FGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)6.56560359
2response to peptidoglycan (GO:0032494)6.02533859
3neutrophil activation involved in immune response (GO:0002283)5.99510789
4cellular extravasation (GO:0045123)5.45747990
5respiratory burst (GO:0045730)5.34403430
6positive regulation by symbiont of host defense response (GO:0052509)5.25876491
7modulation by symbiont of host defense response (GO:0052031)5.25876491
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.25876491
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.25876491
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.25876491
11modulation by symbiont of host immune response (GO:0052553)5.25876491
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19110369
13production of molecular mediator involved in inflammatory response (GO:0002532)5.18266251
14regulation of B cell receptor signaling pathway (GO:0050855)4.91111992
15immunoglobulin mediated immune response (GO:0016064)4.64416232
16neutrophil activation (GO:0042119)4.61119971
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59522108
18granulocyte activation (GO:0036230)4.53972672
19leukocyte migration involved in inflammatory response (GO:0002523)4.27562375
20regulation of gamma-delta T cell activation (GO:0046643)4.27105311
21negative regulation of interleukin-12 production (GO:0032695)4.21611740
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.11144492
23response to host immune response (GO:0052572)4.08932316
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08932316
25hydrogen peroxide biosynthetic process (GO:0050665)4.08549332
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05625365
27neutrophil mediated immunity (GO:0002446)4.00901552
28detection of biotic stimulus (GO:0009595)3.93889201
29cellular response to zinc ion (GO:0071294)3.93339566
30macrophage activation involved in immune response (GO:0002281)3.90361578
31regulation of integrin activation (GO:0033623)3.89324628
32regulation of podosome assembly (GO:0071801)3.88788048
33superoxide anion generation (GO:0042554)3.85792460
34response to host (GO:0075136)3.74873524
35response to host defenses (GO:0052200)3.74873524
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74873524
37neutrophil chemotaxis (GO:0030593)3.74824998
38regulation of interferon-beta biosynthetic process (GO:0045357)3.71478106
39negative regulation of leukocyte mediated immunity (GO:0002704)3.67070281
40leukocyte cell-cell adhesion (GO:0007159)3.66258217
41negative regulation of T cell mediated immunity (GO:0002710)3.64970576
42neutrophil migration (GO:1990266)3.64069972
43antigen processing and presentation via MHC class Ib (GO:0002475)3.63264621
44detection of other organism (GO:0098543)3.62393326
45positive regulation of interferon-alpha production (GO:0032727)3.58317657
46reactive oxygen species biosynthetic process (GO:1903409)3.57658426
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56597227
48negative regulation of cell killing (GO:0031342)3.56597227
49B cell mediated immunity (GO:0019724)3.56513389
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.54640182
51positive regulation of protein homooligomerization (GO:0032464)3.52951933
52regulation of gamma-delta T cell differentiation (GO:0045586)3.52194064
53response to fungus (GO:0009620)3.49812374
54defense response to fungus (GO:0050832)3.48420862
55positive regulation of gamma-delta T cell activation (GO:0046645)3.47734947
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.46349346
57response to interleukin-15 (GO:0070672)3.44860500
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43117324
59regulation of interferon-alpha production (GO:0032647)3.38766428
60detection of bacterium (GO:0016045)3.38746194
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34481432
62* regulation of mast cell activation (GO:0033003)3.33534617
63disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.33333405
64killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.33333405
65* regulation of mast cell degranulation (GO:0043304)3.31461081
66response to muramyl dipeptide (GO:0032495)3.31423190
67regulation of tolerance induction (GO:0002643)3.30491101
68type I interferon signaling pathway (GO:0060337)3.29696008
69cellular response to type I interferon (GO:0071357)3.29696008
70regulation of B cell differentiation (GO:0045577)3.29101637
71myeloid cell activation involved in immune response (GO:0002275)3.27850359
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27760513
73regulation of T cell tolerance induction (GO:0002664)3.27469406
74response to type I interferon (GO:0034340)3.26553150
75* positive regulation of mast cell activation (GO:0033005)3.26473361
76negative regulation of erythrocyte differentiation (GO:0045647)3.24968062
77* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24250673
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.23141834
79antigen processing and presentation of endogenous antigen (GO:0019883)3.20212102
80positive regulation of B cell differentiation (GO:0045579)3.19969958
81granulocyte chemotaxis (GO:0071621)3.19438604
82germinal center formation (GO:0002467)3.19260542
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16622852
84positive regulation of interferon-beta production (GO:0032728)3.14429838
85granulocyte migration (GO:0097530)3.13307418
86leukocyte mediated cytotoxicity (GO:0001909)3.12843749
87positive regulation of antigen processing and presentation (GO:0002579)3.11038769
88cellular response to interleukin-15 (GO:0071350)3.10478743
89* regulation of leukocyte degranulation (GO:0043300)3.07893836
90positive regulation of lamellipodium assembly (GO:0010592)3.07739228
91regulation of T-helper 2 cell differentiation (GO:0045628)3.06568310
92leukotriene metabolic process (GO:0006691)3.06113620
93interferon-gamma-mediated signaling pathway (GO:0060333)3.05731909
94* regulation of mast cell activation involved in immune response (GO:0033006)3.05623092
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03192376
96positive thymic T cell selection (GO:0045059)3.01722024
97response to protozoan (GO:0001562)3.01539628
98myeloid leukocyte mediated immunity (GO:0002444)3.00316136
99positive regulation of toll-like receptor signaling pathway (GO:0034123)2.99405291
100negative regulation of innate immune response (GO:0045824)2.98754433
101negative regulation of cytokine production involved in immune response (GO:0002719)2.98453350
102negative regulation of phagocytosis (GO:0050765)2.98330047
103myeloid leukocyte activation (GO:0002274)2.96967615
104sequestering of metal ion (GO:0051238)2.96712185
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96168940
106activated T cell proliferation (GO:0050798)2.95370811
107regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94785378
108regulation of natural killer cell mediated immunity (GO:0002715)2.94785378
109lipoxygenase pathway (GO:0019372)2.94244818
110chronic inflammatory response (GO:0002544)2.93705882
111regulation of T cell mediated cytotoxicity (GO:0001914)2.92796292
112negative thymic T cell selection (GO:0045060)2.92146741
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91343653
114regulation of alpha-beta T cell proliferation (GO:0046640)2.88266136
115positive regulation of chemokine biosynthetic process (GO:0045080)2.87329372
116detection of external biotic stimulus (GO:0098581)2.86905461
117regulation of antigen processing and presentation (GO:0002577)2.86364628
118defense response to protozoan (GO:0042832)2.85653592
119negative regulation of mast cell activation (GO:0033004)2.84536161
120positive regulation of cellular amide metabolic process (GO:0034250)2.83320053
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82087083
122negative regulation of interleukin-6 production (GO:0032715)2.80829643
123regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79845843
124embryonic process involved in female pregnancy (GO:0060136)2.78808868
125T cell migration (GO:0072678)2.78546346
126positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77024259
127B cell receptor signaling pathway (GO:0050853)2.76108296
128leukocyte degranulation (GO:0043299)2.75872404
129regulation of T-helper 1 cell differentiation (GO:0045625)2.75419955
130detection of molecule of bacterial origin (GO:0032490)2.74540411
131microglial cell activation (GO:0001774)2.73467739
132macrophage activation (GO:0042116)2.72790787
133cytokine secretion (GO:0050663)2.72628464
134positive regulation of protein oligomerization (GO:0032461)2.71653161
135T-helper 1 type immune response (GO:0042088)2.68904637
136* positive regulation of mast cell activation involved in immune response (GO:0033008)2.67665984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.96899262
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.92694233
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.70151201
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.74670251
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63057329
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57700914
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.37503171
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21668590
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.14247716
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06339605
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05563897
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.94036555
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80382002
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79323243
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63308379
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57081975
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.56016700
18VDR_21846776_ChIP-Seq_THP-1_Human2.54643129
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42541353
20* SPI1_23547873_ChIP-Seq_NB4_Human2.34619491
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22655659
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19019575
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18021650
24VDR_24763502_ChIP-Seq_THP-1_Human2.15943962
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14898199
26* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05706886
27* MAF_26560356_Chip-Seq_TH1_Human1.98407882
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.91010919
29SPI1_23127762_ChIP-Seq_K562_Human1.83868998
30MYB_26560356_Chip-Seq_TH2_Human1.83531023
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76079282
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75174416
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73309559
34PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.68680264
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66788683
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66704705
37* PU_27001747_Chip-Seq_BMDM_Mouse1.65884085
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65042434
39MYC_22102868_ChIP-Seq_BL_Human1.64311596
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63594024
41MYB_26560356_Chip-Seq_TH1_Human1.62396374
42UTX_26944678_Chip-Seq_JUKART_Human1.61318613
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59127376
44RUNX_20019798_ChIP-Seq_JUKART_Human1.58715222
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54852888
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52606227
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52104964
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.52045615
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51829299
50SCL_19346495_ChIP-Seq_HPC-7_Human1.51508908
51TCF7_22412390_ChIP-Seq_EML_Mouse1.49852008
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45403074
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40323454
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37431554
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36098100
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35471511
57GATA1_22025678_ChIP-Seq_K562_Human1.34662573
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31843900
59* KDM2B_26808549_Chip-Seq_DND41_Human1.31334823
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31316925
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.30598722
62* LXR_22292898_ChIP-Seq_THP-1_Human1.30554493
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29574496
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29219800
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28189814
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27230338
67VDR_24787735_ChIP-Seq_THP-1_Human1.25240251
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24753593
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24416016
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23858233
71MAF_26560356_Chip-Seq_TH2_Human1.21887128
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21225446
73* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20829274
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17405418
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15964490
76* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14416466
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11488122
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09815485
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09732611
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09478135
81SPI1_20517297_ChIP-Seq_HL60_Human1.07439978
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05903099
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.05476438
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.04982371
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.03221801
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03050740
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99530817
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99530817
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99530817
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94622557
91BCL6_27268052_Chip-Seq_Bcells_Human0.93818059
92BCOR_27268052_Chip-Seq_Bcells_Human0.93698376
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92949358
94GATA3_26560356_Chip-Seq_TH2_Human0.91586620
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90515489
96* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88379586
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.85122751
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84949896
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84811703
100E2F7_22180533_ChIP-Seq_HELA_Human0.83518821
101RACK7_27058665_Chip-Seq_MCF-7_Human0.82094306
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81076871
103STAT1_20625510_ChIP-Seq_HELA_Human0.80943413
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80413895
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79469562
106GATA2_19941826_ChIP-Seq_K562_Human0.79306794
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77591881
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77467473
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77292659
110GATA1_19941826_ChIP-Seq_K562_Human0.76155654
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75318396
112NCOR1_26117541_ChIP-Seq_K562_Human0.75190404
113* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74857290
114* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73418070
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73179243
116P300_27268052_Chip-Seq_Bcells_Human0.71514480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.19859864
2MP0003303_peritoneal_inflammation4.06361396
3MP0001835_abnormal_antigen_presentation3.81892831
4MP0009278_abnormal_bone_marrow3.63309775
5MP0009785_altered_susceptibility_to3.54268666
6* MP0002419_abnormal_innate_immunity3.22372255
7MP0002148_abnormal_hypersensitivity_rea3.04959792
8MP0000685_abnormal_immune_system2.97835738
9MP0005000_abnormal_immune_tolerance2.96177952
10MP0003724_increased_susceptibility_to2.86641675
11* MP0005025_abnormal_response_to2.85248216
12MP0006082_CNS_inflammation2.80880098
13MP0005387_immune_system_phenotype2.73011252
14MP0001790_abnormal_immune_system2.73011252
15MP0001800_abnormal_humoral_immune2.61383143
16* MP0002452_abnormal_antigen_presenting2.58050994
17MP0002405_respiratory_system_inflammati2.36926758
18MP0004510_myositis2.36595846
19* MP0002723_abnormal_immune_serum2.34576562
20MP0005058_abnormal_lysosome_morphology2.33947831
21* MP0001819_abnormal_immune_cell2.26003912
22* MP0002420_abnormal_adaptive_immunity2.25222334
23MP0005671_abnormal_response_to2.16142213
24MP0001853_heart_inflammation2.15683014
25MP0005397_hematopoietic_system_phenotyp2.11221455
26MP0001545_abnormal_hematopoietic_system2.11221455
27MP0005464_abnormal_platelet_physiology2.01774719
28MP0001533_abnormal_skeleton_physiology2.01424985
29* MP0001845_abnormal_inflammatory_respons1.87661646
30MP0000343_altered_response_to1.85877147
31MP0003075_altered_response_to1.84713897
32MP0005076_abnormal_cell_differentiation1.76611225
33MP0009764_decreased_sensitivity_to1.74536658
34MP0004947_skin_inflammation1.73831681
35MP0002138_abnormal_hepatobiliary_system1.72541764
36MP0010155_abnormal_intestine_physiology1.68104173
37* MP0000716_abnormal_immune_system1.67174225
38MP0002398_abnormal_bone_marrow1.65880190
39MP0003448_altered_tumor_morphology1.63287770
40MP0002006_tumorigenesis1.61130590
41MP0005451_abnormal_body_composition1.59081415
42MP0003172_abnormal_lysosome_physiology1.54489378
43MP0009333_abnormal_splenocyte_physiolog1.53138298
44MP0003191_abnormal_cellular_cholesterol1.52682287
45MP0000858_altered_metastatic_potential1.49947097
46MP0000689_abnormal_spleen_morphology1.49892164
47MP0003828_pulmonary_edema1.49043202
48MP0008469_abnormal_protein_level1.48192785
49MP0005167_abnormal_blood-brain_barrier1.46878096
50MP0003453_abnormal_keratinocyte_physiol1.43181386
51MP0002933_joint_inflammation1.39270869
52MP0005310_abnormal_salivary_gland1.36183997
53* MP0002429_abnormal_blood_cell1.35620322
54MP0002166_altered_tumor_susceptibility1.34665247
55MP0002722_abnormal_immune_system1.31720748
56MP0008057_abnormal_DNA_replication1.30257667
57MP0003300_gastrointestinal_ulcer1.28141807
58MP0005174_abnormal_tail_pigmentation1.26934765
59MP0001873_stomach_inflammation1.20482581
60MP0004381_abnormal_hair_follicle1.15444139
61MP0001851_eye_inflammation1.13716445
62MP0003183_abnormal_peptide_metabolism1.13588521
63MP0005166_decreased_susceptibility_to1.11922183
64MP0000465_gastrointestinal_hemorrhage1.11603452
65MP0002277_abnormal_respiratory_mucosa1.09229071
66MP0005390_skeleton_phenotype1.03623178
67MP0005164_abnormal_response_to1.01257604
68MP0002998_abnormal_bone_remodeling1.01147984
69MP0009840_abnormal_foam_cell0.99325454
70MP0003656_abnormal_erythrocyte_physiolo0.98127291
71MP0003566_abnormal_cell_adhesion0.97284822
72MP0008004_abnormal_stomach_pH0.94468655
73MP0004883_abnormal_blood_vessel0.91450542
74MP0003763_abnormal_thymus_physiology0.89837714
75MP0003806_abnormal_nucleotide_metabolis0.87641896
76MP0010352_gastrointestinal_tract_polyps0.87442527
77MP0000490_abnormal_crypts_of0.83520238
78MP0000371_diluted_coat_color0.83269598
79MP0005023_abnormal_wound_healing0.82861128
80MP0004808_abnormal_hematopoietic_stem0.80849899
81MP0000604_amyloidosis0.80279917
82MP0009763_increased_sensitivity_to0.79261679
83MP0002132_abnormal_respiratory_system0.76701983
84MP0002396_abnormal_hematopoietic_system0.76404640
85MP0003690_abnormal_glial_cell0.75438676
86MP0002254_reproductive_system_inflammat0.75335631
87MP0000249_abnormal_blood_vessel0.73826911
88MP0000015_abnormal_ear_pigmentation0.72016028
89MP0000703_abnormal_thymus_morphology0.70617045
90MP0003045_fibrosis0.69651936
91MP0009765_abnormal_xenobiotic_induced0.69514226
92MP0003866_abnormal_defecation0.67060584
93MP0005075_abnormal_melanosome_morpholog0.66552918
94MP0008260_abnormal_autophagy0.66461044
95MP0002019_abnormal_tumor_incidence0.65990082
96MP0001663_abnormal_digestive_system0.65339482
97MP0000569_abnormal_digit_pigmentation0.64959832
98MP0000920_abnormal_myelination0.64620614
99MP0001986_abnormal_taste_sensitivity0.64509208
100MP0003091_abnormal_cell_migration0.63809564
101MP0004782_abnormal_surfactant_physiolog0.63582920
102MP0008874_decreased_physiological_sensi0.62915308
103MP0010307_abnormal_tumor_latency0.62178138
104MP0002332_abnormal_exercise_endurance0.60915370
105MP0002009_preneoplasia0.59751533
106MP0001958_emphysema0.59711081
107MP0003279_aneurysm0.56856618
108MP0004130_abnormal_muscle_cell0.56352660
109MP0003221_abnormal_cardiomyocyte_apopto0.55573197
110MP0003638_abnormal_response/metabolism_0.52938141
111MP0003795_abnormal_bone_structure0.51223679
112MP0000609_abnormal_liver_physiology0.51056762
113MP0000767_abnormal_smooth_muscle0.50498790
114MP0005319_abnormal_enzyme/_coenzyme0.50045770
115MP0003329_amyloid_beta_deposits0.49375631
116MP0002133_abnormal_respiratory_system0.47658840
117MP0009115_abnormal_fat_cell0.46949025

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.31309080
2Eczematoid dermatitis (HP:0000976)7.82880686
3Recurrent bacterial skin infections (HP:0005406)7.43447759
4Recurrent gram-negative bacterial infections (HP:0005420)7.36965584
5Mediastinal lymphadenopathy (HP:0100721)5.15173549
6Abnormality of macrophages (HP:0004311)5.10544899
7Chronic obstructive pulmonary disease (HP:0006510)4.91954268
8Obstructive lung disease (HP:0006536)4.91954268
9Pustule (HP:0200039)4.75106009
10Gingivitis (HP:0000230)4.55299376
11Recurrent skin infections (HP:0001581)4.52615363
12Recurrent fungal infections (HP:0002841)4.48979226
13Myositis (HP:0100614)4.21808430
14Stomatitis (HP:0010280)4.11575993
15Systemic lupus erythematosus (HP:0002725)3.82358079
16Elevated erythrocyte sedimentation rate (HP:0003565)3.75628024
17Autoimmune thrombocytopenia (HP:0001973)3.74933300
18Orchitis (HP:0100796)3.73968167
19Cellulitis (HP:0100658)3.58597593
20Urticaria (HP:0001025)3.54492304
21Increased IgM level (HP:0003496)3.52793018
22Vacuolated lymphocytes (HP:0001922)3.52170537
23Spontaneous hematomas (HP:0007420)3.47288929
24Dysostosis multiplex (HP:0000943)3.38085796
25Retrobulbar optic neuritis (HP:0100654)3.35752456
26Optic neuritis (HP:0100653)3.35752456
27Abnormality of glycolipid metabolism (HP:0010969)3.26719751
28Abnormality of liposaccharide metabolism (HP:0010968)3.26719751
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.26719751
30Meningitis (HP:0001287)3.24358081
31Vasculitis (HP:0002633)3.05690258
32T lymphocytopenia (HP:0005403)3.00953714
33Recurrent cutaneous fungal infections (HP:0011370)3.00532446
34Chronic mucocutaneous candidiasis (HP:0002728)3.00532446
35Chest pain (HP:0100749)2.99682870
36Interstitial pulmonary disease (HP:0006530)2.93221355
37Amyloidosis (HP:0011034)2.90543936
38Recurrent viral infections (HP:0004429)2.90383549
39Periodontitis (HP:0000704)2.90375660
40Episodic fever (HP:0001954)2.88784692
41Increased cerebral lipofuscin (HP:0011813)2.84575389
42Urinary glycosaminoglycan excretion (HP:0003541)2.80941242
43Mucopolysacchariduria (HP:0008155)2.80941242
44Colitis (HP:0002583)2.79963942
45Inflammation of the large intestine (HP:0002037)2.70400276
46Hematochezia (HP:0002573)2.64976734
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.64140691
48IgM deficiency (HP:0002850)2.62435213
49Abnormality of polysaccharide metabolism (HP:0011012)2.57595754
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57595754
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57595754
52Gastrointestinal inflammation (HP:0004386)2.55885929
53Recurrent lower respiratory tract infections (HP:0002783)2.55244123
54Hypochromic microcytic anemia (HP:0004840)2.54784384
55Myocardial infarction (HP:0001658)2.54646069
56Cheilitis (HP:0100825)2.53218124
57Recurrent pneumonia (HP:0006532)2.51124456
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.49747975
59Panhypogammaglobulinemia (HP:0003139)2.48873758
60Purpura (HP:0000979)2.39920563
61Granulocytopenia (HP:0001913)2.39699303
62Gangrene (HP:0100758)2.38046280
63Keratoconjunctivitis sicca (HP:0001097)2.36916578
64Glomerulonephritis (HP:0000099)2.35268260
65Increased serum ferritin (HP:0003281)2.34199999
66Hemoptysis (HP:0002105)2.32784329
67Leukocytosis (HP:0001974)2.31269035
68Gingival bleeding (HP:0000225)2.30436037
69Abnormality of the pleura (HP:0002103)2.27490626
70Osteomyelitis (HP:0002754)2.25862235
71Pulmonary infiltrates (HP:0002113)2.20188681
72Nephritis (HP:0000123)2.16108671
73Abnormality of the nasal mucosa (HP:0000433)2.15683705
74Hypergammaglobulinemia (HP:0010702)2.15661214
75Hypochromic anemia (HP:0001931)2.14353181
76Keratoconjunctivitis (HP:0001096)2.13560746
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11804726
78Arterial thrombosis (HP:0004420)2.11696266
79Disinhibition (HP:0000734)2.11319960
80Sepsis (HP:0100806)2.10691053
81Polycythemia (HP:0001901)2.10452974
82Agammaglobulinemia (HP:0004432)2.10312923
83Skin ulcer (HP:0200042)2.09794929
84Abnormality of iron homeostasis (HP:0011031)2.09079830
85Glomerulopathy (HP:0100820)2.08983300
86Abnormality of T cell physiology (HP:0011840)2.08491747
87Vertigo (HP:0002321)2.08287919
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08106578
89Epistaxis (HP:0000421)2.07124182
90Premature loss of primary teeth (HP:0006323)2.05839000
91Anorexia (HP:0002039)2.05827389
92Prostate neoplasm (HP:0100787)2.05692978
93Abnormality of the peritoneum (HP:0002585)2.05185619
94Eosinophilia (HP:0001880)2.04887976
95Hepatosplenomegaly (HP:0001433)2.03029861
96Abnormality of the endocardium (HP:0004306)2.02272838
97Albinism (HP:0001022)2.01327244
98Axonal loss (HP:0003447)2.00980453
99Gastrointestinal stroma tumor (HP:0100723)2.00519784
100Spondylolisthesis (HP:0003302)2.00518782
101Polyneuropathy (HP:0001271)1.99985205
102Abnormal platelet volume (HP:0011876)1.99481673
103Gastrointestinal infarctions (HP:0005244)1.99098411
104Abnormality of T cells (HP:0002843)1.95847282
105Prolonged bleeding time (HP:0003010)1.93827549
106Pulmonary embolism (HP:0002204)1.93827363
107Encephalitis (HP:0002383)1.92947873
108Keratitis (HP:0000491)1.92664077
109Joint hemorrhage (HP:0005261)1.92615801
110Slow saccadic eye movements (HP:0000514)1.91862107
111Chronic otitis media (HP:0000389)1.91669019
112Microcytic anemia (HP:0001935)1.91419868
113Abnormality of T cell number (HP:0011839)1.91012527
114Acne (HP:0001061)1.90456136
115Petechiae (HP:0000967)1.90022835
116Amaurosis fugax (HP:0100576)1.89332803
117IgA deficiency (HP:0002720)1.88794149
118Loss of speech (HP:0002371)1.85764333
119Nasal polyposis (HP:0100582)1.84100628
120Peritonitis (HP:0002586)1.82328943
121Increased IgE level (HP:0003212)1.81815466
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.81055971
123Lower limb hyperreflexia (HP:0002395)1.79763210
124Basal ganglia calcification (HP:0002135)1.79052191
125Abnormality of complement system (HP:0005339)1.77599036
126Thick nail (HP:0001805)1.75549396
127Restrictive lung disease (HP:0002091)1.74092428
128Agnosia (HP:0010524)1.72975556
129Recurrent sinusitis (HP:0011108)1.72485912
130Lymphopenia (HP:0001888)1.70323457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.46797649
2MAP4K13.93696386
3RIPK43.84011606
4IRAK43.62346062
5MAP3K142.85770319
6* CSK2.62924740
7PRPF4B2.60144381
8TYK22.46988458
9MATK2.38132287
10ERN12.28547338
11TBK12.26561524
12STK102.15524316
13IRAK32.08829867
14MAP3K112.00777267
15EPHB11.96120089
16TAOK11.79116716
17MAP3K61.74551089
18CLK11.70681842
19TRPM71.68846388
20IKBKB1.67529003
21TXK1.62281614
22BTK1.61901240
23ZAP701.56878141
24HCK1.54970167
25ICK1.54323485
26BMX1.50714562
27PIM11.47591603
28PIM21.40688556
29JAK31.37157193
30FES1.35622119
31IKBKE1.35360188
32SIK31.32571943
33MAPK151.32472489
34LYN1.31867173
35CSF1R1.30597116
36GRK61.30328874
37YES11.29540828
38JAK11.27979857
39TEC1.27448931
40KIT1.26658242
41MAP3K11.21454066
42SYK1.17451968
43TGFBR21.16043747
44KSR21.15894901
45DDR21.11598435
46* FGR1.10463484
47LRRK21.05046355
48LCK1.02885071
49MAP2K31.02269846
50MAP3K131.00830451
51CHUK0.98641068
52JAK20.98048360
53IRAK20.96276204
54MARK20.94824404
55TRIB30.93855447
56IRAK10.93166624
57DAPK10.92918763
58RPS6KA60.91552672
59RPS6KC10.90218168
60RPS6KL10.90218168
61PDPK10.85539579
62MARK30.84551045
63RIPK10.84097142
64ITK0.82201574
65ERBB30.79476019
66CDC42BPA0.78884542
67MAPK120.76422651
68TESK20.73896201
69RPS6KA40.73330157
70CDK60.73120452
71SIK20.71722922
72EGFR0.71094004
73MAPK70.70882418
74PRKCD0.70780197
75MAPKAPK20.68295192
76CDK190.68106329
77DYRK1B0.65140214
78MAP3K70.62202276
79ABL10.61220585
80* FYN0.61109551
81MAPK110.59688428
82MAPK40.59494054
83KDR0.57064205
84MAP3K120.54778732
85TAOK30.54702166
86PRKD20.54641603
87FGFR40.54601876
88SGK30.54096386
89PIK3CG0.53598511
90FGFR30.52856664
91GRK70.52820136
92MAP3K20.52040115
93RPS6KA10.51833494
94MAP2K40.50667656
95GSK3A0.50448865
96CAMKK10.49752570
97MST40.48658102
98PTK60.48591886
99TTN0.48195584
100MOS0.48082533
101STK110.47325842
102TAOK20.47284086
103SMG10.47050653
104ALK0.45853774
105TYRO30.45768584
106CDK70.45695186
107STK40.44724497
108SIK10.44173351
109PTK2B0.43823756
110MAP3K100.43591419
111HIPK20.43452076
112PAK40.41949361
113BMPR20.41443310
114PTK20.40013827
115CDK120.39797387
116CAMKK20.39534298
117MAP3K50.39146878
118DAPK20.39089294
119MAP3K30.38815122
120ABL20.37480183
121RET0.37148384
122TNK20.37053530
123MAP2K60.35415145
124MAP3K80.35406068
125EPHA30.34997593
126RAF10.34779927
127KSR10.34518231
128PRKG20.33921023
129SGK20.31809924
130CAMK1D0.30457830
131PRKCQ0.30444816
132DMPK0.29947570
133PDK10.28069206
134PRKCH0.27791589
135NEK90.27549393

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.96502564
2Leishmaniasis_Homo sapiens_hsa051403.81586113
3Graft-versus-host disease_Homo sapiens_hsa053322.63357181
4Osteoclast differentiation_Homo sapiens_hsa043802.57761343
5Legionellosis_Homo sapiens_hsa051342.54118003
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.43718644
7Tuberculosis_Homo sapiens_hsa051522.36868899
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33310476
9Pertussis_Homo sapiens_hsa051332.24695832
10B cell receptor signaling pathway_Homo sapiens_hsa046622.08880191
11Shigellosis_Homo sapiens_hsa051312.01817546
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99602548
13Salmonella infection_Homo sapiens_hsa051321.93045931
14Malaria_Homo sapiens_hsa051441.92833295
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88754872
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88320338
17Measles_Homo sapiens_hsa051621.86199922
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84844443
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78582854
20Hematopoietic cell lineage_Homo sapiens_hsa046401.77985823
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76521021
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.72122062
23TNF signaling pathway_Homo sapiens_hsa046681.69759920
24* Chemokine signaling pathway_Homo sapiens_hsa040621.63345424
25Asthma_Homo sapiens_hsa053101.61148781
26Rheumatoid arthritis_Homo sapiens_hsa053231.60422240
27Lysosome_Homo sapiens_hsa041421.57814106
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.54910573
29Allograft rejection_Homo sapiens_hsa053301.54820247
30Phagosome_Homo sapiens_hsa041451.52311283
31Herpes simplex infection_Homo sapiens_hsa051681.45699575
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44387495
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42542861
34Influenza A_Homo sapiens_hsa051641.39754251
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.39699334
36Primary immunodeficiency_Homo sapiens_hsa053401.36965205
37Toxoplasmosis_Homo sapiens_hsa051451.34676360
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.33692600
39Other glycan degradation_Homo sapiens_hsa005111.29337993
40Viral myocarditis_Homo sapiens_hsa054161.28364462
41African trypanosomiasis_Homo sapiens_hsa051431.28059703
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27864400
43Apoptosis_Homo sapiens_hsa042101.23227078
44Type I diabetes mellitus_Homo sapiens_hsa049401.21146406
45Hepatitis B_Homo sapiens_hsa051611.18434818
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05108072
47Acute myeloid leukemia_Homo sapiens_hsa052211.04250793
48Antigen processing and presentation_Homo sapiens_hsa046121.04249106
49Non-small cell lung cancer_Homo sapiens_hsa052231.04107742
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01484635
51Complement and coagulation cascades_Homo sapiens_hsa046100.98302681
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88968015
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88901524
54T cell receptor signaling pathway_Homo sapiens_hsa046600.85396432
55Amoebiasis_Homo sapiens_hsa051460.82735889
56Fatty acid biosynthesis_Homo sapiens_hsa000610.82623434
57Hepatitis C_Homo sapiens_hsa051600.81631365
58Platelet activation_Homo sapiens_hsa046110.81539639
59Pancreatic cancer_Homo sapiens_hsa052120.80862855
60Caffeine metabolism_Homo sapiens_hsa002320.77318144
61VEGF signaling pathway_Homo sapiens_hsa043700.76869196
62Renal cell carcinoma_Homo sapiens_hsa052110.76110183
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76088779
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75266312
65Notch signaling pathway_Homo sapiens_hsa043300.74670131
66Chronic myeloid leukemia_Homo sapiens_hsa052200.74057963
67Base excision repair_Homo sapiens_hsa034100.72737180
68Adherens junction_Homo sapiens_hsa045200.71293014
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69802307
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69338558
71Autoimmune thyroid disease_Homo sapiens_hsa053200.68821163
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.66435976
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63415593
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62233881
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.62006036
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60692422
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60535248
78GnRH signaling pathway_Homo sapiens_hsa049120.56424625
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.55542248
80p53 signaling pathway_Homo sapiens_hsa041150.55515008
81* Epstein-Barr virus infection_Homo sapiens_hsa051690.53277594
82Type II diabetes mellitus_Homo sapiens_hsa049300.51473912
83Choline metabolism in cancer_Homo sapiens_hsa052310.50684834
84mTOR signaling pathway_Homo sapiens_hsa041500.50523401
85Endometrial cancer_Homo sapiens_hsa052130.49024283
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49000172
87Endocytosis_Homo sapiens_hsa041440.48028138
88Dorso-ventral axis formation_Homo sapiens_hsa043200.47578228
89Viral carcinogenesis_Homo sapiens_hsa052030.47319947
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45623650
91Bladder cancer_Homo sapiens_hsa052190.44466762
92Collecting duct acid secretion_Homo sapiens_hsa049660.44403149
93Prolactin signaling pathway_Homo sapiens_hsa049170.40850107
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39603523
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38242441
96Proteoglycans in cancer_Homo sapiens_hsa052050.38048294
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37558657
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37445997
99Inositol phosphate metabolism_Homo sapiens_hsa005620.36607815
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.36320864
101Prion diseases_Homo sapiens_hsa050200.35506278
102MAPK signaling pathway_Homo sapiens_hsa040100.34510872
103Insulin resistance_Homo sapiens_hsa049310.33788944
104Small cell lung cancer_Homo sapiens_hsa052220.32547172
105Regulation of autophagy_Homo sapiens_hsa041400.32405735
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31442737
107ErbB signaling pathway_Homo sapiens_hsa040120.31313317
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29735907
109HIF-1 signaling pathway_Homo sapiens_hsa040660.29550499
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.28534754
111HTLV-I infection_Homo sapiens_hsa051660.27490000
112MicroRNAs in cancer_Homo sapiens_hsa052060.26890087
113Colorectal cancer_Homo sapiens_hsa052100.26755640
114FoxO signaling pathway_Homo sapiens_hsa040680.25581288
115Pentose phosphate pathway_Homo sapiens_hsa000300.20888944
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18369082
117Rap1 signaling pathway_Homo sapiens_hsa040150.17586425
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17002993
119Mismatch repair_Homo sapiens_hsa034300.15837441

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