FKBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.12737445
2folic acid-containing compound biosynthetic process (GO:0009396)4.81614785
3nucleobase biosynthetic process (GO:0046112)4.59457877
4Golgi transport vesicle coating (GO:0048200)4.52402579
5COPI coating of Golgi vesicle (GO:0048205)4.52402579
6proline biosynthetic process (GO:0006561)4.49626546
7DNA strand elongation involved in DNA replication (GO:0006271)4.47274464
8DNA replication initiation (GO:0006270)4.39440893
9DNA replication-dependent nucleosome assembly (GO:0006335)4.33774450
10DNA replication-dependent nucleosome organization (GO:0034723)4.33774450
11formation of translation preinitiation complex (GO:0001731)4.27896059
12DNA strand elongation (GO:0022616)4.21891326
13purine nucleobase biosynthetic process (GO:0009113)4.20043912
14IMP biosynthetic process (GO:0006188)4.18073958
15protein localization to kinetochore (GO:0034501)3.91006722
16mitotic nuclear envelope disassembly (GO:0007077)3.89480357
17maturation of SSU-rRNA (GO:0030490)3.88880744
18DNA deamination (GO:0045006)3.86504675
19telomere maintenance via semi-conservative replication (GO:0032201)3.86023858
20nuclear pore organization (GO:0006999)3.81468792
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.81340287
22ribosome assembly (GO:0042255)3.77729246
23cellular protein complex localization (GO:0034629)3.77016101
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.72315076
25nuclear envelope disassembly (GO:0051081)3.63186963
26membrane disassembly (GO:0030397)3.63186963
27IMP metabolic process (GO:0046040)3.61001068
28DNA replication checkpoint (GO:0000076)3.60889856
29folic acid metabolic process (GO:0046655)3.59408846
30nucleobase-containing small molecule interconversion (GO:0015949)3.59264782
31regulation of gene silencing by RNA (GO:0060966)3.58053045
32regulation of posttranscriptional gene silencing (GO:0060147)3.58053045
33regulation of gene silencing by miRNA (GO:0060964)3.58053045
34viral transcription (GO:0019083)3.57790655
35ribosome biogenesis (GO:0042254)3.57135825
36translational termination (GO:0006415)3.54759342
37pore complex assembly (GO:0046931)3.49123263
38mitotic metaphase plate congression (GO:0007080)3.48137573
39regulation of translational fidelity (GO:0006450)3.47863765
40translational elongation (GO:0006414)3.46884095
41nuclear pore complex assembly (GO:0051292)3.46169700
42ribosomal small subunit assembly (GO:0000028)3.42469010
43translational initiation (GO:0006413)3.41585383
44ribosomal large subunit biogenesis (GO:0042273)3.40038693
45ribonucleoprotein complex biogenesis (GO:0022613)3.35895991
46* protein complex localization (GO:0031503)3.35788491
47spliceosomal snRNP assembly (GO:0000387)3.35628294
48protein localization to chromosome, centromeric region (GO:0071459)3.34704461
49DNA duplex unwinding (GO:0032508)3.34475667
50regulation of translational termination (GO:0006449)3.34052226
51protein-DNA complex disassembly (GO:0032986)3.32215202
52nucleosome disassembly (GO:0006337)3.32215202
53DNA geometric change (GO:0032392)3.32085873
54telomere maintenance via recombination (GO:0000722)3.29047541
55peptidyl-arginine omega-N-methylation (GO:0035247)3.24863648
56protein retention in ER lumen (GO:0006621)3.24713426
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23563758
58chaperone-mediated protein complex assembly (GO:0051131)3.22183652
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21999722
60pteridine-containing compound biosynthetic process (GO:0042559)3.21862662
61mitotic recombination (GO:0006312)3.19178778
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19075669
63telomere maintenance via telomere lengthening (GO:0010833)3.16908082
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14884544
65mitotic sister chromatid cohesion (GO:0007064)3.13965166
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.12685572
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12685572
68peptidyl-arginine N-methylation (GO:0035246)3.12013433
69peptidyl-arginine methylation (GO:0018216)3.12013433
70rRNA transcription (GO:0009303)3.11907017
71heterochromatin organization (GO:0070828)3.11712742
72histone arginine methylation (GO:0034969)3.09863003
73ribosomal small subunit biogenesis (GO:0042274)3.05796240
74metaphase plate congression (GO:0051310)3.04482794
75mitotic sister chromatid segregation (GO:0000070)3.04290097
76proline metabolic process (GO:0006560)3.01045651
77maternal placenta development (GO:0001893)2.99868200
78protein export from nucleus (GO:0006611)2.99229584
79rRNA processing (GO:0006364)2.99047957
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.98307005
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98159298
82establishment of integrated proviral latency (GO:0075713)2.97872290
83pre-miRNA processing (GO:0031054)2.95810416
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95754236
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95283874
86mRNA stabilization (GO:0048255)2.95032374
87RNA stabilization (GO:0043489)2.95032374
88glycine metabolic process (GO:0006544)2.94922255
89regulation of translational elongation (GO:0006448)2.94016699
90tRNA aminoacylation for protein translation (GO:0006418)2.93244064
91negative regulation of RNA splicing (GO:0033119)2.92614002
92tetrahydrofolate metabolic process (GO:0046653)2.91518932
93rRNA metabolic process (GO:0016072)2.90428532
94negative regulation of chromosome segregation (GO:0051985)2.90303741
95chromatin remodeling at centromere (GO:0031055)2.90066446
96protein targeting to ER (GO:0045047)2.88660570
97regulation of RNA export from nucleus (GO:0046831)2.88625609
98mitotic chromosome condensation (GO:0007076)2.88489351
99L-serine metabolic process (GO:0006563)2.87566261
100cotranslational protein targeting to membrane (GO:0006613)2.87339969
101translesion synthesis (GO:0019985)2.86904737
102nuclear envelope organization (GO:0006998)2.86339301
103regulation of histone H3-K9 methylation (GO:0051570)2.86181531
104chromosome condensation (GO:0030261)2.85098935
105cellular protein complex disassembly (GO:0043624)2.85012868
106tRNA aminoacylation (GO:0043039)2.84421338
107amino acid activation (GO:0043038)2.84421338
108negative regulation of sister chromatid segregation (GO:0033046)2.84307283
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.84307283
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84307283
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84307283
112paraxial mesoderm development (GO:0048339)2.84286453
113pseudouridine synthesis (GO:0001522)2.83975481
114DNA replication-independent nucleosome organization (GO:0034724)2.82945094
115DNA replication-independent nucleosome assembly (GO:0006336)2.82945094
116regulation of helicase activity (GO:0051095)2.82382141
117regulation of centrosome cycle (GO:0046605)2.81740298
118sister chromatid segregation (GO:0000819)2.81246640
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81011619
120mRNA splicing, via spliceosome (GO:0000398)2.81011619
121regulation of spindle organization (GO:0090224)2.80794792
122RNA splicing, via transesterification reactions (GO:0000375)2.79417274
123viral life cycle (GO:0019058)2.78356937
124postreplication repair (GO:0006301)2.78024063
125mitotic spindle assembly checkpoint (GO:0007094)2.78017310
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77969060
127negative regulation of mRNA processing (GO:0050686)2.77278074
128positive regulation of keratinocyte differentiation (GO:0045618)2.76668658
129DNA topological change (GO:0006265)2.76327470
130negative regulation of mRNA metabolic process (GO:1903312)2.75994378
131positive regulation of chromosome segregation (GO:0051984)2.71060784
132pentose-phosphate shunt (GO:0006098)2.70721464
133regulation of nucleobase-containing compound transport (GO:0032239)2.70471256
134regulation of mitotic spindle organization (GO:0060236)2.69814979
135mitotic nuclear envelope reassembly (GO:0007084)2.68867693
136nuclear envelope reassembly (GO:0031468)2.68867693
137adherens junction assembly (GO:0034333)2.66417467
138negative regulation of cell size (GO:0045792)2.65432871
139mitotic G1 DNA damage checkpoint (GO:0031571)2.64256467
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63402818
141establishment of viral latency (GO:0019043)2.62614896
142DNA conformation change (GO:0071103)2.62428277
143peptidyl-lysine dimethylation (GO:0018027)2.60032748
144viral mRNA export from host cell nucleus (GO:0046784)2.57297004
145desmosome organization (GO:0002934)2.55199509
146DNA synthesis involved in DNA repair (GO:0000731)2.52279988
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.51778613
148mitochondrial fusion (GO:0008053)2.48017798
149cell-substrate adherens junction assembly (GO:0007045)2.45445161
150focal adhesion assembly (GO:0048041)2.45445161
1513-UTR-mediated mRNA stabilization (GO:0070935)2.44515912
152protein maturation by protein folding (GO:0022417)2.44411709
153G1 DNA damage checkpoint (GO:0044783)2.44297899
154chromatin assembly (GO:0031497)2.43030340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27916801
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.32254617
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90348535
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.52006688
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12366971
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02113323
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85479373
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81431320
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77141132
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60518500
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.58344426
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48949482
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.46034057
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45981840
15XRN2_22483619_ChIP-Seq_HELA_Human2.40399201
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36197344
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34392881
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23555045
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.22429789
20AR_21909140_ChIP-Seq_LNCAP_Human2.05195501
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01695875
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.01566310
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99079631
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98169180
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87295239
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86343083
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86108597
28* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83036031
29GABP_19822575_ChIP-Seq_HepG2_Human1.80343586
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79729361
31VDR_23849224_ChIP-Seq_CD4+_Human1.79024768
32DCP1A_22483619_ChIP-Seq_HELA_Human1.77510868
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76149642
34* RACK7_27058665_Chip-Seq_MCF-7_Human1.74724832
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73011065
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.72330374
37TTF2_22483619_ChIP-Seq_HELA_Human1.70755300
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69504216
39MYC_22102868_ChIP-Seq_BL_Human1.67863729
40FOXP3_21729870_ChIP-Seq_TREG_Human1.66020931
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64288701
42CIITA_25753668_ChIP-Seq_RAJI_Human1.62200216
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57661333
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.57352080
45* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57186268
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56013146
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55753982
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55013315
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.54977227
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47159696
51LXR_22292898_ChIP-Seq_THP-1_Human1.46115991
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44985522
53* KDM5A_27292631_Chip-Seq_BREAST_Human1.44354894
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42487224
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40619139
56* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40252659
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39557094
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38086312
59* CLOCK_20551151_ChIP-Seq_293T_Human1.36065729
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36065122
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35523747
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33629669
63* CHD1_26751641_Chip-Seq_LNCaP_Human1.33625440
64* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31166241
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30964404
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30913109
67ZNF263_19887448_ChIP-Seq_K562_Human1.27220442
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26585874
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26178415
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26079065
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.25955849
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24569289
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.23084073
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22608350
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22563577
76* ESR2_21235772_ChIP-Seq_MCF-7_Human1.21875314
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21714831
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19785097
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19785097
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19785097
81* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19608055
82ATF3_27146783_Chip-Seq_COLON_Human1.16933660
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13686388
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12741385
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12066889
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.11625992
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11365162
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10396072
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10230086
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08178352
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07982951
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07962911
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07800169
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.07626049
95TFEB_21752829_ChIP-Seq_HELA_Human1.07618031
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07056153
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06902733
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06585105
99* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06540116
100* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06019704
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05543880
102P68_20966046_ChIP-Seq_HELA_Human1.04928797
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03933456
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03747413
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02672988
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02468283
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02381060
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.02092645
109CREB1_26743006_Chip-Seq_LNCaP_Human1.00807359
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00485096
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00279782
112* ESR1_20079471_ChIP-ChIP_T-47D_Human0.99289778
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98687715
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98529158
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97605642
116* TCF7_22412390_ChIP-Seq_EML_Mouse0.97154227
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96609361
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96275356
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95998546
120* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95695562
121ELK1_19687146_ChIP-ChIP_HELA_Human0.95582764
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95545188
123KDM2B_26808549_Chip-Seq_K562_Human0.95363079
124VDR_21846776_ChIP-Seq_THP-1_Human0.95362051
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95278986
126* KDM2B_26808549_Chip-Seq_DND41_Human0.95276503
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94919519
128ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93612228
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93352289
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92787887
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90171331
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90021477
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89986370
134* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89264204
135* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88782183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02942062
2MP0004957_abnormal_blastocyst_morpholog4.41489210
3MP0003111_abnormal_nucleus_morphology4.16190566
4MP0010094_abnormal_chromosome_stability4.03508714
5MP0003077_abnormal_cell_cycle3.57570276
6MP0008057_abnormal_DNA_replication3.01900304
7MP0001730_embryonic_growth_arrest2.76945269
8MP0003806_abnormal_nucleotide_metabolis2.73904734
9MP0008058_abnormal_DNA_repair2.71052328
10MP0002796_impaired_skin_barrier2.62991221
11MP0003123_paternal_imprinting2.59408701
12MP0010352_gastrointestinal_tract_polyps2.59108632
13MP0008932_abnormal_embryonic_tissue2.58003861
14MP0002877_abnormal_melanocyte_morpholog2.41780493
15MP0008007_abnormal_cellular_replicative2.40903876
16MP0004185_abnormal_adipocyte_glucose2.36749526
17MP0000350_abnormal_cell_proliferation2.21862676
18MP0001346_abnormal_lacrimal_gland2.21839384
19MP0005451_abnormal_body_composition2.21360878
20MP0002653_abnormal_ependyma_morphology2.12820799
21MP0010030_abnormal_orbit_morphology2.05886745
22MP0005380_embryogenesis_phenotype2.03052477
23MP0001672_abnormal_embryogenesis/_devel2.03052477
24MP0001697_abnormal_embryo_size1.98084694
25MP0000579_abnormal_nail_morphology1.92789541
26MP0008877_abnormal_DNA_methylation1.90088664
27MP0002084_abnormal_developmental_patter1.87200956
28MP0002085_abnormal_embryonic_tissue1.86909419
29* MP0002080_prenatal_lethality1.84466666
30MP0003984_embryonic_growth_retardation1.82269133
31MP0002088_abnormal_embryonic_growth/wei1.79722021
32MP0003890_abnormal_embryonic-extraembry1.76849514
33MP0003119_abnormal_digestive_system1.72047667
34MP0004197_abnormal_fetal_growth/weight/1.66965548
35MP0003786_premature_aging1.65583525
36MP0000566_synostosis1.62261108
37MP0004133_heterotaxia1.59879098
38MP0003567_abnormal_fetal_cardiomyocyte1.59542234
39MP0002098_abnormal_vibrissa_morphology1.57665604
40* MP0002086_abnormal_extraembryonic_tissu1.52534733
41MP0003283_abnormal_digestive_organ1.51896839
42MP0001881_abnormal_mammary_gland1.50519552
43MP0001293_anophthalmia1.44783995
44MP0010307_abnormal_tumor_latency1.44506401
45MP0004858_abnormal_nervous_system1.42633921
46MP0009053_abnormal_anal_canal1.39554560
47MP0000313_abnormal_cell_death1.34082155
48MP0002009_preneoplasia1.31171927
49MP0003705_abnormal_hypodermis_morpholog1.31040181
50MP0004782_abnormal_surfactant_physiolog1.30046521
51MP0005076_abnormal_cell_differentiation1.29875415
52MP0009672_abnormal_birth_weight1.27370005
53MP0000490_abnormal_crypts_of1.26756644
54MP0004233_abnormal_muscle_weight1.24964127
55MP0000358_abnormal_cell_content/1.24542711
56MP0002249_abnormal_larynx_morphology1.24292655
57MP0004264_abnormal_extraembryonic_tissu1.24029167
58MP0001849_ear_inflammation1.23562040
59MP0003718_maternal_effect1.22404987
60MP0003453_abnormal_keratinocyte_physiol1.22219629
61* MP0002210_abnormal_sex_determination1.21498352
62* MP0000627_abnormal_mammary_gland1.19976971
63* MP0001145_abnormal_male_reproductive1.19649886
64MP0000762_abnormal_tongue_morphology1.15793052
65MP0002396_abnormal_hematopoietic_system1.15670752
66MP0003221_abnormal_cardiomyocyte_apopto1.11524131
67* MP0001929_abnormal_gametogenesis1.11150017
68MP0005623_abnormal_meninges_morphology1.09997117
69MP0002019_abnormal_tumor_incidence1.09829229
70MP0000467_abnormal_esophagus_morphology1.07840485
71MP0000377_abnormal_hair_follicle1.06853581
72MP0001661_extended_life_span1.05913357
73MP0005409_darkened_coat_color1.04300468
74MP0001727_abnormal_embryo_implantation1.03178709
75MP0002269_muscular_atrophy1.03017666
76MP0006036_abnormal_mitochondrial_physio1.02102739
77MP0010678_abnormal_skin_adnexa1.01589386
78MP0003121_genomic_imprinting1.01498088
79MP0009840_abnormal_foam_cell1.00423070
80MP0004084_abnormal_cardiac_muscle0.99550024
81MP0002111_abnormal_tail_morphology0.99013113
82MP0001216_abnormal_epidermal_layer0.98378617
83MP0005058_abnormal_lysosome_morphology0.98105929
84MP0006035_abnormal_mitochondrial_morpho0.96398996
85MP0005666_abnormal_adipose_tissue0.95404214
86* MP0000537_abnormal_urethra_morphology0.94122001
87* MP0000653_abnormal_sex_gland0.93868105
88MP0000747_muscle_weakness0.93713236
89MP0008260_abnormal_autophagy0.90912167
90MP0005377_hearing/vestibular/ear_phenot0.89780554
91MP0003878_abnormal_ear_physiology0.89780554
92MP0002089_abnormal_postnatal_growth/wei0.89454273
93MP0000003_abnormal_adipose_tissue0.89186683
94MP0005266_abnormal_metabolism0.87935387
95MP0000428_abnormal_craniofacial_morphol0.87673836
96MP0009780_abnormal_chondrocyte_physiolo0.84371346
97MP0009703_decreased_birth_body0.83977489
98MP0000750_abnormal_muscle_regeneration0.83301221
99MP0000733_abnormal_muscle_development0.83025085
100MP0001348_abnormal_lacrimal_gland0.81784857
101MP0003186_abnormal_redox_activity0.80435705
102MP0002060_abnormal_skin_morphology0.80340964
103MP0010234_abnormal_vibrissa_follicle0.80094496
104MP0002092_abnormal_eye_morphology0.79189411
105MP0010771_integument_phenotype0.78717931
106MP0002254_reproductive_system_inflammat0.78700510
107MP0000678_abnormal_parathyroid_gland0.78543614
108MP0003937_abnormal_limbs/digits/tail_de0.78325712
109MP0002697_abnormal_eye_size0.77246223
110MP0005384_cellular_phenotype0.75173164
111MP0003566_abnormal_cell_adhesion0.75067485
112* MP0003698_abnormal_male_reproductive0.75047337
113MP0003941_abnormal_skin_development0.75031160
114MP0000477_abnormal_intestine_morphology0.73619368
115MP0005248_abnormal_Harderian_gland0.73516697
116MP0003115_abnormal_respiratory_system0.72492847
117MP0005375_adipose_tissue_phenotype0.72436534
118MP0005023_abnormal_wound_healing0.70611059
119MP0006054_spinal_hemorrhage0.69796423
120MP0009931_abnormal_skin_appearance0.69561610
121MP0004087_abnormal_muscle_fiber0.68746670
122MP0005501_abnormal_skin_physiology0.67975659
123MP0001340_abnormal_eyelid_morphology0.67688455
124MP0002234_abnormal_pharynx_morphology0.66737470
125MP0003861_abnormal_nervous_system0.64910969
126MP0004808_abnormal_hematopoietic_stem0.64058712
127MP0001286_abnormal_eye_development0.63623314
128MP0003646_muscle_fatigue0.62997656
129MP0010630_abnormal_cardiac_muscle0.61716326
130MP0005621_abnormal_cell_physiology0.60532907
131MP0005220_abnormal_exocrine_pancreas0.60493140
132MP0008770_decreased_survivor_rate0.60421107
133* MP0002161_abnormal_fertility/fecundity0.60259496
134MP0003942_abnormal_urinary_system0.59708201
135MP0005083_abnormal_biliary_tract0.58092864
136MP0001915_intracranial_hemorrhage0.57898634
137MP0000266_abnormal_heart_morphology0.57503049
138MP0000534_abnormal_ureter_morphology0.57373141
139MP0005330_cardiomyopathy0.56780183
140MP0003935_abnormal_craniofacial_develop0.56681296
141MP0000598_abnormal_liver_morphology0.55154366
142MP0000462_abnormal_digestive_system0.53300044

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.65675511
2Colon cancer (HP:0003003)3.84491090
3Selective tooth agenesis (HP:0001592)3.74725840
4Reticulocytopenia (HP:0001896)3.69779540
5Oral leukoplakia (HP:0002745)3.58784631
6Breast hypoplasia (HP:0003187)3.48144359
7Birth length less than 3rd percentile (HP:0003561)3.41818252
8Medulloblastoma (HP:0002885)3.36973460
9Abnormality of cells of the erythroid lineage (HP:0012130)3.35700885
10Multiple enchondromatosis (HP:0005701)3.22487375
11Degeneration of anterior horn cells (HP:0002398)3.16957317
12Abnormality of the anterior horn cell (HP:0006802)3.16957317
13Abnormal number of erythroid precursors (HP:0012131)3.11364714
14Carpal bone hypoplasia (HP:0001498)2.99912734
15Insomnia (HP:0100785)2.99267315
16Cerebral hypomyelination (HP:0006808)2.93489838
17Rhabdomyosarcoma (HP:0002859)2.91777389
18Astrocytoma (HP:0009592)2.91610364
19Abnormality of the astrocytes (HP:0100707)2.91610364
20Septate vagina (HP:0001153)2.87239789
21Sparse lateral eyebrow (HP:0005338)2.86744986
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80535993
23Asymmetry of the thorax (HP:0001555)2.74385144
24Angiofibromas (HP:0010615)2.72023732
25Adenoma sebaceum (HP:0009720)2.72023732
26Trismus (HP:0000211)2.69644026
27Neoplasm of the pancreas (HP:0002894)2.65773703
28Progressive muscle weakness (HP:0003323)2.64847361
29Patellar aplasia (HP:0006443)2.62653535
30Rough bone trabeculation (HP:0100670)2.60308391
31Progressive external ophthalmoplegia (HP:0000590)2.57274318
32Macrocytic anemia (HP:0001972)2.57101013
33Glioma (HP:0009733)2.51663250
34Dysmetric saccades (HP:0000641)2.51157044
35Aplasia/Hypoplasia of the patella (HP:0006498)2.50667212
36Microvesicular hepatic steatosis (HP:0001414)2.49002776
37Absent thumb (HP:0009777)2.48998855
38Microretrognathia (HP:0000308)2.46692415
39Missing ribs (HP:0000921)2.46152955
40Insidious onset (HP:0003587)2.45849660
41Termporal pattern (HP:0011008)2.45849660
42Neoplasm of striated muscle (HP:0009728)2.45392003
43Right ventricular cardiomyopathy (HP:0011663)2.44312970
44Overriding aorta (HP:0002623)2.43584290
45Impulsivity (HP:0100710)2.42611875
46Pili torti (HP:0003777)2.41805480
47Absent radius (HP:0003974)2.41700885
48Biliary tract neoplasm (HP:0100574)2.40940312
49Abnormal gallbladder physiology (HP:0012438)2.30767739
50Cholecystitis (HP:0001082)2.30767739
51Aplasia/hypoplasia of the humerus (HP:0006507)2.30324430
52Premature ovarian failure (HP:0008209)2.29095703
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.28640071
5411 pairs of ribs (HP:0000878)2.27971216
55Abnormality of pyrimidine metabolism (HP:0004353)2.26605578
56Supernumerary spleens (HP:0009799)2.25584997
57Back pain (HP:0003418)2.25479160
58Abdominal situs inversus (HP:0003363)2.25020558
59Abnormality of abdominal situs (HP:0011620)2.25020558
60Absent forearm bone (HP:0003953)2.23780288
61Aplasia involving forearm bones (HP:0009822)2.23780288
62Neoplasm of the oral cavity (HP:0100649)2.22905400
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.21423138
64Achilles tendon contracture (HP:0001771)2.17044666
65Aplastic anemia (HP:0001915)2.16998038
66Germ cell neoplasia (HP:0100728)2.16894847
67Basal cell carcinoma (HP:0002671)2.16545151
68Agnosia (HP:0010524)2.16486546
69Elfin facies (HP:0004428)2.14657438
70Abnormality of nail color (HP:0100643)2.14597733
71Increased nuchal translucency (HP:0010880)2.14050413
72Ovarian neoplasm (HP:0100615)2.13886638
73Proximal placement of thumb (HP:0009623)2.13631735
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10856559
75Resting tremor (HP:0002322)2.10260223
76Broad distal phalanx of finger (HP:0009836)2.10195721
77Abnormality of the lower motor neuron (HP:0002366)2.07831424
78Abnormality of the labia minora (HP:0012880)2.07793795
79Atresia of the external auditory canal (HP:0000413)2.06788129
80Abnormal number of incisors (HP:0011064)2.06689858
81Abnormality of the distal phalanges of the toes (HP:0010182)2.06580600
82Horseshoe kidney (HP:0000085)2.06502866
83Pallor (HP:0000980)2.05443900
84Ulnar bowing (HP:0003031)2.04949960
85Secondary amenorrhea (HP:0000869)2.04639815
86Meckel diverticulum (HP:0002245)2.02443009
87Neoplasm of the colon (HP:0100273)2.02182343
88Ankyloglossia (HP:0010296)2.00594174
89Abnormality of the umbilical cord (HP:0010881)2.00162200
90Megaloblastic anemia (HP:0001889)1.98870199
91Spastic diplegia (HP:0001264)1.98089260
92Neoplasm of the rectum (HP:0100743)1.97876153
93Abnormality of the ileum (HP:0001549)1.96398844
94Deviation of the thumb (HP:0009603)1.95805177
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.94578639
96Intestinal polyp (HP:0005266)1.94540338
97Premature graying of hair (HP:0002216)1.93682066
98Rhabdomyolysis (HP:0003201)1.92932521
99Patellar dislocation (HP:0002999)1.92839068
100Renal duplication (HP:0000075)1.92681930
101Flat acetabular roof (HP:0003180)1.91314981
102Pseudobulbar signs (HP:0002200)1.89831797
103Reticulocytosis (HP:0001923)1.89797895
104Abnormality of the preputium (HP:0100587)1.89718338
105Abnormality of reticulocytes (HP:0004312)1.89216769
106Short humerus (HP:0005792)1.88451689
107Intestinal polyposis (HP:0200008)1.88229170
108Abnormality of the salivary glands (HP:0010286)1.87291160
109Distal lower limb amyotrophy (HP:0008944)1.86622730
110Long palpebral fissure (HP:0000637)1.85702630
111Tracheoesophageal fistula (HP:0002575)1.84259448
112Hyperparathyroidism (HP:0000843)1.83445766
113Abnormality of the Achilles tendon (HP:0005109)1.83413508
114Testicular atrophy (HP:0000029)1.83284386
115Cellular immunodeficiency (HP:0005374)1.82021903
116Deep philtrum (HP:0002002)1.81593243
117Myopathic facies (HP:0002058)1.80960818
118High anterior hairline (HP:0009890)1.80344058
119Shawl scrotum (HP:0000049)1.79913779
120Abnormality of cochlea (HP:0000375)1.79899894
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79120708
122Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79120708
123Abnormality of glycolysis (HP:0004366)1.79033472
124Increased serum pyruvate (HP:0003542)1.79033472
125Overlapping toe (HP:0001845)1.78469246
126Gout (HP:0001997)1.77982085
127Facial cleft (HP:0002006)1.76998409
128Chromsome breakage (HP:0040012)1.76054841
129Ragged-red muscle fibers (HP:0003200)1.74653696
130Distal lower limb muscle weakness (HP:0009053)1.74648109
131Spinal cord compression (HP:0002176)1.74565272
132Advanced eruption of teeth (HP:0006288)1.73967893
133Unilateral renal agenesis (HP:0000122)1.73708471
134Abnormality of chromosome stability (HP:0003220)1.72936363
135CNS hypomyelination (HP:0003429)1.72343718
136Hyperacusis (HP:0010780)1.72238459
137Posterior subcapsular cataract (HP:0007787)1.72166857
138Cafe-au-lait spot (HP:0000957)1.71871053
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71326650
140Hypoparathyroidism (HP:0000829)1.70250762
141Hyperglycinuria (HP:0003108)1.69981499
142Sloping forehead (HP:0000340)1.69752456
143Abnormal lung lobation (HP:0002101)1.69032396
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.68918532
145Glossoptosis (HP:0000162)1.68735585
146Preauricular skin tag (HP:0000384)1.68392951
147Diaphragmatic weakness (HP:0009113)1.63657921
148Duplication of thumb phalanx (HP:0009942)1.62926239
149Abnormality of the gastric mucosa (HP:0004295)1.62027846
150Pointed chin (HP:0000307)1.61527093
151Microglossia (HP:0000171)1.60720877
152Progressive hearing impairment (HP:0001730)1.58398366
153Abnormal umbilical cord blood vessels (HP:0011403)1.58356213
154Single umbilical artery (HP:0001195)1.58356213
155Abnormality of the fetal cardiovascular system (HP:0010948)1.58356213
156Self-mutilation (HP:0000742)1.57871835
157Abnormality of the phalanges of the hallux (HP:0010057)1.57762877
158Abnormality of oral frenula (HP:0000190)1.56958133
159Sensory axonal neuropathy (HP:0003390)1.54749354
160Abnormal hair laboratory examination (HP:0003328)1.53843511
161Hypokinesia (HP:0002375)1.53741735
162Pterygium (HP:0001059)1.53733418
163Lower limb amyotrophy (HP:0007210)1.53139746
164Broad face (HP:0000283)1.52212193
165Generalized hypotonia (HP:0001290)1.51911425
166Fasciculations (HP:0002380)1.50480033
167Deep palmar crease (HP:0006191)1.50096636
168Dysphonia (HP:0001618)1.49659942
169Partial duplication of thumb phalanx (HP:0009944)1.48125483
170Turricephaly (HP:0000262)1.47754359
171Abnormalities of placenta or umbilical cord (HP:0001194)1.47246144
172Distal upper limb amyotrophy (HP:0007149)1.46558816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.42807815
2WEE14.12284252
3SMG13.66774919
4CDC73.56736787
5NEK12.91478772
6NEK22.62423188
7EPHA22.57693228
8TSSK62.55127277
9EIF2AK12.31607664
10TTK2.29475932
11PASK2.28752389
12RPS6KB22.23675138
13EEF2K2.13487532
14TESK22.08989208
15PBK1.95130223
16TLK11.91501153
17SCYL21.90088602
18IRAK31.85329010
19PKN21.85199668
20CDK121.80040132
21BCKDK1.75831167
22SRPK11.74791084
23PDK41.71315388
24PDK31.71315388
25VRK21.69567641
26PLK11.69224770
27CDK71.67814168
28PAK41.64400874
29ACVR1B1.64329282
30MAP3K101.61611508
31SIK11.58327177
32MAP3K91.54558117
33DYRK31.53610830
34TESK11.49387075
35BRSK21.46115305
36FLT31.44822248
37AURKB1.44618489
38ATR1.42685929
39MAP3K81.42449907
40AURKA1.37151223
41ARAF1.34495915
42MST1R1.34236548
43PLK41.30633326
44STK161.28841998
45MAPKAPK31.28074817
46TRIB31.26479370
47TGFBR11.24316213
48PRKD31.23039975
49CDK41.20081508
50NME21.14886476
51PRPF4B1.14177815
52CHEK21.13642933
53EIF2AK31.11842718
54CHEK11.10429020
55VRK11.05882074
56RIPK11.03863973
57BRSK11.01401253
58PNCK1.01296048
59ICK0.96337868
60PLK30.95394998
61KSR20.94602538
62STK100.94452423
63KDR0.92424087
64RPS6KA40.89591609
65MAP3K110.89197093
66LRRK20.88084262
67LATS20.87930611
68FGFR40.87456029
69MKNK10.86979544
70MTOR0.84011445
71CDK20.80894687
72PDK20.80686253
73STK38L0.76196453
74CAMK1D0.73869696
75TAF10.73867867
76ALK0.73614038
77PRKCI0.73220718
78ATM0.72578708
79STK40.72467740
80PAK10.68457313
81CSNK2A20.68040800
82MAP2K20.67097378
83NME10.63519226
84AKT20.62869271
85TTN0.61591838
86NTRK10.61579619
87BRD40.59375613
88MAPKAPK50.59146250
89RPS6KB10.58937864
90PTK20.58371487
91CSNK1E0.58207622
92LMTK20.58078710
93CDK80.55441238
94CDK140.55140106
95CDK150.54344185
96DAPK10.54232169
97CDK11A0.53616561
98CDK10.53068868
99NEK60.52902753
100CAMK1G0.52845039
101MAP3K130.52224368
102CDK180.51386113
103IRAK20.51281312
104ILK0.50493814
105* CSNK2A10.49569125
106FGFR10.46382265
107LATS10.45163836
108RAF10.42877159
109PIM20.42738639
110MET0.42683769
111ZAK0.41830135
112MAP2K30.41676942
113MAP3K10.41315886
114CDK60.41096375
115PAK20.40762728
116LIMK10.38929717
117PTK60.38096493
118DYRK1B0.34825615
119PDGFRA0.34714937
120RET0.34461346
121PRKDC0.34415289
122CDK90.33543393
123RPS6KA20.33383552
124AKT30.31888713
125PDPK10.31200342
126CCNB10.31040960
127PIM10.30568898
128BRAF0.29972409
129MKNK20.29925783
130ERN10.28711960
131TAOK20.28141169
132RPS6KA10.27837222
133DYRK20.25731491
134MAP3K30.24471692
135GRK60.23842955
136STK30.23012342
137MELK0.20168211

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53718486
2Mismatch repair_Homo sapiens_hsa034303.87330087
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19661934
4Spliceosome_Homo sapiens_hsa030403.16793458
5RNA transport_Homo sapiens_hsa030133.02408295
6One carbon pool by folate_Homo sapiens_hsa006703.02364471
7Ribosome_Homo sapiens_hsa030103.02110814
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95198591
9Proteasome_Homo sapiens_hsa030502.78011904
10Base excision repair_Homo sapiens_hsa034102.67087749
11RNA polymerase_Homo sapiens_hsa030202.52096476
12Nucleotide excision repair_Homo sapiens_hsa034202.42615046
13Cell cycle_Homo sapiens_hsa041102.26633597
14Homologous recombination_Homo sapiens_hsa034402.24472711
15Pyrimidine metabolism_Homo sapiens_hsa002402.19466466
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99369957
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92194013
18Biosynthesis of amino acids_Homo sapiens_hsa012301.90017306
19Selenocompound metabolism_Homo sapiens_hsa004501.74347542
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.62260026
21mRNA surveillance pathway_Homo sapiens_hsa030151.62046311
22Carbon metabolism_Homo sapiens_hsa012001.59964925
23Fanconi anemia pathway_Homo sapiens_hsa034601.52969590
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.49060692
25RNA degradation_Homo sapiens_hsa030181.44673099
26Folate biosynthesis_Homo sapiens_hsa007901.37251715
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36367423
28Pentose phosphate pathway_Homo sapiens_hsa000301.35066557
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32630188
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32593200
31Non-homologous end-joining_Homo sapiens_hsa034501.31969054
32Basal transcription factors_Homo sapiens_hsa030221.25796907
33Chronic myeloid leukemia_Homo sapiens_hsa052201.23881371
34Endometrial cancer_Homo sapiens_hsa052131.21012646
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15004300
36Sulfur relay system_Homo sapiens_hsa041221.14653865
37p53 signaling pathway_Homo sapiens_hsa041151.10795070
38Non-small cell lung cancer_Homo sapiens_hsa052231.08829309
39Systemic lupus erythematosus_Homo sapiens_hsa053221.08232872
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06969998
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.06464821
42Purine metabolism_Homo sapiens_hsa002301.06279821
43Pyruvate metabolism_Homo sapiens_hsa006201.05306235
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99712528
45Fructose and mannose metabolism_Homo sapiens_hsa000510.97723006
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97489167
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94784890
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92652358
49Prion diseases_Homo sapiens_hsa050200.91265400
50Oocyte meiosis_Homo sapiens_hsa041140.90361050
51Glioma_Homo sapiens_hsa052140.87513079
52ErbB signaling pathway_Homo sapiens_hsa040120.86002394
53Insulin signaling pathway_Homo sapiens_hsa049100.84262622
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84201973
55Epstein-Barr virus infection_Homo sapiens_hsa051690.82805999
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81936015
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80577048
58Prostate cancer_Homo sapiens_hsa052150.80512969
59Vibrio cholerae infection_Homo sapiens_hsa051100.79027140
60Glutathione metabolism_Homo sapiens_hsa004800.77846757
61Viral carcinogenesis_Homo sapiens_hsa052030.76955845
62Pancreatic cancer_Homo sapiens_hsa052120.76306808
63Acute myeloid leukemia_Homo sapiens_hsa052210.75713133
64Thyroid cancer_Homo sapiens_hsa052160.74778575
65VEGF signaling pathway_Homo sapiens_hsa043700.74254337
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.72215256
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70275922
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69058844
69Propanoate metabolism_Homo sapiens_hsa006400.68202382
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66837959
71Galactose metabolism_Homo sapiens_hsa000520.66128162
72Basal cell carcinoma_Homo sapiens_hsa052170.66027088
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63465973
74Arginine and proline metabolism_Homo sapiens_hsa003300.60806423
75Fatty acid degradation_Homo sapiens_hsa000710.60212438
76Hippo signaling pathway_Homo sapiens_hsa043900.60035540
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59770291
78Huntingtons disease_Homo sapiens_hsa050160.58558846
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58080328
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.57433414
81Antigen processing and presentation_Homo sapiens_hsa046120.55492587
82Vitamin B6 metabolism_Homo sapiens_hsa007500.54525449
83Fat digestion and absorption_Homo sapiens_hsa049750.54135721
84Renal cell carcinoma_Homo sapiens_hsa052110.53904682
85Lysine degradation_Homo sapiens_hsa003100.52644525
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51228581
87* Estrogen signaling pathway_Homo sapiens_hsa049150.50931440
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49646037
89N-Glycan biosynthesis_Homo sapiens_hsa005100.48656720
90Fatty acid biosynthesis_Homo sapiens_hsa000610.48238326
91Melanoma_Homo sapiens_hsa052180.46935831
92HTLV-I infection_Homo sapiens_hsa051660.46824970
93Notch signaling pathway_Homo sapiens_hsa043300.46072803
94Parkinsons disease_Homo sapiens_hsa050120.45656783
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45577660
96Synaptic vesicle cycle_Homo sapiens_hsa047210.45383040
97Bladder cancer_Homo sapiens_hsa052190.45365828
98Apoptosis_Homo sapiens_hsa042100.45353464
99Gap junction_Homo sapiens_hsa045400.44045056
100Hedgehog signaling pathway_Homo sapiens_hsa043400.43314425
101Wnt signaling pathway_Homo sapiens_hsa043100.41542426
102Proteoglycans in cancer_Homo sapiens_hsa052050.41443796
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41352414
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41264741
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.40405506
106Metabolic pathways_Homo sapiens_hsa011000.39745668
107Inositol phosphate metabolism_Homo sapiens_hsa005620.37631280
108Alcoholism_Homo sapiens_hsa050340.35826758
109Tight junction_Homo sapiens_hsa045300.34978826
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32400422
111Small cell lung cancer_Homo sapiens_hsa052220.30736614
112MicroRNAs in cancer_Homo sapiens_hsa052060.30462628
113Herpes simplex infection_Homo sapiens_hsa051680.29899681
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28956224
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27946113
116mTOR signaling pathway_Homo sapiens_hsa041500.27273470
117Arginine biosynthesis_Homo sapiens_hsa002200.27039144
118Legionellosis_Homo sapiens_hsa051340.26688638
119Tryptophan metabolism_Homo sapiens_hsa003800.25722432
120Protein export_Homo sapiens_hsa030600.24272597
121Fatty acid metabolism_Homo sapiens_hsa012120.22890018
122Phenylalanine metabolism_Homo sapiens_hsa003600.20560759
123beta-Alanine metabolism_Homo sapiens_hsa004100.19314595
124Renin-angiotensin system_Homo sapiens_hsa046140.19310184
125AMPK signaling pathway_Homo sapiens_hsa041520.18922973
126HIF-1 signaling pathway_Homo sapiens_hsa040660.18857428
127Colorectal cancer_Homo sapiens_hsa052100.17278581
128Tyrosine metabolism_Homo sapiens_hsa003500.17051095
129TGF-beta signaling pathway_Homo sapiens_hsa043500.16831182
130Glucagon signaling pathway_Homo sapiens_hsa049220.16749907
131Adherens junction_Homo sapiens_hsa045200.14707227
132Oxidative phosphorylation_Homo sapiens_hsa001900.12924746

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