FHOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)4.95713511
2apoptotic cell clearance (GO:0043277)4.58306873
3response to peptidoglycan (GO:0032494)4.30473228
4immunoglobulin mediated immune response (GO:0016064)4.18829686
5T cell apoptotic process (GO:0070231)4.14664344
6positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.10766799
7negative regulation of T-helper cell differentiation (GO:0045623)4.01580786
8negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.01580786
9regulation of B cell apoptotic process (GO:0002902)3.63907250
10B cell mediated immunity (GO:0019724)3.62988584
11NLS-bearing protein import into nucleus (GO:0006607)3.50726659
12positive regulation of gamma-delta T cell activation (GO:0046645)3.46801877
13lymphocyte apoptotic process (GO:0070227)3.45767473
14regulation of mitotic spindle organization (GO:0060236)3.43733549
15negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41007649
16regulation of cholesterol storage (GO:0010885)3.40115280
17germinal center formation (GO:0002467)3.27412247
18positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.27409328
19endothelial tube morphogenesis (GO:0061154)3.20163386
20morphogenesis of an endothelium (GO:0003159)3.20163386
21response to muramyl dipeptide (GO:0032495)3.19676276
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19408052
23regulation of gamma-delta T cell differentiation (GO:0045586)3.13175749
24muscle filament sliding (GO:0030049)3.12632503
25actin-myosin filament sliding (GO:0033275)3.12632503
26barbed-end actin filament capping (GO:0051016)3.12237843
27protein localization to endosome (GO:0036010)3.10146984
28positive regulation of triglyceride biosynthetic process (GO:0010867)3.07176710
29neutrophil activation involved in immune response (GO:0002283)3.05848003
30stress fiber assembly (GO:0043149)3.05775851
31skeletal muscle contraction (GO:0003009)3.04547093
32negative regulation of stress fiber assembly (GO:0051497)3.00475721
33positive regulation of cholesterol efflux (GO:0010875)2.99958940
34negative regulation of cell size (GO:0045792)2.95562591
35regulation of T-helper 2 cell differentiation (GO:0045628)2.94348866
36regulation of cholesterol homeostasis (GO:2000188)2.93070404
37lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93018053
38sarcoplasmic reticulum calcium ion transport (GO:0070296)2.92112262
39regulation of gamma-delta T cell activation (GO:0046643)2.90525617
40cellular extravasation (GO:0045123)2.88612772
41regulation of interferon-beta biosynthetic process (GO:0045357)2.86936211
42positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85554298
43respiratory tube development (GO:0030323)2.84738739
44focal adhesion assembly (GO:0048041)2.84069790
45cell-substrate adherens junction assembly (GO:0007045)2.84069790
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81680345
47negative regulation of cell killing (GO:0031342)2.81680345
48regulation of interleukin-8 biosynthetic process (GO:0045414)2.81392403
49negative regulation of alpha-beta T cell differentiation (GO:0046639)2.79997006
50cellular response to thyroid hormone stimulus (GO:0097067)2.79925901
51NIK/NF-kappaB signaling (GO:0038061)2.78860674
52regulation of mast cell degranulation (GO:0043304)2.78249148
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77903218
54negative regulation of granulocyte differentiation (GO:0030853)2.77498689
55lung vasculature development (GO:0060426)2.77449783
56macrophage activation involved in immune response (GO:0002281)2.76695471
57regulation of leukocyte degranulation (GO:0043300)2.74320655
58modulation by symbiont of host cellular process (GO:0044068)2.69838024
59pentose-phosphate shunt (GO:0006098)2.66039063
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65706858
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65599720
62positive regulation by organism of defense response of other organism involved in symbiotic interact2.65599720
63modulation by symbiont of host immune response (GO:0052553)2.65599720
64positive regulation by symbiont of host defense response (GO:0052509)2.65599720
65modulation by symbiont of host defense response (GO:0052031)2.65599720
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65599720
67positive regulation of histone deacetylation (GO:0031065)2.64807675
68positive regulation of sterol transport (GO:0032373)2.64676302
69positive regulation of cholesterol transport (GO:0032376)2.64676302
70regulation of early endosome to late endosome transport (GO:2000641)2.64472566
71regulation of skeletal muscle contraction (GO:0014819)2.61936966
72regulation of histone H3-K27 methylation (GO:0061085)2.60476520
73leukocyte apoptotic process (GO:0071887)2.59510092
74negative regulation of type 2 immune response (GO:0002829)2.58580058
75positive regulation of myotube differentiation (GO:0010831)2.58524819
76response to laminar fluid shear stress (GO:0034616)2.57525213
77substrate-dependent cell migration (GO:0006929)2.56735223
78negative regulation of necroptotic process (GO:0060546)2.56495222
79regulation of necroptotic process (GO:0060544)2.56259249
80negative regulation of phagocytosis (GO:0050765)2.55111154
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53859715
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53859715
83negative regulation of interleukin-12 production (GO:0032695)2.53617955
84basement membrane organization (GO:0071711)2.53553241
85vascular endothelial growth factor signaling pathway (GO:0038084)2.53134623
86epithelial cell differentiation involved in prostate gland development (GO:0060742)2.52784969
87regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52365798
88positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52025833
89cell adhesion mediated by integrin (GO:0033627)2.51907414
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51721552
91negative regulation of erythrocyte differentiation (GO:0045647)2.51077503
92glycosphingolipid catabolic process (GO:0046479)2.50307937
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49695537
94negative regulation of innate immune response (GO:0045824)2.49175942
95regulation of integrin activation (GO:0033623)2.47202864
96positive regulation of B cell differentiation (GO:0045579)2.46543140
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45533361
98detection of other organism (GO:0098543)2.45086137
99response to thyroid hormone (GO:0097066)2.44637355
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44532316
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44043698
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.43954105
103positive thymic T cell selection (GO:0045059)2.43234667
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42780574
105regulation of tight junction assembly (GO:2000810)2.42649158
106modulation by virus of host process (GO:0019054)2.42065955
107regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41907112
108regulation of response to interferon-gamma (GO:0060330)2.41745680
109detection of molecule of bacterial origin (GO:0032490)2.41431410
110cell-substrate junction assembly (GO:0007044)2.41275771
111positive regulation of protein dephosphorylation (GO:0035307)2.40276626
112natural killer cell differentiation (GO:0001779)2.39529021
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.38941536
114detection of bacterium (GO:0016045)2.38888039
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.38551588
116wound healing, spreading of epidermal cells (GO:0035313)2.37999021
117negative regulation of Rho protein signal transduction (GO:0035024)2.37530104
118actin-mediated cell contraction (GO:0070252)2.36988613
119negative regulation of cytokine production involved in immune response (GO:0002719)2.36936301
120regulation of mast cell activation involved in immune response (GO:0033006)2.36605667
121antigen processing and presentation of endogenous antigen (GO:0019883)2.36576855
122regulation of interleukin-2 biosynthetic process (GO:0045076)2.35673511
123positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34216583
124regulation of macrophage cytokine production (GO:0010935)2.33480709
125apoptotic process involved in morphogenesis (GO:0060561)2.33361057
126negative regulation of lipid storage (GO:0010888)2.32860129
127regulation of interleukin-12 biosynthetic process (GO:0045075)2.31263999
128detection of external biotic stimulus (GO:0098581)2.30850723
129regulation of spindle organization (GO:0090224)2.30794103
130regulation of B cell receptor signaling pathway (GO:0050855)2.30760288
131negative regulation of B cell mediated immunity (GO:0002713)2.29861602
132negative regulation of immunoglobulin mediated immune response (GO:0002890)2.29861602
133endodermal cell differentiation (GO:0035987)2.29822335
134pinocytosis (GO:0006907)2.29666153
135regulation of G0 to G1 transition (GO:0070316)2.29116007
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.27861920
137positive regulation of receptor recycling (GO:0001921)2.27105955
138hypotonic response (GO:0006971)2.26988618
139adenosine receptor signaling pathway (GO:0001973)2.26876869
140positive regulation of triglyceride lipase activity (GO:0061365)2.26766607
141positive regulation of lipoprotein lipase activity (GO:0051006)2.26766607
142Golgi transport vesicle coating (GO:0048200)2.26554471
143COPI coating of Golgi vesicle (GO:0048205)2.26554471
144response to fluid shear stress (GO:0034405)2.26139025
145positive regulation of interferon-alpha production (GO:0032727)2.25934684
146regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.24895568
147regulation of cholesterol efflux (GO:0010874)2.24156091
148definitive hemopoiesis (GO:0060216)2.23465031
149mannose metabolic process (GO:0006013)2.22936120
150positive regulation of SMAD protein import into nucleus (GO:0060391)2.22590701
151adherens junction assembly (GO:0034333)2.22242209
152thymic T cell selection (GO:0045061)2.21342277
153NADPH regeneration (GO:0006740)2.21224784
154creatine metabolic process (GO:0006600)2.20877420
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.20116659
156actin filament-based movement (GO:0030048)2.19749521
1573-UTR-mediated mRNA stabilization (GO:0070935)2.19346055
158regulation of necrotic cell death (GO:0010939)2.18636854
159negative regulation of lymphocyte apoptotic process (GO:0070229)2.18423861
160positive regulation of natural killer cell differentiation (GO:0032825)2.18227452
161lung lobe morphogenesis (GO:0060463)2.18061935
162adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.18051611
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17858743
164response to host (GO:0075136)2.17858743
165response to host defenses (GO:0052200)2.17858743
166negative regulation of alpha-beta T cell activation (GO:0046636)2.17851760
167B cell receptor signaling pathway (GO:0050853)2.17534007
168hyaluronan catabolic process (GO:0030214)2.17497667
169mRNA stabilization (GO:0048255)2.16959953
170RNA stabilization (GO:0043489)2.16959953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.97167192
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.66922676
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50121192
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.04064038
5MYC_22102868_ChIP-Seq_BL_Human3.00851643
6VDR_21846776_ChIP-Seq_THP-1_Human2.69415041
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56453356
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.48661744
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47965139
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.32872918
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.26485874
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21891731
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14352600
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14162376
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.13489762
16TCF7_22412390_ChIP-Seq_EML_Mouse2.12983223
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02997262
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02825979
19* MAF_26560356_Chip-Seq_TH1_Human2.01715694
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01553678
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.00275496
22CLOCK_20551151_ChIP-Seq_293T_Human1.98171764
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98100518
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.94914590
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91169514
26VDR_24763502_ChIP-Seq_THP-1_Human1.86174489
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82923463
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81293246
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79028604
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76439737
31SCL_19346495_ChIP-Seq_HPC-7_Human1.74112172
32KDM2B_26808549_Chip-Seq_DND41_Human1.71029479
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70356787
34UTX_26944678_Chip-Seq_JUKART_Human1.70092928
35* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59256816
36* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58036346
37SPI1_23127762_ChIP-Seq_K562_Human1.56734817
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55205280
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54719381
40MYB_26560356_Chip-Seq_TH1_Human1.53080777
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52337222
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52139848
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51249534
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51169513
45ZNF263_19887448_ChIP-Seq_K562_Human1.48577896
46MYB_26560356_Chip-Seq_TH2_Human1.47531002
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46091598
48* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44153989
49SPI1_23547873_ChIP-Seq_NB4_Human1.43945868
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.43723313
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39664117
52* NCOR1_26117541_ChIP-Seq_K562_Human1.39524113
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38074500
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33086398
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32513460
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32437166
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31927677
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30747558
59RUNX_20019798_ChIP-Seq_JUKART_Human1.29736612
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29603321
61P68_20966046_ChIP-Seq_HELA_Human1.29017072
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28480433
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.28125516
64* KDM2B_26808549_Chip-Seq_K562_Human1.27857740
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.25598269
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24990336
67LXR_22292898_ChIP-Seq_THP-1_Human1.24332668
68GATA1_22025678_ChIP-Seq_K562_Human1.24086146
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22878297
70* MAF_26560356_Chip-Seq_TH2_Human1.21485655
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.20967033
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.18115698
73RACK7_27058665_Chip-Seq_MCF-7_Human1.17401902
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16772678
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16756505
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.16635225
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15621941
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14400849
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.13973883
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13240526
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12006961
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11848802
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11064388
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10604186
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10376833
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09681002
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09542496
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09488607
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09449741
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08694743
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08679914
92BCOR_27268052_Chip-Seq_Bcells_Human1.08669314
93ATF3_27146783_Chip-Seq_COLON_Human1.08187557
94GATA1_19941826_ChIP-Seq_K562_Human1.06933381
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06685199
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06333451
97* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06298543
98* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06298543
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06095262
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06007364
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05491503
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05200489
103* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05108253
104SMC4_20622854_ChIP-Seq_HELA_Human1.04397816
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04108292
106PU_27001747_Chip-Seq_BMDM_Mouse1.03943601
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03679383
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03496157
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02888728
110BCL6_27268052_Chip-Seq_Bcells_Human1.02829657
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02317778
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01854719
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01699364
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01679526
115TFEB_21752829_ChIP-Seq_HELA_Human1.01213528
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01143766
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00621980
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99845902
119* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99648244
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99397553
121AR_21909140_ChIP-Seq_LNCAP_Human0.99285091
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99179114
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98716540
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.98288139
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.98288139
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.97013400
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95429839
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95237775
129BRD4_25478319_ChIP-Seq_HGPS_Human0.94523551
130E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94471880
131GATA6_25053715_ChIP-Seq_YYC3_Human0.93738890
132VDR_24787735_ChIP-Seq_THP-1_Human0.93001110
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.92601817
134TP53_22127205_ChIP-Seq_IMR90_Human0.91895305
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91165312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.30859263
2MP0005451_abnormal_body_composition3.29038299
3MP0003705_abnormal_hypodermis_morpholog3.20869968
4MP0003566_abnormal_cell_adhesion2.56121887
5MP0000685_abnormal_immune_system2.33352766
6MP0010352_gastrointestinal_tract_polyps2.16202114
7MP0002139_abnormal_hepatobiliary_system2.14777677
8MP0008438_abnormal_cutaneous_collagen2.12593671
9MP0009278_abnormal_bone_marrow2.02413357
10MP0008260_abnormal_autophagy2.00618454
11MP0002877_abnormal_melanocyte_morpholog1.96165406
12MP0002396_abnormal_hematopoietic_system1.95761471
13MP0004233_abnormal_muscle_weight1.95665658
14MP0005076_abnormal_cell_differentiation1.92559267
15MP0003279_aneurysm1.89737575
16MP0010368_abnormal_lymphatic_system1.89471657
17MP0004808_abnormal_hematopoietic_stem1.87118580
18MP0004272_abnormal_basement_membrane1.86154435
19MP0009840_abnormal_foam_cell1.85395332
20MP0001849_ear_inflammation1.72962294
21MP0001835_abnormal_antigen_presentation1.72270905
22MP0001853_heart_inflammation1.68381716
23MP0000747_muscle_weakness1.67659314
24MP0004510_myositis1.66027758
25MP0001958_emphysema1.65748489
26MP0000759_abnormal_skeletal_muscle1.64764696
27MP0003303_peritoneal_inflammation1.62481096
28MP0003436_decreased_susceptibility_to1.60665653
29MP0001879_abnormal_lymphatic_vessel1.60578033
30MP0003300_gastrointestinal_ulcer1.58417200
31MP0004036_abnormal_muscle_relaxation1.58345455
32MP0005023_abnormal_wound_healing1.52863525
33MP0001790_abnormal_immune_system1.51740095
34MP0005387_immune_system_phenotype1.51740095
35MP0002166_altered_tumor_susceptibility1.48876040
36MP0003646_muscle_fatigue1.46605038
37MP0001800_abnormal_humoral_immune1.46600994
38MP0000733_abnormal_muscle_development1.43126770
39MP0002452_abnormal_antigen_presenting1.41165664
40MP0000465_gastrointestinal_hemorrhage1.39933931
41MP0003091_abnormal_cell_migration1.35359331
42MP0006054_spinal_hemorrhage1.34010865
43MP0001545_abnormal_hematopoietic_system1.32427406
44MP0005397_hematopoietic_system_phenotyp1.32427406
45MP0000767_abnormal_smooth_muscle1.30876824
46MP0005666_abnormal_adipose_tissue1.26516954
47MP0003453_abnormal_keratinocyte_physiol1.26031365
48MP0005330_cardiomyopathy1.25884244
49MP0002405_respiratory_system_inflammati1.24635144
50MP0010630_abnormal_cardiac_muscle1.24070974
51MP0002398_abnormal_bone_marrow1.22196645
52MP0005464_abnormal_platelet_physiology1.21372123
53MP0002106_abnormal_muscle_physiology1.20183677
54MP0002332_abnormal_exercise_endurance1.19894077
55MP0003828_pulmonary_edema1.19685602
56MP0002420_abnormal_adaptive_immunity1.18754628
57MP0001819_abnormal_immune_cell1.18547962
58MP0009333_abnormal_splenocyte_physiolog1.18036793
59MP0005058_abnormal_lysosome_morphology1.17878043
60MP0005375_adipose_tissue_phenotype1.17869309
61MP0002419_abnormal_innate_immunity1.16909850
62MP0005025_abnormal_response_to1.16714142
63MP0005167_abnormal_blood-brain_barrier1.16282968
64MP0006082_CNS_inflammation1.15703289
65MP0002723_abnormal_immune_serum1.13884018
66MP0002269_muscular_atrophy1.13673434
67MP0000569_abnormal_digit_pigmentation1.12076054
68MP0000689_abnormal_spleen_morphology1.11079565
69MP0004185_abnormal_adipocyte_glucose1.09877517
70MP0005275_abnormal_skin_tensile1.08901573
71MP0005623_abnormal_meninges_morphology1.08419139
72MP0001915_intracranial_hemorrhage1.07395069
73MP0004087_abnormal_muscle_fiber1.06590185
74MP0000003_abnormal_adipose_tissue1.05860494
75MP0000749_muscle_degeneration1.05668575
76MP0003724_increased_susceptibility_to1.04736342
77MP0000751_myopathy1.03778544
78MP0003656_abnormal_erythrocyte_physiolo1.02997780
79MP0002128_abnormal_blood_circulation1.02920163
80MP0002925_abnormal_cardiovascular_devel1.02479145
81MP0010030_abnormal_orbit_morphology1.02442683
82MP0000343_altered_response_to1.02089263
83MP0003075_altered_response_to1.01958160
84MP0005000_abnormal_immune_tolerance1.01596539
85MP0004084_abnormal_cardiac_muscle1.01206109
86MP0002722_abnormal_immune_system1.00529154
87MP0000490_abnormal_crypts_of1.00432649
88MP0010307_abnormal_tumor_latency1.00261381
89MP0003448_altered_tumor_morphology0.99760361
90MP0000750_abnormal_muscle_regeneration0.98491474
91MP0005671_abnormal_response_to0.98170905
92MP0000249_abnormal_blood_vessel0.98141227
93MP0000716_abnormal_immune_system0.97893683
94MP0006138_congestive_heart_failure0.97569701
95MP0004947_skin_inflammation0.97356095
96MP0002006_tumorigenesis0.96755640
97MP0002086_abnormal_extraembryonic_tissu0.96140217
98MP0010155_abnormal_intestine_physiology0.95768677
99MP0001533_abnormal_skeleton_physiology0.95277452
100MP0002429_abnormal_blood_cell0.92723781
101MP0001873_stomach_inflammation0.92607015
102MP0002088_abnormal_embryonic_growth/wei0.91217231
103MP0003984_embryonic_growth_retardation0.91102904
104MP0001614_abnormal_blood_vessel0.90729093
105MP0004197_abnormal_fetal_growth/weight/0.90680958
106MP0005369_muscle_phenotype0.90391290
107MP0000703_abnormal_thymus_morphology0.90162731
108MP0003045_fibrosis0.89697857
109MP0000858_altered_metastatic_potential0.89156547
110MP0009785_altered_susceptibility_to0.88159100
111MP0000266_abnormal_heart_morphology0.85740160
112MP0001845_abnormal_inflammatory_respons0.85709752
113MP0008469_abnormal_protein_level0.85229793
114MP0003221_abnormal_cardiomyocyte_apopto0.84514391
115MP0003172_abnormal_lysosome_physiology0.84253053
116MP0004145_abnormal_muscle_electrophysio0.82917170
117MP0005670_abnormal_white_adipose0.82607769
118MP0003115_abnormal_respiratory_system0.82544411
119MP0003806_abnormal_nucleotide_metabolis0.81272700
120MP0003567_abnormal_fetal_cardiomyocyte0.81082183
121MP0004858_abnormal_nervous_system0.80814883
122MP0004130_abnormal_muscle_cell0.80651439
123MP0003763_abnormal_thymus_physiology0.79974989
124MP0002998_abnormal_bone_remodeling0.78913797
125MP0005409_darkened_coat_color0.78243922
126MP0002933_joint_inflammation0.77731706
127MP0001661_extended_life_span0.77184008
128MP0001672_abnormal_embryogenesis/_devel0.77038603
129MP0005380_embryogenesis_phenotype0.77038603
130MP0002148_abnormal_hypersensitivity_rea0.76545385
131MP0000678_abnormal_parathyroid_gland0.76504876
132MP0002254_reproductive_system_inflammat0.75266480

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.74212158
2Muscle fiber inclusion bodies (HP:0100299)4.72998715
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.60854278
4Exercise-induced myalgia (HP:0003738)4.58254609
5Centrally nucleated skeletal muscle fibers (HP:0003687)3.90335632
6Cerebral aneurysm (HP:0004944)3.88607979
7Aortic aneurysm (HP:0004942)3.61798218
8Distal lower limb muscle weakness (HP:0009053)3.58708875
9Protrusio acetabuli (HP:0003179)3.57180980
10Myopathic facies (HP:0002058)3.55471771
11Distal lower limb amyotrophy (HP:0008944)3.48422232
12Increased connective tissue (HP:0009025)3.27088196
13Abnormality of the peritoneum (HP:0002585)3.11857715
14Autoimmune thrombocytopenia (HP:0001973)3.08373757
15Hematochezia (HP:0002573)2.99265287
16Aortic dissection (HP:0002647)2.86971264
17Abnormality of macrophages (HP:0004311)2.78939318
18Abnormality of glycolipid metabolism (HP:0010969)2.75352118
19Abnormality of liposaccharide metabolism (HP:0010968)2.75352118
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.75352118
21Round ear (HP:0100830)2.73483092
22Ankle contracture (HP:0006466)2.72132676
23Spontaneous hematomas (HP:0007420)2.69597683
24Rhabdomyolysis (HP:0003201)2.67120060
25EMG: myopathic abnormalities (HP:0003458)2.65586401
26Type 1 muscle fiber predominance (HP:0003803)2.64783645
27Shallow orbits (HP:0000586)2.63600760
28Dysostosis multiplex (HP:0000943)2.58562904
29Mediastinal lymphadenopathy (HP:0100721)2.54700354
30Recurrent abscess formation (HP:0002722)2.53874189
31Polycythemia (HP:0001901)2.50859673
32Ulnar bowing (HP:0003031)2.48310117
33Abnormality of the fingertips (HP:0001211)2.44222955
34Increased cerebral lipofuscin (HP:0011813)2.42825498
35Increased density of long bones (HP:0006392)2.41682347
36Broad metatarsal (HP:0001783)2.40382787
37Achilles tendon contracture (HP:0001771)2.39643882
38Hyperacusis (HP:0010780)2.37482150
39Mitral valve prolapse (HP:0001634)2.37343350
40Eczematoid dermatitis (HP:0000976)2.36122002
41Progressive muscle weakness (HP:0003323)2.34698812
42Camptodactyly of toe (HP:0001836)2.34549724
43Long toe (HP:0010511)2.33876080
44Aneurysm (HP:0002617)2.33047585
45Muscle stiffness (HP:0003552)2.31913608
46Osteolytic defects of the hand bones (HP:0009699)2.31383255
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.31383255
48Bulbar palsy (HP:0001283)2.31301192
49Cellulitis (HP:0100658)2.29267253
50Lower limb amyotrophy (HP:0007210)2.27991000
51Distal arthrogryposis (HP:0005684)2.27976197
52Abnormality of the nasal mucosa (HP:0000433)2.27160532
53Mildly elevated creatine phosphokinase (HP:0008180)2.23774136
54Broad face (HP:0000283)2.22997280
55Vacuolated lymphocytes (HP:0001922)2.22933008
56Axonal loss (HP:0003447)2.21877422
57Frequent falls (HP:0002359)2.20320067
58Premature rupture of membranes (HP:0001788)2.20078949
59Neck muscle weakness (HP:0000467)2.17390971
60Abnormality of skeletal muscle fiber size (HP:0012084)2.17231912
61Syringomyelia (HP:0003396)2.15789368
62Spinal cord lesions (HP:0100561)2.15789368
63Dilatation of the ascending aorta (HP:0005111)2.15363020
64Interstitial pulmonary disease (HP:0006530)2.12340612
65Myoglobinuria (HP:0002913)2.10986867
66Bicuspid aortic valve (HP:0001647)2.10667151
67Increased variability in muscle fiber diameter (HP:0003557)2.09229974
68Ragged-red muscle fibers (HP:0003200)2.07201439
69Cervical subluxation (HP:0003308)2.07103386
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06333502
71Abnormality of polysaccharide metabolism (HP:0011012)2.06333502
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06333502
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.05444491
74Abnormality of the Achilles tendon (HP:0005109)2.04440566
75Disproportionate tall stature (HP:0001519)2.04260096
76Short 4th metacarpal (HP:0010044)2.02359915
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02359915
78Spinal rigidity (HP:0003306)2.02000750
79Recurrent bacterial skin infections (HP:0005406)2.01853340
80Colitis (HP:0002583)2.01719962
81Nuclear cataract (HP:0100018)2.01514282
82Urinary glycosaminoglycan excretion (HP:0003541)2.00442948
83Mucopolysacchariduria (HP:0008155)2.00442948
84Vertebral compression fractures (HP:0002953)1.99026041
85Esophageal varix (HP:0002040)1.98331290
86Hemiplegia (HP:0002301)1.97737764
87Increased serum ferritin (HP:0003281)1.97333207
88Generalized amyotrophy (HP:0003700)1.96743670
89Loss of speech (HP:0002371)1.94789331
90Upper motor neuron abnormality (HP:0002127)1.93370104
91Slender build (HP:0001533)1.92986712
92Exercise-induced muscle cramps (HP:0003710)1.91766709
93Systemic lupus erythematosus (HP:0002725)1.91662312
94Chronic obstructive pulmonary disease (HP:0006510)1.91457099
95Obstructive lung disease (HP:0006536)1.91457099
96Easy fatigability (HP:0003388)1.90572106
97Lymphangioma (HP:0100764)1.90528779
98Recurrent viral infections (HP:0004429)1.90243029
99Stridor (HP:0010307)1.89991634
100Ulnar deviation of the wrist (HP:0003049)1.89704308
101Flexion contracture of toe (HP:0005830)1.88545330
102Joint contractures involving the joints of the feet (HP:0100492)1.88545330
103Abnormal platelet volume (HP:0011876)1.87971851
104Elbow flexion contracture (HP:0002987)1.87470157
105Peritonitis (HP:0002586)1.85939984
106Calcaneovalgus deformity (HP:0001848)1.85168317
107Blue sclerae (HP:0000592)1.83853184
108Nephritis (HP:0000123)1.81718397
109Increased mean platelet volume (HP:0011877)1.80291375
110Urethral obstruction (HP:0000796)1.78096518
111Joint stiffness (HP:0001387)1.77427812
112J-shaped sella turcica (HP:0002680)1.77231189
113Bladder diverticulum (HP:0000015)1.77075849
114Genu recurvatum (HP:0002816)1.76150811
115Long eyelashes (HP:0000527)1.75951827
116Abnormality of the calcaneus (HP:0008364)1.75538028
117Recurrent fungal infections (HP:0002841)1.75495939
118Scapular winging (HP:0003691)1.74303829
119Hypertensive crisis (HP:0100735)1.74009015
120Bowing of the arm (HP:0006488)1.73618691
121Bowed forearm bones (HP:0003956)1.73618691
122Spondylolisthesis (HP:0003302)1.73510947
123Thrombocytosis (HP:0001894)1.73494418
124Hyporeflexia of lower limbs (HP:0002600)1.73324047
125Difficulty running (HP:0009046)1.73253813
126Persistence of primary teeth (HP:0006335)1.72744156
127Periodontitis (HP:0000704)1.72650518
128Selective tooth agenesis (HP:0001592)1.72280240
129Progressive external ophthalmoplegia (HP:0000590)1.71993633
130Glomerulonephritis (HP:0000099)1.71733957
131Hemorrhage of the eye (HP:0011885)1.70505060
132Emphysema (HP:0002097)1.70311582
133Knee flexion contracture (HP:0006380)1.70309465
134Hepatosplenomegaly (HP:0001433)1.69663699
135Gastrointestinal inflammation (HP:0004386)1.68561567
136Myocardial infarction (HP:0001658)1.68482313
137Muscle hypertrophy of the lower extremities (HP:0008968)1.68386574
138Chest pain (HP:0100749)1.68306854
139Fatigue (HP:0012378)1.67461180
140Osteomyelitis (HP:0002754)1.65931500
141Radial bowing (HP:0002986)1.65911959
142Muscle fiber splitting (HP:0003555)1.65735051
143Mesomelia (HP:0003027)1.63505512
144Gingivitis (HP:0000230)1.63098418
145Thoracic kyphosis (HP:0002942)1.62726068
146High pitched voice (HP:0001620)1.62391837
147Thin bony cortex (HP:0002753)1.62163498
148Impaired platelet aggregation (HP:0003540)1.61862960
149Abnormal platelet function (HP:0011869)1.61862960
150Dislocated radial head (HP:0003083)1.61801386
151Rectal prolapse (HP:0002035)1.61753732
152Difficulty climbing stairs (HP:0003551)1.61212896
153Recurrent gram-negative bacterial infections (HP:0005420)1.61132369
154Prolonged bleeding time (HP:0003010)1.60266530
155Atrophic scars (HP:0001075)1.59111600
156Renal duplication (HP:0000075)1.58854759
157Abnormality of the thoracic spine (HP:0100711)1.58420675
158Abnormality of the left ventricular outflow tract (HP:0011103)1.58026815
159Subaortic stenosis (HP:0001682)1.58026815
160Asymmetric septal hypertrophy (HP:0001670)1.57712083
161Arterial thrombosis (HP:0004420)1.57228093
162Broad ribs (HP:0000885)1.56518897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.78747263
2TTN3.55089352
3PKN23.21490181
4TGFBR22.77375576
5ERN12.76783147
6PRPF4B2.73764202
7MAP4K12.67722179
8MAP3K102.43114986
9CDK122.42790332
10SMG12.39340043
11MAP2K32.25306842
12PTK62.15999827
13RIPK42.06130750
14EEF2K2.03112977
15OBSCN1.98838939
16STK101.98588054
17RIPK11.86079022
18MUSK1.81196110
19PAK41.68117454
20LRRK21.63944775
21JAK31.63811721
22DMPK1.63489539
23TIE11.62939862
24TYK21.55356556
25ZAP701.49025707
26NEK21.45210098
27SIK11.44831500
28TAOK21.41475750
29CSF1R1.38489614
30IKBKB1.37016086
31CDC42BPA1.25195283
32PDGFRA1.24728643
33CAMK1D1.23186430
34TGFBR11.21782196
35KDR1.14931162
36PAK21.13436320
37RPS6KA41.07092040
38KSR21.06570200
39SIK21.05141980
40MAP3K11.04894182
41CSK1.04672517
42MYLK1.03431052
43TBK11.02880673
44FLT31.02063575
45NEK91.01267488
46CDK61.00902399
47MOS1.00481914
48KIT0.96116284
49BTK0.94731552
50MAP3K70.90427556
51PDPK10.89298185
52MAP3K60.88479480
53HCK0.88239371
54DDR20.87810406
55TAOK10.87688118
56JAK10.87567624
57TESK20.85243532
58PIK3CG0.85151020
59PTK2B0.84823487
60MAP3K140.84604192
61EPHB20.84435549
62MAP3K30.83908283
63STK30.83526885
64PDGFRB0.82719137
65ARAF0.82572826
66PRKG20.82482944
67MTOR0.82209894
68CAMK1G0.80869644
69MARK20.80249136
70MAP3K80.79941741
71PTK20.79773066
72EPHB10.78749669
73TRPM70.76665261
74CDK40.76432760
75PIM10.75943804
76MAPK110.74137366
77MAP3K110.73710671
78MAP2K60.73178504
79CHUK0.72749747
80RPS6KB20.72560114
81GRK60.72162418
82PHKG20.72158711
83PHKG10.72158711
84SIK30.71962060
85BMX0.70581758
86TNK20.70364285
87FES0.66926661
88CLK10.66324837
89MAPKAPK30.66285258
90MARK30.63674457
91EPHA20.63251808
92LCK0.62416436
93MAPK70.60902345
94ILK0.59008363
95BRD40.58476225
96CDC70.58397398
97ITK0.57636827
98FGR0.56687675
99ICK0.56116840
100FGFR40.56009547
101RPS6KA60.55533261
102MAPKAPK20.54667662
103RPS6KC10.54353716
104RPS6KL10.54353716
105MATK0.52969415
106IRAK20.52134760
107PDK10.51823465
108STK40.51795416
109NME20.50337348
110IRAK40.50101467
111IRAK30.49232832
112BRAF0.48903140
113JAK20.47052171
114MAP3K130.45205729
115CDK70.44887673
116TESK10.44012353
117EGFR0.43768846
118TEC0.43310675
119SYK0.43026504
120PRKD10.42387244
121LATS10.41793466
122BLK0.41428291
123MST40.40996065
124MST1R0.40474150
125LATS20.37948379
126AKT20.37781212
127MAP2K20.36639722
128MAPK40.35298206
129ALK0.34730348
130RPS6KA20.34600529
131MAPK120.33812058
132STK240.33615708
133PRKD20.33571924
134FGFR30.32941378
135INSR0.32734560

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.31194312
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16870633
3Leishmaniasis_Homo sapiens_hsa051402.02892410
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.87557607
5Osteoclast differentiation_Homo sapiens_hsa043801.81924205
6Leukocyte transendothelial migration_Homo sapiens_hsa046701.81201740
7Small cell lung cancer_Homo sapiens_hsa052221.77623459
8Pentose phosphate pathway_Homo sapiens_hsa000301.71045699
9Chronic myeloid leukemia_Homo sapiens_hsa052201.70419808
10Focal adhesion_Homo sapiens_hsa045101.70142252
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63710850
12Adherens junction_Homo sapiens_hsa045201.63135190
13Toxoplasmosis_Homo sapiens_hsa051451.62671765
14Viral myocarditis_Homo sapiens_hsa054161.61094276
15Fructose and mannose metabolism_Homo sapiens_hsa000511.58272917
16ECM-receptor interaction_Homo sapiens_hsa045121.57446885
17Staphylococcus aureus infection_Homo sapiens_hsa051501.57074967
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55981860
19Proteoglycans in cancer_Homo sapiens_hsa052051.46186315
20Apoptosis_Homo sapiens_hsa042101.44846371
21Platelet activation_Homo sapiens_hsa046111.43949778
22Acute myeloid leukemia_Homo sapiens_hsa052211.41664538
23Measles_Homo sapiens_hsa051621.39780836
24Base excision repair_Homo sapiens_hsa034101.37635148
25Antigen processing and presentation_Homo sapiens_hsa046121.35112734
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35110131
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34154182
28Influenza A_Homo sapiens_hsa051641.29622455
29Herpes simplex infection_Homo sapiens_hsa051681.27474350
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27175839
31Insulin resistance_Homo sapiens_hsa049311.26631654
32Notch signaling pathway_Homo sapiens_hsa043301.23942427
33Amoebiasis_Homo sapiens_hsa051461.22988815
34Galactose metabolism_Homo sapiens_hsa000521.21862833
35Hematopoietic cell lineage_Homo sapiens_hsa046401.20738755
36Malaria_Homo sapiens_hsa051441.19908601
37MicroRNAs in cancer_Homo sapiens_hsa052061.17144356
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16530421
39HTLV-I infection_Homo sapiens_hsa051661.16099800
40Pancreatic cancer_Homo sapiens_hsa052121.15458538
41Primary immunodeficiency_Homo sapiens_hsa053401.15372138
42Lysine degradation_Homo sapiens_hsa003101.14451592
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.14363027
44Shigellosis_Homo sapiens_hsa051311.13891284
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.11422981
46Tuberculosis_Homo sapiens_hsa051521.11363136
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10705603
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10666690
49Legionellosis_Homo sapiens_hsa051341.10272212
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10067020
51T cell receptor signaling pathway_Homo sapiens_hsa046601.09361824
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06687113
53Caffeine metabolism_Homo sapiens_hsa002321.06684603
54Pertussis_Homo sapiens_hsa051331.04748620
55Hepatitis B_Homo sapiens_hsa051611.00603738
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00271389
57TNF signaling pathway_Homo sapiens_hsa046681.00112956
58Viral carcinogenesis_Homo sapiens_hsa052030.98481414
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98287180
60Other glycan degradation_Homo sapiens_hsa005110.96856032
61Dilated cardiomyopathy_Homo sapiens_hsa054140.95602605
62HIF-1 signaling pathway_Homo sapiens_hsa040660.95302155
63DNA replication_Homo sapiens_hsa030300.95255784
64Thyroid cancer_Homo sapiens_hsa052160.95053604
65p53 signaling pathway_Homo sapiens_hsa041150.94715682
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93047204
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92545776
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91828584
69GnRH signaling pathway_Homo sapiens_hsa049120.90096163
70Chemokine signaling pathway_Homo sapiens_hsa040620.90064315
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89512478
72Non-homologous end-joining_Homo sapiens_hsa034500.88577167
73Allograft rejection_Homo sapiens_hsa053300.88540868
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87062484
75Salmonella infection_Homo sapiens_hsa051320.85697397
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.85498441
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85154860
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.84377676
79Phagosome_Homo sapiens_hsa041450.83917206
80Pathways in cancer_Homo sapiens_hsa052000.82663395
81Prion diseases_Homo sapiens_hsa050200.81987338
82Bladder cancer_Homo sapiens_hsa052190.80990647
83Graft-versus-host disease_Homo sapiens_hsa053320.80199471
84One carbon pool by folate_Homo sapiens_hsa006700.79465847
85VEGF signaling pathway_Homo sapiens_hsa043700.78942691
86Hepatitis C_Homo sapiens_hsa051600.77867796
87Prolactin signaling pathway_Homo sapiens_hsa049170.77837636
88mTOR signaling pathway_Homo sapiens_hsa041500.76600646
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75369021
90FoxO signaling pathway_Homo sapiens_hsa040680.75017288
91Prostate cancer_Homo sapiens_hsa052150.74434570
92Autoimmune thyroid disease_Homo sapiens_hsa053200.74157635
93Endometrial cancer_Homo sapiens_hsa052130.72418847
94Glioma_Homo sapiens_hsa052140.71637223
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70008468
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.69818251
97Epstein-Barr virus infection_Homo sapiens_hsa051690.69295409
98Colorectal cancer_Homo sapiens_hsa052100.69197364
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69057427
100Non-small cell lung cancer_Homo sapiens_hsa052230.68917673
101TGF-beta signaling pathway_Homo sapiens_hsa043500.68771602
102Rap1 signaling pathway_Homo sapiens_hsa040150.67563670
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67314641
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67069482
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.65633951
106Rheumatoid arthritis_Homo sapiens_hsa053230.63819490
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63127429
108Endocytosis_Homo sapiens_hsa041440.62556027
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.61625354
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60819825
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59970411
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59562822
113Carbon metabolism_Homo sapiens_hsa012000.58538119
114Cell cycle_Homo sapiens_hsa041100.58378417
115Lysosome_Homo sapiens_hsa041420.57482935
116Biosynthesis of amino acids_Homo sapiens_hsa012300.56796359
117PPAR signaling pathway_Homo sapiens_hsa033200.55602910
118Spliceosome_Homo sapiens_hsa030400.55151528
119Insulin signaling pathway_Homo sapiens_hsa049100.54129142
120RNA transport_Homo sapiens_hsa030130.53857530
121AMPK signaling pathway_Homo sapiens_hsa041520.53538243
122Protein digestion and absorption_Homo sapiens_hsa049740.53182951
123Asthma_Homo sapiens_hsa053100.53012654
124N-Glycan biosynthesis_Homo sapiens_hsa005100.52040349
125Hippo signaling pathway_Homo sapiens_hsa043900.52006927
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51346951
127Renal cell carcinoma_Homo sapiens_hsa052110.50920564
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50277807

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