FKBP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.04429096
2protein heterotrimerization (GO:0070208)6.84263130
3chondrocyte proliferation (GO:0035988)6.43346871
4bone trabecula formation (GO:0060346)5.72109890
5sequestering of extracellular ligand from receptor (GO:0035581)5.41996040
6endodermal cell differentiation (GO:0035987)5.18430013
7skin morphogenesis (GO:0043589)5.12011353
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.86348721
9collagen metabolic process (GO:0032963)4.57872825
10collagen catabolic process (GO:0030574)4.49276869
11wound healing, spreading of epidermal cells (GO:0035313)4.34991002
12multicellular organismal macromolecule metabolic process (GO:0044259)4.24913957
13negative regulation of fatty acid transport (GO:2000192)4.21677021
14positive regulation of endothelial cell apoptotic process (GO:2000353)4.20178624
15dermatan sulfate biosynthetic process (GO:0030208)4.13913114
16neuron projection extension involved in neuron projection guidance (GO:1902284)4.13727235
17axon extension involved in axon guidance (GO:0048846)4.13727235
18multicellular organismal catabolic process (GO:0044243)4.08923265
19cell adhesion mediated by integrin (GO:0033627)4.08683769
20peptidyl-proline hydroxylation (GO:0019511)4.00939834
21multicellular organismal metabolic process (GO:0044236)3.98452731
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94933699
23extracellular matrix disassembly (GO:0022617)3.89670546
24basement membrane organization (GO:0071711)3.87595045
25extracellular fibril organization (GO:0043206)3.79445871
26mesenchymal-epithelial cell signaling (GO:0060638)3.77357086
27dermatan sulfate metabolic process (GO:0030205)3.74644571
28metanephric mesenchyme development (GO:0072075)3.73660453
29negative regulation of chondrocyte differentiation (GO:0032331)3.72165570
30craniofacial suture morphogenesis (GO:0097094)3.67477511
31chondrocyte development (GO:0002063)3.67359241
32regulation of tight junction assembly (GO:2000810)3.64252632
33kidney mesenchyme development (GO:0072074)3.63041205
34fibril organization (GO:0097435)3.59167489
35cellular response to vitamin (GO:0071295)3.57507135
36positive regulation of epithelial to mesenchymal transition (GO:0010718)3.56459361
37epithelial cell-cell adhesion (GO:0090136)3.56386106
38wound healing, spreading of cells (GO:0044319)3.55955594
39protein hydroxylation (GO:0018126)3.54335735
40cellular response to vitamin D (GO:0071305)3.52931195
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51482444
42cell-substrate junction assembly (GO:0007044)3.46197824
43Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.45643888
44outer ear morphogenesis (GO:0042473)3.45143815
45endothelial cell morphogenesis (GO:0001886)3.41412363
46hemidesmosome assembly (GO:0031581)3.40286578
47plasma membrane repair (GO:0001778)3.39262202
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.35380086
49convergent extension (GO:0060026)3.32264506
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32110463
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32061593
52apoptotic cell clearance (GO:0043277)3.31693482
53regulation of plasminogen activation (GO:0010755)3.30173412
54keratan sulfate catabolic process (GO:0042340)3.29207819
55protein retention in ER lumen (GO:0006621)3.29121218
56regulation of establishment of planar polarity (GO:0090175)3.28392774
57cochlea morphogenesis (GO:0090103)3.28217005
58hippo signaling (GO:0035329)3.27751885
59extracellular matrix assembly (GO:0085029)3.26525854
60vascular endothelial growth factor signaling pathway (GO:0038084)3.26363300
61endocardial cushion development (GO:0003197)3.25068295
62COPI coating of Golgi vesicle (GO:0048205)3.23563291
63Golgi transport vesicle coating (GO:0048200)3.23563291
64cell migration involved in heart development (GO:0060973)3.22348914
65negative regulation of cartilage development (GO:0061037)3.18418612
66extracellular matrix organization (GO:0030198)3.16585226
67extracellular structure organization (GO:0043062)3.15432207
68paraxial mesoderm development (GO:0048339)3.15081549
69retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09763678
70tooth mineralization (GO:0034505)3.07952759
71cell-substrate adherens junction assembly (GO:0007045)3.07888429
72focal adhesion assembly (GO:0048041)3.07888429
73establishment of apical/basal cell polarity (GO:0035089)3.07339448
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05969814
75positive regulation of cartilage development (GO:0061036)3.05134845
76positive regulation of extracellular matrix organization (GO:1903055)3.04992627
77protein localization to cell surface (GO:0034394)3.03791407
78glomerular basement membrane development (GO:0032836)3.02173362
79embryonic cranial skeleton morphogenesis (GO:0048701)3.01232315
80regulation of cartilage development (GO:0061035)2.98784203
81substrate adhesion-dependent cell spreading (GO:0034446)2.97370408
82positive regulation of blood vessel endothelial cell migration (GO:0043536)2.96206342
83extracellular negative regulation of signal transduction (GO:1900116)2.96137636
84extracellular regulation of signal transduction (GO:1900115)2.96137636
85polarized epithelial cell differentiation (GO:0030859)2.96073036
86type B pancreatic cell proliferation (GO:0044342)2.94300256
87negative regulation of embryonic development (GO:0045992)2.94240069
88cellular response to interferon-alpha (GO:0035457)2.93270866
89middle ear morphogenesis (GO:0042474)2.91980163
90stress fiber assembly (GO:0043149)2.91332292
91heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.88560452
92notochord development (GO:0030903)2.87269760
93cell migration involved in sprouting angiogenesis (GO:0002042)2.86750573
94cranial suture morphogenesis (GO:0060363)2.85481753
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.85249828
96negative regulation of catenin import into nucleus (GO:0035414)2.84737279
97embryonic skeletal joint morphogenesis (GO:0060272)2.84242386
98semaphorin-plexin signaling pathway (GO:0071526)2.83288095
99positive regulation of osteoblast proliferation (GO:0033690)2.82972885
100trabecula formation (GO:0060343)2.81873436
101replacement ossification (GO:0036075)2.80424645
102endochondral ossification (GO:0001958)2.80424645
103regulation of SMAD protein import into nucleus (GO:0060390)2.78438898
104regulation of chondrocyte differentiation (GO:0032330)2.78304906
105non-canonical Wnt signaling pathway (GO:0035567)2.77725944
106cell proliferation involved in metanephros development (GO:0072203)2.77063169
107epithelial to mesenchymal transition (GO:0001837)2.76930547
108chondroitin sulfate biosynthetic process (GO:0030206)2.76210319
109positive regulation of stem cell differentiation (GO:2000738)2.75873699
110muscle cell migration (GO:0014812)2.75409329
111negative regulation of smooth muscle cell migration (GO:0014912)2.74661569
112regulation of extracellular matrix disassembly (GO:0010715)2.72982252
113peptidyl-glutamic acid carboxylation (GO:0017187)2.72977364
114protein carboxylation (GO:0018214)2.72977364
115cellular response to amino acid stimulus (GO:0071230)2.70630834
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70495780
117adhesion of symbiont to host (GO:0044406)2.67101932
118regulation of gastrulation (GO:0010470)2.64568132
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64395580
120adherens junction assembly (GO:0034333)2.63595542
121substrate-dependent cell migration (GO:0006929)2.62664488
122positive regulation of smoothened signaling pathway (GO:0045880)2.62430798
123blood vessel endothelial cell migration (GO:0043534)2.61226627
124regulation of early endosome to late endosome transport (GO:2000641)2.60819036
125proline biosynthetic process (GO:0006561)2.60735808
126regulation of integrin-mediated signaling pathway (GO:2001044)2.60465632
127mesodermal cell differentiation (GO:0048333)2.55169234
128activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52727251
129heparan sulfate proteoglycan metabolic process (GO:0030201)2.47005592
130venous blood vessel morphogenesis (GO:0048845)2.46964153
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.45676546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.97880134
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.04968671
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.36854742
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.12757558
5CLOCK_20551151_ChIP-Seq_293T_Human3.39280337
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.39173693
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.99372080
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81496980
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77507480
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.71267689
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.67605667
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.60224246
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.40712946
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39514613
15ZNF263_19887448_ChIP-Seq_K562_Human2.35443875
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34834072
17BRD4_25478319_ChIP-Seq_HGPS_Human2.32751241
18CJUN_26792858_Chip-Seq_BT549_Human2.31331688
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.29229827
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25742831
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25510386
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23677107
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.19599831
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03350525
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.97339257
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92408322
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.85317996
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83330302
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82379480
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.79235368
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77462510
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74312439
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74312439
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67968641
35ATF3_27146783_Chip-Seq_COLON_Human1.66063760
36KDM2B_26808549_Chip-Seq_K562_Human1.65919715
37SMC1_22415368_ChIP-Seq_MEFs_Mouse1.64962895
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.63829228
39TP53_22127205_ChIP-Seq_IMR90_Human1.63812167
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.62949627
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62626830
42* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58514088
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55688152
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.54935134
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52458667
46* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50937030
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50495014
48MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.49885425
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48951429
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48951429
51* TP53_23651856_ChIP-Seq_MEFs_Mouse1.43496645
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43321231
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.41298037
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40712853
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37527683
56JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35071539
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32376841
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31098162
59RACK7_27058665_Chip-Seq_MCF-7_Human1.30925141
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30835854
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30703031
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30618016
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30560480
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30095858
65* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29443468
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29154539
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28974538
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.27839129
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27144725
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.26106565
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23712473
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22969558
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.20311598
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20272143
75TP53_18474530_ChIP-ChIP_U2OS_Human1.20197824
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18614780
77* TBX20_22328084_ChIP-Seq_HEART_Mouse1.17558934
78* TBX20_22080862_ChIP-Seq_HEART_Mouse1.17558934
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16614970
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.16119659
81TP53_16413492_ChIP-PET_HCT116_Human1.15729828
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14589882
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13046652
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12997996
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12424682
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.11998573
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11951783
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11662946
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11435816
90AR_21909140_ChIP-Seq_LNCAP_Human1.11054974
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.10956018
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08958922
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08438417
94SOX2_20726797_ChIP-Seq_SW620_Human1.07950668
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07821414
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07719257
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07699998
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07189090
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06682029
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.06516217
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.03824457
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03797065
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.03574221
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03000861
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02750847
106KDM2B_26808549_Chip-Seq_DND41_Human1.01642062
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01641375
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01422985
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01367170
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01180058
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00028345
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99131783
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.98358700
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98345106
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96954123
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96889223
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96025306
118NFI_21473784_ChIP-Seq_ESCs_Mouse0.95537473
119LXR_22292898_ChIP-Seq_THP-1_Human0.94482371
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94044070
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94040490
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93649539
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90119795
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.89216921
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88996003
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86491411
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85758042
128EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85758042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.53547208
2MP0005503_abnormal_tendon_morphology5.19001793
3MP0005275_abnormal_skin_tensile4.72112017
4MP0003705_abnormal_hypodermis_morpholog4.11812614
5MP0003279_aneurysm4.01133727
6MP0004272_abnormal_basement_membrane2.98084227
7MP0001958_emphysema2.84170304
8MP0005623_abnormal_meninges_morphology2.75693413
9MP0009384_cardiac_valve_regurgitation2.63836696
10MP0010030_abnormal_orbit_morphology2.58993787
11MP0006054_spinal_hemorrhage2.55059107
12MP0005508_abnormal_skeleton_morphology2.28537674
13MP0004858_abnormal_nervous_system2.19029950
14MP0003566_abnormal_cell_adhesion2.16802619
15MP0005257_abnormal_intraocular_pressure2.08686373
16MP0009250_abnormal_appendicular_skeleto2.05759602
17MP0001542_abnormal_bone_strength2.01120354
18MP0005023_abnormal_wound_healing1.92051470
19MP0003385_abnormal_body_wall1.85839684
20MP0010352_gastrointestinal_tract_polyps1.81043786
21MP0002060_abnormal_skin_morphology1.74579973
22MP0003091_abnormal_cell_migration1.68659690
23MP0002896_abnormal_bone_mineralization1.63707020
24MP0002295_abnormal_pulmonary_circulatio1.62894621
25MP0004134_abnormal_chest_morphology1.62523744
26MP0002108_abnormal_muscle_morphology1.60565583
27MP0002282_abnormal_trachea_morphology1.60441036
28MP0000733_abnormal_muscle_development1.58854693
29MP0009053_abnormal_anal_canal1.52734296
30MP0010368_abnormal_lymphatic_system1.51309985
31MP0001243_abnormal_dermal_layer1.50548186
32MP0003942_abnormal_urinary_system1.48284154
33MP0005171_absent_coat_pigmentation1.48124860
34MP0001299_abnormal_eye_distance/1.42050032
35MP0000013_abnormal_adipose_tissue1.41834078
36MP0000163_abnormal_cartilage_morphology1.39588673
37MP0000767_abnormal_smooth_muscle1.39074473
38MP0002115_abnormal_skeleton_extremities1.34351329
39MP0002932_abnormal_joint_morphology1.34060450
40MP0005390_skeleton_phenotype1.27775564
41MP0002933_joint_inflammation1.26355437
42MP0000534_abnormal_ureter_morphology1.25367431
43MP0000428_abnormal_craniofacial_morphol1.24548361
44MP0000751_myopathy1.23079011
45MP0003283_abnormal_digestive_organ1.21098390
46MP0000750_abnormal_muscle_regeneration1.19960643
47MP0000049_abnormal_middle_ear1.16974481
48MP0003755_abnormal_palate_morphology1.16693327
49MP0002113_abnormal_skeleton_development1.16481767
50MP0009780_abnormal_chondrocyte_physiolo1.15468839
51MP0003115_abnormal_respiratory_system1.15186630
52MP0005409_darkened_coat_color1.15031591
53MP0003941_abnormal_skin_development1.09771254
54MP0002249_abnormal_larynx_morphology1.03482916
55MP0002089_abnormal_postnatal_growth/wei1.03256790
56MP0003937_abnormal_limbs/digits/tail_de0.99308783
57MP0002109_abnormal_limb_morphology0.99279461
58MP0001348_abnormal_lacrimal_gland0.99142119
59MP0004084_abnormal_cardiac_muscle0.97597688
60MP0002877_abnormal_melanocyte_morpholog0.96717008
61MP0003935_abnormal_craniofacial_develop0.96341100
62MP0005058_abnormal_lysosome_morphology0.95640920
63MP0000432_abnormal_head_morphology0.94449816
64MP0002116_abnormal_craniofacial_bone0.93802863
65MP0000566_synostosis0.92708311
66MP0002233_abnormal_nose_morphology0.91491137
67MP0002128_abnormal_blood_circulation0.90040376
68MP0002111_abnormal_tail_morphology0.89880723
69MP0000537_abnormal_urethra_morphology0.89576973
70MP0003123_paternal_imprinting0.89169573
71MP0005076_abnormal_cell_differentiation0.89038711
72MP0001879_abnormal_lymphatic_vessel0.89008096
73MP0000762_abnormal_tongue_morphology0.88251148
74MP0001614_abnormal_blood_vessel0.85630318
75MP0002998_abnormal_bone_remodeling0.85525094
76MP0003122_maternal_imprinting0.84549815
77MP0004233_abnormal_muscle_weight0.83087798
78MP0002168_other_aberrant_phenotype0.81945329
79MP0003795_abnormal_bone_structure0.81904051
80MP0000749_muscle_degeneration0.80789209
81MP0005367_renal/urinary_system_phenotyp0.80466717
82MP0000516_abnormal_urinary_system0.80466717
83MP0000462_abnormal_digestive_system0.79770441
84MP0002092_abnormal_eye_morphology0.79736161
85MP0001915_intracranial_hemorrhage0.79111259
86MP0000003_abnormal_adipose_tissue0.79090324
87MP0001661_extended_life_span0.78374986
88MP0002925_abnormal_cardiovascular_devel0.78364135
89MP0002114_abnormal_axial_skeleton0.77604245
90MP0000759_abnormal_skeletal_muscle0.77142731
91MP0004087_abnormal_muscle_fiber0.77007292
92MP0004197_abnormal_fetal_growth/weight/0.75099414
93MP0000467_abnormal_esophagus_morphology0.72879440
94MP0005595_abnormal_vascular_smooth0.72846311
95MP0001533_abnormal_skeleton_physiology0.71913811
96MP0003950_abnormal_plasma_membrane0.71571289
97MP0003045_fibrosis0.70729496
98MP0006138_congestive_heart_failure0.70406080
99MP0001175_abnormal_lung_morphology0.69325849
100MP0001270_distended_abdomen0.65817218
101MP0008007_abnormal_cellular_replicative0.64607379
102MP0002085_abnormal_embryonic_tissue0.64529342
103MP0002697_abnormal_eye_size0.63489021
104MP0005193_abnormal_anterior_eye0.62512755
105MP0010630_abnormal_cardiac_muscle0.61996756
106MP0000678_abnormal_parathyroid_gland0.60067795
107MP0002177_abnormal_outer_ear0.59997629
108MP0005369_muscle_phenotype0.59629411
109MP0002084_abnormal_developmental_patter0.58888545
110MP0000266_abnormal_heart_morphology0.58777421
111MP0000579_abnormal_nail_morphology0.58548707
112MP0001849_ear_inflammation0.57865291
113MP0005164_abnormal_response_to0.57253631
114MP0002938_white_spotting0.56173297
115MP0001340_abnormal_eyelid_morphology0.55907361
116MP0005197_abnormal_uvea_morphology0.55754993
117MP0001286_abnormal_eye_development0.54696934

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.01072745
2* Protrusio acetabuli (HP:0003179)7.81106856
3Aortic dissection (HP:0002647)4.74532832
4Shallow orbits (HP:0000586)4.55675290
5Ankle contracture (HP:0006466)4.50916363
6Soft skin (HP:0000977)4.48466617
7Peritonitis (HP:0002586)4.45982246
8Neonatal short-limb short stature (HP:0008921)4.34780205
9Atrophic scars (HP:0001075)4.34768754
10Bladder diverticulum (HP:0000015)3.98366348
11Dilatation of the ascending aorta (HP:0005111)3.74293546
12Fragile skin (HP:0001030)3.72970490
13Cervical subluxation (HP:0003308)3.70015597
14Aortic aneurysm (HP:0004942)3.66535056
15Broad metatarsal (HP:0001783)3.62704849
16Cerebral aneurysm (HP:0004944)3.59263548
17Genu recurvatum (HP:0002816)3.55489828
18* Abnormality of dentin (HP:0010299)3.47987339
19Type 1 muscle fiber predominance (HP:0003803)3.33428072
20Spinal rigidity (HP:0003306)3.29869760
21Follicular hyperkeratosis (HP:0007502)3.23224263
22* Wormian bones (HP:0002645)3.14232087
23Mitral valve prolapse (HP:0001634)3.11657165
24* Blue sclerae (HP:0000592)3.08914198
25Wrist flexion contracture (HP:0001239)2.86180677
26Bowel diverticulosis (HP:0005222)2.85037291
27Increased connective tissue (HP:0009025)2.83087067
28* Biconcave vertebral bodies (HP:0004586)2.76062116
29Vascular tortuosity (HP:0004948)2.65892428
30Abnormal delivery (HP:0001787)2.63347961
31Hyperextensible skin (HP:0000974)2.59048453
32Disproportionate tall stature (HP:0001519)2.58499025
33Renal duplication (HP:0000075)2.57980801
34Mesomelia (HP:0003027)2.56701851
35Overgrowth (HP:0001548)2.50736521
36Elbow flexion contracture (HP:0002987)2.50409325
37Mild short stature (HP:0003502)2.46866077
38Hyperacusis (HP:0010780)2.45969061
39Osteoarthritis (HP:0002758)2.45871521
40Breech presentation (HP:0001623)2.44650432
41Ectopia lentis (HP:0001083)2.44302254
42Infantile muscular hypotonia (HP:0008947)2.43984232
43* Abnormality of the acetabulum (HP:0003170)2.42664765
44Mildly elevated creatine phosphokinase (HP:0008180)2.40517495
45Slender build (HP:0001533)2.38668747
46Ulnar bowing (HP:0003031)2.38434184
47Wide anterior fontanel (HP:0000260)2.38241183
48* Vertebral compression fractures (HP:0002953)2.35903822
49Deviation of the hallux (HP:0010051)2.35801591
50Arterial tortuosity (HP:0005116)2.30930091
51Nonimmune hydrops fetalis (HP:0001790)2.30189600
52Hallux valgus (HP:0001822)2.27764042
53Hypoventilation (HP:0002791)2.27484997
54Increased variability in muscle fiber diameter (HP:0003557)2.24424520
55Abnormality of the calcaneus (HP:0008364)2.23498298
56Short nail (HP:0001799)2.22453989
57Broad long bones (HP:0005622)2.21556406
58Aortic regurgitation (HP:0001659)2.19496183
59Epiphyseal dysplasia (HP:0002656)2.19307648
60Tibial bowing (HP:0002982)2.18925660
61Abnormality of the peritoneum (HP:0002585)2.18632842
62Hypoplastic ischia (HP:0003175)2.17867918
63Cupped ribs (HP:0000887)2.17045650
64* Joint laxity (HP:0001388)2.16762546
65Aneurysm (HP:0002617)2.16699840
66Short 4th metacarpal (HP:0010044)2.16563856
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16563856
68Premature skin wrinkling (HP:0100678)2.16345884
69Radial bowing (HP:0002986)2.15756361
70Broad ribs (HP:0000885)2.13753556
71Camptodactyly of toe (HP:0001836)2.13106529
72Achilles tendon contracture (HP:0001771)2.12618608
73Inguinal hernia (HP:0000023)2.08283095
74Mitral regurgitation (HP:0001653)2.07586799
75* Platyspondyly (HP:0000926)2.04430969
76Osteolytic defects of the hand bones (HP:0009699)2.03661200
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.03661200
78Thin bony cortex (HP:0002753)2.03450114
79Spinal cord compression (HP:0002176)2.02022703
80Femoral bowing (HP:0002980)2.01202174
81Protruding ear (HP:0000411)2.00138521
82Decreased skull ossification (HP:0004331)1.98733666
83Hip contracture (HP:0003273)1.98386470
84Knee flexion contracture (HP:0006380)1.98126714
85Abnormality of skeletal muscle fiber size (HP:0012084)1.98058239
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97594420
87Natal tooth (HP:0000695)1.97210238
88Abnormality of the Achilles tendon (HP:0005109)1.96008262
89Bell-shaped thorax (HP:0001591)1.95703897
90Turricephaly (HP:0000262)1.95038550
91* Coxa vara (HP:0002812)1.95004036
92Bowed forearm bones (HP:0003956)1.94002670
93Bowing of the arm (HP:0006488)1.94002670
94Round ear (HP:0100830)1.92054150
95Mitral stenosis (HP:0001718)1.91713029
96Morphological abnormality of the middle ear (HP:0008609)1.91634124
97Buphthalmos (HP:0000557)1.91031534
98Distal upper limb amyotrophy (HP:0007149)1.90836133
99Upper limb amyotrophy (HP:0009129)1.90836133
100Abnormality of carpal bone ossification (HP:0006257)1.90733450
101Abnormality of the ischium (HP:0003174)1.87681354
102Flat cornea (HP:0007720)1.87015327
103Asymmetry of the thorax (HP:0001555)1.87009209
104Generalized amyotrophy (HP:0003700)1.86890131
105Scapular winging (HP:0003691)1.86321215
106Abnormal ossification of hand bones (HP:0005921)1.84420621
107Spondylolisthesis (HP:0003302)1.84027883
108Syringomyelia (HP:0003396)1.82550235
109Spinal cord lesions (HP:0100561)1.82550235
110Deep venous thrombosis (HP:0002625)1.81268768
111Arnold-Chiari malformation (HP:0002308)1.80388367
112Abnormality of skull ossification (HP:0002703)1.79940245
113Renovascular hypertension (HP:0100817)1.79811736
114Beaking of vertebral bodies (HP:0004568)1.78775124
115Difficulty climbing stairs (HP:0003551)1.78555913
116Increased density of long bones (HP:0006392)1.78374077
117Coronal craniosynostosis (HP:0004440)1.78194796
118Delayed cranial suture closure (HP:0000270)1.78105799
119Insomnia (HP:0100785)1.77558056
120Calcaneovalgus deformity (HP:0001848)1.76977624
121Joint stiffness (HP:0001387)1.76888080
122Long toe (HP:0010511)1.76692495
123Broad phalanx (HP:0006009)1.75661195
124Arachnodactyly (HP:0001166)1.75658378
125Hand muscle atrophy (HP:0009130)1.75483612
126Thin ribs (HP:0000883)1.74493920
127Aortic valve stenosis (HP:0001650)1.71111034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.16037701
2TRIB34.44108085
3TTN4.06770781
4LATS23.49061563
5PDGFRA3.19425608
6PKN23.13839380
7LATS12.98075609
8FGFR42.28022725
9ERN12.27319437
10PAK22.18088066
11EPHB22.12523220
12SMG12.09347145
13TESK11.99211275
14SIK11.76273340
15LIMK11.74465301
16STK38L1.71745223
17PTK21.65412463
18BMX1.59944675
19TRPM71.58870053
20RIPK11.58815854
21RPS6KA41.56732233
22LRRK21.44701642
23PAK41.44573646
24PIM21.43611335
25PAK31.42804688
26TYRO31.42642188
27MYLK1.41969134
28PTK2B1.41464293
29STK31.38833320
30PTK61.36688375
31EEF2K1.33180743
32FER1.32706075
33MET1.31479946
34ILK1.29966975
35FGFR11.27606428
36MOS1.27541887
37ERBB41.26962459
38MST1R1.26560255
39EPHA21.25346303
40MAP3K101.20209432
41MAP3K31.18588054
42ROCK11.17897495
43DMPK1.17824126
44IRAK31.16371593
45EPHA31.09839832
46NME21.04287387
47KDR1.03873936
48TESK21.02997415
49TGFBR11.01528662
50AKT31.01032183
51STK381.00765423
52MTOR0.99817633
53PDGFRB0.93373744
54PIK3CA0.92603325
55ERBB30.92114783
56RPS6KA20.89285122
57TGFBR20.88412882
58PIK3CG0.83767258
59WNK10.82645146
60CDK80.82080142
61NEK90.81638432
62WNK40.80431249
63FLT30.79268470
64PAK10.76315157
65ROCK20.75869820
66MAP2K10.74930442
67ARAF0.74249708
68PRKD30.73563205
69PLK20.72467333
70DAPK30.67864806
71CDC42BPA0.66022451
72MAP2K30.64281327
73MAP3K80.64033241
74TAOK20.63176234
75PRKG20.61112115
76KSR20.60823064
77MAP3K60.60291906
78FGFR30.58966422
79NEK10.57848305
80SCYL20.57223301
81CAMK1G0.54761695
82CDK60.53645613
83FGFR20.52016923
84STK100.51970465
85INSR0.51056616
86BRAF0.51051730
87PRKD10.50641501
88TAOK10.50542400
89PRPF4B0.50074314
90RPS6KC10.49943219
91RPS6KL10.49943219
92MARK20.49500147
93MAPKAPK30.49124367
94NTRK10.48789853
95BUB10.46162457
96MAP3K70.45524094
97PRKD20.44041996
98PAK60.43064261
99CDK140.42816506
100PDPK10.42009582
101MELK0.41548044
102ABL20.41235327
103BRSK10.40830716
104CDK120.39326199
105RET0.39125751
106CDK150.38643227
107LMTK20.38184210
108GSK3A0.37828192
109CDK70.37312326
110CDK90.36772512
111CAMK1D0.34699819
112MKNK10.34379808
113NEK20.34307400
114CDK180.33904292
115DYRK1B0.33581611
116ADRBK10.33312979
117SRC0.32908557
118PLK30.32532968
119CDK11A0.32460812
120EPHB10.32402642
121AKT20.32353300
122RPS6KA60.32251743
123MAPK110.32054425
124TTK0.31057338
125CLK10.29873393
126TIE10.29501292
127CAMKK10.29293018
128AURKB0.28835121
129RPS6KB20.28740083
130STK240.28209393
131NUAK10.27303699
132FRK0.27283659
133MAPK10.27143546
134PDK20.24630339
135ICK0.24598805

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.93614744
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.60662293
3Focal adhesion_Homo sapiens_hsa045103.43756673
4Protein digestion and absorption_Homo sapiens_hsa049742.91484705
5Proteoglycans in cancer_Homo sapiens_hsa052052.55765321
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35544223
7TGF-beta signaling pathway_Homo sapiens_hsa043502.31370854
8Bladder cancer_Homo sapiens_hsa052192.31361017
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.26531460
10Hippo signaling pathway_Homo sapiens_hsa043902.25957930
11Dilated cardiomyopathy_Homo sapiens_hsa054142.24296888
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.22799684
13Adherens junction_Homo sapiens_hsa045202.19882944
14Basal cell carcinoma_Homo sapiens_hsa052172.17509972
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.14169428
16Amoebiasis_Homo sapiens_hsa051462.09875740
17Malaria_Homo sapiens_hsa051441.96294511
18Small cell lung cancer_Homo sapiens_hsa052221.95827015
19MicroRNAs in cancer_Homo sapiens_hsa052061.94348083
20Hedgehog signaling pathway_Homo sapiens_hsa043401.84477700
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.81341263
22Other glycan degradation_Homo sapiens_hsa005111.75887942
23p53 signaling pathway_Homo sapiens_hsa041151.75713031
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61928849
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50338593
26Chronic myeloid leukemia_Homo sapiens_hsa052201.45425077
27Melanoma_Homo sapiens_hsa052181.43558673
28Prion diseases_Homo sapiens_hsa050201.39822787
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38645286
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26707625
31Tight junction_Homo sapiens_hsa045301.21776739
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21567706
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.21373746
34Shigellosis_Homo sapiens_hsa051311.20653982
35Biosynthesis of amino acids_Homo sapiens_hsa012301.20162369
36Viral myocarditis_Homo sapiens_hsa054161.20056861
37HTLV-I infection_Homo sapiens_hsa051661.14797505
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14330797
39Wnt signaling pathway_Homo sapiens_hsa043101.13001565
40Complement and coagulation cascades_Homo sapiens_hsa046101.12230015
41Pathways in cancer_Homo sapiens_hsa052001.11702941
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08969060
43Prostate cancer_Homo sapiens_hsa052151.05839077
44Cell cycle_Homo sapiens_hsa041101.05502131
45Rap1 signaling pathway_Homo sapiens_hsa040151.02153920
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.01369609
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.97309357
48HIF-1 signaling pathway_Homo sapiens_hsa040660.96080400
49Glioma_Homo sapiens_hsa052140.94223001
50Platelet activation_Homo sapiens_hsa046110.91482100
51Pentose phosphate pathway_Homo sapiens_hsa000300.89811228
52Pancreatic cancer_Homo sapiens_hsa052120.88082698
53Axon guidance_Homo sapiens_hsa043600.86240545
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84388974
55Sulfur relay system_Homo sapiens_hsa041220.83766463
56Viral carcinogenesis_Homo sapiens_hsa052030.82722616
57TNF signaling pathway_Homo sapiens_hsa046680.81774036
58Fructose and mannose metabolism_Homo sapiens_hsa000510.81337191
59Melanogenesis_Homo sapiens_hsa049160.80657290
60N-Glycan biosynthesis_Homo sapiens_hsa005100.78996278
61Colorectal cancer_Homo sapiens_hsa052100.76056211
62Notch signaling pathway_Homo sapiens_hsa043300.72981648
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72367218
64Phagosome_Homo sapiens_hsa041450.70233172
65Apoptosis_Homo sapiens_hsa042100.69343888
66Toxoplasmosis_Homo sapiens_hsa051450.68842694
67ErbB signaling pathway_Homo sapiens_hsa040120.68076149
68Gap junction_Homo sapiens_hsa045400.67704173
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65260066
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64953319
71One carbon pool by folate_Homo sapiens_hsa006700.63615516
72Insulin signaling pathway_Homo sapiens_hsa049100.62736719
73Renal cell carcinoma_Homo sapiens_hsa052110.60579098
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59859982
75Hepatitis B_Homo sapiens_hsa051610.59354574
76Vitamin B6 metabolism_Homo sapiens_hsa007500.59044705
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58932439
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57956205
79Thyroid cancer_Homo sapiens_hsa052160.57737551
80RNA transport_Homo sapiens_hsa030130.57643278
81Endometrial cancer_Homo sapiens_hsa052130.57030046
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.54462249
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53477363
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53028889
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52931853
86Salmonella infection_Homo sapiens_hsa051320.52427548
87mTOR signaling pathway_Homo sapiens_hsa041500.52310512
88Glucagon signaling pathway_Homo sapiens_hsa049220.50957628
89Estrogen signaling pathway_Homo sapiens_hsa049150.50447845
90Ovarian steroidogenesis_Homo sapiens_hsa049130.49432252
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48444204
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.45674311
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44737786
94Choline metabolism in cancer_Homo sapiens_hsa052310.44674354
95Steroid biosynthesis_Homo sapiens_hsa001000.44336001
96VEGF signaling pathway_Homo sapiens_hsa043700.43868000
97FoxO signaling pathway_Homo sapiens_hsa040680.42854438
98Renin-angiotensin system_Homo sapiens_hsa046140.42799035
99Carbon metabolism_Homo sapiens_hsa012000.42342929
100Ras signaling pathway_Homo sapiens_hsa040140.42282183
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40780087
102Endocytosis_Homo sapiens_hsa041440.40447342
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40407705
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40323580
105Thyroid hormone synthesis_Homo sapiens_hsa049180.40303213
106Arginine biosynthesis_Homo sapiens_hsa002200.39581830
107Lysosome_Homo sapiens_hsa041420.39526032
108Insulin resistance_Homo sapiens_hsa049310.36169859
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34667664
110AMPK signaling pathway_Homo sapiens_hsa041520.33159160
111Sphingolipid metabolism_Homo sapiens_hsa006000.32992951
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30587528
113GnRH signaling pathway_Homo sapiens_hsa049120.30535229
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.30530412
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30304236
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30043248
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.29965048
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27592084
119MAPK signaling pathway_Homo sapiens_hsa040100.26437074
120Non-small cell lung cancer_Homo sapiens_hsa052230.24957237
121Galactose metabolism_Homo sapiens_hsa000520.24390573
122Lysine degradation_Homo sapiens_hsa003100.24103298
123Arginine and proline metabolism_Homo sapiens_hsa003300.23721578
124Vibrio cholerae infection_Homo sapiens_hsa051100.21439579
125Legionellosis_Homo sapiens_hsa051340.21297627

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