FGFRL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.35130842
2low-density lipoprotein particle clearance (GO:0034383)5.16839021
3positive regulation of fatty acid beta-oxidation (GO:0032000)5.07402456
4Golgi transport vesicle coating (GO:0048200)4.81355833
5COPI coating of Golgi vesicle (GO:0048205)4.81355833
6positive regulation of fatty acid oxidation (GO:0046321)4.61764461
7regulation of sequestering of triglyceride (GO:0010889)4.55828475
8triglyceride catabolic process (GO:0019433)4.32510816
9biotin metabolic process (GO:0006768)4.21290397
10regulation of fatty acid beta-oxidation (GO:0031998)4.18605525
11sulfur amino acid catabolic process (GO:0000098)4.13609007
12acylglycerol catabolic process (GO:0046464)4.09724467
13neutral lipid catabolic process (GO:0046461)4.09724467
14valine metabolic process (GO:0006573)4.08803093
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04271897
16basement membrane organization (GO:0071711)4.04151073
17fatty acid beta-oxidation (GO:0006635)3.99344117
18L-phenylalanine catabolic process (GO:0006559)3.97468094
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.97468094
20L-phenylalanine metabolic process (GO:0006558)3.91595050
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91595050
22plasma lipoprotein particle clearance (GO:0034381)3.88320821
23fatty acid transmembrane transport (GO:1902001)3.85106070
24protein retention in ER lumen (GO:0006621)3.84793058
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.84031333
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.81587691
27acetyl-CoA metabolic process (GO:0006084)3.73274878
28white fat cell differentiation (GO:0050872)3.71782624
29regulation of fatty acid oxidation (GO:0046320)3.71241548
30adherens junction assembly (GO:0034333)3.71226318
31negative regulation of fatty acid transport (GO:2000192)3.70741207
32positive regulation of lipid catabolic process (GO:0050996)3.70130549
33hemidesmosome assembly (GO:0031581)3.68768936
34fatty acid oxidation (GO:0019395)3.66474889
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.65120560
36regulation of triglyceride catabolic process (GO:0010896)3.65073433
37cell-substrate junction assembly (GO:0007044)3.64323886
38protein localization to endosome (GO:0036010)3.63269666
39lipid oxidation (GO:0034440)3.62645671
40semaphorin-plexin signaling pathway (GO:0071526)3.58570293
41fatty acid catabolic process (GO:0009062)3.56482422
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56247713
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56036272
44fatty-acyl-CoA biosynthetic process (GO:0046949)3.54788257
45carnitine shuttle (GO:0006853)3.51917658
46cell-substrate adherens junction assembly (GO:0007045)3.51784377
47focal adhesion assembly (GO:0048041)3.51784377
48epithelial cell-cell adhesion (GO:0090136)3.50545783
49protein heterotrimerization (GO:0070208)3.50011235
50triglyceride biosynthetic process (GO:0019432)3.48551388
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47726078
52thioester biosynthetic process (GO:0035384)3.46115188
53acyl-CoA biosynthetic process (GO:0071616)3.46115188
54proline biosynthetic process (GO:0006561)3.43336203
55positive regulation of fatty acid metabolic process (GO:0045923)3.42242810
56acylglycerol biosynthetic process (GO:0046463)3.40780250
57neutral lipid biosynthetic process (GO:0046460)3.40780250
58skin morphogenesis (GO:0043589)3.40524082
59regulation of glucose import in response to insulin stimulus (GO:2001273)3.37609951
60acylglycerol homeostasis (GO:0055090)3.35697140
61triglyceride homeostasis (GO:0070328)3.35697140
62lysine catabolic process (GO:0006554)3.34062507
63lysine metabolic process (GO:0006553)3.34062507
64complement activation, alternative pathway (GO:0006957)3.31396310
65branched-chain amino acid catabolic process (GO:0009083)3.30915549
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.30574298
67triglyceride metabolic process (GO:0006641)3.27931910
68regulation of cholesterol storage (GO:0010885)3.27848574
69negative regulation of cell size (GO:0045792)3.27736290
70brown fat cell differentiation (GO:0050873)3.26638387
71fatty-acyl-CoA metabolic process (GO:0035337)3.25372319
72positive regulation of triglyceride metabolic process (GO:0090208)3.24165217
73epoxygenase P450 pathway (GO:0019373)3.22428526
74branched-chain amino acid metabolic process (GO:0009081)3.21004254
75activation of Rac GTPase activity (GO:0032863)3.20971335
76monocarboxylic acid catabolic process (GO:0072329)3.18762779
77insulin-like growth factor receptor signaling pathway (GO:0048009)3.17465026
78regulation of early endosome to late endosome transport (GO:2000641)3.17461101
79glyoxylate metabolic process (GO:0046487)3.11723244
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09898221
81amino-acid betaine metabolic process (GO:0006577)3.09815364
82vascular endothelial growth factor signaling pathway (GO:0038084)3.09474006
83acylglycerol metabolic process (GO:0006639)3.08451417
84vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.06212141
85short-chain fatty acid metabolic process (GO:0046459)3.04805980
86endothelial cell morphogenesis (GO:0001886)3.04469109
87cysteine metabolic process (GO:0006534)3.03966388
88desmosome organization (GO:0002934)3.03597613
89neutral lipid metabolic process (GO:0006638)3.02589243
90regulation of cholesterol homeostasis (GO:2000188)3.01260254
91endothelial cell chemotaxis (GO:0035767)3.00490577
92cellular glucuronidation (GO:0052695)2.98640016
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97777690
94regulation of triglyceride metabolic process (GO:0090207)2.97082719
95carnitine transmembrane transport (GO:1902603)2.95449057
96regulation of cholesterol metabolic process (GO:0090181)2.95322119
97lipid particle organization (GO:0034389)2.95183573
98negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.94374197
99aromatic amino acid family catabolic process (GO:0009074)2.93072202
1002-oxoglutarate metabolic process (GO:0006103)2.92830989
101carnitine metabolic process (GO:0009437)2.92394262
102very long-chain fatty acid metabolic process (GO:0000038)2.92051420
103coenzyme catabolic process (GO:0009109)2.91563169
104long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.91560027
105glycerolipid catabolic process (GO:0046503)2.89730281
106ethanol oxidation (GO:0006069)2.88983053
107positive regulation of glycogen biosynthetic process (GO:0045725)2.88119785
108negative regulation of fibrinolysis (GO:0051918)2.87996196
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87842030
110endodermal cell differentiation (GO:0035987)2.87164222
111regulation of triglyceride biosynthetic process (GO:0010866)2.86989488
112negative regulation of lipase activity (GO:0060192)2.86201351
113protein carboxylation (GO:0018214)2.86164423
114peptidyl-glutamic acid carboxylation (GO:0017187)2.86164423
115linoleic acid metabolic process (GO:0043651)2.85910395
116bile acid biosynthetic process (GO:0006699)2.85499593
117fatty acid homeostasis (GO:0055089)2.85338112
118cell adhesion mediated by integrin (GO:0033627)2.84866550
119amino-acid betaine transport (GO:0015838)2.83877895
120carnitine transport (GO:0015879)2.83877895
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83066365
122tricarboxylic acid metabolic process (GO:0072350)2.82831442
123thioester metabolic process (GO:0035383)2.82670981
124acyl-CoA metabolic process (GO:0006637)2.82670981
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81533545
126type B pancreatic cell proliferation (GO:0044342)2.80737899
127cellular response to cholesterol (GO:0071397)2.78173753
128regulation of plasminogen activation (GO:0010755)2.77856224
129regulation of cholesterol biosynthetic process (GO:0045540)2.77680807
130chondrocyte proliferation (GO:0035988)2.76653011
131atrioventricular valve morphogenesis (GO:0003181)2.74604234
132positive regulation of triglyceride biosynthetic process (GO:0010867)2.74573668
133branching involved in mammary gland duct morphogenesis (GO:0060444)2.73055905
134apoptotic process involved in morphogenesis (GO:0060561)2.72373698
135collagen fibril organization (GO:0030199)2.72266109
136stress fiber assembly (GO:0043149)2.70834858
137regulation of protein activation cascade (GO:2000257)2.69429850
138maternal placenta development (GO:0001893)2.67547229
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67448746
140organic acid catabolic process (GO:0016054)2.66988564
141carboxylic acid catabolic process (GO:0046395)2.66988564
142barbed-end actin filament capping (GO:0051016)2.65574918
143negative regulation of chondrocyte differentiation (GO:0032331)2.65268979
144negative regulation of catenin import into nucleus (GO:0035414)2.65210008
145aspartate family amino acid catabolic process (GO:0009068)2.64744671
146cellular modified amino acid catabolic process (GO:0042219)2.64510437
147mesodermal cell differentiation (GO:0048333)2.64251141
148cochlea morphogenesis (GO:0090103)2.63702325
149positive regulation of osteoblast proliferation (GO:0033690)2.62859152
150cell-cell junction maintenance (GO:0045217)2.59362115
151proline metabolic process (GO:0006560)2.59225831
152regulation of extracellular matrix disassembly (GO:0010715)2.57262887
153regulation of establishment of planar polarity (GO:0090175)2.55605786
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52887674
155protein maturation by protein folding (GO:0022417)2.52201104
156regulation of endothelial cell chemotaxis (GO:2001026)2.49787049
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.47187547
158glucose catabolic process (GO:0006007)2.47042460
159substrate-dependent cell migration (GO:0006929)2.44433237
160positive regulation of extracellular matrix organization (GO:1903055)2.42906249
161muscle cell migration (GO:0014812)2.42130538
162regulation of translational fidelity (GO:0006450)2.41701849
163blood vessel endothelial cell migration (GO:0043534)2.40500227
164positive regulation of nuclease activity (GO:0032075)2.39669808
165regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.39301051
166retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37599947
167cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.37326575
168convergent extension (GO:0060026)2.35690708
169protein targeting to plasma membrane (GO:0072661)2.34505433
170embryonic eye morphogenesis (GO:0048048)2.30732902
171protein localization to microtubule (GO:0035372)2.30647616
172vesicle coating (GO:0006901)2.30269959
173embryo implantation (GO:0007566)2.29178377
174positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28594331
175positive regulation of histone deacetylation (GO:0031065)2.28299918
176branching involved in salivary gland morphogenesis (GO:0060445)2.27567224
177regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.26810664
178positive regulation of receptor recycling (GO:0001921)2.26370065
179apoptotic cell clearance (GO:0043277)2.26300603
180membrane protein ectodomain proteolysis (GO:0006509)2.26092468
181modulation by virus of host morphology or physiology (GO:0019048)2.25386802
182pentose-phosphate shunt (GO:0006098)2.24243107
183negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23922979
184cellular protein complex localization (GO:0034629)2.22825876
185regulation of NFAT protein import into nucleus (GO:0051532)2.22656198
186glial cell migration (GO:0008347)2.22550975
187positive regulation of astrocyte differentiation (GO:0048711)2.21770865
188hypotonic response (GO:0006971)2.21339908
189extracellular matrix disassembly (GO:0022617)2.20649854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.40101856
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.20891339
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.63218358
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01018959
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.98343656
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.86948949
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.80923570
8CLOCK_20551151_ChIP-Seq_293T_Human3.68455000
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.27969352
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00108074
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.77748045
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64768962
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26060336
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17166989
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11050589
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.02577001
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02048555
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96599904
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85926641
20VDR_21846776_ChIP-Seq_THP-1_Human1.84413459
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71792798
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70619334
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69426891
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68438105
25TCF7_22412390_ChIP-Seq_EML_Mouse1.65053414
26MYC_22102868_ChIP-Seq_BL_Human1.64947243
27ZNF263_19887448_ChIP-Seq_K562_Human1.64448502
28* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63843241
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61999930
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54693864
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52297866
32AR_21909140_ChIP-Seq_LNCAP_Human1.52073610
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.51731487
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51194787
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50692426
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47946221
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43391671
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.39868769
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39429700
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39102103
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39001557
42* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38760560
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38637261
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38616876
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.38185898
46UBF1/2_26484160_Chip-Seq_HMECs_Human1.37385456
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.35706714
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35610062
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.34630760
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34115966
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32269763
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.31420614
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.31420614
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30111701
55PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.29633199
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.27816185
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.27038733
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26590807
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25234649
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.24133643
61P68_20966046_ChIP-Seq_HELA_Human1.21543624
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21458054
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21105217
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.19754333
65* LXR_22292898_ChIP-Seq_THP-1_Human1.19573134
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16580316
67SMC4_20622854_ChIP-Seq_HELA_Human1.16152960
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15075705
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13726175
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.13203800
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.12954445
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12249289
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11776552
74PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11194581
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11090114
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11078094
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10814331
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10674380
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09714745
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07906293
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07700207
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07502215
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07348376
84* CJUN_26792858_Chip-Seq_BT549_Human1.07343991
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05920230
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05920230
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05160183
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05004912
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04431823
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04146826
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04127246
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03804444
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02965157
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02722012
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02395020
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02395020
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01665639
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01557207
99* ERG_21242973_ChIP-ChIP_JURKAT_Human1.01533264
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01341983
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99124956
102CHD1_26751641_Chip-Seq_LNCaP_Human0.97723809
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97595035
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.96536636
105* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94572017
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94236726
107* KDM2B_26808549_Chip-Seq_K562_Human0.93867144
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93208019
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92191686
110EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91696292
111RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91696292
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88771281
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87635090
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85662168
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85444995
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84960254
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84321160
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83189161
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.82511066
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.82279951
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81743989
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81735328
123ATF3_27146783_Chip-Seq_COLON_Human0.81553191
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81386100
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.80403478
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79951848
127TP53_22127205_ChIP-Seq_IMR90_Human0.79939208
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79813392
129KDM2B_26808549_Chip-Seq_DND41_Human0.78857419
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78757495
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78587066
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.78484762
133SOX2_20726797_ChIP-Seq_SW620_Human0.78348348
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78066408
135* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77739881
136GATA1_19941826_ChIP-Seq_K562_Human0.77551261
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76556718
138GATA4_25053715_ChIP-Seq_YYC3_Human0.76528273
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.76001631
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.75711779
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75102236
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74170035
143CREB1_26743006_Chip-Seq_LNCaP_Human0.73021105
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72931719
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.72729070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.90735008
2MP0005670_abnormal_white_adipose4.27554741
3MP0002139_abnormal_hepatobiliary_system4.02128564
4MP0003705_abnormal_hypodermis_morpholog3.41243600
5MP0005360_urolithiasis3.32007531
6MP0005666_abnormal_adipose_tissue3.25973826
7MP0004130_abnormal_muscle_cell3.02770109
8MP0005365_abnormal_bile_salt3.01610335
9MP0004185_abnormal_adipocyte_glucose2.89285477
10MP0010329_abnormal_lipoprotein_level2.79860274
11MP0005275_abnormal_skin_tensile2.75895300
12MP0005451_abnormal_body_composition2.64357681
13MP0005085_abnormal_gallbladder_physiolo2.53465573
14MP0005375_adipose_tissue_phenotype2.41529864
15MP0005076_abnormal_cell_differentiation2.34865957
16MP0005257_abnormal_intraocular_pressure2.29876426
17MP0004233_abnormal_muscle_weight2.25913234
18MP0000537_abnormal_urethra_morphology2.16598194
19MP0004272_abnormal_basement_membrane2.14315813
20MP0002877_abnormal_melanocyte_morpholog2.11653926
21MP0002971_abnormal_brown_adipose2.08200348
22MP0003806_abnormal_nucleotide_metabolis2.05268071
23MP0005503_abnormal_tendon_morphology1.89880561
24MP0002118_abnormal_lipid_homeostasis1.89100493
25MP0009840_abnormal_foam_cell1.85705137
26MP0005058_abnormal_lysosome_morphology1.85000442
27MP0010234_abnormal_vibrissa_follicle1.80864596
28MP0000566_synostosis1.78668961
29MP0003252_abnormal_bile_duct1.78007425
30MP0003091_abnormal_cell_migration1.77623169
31MP0002837_dystrophic_cardiac_calcinosis1.75878285
32MP0000003_abnormal_adipose_tissue1.72173871
33MP0008875_abnormal_xenobiotic_pharmacok1.67054571
34MP0003191_abnormal_cellular_cholesterol1.63714478
35MP0003690_abnormal_glial_cell1.55184732
36MP0009115_abnormal_fat_cell1.55101914
37MP0003279_aneurysm1.54739789
38MP0005332_abnormal_amino_acid1.52796431
39MP0000534_abnormal_ureter_morphology1.52320178
40MP0003453_abnormal_keratinocyte_physiol1.51999127
41MP0000013_abnormal_adipose_tissue1.48158860
42MP0005409_darkened_coat_color1.47315312
43MP0009384_cardiac_valve_regurgitation1.44078704
44MP0001348_abnormal_lacrimal_gland1.41623046
45MP0000609_abnormal_liver_physiology1.40912375
46MP0003123_paternal_imprinting1.39185726
47MP0001958_emphysema1.37285722
48MP0005334_abnormal_fat_pad1.37133650
49MP0000751_myopathy1.36478514
50MP0000678_abnormal_parathyroid_gland1.35436662
51MP0002108_abnormal_muscle_morphology1.31295034
52MP0000767_abnormal_smooth_muscle1.30335411
53MP0002060_abnormal_skin_morphology1.26927696
54MP0003186_abnormal_redox_activity1.17726468
55MP0009780_abnormal_chondrocyte_physiolo1.17481926
56MP0004087_abnormal_muscle_fiber1.16809032
57MP0005083_abnormal_biliary_tract1.14864035
58MP0001666_abnormal_nutrient_absorption1.13992660
59MP0002970_abnormal_white_adipose1.11237998
60MP0010352_gastrointestinal_tract_polyps1.10409464
61MP0005501_abnormal_skin_physiology1.09500807
62MP0002295_abnormal_pulmonary_circulatio1.08314537
63MP0001661_extended_life_span1.08214158
64* MP0003942_abnormal_urinary_system1.08157940
65MP0005584_abnormal_enzyme/coenzyme_acti1.06524083
66MP0005623_abnormal_meninges_morphology1.06416269
67MP0003283_abnormal_digestive_organ1.06336709
68MP0010368_abnormal_lymphatic_system1.06159604
69MP0002796_impaired_skin_barrier1.05514647
70MP0000467_abnormal_esophagus_morphology1.03591783
71MP0005319_abnormal_enzyme/_coenzyme1.03524963
72MP0003878_abnormal_ear_physiology1.03431590
73MP0005377_hearing/vestibular/ear_phenot1.03431590
74MP0008260_abnormal_autophagy1.03174391
75MP0000749_muscle_degeneration1.02830211
76MP0006138_congestive_heart_failure1.02588393
77MP0000858_altered_metastatic_potential1.01268684
78MP0010030_abnormal_orbit_morphology0.99263354
79MP0000750_abnormal_muscle_regeneration0.98373802
80MP0003950_abnormal_plasma_membrane0.97687198
81MP0002254_reproductive_system_inflammat0.96095132
82MP0001915_intracranial_hemorrhage0.95253073
83MP0002282_abnormal_trachea_morphology0.94780167
84MP0003566_abnormal_cell_adhesion0.94603537
85* MP0000163_abnormal_cartilage_morphology0.94496963
86MP0009053_abnormal_anal_canal0.94389705
87MP0003959_abnormal_lean_body0.93571982
88* MP0000759_abnormal_skeletal_muscle0.93206710
89MP0003385_abnormal_body_wall0.90639507
90* MP0005508_abnormal_skeleton_morphology0.87741875
91MP0003315_abnormal_perineum_morphology0.87726295
92MP0003195_calcinosis0.86833020
93MP0005330_cardiomyopathy0.85891003
94* MP0009250_abnormal_appendicular_skeleto0.85590171
95* MP0000733_abnormal_muscle_development0.85095350
96MP0002697_abnormal_eye_size0.83950992
97MP0002089_abnormal_postnatal_growth/wei0.83584022
98* MP0004134_abnormal_chest_morphology0.82335507
99MP0003011_delayed_dark_adaptation0.81601626
100MP0009672_abnormal_birth_weight0.81094123
101MP0000747_muscle_weakness0.80839373
102MP0002896_abnormal_bone_mineralization0.80832422
103MP0000462_abnormal_digestive_system0.80279476
104MP0001299_abnormal_eye_distance/0.79743525
105MP0003115_abnormal_respiratory_system0.79399742
106MP0004019_abnormal_vitamin_homeostasis0.78394461
107MP0005621_abnormal_cell_physiology0.77268077
108* MP0002115_abnormal_skeleton_extremities0.76788521
109MP0005595_abnormal_vascular_smooth0.76318254
110MP0002168_other_aberrant_phenotype0.75848066
111MP0002269_muscular_atrophy0.75158507
112MP0005248_abnormal_Harderian_gland0.74962231
113MP0002932_abnormal_joint_morphology0.74795726
114MP0005448_abnormal_energy_balance0.74586269
115MP0003941_abnormal_skin_development0.74499787
116MP0005023_abnormal_wound_healing0.74157305
117MP0001730_embryonic_growth_arrest0.73826340
118MP0005620_abnormal_muscle_contractility0.73445085
119MP0000762_abnormal_tongue_morphology0.72647236
120MP0009643_abnormal_urine_homeostasis0.72467139
121* MP0001614_abnormal_blood_vessel0.71789797
122MP0004264_abnormal_extraembryonic_tissu0.71626032
123MP0003656_abnormal_erythrocyte_physiolo0.71478953
124MP0004510_myositis0.71437963
125MP0004858_abnormal_nervous_system0.70490120
126MP0010630_abnormal_cardiac_muscle0.70215804
127MP0003329_amyloid_beta_deposits0.69952981
128MP0005535_abnormal_body_temperature0.69906797
129MP0001849_ear_inflammation0.69856439
130MP0005164_abnormal_response_to0.69611372
131MP0005385_cardiovascular_system_phenoty0.69558780
132MP0001544_abnormal_cardiovascular_syste0.69558780
133MP0008775_abnormal_heart_ventricle0.68700714
134* MP0002116_abnormal_craniofacial_bone0.68220268
135* MP0002113_abnormal_skeleton_development0.68065424
136* MP0002925_abnormal_cardiovascular_devel0.67488397
137MP0000627_abnormal_mammary_gland0.67388270
138* MP0000432_abnormal_head_morphology0.67281121
139MP0003634_abnormal_glial_cell0.66571604
140MP0000428_abnormal_craniofacial_morphol0.65982155
141MP0002092_abnormal_eye_morphology0.65897410
142MP0001216_abnormal_epidermal_layer0.65855573
143* MP0002249_abnormal_larynx_morphology0.65487427
144MP0002078_abnormal_glucose_homeostasis0.65369363
145MP0005369_muscle_phenotype0.65199219
146MP0010771_integument_phenotype0.64859185
147* MP0002114_abnormal_axial_skeleton0.64740629

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.04002670
2Premature rupture of membranes (HP:0001788)3.88275792
3Xanthomatosis (HP:0000991)3.84060450
4Type 1 muscle fiber predominance (HP:0003803)3.70836884
5Deep venous thrombosis (HP:0002625)3.62730313
6Hyperglycinuria (HP:0003108)3.51838414
7Broad metatarsal (HP:0001783)3.49356722
8Hyperlipoproteinemia (HP:0010980)3.43160018
9Hyperacusis (HP:0010780)3.37798238
10Abnormality of serine family amino acid metabolism (HP:0010894)3.37022138
11Abnormality of glycine metabolism (HP:0010895)3.37022138
12Hypoalphalipoproteinemia (HP:0003233)3.23447479
13Ulnar bowing (HP:0003031)3.13658496
14Acanthosis nigricans (HP:0000956)3.03107401
15Ankle contracture (HP:0006466)3.01767100
16Vertebral compression fractures (HP:0002953)2.98617443
17Shallow orbits (HP:0000586)2.96963242
18Ketosis (HP:0001946)2.96562761
19Broad face (HP:0000283)2.92921128
20Epidermoid cyst (HP:0200040)2.92772767
21Hypoplastic ischia (HP:0003175)2.92065436
22Intrahepatic cholestasis (HP:0001406)2.91278450
23Hyperammonemia (HP:0001987)2.90451364
24Complement deficiency (HP:0004431)2.88322856
25Obstructive sleep apnea (HP:0002870)2.86251059
26Turricephaly (HP:0000262)2.78826134
27Myoglobinuria (HP:0002913)2.78691461
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.75892960
29Short nail (HP:0001799)2.73757923
30Increased connective tissue (HP:0009025)2.70777261
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70675625
32Hypoglycemic coma (HP:0001325)2.67626935
33Difficulty running (HP:0009046)2.67325295
34Upper limb amyotrophy (HP:0009129)2.67172304
35Distal upper limb amyotrophy (HP:0007149)2.67172304
36Hypertriglyceridemia (HP:0002155)2.66994578
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62751450
38Abnormality of the ischium (HP:0003174)2.62085763
39Distal lower limb amyotrophy (HP:0008944)2.59777158
40Abnormality of fatty-acid metabolism (HP:0004359)2.59458236
41Hypolipoproteinemia (HP:0010981)2.56869581
42Spinal rigidity (HP:0003306)2.55964632
43Ketoacidosis (HP:0001993)2.53138000
44Trismus (HP:0000211)2.52279461
45Increased variability in muscle fiber diameter (HP:0003557)2.51650002
46Myocardial infarction (HP:0001658)2.51574394
47Hyperglycinemia (HP:0002154)2.46205670
48Arterial tortuosity (HP:0005116)2.46111798
49Achilles tendon contracture (HP:0001771)2.45691979
50Abnormal cartilage morphology (HP:0002763)2.44718978
51Epiphyseal dysplasia (HP:0002656)2.41822013
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39372828
53Aortic dissection (HP:0002647)2.38389880
54Muscle fiber splitting (HP:0003555)2.38339804
55Vascular tortuosity (HP:0004948)2.38302654
56Biconcave vertebral bodies (HP:0004586)2.38257746
57Oligomenorrhea (HP:0000876)2.38192639
58Distal lower limb muscle weakness (HP:0009053)2.34986194
59Hydroxyprolinuria (HP:0003080)2.34978784
60Abnormality of proline metabolism (HP:0010907)2.34978784
61Disproportionate tall stature (HP:0001519)2.33658350
62Neonatal short-limb short stature (HP:0008921)2.33520885
63Coronal craniosynostosis (HP:0004440)2.32103757
64Wormian bones (HP:0002645)2.30889822
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30153299
66Slender build (HP:0001533)2.27428482
67Cerebral aneurysm (HP:0004944)2.26380999
68Premature skin wrinkling (HP:0100678)2.25092975
69Mitral regurgitation (HP:0001653)2.24601656
70Abnormality of the distal phalanges of the toes (HP:0010182)2.24022627
71Humeroradial synostosis (HP:0003041)2.22372382
72Synostosis involving the elbow (HP:0003938)2.22372382
73Abnormality of skeletal muscle fiber size (HP:0012084)2.22001296
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19852370
75Peritonitis (HP:0002586)2.19492743
76Hypercholesterolemia (HP:0003124)2.17890949
77Insomnia (HP:0100785)2.16554163
78Ulnar deviation of the wrist (HP:0003049)2.15667347
79Back pain (HP:0003418)2.15539040
80Ectopia lentis (HP:0001083)2.14995419
81Blue sclerae (HP:0000592)2.14355044
82Pterygium (HP:0001059)2.13703497
83Advanced eruption of teeth (HP:0006288)2.13576593
84Skin nodule (HP:0200036)2.11669523
85Bell-shaped thorax (HP:0001591)2.11023855
86Hyporeflexia of lower limbs (HP:0002600)2.10786862
87Hemorrhage of the eye (HP:0011885)2.08820528
88Asymmetry of the thorax (HP:0001555)2.08385604
89Mitral valve prolapse (HP:0001634)2.07713207
90Abnormality of dentin (HP:0010299)2.05879196
91Abnormality of carpal bone ossification (HP:0006257)2.05190065
92Abnormal ossification of hand bones (HP:0005921)2.05057138
93Mildly elevated creatine phosphokinase (HP:0008180)2.04731659
94Cervical subluxation (HP:0003308)2.03151612
95Thin bony cortex (HP:0002753)2.03077366
96Abnormality of complement system (HP:0005339)2.02892385
97Rhabdomyolysis (HP:0003201)2.02696876
98Elbow flexion contracture (HP:0002987)2.00244295
99Round ear (HP:0100830)2.00079452
100Long palpebral fissure (HP:0000637)2.00033983
101Hypobetalipoproteinemia (HP:0003563)1.98962558
102Breech presentation (HP:0001623)1.97504366
103Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97012131
104Dicarboxylic aciduria (HP:0003215)1.97012131
105Exercise-induced myalgia (HP:0003738)1.96200958
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.96150540
107Osteolytic defects of the hand bones (HP:0009699)1.96150540
108Hand muscle atrophy (HP:0009130)1.96143171
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.96129985
110Follicular hyperkeratosis (HP:0007502)1.95676965
111Bowing of the arm (HP:0006488)1.95002518
112Bowed forearm bones (HP:0003956)1.95002518
113Osteoarthritis (HP:0002758)1.94104289
114Soft skin (HP:0000977)1.93910222
115Stridor (HP:0010307)1.93203266
116Generalized amyotrophy (HP:0003700)1.92967099
117Abnormality of the calcaneus (HP:0008364)1.91746507
118Spinal cord compression (HP:0002176)1.90095919
119Genu recurvatum (HP:0002816)1.89632571
120Bladder diverticulum (HP:0000015)1.88319248
121Renal duplication (HP:0000075)1.88280593
122Centrally nucleated skeletal muscle fibers (HP:0003687)1.88138922
123Mitral stenosis (HP:0001718)1.87774427
124Abnormality of the Achilles tendon (HP:0005109)1.87563607
125Cupped ribs (HP:0000887)1.87233146
126Tarsal synostosis (HP:0008368)1.85942608
127Aneurysm (HP:0002617)1.85488383
128Bronchomalacia (HP:0002780)1.84852369
129Natal tooth (HP:0000695)1.84031664
130Difficulty climbing stairs (HP:0003551)1.83177254
131Infantile muscular hypotonia (HP:0008947)1.82421840
132Joint laxity (HP:0001388)1.81669707
133Coxa vara (HP:0002812)1.81612744
134Atrophic scars (HP:0001075)1.81247296
135Protuberant abdomen (HP:0001538)1.79518889
136Nuclear cataract (HP:0100018)1.78967281
137Lower limb amyotrophy (HP:0007210)1.78858111
138Aortic aneurysm (HP:0004942)1.78305385
139Patellar dislocation (HP:0002999)1.78272546
140Vitreoretinal degeneration (HP:0000655)1.77288743
141Cardiovascular calcification (HP:0011915)1.77223624
142Abnormality of the acetabulum (HP:0003170)1.76380167
143Wide anterior fontanel (HP:0000260)1.76364784
144Thin ribs (HP:0000883)1.75907492
145Scapular winging (HP:0003691)1.75601362
146Abnormal delivery (HP:0001787)1.75023588
147Dilatation of the ascending aorta (HP:0005111)1.74780634
148Spastic diplegia (HP:0001264)1.74032817
149Buphthalmos (HP:0000557)1.73312367
150Right ventricular cardiomyopathy (HP:0011663)1.72806544
151Cerebral inclusion bodies (HP:0100314)1.72636508
152Fragile skin (HP:0001030)1.72514603
153Hyperextensible skin (HP:0000974)1.72421420
154Dislocated radial head (HP:0003083)1.71463558
155Arnold-Chiari malformation (HP:0002308)1.71438692
156J-shaped sella turcica (HP:0002680)1.71015631
157Lymphangioma (HP:0100764)1.71009406
158Exostoses (HP:0100777)1.69906619
159Overgrowth (HP:0001548)1.69369400
160Flat acetabular roof (HP:0003180)1.68925325
161Muscle fiber inclusion bodies (HP:0100299)1.68840995
162Calcaneovalgus deformity (HP:0001848)1.68548794
163Distal arthrogryposis (HP:0005684)1.68051996
164Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65658702
165Abnormality of the radial head (HP:0003995)1.62823740
166Metatarsus adductus (HP:0001840)1.62783943
167Myopathic facies (HP:0002058)1.62508357
168Venous abnormality (HP:0002624)1.60573621
169Congenital glaucoma (HP:0001087)1.60064887
170Abnormality of the umbilical cord (HP:0010881)1.59363893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.62011817
2SIK14.59077980
3DDR24.22433341
4EPHA23.77922968
5BCKDK3.55232628
6IRAK33.28145280
7CAMK1D2.86047090
8SMG12.70136114
9PKN22.51330390
10ERN12.48548399
11RIPK12.45536395
12PDGFRA2.31551273
13LATS12.31090290
14CAMK1G2.12462701
15NME22.11194914
16TTN2.00886435
17CDK121.98401207
18PRPF4B1.90236685
19LMTK21.81951506
20EPHB11.78119082
21ICK1.67176071
22EPHB21.67147097
23PDK41.54820025
24PDK31.54820025
25TESK11.53030413
26MET1.44891597
27LATS21.43721749
28FGFR21.42230930
29PHKG11.39630138
30PHKG21.39630138
31BMX1.39406706
32FGFR41.33646876
33PRKD31.28920574
34PTK61.26612086
35OBSCN1.26094062
36AKT31.22097678
37PAK21.21717762
38CDK61.21245089
39TAOK21.20893815
40ARAF1.17447708
41MST1R1.12535121
42PRKAA21.04835275
43EEF2K1.02172930
44FGFR10.99088241
45MTOR0.97475496
46PAK30.97072518
47PIK3CA0.95575579
48ILK0.94138163
49MAP2K10.91686433
50LRRK20.91535900
51DYRK1B0.90740170
52MAP3K100.90267737
53PDGFRB0.88267144
54MAP3K30.87552645
55GSK3A0.86163258
56LIMK10.84816717
57STK380.84210445
58TYRO30.83386557
59STK30.79734200
60TGFBR20.77880824
61MARK20.77210510
62PDK20.76770357
63IRAK20.76082406
64CDC42BPA0.74462699
65MAPK110.73723841
66FER0.73519484
67PTK20.73406215
68RPS6KA20.72219249
69STK390.71621558
70ERBB20.71087825
71PIM20.71077206
72INSRR0.70387067
73STK38L0.69754805
74NTRK10.69209957
75CDK70.69099184
76FLT30.69021651
77RET0.68783119
78CDK80.66663505
79SCYL20.66624345
80NEK90.64873795
81PRKD10.64631667
82FGFR30.63803854
83PRKAA10.61992627
84MAP3K70.61615529
85BRAF0.61365450
86ERBB40.59603842
87TESK20.59339627
88PIK3CG0.56877960
89MAP3K80.56210185
90MAP2K30.56105004
91TRPM70.54971174
92MAPKAPK30.54893896
93ROCK10.52555728
94HIPK20.52107806
95EPHA30.51981350
96PAK60.50960093
97TAOK10.50869712
98MAP3K130.50287441
99MAP3K110.49138625
100ABL20.49043868
101PDPK10.47829609
102ROCK20.46984424
103MAPK120.46013541
104PRKCH0.45800437
105WNK40.45644994
106MAP3K10.45056992
107PAK40.43270542
108KSR20.41716474
109MOS0.41600574
110CDK90.40841785
111IGF1R0.40450668
112TIE10.40401797
113INSR0.40106021
114PTK2B0.39315160
115PRKACG0.38892492
116MYLK0.38210067
117MAP3K90.37848657
118RPS6KB20.37583366
119PRKD20.36674929
120RPS6KC10.36179507
121RPS6KL10.36179507
122DMPK0.35436294
123PINK10.35037666
124DAPK30.34773155
125MELK0.34611939
126MAP3K20.34045972
127CSNK1G10.32397020
128CSNK1A1L0.31394349
129MAP3K60.31356856
130MUSK0.30633856
131CDK40.30633802
132SRC0.30542498
133MAP2K20.30470640
134JAK20.30248020
135PRKG20.30116741
136PRKCZ0.29089944
137BRSK10.29027270
138WNK10.28912215
139AKT20.28792529
140MAPKAPK50.28439569
141EPHA40.27062019
142AURKA0.23702495
143CAMK2G0.23031498

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.56995255
2Propanoate metabolism_Homo sapiens_hsa006403.07371430
3PPAR signaling pathway_Homo sapiens_hsa033203.00324940
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.96656063
5Fatty acid metabolism_Homo sapiens_hsa012122.91839463
6Fatty acid degradation_Homo sapiens_hsa000712.91728316
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69520106
8Fatty acid biosynthesis_Homo sapiens_hsa000612.61867353
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.52741909
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38233261
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36484468
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29342271
13Butanoate metabolism_Homo sapiens_hsa006501.95314029
14Prion diseases_Homo sapiens_hsa050201.91054026
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90865383
16Arginine biosynthesis_Homo sapiens_hsa002201.87784220
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87419766
18Pyruvate metabolism_Homo sapiens_hsa006201.80360565
19Other glycan degradation_Homo sapiens_hsa005111.79701277
20Fatty acid elongation_Homo sapiens_hsa000621.79673374
21Chronic myeloid leukemia_Homo sapiens_hsa052201.77597454
22Tryptophan metabolism_Homo sapiens_hsa003801.74860124
23Peroxisome_Homo sapiens_hsa041461.67857275
24Notch signaling pathway_Homo sapiens_hsa043301.67746752
25beta-Alanine metabolism_Homo sapiens_hsa004101.65003396
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62981343
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.61396321
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.59622336
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58714404
30Caffeine metabolism_Homo sapiens_hsa002321.57391006
31Carbon metabolism_Homo sapiens_hsa012001.55156032
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51432941
33Thyroid cancer_Homo sapiens_hsa052161.48594753
34Glycerolipid metabolism_Homo sapiens_hsa005611.48196692
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47563996
36Fat digestion and absorption_Homo sapiens_hsa049751.44628324
37Complement and coagulation cascades_Homo sapiens_hsa046101.44611985
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37521476
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36320467
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33595570
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30974674
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29198849
43Endometrial cancer_Homo sapiens_hsa052131.28171270
44Chemical carcinogenesis_Homo sapiens_hsa052041.27676266
45Non-small cell lung cancer_Homo sapiens_hsa052231.27295813
46Sulfur metabolism_Homo sapiens_hsa009201.25730060
47Pancreatic cancer_Homo sapiens_hsa052121.24766614
48Starch and sucrose metabolism_Homo sapiens_hsa005001.23699840
49Steroid biosynthesis_Homo sapiens_hsa001001.23519645
50VEGF signaling pathway_Homo sapiens_hsa043701.20694781
51ECM-receptor interaction_Homo sapiens_hsa045121.20318568
52Biosynthesis of amino acids_Homo sapiens_hsa012301.16975854
53Bile secretion_Homo sapiens_hsa049761.16638286
54Glioma_Homo sapiens_hsa052141.16221394
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15747739
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13660407
57Acute myeloid leukemia_Homo sapiens_hsa052211.12931748
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.10997687
59Phenylalanine metabolism_Homo sapiens_hsa003601.09677875
60Renal cell carcinoma_Homo sapiens_hsa052111.08576002
61Vitamin B6 metabolism_Homo sapiens_hsa007501.08565609
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07748255
63mTOR signaling pathway_Homo sapiens_hsa041501.07254397
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06355629
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.05943696
66Vibrio cholerae infection_Homo sapiens_hsa051101.02966689
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.02713149
68Histidine metabolism_Homo sapiens_hsa003401.01614374
69ErbB signaling pathway_Homo sapiens_hsa040120.99406741
70MicroRNAs in cancer_Homo sapiens_hsa052060.99325989
71Prostate cancer_Homo sapiens_hsa052150.99295424
72Retinol metabolism_Homo sapiens_hsa008300.98876262
73AMPK signaling pathway_Homo sapiens_hsa041520.98334733
74Tyrosine metabolism_Homo sapiens_hsa003500.98259722
75Lysine degradation_Homo sapiens_hsa003100.97418204
76Protein digestion and absorption_Homo sapiens_hsa049740.92735028
77Thyroid hormone synthesis_Homo sapiens_hsa049180.91034461
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.89542547
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88511160
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85790673
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83347852
82Estrogen signaling pathway_Homo sapiens_hsa049150.83102755
83Arginine and proline metabolism_Homo sapiens_hsa003300.80976651
84Insulin resistance_Homo sapiens_hsa049310.80911401
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.80340152
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79462272
87Sulfur relay system_Homo sapiens_hsa041220.76220956
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73805081
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73170072
90Melanoma_Homo sapiens_hsa052180.71245884
91Staphylococcus aureus infection_Homo sapiens_hsa051500.70476068
92N-Glycan biosynthesis_Homo sapiens_hsa005100.69605616
93Focal adhesion_Homo sapiens_hsa045100.69149460
94Pentose phosphate pathway_Homo sapiens_hsa000300.67851459
95Melanogenesis_Homo sapiens_hsa049160.67014833
96Selenocompound metabolism_Homo sapiens_hsa004500.66759280
97GnRH signaling pathway_Homo sapiens_hsa049120.64789622
98Basal cell carcinoma_Homo sapiens_hsa052170.64442379
99Axon guidance_Homo sapiens_hsa043600.64001774
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.62797253
101Colorectal cancer_Homo sapiens_hsa052100.62590307
102Choline metabolism in cancer_Homo sapiens_hsa052310.61147531
103Pathways in cancer_Homo sapiens_hsa052000.60542177
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.59673980
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59511399
106Folate biosynthesis_Homo sapiens_hsa007900.57308197
107ABC transporters_Homo sapiens_hsa020100.56618393
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.55756098
109Insulin signaling pathway_Homo sapiens_hsa049100.55416701
110Wnt signaling pathway_Homo sapiens_hsa043100.54703881
111Endocytosis_Homo sapiens_hsa041440.52535569
112Bladder cancer_Homo sapiens_hsa052190.51443822
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.51226907
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51218342
115Glutathione metabolism_Homo sapiens_hsa004800.50644313
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48557531
117Lysosome_Homo sapiens_hsa041420.48007690
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47506304
119Proteoglycans in cancer_Homo sapiens_hsa052050.44772302
120Glucagon signaling pathway_Homo sapiens_hsa049220.43450960
121Vitamin digestion and absorption_Homo sapiens_hsa049770.42893251
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42717330
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38320941
124Amoebiasis_Homo sapiens_hsa051460.36543561
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35105967
126Hippo signaling pathway_Homo sapiens_hsa043900.32858737
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32523274
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.32190226
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32178438
130Fructose and mannose metabolism_Homo sapiens_hsa000510.30559753
131Hedgehog signaling pathway_Homo sapiens_hsa043400.27455833
132Metabolic pathways_Homo sapiens_hsa011000.27419621
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26872245
134Galactose metabolism_Homo sapiens_hsa000520.26645662
135Small cell lung cancer_Homo sapiens_hsa052220.26592898
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24856976
137Dilated cardiomyopathy_Homo sapiens_hsa054140.24752294
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23109159
139Tight junction_Homo sapiens_hsa045300.22863838
140Adherens junction_Homo sapiens_hsa045200.22608813
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22132601
142TGF-beta signaling pathway_Homo sapiens_hsa043500.21892857
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20286188
144Linoleic acid metabolism_Homo sapiens_hsa005910.20267055
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19230910

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