FGFR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.28380826
2central nervous system myelination (GO:0022010)8.28380826
3fatty acid elongation (GO:0030497)5.90667973
4presynaptic membrane assembly (GO:0097105)5.03051949
5myelination (GO:0042552)4.96160543
6axon ensheathment (GO:0008366)4.95621385
7ensheathment of neurons (GO:0007272)4.95621385
8myelin maintenance (GO:0043217)4.11221660
9notochord development (GO:0030903)4.04176893
10myelination in peripheral nervous system (GO:0022011)3.89112383
11peripheral nervous system axon ensheathment (GO:0032292)3.89112383
12* lateral sprouting from an epithelium (GO:0060601)3.82265003
13apical protein localization (GO:0045176)3.79070078
14paraxial mesoderm development (GO:0048339)3.73488975
15adhesion of symbiont to host cell (GO:0044650)3.73370523
16virion attachment to host cell (GO:0019062)3.73370523
17asymmetric protein localization (GO:0008105)3.72823293
18oligodendrocyte differentiation (GO:0048709)3.70438660
19regulation of posttranscriptional gene silencing (GO:0060147)3.66353254
20regulation of gene silencing by miRNA (GO:0060964)3.66353254
21regulation of gene silencing by RNA (GO:0060966)3.66353254
22photoreceptor cell differentiation (GO:0046530)3.55024113
23eye photoreceptor cell differentiation (GO:0001754)3.55024113
24vocalization behavior (GO:0071625)3.54721567
25long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.48171653
26long-chain fatty acid biosynthetic process (GO:0042759)3.46524846
27postsynaptic membrane organization (GO:0001941)3.29760256
28surfactant homeostasis (GO:0043129)3.26937779
29convergent extension (GO:0060026)3.26152664
30* regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.22963364
31bone trabecula formation (GO:0060346)3.22339140
32negative regulation of neurotransmitter secretion (GO:0046929)3.20706781
33negative regulation of protein localization to cell surface (GO:2000009)3.18591374
34* digestive tract morphogenesis (GO:0048546)3.18457647
35very long-chain fatty acid metabolic process (GO:0000038)3.16935104
36fatty-acyl-CoA biosynthetic process (GO:0046949)3.11389254
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.08677029
38cholesterol biosynthetic process (GO:0006695)3.06293662
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.05950843
40L-phenylalanine catabolic process (GO:0006559)3.05950843
41neuron cell-cell adhesion (GO:0007158)3.04607975
42adhesion of symbiont to host (GO:0044406)3.01706785
43regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.00757926
44cellular response to cholesterol (GO:0071397)3.00401928
45astrocyte development (GO:0014002)3.00084690
46negative regulation of translation, ncRNA-mediated (GO:0040033)2.97768732
47regulation of translation, ncRNA-mediated (GO:0045974)2.97768732
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97768732
49long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.97570846
50cochlea development (GO:0090102)2.95824989
51embryonic retina morphogenesis in camera-type eye (GO:0060059)2.93969391
52regulation of collateral sprouting (GO:0048670)2.92474226
53hemidesmosome assembly (GO:0031581)2.90535562
54glycerophospholipid catabolic process (GO:0046475)2.82688250
55cell surface receptor signaling pathway involved in heart development (GO:0061311)2.78083823
56lung epithelium development (GO:0060428)2.77042483
57regulation of cell fate specification (GO:0042659)2.77008270
58negative regulation of neurotransmitter transport (GO:0051589)2.76557425
59mesenchymal-epithelial cell signaling (GO:0060638)2.76231082
60amino acid import (GO:0043090)2.71761355
61L-amino acid import (GO:0043092)2.71374905
62hyperosmotic salinity response (GO:0042538)2.70313923
63* midbrain development (GO:0030901)2.69525427
64import into cell (GO:0098657)2.68986512
65negative regulation of JUN kinase activity (GO:0043508)2.68068752
66midgut development (GO:0007494)2.67759669
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67169288
68fatty-acyl-CoA metabolic process (GO:0035337)2.64782985
69peptidyl-tyrosine autophosphorylation (GO:0038083)2.63962864
70sodium ion export (GO:0071436)2.63323696
71synaptic vesicle docking involved in exocytosis (GO:0016081)2.62686201
72regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.62554541
73protein localization to endosome (GO:0036010)2.62439515
74camera-type eye morphogenesis (GO:0048593)2.61874454
75cerebral cortex radially oriented cell migration (GO:0021799)2.61746504
76Leydig cell differentiation (GO:0033327)2.61721559
77sterol biosynthetic process (GO:0016126)2.61516780
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59670777
79* limb bud formation (GO:0060174)2.58422236
80L-phenylalanine metabolic process (GO:0006558)2.58177048
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58177048
82interleukin-6-mediated signaling pathway (GO:0070102)2.57961790
83cellular potassium ion homeostasis (GO:0030007)2.57715848
84negative regulation of axon guidance (GO:1902668)2.56814834
85positive regulation of catenin import into nucleus (GO:0035413)2.56474656
86chemical homeostasis within a tissue (GO:0048875)2.55576548
87negative regulation of astrocyte differentiation (GO:0048712)2.55173996
88membrane tubulation (GO:0097320)2.55170731
89amyloid precursor protein metabolic process (GO:0042982)2.53460127
90dorsal/ventral axis specification (GO:0009950)2.53445501
91negative regulation of catenin import into nucleus (GO:0035414)2.52529566
92regulation of catenin import into nucleus (GO:0035412)2.52040623
93developmental induction (GO:0031128)2.50955236
94renal filtration (GO:0097205)2.50541029
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.50393869
96cell communication by electrical coupling (GO:0010644)2.50032150
97glomerular filtration (GO:0003094)2.49847544
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49295861
99cell proliferation involved in kidney development (GO:0072111)2.48945403
100response to lipoprotein particle (GO:0055094)2.48489541
101establishment of planar polarity (GO:0001736)2.47523570
102establishment of tissue polarity (GO:0007164)2.47523570
103negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46160479
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45780542
105response to methylmercury (GO:0051597)2.44080656
106regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.43895671
107regulation of axon extension involved in axon guidance (GO:0048841)2.43546081
108cell-cell signaling involved in cell fate commitment (GO:0045168)2.43067687
109negative regulation of glial cell differentiation (GO:0045686)2.42903714
110establishment of nucleus localization (GO:0040023)2.42813991
111cellular response to sterol (GO:0036315)2.42659627
112creatine metabolic process (GO:0006600)2.42571111
113regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42543795
114regulation of cardioblast differentiation (GO:0051890)2.42302801
115neuronal stem cell maintenance (GO:0097150)2.42281233
116gap junction assembly (GO:0016264)2.41821159
117cellular sodium ion homeostasis (GO:0006883)2.41785104
118thioester biosynthetic process (GO:0035384)2.40658101
119acyl-CoA biosynthetic process (GO:0071616)2.40658101
120* lung-associated mesenchyme development (GO:0060484)2.40348114
121* otic vesicle formation (GO:0030916)2.39477372
122negative regulation of axon extension (GO:0030517)2.39392193
123transmission of nerve impulse (GO:0019226)2.38878668
124* organ growth (GO:0035265)2.38701715
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38408981
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37889736
127regulation of somitogenesis (GO:0014807)2.35637983
128extracellular matrix assembly (GO:0085029)2.34381044
129cerebellar granule cell differentiation (GO:0021707)2.34145757
130pattern specification involved in kidney development (GO:0061004)2.33488863
131renal system development (GO:0072001)2.33212178
132negative regulation of axonogenesis (GO:0050771)2.32639862
133radial glial cell differentiation (GO:0060019)2.32523335
134cranial nerve development (GO:0021545)2.31966782
135serine family amino acid catabolic process (GO:0009071)2.31798639
136regulation of establishment of planar polarity (GO:0090175)2.31721057
137kidney morphogenesis (GO:0060993)2.31687778
138negative regulation of cell fate commitment (GO:0010454)2.30886757
139anterior/posterior axis specification, embryo (GO:0008595)2.30475470
140mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29722735
141establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.29628103
142post-anal tail morphogenesis (GO:0036342)2.29105476
143regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28087562
144genitalia morphogenesis (GO:0035112)2.28032149
145cell proliferation involved in metanephros development (GO:0072203)2.27159128
146negative regulation of keratinocyte proliferation (GO:0010839)2.26369333
147response to lead ion (GO:0010288)2.25697291
148somite development (GO:0061053)2.25522653
149glial cell differentiation (GO:0010001)2.25063166
150neurotransmitter uptake (GO:0001504)2.24219430
151neuroblast proliferation (GO:0007405)2.23821438
152exploration behavior (GO:0035640)2.23775760
153atrial cardiac muscle cell action potential (GO:0086014)2.21316267
154ephrin receptor signaling pathway (GO:0048013)2.21228089
155neuronal ion channel clustering (GO:0045161)2.21190362
156negative regulation of hormone biosynthetic process (GO:0032353)2.21005896
157* craniofacial suture morphogenesis (GO:0097094)2.20684474
158non-canonical Wnt signaling pathway (GO:0035567)2.20291028
159glutamate receptor signaling pathway (GO:0007215)2.20281152
160negative regulation of cell fate specification (GO:0009996)2.20066715
161enteric nervous system development (GO:0048484)2.19741397
162membrane assembly (GO:0071709)2.18521213
163locomotory exploration behavior (GO:0035641)2.18496977
164somatic stem cell maintenance (GO:0035019)2.18373914
165ionotropic glutamate receptor signaling pathway (GO:0035235)2.17809601
166regulation of axon guidance (GO:1902667)2.17650654
167outer ear morphogenesis (GO:0042473)2.16964640
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16766044
169presynaptic membrane organization (GO:0097090)2.15387552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.98753098
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.60426013
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57895430
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34756349
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.33015108
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22536152
7* EED_16625203_ChIP-ChIP_MESCs_Mouse2.17772315
8AR_21572438_ChIP-Seq_LNCaP_Human2.11006203
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05249501
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05249501
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00826959
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00170739
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99862242
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97709891
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96139624
16GBX2_23144817_ChIP-Seq_PC3_Human1.95346397
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95188249
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90696988
19FUS_26573619_Chip-Seq_HEK293_Human1.89320455
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88350987
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.87651387
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86150997
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85284452
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.84068283
25* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82524546
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81963512
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79962106
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75584594
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75004120
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.73883318
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73282845
32* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71720580
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71236543
34* RNF2_27304074_Chip-Seq_ESCs_Mouse1.63662133
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61768348
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61063057
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60939377
38* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58300221
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57998297
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57775819
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55995079
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50533905
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50533905
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48984434
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48984434
46REST_21632747_ChIP-Seq_MESCs_Mouse1.48131373
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46200762
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.44778849
49* EZH2_27294783_Chip-Seq_ESCs_Mouse1.44746166
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.43926668
51* AHR_22903824_ChIP-Seq_MCF-7_Human1.43098622
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42522060
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41701586
54RNF2_27304074_Chip-Seq_NSC_Mouse1.40607532
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.40519820
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35791614
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35791614
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35791614
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35463425
60* ARNT_22903824_ChIP-Seq_MCF-7_Human1.35436642
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35041464
62* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34511080
63* LXR_22158963_ChIP-Seq_LIVER_Mouse1.33566800
64EWS_26573619_Chip-Seq_HEK293_Human1.33545642
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.33198787
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.33027334
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32941351
68DROSHA_22980978_ChIP-Seq_HELA_Human1.32832901
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31932250
70* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31690245
71* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31311157
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30049326
73* SOX2_16153702_ChIP-ChIP_HESCs_Human1.29534130
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.29179957
75* TP53_18474530_ChIP-ChIP_U2OS_Human1.29148105
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28265316
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27190421
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24915129
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.24815203
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24525957
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22548184
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20985202
83* SMAD3_21741376_ChIP-Seq_HESCs_Human1.20973337
84* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20755830
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20204327
86* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18735021
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17945836
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17080973
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.16696628
90* SMAD3_21741376_ChIP-Seq_ESCs_Human1.16530093
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16106885
92* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15222335
93* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15023413
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14627592
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.14561378
96* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14519209
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14067867
98* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12818106
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10436849
100TP53_16413492_ChIP-PET_HCT116_Human1.10093160
101* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10022844
102CJUN_26792858_Chip-Seq_BT549_Human1.09946059
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09078630
104SOX9_26525672_Chip-Seq_HEART_Mouse1.08752970
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08520197
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07776754
107STAT3_23295773_ChIP-Seq_U87_Human1.06926148
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06559409
109* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06536530
110RXR_22158963_ChIP-Seq_LIVER_Mouse1.06526717
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05481375
112* NANOG_16153702_ChIP-ChIP_HESCs_Human1.05382538
113* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04561035
114TAF15_26573619_Chip-Seq_HEK293_Human1.04514303
115* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04040483
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03608828
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03370582
118* AR_19668381_ChIP-Seq_PC3_Human1.03134369
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02800663
120TCF4_23295773_ChIP-Seq_U87_Human1.02508675
121* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01884253
122* SOX2_20726797_ChIP-Seq_SW620_Human1.01427328
123* RING1B_27294783_Chip-Seq_ESCs_Mouse1.01317753
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00111731
125* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98491919
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97874259
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97259695
128* P300_19829295_ChIP-Seq_ESCs_Human0.96397379
129ER_23166858_ChIP-Seq_MCF-7_Human0.96352647
130* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95790360
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.95291166
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94448707
133* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93921865
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93910336
135* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93630540
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.92887355
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92395051
138* RXR_22108803_ChIP-Seq_LS180_Human0.90058365
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88882362
140* TP63_23658742_ChIP-Seq_EP156T_Human0.88691150
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.88430981
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88246106
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.86634705
144* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86479562
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85758161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.50830376
2MP0003690_abnormal_glial_cell2.55394889
3MP0004272_abnormal_basement_membrane2.52513836
4* MP0010678_abnormal_skin_adnexa2.49727567
5MP0004885_abnormal_endolymph2.48576364
6MP0008438_abnormal_cutaneous_collagen2.47308864
7MP0003950_abnormal_plasma_membrane2.46926600
8* MP0010030_abnormal_orbit_morphology2.38718228
9* MP0000383_abnormal_hair_follicle2.37095003
10MP0001958_emphysema2.28972165
11MP0005377_hearing/vestibular/ear_phenot2.26578465
12MP0003878_abnormal_ear_physiology2.26578465
13MP0003136_yellow_coat_color2.13826399
14MP0005503_abnormal_tendon_morphology2.13486233
15MP0004859_abnormal_synaptic_plasticity2.07717216
16MP0005275_abnormal_skin_tensile2.01918133
17* MP0000647_abnormal_sebaceous_gland1.99761987
18* MP0000762_abnormal_tongue_morphology1.98473548
19MP0004381_abnormal_hair_follicle1.97649082
20MP0003329_amyloid_beta_deposits1.97048929
21MP0003890_abnormal_embryonic-extraembry1.95854597
22MP0002938_white_spotting1.93565924
23MP0009384_cardiac_valve_regurgitation1.91292077
24MP0001984_abnormal_olfaction1.88263788
25MP0004782_abnormal_surfactant_physiolog1.84867001
26* MP0001177_atelectasis1.78609518
27MP0006292_abnormal_olfactory_placode1.74308096
28MP0009053_abnormal_anal_canal1.73230436
29MP0002697_abnormal_eye_size1.73063549
30* MP0003937_abnormal_limbs/digits/tail_de1.73033122
31MP0005171_absent_coat_pigmentation1.70746998
32* MP0000462_abnormal_digestive_system1.68271230
33MP0002254_reproductive_system_inflammat1.67714129
34MP0009379_abnormal_foot_pigmentation1.66725954
35* MP0002098_abnormal_vibrissa_morphology1.64967476
36* MP0009250_abnormal_appendicular_skeleto1.64516987
37MP0002796_impaired_skin_barrier1.62324587
38MP0003119_abnormal_digestive_system1.62286144
39MP0004133_heterotaxia1.61709703
40MP0005083_abnormal_biliary_tract1.61069268
41MP0002064_seizures1.59583686
42MP0005423_abnormal_somatic_nervous1.57483829
43MP0000467_abnormal_esophagus_morphology1.54823847
44* MP0000579_abnormal_nail_morphology1.54269417
45MP0003635_abnormal_synaptic_transmissio1.54048085
46MP0005248_abnormal_Harderian_gland1.49818496
47* MP0000566_synostosis1.49134061
48MP0000534_abnormal_ureter_morphology1.49035559
49MP0003942_abnormal_urinary_system1.48875229
50MP0002139_abnormal_hepatobiliary_system1.48833360
51* MP0001299_abnormal_eye_distance/1.47382987
52MP0003385_abnormal_body_wall1.46627889
53MP0003122_maternal_imprinting1.46615395
54MP0004134_abnormal_chest_morphology1.44786241
55* MP0002295_abnormal_pulmonary_circulatio1.44483201
56MP0003632_abnormal_nervous_system1.41996977
57* MP0003634_abnormal_glial_cell1.41381686
58MP0005187_abnormal_penis_morphology1.40684713
59* MP0000778_abnormal_nervous_system1.38824719
60MP0005409_darkened_coat_color1.35668482
61MP0009840_abnormal_foam_cell1.34553070
62MP0009745_abnormal_behavioral_response1.33755126
63MP0002734_abnormal_mechanical_nocicepti1.33238646
64MP0002272_abnormal_nervous_system1.32127053
65MP0001293_anophthalmia1.29888947
66MP0002063_abnormal_learning/memory/cond1.29504901
67MP0003283_abnormal_digestive_organ1.27950655
68* MP0003755_abnormal_palate_morphology1.26003411
69* MP0001340_abnormal_eyelid_morphology1.25195708
70* MP0002133_abnormal_respiratory_system1.24757222
71* MP0005388_respiratory_system_phenotype1.24757222
72MP0005408_hypopigmentation1.23573332
73* MP0003861_abnormal_nervous_system1.23455654
74* MP0000631_abnormal_neuroendocrine_gland1.21911186
75MP0001661_extended_life_span1.19936333
76* MP0000428_abnormal_craniofacial_morphol1.18455442
77MP0001286_abnormal_eye_development1.17870327
78MP0004270_analgesia1.17785001
79MP0005646_abnormal_pituitary_gland1.17573241
80MP0005623_abnormal_meninges_morphology1.16863786
81MP0002572_abnormal_emotion/affect_behav1.15564480
82MP0001485_abnormal_pinna_reflex1.15471952
83MP0004742_abnormal_vestibular_system1.14498721
84MP0002249_abnormal_larynx_morphology1.14435349
85* MP0000377_abnormal_hair_follicle1.12612791
86* MP0005508_abnormal_skeleton_morphology1.11938597
87MP0005085_abnormal_gallbladder_physiolo1.10931327
88MP0010368_abnormal_lymphatic_system1.08155744
89* MP0009672_abnormal_birth_weight1.07823276
90MP0008569_lethality_at_weaning1.07152366
91MP0003880_abnormal_central_pattern1.07125079
92* MP0000026_abnormal_inner_ear1.07116264
93MP0001486_abnormal_startle_reflex1.03546256
94MP0002653_abnormal_ependyma_morphology1.03125500
95MP0002060_abnormal_skin_morphology1.02959667
96* MP0002152_abnormal_brain_morphology1.02784344
97MP0002557_abnormal_social/conspecific_i1.02652604
98MP0008875_abnormal_xenobiotic_pharmacok1.02486479
99MP0001963_abnormal_hearing_physiology1.00796919
100MP0002089_abnormal_postnatal_growth/wei0.99561265
101MP0001501_abnormal_sleep_pattern0.99559994
102MP0005499_abnormal_olfactory_system0.99006323
103MP0005394_taste/olfaction_phenotype0.99006323
104MP0009780_abnormal_chondrocyte_physiolo0.98150100
105MP0001968_abnormal_touch/_nociception0.97890435
106MP0000604_amyloidosis0.97650059
107MP0002092_abnormal_eye_morphology0.97125962
108MP0003806_abnormal_nucleotide_metabolis0.96708653
109* MP0002111_abnormal_tail_morphology0.95973049
110MP0010234_abnormal_vibrissa_follicle0.95787765
111MP0004264_abnormal_extraembryonic_tissu0.94841361
112MP0005551_abnormal_eye_electrophysiolog0.94702822
113MP0009046_muscle_twitch0.94381997
114* MP0009703_decreased_birth_body0.94045792
115* MP0002882_abnormal_neuron_morphology0.93831687
116* MP0002084_abnormal_developmental_patter0.93302690
117* MP0002233_abnormal_nose_morphology0.93173664
118* MP0003935_abnormal_craniofacial_develop0.92701201
119MP0001849_ear_inflammation0.91782303
120MP0004185_abnormal_adipocyte_glucose0.89118819
121* MP0000432_abnormal_head_morphology0.88818537
122* MP0002116_abnormal_craniofacial_bone0.88656161
123MP0001502_abnormal_circadian_rhythm0.87121463
124MP0002896_abnormal_bone_mineralization0.86916982
125MP0003567_abnormal_fetal_cardiomyocyte0.86377397
126* MP0003938_abnormal_ear_development0.85775344
127MP0000049_abnormal_middle_ear0.84644738
128MP0002752_abnormal_somatic_nervous0.84186859
129MP0002736_abnormal_nociception_after0.84139387
130MP0000955_abnormal_spinal_cord0.83704611
131MP0001851_eye_inflammation0.83481534
132MP0002184_abnormal_innervation0.82994468
133* MP0003115_abnormal_respiratory_system0.81358505
134* MP0002108_abnormal_muscle_morphology0.81224852
135MP0001529_abnormal_vocalization0.81164800
136MP0008789_abnormal_olfactory_epithelium0.81069205
137MP0005391_vision/eye_phenotype0.80535883
138MP0000733_abnormal_muscle_development0.80412445
139MP0006276_abnormal_autonomic_nervous0.80111435
140MP0003941_abnormal_skin_development0.79978956
141MP0004043_abnormal_pH_regulation0.79827094
142* MP0002085_abnormal_embryonic_tissue0.79633919
143MP0000613_abnormal_salivary_gland0.79068073
144* MP0000537_abnormal_urethra_morphology0.78970393
145MP0001440_abnormal_grooming_behavior0.78585791
146* MP0002932_abnormal_joint_morphology0.77980669
147MP0002177_abnormal_outer_ear0.77712144
148MP0003705_abnormal_hypodermis_morpholog0.77445919
149MP0002234_abnormal_pharynx_morphology0.77341554
150MP0001188_hyperpigmentation0.77160364
151* MP0010771_integument_phenotype0.75339510
152* MP0003453_abnormal_keratinocyte_physiol0.75123551
153* MP0002282_abnormal_trachea_morphology0.74987160
154MP0002067_abnormal_sensory_capabilities0.74810346
155* MP0002109_abnormal_limb_morphology0.74324511
156* MP0000163_abnormal_cartilage_morphology0.74181305
157* MP0001346_abnormal_lacrimal_gland0.73847472

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.52472690
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.23403849
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23403849
4Cerebral inclusion bodies (HP:0100314)4.00959373
5Midline defect of the nose (HP:0004122)3.58597101
6Septo-optic dysplasia (HP:0100842)3.46311929
7Parakeratosis (HP:0001036)3.41755147
8Sensory axonal neuropathy (HP:0003390)3.33099330
9* Partial duplication of thumb phalanx (HP:0009944)3.21672017
10Infantile muscular hypotonia (HP:0008947)3.21341184
11Milia (HP:0001056)3.11095394
12* Cutaneous finger syndactyly (HP:0010554)3.04761828
13Abnormality of the corticospinal tract (HP:0002492)2.99409427
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93902705
15Short 4th metacarpal (HP:0010044)2.93902705
16Focal motor seizures (HP:0011153)2.93841649
17* Cutaneous syndactyly (HP:0012725)2.93439144
18Myokymia (HP:0002411)2.92706016
19Premature rupture of membranes (HP:0001788)2.91256355
20Hepatoblastoma (HP:0002884)2.83734274
21* Alacrima (HP:0000522)2.79835510
22Fragile nails (HP:0001808)2.77562546
23Atrophic scars (HP:0001075)2.71644740
24* Coronal craniosynostosis (HP:0004440)2.71200897
25* Partial duplication of the phalanx of hand (HP:0009999)2.68929774
26* Aplasia of the phalanges of the hand (HP:0009802)2.64948450
27* Aplasia involving bones of the extremities (HP:0009825)2.64948450
28* Aplasia involving bones of the upper limbs (HP:0009823)2.64948450
29Neonatal short-limb short stature (HP:0008921)2.61481101
30* Abnormality of the parietal bone (HP:0002696)2.58729998
31Deep venous thrombosis (HP:0002625)2.57946110
32* Preaxial foot polydactyly (HP:0001841)2.57934185
33Supranuclear gaze palsy (HP:0000605)2.54895914
34Intention tremor (HP:0002080)2.53332048
35Onycholysis (HP:0001806)2.52770642
36Vitreoretinal degeneration (HP:0000655)2.52752016
37Bilateral microphthalmos (HP:0007633)2.48033450
38Onion bulb formation (HP:0003383)2.45577459
39Concave nail (HP:0001598)2.44495516
40Abnormality of the 4th metacarpal (HP:0010012)2.41979998
41White forelock (HP:0002211)2.41852121
42Renal hypoplasia (HP:0000089)2.40968035
43Aplasia/Hypoplasia of the sternum (HP:0006714)2.38756079
44* Abnormality of the dental root (HP:0006486)2.37929200
45* Taurodontia (HP:0000679)2.37929200
46* Abnormality of permanent molar morphology (HP:0011071)2.37929200
47Large earlobe (HP:0009748)2.35121324
48Abnormality of cochlea (HP:0000375)2.32228685
49Hypoplasia of the iris (HP:0007676)2.30397025
50Aplasia cutis congenita (HP:0001057)2.26945985
51Maternal diabetes (HP:0009800)2.26930212
52Peripheral hypomyelination (HP:0007182)2.26734549
53Focal seizures (HP:0007359)2.19025183
54Tubulointerstitial fibrosis (HP:0005576)2.18251746
55Hyperlipoproteinemia (HP:0010980)2.18110421
56Stridor (HP:0010307)2.17915619
57Patchy hypopigmentation of hair (HP:0011365)2.16852290
58Bifid tongue (HP:0010297)2.16527914
59Microglossia (HP:0000171)2.16431703
60Follicular hyperkeratosis (HP:0007502)2.15631986
61* Abnormality of the dental pulp (HP:0006479)2.15504981
62Absent eyelashes (HP:0000561)2.14769269
63* Split foot (HP:0001839)2.13406442
64Colon cancer (HP:0003003)2.13211958
65* Abnormality of molar morphology (HP:0011070)2.13119860
66* Abnormality of molar (HP:0011077)2.13119860
67* Bifid scrotum (HP:0000048)2.12862876
68Optic nerve hypoplasia (HP:0000609)2.12633513
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12502366
70* Humeroradial synostosis (HP:0003041)2.12322993
71* Synostosis involving the elbow (HP:0003938)2.12322993
72Intrahepatic cholestasis (HP:0001406)2.12162351
73* Bronchomalacia (HP:0002780)2.11989869
74Abnormality of the fetal cardiovascular system (HP:0010948)2.11011638
75Abnormal umbilical cord blood vessels (HP:0011403)2.11011638
76Single umbilical artery (HP:0001195)2.11011638
77Termporal pattern (HP:0011008)2.09228583
78Insidious onset (HP:0003587)2.09228583
79Absent eyebrow (HP:0002223)2.08232427
80* Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.07189132
81* Choanal stenosis (HP:0000452)2.07005902
82* Anteriorly placed anus (HP:0001545)2.06287865
83* Nasolacrimal duct obstruction (HP:0000579)2.05885025
84Adrenal hypoplasia (HP:0000835)2.03267071
85Congenital ichthyosiform erythroderma (HP:0007431)2.00216282
86Abnormality of the nasal septum (HP:0000419)2.00155142
87Abnormality of the diencephalon (HP:0010662)1.99813839
88* Abnormality of the nasolacrimal system (HP:0000614)1.96686869
89* Shallow orbits (HP:0000586)1.96434333
90Glomerulosclerosis (HP:0000096)1.96375190
91Intestinal atresia (HP:0011100)1.92474855
92Interstitial pulmonary disease (HP:0006530)1.91790464
93Abnormal auditory evoked potentials (HP:0006958)1.91674664
94* Duplication of thumb phalanx (HP:0009942)1.91489412
95* Mixed hearing impairment (HP:0000410)1.90627553
96* Abnormality of the middle phalanges of the toes (HP:0010183)1.90586370
97* Abnormality of the lacrimal duct (HP:0011481)1.89648421
98* Decreased lacrimation (HP:0000633)1.87963060
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87913654
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87154921
101Anophthalmia (HP:0000528)1.84318905
102* Broad metatarsal (HP:0001783)1.84267672
103Neoplasm of the oral cavity (HP:0100649)1.84035979
104Cardiovascular calcification (HP:0011915)1.83554531
105Myelomeningocele (HP:0002475)1.82427383
106Absent hair (HP:0002298)1.82411103
107Focal segmental glomerulosclerosis (HP:0000097)1.81779697
108* Abnormality of the salivary glands (HP:0010286)1.81329816
109* Esophageal atresia (HP:0002032)1.81169021
110Hypophosphatemic rickets (HP:0004912)1.80823229
111Xanthomatosis (HP:0000991)1.80448767
112Hyporeflexia of lower limbs (HP:0002600)1.79801672
113Bicornuate uterus (HP:0000813)1.79555129
114Renal salt wasting (HP:0000127)1.79138849
115Omphalocele (HP:0001539)1.78636702
116Scanning speech (HP:0002168)1.78377993
117Progressive cerebellar ataxia (HP:0002073)1.78062842
118Clumsiness (HP:0002312)1.78014915
119Hypotrichosis (HP:0001006)1.76594760
120Spastic gait (HP:0002064)1.75903734
121* Cupped ear (HP:0000378)1.74948389
122Abnormality of the aortic arch (HP:0012303)1.74409452
123Abnormal lung lobation (HP:0002101)1.74396980
124Hemivertebrae (HP:0002937)1.74201878
125Morphological abnormality of the inner ear (HP:0011390)1.73587084
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.72817356
127Osteolytic defects of the hand bones (HP:0009699)1.72817356
128Aortic dissection (HP:0002647)1.72246683
129Down-sloping shoulders (HP:0200021)1.72123122
130* Respiratory distress (HP:0002098)1.71661953
131Limited hip movement (HP:0008800)1.71338919
132Vascular calcification (HP:0004934)1.70928436
133* Gastrointestinal atresia (HP:0002589)1.70446581
134Pterygium (HP:0001059)1.69201550
135Dysmetria (HP:0001310)1.68483142
136Spastic paraparesis (HP:0002313)1.68099016
137Arterial tortuosity (HP:0005116)1.66778884
138Abnormality of the ischium (HP:0003174)1.66177072
139Ileus (HP:0002595)1.66112973
140Short phalanx of the thumb (HP:0009660)1.65158569
141Chronic bronchitis (HP:0004469)1.63698521
142Scapular winging (HP:0003691)1.63583572
143* Vaginal atresia (HP:0000148)1.61231535
144Neoplasm of the heart (HP:0100544)1.60866187
145Action tremor (HP:0002345)1.60714535
146Increased nuchal translucency (HP:0010880)1.60210195
147Increased circulating renin level (HP:0000848)1.60123593
148Abnormal hand bone ossification (HP:0010660)1.60026570
149Peritonitis (HP:0002586)1.59702315
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59656444
151Hyperglycinuria (HP:0003108)1.59395150
152Cerebral hypomyelination (HP:0006808)1.58954864
153Hypoplastic pelvis (HP:0008839)1.58705179
154* Absent septum pellucidum (HP:0001331)1.57751585
155* Genital tract atresia (HP:0001827)1.57408723
156Atonic seizures (HP:0010819)1.57297504
157Hamartoma (HP:0010566)1.54694573
158Shawl scrotum (HP:0000049)1.54605484
159Morphological abnormality of the middle ear (HP:0008609)1.54160113
160Right ventricular cardiomyopathy (HP:0011663)1.53370808
161High anterior hairline (HP:0009890)1.52675161
162* 2-3 toe syndactyly (HP:0004691)1.51857227
163* Abnormality of the labia minora (HP:0012880)1.51428774
164* Labial hypoplasia (HP:0000066)1.50389757
165Supernumerary ribs (HP:0005815)1.49753008
166* Abnormality of the septum pellucidum (HP:0007375)1.49627748
167Renal dysplasia (HP:0000110)1.49007251
168* Megalencephaly (HP:0001355)1.48688094
169Broad-based gait (HP:0002136)1.46914305
170* Preaxial hand polydactyly (HP:0001177)1.45329795
171* Abnormality of the antihelix (HP:0009738)1.44949693
172Epileptic encephalopathy (HP:0200134)1.44652007
173True hermaphroditism (HP:0010459)1.43687768
174* Short middle phalanx of finger (HP:0005819)1.43625748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.68392925
2OXSR13.78372615
3EPHB13.75690542
4MET3.10521865
5STK38L2.96171440
6BCR2.60248557
7WNK42.36047773
8LATS12.21584592
9NTRK32.20065181
10DDR22.14990133
11EPHB22.10073457
12PBK2.01164387
13PKN12.01140119
14WNK31.95928218
15MAPKAPK51.92753143
16CDK191.86249612
17SIK11.86105446
18WNK11.80181141
19LATS21.77694933
20CSNK1A1L1.75642926
21MARK11.72886153
22MKNK21.71969931
23EPHA41.63489841
24MKNK11.63321544
25NTRK11.62823905
26ROCK21.54328664
27MAP3K41.52928919
28LIMK11.50037183
29NEK61.42922993
30CSNK1G11.41739400
31PLK41.36884900
32CSNK1G31.36249728
33STK241.34339636
34TGFBR11.34028721
35EPHA31.30826757
36CAMK2B1.30040418
37PRPF4B1.28394107
38MINK11.27260437
39ICK1.26199361
40TYRO31.24730378
41MAPK151.24515182
42PINK11.24095529
43EPHA21.19421262
44MST41.19187784
45* FGFR11.18578704
46TTK1.16555529
47SGK4941.14868318
48SGK2231.14868318
49PDGFRB1.12119403
50ERBB41.10740058
51FER1.09075129
52TNIK1.06926135
53CSNK1G21.06166742
54LMTK21.06088490
55MST1R1.04022078
56SGK21.03767169
57PRKCG1.03032503
58CAMK2G1.02870884
59BMX1.01831280
60DMPK1.01463598
61NLK1.00278466
62CAMK2D0.97262148
63ERBB20.96091262
64UHMK10.95722841
65PAK30.94920826
66PRKD10.94657624
67DYRK1A0.94586554
68PAK60.93434236
69PLK30.92850866
70GSK3A0.90863546
71WEE10.90406777
72MAP3K20.88794342
73CAMK1G0.87635687
74PIK3CA0.86428818
75MAP3K100.86109468
76BRSK20.85517783
77BRD40.84914652
78PHKG10.84783894
79PHKG20.84783894
80MAP3K90.84327012
81BMPR1B0.84093812
82PTK20.82779768
83FGR0.79348520
84PLK20.79196536
85CLK10.78821432
86ZAK0.77817169
87RIPK10.77625830
88PRKCE0.76976903
89PASK0.76245607
90PNCK0.74832926
91MARK20.74148633
92NTRK20.70884800
93PDGFRA0.70060458
94ROCK10.69240370
95BUB10.67373691
96CDC70.67133070
97MAP2K40.66280769
98PRKCQ0.64223651
99CDK30.62589563
100MAP2K20.61579850
101DYRK20.61355014
102NME10.60408508
103NUAK10.59567076
104FGFR40.59319456
105FGFR30.58764423
106MAPK100.57748345
107CAMK10.57647143
108CSNK1E0.57040029
109BRSK10.56743416
110CAMK1D0.55251276
111TSSK60.54951333
112SGK30.54547944
113CSNK1D0.54303056
114CAMK2A0.53913818
115STK30.53735813
116SGK10.53467380
117PRKD30.53024400
118ACVR1B0.52520138
119INSRR0.52024511
120MAPK70.50784120
121DAPK20.50592114
122PRKDC0.50279448
123FYN0.50267986
124PLK10.49919811
125CDK50.49783141
126* FGFR20.48774921
127PRKCH0.48159934
128PAK20.47945936
129CDK140.47938054
130CSNK1A10.47101309
131MELK0.46455372
132ALK0.45246154
133PTK60.45053129
134TRPM70.44966174
135LRRK20.44885093
136CDK120.44183715
137GSK3B0.42444850
138TAF10.42142110
139PDPK10.41960395
140RPS6KA30.41558094
141MAP3K70.40742017
142VRK10.40480895
143CDK150.38867807
144CASK0.38011859
145PRKACB0.37635954
146KSR20.36885394
147SRC0.35967220
148STK110.35904182
149INSR0.34854303
150CDK180.34184236
151PRKCZ0.33525670
152ILK0.33490450
153PRKG10.33044360

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80623885
2Steroid biosynthesis_Homo sapiens_hsa001003.42089612
3Fatty acid elongation_Homo sapiens_hsa000623.39811832
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06491913
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95519208
6Nicotine addiction_Homo sapiens_hsa050332.51653682
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39680613
8Ether lipid metabolism_Homo sapiens_hsa005652.16098406
9Basal cell carcinoma_Homo sapiens_hsa052172.13194291
10Histidine metabolism_Homo sapiens_hsa003401.99298396
11Sulfur metabolism_Homo sapiens_hsa009201.97199772
12Hedgehog signaling pathway_Homo sapiens_hsa043401.88127314
13Axon guidance_Homo sapiens_hsa043601.81936682
14ECM-receptor interaction_Homo sapiens_hsa045121.81350641
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71188415
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64967430
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62107802
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61991382
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.58897186
20Vitamin B6 metabolism_Homo sapiens_hsa007501.55901499
21Butanoate metabolism_Homo sapiens_hsa006501.52659186
22Fatty acid metabolism_Homo sapiens_hsa012121.50912688
23Circadian entrainment_Homo sapiens_hsa047131.43422511
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41975534
25Amphetamine addiction_Homo sapiens_hsa050311.39952521
26Hippo signaling pathway_Homo sapiens_hsa043901.37825152
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.36180448
28Fatty acid biosynthesis_Homo sapiens_hsa000611.36049049
29Tight junction_Homo sapiens_hsa045301.32099958
30Chemical carcinogenesis_Homo sapiens_hsa052041.29191923
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26929317
32Mineral absorption_Homo sapiens_hsa049781.26381499
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26034282
34Insulin secretion_Homo sapiens_hsa049111.19698380
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16014168
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15194118
37Sphingolipid metabolism_Homo sapiens_hsa006001.11997095
38Renal cell carcinoma_Homo sapiens_hsa052111.10317517
39Taste transduction_Homo sapiens_hsa047421.08978986
40Linoleic acid metabolism_Homo sapiens_hsa005911.05623623
41Morphine addiction_Homo sapiens_hsa050321.03211685
42Arginine and proline metabolism_Homo sapiens_hsa003301.03126657
43Complement and coagulation cascades_Homo sapiens_hsa046101.01712625
44Bile secretion_Homo sapiens_hsa049760.99663641
45Retinol metabolism_Homo sapiens_hsa008300.99640870
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98997855
47Peroxisome_Homo sapiens_hsa041460.98637528
48Glutathione metabolism_Homo sapiens_hsa004800.98511272
49Phototransduction_Homo sapiens_hsa047440.98130009
50Fatty acid degradation_Homo sapiens_hsa000710.97455447
51Circadian rhythm_Homo sapiens_hsa047100.94908130
52PPAR signaling pathway_Homo sapiens_hsa033200.93536131
53Protein digestion and absorption_Homo sapiens_hsa049740.92999160
54Dopaminergic synapse_Homo sapiens_hsa047280.91507123
55Synaptic vesicle cycle_Homo sapiens_hsa047210.91428889
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89890167
57Wnt signaling pathway_Homo sapiens_hsa043100.89279078
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89260867
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87827910
60Propanoate metabolism_Homo sapiens_hsa006400.86901749
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85793960
62Vitamin digestion and absorption_Homo sapiens_hsa049770.84279555
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84194376
64Cardiac muscle contraction_Homo sapiens_hsa042600.82913427
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81892207
66TGF-beta signaling pathway_Homo sapiens_hsa043500.81393729
67Tyrosine metabolism_Homo sapiens_hsa003500.81199798
68Tryptophan metabolism_Homo sapiens_hsa003800.81193027
69Focal adhesion_Homo sapiens_hsa045100.81164920
70Long-term potentiation_Homo sapiens_hsa047200.81113757
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80875659
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80258886
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.79314432
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77260348
75Ovarian steroidogenesis_Homo sapiens_hsa049130.77136627
76Proteoglycans in cancer_Homo sapiens_hsa052050.76805546
77Gap junction_Homo sapiens_hsa045400.76614350
78Arginine biosynthesis_Homo sapiens_hsa002200.74163382
79Melanogenesis_Homo sapiens_hsa049160.72904512
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72887004
81Renin secretion_Homo sapiens_hsa049240.71419224
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71173274
83Lysine degradation_Homo sapiens_hsa003100.70811238
84beta-Alanine metabolism_Homo sapiens_hsa004100.69457673
85Oocyte meiosis_Homo sapiens_hsa041140.65076730
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64996469
87Folate biosynthesis_Homo sapiens_hsa007900.64857240
88Dorso-ventral axis formation_Homo sapiens_hsa043200.64637857
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64618447
90Adherens junction_Homo sapiens_hsa045200.63955780
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.62619887
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.62242605
93Ribosome_Homo sapiens_hsa030100.61962483
94Calcium signaling pathway_Homo sapiens_hsa040200.61383827
95ABC transporters_Homo sapiens_hsa020100.60862205
96Amoebiasis_Homo sapiens_hsa051460.59897998
97Arachidonic acid metabolism_Homo sapiens_hsa005900.59576588
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59269393
99Huntingtons disease_Homo sapiens_hsa050160.56881717
100Glutamatergic synapse_Homo sapiens_hsa047240.56848523
101Gastric acid secretion_Homo sapiens_hsa049710.55536234
102Caffeine metabolism_Homo sapiens_hsa002320.55270351
103Cocaine addiction_Homo sapiens_hsa050300.54873720
104GABAergic synapse_Homo sapiens_hsa047270.54035348
105* Ras signaling pathway_Homo sapiens_hsa040140.53026683
106* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52980411
107ErbB signaling pathway_Homo sapiens_hsa040120.51368657
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51042105
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.48348394
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.48216592
111* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47811350
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.47811268
113Oxidative phosphorylation_Homo sapiens_hsa001900.47749355
114Olfactory transduction_Homo sapiens_hsa047400.47022558
115Pyruvate metabolism_Homo sapiens_hsa006200.46162816
116* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45088079
117mRNA surveillance pathway_Homo sapiens_hsa030150.44718039
118Fat digestion and absorption_Homo sapiens_hsa049750.44037536
119* Pathways in cancer_Homo sapiens_hsa052000.43565731
120Lysosome_Homo sapiens_hsa041420.43433889
121Notch signaling pathway_Homo sapiens_hsa043300.43431629
122Long-term depression_Homo sapiens_hsa047300.43161784
123Pancreatic secretion_Homo sapiens_hsa049720.39488063
124* Endocytosis_Homo sapiens_hsa041440.39325679
125Salivary secretion_Homo sapiens_hsa049700.39057454
126* Rap1 signaling pathway_Homo sapiens_hsa040150.38273489
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37341900
128Thyroid hormone synthesis_Homo sapiens_hsa049180.34730188
129Phenylalanine metabolism_Homo sapiens_hsa003600.34103424
130Choline metabolism in cancer_Homo sapiens_hsa052310.33926625
131cAMP signaling pathway_Homo sapiens_hsa040240.33551816
132Serotonergic synapse_Homo sapiens_hsa047260.32905816
133Melanoma_Homo sapiens_hsa052180.32778696
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32638570
135Malaria_Homo sapiens_hsa051440.32481594
136Dilated cardiomyopathy_Homo sapiens_hsa054140.32362692

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