FGFBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte proliferation (GO:0043616)8.36461698
2establishment of skin barrier (GO:0061436)7.80252542
3regulation of water loss via skin (GO:0033561)7.74811210
4keratinocyte development (GO:0003334)6.89659352
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.51575601
6surfactant homeostasis (GO:0043129)6.45280791
7viral transcription (GO:0019083)6.36327456
8negative regulation of keratinocyte proliferation (GO:0010839)6.29286190
9ribosomal small subunit biogenesis (GO:0042274)6.26303718
10keratinization (GO:0031424)6.04791038
11translational termination (GO:0006415)6.02985560
12fatty acid elongation (GO:0030497)6.00695225
13gap junction assembly (GO:0016264)5.74302052
14sphingoid metabolic process (GO:0046519)5.67619759
15regulation of hair follicle development (GO:0051797)5.57429445
16keratinocyte differentiation (GO:0030216)5.42991071
17multicellular organismal water homeostasis (GO:0050891)5.39621165
18regulation of phospholipase A2 activity (GO:0032429)5.36446942
19chemical homeostasis within a tissue (GO:0048875)5.34593628
20interferon-gamma secretion (GO:0072643)5.25020191
21regulation of chemokine secretion (GO:0090196)5.03053980
22long-chain fatty acid biosynthetic process (GO:0042759)5.02348349
23dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.93670845
24cell adhesion mediated by integrin (GO:0033627)4.88669612
25translational elongation (GO:0006414)4.87834542
26viral life cycle (GO:0019058)4.87550961
27protein targeting to ER (GO:0045047)4.83178827
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79626394
29sphingosine metabolic process (GO:0006670)4.70322432
30hair cycle (GO:0042633)4.68526796
31molting cycle (GO:0042303)4.68526796
32positive regulation of hair cycle (GO:0042635)4.68525909
33positive regulation of hair follicle development (GO:0051798)4.68525909
34cotranslational protein targeting to membrane (GO:0006613)4.68414995
35maturation of SSU-rRNA (GO:0030490)4.68299658
36diol metabolic process (GO:0034311)4.66768783
37ribosomal small subunit assembly (GO:0000028)4.62963318
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.61796390
39regulation of transforming growth factor beta2 production (GO:0032909)4.55369968
40cellular protein complex disassembly (GO:0043624)4.54660883
41protein localization to endoplasmic reticulum (GO:0070972)4.52611261
42primary alcohol catabolic process (GO:0034310)4.52578672
43negative regulation of chondrocyte differentiation (GO:0032331)4.52050751
44water homeostasis (GO:0030104)4.47984986
45intermediate filament organization (GO:0045109)4.42525505
46polarized epithelial cell differentiation (GO:0030859)4.35552516
47epidermis development (GO:0008544)4.33040634
48epidermal cell differentiation (GO:0009913)4.27123511
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25424552
50epithelial cell differentiation involved in prostate gland development (GO:0060742)4.17038701
51positive regulation of epidermal cell differentiation (GO:0045606)4.14257895
52ribosomal large subunit biogenesis (GO:0042273)4.11259824
53intestinal epithelial cell development (GO:0060576)4.10514209
54protein localization to endosome (GO:0036010)4.10102096
55regulation of hair cycle (GO:0042634)3.98765538
56hypotonic response (GO:0006971)3.95017232
57regulation of keratinocyte proliferation (GO:0010837)3.93891711
58membrane raft organization (GO:0031579)3.88558753
59mesodermal cell differentiation (GO:0048333)3.85476383
60ethanol metabolic process (GO:0006067)3.81879512
61translational initiation (GO:0006413)3.80308129
62positive regulation of epidermis development (GO:0045684)3.76161129
63protein complex disassembly (GO:0043241)3.73727927
64positive regulation of chemokine secretion (GO:0090197)3.63516215
65lateral sprouting from an epithelium (GO:0060601)3.63481383
66eyelid development in camera-type eye (GO:0061029)3.59787375
67ectoderm development (GO:0007398)3.59660029
68cell junction assembly (GO:0034329)3.55855053
69retinal metabolic process (GO:0042574)3.55265945
70protein targeting to membrane (GO:0006612)3.49455082
71regulation of ruffle assembly (GO:1900027)3.44578107
72skin morphogenesis (GO:0043589)3.42641649
73macromolecular complex disassembly (GO:0032984)3.42477392
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.42130920
75regulation of cell proliferation involved in kidney development (GO:1901722)3.40115940
76cell junction organization (GO:0034330)3.38091652
77diterpenoid biosynthetic process (GO:0016102)3.37223520
78regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.36224768
79endodermal cell differentiation (GO:0035987)3.26708391
80detection of bacterium (GO:0016045)3.26550393
81regulation of metalloenzyme activity (GO:0048552)3.24984082
82positive regulation of interleukin-8 secretion (GO:2000484)3.23523450
83epithelial cell-cell adhesion (GO:0090136)3.20333895
84terpenoid biosynthetic process (GO:0016114)3.19996458
85cell-substrate junction assembly (GO:0007044)3.19733818
86regulation of keratinocyte differentiation (GO:0045616)3.19348372
87ventricular cardiac muscle cell action potential (GO:0086005)3.18983658
88long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.16970675
89one-carbon compound transport (GO:0019755)3.16551453
90peptide cross-linking (GO:0018149)3.16156964
91regulation of epidermis development (GO:0045682)3.15561828
92glutathione derivative biosynthetic process (GO:1901687)3.12484788
93glutathione derivative metabolic process (GO:1901685)3.12484788
94regulation of epidermal cell differentiation (GO:0045604)3.11104502
95cytoskeletal anchoring at plasma membrane (GO:0007016)3.09853389
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.09831075
97negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.09494185
98regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.08435759
99glucosamine-containing compound catabolic process (GO:1901072)3.07160416
100negative regulation of cartilage development (GO:0061037)3.02649208
101regulation of interleukin-8 secretion (GO:2000482)3.02467789
102cell-substrate adherens junction assembly (GO:0007045)2.99250033
103focal adhesion assembly (GO:0048041)2.99250033
104atrioventricular valve morphogenesis (GO:0003181)2.96748332
105positive regulation of protein export from nucleus (GO:0046827)2.95934363
106L-serine transport (GO:0015825)2.95327408
107negative regulation of cell fate commitment (GO:0010454)2.94886466
108retinol metabolic process (GO:0042572)2.90517339
109fatty-acyl-CoA metabolic process (GO:0035337)2.90260633
110positive regulation of hormone metabolic process (GO:0032352)2.88620097
111gland morphogenesis (GO:0022612)2.87356096
112intermediate filament cytoskeleton organization (GO:0045104)2.84948783
113wound healing (GO:0042060)2.84522145
114calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84024347
115negative regulation of epidermis development (GO:0045683)2.82831343
116cell differentiation involved in embryonic placenta development (GO:0060706)2.82216279
117morphogenesis of embryonic epithelium (GO:0016331)2.81792066
118tight junction assembly (GO:0070830)2.80275864
119fatty-acyl-CoA biosynthetic process (GO:0046949)2.79453831
120mammary gland epithelial cell proliferation (GO:0033598)2.78479819
121epithelium development (GO:0060429)2.77636604
122cyclooxygenase pathway (GO:0019371)2.77604819
123negative regulation of epidermal cell differentiation (GO:0045605)2.76953122
124cardiac right ventricle morphogenesis (GO:0003215)2.73373510
125regulation of cardioblast differentiation (GO:0051890)2.73368733
126regulation of glomerular filtration (GO:0003093)2.73261875
127renal absorption (GO:0070293)2.72647272
128negative regulation of cell fate specification (GO:0009996)2.72044909
129intermediate filament-based process (GO:0045103)2.72043362
130positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.71693017
131positive regulation of vesicle fusion (GO:0031340)2.69565071
132adherens junction organization (GO:0034332)2.67862654
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67703465
134detection of other organism (GO:0098543)2.66104609
135glial cell proliferation (GO:0014009)2.65928526
136renal system development (GO:0072001)2.65903530
137renal filtration (GO:0097205)2.65688137
138positive regulation of positive chemotaxis (GO:0050927)2.65309219
139establishment of epithelial cell polarity (GO:0090162)2.65038170
140cellular copper ion homeostasis (GO:0006878)2.63946196
141regulation of transforming growth factor beta production (GO:0071634)2.62699218
142establishment of tissue polarity (GO:0007164)2.62423476
143establishment of planar polarity (GO:0001736)2.62423476
144positive regulation of keratinocyte differentiation (GO:0045618)2.61314529
145skin development (GO:0043588)2.61161749
146membrane budding (GO:0006900)2.61120020
147activation of Rac GTPase activity (GO:0032863)2.59324052
148protein localization to microtubule (GO:0035372)2.59068138
149epithelial cell proliferation (GO:0050673)2.58503437
150regulation of heart rate by cardiac conduction (GO:0086091)2.56780710
151mammary gland alveolus development (GO:0060749)2.56363575
152adherens junction assembly (GO:0034333)2.52405878
153COPI coating of Golgi vesicle (GO:0048205)2.52403546
154Golgi transport vesicle coating (GO:0048200)2.52403546
155negative regulation of stem cell proliferation (GO:2000647)2.51395185
156desmosome organization (GO:0002934)11.9406939
157hemidesmosome assembly (GO:0031581)10.4736723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.62252470
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.44956049
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.76087815
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.64658827
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49628572
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.44621885
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.38393201
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24669766
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12757207
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12757207
11TP63_17297297_ChIP-ChIP_HaCaT_Human16.9110577
12ZNF263_19887448_ChIP-Seq_K562_Human1.93785734
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.87507020
14CDX2_20551321_ChIP-Seq_CACO-2_Human1.82246027
15* SOX2_20726797_ChIP-Seq_SW620_Human1.67687867
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66965258
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63246112
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54135320
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53467628
20TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53033595
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.52260297
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.50913542
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48197952
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43456884
25AR_21909140_ChIP-Seq_LNCAP_Human1.42384508
26* GATA4_25053715_ChIP-Seq_YYC3_Human1.42117011
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40815361
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40450139
29GATA6_25053715_ChIP-Seq_YYC3_Human1.39721019
30RXR_22108803_ChIP-Seq_LS180_Human1.39251644
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36734334
32KLF5_25053715_ChIP-Seq_YYC3_Human1.34917451
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32188090
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.31940788
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.31284429
36* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30421873
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29601741
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28378328
39HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26570598
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.26425418
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22137918
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21016252
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18101804
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.17709617
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14313421
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14053247
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.11579613
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09498038
49* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05681147
50RACK7_27058665_Chip-Seq_MCF-7_Human1.05278507
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05024750
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01942427
53CJUN_26792858_Chip-Seq_BT549_Human1.01594045
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00405503
55ATF3_27146783_Chip-Seq_COLON_Human0.98457022
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97292454
57VDR_22108803_ChIP-Seq_LS180_Human0.97056761
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96884508
59TP63_23658742_ChIP-Seq_EP156T_Human0.95748486
60TP53_18474530_ChIP-ChIP_U2OS_Human0.95128040
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94825654
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94130580
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94130580
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94130580
65* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93890287
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92675979
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92201011
68* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91858990
69* TP63_22573176_ChIP-Seq_HFKS_Human0.91248780
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90669664
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90287685
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89027411
73TP53_20018659_ChIP-ChIP_R1E_Mouse0.88900255
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88861269
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88784379
76CLOCK_20551151_ChIP-Seq_293T_Human0.88292543
77AHR_22903824_ChIP-Seq_MCF-7_Human0.86039817
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84500955
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82983416
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82879894
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82464172
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81122059
83TP53_16413492_ChIP-PET_HCT116_Human0.80500869
84* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79637694
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79592907
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.78781303
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78293013
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78037471
89TP53_22127205_ChIP-Seq_IMR90_Human0.76264055
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76036627
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75958475
92* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74877555
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74176105
94PPARA_22158963_ChIP-Seq_LIVER_Mouse0.73842076
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72942313
96MYC_19079543_ChIP-ChIP_MESCs_Mouse0.72901269
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72898513
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72008665
99EGR1_19032775_ChIP-ChIP_M12_Human0.71953732
100* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.71723083
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.71301841
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.70175176
103* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.69329062
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.68527964
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.68527964
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68384421
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.67920362
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67079657
109* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.67003396
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66036158
111LXR_22292898_ChIP-Seq_THP-1_Human0.65557109
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.62289701
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.62188972
114CHD1_26751641_Chip-Seq_LNCaP_Human0.61751683
115* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.60806528
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60295147
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59864841
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59701405
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59646123
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.59309772
121* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.59017952
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.58283052
123BRD4_25478319_ChIP-Seq_HGPS_Human0.57646495
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.57249668
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.56408305
126CEBPB_22108803_ChIP-Seq_LS180_Human0.55850663
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.55577984
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.52411064
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.50728249
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.49892372
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49433645
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.49254728
133KAP1_27257070_Chip-Seq_ESCs_Mouse0.48712820
134ELF5_23300383_ChIP-Seq_T47D_Human0.48014844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.97010774
2MP0010234_abnormal_vibrissa_follicle4.94992384
3MP0003941_abnormal_skin_development4.54987102
4MP0002254_reproductive_system_inflammat4.39393874
5MP0004381_abnormal_hair_follicle3.77534569
6MP0005501_abnormal_skin_physiology3.62891917
7MP0000383_abnormal_hair_follicle3.21803128
8MP0009379_abnormal_foot_pigmentation3.10528684
9MP0002060_abnormal_skin_morphology3.04483795
10MP0005275_abnormal_skin_tensile2.99292482
11MP0003453_abnormal_keratinocyte_physiol2.96882844
12MP0010678_abnormal_skin_adnexa2.96344399
13MP0002098_abnormal_vibrissa_morphology2.95062279
14MP0001216_abnormal_epidermal_layer2.93619100
15MP0000467_abnormal_esophagus_morphology2.76728462
16MP0000579_abnormal_nail_morphology2.72900387
17MP0003011_delayed_dark_adaptation2.44323602
18MP0001346_abnormal_lacrimal_gland2.43665739
19MP0010771_integument_phenotype2.42593877
20MP0000762_abnormal_tongue_morphology2.41649129
21MP0008789_abnormal_olfactory_epithelium2.40309699
22MP0000566_synostosis2.37824464
23MP0000537_abnormal_urethra_morphology2.24932665
24MP0000647_abnormal_sebaceous_gland2.19787679
25MP0008260_abnormal_autophagy2.16209996
26MP0003566_abnormal_cell_adhesion2.07592840
27MP0009053_abnormal_anal_canal2.06609485
28MP0000377_abnormal_hair_follicle2.05263702
29MP0002009_preneoplasia2.01130047
30MP0005394_taste/olfaction_phenotype1.90214727
31MP0005499_abnormal_olfactory_system1.90214727
32MP0002234_abnormal_pharynx_morphology1.84211143
33MP0000427_abnormal_hair_cycle1.77830133
34MP0003705_abnormal_hypodermis_morpholog1.76113474
35MP0004947_skin_inflammation1.73193303
36MP0010352_gastrointestinal_tract_polyps1.65707882
37MP0003315_abnormal_perineum_morphology1.59986226
38MP0010030_abnormal_orbit_morphology1.56305950
39MP0001849_ear_inflammation1.45774179
40MP0004264_abnormal_extraembryonic_tissu1.39251256
41MP0001191_abnormal_skin_condition1.38698327
42MP0003950_abnormal_plasma_membrane1.30224342
43MP0003191_abnormal_cellular_cholesterol1.26010250
44MP0005360_urolithiasis1.23868153
45MP0009931_abnormal_skin_appearance1.23269012
46MP0002233_abnormal_nose_morphology1.21995255
47MP0003136_yellow_coat_color1.21369551
48MP0005023_abnormal_wound_healing1.19980892
49MP0004272_abnormal_basement_membrane1.17496619
50MP0004019_abnormal_vitamin_homeostasis1.10284132
51MP0000462_abnormal_digestive_system1.09190368
52MP0004185_abnormal_adipocyte_glucose1.07142055
53MP0005367_renal/urinary_system_phenotyp1.06584071
54MP0000516_abnormal_urinary_system1.06584071
55MP0001340_abnormal_eyelid_morphology1.02163365
56MP0004885_abnormal_endolymph1.01546369
57MP0002132_abnormal_respiratory_system1.01250163
58MP0008004_abnormal_stomach_pH1.00572581
59MP0000367_abnormal_coat/_hair0.98416393
60MP0000613_abnormal_salivary_gland0.94843334
61MP0003283_abnormal_digestive_organ0.93445198
62MP0002277_abnormal_respiratory_mucosa0.90200931
63MP0002877_abnormal_melanocyte_morpholog0.88968997
64MP0005451_abnormal_body_composition0.88628291
65MP0000858_altered_metastatic_potential0.86483319
66MP0001243_abnormal_dermal_layer0.86318974
67MP0000627_abnormal_mammary_gland0.84941483
68MP0009384_cardiac_valve_regurgitation0.82558223
69MP0000470_abnormal_stomach_morphology0.81799835
70MP0004782_abnormal_surfactant_physiolog0.81772587
71MP0005083_abnormal_biliary_tract0.81000083
72MP0000538_abnormal_urinary_bladder0.78243030
73MP0001851_eye_inflammation0.77764679
74MP0000678_abnormal_parathyroid_gland0.77065857
75MP0005257_abnormal_intraocular_pressure0.75738431
76MP0003828_pulmonary_edema0.75461179
77MP0010155_abnormal_intestine_physiology0.75022844
78MP0009780_abnormal_chondrocyte_physiolo0.74482873
79MP0002249_abnormal_larynx_morphology0.73969778
80MP0003755_abnormal_palate_morphology0.73380837
81MP0001984_abnormal_olfaction0.72282177
82MP0002282_abnormal_trachea_morphology0.72227817
83MP0002006_tumorigenesis0.71433051
84MP0003786_premature_aging0.71259531
85MP0001299_abnormal_eye_distance/0.70939233
86MP0008995_early_reproductive_senescence0.70408137
87MP0000465_gastrointestinal_hemorrhage0.70085742
88MP0006054_spinal_hemorrhage0.66918902
89MP0005197_abnormal_uvea_morphology0.62593869
90MP0001666_abnormal_nutrient_absorption0.62033978
91MP0000477_abnormal_intestine_morphology0.61261862
92MP0002166_altered_tumor_susceptibility0.61204903
93MP0003329_amyloid_beta_deposits0.61061711
94MP0009840_abnormal_foam_cell0.60420965
95MP0005408_hypopigmentation0.60155561
96MP0003806_abnormal_nucleotide_metabolis0.59675338
97MP0002089_abnormal_postnatal_growth/wei0.59164496
98MP0005409_darkened_coat_color0.58574703
99MP0000372_irregular_coat_pigmentation0.58510148
100MP0005508_abnormal_skeleton_morphology0.56290751
101MP0001873_stomach_inflammation0.56029280
102MP0005193_abnormal_anterior_eye0.55650356
103MP0002111_abnormal_tail_morphology0.55470751
104MP0003045_fibrosis0.55385708
105MP0003937_abnormal_limbs/digits/tail_de0.55161291
106MP0002896_abnormal_bone_mineralization0.54770942
107MP0003938_abnormal_ear_development0.54401073
108MP0004134_abnormal_chest_morphology0.53866678
109MP0000003_abnormal_adipose_tissue0.53731767
110MP0001765_abnormal_ion_homeostasis0.53483952
111MP0002177_abnormal_outer_ear0.53185564
112MP0003300_gastrointestinal_ulcer0.50191061
113MP0000432_abnormal_head_morphology0.49388985
114MP0005075_abnormal_melanosome_morpholog0.49333050
115MP0008875_abnormal_xenobiotic_pharmacok0.48090747
116MP0003091_abnormal_cell_migration0.47753921
117MP0001784_abnormal_fluid_regulation0.46263456
118MP0010368_abnormal_lymphatic_system0.45948023
119MP0000049_abnormal_middle_ear0.45642541
120MP0002697_abnormal_eye_size0.44125800
121MP0004957_abnormal_blastocyst_morpholog0.43487459
122MP0003693_abnormal_embryo_hatching0.43440350
123MP0005164_abnormal_response_to0.42309303
124MP0002095_abnormal_skin_pigmentation0.42193823
125MP0005248_abnormal_Harderian_gland0.41679476
126MP0005165_increased_susceptibility_to0.41498707
127MP0001919_abnormal_reproductive_system0.41148403
128MP0000750_abnormal_muscle_regeneration0.40819256
129MP0005621_abnormal_cell_physiology0.40579803
130MP0004197_abnormal_fetal_growth/weight/0.40396826
131MP0000733_abnormal_muscle_development0.39915842
132MP0008932_abnormal_embryonic_tissue0.37733850
133MP0008007_abnormal_cellular_replicative0.37298477

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)7.30111530
2Onycholysis (HP:0001806)6.94396778
3Plantar hyperkeratosis (HP:0007556)6.22720214
4Milia (HP:0001056)6.13985464
5Lip pit (HP:0100267)6.07176871
6Woolly hair (HP:0002224)5.95032310
7Right ventricular cardiomyopathy (HP:0011663)5.79615396
8Hypotrichosis (HP:0001006)5.17313212
9Oral leukoplakia (HP:0002745)5.10154442
10Palmoplantar hyperkeratosis (HP:0000972)4.61368678
11Palmar hyperkeratosis (HP:0010765)4.42582012
12Parakeratosis (HP:0001036)4.27490581
13Ridged nail (HP:0001807)4.18634707
14Atrophic scars (HP:0001075)4.13236197
15Congenital ichthyosiform erythroderma (HP:0007431)4.06078316
16Abnormal blistering of the skin (HP:0008066)4.00663077
17Abnormal hemoglobin (HP:0011902)3.99664927
18Nail dystrophy (HP:0008404)3.86831305
19Selective tooth agenesis (HP:0001592)3.85220210
20Thick nail (HP:0001805)3.77857785
21Alopecia of scalp (HP:0002293)3.67453397
22Pili torti (HP:0003777)3.64875050
23Esophageal atresia (HP:0002032)3.60006063
24Abnormality of nail color (HP:0100643)3.53783091
25Curly hair (HP:0002212)3.39026179
26Pterygium (HP:0001059)3.30504024
27Popliteal pterygium (HP:0009756)3.25862945
28Abnormality of cells of the erythroid lineage (HP:0012130)3.25612076
29Aplasia cutis congenita (HP:0001057)3.23033367
30Absent eyelashes (HP:0000561)3.21432485
31Abnormality of secondary sexual hair (HP:0009888)3.10664319
32Abnormality of the axillary hair (HP:0100134)3.10664319
33Sparse eyelashes (HP:0000653)3.10474946
34Reticulocytopenia (HP:0001896)3.05372356
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.04683384
36Natal tooth (HP:0000695)3.01005394
37Ankyloglossia (HP:0010296)2.99656312
38Down-sloping shoulders (HP:0200021)2.98400294
39Stenosis of the external auditory canal (HP:0000402)2.86680523
40Distal lower limb muscle weakness (HP:0009053)2.85491986
41Dry hair (HP:0011359)2.80239509
42Congenital, generalized hypertrichosis (HP:0004540)2.72745336
43Sparse scalp hair (HP:0002209)2.70196013
44Abnormal number of erythroid precursors (HP:0012131)2.66647831
45Pustule (HP:0200039)2.66080646
46Erythema (HP:0010783)2.63866731
47Fragile skin (HP:0001030)2.62880609
48Macrocytic anemia (HP:0001972)2.60106199
49Acanthosis nigricans (HP:0000956)2.59475776
50Hypoplasia of dental enamel (HP:0006297)2.57947747
51Advanced eruption of teeth (HP:0006288)2.50571326
52Ventricular tachycardia (HP:0004756)2.47593366
53Abnormality of the 2nd finger (HP:0004100)2.43803539
54Carious teeth (HP:0000670)2.42328540
55Hypoplastic labia majora (HP:0000059)2.41995642
56Hypohidrosis (HP:0000966)2.41169071
57Abnormality of oral frenula (HP:0000190)2.37331286
58Symphalangism affecting the phalanges of the hand (HP:0009773)2.36743490
59Hyperhidrosis (HP:0000975)2.36129838
60Bifid scrotum (HP:0000048)2.35637800
61Hypodontia (HP:0000668)2.32954264
62Ectropion (HP:0000656)2.31832712
63Erythroderma (HP:0001019)2.31111569
64Corneal erosion (HP:0200020)2.29313462
65Xerostomia (HP:0000217)2.28714649
66Abnormal hair laboratory examination (HP:0003328)2.28341680
67Abnormality of the distal phalanges of the toes (HP:0010182)2.27663025
68Abnormality of the salivary glands (HP:0010286)2.23510091
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.21323067
70Blepharitis (HP:0000498)2.19638209
71Abnormality of the labia majora (HP:0012881)2.18873610
72Pallor (HP:0000980)2.17094306
73Palmoplantar keratoderma (HP:0000982)2.15756480
74Abnormality of the fingernails (HP:0001231)2.14236209
75Trismus (HP:0000211)2.12615143
76Breast hypoplasia (HP:0003187)2.10507097
77Multifactorial inheritance (HP:0001426)2.10240284
78Septate vagina (HP:0001153)2.06211137
79Epidermoid cyst (HP:0200040)2.05719693
80Dehydration (HP:0001944)2.05021373
81Abnormality of the neuromuscular junction (HP:0003398)2.04871680
82Fatigable weakness (HP:0003473)2.04871680
83Premature loss of primary teeth (HP:0006323)2.04833021
84Split foot (HP:0001839)2.03711185
85Flat acetabular roof (HP:0003180)2.03059460
86Pruritus (HP:0000989)2.02753234
87Aplasia involving bones of the upper limbs (HP:0009823)1.99658048
88Aplasia of the phalanges of the hand (HP:0009802)1.99658048
89Aplasia involving bones of the extremities (HP:0009825)1.99658048
90Posterior subcapsular cataract (HP:0007787)1.98141758
91Abnormality of the gastric mucosa (HP:0004295)1.97315894
92Absent hair (HP:0002298)1.96830474
93Abnormality of placental membranes (HP:0011409)1.94289123
94Amniotic constriction ring (HP:0009775)1.94289123
95Nasolacrimal duct obstruction (HP:0000579)1.91908875
96Abnormality of the 1st metacarpal (HP:0010009)1.90753436
97Autoamputation (HP:0001218)1.90110283
98Absent eyebrow (HP:0002223)1.89630124
99Abnormality of the middle phalanges of the toes (HP:0010183)1.88752790
100Autoimmune hemolytic anemia (HP:0001890)1.86247455
101Stomatitis (HP:0010280)1.86042761
102Concave nail (HP:0001598)1.85715491
103Hoarse voice (HP:0001609)1.85376753
104Laryngomalacia (HP:0001601)1.85294174
105Skin ulcer (HP:0200042)1.85178823
106Neonatal short-limb short stature (HP:0008921)1.84470301
107Vertebral hypoplasia (HP:0008417)1.82546088
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82546088
109Labial hypoplasia (HP:0000066)1.82403315
110Cheilitis (HP:0100825)1.82376498
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.81208111
112Anhidrosis (HP:0000970)1.80157820
113Oligodontia (HP:0000677)1.78163010
114Axonal loss (HP:0003447)1.78083085
115Gangrene (HP:0100758)1.76577328
116Anonychia (HP:0001798)1.76250220
117Squamous cell carcinoma (HP:0002860)1.76226588
118Hyporeflexia of lower limbs (HP:0002600)1.73987308
119Hypoplastic female external genitalia (HP:0012815)1.73155896
120Increased IgE level (HP:0003212)1.73113871
121Abnormality of the dental root (HP:0006486)1.72983993
122Taurodontia (HP:0000679)1.72983993
123Abnormality of permanent molar morphology (HP:0011071)1.72983993
124Gastrointestinal atresia (HP:0002589)1.72771266
125Cupped ear (HP:0000378)1.72667050
126Ventricular fibrillation (HP:0001663)1.71509890
127Short hallux (HP:0010109)1.70348885
128Abnormalities of placenta or umbilical cord (HP:0001194)1.68470669
129Amelogenesis imperfecta (HP:0000705)1.66781995
130Neonatal onset (HP:0003623)1.61424363
131Short nail (HP:0001799)1.60578420
132Neurofibrillary tangles (HP:0002185)1.59650880
133Hypoplasia of the uterus (HP:0000013)1.58371627
134Ureteral stenosis (HP:0000071)1.56853259
135Abnormality of molar morphology (HP:0011070)1.56799357
136Abnormality of molar (HP:0011077)1.56799357
137Corneal dystrophy (HP:0001131)1.54921883
138Follicular hyperkeratosis (HP:0007502)1.53592348
139Periodontitis (HP:0000704)1.52149388
140Abnormality of the dental pulp (HP:0006479)1.48242530
141Recurrent corneal erosions (HP:0000495)1.48030989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.97578408
2EPHB24.77776945
3MST44.68239945
4EPHA23.82259863
5MAP3K33.71178257
6ARAF3.46216674
7TAOK32.93229285
8MAPKAPK32.92193096
9MAP3K22.83714206
10RPS6KB22.74317645
11FER2.73278831
12NTRK12.25456598
13SIK12.13534849
14TRPM72.12975779
15PAK41.93273705
16STK241.92227547
17MET1.88364591
18STK101.82171095
19PIM21.81935245
20MAP2K21.80138915
21FLT31.67434243
22PBK1.61164725
23ERBB31.59449467
24EPHB11.55945242
25LRRK21.55551408
26RPS6KA41.54169402
27TESK11.52658251
28PDK21.50662702
29NME11.41954351
30CDK31.41899002
31PDGFRA1.34948634
32PIK3CA1.30601144
33TRIB31.30168427
34PASK1.29122712
35MAP2K61.21112538
36KSR21.19440442
37PDK41.15209526
38PDK31.15209526
39EEF2K1.14301138
40IRAK31.13106655
41NME21.08304714
42LMTK21.06636623
43MAP3K131.04727920
44TGFBR21.04322954
45BRAF1.01457226
46MAP3K61.00313839
47PTK20.98348013
48LATS10.96310110
49RIPK10.94698901
50MAP2K10.91797439
51PTK60.88585565
52GRK10.86263187
53MAPK150.85733169
54RAF10.84926806
55SMG10.84608557
56MAPKAPK50.82141474
57AURKB0.81280285
58ILK0.81105884
59CDK60.79814200
60GRK70.77695528
61STK38L0.75167837
62BMX0.74701545
63TAOK20.73041959
64TAOK10.71778828
65FRK0.70871101
66MOS0.69614887
67PIK3CG0.68835047
68KSR10.68158854
69ERBB20.67982990
70FGFR20.66643756
71BCR0.66120514
72TSSK60.65488792
73MAPKAPK20.65416494
74ERBB40.64102482
75SIK30.64098127
76CDK120.63841038
77ZAK0.63775017
78TGFBR10.62251602
79EIF2AK20.60712599
80MAP3K140.60544684
81TNK20.58888777
82TTK0.58089098
83STK30.55682916
84LIMK10.53636151
85DYRK1B0.51118303
86MAP3K110.50379125
87PRKCI0.48528590
88PRKG20.48517945
89YES10.48118444
90PKN20.46720642
91MAP3K120.46526122
92NEK10.45562791
93RPS6KA20.44877657
94ITK0.44403364
95PDGFRB0.42804334
96ERN10.42565204
97MAP3K70.42176532
98TYK20.40325872
99MAP3K10.39759403
100AURKA0.37534618
101CSNK1D0.36461660
102ROCK20.36085409
103NEK60.35121979
104RPS6KA10.35102950
105PRPF4B0.34827663
106MAP3K90.34325333
107BMPR20.34099092
108STK380.33326878
109CSF1R0.32332858
110PRKD10.32148881
111MAP3K80.31400387
112ROCK10.31327853
113DMPK0.29092205
114RET0.28845453
115FGFR10.27397266
116CAMK2G0.26962191
117PRKD20.26311048
118MAPK70.26284901
119ADRBK10.26199641
120EPHA30.26151231
121PRKCA0.26046909
122MTOR0.25734999
123MATK0.25381245
124FGR0.24963908
125IGF1R0.22913002
126BUB10.22521516
127SRC0.21611890
128DDR20.21438762
129TTN0.20374125
130JAK30.19433153
131DYRK30.19225571
132PRKCD0.18858603
133STK390.18450083
134ABL20.17475970
135IKBKB0.17473893
136GSK3A0.17201301
137EIF2AK30.16743766
138RPS6KB10.16127679
139LATS20.16094720
140SGK30.15440300
141PHKG10.14362811
142PHKG20.14362811
143TRIM280.12778984
144AKT20.12681428

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.17427735
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.98395894
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.83139492
4Chemical carcinogenesis_Homo sapiens_hsa052043.39346592
5Fatty acid elongation_Homo sapiens_hsa000623.39080075
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.79355389
7Retinol metabolism_Homo sapiens_hsa008302.67450518
8Histidine metabolism_Homo sapiens_hsa003402.62980051
9Phenylalanine metabolism_Homo sapiens_hsa003602.58130073
10Sphingolipid metabolism_Homo sapiens_hsa006002.44541824
11Glutathione metabolism_Homo sapiens_hsa004802.37906791
12Sulfur metabolism_Homo sapiens_hsa009202.27468725
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.95938212
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93232371
15Steroid biosynthesis_Homo sapiens_hsa001001.87594866
16ErbB signaling pathway_Homo sapiens_hsa040121.78772319
17beta-Alanine metabolism_Homo sapiens_hsa004101.69165810
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68534271
19Basal cell carcinoma_Homo sapiens_hsa052171.67749873
20Arachidonic acid metabolism_Homo sapiens_hsa005901.59371683
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.58658375
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54357095
23Mineral absorption_Homo sapiens_hsa049781.50704835
24Bladder cancer_Homo sapiens_hsa052191.49171852
25ECM-receptor interaction_Homo sapiens_hsa045121.45921394
26Shigellosis_Homo sapiens_hsa051311.45665691
27Tyrosine metabolism_Homo sapiens_hsa003501.44955441
28Linoleic acid metabolism_Homo sapiens_hsa005911.41913427
29Tight junction_Homo sapiens_hsa045301.40522672
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39365557
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39041842
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35382298
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35309029
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34603650
35Fatty acid metabolism_Homo sapiens_hsa012121.34355693
36Thyroid cancer_Homo sapiens_hsa052161.28314282
37Chronic myeloid leukemia_Homo sapiens_hsa052201.26684385
38p53 signaling pathway_Homo sapiens_hsa041151.26215871
39Oxidative phosphorylation_Homo sapiens_hsa001901.23381630
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21623491
41Hippo signaling pathway_Homo sapiens_hsa043901.19482954
42Adherens junction_Homo sapiens_hsa045201.19031248
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18615580
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17959322
45Renal cell carcinoma_Homo sapiens_hsa052111.13980791
46Salmonella infection_Homo sapiens_hsa051321.13300576
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11560078
48Pancreatic cancer_Homo sapiens_hsa052121.11332127
49Galactose metabolism_Homo sapiens_hsa000521.10558983
50Prion diseases_Homo sapiens_hsa050201.09638022
51Endocytosis_Homo sapiens_hsa041441.08576033
52Fatty acid degradation_Homo sapiens_hsa000711.08417595
53Hedgehog signaling pathway_Homo sapiens_hsa043401.05453873
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02157068
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98033845
56Dilated cardiomyopathy_Homo sapiens_hsa054140.92914142
57Fructose and mannose metabolism_Homo sapiens_hsa000510.91175323
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90749165
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90033390
60Vitamin digestion and absorption_Homo sapiens_hsa049770.87890677
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85349017
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.83810289
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83420720
64Small cell lung cancer_Homo sapiens_hsa052220.82872422
65Proteoglycans in cancer_Homo sapiens_hsa052050.82624133
66Glioma_Homo sapiens_hsa052140.81306014
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80963327
68Inositol phosphate metabolism_Homo sapiens_hsa005620.79321340
69Amoebiasis_Homo sapiens_hsa051460.78833039
70Acute myeloid leukemia_Homo sapiens_hsa052210.78821312
71Insulin signaling pathway_Homo sapiens_hsa049100.78031434
72Alzheimers disease_Homo sapiens_hsa050100.77771835
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76976647
74Notch signaling pathway_Homo sapiens_hsa043300.76844151
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74036052
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72103012
77Pentose phosphate pathway_Homo sapiens_hsa000300.72036856
78Fat digestion and absorption_Homo sapiens_hsa049750.66633976
79N-Glycan biosynthesis_Homo sapiens_hsa005100.66325996
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65981576
81TGF-beta signaling pathway_Homo sapiens_hsa043500.65658907
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63858792
83Melanogenesis_Homo sapiens_hsa049160.62408600
84Parkinsons disease_Homo sapiens_hsa050120.61632861
85Axon guidance_Homo sapiens_hsa043600.58185273
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57462913
87Fatty acid biosynthesis_Homo sapiens_hsa000610.57379340
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56810845
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54536832
90Estrogen signaling pathway_Homo sapiens_hsa049150.53607453
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52713258
92PPAR signaling pathway_Homo sapiens_hsa033200.51359733
93Influenza A_Homo sapiens_hsa051640.50904810
94Arginine biosynthesis_Homo sapiens_hsa002200.50123825
95Toxoplasmosis_Homo sapiens_hsa051450.49258279
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48719226
97Hepatitis C_Homo sapiens_hsa051600.48658504
98Ether lipid metabolism_Homo sapiens_hsa005650.48243840
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46029932
100Non-small cell lung cancer_Homo sapiens_hsa052230.45101143
101Huntingtons disease_Homo sapiens_hsa050160.44145605
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44105073
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43459502
104Biosynthesis of amino acids_Homo sapiens_hsa012300.39912638
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37823667
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.37753946
107Rap1 signaling pathway_Homo sapiens_hsa040150.37502530
108MicroRNAs in cancer_Homo sapiens_hsa052060.37352679
109Prostate cancer_Homo sapiens_hsa052150.35667815
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35355032
111Vibrio cholerae infection_Homo sapiens_hsa051100.34419747
112Endometrial cancer_Homo sapiens_hsa052130.34412046
113Propanoate metabolism_Homo sapiens_hsa006400.33963660
114TNF signaling pathway_Homo sapiens_hsa046680.33878885
115Cardiac muscle contraction_Homo sapiens_hsa042600.33412872
116Bile secretion_Homo sapiens_hsa049760.33041459
117Viral carcinogenesis_Homo sapiens_hsa052030.32894063
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32685050
119Pancreatic secretion_Homo sapiens_hsa049720.32562709
120Pathways in cancer_Homo sapiens_hsa052000.32055451
121Malaria_Homo sapiens_hsa051440.32012920
122Dorso-ventral axis formation_Homo sapiens_hsa043200.30311746
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.29440028
124VEGF signaling pathway_Homo sapiens_hsa043700.29092565
125Protein digestion and absorption_Homo sapiens_hsa049740.28970007
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.28476527
127Glycerolipid metabolism_Homo sapiens_hsa005610.28118244
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.27754687
129Apoptosis_Homo sapiens_hsa042100.27422081
130HIF-1 signaling pathway_Homo sapiens_hsa040660.27279247
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27043402
132Renin secretion_Homo sapiens_hsa049240.26807744
133Peroxisome_Homo sapiens_hsa041460.26410611
134Focal adhesion_Homo sapiens_hsa045100.25169737
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24015932
136Phototransduction_Homo sapiens_hsa047440.23975675
137Wnt signaling pathway_Homo sapiens_hsa043100.23255987
138HTLV-I infection_Homo sapiens_hsa051660.22644569
139RNA polymerase_Homo sapiens_hsa030200.22625971
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21373020
141Caffeine metabolism_Homo sapiens_hsa002320.20574820
142Butanoate metabolism_Homo sapiens_hsa006500.20470494
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20015923
144GnRH signaling pathway_Homo sapiens_hsa049120.19814006
145Metabolic pathways_Homo sapiens_hsa011000.18924737
146Arginine and proline metabolism_Homo sapiens_hsa003300.18317912
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17995468
148Ovarian steroidogenesis_Homo sapiens_hsa049130.15524073
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13771253

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