FIS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.72825614
2central nervous system myelination (GO:0022010)7.72825614
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.86571407
4ATP synthesis coupled proton transport (GO:0015986)6.68135736
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.68135736
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.49459421
7protein neddylation (GO:0045116)5.62490926
8respiratory electron transport chain (GO:0022904)5.55928648
9fatty acid elongation (GO:0030497)5.52187214
10electron transport chain (GO:0022900)5.43844797
11branching involved in labyrinthine layer morphogenesis (GO:0060670)5.31376419
12chaperone-mediated protein transport (GO:0072321)5.07457641
13long-chain fatty acid biosynthetic process (GO:0042759)4.94478649
14protein complex biogenesis (GO:0070271)4.22762458
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.19497094
16NADH dehydrogenase complex assembly (GO:0010257)4.19497094
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19497094
18positive regulation of TOR signaling (GO:0032008)3.95699468
19myelination (GO:0042552)3.95282324
20ensheathment of neurons (GO:0007272)3.93896632
21axon ensheathment (GO:0008366)3.93896632
22substantia nigra development (GO:0021762)3.91838914
23mitochondrial respiratory chain complex assembly (GO:0033108)3.72647519
24hydrogen ion transmembrane transport (GO:1902600)3.59355985
25GPI anchor biosynthetic process (GO:0006506)3.57572720
26cholesterol biosynthetic process (GO:0006695)3.57102373
27negative regulation of protein localization to cell surface (GO:2000009)3.51436583
28ribosomal small subunit biogenesis (GO:0042274)3.43268845
29L-phenylalanine metabolic process (GO:0006558)3.42915408
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42915408
31heme biosynthetic process (GO:0006783)3.41116676
32translational elongation (GO:0006414)3.38954902
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37650550
34mannosylation (GO:0097502)3.36603966
35proton transport (GO:0015992)3.35238002
36water-soluble vitamin biosynthetic process (GO:0042364)3.33645504
37negative regulation of neurotransmitter transport (GO:0051589)3.30311292
38ATP biosynthetic process (GO:0006754)3.28422371
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28117412
40GTP biosynthetic process (GO:0006183)3.27050057
41GDP-mannose metabolic process (GO:0019673)3.26486702
42hydrogen transport (GO:0006818)3.26050861
43regulation of cell proliferation involved in kidney development (GO:1901722)3.24053357
44regulation of collateral sprouting (GO:0048670)3.22984741
45heme metabolic process (GO:0042168)3.22696943
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21631257
47heart process (GO:0003015)3.14655622
48heart contraction (GO:0060047)3.14655622
49sterol biosynthetic process (GO:0016126)3.14646833
50GPI anchor metabolic process (GO:0006505)3.14096015
51amyloid precursor protein metabolic process (GO:0042982)3.13302098
52oligodendrocyte differentiation (GO:0048709)3.13134056
53regulation of mitochondrial translation (GO:0070129)3.13030738
54presynaptic membrane organization (GO:0097090)3.11799582
55tetrapyrrole biosynthetic process (GO:0033014)3.11671556
56regulation of oxidative phosphorylation (GO:0002082)3.10129095
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.09498929
58L-phenylalanine catabolic process (GO:0006559)3.09498929
59cotranslational protein targeting to membrane (GO:0006613)3.08296422
60positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.07647344
61isoprenoid biosynthetic process (GO:0008299)3.07157943
62* establishment of protein localization to mitochondrion (GO:0072655)3.03158824
63viral life cycle (GO:0019058)3.01279172
64oxidative phosphorylation (GO:0006119)2.99920417
65presynaptic membrane assembly (GO:0097105)2.98627465
66protein targeting to ER (GO:0045047)2.97639989
67viral transcription (GO:0019083)2.97478615
68proteasome assembly (GO:0043248)2.96743532
69response to redox state (GO:0051775)2.96108134
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92482276
71protein localization to endoplasmic reticulum (GO:0070972)2.92285980
72NADH metabolic process (GO:0006734)2.92209814
73respiratory chain complex IV assembly (GO:0008535)2.91873448
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91568972
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.90912443
76regulation of dopamine metabolic process (GO:0042053)2.90496146
77regulation of catecholamine metabolic process (GO:0042069)2.90496146
78nucleotide transmembrane transport (GO:1901679)2.89108811
79* mitochondrial transport (GO:0006839)2.88239814
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86431962
81ATP hydrolysis coupled proton transport (GO:0015991)2.86431962
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86203238
83neural nucleus development (GO:0048857)2.84572651
84* protein localization to mitochondrion (GO:0070585)2.83387869
85neuron cell-cell adhesion (GO:0007158)2.80767211
86ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80492235
87signal peptide processing (GO:0006465)2.77958681
88cellular protein complex disassembly (GO:0043624)2.76565722
89amyloid precursor protein catabolic process (GO:0042987)2.76010466
90translational termination (GO:0006415)2.75854595
91porphyrin-containing compound biosynthetic process (GO:0006779)2.75602271
92glutathione derivative biosynthetic process (GO:1901687)2.73916945
93glutathione derivative metabolic process (GO:1901685)2.73916945
94regulation of skeletal muscle contraction (GO:0014819)2.73395081
95cellular component biogenesis (GO:0044085)2.72729998
96negative regulation of neurotransmitter secretion (GO:0046929)2.71632149
97preassembly of GPI anchor in ER membrane (GO:0016254)2.69491567
98positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.69488177
99myelin maintenance (GO:0043217)2.69153379
100protein maturation by protein folding (GO:0022417)2.68559171
101nucleoside triphosphate biosynthetic process (GO:0009142)2.66721939
102neurotransmitter uptake (GO:0001504)2.66275367
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.65284489
104glycerophospholipid catabolic process (GO:0046475)2.63201983
105phagosome maturation (GO:0090382)2.62697778
106neuronal action potential propagation (GO:0019227)2.62352118
107viral protein processing (GO:0019082)2.62341279
108* negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61294187
109inner mitochondrial membrane organization (GO:0007007)2.60503828
110establishment of mitochondrion localization (GO:0051654)2.59756785
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.58684808
112termination of RNA polymerase III transcription (GO:0006386)2.58684808
113cytochrome complex assembly (GO:0017004)2.58090718
114protein insertion into membrane (GO:0051205)2.57268191
115DNA deamination (GO:0045006)2.56992443
116peptidyl-cysteine modification (GO:0018198)2.55590249
117response to methylmercury (GO:0051597)2.55502478
118* mitochondrion morphogenesis (GO:0070584)2.55335456
119translation (GO:0006412)2.55233508
120C-terminal protein lipidation (GO:0006501)2.55221110
121long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.54374177
122muscle filament sliding (GO:0030049)2.53165781
123actin-myosin filament sliding (GO:0033275)2.53165781
124porphyrin-containing compound metabolic process (GO:0006778)2.52690982
125dopamine biosynthetic process (GO:0042416)2.52377082
126negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.52013709
127astrocyte development (GO:0014002)2.51498970
128hydrogen peroxide catabolic process (GO:0042744)2.50611353
129positive regulation of action potential (GO:0045760)2.49684675
130sequestering of actin monomers (GO:0042989)2.49411200
131cullin deneddylation (GO:0010388)2.48945462
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48210279
133glycolipid biosynthetic process (GO:0009247)2.46070646
134* protein targeting to mitochondrion (GO:0006626)2.45954123
135UTP biosynthetic process (GO:0006228)2.45922103
136positive regulation of protein homodimerization activity (GO:0090073)2.45403181
137ribosomal small subunit assembly (GO:0000028)2.44505600
138metallo-sulfur cluster assembly (GO:0031163)2.44057870
139iron-sulfur cluster assembly (GO:0016226)2.44057870
140regulation of cellular amino acid metabolic process (GO:0006521)2.44037401
141negative regulation of execution phase of apoptosis (GO:1900118)2.43698795
142regulation of cellular respiration (GO:0043457)2.41582845
143response to misfolded protein (GO:0051788)2.41347457
144protein targeting to membrane (GO:0006612)2.41144765
145regulation of cholesterol storage (GO:0010885)2.40817483
146protein deneddylation (GO:0000338)2.39939363
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39773777
148aerobic respiration (GO:0009060)2.39580944
149aldehyde catabolic process (GO:0046185)2.38649364
150nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.37859766
151guanosine-containing compound biosynthetic process (GO:1901070)2.37677141
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.37645596
153creatine metabolic process (GO:0006600)2.37265152
154translational initiation (GO:0006413)2.36892617
155dopamine transport (GO:0015872)2.36695852
156intracellular protein transmembrane import (GO:0044743)2.36219341
157base-excision repair, AP site formation (GO:0006285)2.35814829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.92884280
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.14865290
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.87699843
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26421602
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91945888
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89760530
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.79427330
8EZH2_22144423_ChIP-Seq_EOC_Human2.72046864
9* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57268853
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40415241
11GBX2_23144817_ChIP-Seq_PC3_Human2.39681446
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38142495
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37541338
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.36502734
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.32196274
16TAF15_26573619_Chip-Seq_HEK293_Human2.32085886
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.31390361
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18739313
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17741331
20TET1_21451524_ChIP-Seq_MESCs_Mouse2.05465180
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02154366
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98876569
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98540213
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97600223
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96480421
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95821857
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.91594886
28VDR_22108803_ChIP-Seq_LS180_Human1.90467588
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89410390
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87864096
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83586235
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81025211
33XRN2_22483619_ChIP-Seq_HELA_Human1.78881637
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77746500
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71477075
36* ETS1_20019798_ChIP-Seq_JURKAT_Human1.70934502
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65835963
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65322836
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65035145
40LXR_22292898_ChIP-Seq_THP-1_Human1.63637696
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.61715548
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61303631
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.58990674
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57922831
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57285153
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56980323
47* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56448776
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56375601
49SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.55542649
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54981203
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.53955342
52* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52937673
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50889028
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50866148
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.50817936
56P68_20966046_ChIP-Seq_HELA_Human1.49789819
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49265211
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48928891
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47559833
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.46986491
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45438049
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.45167203
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43530857
64* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42390820
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40902513
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40902513
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40314255
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38297594
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.36953289
70GABP_19822575_ChIP-Seq_HepG2_Human1.36504289
71* ER_23166858_ChIP-Seq_MCF-7_Human1.36426466
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32508950
73BCL6_27268052_Chip-Seq_Bcells_Human1.32477204
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.32426220
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31484529
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.31308458
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30547498
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26211168
79CTCF_27219007_Chip-Seq_Bcells_Human1.26182715
80IRF1_19129219_ChIP-ChIP_H3396_Human1.19306725
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18769963
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18507414
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18503890
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16471680
85BCOR_27268052_Chip-Seq_Bcells_Human1.15924540
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15670171
87* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14645333
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14018058
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13816027
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13655920
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13611253
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13595383
93TTF2_22483619_ChIP-Seq_HELA_Human1.12838531
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12710719
95PHF8_20622854_ChIP-Seq_HELA_Human1.11395484
96SA1_27219007_Chip-Seq_Bcells_Human1.10946978
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10922122
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10731010
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.09632959
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.09599637
101STAT1_20625510_ChIP-Seq_HELA_Human1.09331641
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08673708
103P300_19829295_ChIP-Seq_ESCs_Human1.08418662
104* CTCF_21964334_Chip-Seq_Bcells_Human1.08410785
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.07108730
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06281145
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06020737
108FUS_26573619_Chip-Seq_HEK293_Human1.05772967
109* REST_21632747_ChIP-Seq_MESCs_Mouse1.05456104
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05063818
111FOXP3_21729870_ChIP-Seq_TREG_Human1.04683352
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03801571
113E2F1_20622854_ChIP-Seq_HELA_Human1.03688229
114* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03643437
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03398066
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02904499
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02417754
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02265488
119ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02012264
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.01049164
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99533674
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.99109798
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98725267
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98583238
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97787862
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97482940
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97231534
128RACK7_27058665_Chip-Seq_MCF-7_Human0.96591274
129HTT_18923047_ChIP-ChIP_STHdh_Human0.96317535
130RNF2_27304074_Chip-Seq_NSC_Mouse0.96156159
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95428298
132P300_27268052_Chip-Seq_Bcells_Human0.95312569
133EOMES_21245162_ChIP-Seq_HESCs_Human0.94957873
134* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94337742
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94085415
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94051432
137VDR_21846776_ChIP-Seq_THP-1_Human0.93607797
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93078092
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92587114
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.92178444
141* SOX2_21211035_ChIP-Seq_LN229_Human0.91874709
142* RXR_22158963_ChIP-Seq_LIVER_Mouse0.91480245
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91386404
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91350948
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.91043129
146GATA3_21867929_ChIP-Seq_CD8_Mouse0.90797783
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89939404
148NANOG_19829295_ChIP-Seq_ESCs_Human0.89426721
149SOX2_19829295_ChIP-Seq_ESCs_Human0.89426721
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88979635
151VDR_23849224_ChIP-Seq_CD4+_Human0.88928218
152IGF1R_20145208_ChIP-Seq_DFB_Human0.88810787
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87433868
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87152959
155ELK1_19687146_ChIP-ChIP_HELA_Human0.86542651
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83822490
157NANOG_20526341_ChIP-Seq_ESCs_Human0.83165647
158DCP1A_22483619_ChIP-Seq_HELA_Human0.81490479
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81087398
160CTCF_20526341_ChIP-Seq_ESCs_Human0.80487920
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.79402007
162CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77343943
163* PRDM14_20953172_ChIP-Seq_ESCs_Human0.77283893
164CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77151150
165SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76822533
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75771918
167ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.75614135
168CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.74354143
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73991635
170AR_21572438_ChIP-Seq_LNCaP_Human0.73645159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.24689142
2MP0003880_abnormal_central_pattern4.19328326
3MP0001529_abnormal_vocalization3.94840710
4MP0005670_abnormal_white_adipose3.78185316
5MP0000920_abnormal_myelination3.55892025
6MP0001905_abnormal_dopamine_level3.42775935
7MP0002139_abnormal_hepatobiliary_system2.78047550
8MP0004270_analgesia2.56187220
9MP0004142_abnormal_muscle_tone2.53771150
10MP0009379_abnormal_foot_pigmentation2.49559586
11MP0002272_abnormal_nervous_system2.49539110
12MP0003011_delayed_dark_adaptation2.43374857
13MP0002736_abnormal_nociception_after2.24573001
14MP0002064_seizures2.22048192
15MP0004742_abnormal_vestibular_system2.19163644
16MP0001968_abnormal_touch/_nociception2.17719696
17MP0006276_abnormal_autonomic_nervous2.16645125
18MP0009745_abnormal_behavioral_response2.03838398
19MP0002734_abnormal_mechanical_nocicepti2.02976568
20MP0001486_abnormal_startle_reflex1.90703534
21MP0004147_increased_porphyrin_level1.87985494
22MP0002735_abnormal_chemical_nociception1.84333397
23MP0009840_abnormal_foam_cell1.84310116
24MP0005409_darkened_coat_color1.82728193
25MP0005171_absent_coat_pigmentation1.80739006
26MP0003136_yellow_coat_color1.75872529
27MP0003315_abnormal_perineum_morphology1.73821060
28MP0003635_abnormal_synaptic_transmissio1.73605098
29MP0009046_muscle_twitch1.72428100
30MP0001970_abnormal_pain_threshold1.71965849
31MP0005423_abnormal_somatic_nervous1.70494498
32MP0000750_abnormal_muscle_regeneration1.70161479
33MP0001485_abnormal_pinna_reflex1.69541780
34MP0001986_abnormal_taste_sensitivity1.67602611
35MP0004130_abnormal_muscle_cell1.67519764
36MP0002572_abnormal_emotion/affect_behav1.67232994
37MP0000751_myopathy1.66825924
38MP0003329_amyloid_beta_deposits1.65436187
39MP0003950_abnormal_plasma_membrane1.59100968
40MP0000516_abnormal_urinary_system1.58987026
41MP0005367_renal/urinary_system_phenotyp1.58987026
42MP0005451_abnormal_body_composition1.58368951
43MP0004859_abnormal_synaptic_plasticity1.55490898
44MP0000778_abnormal_nervous_system1.54080708
45MP0002733_abnormal_thermal_nociception1.53854311
46MP0001440_abnormal_grooming_behavior1.53529954
47MP0003634_abnormal_glial_cell1.53481621
48MP0002638_abnormal_pupillary_reflex1.44625092
49MP0002067_abnormal_sensory_capabilities1.44456303
50MP0000747_muscle_weakness1.44259789
51MP0001661_extended_life_span1.44193131
52MP0008260_abnormal_autophagy1.42790294
53MP0005058_abnormal_lysosome_morphology1.42671007
54MP0000372_irregular_coat_pigmentation1.41909965
55MP0002063_abnormal_learning/memory/cond1.38597661
56MP0005645_abnormal_hypothalamus_physiol1.38429279
57MP0003879_abnormal_hair_cell1.38157646
58MP0002229_neurodegeneration1.37444313
59MP0003690_abnormal_glial_cell1.36535545
60MP0002822_catalepsy1.34715500
61MP0005084_abnormal_gallbladder_morpholo1.32287984
62MP0004043_abnormal_pH_regulation1.31564808
63MP0005330_cardiomyopathy1.28823243
64MP0006036_abnormal_mitochondrial_physio1.28689307
65MP0004381_abnormal_hair_follicle1.26778406
66MP0005332_abnormal_amino_acid1.24836495
67MP0002138_abnormal_hepatobiliary_system1.24521674
68MP0001764_abnormal_homeostasis1.20220014
69MP0002163_abnormal_gland_morphology1.20072526
70MP0000003_abnormal_adipose_tissue1.19888719
71MP0004924_abnormal_behavior1.19806082
72MP0005386_behavior/neurological_phenoty1.19806082
73MP0002938_white_spotting1.18077467
74MP0002837_dystrophic_cardiac_calcinosis1.17392322
75MP0010386_abnormal_urinary_bladder1.16663698
76MP0002971_abnormal_brown_adipose1.16351651
77MP0000049_abnormal_middle_ear1.15316695
78MP0002148_abnormal_hypersensitivity_rea1.13469496
79MP0004885_abnormal_endolymph1.13285572
80MP0001963_abnormal_hearing_physiology1.12825396
81MP0002160_abnormal_reproductive_system1.12729636
82MP0008875_abnormal_xenobiotic_pharmacok1.12531896
83MP0005410_abnormal_fertilization1.11853535
84MP0003656_abnormal_erythrocyte_physiolo1.11734633
85MP0000749_muscle_degeneration1.11641755
86MP0002066_abnormal_motor_capabilities/c1.11201962
87MP0005551_abnormal_eye_electrophysiolog1.11139126
88MP0004185_abnormal_adipocyte_glucose1.11133114
89MP0002882_abnormal_neuron_morphology1.10480336
90MP0005379_endocrine/exocrine_gland_phen1.10202878
91MP0003646_muscle_fatigue1.09736891
92MP0003806_abnormal_nucleotide_metabolis1.09340497
93MP0001849_ear_inflammation1.06402968
94MP0000955_abnormal_spinal_cord1.06283236
95MP0004510_myositis1.03845709
96MP0004145_abnormal_muscle_electrophysio1.01927610
97MP0002102_abnormal_ear_morphology1.01416026
98MP0001984_abnormal_olfaction1.01137561
99MP0010030_abnormal_orbit_morphology1.01127977
100MP0003724_increased_susceptibility_to1.00956993
101MP0002752_abnormal_somatic_nervous1.00777769
102MP0003186_abnormal_redox_activity1.00689294
103MP0004134_abnormal_chest_morphology1.00240794
104MP0005365_abnormal_bile_salt0.99909607
105MP0001188_hyperpigmentation0.99173759
106MP0009384_cardiac_valve_regurgitation0.98687356
107MP0003137_abnormal_impulse_conducting0.98666842
108MP0002184_abnormal_innervation0.97152045
109MP0005408_hypopigmentation0.96445572
110MP0008569_lethality_at_weaning0.96054941
111MP0005636_abnormal_mineral_homeostasis0.94836411
112MP0002972_abnormal_cardiac_muscle0.94672027
113MP0001501_abnormal_sleep_pattern0.94597537
114MP0003631_nervous_system_phenotype0.94406593
115MP0002557_abnormal_social/conspecific_i0.94035868
116MP0000026_abnormal_inner_ear0.93162407
117MP0002132_abnormal_respiratory_system0.91994019
118MP0002876_abnormal_thyroid_physiology0.91837886
119MP0001756_abnormal_urination0.91480139
120MP0009053_abnormal_anal_canal0.91284633
121MP0003122_maternal_imprinting0.91224916
122MP0000343_altered_response_to0.90693447
123MP0003632_abnormal_nervous_system0.90502163
124MP0005620_abnormal_muscle_contractility0.89083522
125MP0003638_abnormal_response/metabolism_0.86029371
126MP0005584_abnormal_enzyme/coenzyme_acti0.85793889
127MP0005666_abnormal_adipose_tissue0.85308952
128MP0004215_abnormal_myocardial_fiber0.85264665
129MP0003633_abnormal_nervous_system0.85215325
130MP0002295_abnormal_pulmonary_circulatio0.83697614
131MP0009780_abnormal_chondrocyte_physiolo0.83520882
132MP0005535_abnormal_body_temperature0.82025510
133MP0002751_abnormal_autonomic_nervous0.81980713
134MP0005646_abnormal_pituitary_gland0.81142308
135MP0000759_abnormal_skeletal_muscle0.81037360
136MP0005253_abnormal_eye_physiology0.81014694
137MP0006072_abnormal_retinal_apoptosis0.80910880
138MP0004019_abnormal_vitamin_homeostasis0.80057608
139MP0001727_abnormal_embryo_implantation0.79827116
140MP0006035_abnormal_mitochondrial_morpho0.79461669
141MP0002909_abnormal_adrenal_gland0.79343703
142MP0003172_abnormal_lysosome_physiology0.78202857
143MP0001664_abnormal_digestion0.76913327
144MP0000013_abnormal_adipose_tissue0.76269458
145MP0009643_abnormal_urine_homeostasis0.74527536
146MP0009785_altered_susceptibility_to0.73873301
147MP0005083_abnormal_biliary_tract0.73002329
148MP0004087_abnormal_muscle_fiber0.72331026
149MP0002106_abnormal_muscle_physiology0.72265223
150MP0005375_adipose_tissue_phenotype0.71289135
151MP0008872_abnormal_physiological_respon0.70637607
152MP0004133_heterotaxia0.70034438
153MP0004036_abnormal_muscle_relaxation0.69813412
154MP0005075_abnormal_melanosome_morpholog0.69655361
155MP0001502_abnormal_circadian_rhythm0.69637074
156MP0000604_amyloidosis0.64687658
157MP0006082_CNS_inflammation0.64655853

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.08033346
2Abnormal mitochondria in muscle tissue (HP:0008316)5.37690327
3Mitochondrial inheritance (HP:0001427)5.32983480
4Progressive macrocephaly (HP:0004481)5.13203896
5Acute encephalopathy (HP:0006846)4.81543180
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.79462810
7Renal Fanconi syndrome (HP:0001994)4.56279354
8Hepatocellular necrosis (HP:0001404)4.37330201
9Increased hepatocellular lipid droplets (HP:0006565)4.32824443
10Increased CSF lactate (HP:0002490)4.24312730
11Increased serum pyruvate (HP:0003542)4.11058494
12Abnormality of glycolysis (HP:0004366)4.11058494
13Leukodystrophy (HP:0002415)3.98707074
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.90855807
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.90855807
16Parakeratosis (HP:0001036)3.87475800
173-Methylglutaconic aciduria (HP:0003535)3.80131844
18Lipid accumulation in hepatocytes (HP:0006561)3.72040997
19Hepatic necrosis (HP:0002605)3.57104591
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41976333
21Neurofibrillary tangles (HP:0002185)3.30815851
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27448255
23Congenital ichthyosiform erythroderma (HP:0007431)3.26808117
24Optic disc pallor (HP:0000543)3.22947636
25Cerebral hypomyelination (HP:0006808)3.21972113
26Respiratory failure (HP:0002878)3.13707372
27Increased intramyocellular lipid droplets (HP:0012240)3.13130806
28Sensory axonal neuropathy (HP:0003390)3.09019803
29Cerebral edema (HP:0002181)3.06845500
30Stenosis of the external auditory canal (HP:0000402)3.06732526
31Myokymia (HP:0002411)3.00011741
32Oligomenorrhea (HP:0000876)2.94219349
33Exertional dyspnea (HP:0002875)2.93859911
34Neuroendocrine neoplasm (HP:0100634)2.93742044
35Exercise intolerance (HP:0003546)2.90621121
36Short 1st metacarpal (HP:0010034)2.88405671
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.88405671
38Abnormality of renal resorption (HP:0011038)2.86499407
39Pheochromocytoma (HP:0002666)2.81932853
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77607437
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77607437
42Lactic acidosis (HP:0003128)2.68073636
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67735804
44Reticulocytopenia (HP:0001896)2.61281281
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55938548
46Dicarboxylic aciduria (HP:0003215)2.55938548
47Abnormality of the corticospinal tract (HP:0002492)2.53870885
48Abnormality of cells of the erythroid lineage (HP:0012130)2.51153566
49Hypothermia (HP:0002045)2.51037322
50Abnormality of the 1st metacarpal (HP:0010009)2.50218110
51Increased muscle lipid content (HP:0009058)2.50092901
52Peripheral hypomyelination (HP:0007182)2.49497364
53Increased serum lactate (HP:0002151)2.47049034
54Lethargy (HP:0001254)2.41712819
55Retinal dysplasia (HP:0007973)2.39638339
56Cerebral hemorrhage (HP:0001342)2.31490000
57Generalized aminoaciduria (HP:0002909)2.31232717
58Decreased subcutaneous fat (HP:0001002)2.29800643
59Abnormal hair whorl (HP:0010721)2.29750061
60Limb dystonia (HP:0002451)2.25480500
61X-linked dominant inheritance (HP:0001423)2.24061484
62Abnormal number of erythroid precursors (HP:0012131)2.19940511
63Muscle fiber inclusion bodies (HP:0100299)2.17550283
64Short phalanx of the thumb (HP:0009660)2.15256272
65Opisthotonus (HP:0002179)2.14407446
66Metabolic acidosis (HP:0001942)2.12826635
67Myoglobinuria (HP:0002913)2.12441170
68Respiratory difficulties (HP:0002880)2.12261358
69Nemaline bodies (HP:0003798)2.12049336
70Carpal bone hypoplasia (HP:0001498)2.11787575
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07811755
72Cerebral inclusion bodies (HP:0100314)2.06162102
73Rhabdomyolysis (HP:0003201)2.04968425
74Aplasia/Hypoplasia involving the musculature (HP:0001460)2.03964277
75Hypomagnesemia (HP:0002917)2.02714238
76Myopathic facies (HP:0002058)2.00924489
77Absent thumb (HP:0009777)1.98319887
78Insulin-resistant diabetes mellitus (HP:0000831)1.97354773
79Abnormality of reticulocytes (HP:0004312)1.97278975
80Abnormality of magnesium homeostasis (HP:0004921)1.96498777
81Abnormality of fatty-acid metabolism (HP:0004359)1.95047485
82Severe muscular hypotonia (HP:0006829)1.94038534
83Methylmalonic acidemia (HP:0002912)1.91108621
84Supranuclear gaze palsy (HP:0000605)1.91071430
85CNS hypomyelination (HP:0003429)1.90832450
86Abnormality of urine glucose concentration (HP:0011016)1.90802997
87Glycosuria (HP:0003076)1.90802997
88Patchy hypopigmentation of hair (HP:0011365)1.90195654
89Hepatosplenomegaly (HP:0001433)1.88621395
90Focal motor seizures (HP:0011153)1.87504081
91Spastic paraparesis (HP:0002313)1.86997729
92Medial flaring of the eyebrow (HP:0010747)1.86788422
93Hyperphosphaturia (HP:0003109)1.86439825
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85313690
95Autoamputation (HP:0001218)1.85087799
96Exercise-induced myalgia (HP:0003738)1.84311323
97Vomiting (HP:0002013)1.83950512
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.83025153
99Muscle hypertrophy of the lower extremities (HP:0008968)1.82350022
100Macrocytic anemia (HP:0001972)1.81662993
101Distal lower limb muscle weakness (HP:0009053)1.81011564
102Abnormality of glycolipid metabolism (HP:0010969)1.80061084
103Abnormality of liposaccharide metabolism (HP:0010968)1.80061084
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.80061084
105Vaginal atresia (HP:0000148)1.79347889
106CNS demyelination (HP:0007305)1.79327282
107Ragged-red muscle fibers (HP:0003200)1.77768855
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77620044
109EMG: myopathic abnormalities (HP:0003458)1.77508782
110Spastic gait (HP:0002064)1.77165525
111Renal tubular dysfunction (HP:0000124)1.76576069
112Abnormal pupillary function (HP:0007686)1.75649491
113Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74714022
114Genital tract atresia (HP:0001827)1.74513195
115Stridor (HP:0010307)1.73681620
116Emotional lability (HP:0000712)1.72846902
117Testicular atrophy (HP:0000029)1.72374928
118Poor suck (HP:0002033)1.72156084
119Type I transferrin isoform profile (HP:0003642)1.72033956
120Abnormality of subcutaneous fat tissue (HP:0001001)1.71881469
121Calf muscle hypertrophy (HP:0008981)1.69723794
122Methylmalonic aciduria (HP:0012120)1.69190830
123Neoplasm of head and neck (HP:0012288)1.68253531
124Esophageal neoplasm (HP:0100751)1.68253531
125Axonal loss (HP:0003447)1.67751376
126Reticulocytosis (HP:0001923)1.66962093
127Reduced subcutaneous adipose tissue (HP:0003758)1.66939265
128Erythroderma (HP:0001019)1.66637853
129Oral leukoplakia (HP:0002745)1.66585645
130Delusions (HP:0000746)1.65082325
131Abnormal ciliary motility (HP:0012262)1.64998490
132White forelock (HP:0002211)1.64927183
133Abnormal urine phosphate concentration (HP:0012599)1.64365923
134Hyperuricemia (HP:0002149)1.64007214
135Increased purine levels (HP:0004368)1.64007214
136Exercise-induced muscle cramps (HP:0003710)1.63319432
137Osteomalacia (HP:0002749)1.62012934
138Muscle fiber splitting (HP:0003555)1.61919295
139Anxiety (HP:0000739)1.61826579
140Gait imbalance (HP:0002141)1.61791729
141Amniotic constriction ring (HP:0009775)1.60831590
142Abnormality of placental membranes (HP:0011409)1.60831590
143Fused cervical vertebrae (HP:0002949)1.60550889
144Late onset (HP:0003584)1.60250267
145Poor speech (HP:0002465)1.59775727
146Esotropia (HP:0000565)1.59271133
147Microvesicular hepatic steatosis (HP:0001414)1.58558579
148Purpura (HP:0000979)1.56327541
149Postnatal microcephaly (HP:0005484)1.55889214
150Blindness (HP:0000618)1.55609552
151Increased circulating renin level (HP:0000848)1.54815274
152Paralysis (HP:0003470)1.54116628
153Polyphagia (HP:0002591)1.52583613
154Progressive inability to walk (HP:0002505)1.52403716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.01314695
2VRK24.00631082
3OXSR13.32764467
4ARAF2.92961870
5BCR2.67430408
6PBK2.57808960
7STK162.53400544
8CDK192.47975782
9CASK2.44691861
10LIMK12.41730217
11MAP3K112.39150695
12MAP3K122.32475569
13MST42.09886038
14MAPKAPK52.06259352
15TNIK2.04226058
16CSNK1G31.84493072
17NME11.83363378
18UHMK11.83120950
19WNK41.78992171
20MUSK1.63207909
21PKN11.60935999
22PINK11.59639902
23MAPKAPK31.57966899
24BMPR1B1.55295698
25GRK71.54780624
26MYLK1.54364491
27TESK21.53112179
28PIM21.49922743
29EPHB11.48049874
30VRK11.39319656
31ADRBK21.37283717
32DYRK21.36482812
33CAMK2B1.33094930
34CSNK1A1L1.26756900
35NME21.26589867
36PAK61.25448765
37AURKA1.24268153
38BUB11.23148505
39BRAF1.22917715
40CSNK1G11.21591535
41CSNK1G21.16226107
42GRK51.15297480
43TAOK11.10447301
44ROCK21.09654514
45MAPK131.08147016
46TRIB31.06399005
47CLK11.05402329
48CAMK2D0.99832746
49TAOK20.99502088
50PRKD30.98592017
51EIF2AK30.96120943
52MAP2K70.95107603
53BMPR20.93746849
54DAPK10.92995924
55MAP4K20.92921944
56CAMK2G0.92716359
57IRAK40.91612526
58NEK60.90183756
59MAP2K30.87930182
60TLK10.87404228
61CDK90.87169143
62PRKD20.86232108
63PRPF4B0.85582934
64OBSCN0.85516819
65FGR0.84909503
66PRKCI0.83843025
67EPHB20.83261382
68MAPK120.80329259
69CAMK2A0.80000604
70EPHA40.79108841
71MARK10.79003585
72NTRK10.78983083
73DYRK30.78211761
74MAP2K10.77661145
75MAP2K60.77480142
76MAPK150.77131987
77CDK140.76767686
78CCNB10.76165631
79DAPK20.75947156
80FES0.75728043
81ERN10.75710564
82PRKCE0.74978176
83ILK0.74277987
84WNK10.71621758
85IRAK20.69778430
86SGK4940.69352019
87SGK2230.69352019
88DAPK30.68067163
89PRKCQ0.67845610
90RPS6KA50.67759631
91CDK180.67363461
92CAMK10.65920603
93MAP2K40.65882393
94PNCK0.65879386
95CDK150.64282939
96CDK11A0.63616464
97BLK0.62689158
98MET0.62196019
99CDK50.61664648
100ZAK0.61650692
101MAP3K30.60467648
102WNK30.58781966
103CAMKK10.58550579
104ADRBK10.58315818
105PRKD10.57561204
106PDK20.54051128
107PLK20.53806015
108MAP2K20.53628955
109BRSK10.53579875
110TBK10.53507431
111ABL20.53278409
112LMTK20.52147270
113TESK10.51222768
114KDR0.48089749
115NTRK30.47698295
116CAMKK20.47504847
117PAK10.46821357
118SYK0.46294436
119GRK10.45456855
120PRKACA0.44239623
121TNK20.43582209
122IRAK30.43284530
123MINK10.41023550
124MKNK10.40297280
125CSNK2A10.40178742
126EPHA20.39939618
127PHKG20.39272526
128PHKG10.39272526
129TIE10.38668414
130SIK10.38204607
131PRKG20.38109395
132LRRK20.38042630
133INSRR0.37745611
134AKT20.37721776
135PAK40.37048449
136DYRK1B0.36262669
137MAPK40.36043289
138CSNK1A10.35885852
139PRKG10.34129428
140SIK30.33789123
141BCKDK0.33522808
142PTK2B0.32693520
143IKBKB0.32018154
144PAK30.31834078
145RAF10.30092449
146NTRK20.29141612
147PRKCD0.28758380
148PRKCG0.28547338
149FYN0.28509788
150TXK0.28186010

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.66292020
2Parkinsons disease_Homo sapiens_hsa050124.70881468
3Alzheimers disease_Homo sapiens_hsa050103.67046477
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.57094848
5Protein export_Homo sapiens_hsa030603.38874148
6Ribosome_Homo sapiens_hsa030103.22085941
7Huntingtons disease_Homo sapiens_hsa050163.14673326
8Fatty acid elongation_Homo sapiens_hsa000623.02228048
9Proteasome_Homo sapiens_hsa030503.01539446
10Sulfur relay system_Homo sapiens_hsa041222.90787238
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.83871449
12Collecting duct acid secretion_Homo sapiens_hsa049662.40577249
13Steroid biosynthesis_Homo sapiens_hsa001002.32302338
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32094432
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15942100
16Cardiac muscle contraction_Homo sapiens_hsa042602.05583708
17RNA polymerase_Homo sapiens_hsa030201.93600164
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88259782
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77804678
20Vibrio cholerae infection_Homo sapiens_hsa051101.77510793
21Ether lipid metabolism_Homo sapiens_hsa005651.71333799
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60040787
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59944491
24Sulfur metabolism_Homo sapiens_hsa009201.38801151
25Rheumatoid arthritis_Homo sapiens_hsa053231.34692846
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26890779
27Synaptic vesicle cycle_Homo sapiens_hsa047211.23148305
28Serotonergic synapse_Homo sapiens_hsa047261.17523790
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13267831
30Carbon metabolism_Homo sapiens_hsa012001.12400839
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10736744
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09944317
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05875978
34beta-Alanine metabolism_Homo sapiens_hsa004101.05774439
35Phagosome_Homo sapiens_hsa041451.05711277
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.04794384
37Galactose metabolism_Homo sapiens_hsa000521.01362759
38Fatty acid degradation_Homo sapiens_hsa000711.01057860
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.99579147
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98419889
41Fructose and mannose metabolism_Homo sapiens_hsa000510.98121920
42Sphingolipid metabolism_Homo sapiens_hsa006000.97314295
43Tryptophan metabolism_Homo sapiens_hsa003800.96014601
44Arachidonic acid metabolism_Homo sapiens_hsa005900.95097912
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.93093320
46PPAR signaling pathway_Homo sapiens_hsa033200.93026540
47Histidine metabolism_Homo sapiens_hsa003400.88748287
48Glutathione metabolism_Homo sapiens_hsa004800.88582993
49Linoleic acid metabolism_Homo sapiens_hsa005910.87852941
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87360967
51GABAergic synapse_Homo sapiens_hsa047270.87336927
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87148282
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86224786
54Nicotine addiction_Homo sapiens_hsa050330.85387950
55Fatty acid metabolism_Homo sapiens_hsa012120.82178085
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81489065
57Phototransduction_Homo sapiens_hsa047440.81403241
58Renin-angiotensin system_Homo sapiens_hsa046140.80881307
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76967444
60Pentose phosphate pathway_Homo sapiens_hsa000300.75526596
61Morphine addiction_Homo sapiens_hsa050320.74481016
62Metabolic pathways_Homo sapiens_hsa011000.72637060
63Biosynthesis of amino acids_Homo sapiens_hsa012300.72416097
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72097487
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70233311
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69960845
67Glutamatergic synapse_Homo sapiens_hsa047240.68115767
68Systemic lupus erythematosus_Homo sapiens_hsa053220.67677656
69Autoimmune thyroid disease_Homo sapiens_hsa053200.64659553
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64466109
71Pyrimidine metabolism_Homo sapiens_hsa002400.63700181
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63403807
73Vitamin B6 metabolism_Homo sapiens_hsa007500.62311402
74Axon guidance_Homo sapiens_hsa043600.62191829
75Arginine biosynthesis_Homo sapiens_hsa002200.61535686
76Cocaine addiction_Homo sapiens_hsa050300.61378407
77Regulation of autophagy_Homo sapiens_hsa041400.60791390
78Basal transcription factors_Homo sapiens_hsa030220.58195910
79Arginine and proline metabolism_Homo sapiens_hsa003300.55833705
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55259335
81Purine metabolism_Homo sapiens_hsa002300.54534498
82Asthma_Homo sapiens_hsa053100.53893182
83Long-term depression_Homo sapiens_hsa047300.53859128
84Butanoate metabolism_Homo sapiens_hsa006500.53481195
85Dopaminergic synapse_Homo sapiens_hsa047280.52111208
86Taste transduction_Homo sapiens_hsa047420.51945841
87Circadian entrainment_Homo sapiens_hsa047130.50878623
88Graft-versus-host disease_Homo sapiens_hsa053320.50428481
89Retinol metabolism_Homo sapiens_hsa008300.50266039
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50164382
91Base excision repair_Homo sapiens_hsa034100.49868793
92Allograft rejection_Homo sapiens_hsa053300.48500898
93Insulin secretion_Homo sapiens_hsa049110.45303829
94Tyrosine metabolism_Homo sapiens_hsa003500.45241271
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44982516
96Mineral absorption_Homo sapiens_hsa049780.44760510
97Pyruvate metabolism_Homo sapiens_hsa006200.44693212
98Homologous recombination_Homo sapiens_hsa034400.44454532
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44253837
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.44083563
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43447603
102Alcoholism_Homo sapiens_hsa050340.42656577
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42473784
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.40848545
105Cholinergic synapse_Homo sapiens_hsa047250.40395966
106Lysosome_Homo sapiens_hsa041420.38350484
107Amphetamine addiction_Homo sapiens_hsa050310.36769984
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.35803251
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.34279288
110Glycerolipid metabolism_Homo sapiens_hsa005610.33526638
111Olfactory transduction_Homo sapiens_hsa047400.32886223
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.31033464
113Folate biosynthesis_Homo sapiens_hsa007900.29832836
114Fat digestion and absorption_Homo sapiens_hsa049750.29563491
115Peroxisome_Homo sapiens_hsa041460.28907011
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.28409286
117Dilated cardiomyopathy_Homo sapiens_hsa054140.28101862
118DNA replication_Homo sapiens_hsa030300.27210348
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27028393
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26088322
121Nucleotide excision repair_Homo sapiens_hsa034200.25906844
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24072012
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23979567
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23580304
125Pertussis_Homo sapiens_hsa051330.23029418
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20456883
127Phenylalanine metabolism_Homo sapiens_hsa003600.19786552
128Malaria_Homo sapiens_hsa051440.19599250
129Salivary secretion_Homo sapiens_hsa049700.18203148
130Ras signaling pathway_Homo sapiens_hsa040140.18052659
131Starch and sucrose metabolism_Homo sapiens_hsa005000.17866478
132Calcium signaling pathway_Homo sapiens_hsa040200.15854393
133Salmonella infection_Homo sapiens_hsa051320.15493312
134Spliceosome_Homo sapiens_hsa030400.14216998
135Chemical carcinogenesis_Homo sapiens_hsa052040.14194274
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13794918
137Type I diabetes mellitus_Homo sapiens_hsa049400.13505520
138Propanoate metabolism_Homo sapiens_hsa006400.13118385
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12294101
140Other glycan degradation_Homo sapiens_hsa005110.11701266
141Hematopoietic cell lineage_Homo sapiens_hsa046400.09114270
142Gastric acid secretion_Homo sapiens_hsa049710.07906095
143Endocytosis_Homo sapiens_hsa041440.06883793
144Gap junction_Homo sapiens_hsa045400.06301091

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