FKBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.16728571
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.71331453
3signal peptide processing (GO:0006465)5.69095398
4ATP synthesis coupled proton transport (GO:0015986)5.47684751
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.47684751
6respiratory electron transport chain (GO:0022904)5.34122428
7electron transport chain (GO:0022900)5.26030007
8ribosomal small subunit biogenesis (GO:0042274)4.35603463
9protein maturation by protein folding (GO:0022417)4.18146677
10chaperone-mediated protein transport (GO:0072321)4.03171426
11protein complex biogenesis (GO:0070271)3.84309041
12GDP-mannose metabolic process (GO:0019673)3.83494096
13regulation of oxidative phosphorylation (GO:0002082)3.77019938
14protein targeting to ER (GO:0045047)3.71630472
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69957921
16cotranslational protein targeting to membrane (GO:0006613)3.68479144
17protein localization to endoplasmic reticulum (GO:0070972)3.63532095
18water-soluble vitamin biosynthetic process (GO:0042364)3.61050284
19hydrogen ion transmembrane transport (GO:1902600)3.60784581
20inner mitochondrial membrane organization (GO:0007007)3.54756429
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52990486
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.51184239
23ATP hydrolysis coupled proton transport (GO:0015991)3.51184239
24viral transcription (GO:0019083)3.49007058
25L-phenylalanine catabolic process (GO:0006559)3.47647766
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.47647766
27proteasome assembly (GO:0043248)3.47336311
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.43893180
29NADH dehydrogenase complex assembly (GO:0010257)3.43893180
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43893180
31mitochondrial respiratory chain complex assembly (GO:0033108)3.41588747
32regulation of cellular amino acid metabolic process (GO:0006521)3.38433099
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34172717
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34172717
35termination of RNA polymerase III transcription (GO:0006386)3.31519900
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.31519900
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.29319686
38L-phenylalanine metabolic process (GO:0006558)3.29319686
39translational termination (GO:0006415)3.28075708
40proton transport (GO:0015992)3.27871497
41negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.25969699
42hydrogen transport (GO:0006818)3.21160210
43aldehyde catabolic process (GO:0046185)3.18747080
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14544504
45dopamine transport (GO:0015872)3.11171802
46ER overload response (GO:0006983)3.10624980
47platelet dense granule organization (GO:0060155)3.09258242
48positive regulation of prostaglandin secretion (GO:0032308)3.08981371
49nucleotide transmembrane transport (GO:1901679)3.08413458
50protein neddylation (GO:0045116)3.07540848
51translation (GO:0006412)3.06188819
52ATP biosynthetic process (GO:0006754)3.05686300
53positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.04638356
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02918618
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02842884
56purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00706832
573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00706832
58protein localization to mitochondrion (GO:0070585)2.99598207
59pseudouridine synthesis (GO:0001522)2.97037710
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.95640783
61ribosomal small subunit assembly (GO:0000028)2.95562132
62mitochondrial transport (GO:0006839)2.94826146
63GTP biosynthetic process (GO:0006183)2.92890929
64cellular response to zinc ion (GO:0071294)2.92018494
65respiratory chain complex IV assembly (GO:0008535)2.90159261
66rRNA modification (GO:0000154)2.88096747
67glutathione derivative biosynthetic process (GO:1901687)2.87939528
68glutathione derivative metabolic process (GO:1901685)2.87939528
69cellular component biogenesis (GO:0044085)2.87854905
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85290119
71regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.85229918
72regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.84261572
73regulation of mitochondrial translation (GO:0070129)2.83952823
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83749676
75translational elongation (GO:0006414)2.82942479
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81095015
77C-terminal protein lipidation (GO:0006501)2.80142980
78transferrin transport (GO:0033572)2.79156186
79COPI coating of Golgi vesicle (GO:0048205)2.77414160
80Golgi transport vesicle coating (GO:0048200)2.77414160
81fatty acid elongation (GO:0030497)2.76500301
82viral life cycle (GO:0019058)2.75806772
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74350417
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72249795
85cytochrome complex assembly (GO:0017004)2.70947891
86pyrimidine-containing compound transmembrane transport (GO:0072531)2.70873747
87peptide hormone processing (GO:0016486)2.68061823
88regulation of cellular amine metabolic process (GO:0033238)2.67817256
89phenol-containing compound catabolic process (GO:0019336)2.66572523
90DNA deamination (GO:0045006)2.66568412
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65939548
92dopamine biosynthetic process (GO:0042416)2.65906832
93regulation of catecholamine metabolic process (GO:0042069)2.65320830
94regulation of dopamine metabolic process (GO:0042053)2.65320830
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63740044
96positive regulation of TOR signaling (GO:0032008)2.63262194
97protein retention in ER lumen (GO:0006621)2.62275824
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60244453
99negative regulation of ligase activity (GO:0051352)2.59886502
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59886502
101response to misfolded protein (GO:0051788)2.59791859
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59263907
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59263907
104ferric iron transport (GO:0015682)2.59112132
105trivalent inorganic cation transport (GO:0072512)2.59112132
106mannosylation (GO:0097502)2.58462961
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57971102
108phagosome maturation (GO:0090382)2.57427040
109response to interferon-beta (GO:0035456)2.57089477
110cellular response to oxygen radical (GO:0071450)2.56972512
111removal of superoxide radicals (GO:0019430)2.56972512
112cellular response to superoxide (GO:0071451)2.56972512
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56957880
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56957880
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56957880
116neuronal action potential propagation (GO:0019227)2.55955620
117xenobiotic catabolic process (GO:0042178)2.55850766
118guanosine-containing compound biosynthetic process (GO:1901070)2.55818521
119nucleoside diphosphate catabolic process (GO:0009134)2.54378589
120positive regulation of respiratory burst (GO:0060267)2.52333683
121ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.48978454
122positive regulation of cellular amine metabolic process (GO:0033240)2.47094307
123alkaloid metabolic process (GO:0009820)2.45939503
124catecholamine transport (GO:0051937)2.45560364
125cofactor catabolic process (GO:0051187)2.41694743
126glutathione biosynthetic process (GO:0006750)2.41069500
127calcium-mediated signaling using intracellular calcium source (GO:0035584)2.39073855
128endocrine pancreas development (GO:0031018)2.37545924
129response to methylmercury (GO:0051597)2.36256854
130negative regulation of catecholamine secretion (GO:0033604)2.35822975
131coenzyme catabolic process (GO:0009109)2.35261363
132oxidative phosphorylation (GO:0006119)2.32513421
133protein targeting to mitochondrion (GO:0006626)2.32507857
134catechol-containing compound biosynthetic process (GO:0009713)2.31802551
135catecholamine biosynthetic process (GO:0042423)2.31802551
136intracellular protein transmembrane import (GO:0044743)2.31225978
137aromatic amino acid family catabolic process (GO:0009074)2.29476387
138sequestering of metal ion (GO:0051238)2.29057326
139nucleoside triphosphate biosynthetic process (GO:0009142)2.27998686
140cellular response to leptin stimulus (GO:0044320)2.27911880
141dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.27901870
142deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.26328994
143establishment of protein localization to mitochondrion (GO:0072655)2.26017794
144peptide metabolic process (GO:0006518)2.25990330
145substantia nigra development (GO:0021762)2.25821890
146detection of calcium ion (GO:0005513)2.25521835
147negative regulation of norepinephrine secretion (GO:0010700)2.24142212
148cellular copper ion homeostasis (GO:0006878)2.23989510
149UTP biosynthetic process (GO:0006228)2.23949188
150nonribosomal peptide biosynthetic process (GO:0019184)2.23817057
151monoamine transport (GO:0015844)2.23455275
152regulation of autophagic vacuole assembly (GO:2000785)2.23143050
153amyloid precursor protein metabolic process (GO:0042982)2.22922987
154toxin metabolic process (GO:0009404)2.22826954
155protein localization to cilium (GO:0061512)2.22586792
156presynaptic membrane assembly (GO:0097105)2.19100239
157peroxisome fission (GO:0016559)2.18273755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.11450823
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.97822825
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80621020
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16608956
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.14727873
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85568806
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.84064737
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63716244
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62797780
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46271660
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33168749
12EZH2_22144423_ChIP-Seq_EOC_Human2.29648258
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26084916
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22238475
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.14695288
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14396736
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06834649
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.93773121
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91385550
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.86319834
21* GABP_19822575_ChIP-Seq_HepG2_Human1.85020225
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.81859903
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80560095
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76978015
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71149085
26GBX2_23144817_ChIP-Seq_PC3_Human1.70267793
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.69801354
28* RXR_22158963_ChIP-Seq_LIVER_Mouse1.67089694
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66731465
30XRN2_22483619_ChIP-Seq_HELA_Human1.63213500
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60346293
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58568703
33* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57678929
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55272296
35TAF15_26573619_Chip-Seq_HEK293_Human1.54571294
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53791946
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53691209
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53180021
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51935644
40REST_21632747_ChIP-Seq_MESCs_Mouse1.51843398
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51032365
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49767568
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46413871
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45965063
45ZNF263_19887448_ChIP-Seq_K562_Human1.41657418
46FOXP3_21729870_ChIP-Seq_TREG_Human1.41395127
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40975486
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40803680
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40387130
50VDR_22108803_ChIP-Seq_LS180_Human1.40270695
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.38716827
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35998658
53HTT_18923047_ChIP-ChIP_STHdh_Human1.34662990
54BCL6_27268052_Chip-Seq_Bcells_Human1.34342066
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.34042721
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33701332
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33505582
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33055306
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32659937
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.30912484
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.28742121
62* TTF2_22483619_ChIP-Seq_HELA_Human1.27647798
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26579172
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23799395
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.23096348
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22513240
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21647073
68BCOR_27268052_Chip-Seq_Bcells_Human1.20484874
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19821100
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18594746
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17951650
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17358984
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16712748
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15443524
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13174521
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12503603
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12427250
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12387330
79LXR_22292898_ChIP-Seq_THP-1_Human1.11517814
80* CTCF_26484167_Chip-Seq_Bcells_Mouse1.10994469
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10689100
82P68_20966046_ChIP-Seq_HELA_Human1.10640219
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09899396
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.08480764
85E2F1_20622854_ChIP-Seq_HELA_Human1.08453556
86SA1_27219007_Chip-Seq_Bcells_Human1.07666032
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07578688
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07199756
89* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07005670
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06618084
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06162095
92ERA_21632823_ChIP-Seq_H3396_Human1.05480737
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05390240
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.05151946
95TAF2_19829295_ChIP-Seq_ESCs_Human1.05088099
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03443755
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02774523
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.02705915
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02417254
100P300_27268052_Chip-Seq_Bcells_Human1.02177996
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01872763
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01675252
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01625146
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01170285
105ELK1_19687146_ChIP-ChIP_HELA_Human1.01169744
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00744554
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98611566
108ERG_20517297_ChIP-Seq_VCAP_Human0.98341020
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97926446
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97854084
111* STAT1_20625510_ChIP-Seq_HELA_Human0.97584047
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96895731
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96587312
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96443675
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96380530
116MYC_19829295_ChIP-Seq_ESCs_Human0.96197374
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.95945117
118REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95909191
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95627911
120NCOR_22424771_ChIP-Seq_293T_Human0.94710623
121* KDM5A_27292631_Chip-Seq_BREAST_Human0.94550624
122EED_16625203_ChIP-ChIP_MESCs_Mouse0.94273329
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94153112
124PHF8_20622854_ChIP-Seq_HELA_Human0.94092447
125IGF1R_20145208_ChIP-Seq_DFB_Human0.94005242
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93976482
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.92614704
128AR_20517297_ChIP-Seq_VCAP_Human0.92320349
129* RARB_24833708_ChIP-Seq_LIVER_Mouse0.91411350
130* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90992467
131* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90380820
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89681654
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88955326
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88805851
135NANOG_20526341_ChIP-Seq_ESCs_Human0.87949072
136SOX2_19829295_ChIP-Seq_ESCs_Human0.87616314
137NANOG_19829295_ChIP-Seq_ESCs_Human0.87616314
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86986699
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86650036
140MYC_18940864_ChIP-ChIP_HL60_Human0.86621633
141BP1_19119308_ChIP-ChIP_Hs578T_Human0.86465354
142P300_19829295_ChIP-Seq_ESCs_Human0.84903592
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84847393
144DCP1A_22483619_ChIP-Seq_HELA_Human0.84022667
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.83280006
146* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83114423
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82226674
148VDR_23849224_ChIP-Seq_CD4+_Human0.82156408
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81986173
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78759828
151CTCF_20526341_ChIP-Seq_ESCs_Human0.78313460
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77484688
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77161106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.26885922
2MP0002139_abnormal_hepatobiliary_system2.92864779
3MP0003880_abnormal_central_pattern2.83918681
4MP0003195_calcinosis2.76846630
5MP0002822_catalepsy2.66087344
6MP0001529_abnormal_vocalization2.65337632
7MP0004043_abnormal_pH_regulation2.53452031
8MP0004147_increased_porphyrin_level2.41144578
9MP0006276_abnormal_autonomic_nervous2.33034759
10MP0001905_abnormal_dopamine_level2.29279338
11MP0008875_abnormal_xenobiotic_pharmacok2.23408178
12MP0005379_endocrine/exocrine_gland_phen2.17804268
13MP0003123_paternal_imprinting2.16698727
14MP0005085_abnormal_gallbladder_physiolo2.14751750
15MP0002876_abnormal_thyroid_physiology2.10973495
16MP0003011_delayed_dark_adaptation2.06575373
17MP0004019_abnormal_vitamin_homeostasis2.04639336
18MP0005365_abnormal_bile_salt2.04028535
19MP0004270_analgesia1.97777083
20MP0009840_abnormal_foam_cell1.94014969
21MP0002272_abnormal_nervous_system1.91712329
22MP0005646_abnormal_pituitary_gland1.89057889
23MP0001970_abnormal_pain_threshold1.88545855
24MP0002734_abnormal_mechanical_nocicepti1.88202188
25MP0002733_abnormal_thermal_nociception1.84497122
26MP0001968_abnormal_touch/_nociception1.84465310
27MP0002064_seizures1.84365960
28MP0000013_abnormal_adipose_tissue1.84260608
29MP0009745_abnormal_behavioral_response1.82533664
30MP0005083_abnormal_biliary_tract1.81392585
31MP0002736_abnormal_nociception_after1.81171937
32MP0002837_dystrophic_cardiac_calcinosis1.80384777
33MP0002693_abnormal_pancreas_physiology1.79328647
34MP0001986_abnormal_taste_sensitivity1.79247870
35MP0001440_abnormal_grooming_behavior1.75976973
36MP0005645_abnormal_hypothalamus_physiol1.73520246
37MP0002735_abnormal_chemical_nociception1.73364821
38MP0006036_abnormal_mitochondrial_physio1.70679904
39MP0004142_abnormal_muscle_tone1.70025667
40MP0001984_abnormal_olfaction1.67981348
41MP0003635_abnormal_synaptic_transmissio1.64747935
42MP0003183_abnormal_peptide_metabolism1.63356656
43MP0001501_abnormal_sleep_pattern1.63286008
44MP0002909_abnormal_adrenal_gland1.62782546
45MP0005360_urolithiasis1.60057425
46MP0005636_abnormal_mineral_homeostasis1.59770044
47MP0009379_abnormal_foot_pigmentation1.56429450
48MP0002572_abnormal_emotion/affect_behav1.54164563
49MP0002638_abnormal_pupillary_reflex1.53462430
50MP0001666_abnormal_nutrient_absorption1.51680728
51MP0002938_white_spotting1.50187417
52MP0009046_muscle_twitch1.50154406
53MP0005332_abnormal_amino_acid1.50139583
54MP0005535_abnormal_body_temperature1.46110981
55MP0002148_abnormal_hypersensitivity_rea1.45958591
56MP0003806_abnormal_nucleotide_metabolis1.45937705
57MP0005058_abnormal_lysosome_morphology1.45565987
58MP0003329_amyloid_beta_deposits1.43906627
59MP0001944_abnormal_pancreas_morphology1.43264068
60MP0003186_abnormal_redox_activity1.41173731
61MP0001764_abnormal_homeostasis1.37350483
62MP0003075_altered_response_to1.35963016
63MP0001664_abnormal_digestion1.35645938
64MP0002277_abnormal_respiratory_mucosa1.35420873
65MP0005084_abnormal_gallbladder_morpholo1.34893937
66MP0009780_abnormal_chondrocyte_physiolo1.34485344
67MP0000343_altered_response_to1.33498559
68MP0002163_abnormal_gland_morphology1.26276907
69MP0003879_abnormal_hair_cell1.25575483
70MP0002254_reproductive_system_inflammat1.24917622
71MP0001765_abnormal_ion_homeostasis1.24350405
72MP0002063_abnormal_learning/memory/cond1.24273257
73MP0004859_abnormal_synaptic_plasticity1.23649075
74MP0003868_abnormal_feces_composition1.21350820
75MP0005220_abnormal_exocrine_pancreas1.18907690
76MP0002067_abnormal_sensory_capabilities1.18771243
77MP0000920_abnormal_myelination1.18751456
78MP0003787_abnormal_imprinting1.17770516
79MP0008872_abnormal_physiological_respon1.15728308
80MP0003786_premature_aging1.15306066
81MP0002078_abnormal_glucose_homeostasis1.14121204
82MP0009643_abnormal_urine_homeostasis1.12414988
83MP0000372_irregular_coat_pigmentation1.11191026
84MP0000538_abnormal_urinary_bladder1.11025318
85MP0004510_myositis1.09949663
86MP0002229_neurodegeneration1.09223196
87MP0001486_abnormal_startle_reflex1.06371779
88MP0005410_abnormal_fertilization1.06203094
89MP0005551_abnormal_eye_electrophysiolog1.05063856
90MP0002653_abnormal_ependyma_morphology1.04354921
91MP0009764_decreased_sensitivity_to1.04336452
92MP0004924_abnormal_behavior1.03679652
93MP0005386_behavior/neurological_phenoty1.03679652
94MP0001542_abnormal_bone_strength1.02725360
95MP0002118_abnormal_lipid_homeostasis1.00147248
96MP0005310_abnormal_salivary_gland0.99503269
97MP0002557_abnormal_social/conspecific_i0.98806081
98MP0009785_altered_susceptibility_to0.98377149
99MP0001502_abnormal_circadian_rhythm0.98112624
100MP0005584_abnormal_enzyme/coenzyme_acti0.97420765
101MP0005319_abnormal_enzyme/_coenzyme0.96912150
102MP0001756_abnormal_urination0.96493046
103MP0002090_abnormal_vision0.95407424
104MP0001853_heart_inflammation0.94876237
105MP0003122_maternal_imprinting0.93680804
106MP0006072_abnormal_retinal_apoptosis0.92856808
107MP0003953_abnormal_hormone_level0.92725353
108MP0008469_abnormal_protein_level0.92452249
109MP0006035_abnormal_mitochondrial_morpho0.92166757
110MP0001188_hyperpigmentation0.91407437
111MP0005165_increased_susceptibility_to0.90911018
112MP0004885_abnormal_endolymph0.90534528
113MP0000604_amyloidosis0.90293208
114MP0001485_abnormal_pinna_reflex0.85878475
115MP0010329_abnormal_lipoprotein_level0.85288238
116MP0000678_abnormal_parathyroid_gland0.85168416
117MP0002138_abnormal_hepatobiliary_system0.85114821
118MP0003718_maternal_effect0.84911293
119MP0003633_abnormal_nervous_system0.84595853
120MP0003866_abnormal_defecation0.84594784
121MP0005253_abnormal_eye_physiology0.82735951
122MP0003638_abnormal_response/metabolism_0.82386882
123MP0000639_abnormal_adrenal_gland0.81974425
124MP0000230_abnormal_systemic_arterial0.79917566
125MP0005448_abnormal_energy_balance0.79425293
126MP0000358_abnormal_cell_content/0.78935923
127MP0005166_decreased_susceptibility_to0.78746419
128MP0003172_abnormal_lysosome_physiology0.78336375
129MP0002295_abnormal_pulmonary_circulatio0.78333956
130MP0003634_abnormal_glial_cell0.78186170
131MP0002066_abnormal_motor_capabilities/c0.78029145
132MP0005408_hypopigmentation0.77832529
133MP0002069_abnormal_eating/drinking_beha0.77327448
134MP0006082_CNS_inflammation0.76511459
135MP0003656_abnormal_erythrocyte_physiolo0.76104987
136MP0000681_abnormal_thyroid_gland0.75581174
137MP0004742_abnormal_vestibular_system0.73327562

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.44353909
2Abnormal mitochondria in muscle tissue (HP:0008316)4.99920943
3Mitochondrial inheritance (HP:0001427)4.83304869
4Acute encephalopathy (HP:0006846)4.81902903
5Progressive macrocephaly (HP:0004481)4.48181060
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05781176
7Increased CSF lactate (HP:0002490)4.02545062
8Hepatocellular necrosis (HP:0001404)4.00868092
9Hepatic necrosis (HP:0002605)3.94208996
10Hypothermia (HP:0002045)3.68784037
11Renal Fanconi syndrome (HP:0001994)3.52962643
12Cerebral edema (HP:0002181)3.52238205
13Increased hepatocellular lipid droplets (HP:0006565)3.48297571
14Lipid accumulation in hepatocytes (HP:0006561)3.31313454
15Increased intramyocellular lipid droplets (HP:0012240)3.06034053
16Myokymia (HP:0002411)3.04144898
17Neuroendocrine neoplasm (HP:0100634)3.03414127
18Vacuolated lymphocytes (HP:0001922)3.03258316
19Pheochromocytoma (HP:0002666)2.99908028
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98456590
21Testicular atrophy (HP:0000029)2.96618063
22Leukodystrophy (HP:0002415)2.94620610
233-Methylglutaconic aciduria (HP:0003535)2.88532812
24Respiratory failure (HP:0002878)2.85538954
25Lactic acidosis (HP:0003128)2.85416993
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84698923
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84698923
28Abnormality of liposaccharide metabolism (HP:0010968)2.78829794
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.78829794
30Abnormality of glycolipid metabolism (HP:0010969)2.78829794
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75838000
32Increased muscle lipid content (HP:0009058)2.72708198
33Optic disc pallor (HP:0000543)2.71129161
34Abnormality of urine glucose concentration (HP:0011016)2.69443918
35Glycosuria (HP:0003076)2.69443918
36Prolonged neonatal jaundice (HP:0006579)2.69003420
37Hypoglycemic coma (HP:0001325)2.67194660
38Exercise intolerance (HP:0003546)2.63382054
39Abnormality of renal resorption (HP:0011038)2.62782793
40Prolonged partial thromboplastin time (HP:0003645)2.51015006
41Hyperphosphaturia (HP:0003109)2.47826190
42Hyperinsulinemic hypoglycemia (HP:0000825)2.47148144
43Retinal dysplasia (HP:0007973)2.45639658
44Generalized aminoaciduria (HP:0002909)2.41764742
45Type I transferrin isoform profile (HP:0003642)2.39548892
46Hypoglycemic seizures (HP:0002173)2.37940596
47Increased serum lactate (HP:0002151)2.37835855
48Cerebral hypomyelination (HP:0006808)2.36827812
49Lethargy (HP:0001254)2.33146778
50Conjugated hyperbilirubinemia (HP:0002908)2.30401682
51Focal motor seizures (HP:0011153)2.24936895
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24508399
53Dysostosis multiplex (HP:0000943)2.24121950
54Symptomatic seizures (HP:0011145)2.23008001
55Hyperthyroidism (HP:0000836)2.21786700
56Spastic paraparesis (HP:0002313)2.19985937
57Exertional dyspnea (HP:0002875)2.19182903
58Ketoacidosis (HP:0001993)2.18197493
59Abnormality of cells of the erythroid lineage (HP:0012130)2.17438406
60Molar tooth sign on MRI (HP:0002419)2.17213974
61Abnormality of midbrain morphology (HP:0002418)2.17213974
62Progressive neurologic deterioration (HP:0002344)2.16163608
63Abnormal protein glycosylation (HP:0012346)2.13690883
64Abnormal glycosylation (HP:0012345)2.13690883
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13690883
66Abnormal protein N-linked glycosylation (HP:0012347)2.13690883
67Macrocytic anemia (HP:0001972)2.12882530
68Systemic lupus erythematosus (HP:0002725)2.11894444
69Abnormal number of erythroid precursors (HP:0012131)2.08842165
70Limb dystonia (HP:0002451)2.08401452
71Microretrognathia (HP:0000308)2.06989763
72Anxiety (HP:0000739)2.06110520
73CNS demyelination (HP:0007305)2.04818420
74Blindness (HP:0000618)2.03699456
75Late onset (HP:0003584)2.00748723
76Emotional lability (HP:0000712)1.99786026
77Abnormal pupillary function (HP:0007686)1.99154296
78Delusions (HP:0000746)1.99068306
79Hypokinesia (HP:0002375)1.97757266
80Abnormal autonomic nervous system physiology (HP:0012332)1.97088090
81Atonic seizures (HP:0010819)1.96559698
82Medial flaring of the eyebrow (HP:0010747)1.95897934
83Visual hallucinations (HP:0002367)1.95825407
84Ketosis (HP:0001946)1.95587216
85Abnormality of the intrinsic pathway (HP:0010989)1.94270790
86Large for gestational age (HP:0001520)1.93527012
87Dysautonomia (HP:0002459)1.92910336
88Abnormal urine phosphate concentration (HP:0012599)1.92615599
89Agitation (HP:0000713)1.92522052
90Neurofibrillary tangles (HP:0002185)1.91138080
91Nuclear cataract (HP:0100018)1.90073933
92Vomiting (HP:0002013)1.89822062
93X-linked dominant inheritance (HP:0001423)1.89424510
94Increased serum pyruvate (HP:0003542)1.89051352
95Abnormality of glycolysis (HP:0004366)1.89051352
96Congenital primary aphakia (HP:0007707)1.88907497
97Methylmalonic aciduria (HP:0012120)1.88830438
98Gait imbalance (HP:0002141)1.88282507
99Reticulocytopenia (HP:0001896)1.88136006
100Dicarboxylic aciduria (HP:0003215)1.87835390
101Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87835390
102Brushfield spots (HP:0001088)1.86537872
103Poor suck (HP:0002033)1.85043856
104Abnormality of magnesium homeostasis (HP:0004921)1.82982501
105Hyperglycinemia (HP:0002154)1.82856442
106Gout (HP:0001997)1.82216301
107Congenital ichthyosiform erythroderma (HP:0007431)1.81365158
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80152792
109Delayed CNS myelination (HP:0002188)1.79703477
110Methylmalonic acidemia (HP:0002912)1.78243426
111Nephrogenic diabetes insipidus (HP:0009806)1.77481055
112Reduced antithrombin III activity (HP:0001976)1.76348229
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.75972939
114Polyphagia (HP:0002591)1.75622446
115Urinary glycosaminoglycan excretion (HP:0003541)1.74926428
116Mucopolysacchariduria (HP:0008155)1.74926428
117Renal tubular dysfunction (HP:0000124)1.74022191
118Abnormal gallbladder physiology (HP:0012438)1.73511324
119Cholecystitis (HP:0001082)1.73511324
120Alkalosis (HP:0001948)1.72481635
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70956886
122Focal dystonia (HP:0004373)1.70784832
123Hyperactive renin-angiotensin system (HP:0000841)1.68918323
124Respiratory difficulties (HP:0002880)1.68553321
125Opisthotonus (HP:0002179)1.67610310
126Nausea (HP:0002018)1.65104671
127Xanthomatosis (HP:0000991)1.62269712
128Aplasia/hypoplasia of the uterus (HP:0008684)1.61163985
129Abnormality of vitamin B metabolism (HP:0004340)1.58977632
130Abnormality of polysaccharide metabolism (HP:0011012)1.58892411
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58892411
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58892411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.43999053
2ARAF4.06177362
3NME13.29446968
4MAP3K123.03070923
5STK162.90606263
6GRK52.45825465
7BCKDK2.45200924
8CASK2.37717328
9MAPK152.29477063
10NME22.15877821
11WNK42.15779965
12BRAF2.01786121
13GRK71.96812950
14PIM21.96207281
15NTRK31.92003030
16NTRK11.88439634
17INSRR1.82278698
18STK391.81583755
19RIPK11.80941363
20ERN11.76265247
21MAP4K21.74937278
22OXSR11.73545119
23ADRBK21.73161165
24MAPKAPK51.72326019
25MST41.69995586
26TAOK31.52580686
27PDK21.47845454
28MAP2K71.47238881
29CAMKK21.46250017
30EIF2AK31.44135581
31MAPKAPK31.35915611
32BMPR21.35019508
33CAMK2B1.33740881
34EPHA21.32492877
35MYLK1.32403235
36IRAK31.29192659
37IRAK21.28954039
38RIPK41.25472836
39TLK11.22843759
40CDK191.20448349
41CAMK2G1.19584786
42CAMK2D1.19210126
43BUB11.17025123
44MAP3K21.16601700
45PHKG11.16138387
46PHKG21.16138387
47TNIK1.14816168
48ILK1.14088247
49MAP2K61.13187723
50WNK31.10582236
51LIMK11.09103624
52KDR1.09022036
53UHMK11.08576849
54VRK11.05798267
55MAP2K21.04657532
56PBK0.99419640
57NEK10.95697426
58ABL20.95391263
59AKT30.93183478
60MUSK0.93073341
61TAOK10.91711119
62TNK20.91383138
63BCR0.88160844
64PRKCE0.86860515
65LRRK20.86131494
66PIK3CG0.85241020
67DAPK10.83883950
68EPHA40.83706417
69IKBKB0.82022646
70ADRBK10.81727651
71PLK20.81492271
72PNCK0.80246385
73CAMK2A0.80191372
74MINK10.79182440
75DAPK20.78120704
76MAP3K40.77172024
77PINK10.76429053
78CSNK1G30.74101310
79MAP2K40.74001810
80PRKCG0.73813344
81TBK10.73455957
82FES0.73143269
83TESK10.69319250
84FRK0.67701655
85MAP3K110.67669780
86MAP3K10.67611266
87AURKA0.67490312
88NUAK10.67466459
89DYRK20.64935605
90HIPK20.64451072
91CSNK2A20.63750652
92MAP3K30.63650199
93PAK10.61936239
94PIK3CA0.60153441
95DAPK30.58916881
96FER0.58871339
97PRKG20.57973118
98PRKCI0.57115370
99CDK50.55870067
100MAPK130.55861773
101PAK30.55853422
102IRAK40.54246639
103PAK40.53882383
104CSNK1G20.53039059
105CSNK2A10.52951509
106PRKACA0.52752553
107BMPR1B0.52563769
108TESK20.51499077
109PASK0.49952495
110CSNK1A1L0.49888275
111EPHB20.49714442
112CCNB10.48966029
113RPS6KA50.48391691
114EIF2AK10.47591865
115TXK0.46999231
116GRK60.46378972
117TSSK60.46235061
118TEC0.46135721
119RAF10.45739320
120IRAK10.45731910
121PRKCD0.45419777
122CSNK1G10.43490035
123PRKCA0.43370062
124CAMK10.43335616
125PRKCQ0.41788651
126SIK30.41709961
127CSNK1A10.39623551
128SYK0.39114388
129CDK140.38061144
130LMTK20.37736515
131ZAK0.37219053
132PKN10.37116963
133IKBKE0.35642910
134MAP2K10.35405004
135KSR20.35267331
136TAOK20.34616160
137MOS0.33612796
138PDPK10.32689247
139SGK2230.32652004
140SGK4940.32652004
141MST1R0.32513720
142PRKCZ0.32034158
143GRK10.31166155
144ACVR1B0.30742373
145PTK20.28146585
146PLK10.27390080

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.82726418
2Protein export_Homo sapiens_hsa030604.72282694
3Parkinsons disease_Homo sapiens_hsa050123.82434725
4Sulfur metabolism_Homo sapiens_hsa009203.21172873
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.10082147
6Alzheimers disease_Homo sapiens_hsa050103.04599356
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.50136330
8Huntingtons disease_Homo sapiens_hsa050162.48368288
9Collecting duct acid secretion_Homo sapiens_hsa049662.47364810
10Vibrio cholerae infection_Homo sapiens_hsa051102.24763936
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74559134
12Folate biosynthesis_Homo sapiens_hsa007901.72783594
13Synaptic vesicle cycle_Homo sapiens_hsa047211.70732341
14Proteasome_Homo sapiens_hsa030501.65404590
15Fatty acid elongation_Homo sapiens_hsa000621.62384571
16Histidine metabolism_Homo sapiens_hsa003401.59037115
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40768264
18Phenylalanine metabolism_Homo sapiens_hsa003601.31819099
19Cardiac muscle contraction_Homo sapiens_hsa042601.27953663
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26764904
21Ribosome_Homo sapiens_hsa030101.26153606
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24790609
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23641182
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22973598
25Tyrosine metabolism_Homo sapiens_hsa003501.22197096
26Butanoate metabolism_Homo sapiens_hsa006501.20709962
27Other glycan degradation_Homo sapiens_hsa005111.20227170
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19786965
29Pyruvate metabolism_Homo sapiens_hsa006201.16632694
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12759530
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11532383
32Steroid biosynthesis_Homo sapiens_hsa001001.11093210
33Mineral absorption_Homo sapiens_hsa049781.10958050
34Insulin secretion_Homo sapiens_hsa049111.04452555
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03429397
36Linoleic acid metabolism_Homo sapiens_hsa005910.98885948
37Peroxisome_Homo sapiens_hsa041460.95798965
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.95765995
39Sulfur relay system_Homo sapiens_hsa041220.93360060
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92737629
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91906628
42Regulation of autophagy_Homo sapiens_hsa041400.91580678
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91173211
44Nicotine addiction_Homo sapiens_hsa050330.90142458
45Tryptophan metabolism_Homo sapiens_hsa003800.89532841
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88172046
47Metabolic pathways_Homo sapiens_hsa011000.88112558
48Cocaine addiction_Homo sapiens_hsa050300.87302444
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86795553
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86257343
51GABAergic synapse_Homo sapiens_hsa047270.85861222
52Taste transduction_Homo sapiens_hsa047420.85024142
53Lysosome_Homo sapiens_hsa041420.84453632
54RNA polymerase_Homo sapiens_hsa030200.83620391
55Pancreatic secretion_Homo sapiens_hsa049720.83180544
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82552673
57N-Glycan biosynthesis_Homo sapiens_hsa005100.81845121
58Rheumatoid arthritis_Homo sapiens_hsa053230.81092004
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80958949
60Propanoate metabolism_Homo sapiens_hsa006400.80791036
61Chemical carcinogenesis_Homo sapiens_hsa052040.80519025
62Amphetamine addiction_Homo sapiens_hsa050310.80475576
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80393573
64Ether lipid metabolism_Homo sapiens_hsa005650.80386892
65Serotonergic synapse_Homo sapiens_hsa047260.79871853
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77899985
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77389509
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76017990
69Sphingolipid metabolism_Homo sapiens_hsa006000.73624332
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.73022953
71Retinol metabolism_Homo sapiens_hsa008300.71842595
72Fat digestion and absorption_Homo sapiens_hsa049750.71416235
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70060550
74Arginine and proline metabolism_Homo sapiens_hsa003300.69597779
75beta-Alanine metabolism_Homo sapiens_hsa004100.68563798
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68205347
77Caffeine metabolism_Homo sapiens_hsa002320.68077092
78Phagosome_Homo sapiens_hsa041450.67415857
79Vitamin B6 metabolism_Homo sapiens_hsa007500.66866335
80Glutathione metabolism_Homo sapiens_hsa004800.66153413
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65928523
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65052187
83Arachidonic acid metabolism_Homo sapiens_hsa005900.63252287
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63123364
85Purine metabolism_Homo sapiens_hsa002300.61674181
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61032107
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58986865
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58786350
89Arginine biosynthesis_Homo sapiens_hsa002200.55782035
90Dopaminergic synapse_Homo sapiens_hsa047280.55027584
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.54186957
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.52309372
93Morphine addiction_Homo sapiens_hsa050320.51719532
94Asthma_Homo sapiens_hsa053100.50639779
95Starch and sucrose metabolism_Homo sapiens_hsa005000.50467566
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50433991
97Carbon metabolism_Homo sapiens_hsa012000.49787364
98Circadian entrainment_Homo sapiens_hsa047130.49159353
99Type I diabetes mellitus_Homo sapiens_hsa049400.49073973
100Galactose metabolism_Homo sapiens_hsa000520.48774031
101Prion diseases_Homo sapiens_hsa050200.47758774
102Olfactory transduction_Homo sapiens_hsa047400.46417665
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45729827
104Pyrimidine metabolism_Homo sapiens_hsa002400.45204299
105Fructose and mannose metabolism_Homo sapiens_hsa000510.44115907
106Pentose phosphate pathway_Homo sapiens_hsa000300.41073697
107Homologous recombination_Homo sapiens_hsa034400.40565049
108Glutamatergic synapse_Homo sapiens_hsa047240.39764082
109Thyroid hormone synthesis_Homo sapiens_hsa049180.38236959
110Fatty acid degradation_Homo sapiens_hsa000710.37006989
111Base excision repair_Homo sapiens_hsa034100.36694016
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.35591823
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.34425381
114Complement and coagulation cascades_Homo sapiens_hsa046100.32829796
115One carbon pool by folate_Homo sapiens_hsa006700.30859949
116Nitrogen metabolism_Homo sapiens_hsa009100.30856530
117Fatty acid metabolism_Homo sapiens_hsa012120.30631884
118Cholinergic synapse_Homo sapiens_hsa047250.29317882
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29107095
120Phototransduction_Homo sapiens_hsa047440.28587777
121RNA degradation_Homo sapiens_hsa030180.24884685
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24652236
123PPAR signaling pathway_Homo sapiens_hsa033200.23225145
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.22711252
125Biosynthesis of amino acids_Homo sapiens_hsa012300.21783320

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »