway_Homo sapiens_hsa049220.43438194
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41610401
150Insulin signaling pathway_Homo sapiens_hsa049100.41344641
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.41185337
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41167017
153Histidine metabolism_Homo sapiens_hsa003400.41098764
154Herpes simplex infection_Homo sapiens_hsa051680.40976745
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.39731261
156Chemical carcinogenesis_Homo sapiens_hsa052040.39118565
157Hepatitis B_Homo sapiens_hsa051610.38871060
158Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38419683

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