FHL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.07596579
2cardiac myofibril assembly (GO:0055003)8.89782121
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.81748599
4myofibril assembly (GO:0030239)7.56567539
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.13917735
6negative regulation of potassium ion transmembrane transport (GO:1901380)7.10522688
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.84586414
8tricarboxylic acid cycle (GO:0006099)6.68528280
9cardiac muscle contraction (GO:0060048)6.66536815
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.55536597
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.31237461
12regulation of actin filament-based movement (GO:1903115)6.22525828
13regulation of relaxation of muscle (GO:1901077)6.14999669
14muscle filament sliding (GO:0030049)5.99157838
15actin-myosin filament sliding (GO:0033275)5.99157838
16ventricular cardiac muscle cell action potential (GO:0086005)5.87570718
17* cardiac muscle cell development (GO:0055013)5.87347514
18bundle of His cell to Purkinje myocyte communication (GO:0086069)5.86615102
19plasma membrane repair (GO:0001778)5.81061186
20cardiac muscle tissue morphogenesis (GO:0055008)5.70754521
21actomyosin structure organization (GO:0031032)5.70697683
22ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.69783112
23regulation of sarcomere organization (GO:0060297)5.66174425
24cardiac muscle hypertrophy (GO:0003300)5.54889707
25* cardiac cell development (GO:0055006)5.50800189
26adult heart development (GO:0007512)5.42072198
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.39002723
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.33127788
29striated muscle hypertrophy (GO:0014897)5.23363743
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.14041371
31muscle tissue morphogenesis (GO:0060415)5.07441988
32actin-mediated cell contraction (GO:0070252)5.01141455
33regulation of skeletal muscle contraction (GO:0014819)4.99464325
34regulation of cell communication by electrical coupling (GO:0010649)4.98365887
35regulation of striated muscle contraction (GO:0006942)4.95333846
36regulation of acyl-CoA biosynthetic process (GO:0050812)4.93617350
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.90082688
38regulation of the force of heart contraction (GO:0002026)4.85573286
39cell communication involved in cardiac conduction (GO:0086065)4.83893462
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.80858876
41striated muscle contraction (GO:0006941)4.79941708
42carnitine shuttle (GO:0006853)4.71767927
43heart contraction (GO:0060047)4.69432969
44heart process (GO:0003015)4.69432969
45regulation of membrane repolarization (GO:0060306)4.67416039
46regulation of cardiac muscle cell contraction (GO:0086004)4.62235820
47muscle hypertrophy (GO:0014896)4.61815008
48regulation of cofactor metabolic process (GO:0051193)4.55677196
49regulation of coenzyme metabolic process (GO:0051196)4.55677196
50ATP synthesis coupled proton transport (GO:0015986)4.53980391
51energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53980391
52* heart trabecula formation (GO:0060347)4.43320978
53regulation of cardiac muscle contraction (GO:0055117)4.43007052
54sarcoplasmic reticulum calcium ion transport (GO:0070296)4.37319545
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35019870
56cell communication by electrical coupling (GO:0010644)4.26919099
57respiratory electron transport chain (GO:0022904)4.25418678
58relaxation of cardiac muscle (GO:0055119)4.23103347
59electron transport chain (GO:0022900)4.12230182
60cell migration involved in heart development (GO:0060973)4.09645293
61regulation of heart rate (GO:0002027)4.08368692
62negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.07852577
63fatty acid transmembrane transport (GO:1902001)4.07485961
64cardiac muscle cell action potential involved in contraction (GO:0086002)4.07277112
65cardiac muscle cell action potential (GO:0086001)4.02742707
66oxidative phosphorylation (GO:0006119)4.01598120
67atrioventricular valve morphogenesis (GO:0003181)3.96561064
68negative regulation of potassium ion transport (GO:0043267)3.95656461
69NADH metabolic process (GO:0006734)3.95526915
70regulation of cardioblast differentiation (GO:0051890)3.95110619
71cardiac muscle adaptation (GO:0014887)3.94697823
72cardiac muscle hypertrophy in response to stress (GO:0014898)3.94697823
73muscle hypertrophy in response to stress (GO:0003299)3.94697823
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.92318528
75regulation of ATP catabolic process (GO:1903289)3.85968111
76regulation of ATPase activity (GO:0043462)3.85968111
77endocardial cushion development (GO:0003197)3.83487013
78regulation of heart contraction (GO:0008016)3.79593342
79negative regulation of striated muscle cell apoptotic process (GO:0010664)3.77947774
80actin filament-based movement (GO:0030048)3.77812326
81cardiac conduction (GO:0061337)3.76811003
82sequestering of extracellular ligand from receptor (GO:0035581)3.73988991
83negative regulation of protein localization to cell surface (GO:2000009)3.73807819
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.71983881
85atrial septum morphogenesis (GO:0060413)3.69617506
862-oxoglutarate metabolic process (GO:0006103)3.65862058
87regulation of sulfur metabolic process (GO:0042762)3.64561297
88positive regulation of heart contraction (GO:0045823)3.64377570
89positive regulation of heart rate (GO:0010460)3.62957115
90endodermal cell differentiation (GO:0035987)3.59110898
91epithelial cell-cell adhesion (GO:0090136)3.58219956
92oxygen transport (GO:0015671)3.57053945
93regulation of heart rate by cardiac conduction (GO:0086091)3.56669810
94carnitine transmembrane transport (GO:1902603)3.44911251
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.42758905
96positive regulation of cation channel activity (GO:2001259)3.41313316
97creatine metabolic process (GO:0006600)3.40652270
98hemidesmosome assembly (GO:0031581)3.38997509
99regulation of integrin-mediated signaling pathway (GO:2001044)3.38218362
100neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.37536820
101regulation of sequestering of triglyceride (GO:0010889)3.36871313
102detection of calcium ion (GO:0005513)3.35701642
103regulation of calcium ion transmembrane transport (GO:1903169)3.35460391
104regulation of calcium ion transmembrane transporter activity (GO:1901019)3.35460391
105collagen fibril organization (GO:0030199)3.35269884
106response to redox state (GO:0051775)3.34927513
107regulation of fatty acid oxidation (GO:0046320)3.28941491
108regulation of muscle contraction (GO:0006937)3.28280454
109cell-substrate junction assembly (GO:0007044)3.24148114
110desmosome organization (GO:0002934)3.23908779
111cell adhesion mediated by integrin (GO:0033627)3.19358152
112extracellular matrix assembly (GO:0085029)3.18836855
113actin filament depolymerization (GO:0030042)3.18804508
114chondrocyte proliferation (GO:0035988)3.18579603
115protein heterotrimerization (GO:0070208)3.16424011
116muscle contraction (GO:0006936)3.16253581
117* striated muscle cell development (GO:0055002)3.16199381
118pericardium development (GO:0060039)3.13632640
119carnitine transport (GO:0015879)3.12953199
120amino-acid betaine transport (GO:0015838)3.12953199
121bone trabecula formation (GO:0060346)3.10863363
122gap junction assembly (GO:0016264)3.08716501
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04863608
124regulation of tight junction assembly (GO:2000810)3.04842713
125skin morphogenesis (GO:0043589)3.00057942
126cardiac muscle tissue development (GO:0048738)2.99556799
127cardiac chamber formation (GO:0003207)2.95391870
128type B pancreatic cell proliferation (GO:0044342)2.92390720
129endothelial cell morphogenesis (GO:0001886)2.91007498
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90746454
131retina vasculature morphogenesis in camera-type eye (GO:0061299)2.84675104
132regulation of transforming growth factor beta2 production (GO:0032909)2.83614169
133outflow tract septum morphogenesis (GO:0003148)2.80885832
134venous blood vessel morphogenesis (GO:0048845)2.78280656
135lymphangiogenesis (GO:0001946)2.77647557
136negative regulation of chondrocyte differentiation (GO:0032331)2.74695681
137substrate adhesion-dependent cell spreading (GO:0034446)2.70682269
138adrenergic receptor signaling pathway (GO:0071875)2.70484488
139focal adhesion assembly (GO:0048041)2.70122849
140cell-substrate adherens junction assembly (GO:0007045)2.70122849
141kidney mesenchyme development (GO:0072074)2.67958853
142extracellular fibril organization (GO:0043206)2.63894782
143cellular response to vitamin (GO:0071295)2.62939323
144wound healing, spreading of epidermal cells (GO:0035313)2.61242427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.46581731
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.35674716
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.47737668
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.04937345
5TBX20_22328084_ChIP-Seq_HEART_Mouse4.03398032
6TBX20_22080862_ChIP-Seq_HEART_Mouse4.03398032
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.92296723
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.57662923
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35178279
10* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.11481997
11TRIM28_21343339_ChIP-Seq_HEK293_Human3.02543554
12ZNF263_19887448_ChIP-Seq_K562_Human3.00507191
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83098370
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.56468559
15BRD4_25478319_ChIP-Seq_HGPS_Human2.52770719
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.51460112
17* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.37186207
18EZH2_22144423_ChIP-Seq_EOC_Human2.33505800
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24106458
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24106458
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.23108886
22CLOCK_20551151_ChIP-Seq_293T_Human2.22111734
23* ESR1_20079471_ChIP-ChIP_T-47D_Human2.14546294
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08130124
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96731500
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90329247
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86245811
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.85355278
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79996423
30* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.79695746
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.74738267
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72659280
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69591528
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.62868932
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59619451
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53105106
37* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48179016
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47582545
39* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45959082
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37908200
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36131841
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33733676
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31354715
44CJUN_26792858_Chip-Seq_BT549_Human1.31147302
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30915256
46SOX2_20726797_ChIP-Seq_SW620_Human1.30563003
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30060733
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.26625226
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.26369996
50* TP53_22127205_ChIP-Seq_IMR90_Human1.25221434
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19770629
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19105682
53* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17968778
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17068775
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16261543
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.14747457
57SA1_22415368_ChIP-Seq_MEFs_Mouse1.14411876
58DROSHA_22980978_ChIP-Seq_HELA_Human1.14166680
59* ISL1_27105846_Chip-Seq_CPCs_Mouse1.13874293
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13488630
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12234123
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12219276
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11741962
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11082989
65* ATF3_27146783_Chip-Seq_COLON_Human1.10962633
66* EED_16625203_ChIP-ChIP_MESCs_Mouse1.10378132
67* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08919344
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08198086
69SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05599637
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05424978
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05424978
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03789425
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02195867
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00735829
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.00491684
76* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99512060
77CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98416256
78TP63_22573176_ChIP-Seq_HFKS_Human0.98245401
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97161604
80PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.97065992
81SMAD3_21741376_ChIP-Seq_HESCs_Human0.97015324
82* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96658623
83SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96575219
84RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96107581
85EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96107581
86RACK7_27058665_Chip-Seq_MCF-7_Human0.94909771
87KDM2B_26808549_Chip-Seq_DND41_Human0.94841068
88TP53_16413492_ChIP-PET_HCT116_Human0.94743144
89GATA1_22025678_ChIP-Seq_K562_Human0.94308022
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.94294303
91* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94063189
92* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93472545
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93193352
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93125965
95ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92503300
96CTCF_27219007_Chip-Seq_Bcells_Human0.91959093
97BCAT_22108803_ChIP-Seq_LS180_Human0.91669307
98* TP53_23651856_ChIP-Seq_MEFs_Mouse0.91544861
99NFI_21473784_ChIP-Seq_ESCs_Mouse0.90557793
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89426812
101* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88160588
102* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86617120
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86231594
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85706456
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85679633
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85268073
107LXR_22292898_ChIP-Seq_THP-1_Human0.85187650
108* TP63_23658742_ChIP-Seq_EP156T_Human0.85060062
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85041861
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84228305
111* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83954911
112GATA1_19941826_ChIP-Seq_K562_Human0.83545528
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83432237
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.83429471
115GATA4_25053715_ChIP-Seq_YYC3_Human0.83303504
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83239232
117AHR_22903824_ChIP-Seq_MCF-7_Human0.82481966
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.81475156
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.80635066
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80492745
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.79856808
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79758688
123* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79472209
124EZH2_27304074_Chip-Seq_ESCs_Mouse0.79374349
125* LXR_22158963_ChIP-Seq_LIVER_Mouse0.78885396
126* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77867215
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.77811610
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77247592
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.77001045
130* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76243429
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74990215
132* SOX2_21211035_ChIP-Seq_LN229_Gbm0.74164766
133FOXH1_21741376_ChIP-Seq_ESCs_Human0.73454806
134SPI1_20517297_ChIP-Seq_HL60_Human0.71801271
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71339975
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70723391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.84271556
2MP0004084_abnormal_cardiac_muscle5.99494667
3MP0003646_muscle_fatigue5.23594785
4MP0000751_myopathy4.96608002
5MP0004215_abnormal_myocardial_fiber4.95089240
6MP0004036_abnormal_muscle_relaxation4.13807627
7MP0005330_cardiomyopathy4.00711057
8MP0000749_muscle_degeneration3.51834560
9MP0002972_abnormal_cardiac_muscle3.25645974
10MP0008775_abnormal_heart_ventricle3.09692902
11MP0003137_abnormal_impulse_conducting2.96745402
12MP0004087_abnormal_muscle_fiber2.96595521
13MP0004484_altered_response_of2.73021360
14MP0001544_abnormal_cardiovascular_syste2.71691846
15MP0005385_cardiovascular_system_phenoty2.71691846
16MP0000750_abnormal_muscle_regeneration2.65977463
17MP0010630_abnormal_cardiac_muscle2.65022099
18MP0005620_abnormal_muscle_contractility2.62122027
19MP0006138_congestive_heart_failure2.57879558
20MP0003828_pulmonary_edema2.36263250
21MP0004130_abnormal_muscle_cell2.32013041
22MP0004085_abnormal_heartbeat2.26144412
23MP0002106_abnormal_muscle_physiology2.24456084
24MP0002269_muscular_atrophy2.08101123
25MP0004510_myositis1.96756243
26MP0003221_abnormal_cardiomyocyte_apopto1.91369605
27MP0005369_muscle_phenotype1.85709852
28MP0000759_abnormal_skeletal_muscle1.76917097
29MP0002127_abnormal_cardiovascular_syste1.68201998
30MP0005257_abnormal_intraocular_pressure1.67945380
31MP0000747_muscle_weakness1.65968759
32MP0004233_abnormal_muscle_weight1.64834155
33MP0008438_abnormal_cutaneous_collagen1.62361585
34MP0003279_aneurysm1.61535362
35MP0004145_abnormal_muscle_electrophysio1.61419133
36MP0005023_abnormal_wound_healing1.59364614
37MP0003950_abnormal_plasma_membrane1.57791814
38MP0006036_abnormal_mitochondrial_physio1.56189444
39MP0010368_abnormal_lymphatic_system1.40923268
40MP0010030_abnormal_orbit_morphology1.39794705
41MP0001542_abnormal_bone_strength1.31071624
42MP0000343_altered_response_to1.30636861
43MP0005165_increased_susceptibility_to1.26780125
44MP0005666_abnormal_adipose_tissue1.26695710
45MP0002060_abnormal_skin_morphology1.26319106
46MP0005508_abnormal_skeleton_morphology1.25843342
47MP0000762_abnormal_tongue_morphology1.25700343
48MP0003567_abnormal_fetal_cardiomyocyte1.25564858
49MP0005623_abnormal_meninges_morphology1.24492879
50MP0002332_abnormal_exercise_endurance1.23662474
51MP0006054_spinal_hemorrhage1.18020375
52* MP0000266_abnormal_heart_morphology1.17755751
53MP0009250_abnormal_appendicular_skeleto1.16355630
54MP0001661_extended_life_span1.12325485
55MP0005275_abnormal_skin_tensile1.10226276
56MP0003705_abnormal_hypodermis_morpholog1.07150225
57MP0002234_abnormal_pharynx_morphology1.06488804
58MP0001299_abnormal_eye_distance/1.06250106
59MP0003566_abnormal_cell_adhesion1.04198893
60MP0003283_abnormal_digestive_organ1.00518862
61MP0005670_abnormal_white_adipose0.99994117
62MP0010352_gastrointestinal_tract_polyps0.97762098
63MP0004272_abnormal_basement_membrane0.96155987
64MP0006035_abnormal_mitochondrial_morpho0.93188369
65MP0002128_abnormal_blood_circulation0.91462452
66MP0005375_adipose_tissue_phenotype0.90579327
67MP0000534_abnormal_ureter_morphology0.90424411
68MP0002108_abnormal_muscle_morphology0.89024288
69MP0000230_abnormal_systemic_arterial0.88661522
70MP0001879_abnormal_lymphatic_vessel0.84460781
71MP0001348_abnormal_lacrimal_gland0.83703018
72MP0005503_abnormal_tendon_morphology0.82129384
73MP0004185_abnormal_adipocyte_glucose0.81054340
74MP0000767_abnormal_smooth_muscle0.78403823
75MP0009384_cardiac_valve_regurgitation0.73626422
76MP0005197_abnormal_uvea_morphology0.72405451
77MP0009053_abnormal_anal_canal0.71227203
78MP0000013_abnormal_adipose_tissue0.71123588
79MP0000462_abnormal_digestive_system0.70277371
80MP0001958_emphysema0.70128664
81MP0005266_abnormal_metabolism0.69045432
82MP0000467_abnormal_esophagus_morphology0.67164781
83MP0000003_abnormal_adipose_tissue0.66002451
84MP0001243_abnormal_dermal_layer0.65695965
85MP0010386_abnormal_urinary_bladder0.65375611
86MP0003385_abnormal_body_wall0.64664286
87MP0005171_absent_coat_pigmentation0.63919221
88MP0002909_abnormal_adrenal_gland0.62077958
89MP0003942_abnormal_urinary_system0.60109783
90MP0000538_abnormal_urinary_bladder0.56871184
91MP0003755_abnormal_palate_morphology0.56315261
92MP0002295_abnormal_pulmonary_circulatio0.55695899
93MP0000579_abnormal_nail_morphology0.55595798
94MP0002168_other_aberrant_phenotype0.55585679
95MP0000163_abnormal_cartilage_morphology0.55096049
96MP0005187_abnormal_penis_morphology0.53839059
97MP0002925_abnormal_cardiovascular_devel0.53597254
98MP0005193_abnormal_anterior_eye0.52539728
99MP0003806_abnormal_nucleotide_metabolis0.51856332
100MP0000733_abnormal_muscle_development0.51380760
101MP0005409_darkened_coat_color0.50530513
102MP0004043_abnormal_pH_regulation0.49529854
103MP0001614_abnormal_blood_vessel0.46231935
104MP0005595_abnormal_vascular_smooth0.46046751
105MP0003984_embryonic_growth_retardation0.44225568
106MP0002088_abnormal_embryonic_growth/wei0.42613296
107MP0005319_abnormal_enzyme/_coenzyme0.38619018
108MP0001784_abnormal_fluid_regulation0.38178190
109MP0002078_abnormal_glucose_homeostasis0.36225348
110MP0009780_abnormal_chondrocyte_physiolo0.36012430
111MP0005451_abnormal_body_composition0.35059490
112MP0002971_abnormal_brown_adipose0.34872431
113MP0001727_abnormal_embryo_implantation0.34114378
114MP0003091_abnormal_cell_migration0.31559637
115MP0002877_abnormal_melanocyte_morpholog0.30661053
116MP0008961_abnormal_basal_metabolism0.30313219
117MP0005388_respiratory_system_phenotype0.30094741
118MP0002133_abnormal_respiratory_system0.30094741
119MP0003941_abnormal_skin_development0.29609262
120MP0003195_calcinosis0.29514666
121MP0003948_abnormal_gas_homeostasis0.28183637
122MP0008004_abnormal_stomach_pH0.27802994
123MP0000249_abnormal_blood_vessel0.27155464
124MP0004147_increased_porphyrin_level0.26854525
125MP0003045_fibrosis0.26447659
126MP0004924_abnormal_behavior0.25595359
127MP0005386_behavior/neurological_phenoty0.25595359
128MP0005535_abnormal_body_temperature0.24234040
129MP0001672_abnormal_embryogenesis/_devel0.22027948
130MP0005380_embryogenesis_phenotype0.22027948
131MP0002896_abnormal_bone_mineralization0.19482790

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.27438133
2Ventricular tachycardia (HP:0004756)7.26797052
3Atrial fibrillation (HP:0005110)6.54705246
4Primary atrial arrhythmia (HP:0001692)6.13436689
5Calf muscle hypertrophy (HP:0008981)5.95510562
6Supraventricular tachycardia (HP:0004755)5.93109672
7Supraventricular arrhythmia (HP:0005115)5.82845192
8Protrusio acetabuli (HP:0003179)5.51719732
9Right ventricular cardiomyopathy (HP:0011663)5.47368745
10Premature rupture of membranes (HP:0001788)5.41848530
11* Lipoatrophy (HP:0100578)5.33190971
12Muscle hypertrophy of the lower extremities (HP:0008968)5.31207155
13Syncope (HP:0001279)5.22092078
14Muscle fiber splitting (HP:0003555)5.21192929
15Exercise-induced muscle cramps (HP:0003710)5.15808289
16Abnormality of the calf musculature (HP:0001430)5.14026749
17Exercise-induced myalgia (HP:0003738)4.89039936
18Bundle branch block (HP:0011710)4.78635189
19Palpitations (HP:0001962)4.69187008
20Type 1 muscle fiber predominance (HP:0003803)4.62719395
21Dilated cardiomyopathy (HP:0001644)4.56549064
22Hyporeflexia of lower limbs (HP:0002600)4.55276216
23Prolonged QT interval (HP:0001657)4.54571704
24Subaortic stenosis (HP:0001682)4.52693200
25Abnormality of the left ventricular outflow tract (HP:0011103)4.52693200
26Myoglobinuria (HP:0002913)4.45765601
27Ventricular arrhythmia (HP:0004308)4.23482959
28Aortic aneurysm (HP:0004942)4.01423614
29Heart block (HP:0012722)3.93795125
30Ventricular fibrillation (HP:0001663)3.89781098
31Increased connective tissue (HP:0009025)3.85166791
32Aortic dissection (HP:0002647)3.81173421
33Abnormal atrioventricular conduction (HP:0005150)3.80858145
34EMG: myopathic abnormalities (HP:0003458)3.80233828
35Atrioventricular block (HP:0001678)3.80188445
36Asymmetric septal hypertrophy (HP:0001670)3.79239466
37Vascular tortuosity (HP:0004948)3.75366537
38Arterial tortuosity (HP:0005116)3.41648102
39Rhabdomyolysis (HP:0003201)3.34913879
40Ankle contracture (HP:0006466)3.30453094
41Abnormal mitochondria in muscle tissue (HP:0008316)3.27240565
42Acute necrotizing encephalopathy (HP:0006965)3.24887216
43Abnormal EKG (HP:0003115)3.22770074
44Myotonia (HP:0002486)3.13501760
45Atrophic scars (HP:0001075)3.11427822
46Hepatic necrosis (HP:0002605)3.10539592
47Soft skin (HP:0000977)3.02931853
48Left ventricular hypertrophy (HP:0001712)2.99774316
49Spinal rigidity (HP:0003306)2.96108376
50Fragile skin (HP:0001030)2.92721970
51Difficulty running (HP:0009046)2.91844370
52Follicular hyperkeratosis (HP:0007502)2.89421183
53Difficulty climbing stairs (HP:0003551)2.83474623
54Wormian bones (HP:0002645)2.82961323
55Acute encephalopathy (HP:0006846)2.74258301
56Ketoacidosis (HP:0001993)2.73863125
57Distal lower limb muscle weakness (HP:0009053)2.71620001
58Progressive macrocephaly (HP:0004481)2.70284631
59Hepatocellular necrosis (HP:0001404)2.68663255
60Bradycardia (HP:0001662)2.68267692
61Bladder diverticulum (HP:0000015)2.67476528
62Hypoglycemic coma (HP:0001325)2.61436972
63Mitochondrial inheritance (HP:0001427)2.57772584
64* Palmoplantar keratoderma (HP:0000982)2.57267164
65Conjunctival hamartoma (HP:0100780)2.56466121
66Cerebral edema (HP:0002181)2.46693257
67Increased CSF lactate (HP:0002490)2.44448911
68Testicular atrophy (HP:0000029)2.43526893
69Abnormality of fatty-acid metabolism (HP:0004359)2.41698518
70Abnormality of dentin (HP:0010299)2.41650222
71Ragged-red muscle fibers (HP:0003200)2.41611954
72Limb-girdle muscle atrophy (HP:0003797)2.41133588
73Increased variability in muscle fiber diameter (HP:0003557)2.40342857
74Abnormality of the tricuspid valve (HP:0001702)2.38363289
75Dicarboxylic aciduria (HP:0003215)2.37706015
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37706015
77Increased muscle lipid content (HP:0009058)2.36597560
78Centrally nucleated skeletal muscle fibers (HP:0003687)2.34689892
79Generalized amyotrophy (HP:0003700)2.31592553
80Cervical subluxation (HP:0003308)2.30805439
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30099604
82Abnormality of alanine metabolism (HP:0010916)2.30099604
83Hyperalaninemia (HP:0003348)2.30099604
84Aneurysm (HP:0002617)2.29199058
85Pheochromocytoma (HP:0002666)2.25741811
86Sudden cardiac death (HP:0001645)2.25129149
87Broad metatarsal (HP:0001783)2.21710480
88Spondylolisthesis (HP:0003302)2.20426910
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.19250688
90Osteolytic defects of the hand bones (HP:0009699)2.19250688
91Exercise intolerance (HP:0003546)2.19035760
92Respiratory failure (HP:0002878)2.18974379
93Elbow flexion contracture (HP:0002987)2.18220866
94Lactic acidosis (HP:0003128)2.16493091
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14877988
96Congestive heart failure (HP:0001635)2.12941506
97Neoplasm of the adrenal gland (HP:0100631)2.12700245
98Vertebral compression fractures (HP:0002953)2.12538375
99Areflexia of lower limbs (HP:0002522)2.12186868
100Reduced subcutaneous adipose tissue (HP:0003758)2.10782325
101Wrist flexion contracture (HP:0001239)2.09720941
102Increased intramyocellular lipid droplets (HP:0012240)2.09660536
103Distal lower limb amyotrophy (HP:0008944)2.09308815
104Nemaline bodies (HP:0003798)2.08470438
105Mitral regurgitation (HP:0001653)2.07994445
106Abnormality of skeletal muscle fiber size (HP:0012084)2.06804817
107Neonatal short-limb short stature (HP:0008921)2.04709001
108Aortic regurgitation (HP:0001659)2.03614913
109Dysmetric saccades (HP:0000641)2.02428311
110Neuroendocrine neoplasm (HP:0100634)2.02353649
111Dilatation of the ascending aorta (HP:0005111)2.02195024
112Hypoplastic ischia (HP:0003175)2.01065756
113Muscle stiffness (HP:0003552)2.00258744
114Hamartoma of the eye (HP:0010568)2.00227048
115Blue sclerae (HP:0000592)1.99106939
116Abnormality of the foot musculature (HP:0001436)1.98861199
117Scapular winging (HP:0003691)1.98612980
118Hip contracture (HP:0003273)1.96551805
119Neck muscle weakness (HP:0000467)1.94661401
120EMG: neuropathic changes (HP:0003445)1.93575645
121Hypoplastic heart (HP:0001961)1.93295856
122Shallow orbits (HP:0000586)1.93249920
123Mitral valve prolapse (HP:0001634)1.92749675
124Neoplasm of head and neck (HP:0012288)1.92561831
125Esophageal neoplasm (HP:0100751)1.92561831
126Mitral stenosis (HP:0001718)1.91251599
127Foot dorsiflexor weakness (HP:0009027)1.90456688
128Round ear (HP:0100830)1.89361536
129Ketosis (HP:0001946)1.86925662
130Muscle fiber inclusion bodies (HP:0100299)1.86916693
131Cardiovascular calcification (HP:0011915)1.86232080
132Mildly elevated creatine phosphokinase (HP:0008180)1.85280290
133Aplasia of the musculature (HP:0100854)1.84738553
134Lymphangioma (HP:0100764)1.84529560
135Delayed gross motor development (HP:0002194)1.83899223
136Muscular dystrophy (HP:0003560)1.81762106
137Abnormality of glycolysis (HP:0004366)1.80709813
138Increased serum pyruvate (HP:0003542)1.80709813
139Athetosis (HP:0002305)1.79858220
140Limited hip movement (HP:0008800)1.79517604
141Coronal craniosynostosis (HP:0004440)1.77555659
142Generalized muscle weakness (HP:0003324)1.77534626
143Double outlet right ventricle (HP:0001719)1.76069049
144Congenital malformation of the right heart (HP:0011723)1.76069049
145Pulmonary artery stenosis (HP:0004415)1.75138722
146Genu recurvatum (HP:0002816)1.74994215
147Large for gestational age (HP:0001520)1.74917761
148Short nail (HP:0001799)1.74369681
149Hypoplastic left heart (HP:0004383)1.74311927
150Central scotoma (HP:0000603)1.73069504
151Abnormality of the ischium (HP:0003174)1.73011851
152Hyperinsulinemic hypoglycemia (HP:0000825)1.72773791
153Facial diplegia (HP:0001349)1.71959738
154Knee flexion contracture (HP:0006380)1.71664604
155Slender build (HP:0001533)1.71598527
156Hypoventilation (HP:0002791)1.69460026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.17907970
2MYLK4.43040813
3LMTK24.20890682
4PDK33.67095159
5PDK43.67095159
6PHKG23.45781342
7PHKG13.45781342
8PKN23.35459880
9DMPK3.17749929
10OBSCN3.09321528
11TRIB32.83113830
12PIK3CA2.55892261
13EPHA22.52958104
14STK242.25994998
15PDK22.25552500
16MST1R2.25135948
17MET2.21459524
18BCKDK2.15554255
19NEK12.10772624
20TIE12.06843932
21PTK22.03565448
22MUSK1.97498552
23PAK31.83021383
24PINK11.70985806
25TESK11.64706162
26GRK71.64081778
27PAK41.53967638
28CAMK2D1.47294357
29MAP3K121.46357535
30PRKD11.39829340
31ILK1.35121468
32STK38L1.30422256
33WNK41.18236497
34ROCK11.17300332
35MAP3K61.16551723
36CDC42BPA1.12746213
37TRPM71.09434404
38NTRK11.06602628
39PDGFRA1.06557151
40DAPK31.02454612
41ERBB40.98950123
42STK40.96153162
43PIM20.92732509
44PTK2B0.91917492
45ZAK0.91302409
46MAP3K50.87453884
47RIPK10.84437476
48MAPKAPK30.83427985
49MAPK120.82506028
50CAMK40.81808230
51FLT30.81302123
52CDK80.80078882
53KDR0.79840085
54MAP3K70.79639750
55PIK3CG0.79578238
56ABL20.77412767
57STK380.76364872
58ROCK20.76080094
59CAMK2A0.75175002
60NME20.73190147
61STK30.71610260
62LATS20.71565925
63PRKAA10.70926710
64PRKD20.70751205
65PRKAA20.70565005
66WNK10.64041137
67INSRR0.63123840
68CAMK10.60279597
69TGFBR20.59995256
70AKT30.58851526
71MOS0.58462408
72MAP3K30.57651807
73BRSK20.57600956
74PKN10.57144876
75FER0.54706987
76PRKCE0.54423069
77RPS6KL10.54382880
78RPS6KC10.54382880
79MST40.52318377
80EPHB20.50298460
81STK390.49741276
82PRKACB0.46016277
83RPS6KA60.45028204
84MELK0.42562579
85MAP2K30.41386490
86LATS10.41108358
87NEK90.40736203
88EIF2AK10.40642346
89ERN10.39834959
90PAK10.39288918
91PRKACA0.37249584
92PRKACG0.36217943
93ARAF0.35915718
94PRKD30.35814239
95LIMK10.35794790
96CAMK2G0.35375691
97PRKG20.34721361
98PTK60.34448245
99PDPK10.34135746
100BMX0.33116247
101GSK3A0.31691663
102RPS6KA20.30610738
103RET0.29918744
104EPHB10.29584302
105PAK60.29546014
106PRKCH0.29181064
107PBK0.27875212
108PDK10.25637850
109ICK0.23478299
110AKT20.23083258
111PAK20.20772602
112LRRK20.20473720
113RPS6KA10.19878082
114DDR20.18366685
115PDGFRB0.18277081
116MTOR0.16341960
117MAP2K10.15277027
118ADRBK10.14481876
119PRKG10.13106715
120MAP3K40.12641841
121EPHA30.12528086
122MAPK70.12276336
123JAK10.11757713
124SIK10.11491881
125TGFBR10.11420625
126CAMK2B0.10624987
127MAPKAPK20.09586851
128TAOK10.08962748
129SGK10.08825485

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.04739841
2Cardiac muscle contraction_Homo sapiens_hsa042604.32700145
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.18444649
4Dilated cardiomyopathy_Homo sapiens_hsa054143.86961574
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.70566047
6Parkinsons disease_Homo sapiens_hsa050123.41284510
7Oxidative phosphorylation_Homo sapiens_hsa001903.36204919
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11513817
9Propanoate metabolism_Homo sapiens_hsa006403.08116680
10Fatty acid degradation_Homo sapiens_hsa000712.77495363
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54966703
12Alzheimers disease_Homo sapiens_hsa050102.54964494
13Carbon metabolism_Homo sapiens_hsa012002.39558797
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23934692
15Huntingtons disease_Homo sapiens_hsa050162.17473267
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15368643
17Fatty acid metabolism_Homo sapiens_hsa012122.06132971
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84116095
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76672557
20Pyruvate metabolism_Homo sapiens_hsa006201.73800890
21Viral myocarditis_Homo sapiens_hsa054161.72890726
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35376487
23Sulfur relay system_Homo sapiens_hsa041221.26260263
24Butanoate metabolism_Homo sapiens_hsa006501.26247237
25Sulfur metabolism_Homo sapiens_hsa009201.25745900
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22206181
27Hippo signaling pathway_Homo sapiens_hsa043901.15936300
28Fatty acid elongation_Homo sapiens_hsa000621.15662840
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13578080
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13102114
31TGF-beta signaling pathway_Homo sapiens_hsa043501.10869298
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05044002
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03350252
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02503142
35Focal adhesion_Homo sapiens_hsa045100.98451010
36Biosynthesis of amino acids_Homo sapiens_hsa012300.96644192
37PPAR signaling pathway_Homo sapiens_hsa033200.91055161
38Insulin resistance_Homo sapiens_hsa049310.89549856
39Glucagon signaling pathway_Homo sapiens_hsa049220.89403447
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86927813
41ECM-receptor interaction_Homo sapiens_hsa045120.85968871
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83681946
43Hedgehog signaling pathway_Homo sapiens_hsa043400.83146950
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.83145713
45Starch and sucrose metabolism_Homo sapiens_hsa005000.79513394
46Bladder cancer_Homo sapiens_hsa052190.78755430
47HIF-1 signaling pathway_Homo sapiens_hsa040660.76779256
48Calcium signaling pathway_Homo sapiens_hsa040200.75071494
49Insulin signaling pathway_Homo sapiens_hsa049100.74579300
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74069511
51Pathways in cancer_Homo sapiens_hsa052000.67539929
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.66382415
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.65548865
54Oxytocin signaling pathway_Homo sapiens_hsa049210.65200730
55Lysine degradation_Homo sapiens_hsa003100.64268073
56Tryptophan metabolism_Homo sapiens_hsa003800.62658993
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62510830
58Arginine and proline metabolism_Homo sapiens_hsa003300.58895396
59Glutathione metabolism_Homo sapiens_hsa004800.56789296
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55877115
61Melanogenesis_Homo sapiens_hsa049160.55599419
62p53 signaling pathway_Homo sapiens_hsa041150.55546674
63Basal cell carcinoma_Homo sapiens_hsa052170.54728558
64Type II diabetes mellitus_Homo sapiens_hsa049300.54616235
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54445743
66AMPK signaling pathway_Homo sapiens_hsa041520.54375086
67Tight junction_Homo sapiens_hsa045300.52027574
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51583466
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51340620
70Arginine biosynthesis_Homo sapiens_hsa002200.50924252
71Thyroid hormone synthesis_Homo sapiens_hsa049180.50161274
72beta-Alanine metabolism_Homo sapiens_hsa004100.49869816
73Renin secretion_Homo sapiens_hsa049240.49557722
74cAMP signaling pathway_Homo sapiens_hsa040240.49353812
75Vibrio cholerae infection_Homo sapiens_hsa051100.49130156
76Adherens junction_Homo sapiens_hsa045200.49007756
77Mineral absorption_Homo sapiens_hsa049780.47928822
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.47531774
79Gastric acid secretion_Homo sapiens_hsa049710.47000345
80Galactose metabolism_Homo sapiens_hsa000520.46387735
81Amoebiasis_Homo sapiens_hsa051460.44611615
82Pentose phosphate pathway_Homo sapiens_hsa000300.44295912
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43757580
84Sphingolipid metabolism_Homo sapiens_hsa006000.41930685
85Axon guidance_Homo sapiens_hsa043600.41429438
86N-Glycan biosynthesis_Homo sapiens_hsa005100.39491203
87Insulin secretion_Homo sapiens_hsa049110.37645779
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36621769
89Circadian entrainment_Homo sapiens_hsa047130.36314387
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36202293
91Proteoglycans in cancer_Homo sapiens_hsa052050.35420355
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34742903
93Prion diseases_Homo sapiens_hsa050200.34690342
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34415286
95Peroxisome_Homo sapiens_hsa041460.34059099
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33723493
97Phenylalanine metabolism_Homo sapiens_hsa003600.32541231
98Selenocompound metabolism_Homo sapiens_hsa004500.31618973
99Cocaine addiction_Homo sapiens_hsa050300.31480698
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30918250
101Gap junction_Homo sapiens_hsa045400.30578441
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29777009
103Fructose and mannose metabolism_Homo sapiens_hsa000510.28961756
104Fatty acid biosynthesis_Homo sapiens_hsa000610.28910236
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.26224486
106Renal cell carcinoma_Homo sapiens_hsa052110.23486894
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23232299
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20930302
109GnRH signaling pathway_Homo sapiens_hsa049120.20631716
110Platelet activation_Homo sapiens_hsa046110.20460079
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20363816
112Metabolic pathways_Homo sapiens_hsa011000.20179542
113VEGF signaling pathway_Homo sapiens_hsa043700.18733309
114Small cell lung cancer_Homo sapiens_hsa052220.18180470
115Ovarian steroidogenesis_Homo sapiens_hsa049130.16214515
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15978164
117Cholinergic synapse_Homo sapiens_hsa047250.15329722
118Dorso-ventral axis formation_Homo sapiens_hsa043200.14587702
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14036646
120Rap1 signaling pathway_Homo sapiens_hsa040150.12444881
121Estrogen signaling pathway_Homo sapiens_hsa049150.12394583
122Pancreatic secretion_Homo sapiens_hsa049720.12042117
123Taste transduction_Homo sapiens_hsa047420.11605965
124Circadian rhythm_Homo sapiens_hsa047100.09703898
125Protein digestion and absorption_Homo sapiens_hsa049740.09118541
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.08376099
127Fat digestion and absorption_Homo sapiens_hsa049750.08296551
128Toxoplasmosis_Homo sapiens_hsa051450.07447904
129mTOR signaling pathway_Homo sapiens_hsa041500.07439436
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06049031
131Salivary secretion_Homo sapiens_hsa049700.05318698
132Melanoma_Homo sapiens_hsa052180.04134959
133Long-term potentiation_Homo sapiens_hsa047200.03832936

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