FGF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.44989464
2neuron cell-cell adhesion (GO:0007158)5.11300762
3neuronal action potential propagation (GO:0019227)4.94849183
4vocalization behavior (GO:0071625)4.88078115
5presynaptic membrane assembly (GO:0097105)4.77607829
6negative regulation of synaptic transmission, GABAergic (GO:0032229)4.62582410
7nucleobase catabolic process (GO:0046113)4.54097513
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45797653
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43440289
10presynaptic membrane organization (GO:0097090)4.37144832
11synaptic vesicle exocytosis (GO:0016079)4.33871201
12protein localization to synapse (GO:0035418)4.28884221
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.26518962
14gamma-aminobutyric acid signaling pathway (GO:0007214)4.16280341
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13921156
16glutamate receptor signaling pathway (GO:0007215)4.11971039
17postsynaptic membrane organization (GO:0001941)4.08493337
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06882806
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.98641486
20regulation of glutamate receptor signaling pathway (GO:1900449)3.98260434
21neurotransmitter-gated ion channel clustering (GO:0072578)3.98042108
22behavioral response to nicotine (GO:0035095)3.97453517
23startle response (GO:0001964)3.92284659
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86987869
25neurofilament cytoskeleton organization (GO:0060052)3.81857938
26neuron-neuron synaptic transmission (GO:0007270)3.76692638
27regulation of synaptic vesicle exocytosis (GO:2000300)3.65552010
28synaptic transmission, glutamatergic (GO:0035249)3.62672675
29righting reflex (GO:0060013)3.52651217
30neurotransmitter secretion (GO:0007269)3.50899806
31glutamate secretion (GO:0014047)3.46334146
32nonmotile primary cilium assembly (GO:0035058)3.41352619
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38898793
34regulation of synaptic vesicle transport (GO:1902803)3.35044742
35retinal ganglion cell axon guidance (GO:0031290)3.33827184
36transmission of nerve impulse (GO:0019226)3.32006283
37short-term memory (GO:0007614)3.31092694
38neuron recognition (GO:0008038)3.30700921
39striatum development (GO:0021756)3.25658404
40gamma-aminobutyric acid transport (GO:0015812)3.24187394
41detection of calcium ion (GO:0005513)3.20172665
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18444710
43positive regulation of synapse assembly (GO:0051965)3.16175947
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.15432616
45cerebral cortex radially oriented cell migration (GO:0021799)3.14331709
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13754594
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12570164
48cerebellar Purkinje cell differentiation (GO:0021702)3.11491266
49synapse assembly (GO:0007416)3.11420523
50establishment of mitochondrion localization (GO:0051654)3.10168029
51serotonin receptor signaling pathway (GO:0007210)3.08764475
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08535029
53synaptic vesicle endocytosis (GO:0048488)3.07992481
54neurotransmitter transport (GO:0006836)3.07883539
55positive regulation of membrane potential (GO:0045838)3.05511148
56regulation of postsynaptic membrane potential (GO:0060078)3.04122774
57dendritic spine morphogenesis (GO:0060997)3.02849091
58regulation of synaptic transmission, GABAergic (GO:0032228)3.00735877
59retinal cone cell development (GO:0046549)3.00285208
60membrane depolarization during action potential (GO:0086010)3.00282702
61long-term memory (GO:0007616)2.97718674
62response to histamine (GO:0034776)2.97177635
63central nervous system projection neuron axonogenesis (GO:0021952)2.96176670
64negative regulation of dendrite morphogenesis (GO:0050774)2.93803597
65positive regulation of action potential (GO:0045760)2.92242894
66membrane depolarization (GO:0051899)2.89342347
67long-term synaptic potentiation (GO:0060291)2.88384138
68regulation of neurotransmitter secretion (GO:0046928)2.88120592
69cerebellar granule cell differentiation (GO:0021707)2.87631888
70mechanosensory behavior (GO:0007638)2.86785049
71behavioral response to cocaine (GO:0048148)2.85403361
72regulation of synapse maturation (GO:0090128)2.85332342
73membrane hyperpolarization (GO:0060081)2.84284737
74regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84089099
75positive regulation of gastrulation (GO:2000543)2.82170051
76limb bud formation (GO:0060174)2.80519630
77synaptic transmission (GO:0007268)2.79323526
78locomotory exploration behavior (GO:0035641)2.79013073
79synaptic vesicle docking involved in exocytosis (GO:0016081)2.77554348
80cell migration in hindbrain (GO:0021535)2.76164347
81response to pheromone (GO:0019236)2.75696264
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75538022
83regulation of synapse assembly (GO:0051963)2.74498177
84positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.73599270
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70825262
86axonal fasciculation (GO:0007413)2.70741791
87response to auditory stimulus (GO:0010996)2.70233269
88regulation of vesicle fusion (GO:0031338)2.70203016
89positive regulation of synapse maturation (GO:0090129)2.69868141
90behavioral response to ethanol (GO:0048149)2.69341327
91cochlea development (GO:0090102)2.68881257
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67301766
93learning (GO:0007612)2.66906998
94adult walking behavior (GO:0007628)2.66868440
95regulation of neurotransmitter levels (GO:0001505)2.66189538
96regulation of neurotransmitter transport (GO:0051588)2.66025498
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.65642716
98neuronal action potential (GO:0019228)2.64892567
99hippocampus development (GO:0021766)2.64805891
100regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.64324564
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64208748
102auditory behavior (GO:0031223)2.64029584
103positive regulation of meiosis (GO:0045836)2.63333568
104negative regulation of dendrite development (GO:2000171)2.63001234
105multicellular organismal signaling (GO:0035637)2.61562731
106hindbrain development (GO:0030902)2.61307095
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60958652
108regulation of neuronal synaptic plasticity (GO:0048168)2.60037862
109dendrite morphogenesis (GO:0048813)2.59812656
110synaptic vesicle maturation (GO:0016188)2.59734985
111adult behavior (GO:0030534)2.59481668
112protein localization to cilium (GO:0061512)2.59434665
113dendrite development (GO:0016358)2.59344250
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58984608
115calcium-mediated signaling using intracellular calcium source (GO:0035584)2.57348828
116innervation (GO:0060384)2.57278980
117positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57139207
118behavioral defense response (GO:0002209)2.56235455
119behavioral fear response (GO:0001662)2.56235455
120regulation of voltage-gated calcium channel activity (GO:1901385)2.56192755
121central nervous system neuron axonogenesis (GO:0021955)2.56166375
122glycosphingolipid biosynthetic process (GO:0006688)2.55930705
123exploration behavior (GO:0035640)2.55236027
124olfactory bulb development (GO:0021772)2.55040295
125somite rostral/caudal axis specification (GO:0032525)2.54552319
126neuromuscular synaptic transmission (GO:0007274)2.54395218
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.54183859
128NADH dehydrogenase complex assembly (GO:0010257)2.54183859
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54183859
130regulation of respiratory system process (GO:0044065)2.53743777
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53559976
132detection of light stimulus involved in sensory perception (GO:0050962)2.52486577
133detection of light stimulus involved in visual perception (GO:0050908)2.52486577
134inner ear receptor stereocilium organization (GO:0060122)2.52274373
135retina layer formation (GO:0010842)2.51444801
136protein complex biogenesis (GO:0070271)2.50154269
137positive regulation of mitochondrial fission (GO:0090141)2.49910362
138intraciliary transport (GO:0042073)2.49318590
139regulation of dendritic spine development (GO:0060998)2.48720700
140regulation of dendritic spine morphogenesis (GO:0061001)2.47259529
141positive regulation of dendritic spine development (GO:0060999)2.47022762
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.46203153
143anterograde axon cargo transport (GO:0008089)2.45488851
144regulation of meiosis I (GO:0060631)2.44032450
145positive regulation of meiotic cell cycle (GO:0051446)2.43826542
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.42983076
147regulation of action potential (GO:0098900)2.42337917
148C4-dicarboxylate transport (GO:0015740)2.41790287
149head development (GO:0060322)2.40690288
150protein polyglutamylation (GO:0018095)2.39926568
151synaptic transmission, cholinergic (GO:0007271)2.39334562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10329361
2GBX2_23144817_ChIP-Seq_PC3_Human4.39386119
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84262762
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75170812
5TAF15_26573619_Chip-Seq_HEK293_Human2.68240199
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62981504
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54016656
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53127023
9ZNF274_21170338_ChIP-Seq_K562_Hela2.50885849
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48386370
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.43939766
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33619693
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31441569
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28760063
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.26849152
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23482202
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23482202
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20184927
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19657630
20* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17887486
21REST_21632747_ChIP-Seq_MESCs_Mouse2.04948547
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03474253
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03162064
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98232495
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97837160
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97624456
27* P300_19829295_ChIP-Seq_ESCs_Human1.94789352
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90743391
29* CBX2_27304074_Chip-Seq_ESCs_Mouse1.88154572
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87900700
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87723565
32SMAD4_21799915_ChIP-Seq_A2780_Human1.85648581
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84443859
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83572597
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.82379298
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81419648
37IGF1R_20145208_ChIP-Seq_DFB_Human1.80071200
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71928554
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.68906614
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.66519075
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.65380256
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65273828
43VDR_22108803_ChIP-Seq_LS180_Human1.64305629
44FUS_26573619_Chip-Seq_HEK293_Human1.63588111
45AR_21572438_ChIP-Seq_LNCaP_Human1.63458395
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57351666
47DROSHA_22980978_ChIP-Seq_HELA_Human1.53868806
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52769912
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.51790841
50* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51231775
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.47997327
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.47658744
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47380459
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47065084
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46202772
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45562421
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45104067
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41127091
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.40517530
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39548807
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39141993
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38934163
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38447810
64AR_25329375_ChIP-Seq_VCAP_Human1.37844681
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36188000
66STAT3_23295773_ChIP-Seq_U87_Human1.36021429
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35664329
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.34380866
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34339431
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33423085
71P53_22387025_ChIP-Seq_ESCs_Mouse1.31326545
72CBP_20019798_ChIP-Seq_JUKART_Human1.30495502
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30495502
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30430784
75ER_23166858_ChIP-Seq_MCF-7_Human1.30161111
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27916884
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26344608
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.23771966
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.23208520
80TCF4_23295773_ChIP-Seq_U87_Human1.22822610
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22628579
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22628579
83IRF1_19129219_ChIP-ChIP_H3396_Human1.21729389
84* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20738484
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19932421
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19207548
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18507535
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.18250846
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.15244703
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14233662
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13447869
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.13024912
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12576954
94P300_18555785_Chip-Seq_ESCs_Mouse1.12477196
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.10902824
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10796104
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.10500157
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.09949467
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.09468976
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.09115908
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08759111
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08731123
103* RARB_27405468_Chip-Seq_BRAIN_Mouse1.08616297
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08312513
105* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07193666
106JUN_21703547_ChIP-Seq_K562_Human1.06850303
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06618573
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06339921
109* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06266354
110KDM2B_26808549_Chip-Seq_REH_Human1.06248601
111EWS_26573619_Chip-Seq_HEK293_Human1.06152158
112* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06001662
113BCAT_22108803_ChIP-Seq_LS180_Human1.05663582
114* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05538683
115* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04897225
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04409640
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04200734
118POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02760731
119* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99440648
120TCF4_22108803_ChIP-Seq_LS180_Human0.98769995
121* FLI1_21867929_ChIP-Seq_TH2_Mouse0.98597873
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98067352
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97919665
124TP53_22573176_ChIP-Seq_HFKS_Human0.97269544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.45648892
2MP0004859_abnormal_synaptic_plasticity3.61175676
3MP0009046_muscle_twitch3.18853806
4MP0003635_abnormal_synaptic_transmissio3.14309780
5MP0009745_abnormal_behavioral_response2.88784637
6MP0001968_abnormal_touch/_nociception2.83675062
7MP0001188_hyperpigmentation2.74887985
8MP0001486_abnormal_startle_reflex2.61037226
9MP0004270_analgesia2.60487836
10MP0002064_seizures2.60287655
11MP0001984_abnormal_olfaction2.55646302
12MP0002272_abnormal_nervous_system2.54753562
13MP0002063_abnormal_learning/memory/cond2.51622951
14MP0002735_abnormal_chemical_nociception2.48917993
15MP0002572_abnormal_emotion/affect_behav2.45947860
16MP0002734_abnormal_mechanical_nocicepti2.45536002
17MP0002736_abnormal_nociception_after2.43862321
18MP0005645_abnormal_hypothalamus_physiol2.37561511
19MP0002067_abnormal_sensory_capabilities2.22397147
20MP0006276_abnormal_autonomic_nervous2.14541864
21MP0000569_abnormal_digit_pigmentation2.05546557
22MP0002876_abnormal_thyroid_physiology2.01286813
23MP0006292_abnormal_olfactory_placode2.00067236
24MP0001501_abnormal_sleep_pattern1.99525874
25MP0001440_abnormal_grooming_behavior1.96639276
26MP0003787_abnormal_imprinting1.94465633
27MP0005646_abnormal_pituitary_gland1.93330449
28MP0002184_abnormal_innervation1.91104672
29MP0005551_abnormal_eye_electrophysiolog1.88435463
30MP0004142_abnormal_muscle_tone1.85313821
31MP0003879_abnormal_hair_cell1.84770717
32MP0005423_abnormal_somatic_nervous1.82540086
33MP0010386_abnormal_urinary_bladder1.79906277
34MP0001529_abnormal_vocalization1.78017220
35MP0001986_abnormal_taste_sensitivity1.77657581
36MP0002557_abnormal_social/conspecific_i1.75107747
37MP0001970_abnormal_pain_threshold1.74644692
38MP0003136_yellow_coat_color1.67420368
39MP0002733_abnormal_thermal_nociception1.66502419
40MP0000778_abnormal_nervous_system1.62769105
41MP0002822_catalepsy1.56182481
42MP0002234_abnormal_pharynx_morphology1.52044455
43MP0001502_abnormal_circadian_rhythm1.50505529
44MP0004145_abnormal_muscle_electrophysio1.48576244
45MP0005386_behavior/neurological_phenoty1.48490887
46MP0004924_abnormal_behavior1.48490887
47MP0005171_absent_coat_pigmentation1.47302405
48MP0002102_abnormal_ear_morphology1.47244706
49MP0004742_abnormal_vestibular_system1.46232130
50MP0003890_abnormal_embryonic-extraembry1.42282651
51MP0002638_abnormal_pupillary_reflex1.40050437
52MP0001905_abnormal_dopamine_level1.31267955
53MP0002882_abnormal_neuron_morphology1.30334519
54* MP0008569_lethality_at_weaning1.30222121
55* MP0001963_abnormal_hearing_physiology1.26831067
56MP0006072_abnormal_retinal_apoptosis1.26455107
57MP0004133_heterotaxia1.21086535
58MP0002837_dystrophic_cardiac_calcinosis1.20309499
59MP0000955_abnormal_spinal_cord1.19561034
60MP0003122_maternal_imprinting1.19108056
61MP0002752_abnormal_somatic_nervous1.18888589
62* MP0002066_abnormal_motor_capabilities/c1.18251200
63MP0004215_abnormal_myocardial_fiber1.15950227
64* MP0000026_abnormal_inner_ear1.14865617
65MP0003283_abnormal_digestive_organ1.11360677
66MP0000631_abnormal_neuroendocrine_gland1.09868399
67MP0002229_neurodegeneration1.09125998
68MP0002233_abnormal_nose_morphology1.08540253
69MP0005409_darkened_coat_color1.08465052
70MP0003119_abnormal_digestive_system1.07355239
71MP0001485_abnormal_pinna_reflex1.07005706
72MP0005379_endocrine/exocrine_gland_phen1.06239551
73MP0002163_abnormal_gland_morphology1.03376282
74* MP0000049_abnormal_middle_ear1.00681138
75MP0005253_abnormal_eye_physiology0.99407322
76MP0002938_white_spotting0.98043792
77MP0004811_abnormal_neuron_physiology0.97567874
78MP0002653_abnormal_ependyma_morphology0.96699797
79MP0005499_abnormal_olfactory_system0.93548585
80MP0005394_taste/olfaction_phenotype0.93548585
81MP0004085_abnormal_heartbeat0.93134598
82MP0004484_altered_response_of0.91602216
83MP0005187_abnormal_penis_morphology0.90477660
84MP0003183_abnormal_peptide_metabolism0.90388754
85MP0003137_abnormal_impulse_conducting0.89346732
86MP0003861_abnormal_nervous_system0.89240481
87MP0009780_abnormal_chondrocyte_physiolo0.85853377
88MP0002277_abnormal_respiratory_mucosa0.84805242
89MP0000427_abnormal_hair_cycle0.84117376
90MP0000751_myopathy0.82180615
91MP0003646_muscle_fatigue0.81967686
92MP0008260_abnormal_autophagy0.81112157
93MP0001664_abnormal_digestion0.80872379
94MP0002152_abnormal_brain_morphology0.79607138
95MP0003698_abnormal_male_reproductive0.78633378
96MP0005391_vision/eye_phenotype0.78198002
97MP0002069_abnormal_eating/drinking_beha0.77019042
98MP0002909_abnormal_adrenal_gland0.76640025
99MP0003937_abnormal_limbs/digits/tail_de0.76437059
100MP0001293_anophthalmia0.76093460
101MP0001177_atelectasis0.75289344
102MP0003195_calcinosis0.74597663
103MP0008877_abnormal_DNA_methylation0.74289422
104* MP0003755_abnormal_palate_morphology0.73999962
105MP0000015_abnormal_ear_pigmentation0.73968614
106* MP0002210_abnormal_sex_determination0.73707407
107MP0001346_abnormal_lacrimal_gland0.73548256
108MP0008789_abnormal_olfactory_epithelium0.70964523
109MP0003942_abnormal_urinary_system0.70520495
110MP0003938_abnormal_ear_development0.70507968
111MP0005195_abnormal_posterior_eye0.68485262
112* MP0000566_synostosis0.66111304
113MP0002090_abnormal_vision0.65136350
114MP0004885_abnormal_endolymph0.63943940
115MP0002751_abnormal_autonomic_nervous0.63829584
116MP0003633_abnormal_nervous_system0.62595060
117MP0002160_abnormal_reproductive_system0.62494682
118MP0005535_abnormal_body_temperature0.58513143
119MP0004043_abnormal_pH_regulation0.57736708
120MP0005310_abnormal_salivary_gland0.56546466
121MP0003631_nervous_system_phenotype0.56520297
122MP0003121_genomic_imprinting0.56081264

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.43370440
2Febrile seizures (HP:0002373)6.10237520
3Atonic seizures (HP:0010819)5.28566643
4Epileptic encephalopathy (HP:0200134)4.76136052
5Hyperventilation (HP:0002883)4.12571660
6Focal seizures (HP:0007359)4.00626916
7Absence seizures (HP:0002121)3.77748761
8Progressive cerebellar ataxia (HP:0002073)3.56510942
9Myokymia (HP:0002411)3.56152948
10Dialeptic seizures (HP:0011146)3.44276373
11Gait imbalance (HP:0002141)3.34975668
12Medial flaring of the eyebrow (HP:0010747)3.30915377
13Acute necrotizing encephalopathy (HP:0006965)3.20503878
14Congenital primary aphakia (HP:0007707)3.16340080
15Broad-based gait (HP:0002136)3.15337085
16Generalized tonic-clonic seizures (HP:0002069)3.11318672
17Abnormal hair whorl (HP:0010721)3.01539569
18Nephrogenic diabetes insipidus (HP:0009806)3.01241372
19Progressive macrocephaly (HP:0004481)2.94569475
20Congenital stationary night blindness (HP:0007642)2.92168732
21Gaze-evoked nystagmus (HP:0000640)2.91770981
22Abnormality of the labia minora (HP:0012880)2.89970972
23Abnormal mitochondria in muscle tissue (HP:0008316)2.83386810
24Intestinal atresia (HP:0011100)2.73970950
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70710490
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.70710490
27Genital tract atresia (HP:0001827)2.69230549
28Vaginal atresia (HP:0000148)2.66128090
29Visual hallucinations (HP:0002367)2.65312278
30Abnormality of the corticospinal tract (HP:0002492)2.61814802
31Pancreatic cysts (HP:0001737)2.52294186
32Mitochondrial inheritance (HP:0001427)2.52054059
33Hypothermia (HP:0002045)2.49103151
34True hermaphroditism (HP:0010459)2.48486589
35Optic disc pallor (HP:0000543)2.46626003
36Septo-optic dysplasia (HP:0100842)2.44118704
37Poor coordination (HP:0002370)2.39985173
38Acute encephalopathy (HP:0006846)2.37140452
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.37069129
40Absent/shortened dynein arms (HP:0200106)2.37069129
41Progressive inability to walk (HP:0002505)2.35528775
42Aplasia/Hypoplasia of the lens (HP:0008063)2.34078320
43Decreased central vision (HP:0007663)2.32924347
44Hypsarrhythmia (HP:0002521)2.31019052
45Absent speech (HP:0001344)2.30974873
46Congenital sensorineural hearing impairment (HP:0008527)2.30656771
47Inability to walk (HP:0002540)2.27113707
48Type II lissencephaly (HP:0007260)2.26571297
49Abnormal ciliary motility (HP:0012262)2.22477495
50Protruding tongue (HP:0010808)2.21275772
51Shawl scrotum (HP:0000049)2.21164392
52Optic nerve hypoplasia (HP:0000609)2.19667778
53Pancreatic fibrosis (HP:0100732)2.19445850
54Oligodactyly (hands) (HP:0001180)2.19255217
55Pachygyria (HP:0001302)2.18678779
56Fetal akinesia sequence (HP:0001989)2.17720261
57Drooling (HP:0002307)2.15807036
58Excessive salivation (HP:0003781)2.15807036
59Lissencephaly (HP:0001339)2.13751644
60Action tremor (HP:0002345)2.12320103
61Increased CSF lactate (HP:0002490)2.11427670
62Impaired vibration sensation in the lower limbs (HP:0002166)2.02510745
63Hyperglycinemia (HP:0002154)2.02048384
64Dysdiadochokinesis (HP:0002075)2.00417423
65Abnormality of macular pigmentation (HP:0008002)2.00128193
66Abnormality of the renal medulla (HP:0100957)1.99585303
67Molar tooth sign on MRI (HP:0002419)1.99478223
68Abnormality of midbrain morphology (HP:0002418)1.99478223
69Esotropia (HP:0000565)1.98605277
70Epileptiform EEG discharges (HP:0011182)1.96076331
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95441159
72Methylmalonic aciduria (HP:0012120)1.94433811
73Decreased circulating renin level (HP:0003351)1.94125264
74Amblyopia (HP:0000646)1.93254281
75Aplasia/Hypoplasia of the fovea (HP:0008060)1.92939051
76Hypoplasia of the fovea (HP:0007750)1.92939051
77Specific learning disability (HP:0001328)1.92778333
78Abnormal respiratory motile cilium physiology (HP:0012261)1.91557778
79Anxiety (HP:0000739)1.91345818
80Agitation (HP:0000713)1.90808642
81Abnormality of the renal cortex (HP:0011035)1.90482959
82Pheochromocytoma (HP:0002666)1.90263482
83Truncal ataxia (HP:0002078)1.87931866
84Abnormality of calcium-phosphate metabolism (HP:0100530)1.86728930
85Status epilepticus (HP:0002133)1.86382218
86Blue irides (HP:0000635)1.85991086
87Narrow forehead (HP:0000341)1.83525881
88Attenuation of retinal blood vessels (HP:0007843)1.83525065
89Abnormality of incisor morphology (HP:0011063)1.83338682
90Hemiparesis (HP:0001269)1.83249240
91Abnormal rod and cone electroretinograms (HP:0008323)1.82758763
92Postaxial hand polydactyly (HP:0001162)1.82470131
93Prolonged QT interval (HP:0001657)1.80925396
94Syncope (HP:0001279)1.79876044
95Hypomagnesemia (HP:0002917)1.79448475
96Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78971514
97Hypoplasia of the brainstem (HP:0002365)1.78971514
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.78903671
99Hepatocellular necrosis (HP:0001404)1.78494984
100Abnormality of the lower motor neuron (HP:0002366)1.78482569
101Osteomalacia (HP:0002749)1.78448258
102Occipital encephalocele (HP:0002085)1.77975011
103EEG with generalized epileptiform discharges (HP:0011198)1.77744860
104Pendular nystagmus (HP:0012043)1.76863584
105Abnormality of salivation (HP:0100755)1.75175423
106Genetic anticipation (HP:0003743)1.74946006
107Abnormal respiratory epithelium morphology (HP:0012253)1.74899675
108Abnormal respiratory motile cilium morphology (HP:0005938)1.74899675
109Limb dystonia (HP:0002451)1.74831257
110Congenital malformation of the right heart (HP:0011723)1.74509584
111Double outlet right ventricle (HP:0001719)1.74509584
112Growth hormone deficiency (HP:0000824)1.74304690
113Chronic hepatic failure (HP:0100626)1.74216074
114Left ventricular hypertrophy (HP:0001712)1.73672597
115Sleep apnea (HP:0010535)1.73559050
116Volvulus (HP:0002580)1.73230272
117Cystic liver disease (HP:0006706)1.73096029
118Fair hair (HP:0002286)1.70456484
119Nephronophthisis (HP:0000090)1.70360125
120Ulnar claw (HP:0001178)1.70151573
121Renal cortical cysts (HP:0000803)1.69955445
122Abnormal eating behavior (HP:0100738)1.69851406
123Poor suck (HP:0002033)1.69040455
124Patellar aplasia (HP:0006443)1.68997004
125Polyphagia (HP:0002591)1.67721357
126Thyroid-stimulating hormone excess (HP:0002925)1.67579841
127Generalized hypopigmentation of hair (HP:0011358)1.67318390
128Retinal dysplasia (HP:0007973)1.67306942
129Widely spaced teeth (HP:0000687)1.67222664
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66984696
131Polyuria (HP:0000103)1.66977733
132Abnormal drinking behavior (HP:0030082)1.66880075
133Polydipsia (HP:0001959)1.66880075
134Broad foot (HP:0001769)1.66835806
135Poor eye contact (HP:0000817)1.66200057
136Abnormality of the fovea (HP:0000493)1.65745658
137Dysmetria (HP:0001310)1.65614716
138Morphological abnormality of the pyramidal tract (HP:0002062)1.65164479
139Abnormal EKG (HP:0003115)1.64857943
140Anencephaly (HP:0002323)1.64672253
141Spastic tetraplegia (HP:0002510)1.64600908
142Amyotrophic lateral sclerosis (HP:0007354)1.63913565
143Bony spicule pigmentary retinopathy (HP:0007737)1.63406430
144Cerebellar dysplasia (HP:0007033)1.63073431
145Cupped ear (HP:0000378)1.62576358
146Unsteady gait (HP:0002317)1.61625235
147Preaxial hand polydactyly (HP:0001177)1.60780891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.86582447
2NTRK33.46183328
3MAP2K72.98763610
4TNIK2.89704702
5MAP3K42.30436437
6EPHA42.23717624
7MAP3K122.22888347
8MUSK2.05384934
9FRK2.01526057
10DYRK21.97002646
11MAPK131.92288256
12BMPR21.86452382
13MARK11.79276154
14NME11.77753950
15INSRR1.76652767
16MAP4K21.71485817
17PLK21.68891891
18AKT31.68363357
19MKNK21.67225720
20MINK11.55020767
21CSNK1G31.54760129
22PRPF4B1.47626286
23RIPK41.47014186
24NTRK21.46395265
25GRK71.41391938
26CSNK1A1L1.40032702
27CSNK1G11.36380268
28SGK21.33343789
29GRK51.32876982
30TRIM281.31870709
31CAMKK21.30156527
32SIK31.28999808
33MAP2K41.24058898
34ADRBK21.22875500
35OXSR11.22651765
36CDK81.18835862
37ARAF1.16202228
38SGK2231.13906604
39SGK4941.13906604
40NEK61.10075131
41PHKG21.09289009
42PHKG11.09289009
43CAMK2A1.08899568
44PRKCE1.08523814
45WNK31.06982482
46EPHB21.05948654
47STK38L1.03259728
48BMPR1B1.01694429
49PRKCG1.01421390
50DAPK21.00464906
51BRAF0.99328175
52PNCK0.97685411
53CDK190.94566198
54CDK30.94387393
55YES10.93133207
56MAP3K130.92871765
57FES0.89217430
58MAP3K90.88801609
59BCR0.86311761
60WNK10.85948020
61STK390.85792425
62GRK10.85653726
63PKN10.84680674
64CDK50.84373873
65SIK20.83224011
66PAK60.82256652
67PINK10.81802847
68NUAK10.78283746
69MKNK10.78167094
70STK380.77036770
71DYRK30.75904744
72DYRK1A0.75283929
73CAMK2B0.73856608
74CAMK2D0.73662625
75WNK40.73049261
76TNK20.71943164
77PRKCZ0.71330038
78CAMK10.70866364
79SGK10.65301318
80IRAK30.64108147
81KSR10.62668268
82ERBB40.62421342
83SRPK10.62155321
84ACVR1B0.61537547
85SGK30.60462106
86WEE10.59705535
87PRKACA0.57566217
88PIK3CA0.57390531
89TXK0.56991761
90DYRK1B0.55964273
91PLK40.54181946
92CAMK2G0.53059599
93OBSCN0.52751140
94CSNK1D0.52566289
95CSNK1E0.51537315
96BRD40.51277446
97CSNK1A10.51124884
98CDK140.50784290
99MAP3K60.50564226
100STK160.49909283
101FER0.49614939
102LIMK10.49608055
103CAMK40.49493320
104ADRBK10.48738723
105CAMKK10.48192214
106CDK180.47860367
107VRK10.47758358
108CDK150.46817584
109ERBB30.46746618
110IRAK10.46705452
111CCNB10.46454514
112MYLK0.46362146
113STK240.46066899
114DAPK10.45725923
115PRKAA10.44977911
116IRAK40.44970585
117MAP3K140.44748385
118IRAK20.43836404
119TAOK30.43301520
120PRKG10.43132759
121CDK11A0.42255940
122CDC42BPA0.41985137
123PAK30.41458536
124PRKD30.41316581
125UHMK10.40949822
126ZAK0.40447497
127STK110.40028215
128NEK10.39713067
129TYRO30.39651867
130PRKACB0.38509490
131CSNK1G20.36780140
132TAF10.35081905
133PRKCA0.34589571
134LMTK20.32916615

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.43526919
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15335794
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96719864
4GABAergic synapse_Homo sapiens_hsa047272.75671524
5Morphine addiction_Homo sapiens_hsa050322.71235942
6Olfactory transduction_Homo sapiens_hsa047402.68058713
7Taste transduction_Homo sapiens_hsa047422.60663013
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60124731
9Collecting duct acid secretion_Homo sapiens_hsa049662.52611592
10Oxidative phosphorylation_Homo sapiens_hsa001902.46285619
11Glutamatergic synapse_Homo sapiens_hsa047242.43170462
12Circadian entrainment_Homo sapiens_hsa047132.39489604
13Phototransduction_Homo sapiens_hsa047442.24187659
14Serotonergic synapse_Homo sapiens_hsa047262.12177370
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04195581
16Amphetamine addiction_Homo sapiens_hsa050311.90402484
17Long-term potentiation_Homo sapiens_hsa047201.86076871
18Insulin secretion_Homo sapiens_hsa049111.85863292
19Salivary secretion_Homo sapiens_hsa049701.81706348
20Dopaminergic synapse_Homo sapiens_hsa047281.75568541
21Parkinsons disease_Homo sapiens_hsa050121.73707215
22Propanoate metabolism_Homo sapiens_hsa006401.69756077
23Calcium signaling pathway_Homo sapiens_hsa040201.69063924
24Cardiac muscle contraction_Homo sapiens_hsa042601.68502601
25Alzheimers disease_Homo sapiens_hsa050101.68421803
26Cholinergic synapse_Homo sapiens_hsa047251.64711669
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62061773
28Long-term depression_Homo sapiens_hsa047301.60214071
29Renin secretion_Homo sapiens_hsa049241.51901786
30Protein export_Homo sapiens_hsa030601.49043432
31Vibrio cholerae infection_Homo sapiens_hsa051101.48729696
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46483562
33Huntingtons disease_Homo sapiens_hsa050161.35744133
34Oxytocin signaling pathway_Homo sapiens_hsa049211.35012854
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34680059
36Gastric acid secretion_Homo sapiens_hsa049711.33486056
37Cocaine addiction_Homo sapiens_hsa050301.21101045
38Nitrogen metabolism_Homo sapiens_hsa009101.20678979
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19021155
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16948493
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16774126
42cAMP signaling pathway_Homo sapiens_hsa040241.11914637
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08321070
44Rheumatoid arthritis_Homo sapiens_hsa053231.01073804
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00295670
46Type I diabetes mellitus_Homo sapiens_hsa049400.95222500
47GnRH signaling pathway_Homo sapiens_hsa049120.94763553
48Axon guidance_Homo sapiens_hsa043600.93786369
49Circadian rhythm_Homo sapiens_hsa047100.93049188
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90752842
51Dilated cardiomyopathy_Homo sapiens_hsa054140.90534204
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89282409
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88748260
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.87135336
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85767682
56Steroid biosynthesis_Homo sapiens_hsa001000.85237531
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84747812
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82286134
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81220386
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80942129
61Gap junction_Homo sapiens_hsa045400.80683640
62RNA degradation_Homo sapiens_hsa030180.79720546
63Fanconi anemia pathway_Homo sapiens_hsa034600.77767225
64Ovarian steroidogenesis_Homo sapiens_hsa049130.74835912
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74384020
66Melanogenesis_Homo sapiens_hsa049160.74283216
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73643339
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73397872
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67717150
70Hedgehog signaling pathway_Homo sapiens_hsa043400.65153023
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64640161
72Pancreatic secretion_Homo sapiens_hsa049720.64336053
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61549748
74Type II diabetes mellitus_Homo sapiens_hsa049300.61114224
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59724584
76Ether lipid metabolism_Homo sapiens_hsa005650.58301539
77RNA polymerase_Homo sapiens_hsa030200.57254110
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56861535
79Peroxisome_Homo sapiens_hsa041460.56019704
80* Ras signaling pathway_Homo sapiens_hsa040140.55577653
81beta-Alanine metabolism_Homo sapiens_hsa004100.55092470
82* MAPK signaling pathway_Homo sapiens_hsa040100.53824946
83Sphingolipid metabolism_Homo sapiens_hsa006000.53063612
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51370525
85Tryptophan metabolism_Homo sapiens_hsa003800.50918497
86Phagosome_Homo sapiens_hsa041450.50572826
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50048620
88Autoimmune thyroid disease_Homo sapiens_hsa053200.49486180
89ErbB signaling pathway_Homo sapiens_hsa040120.48730284
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48469112
91Inositol phosphate metabolism_Homo sapiens_hsa005620.46122944
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45903969
93* Melanoma_Homo sapiens_hsa052180.45224369
94Basal cell carcinoma_Homo sapiens_hsa052170.44937675
95Estrogen signaling pathway_Homo sapiens_hsa049150.44917230
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44437329
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41819857
98Caffeine metabolism_Homo sapiens_hsa002320.41025908
99Bile secretion_Homo sapiens_hsa049760.40861462
100Homologous recombination_Homo sapiens_hsa034400.40569656
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40383163
102Thyroid hormone synthesis_Homo sapiens_hsa049180.40003897
103Hippo signaling pathway_Homo sapiens_hsa043900.39684346
104Wnt signaling pathway_Homo sapiens_hsa043100.39627396
105African trypanosomiasis_Homo sapiens_hsa051430.39118023
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.38514973
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.35933039
108Arachidonic acid metabolism_Homo sapiens_hsa005900.34435811
109ABC transporters_Homo sapiens_hsa020100.34047229
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.33244090
111Glucagon signaling pathway_Homo sapiens_hsa049220.32955000
112Regulation of autophagy_Homo sapiens_hsa041400.32556362
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32433526
114Choline metabolism in cancer_Homo sapiens_hsa052310.32363374
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32305806
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30602339
117TGF-beta signaling pathway_Homo sapiens_hsa043500.30307374
118Metabolic pathways_Homo sapiens_hsa011000.30053563
119Dorso-ventral axis formation_Homo sapiens_hsa043200.29790135
120Purine metabolism_Homo sapiens_hsa002300.29781375
121Alcoholism_Homo sapiens_hsa050340.25607738
122Oocyte meiosis_Homo sapiens_hsa041140.25127294
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24671182
124* Rap1 signaling pathway_Homo sapiens_hsa040150.24498199
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22931939
126Mineral absorption_Homo sapiens_hsa049780.17332627
127Glioma_Homo sapiens_hsa052140.17095975
128Basal transcription factors_Homo sapiens_hsa030220.15773348
129Fatty acid elongation_Homo sapiens_hsa000620.15074954
130Linoleic acid metabolism_Homo sapiens_hsa005910.14971839
131Chemokine signaling pathway_Homo sapiens_hsa040620.14002740
132Butanoate metabolism_Homo sapiens_hsa006500.13957012

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