FGF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)7.40836601
2bone trabecula formation (GO:0060346)6.67778125
3* mesenchymal-epithelial cell signaling (GO:0060638)6.42740673
4craniofacial suture morphogenesis (GO:0097094)6.08364516
5regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.06403525
6chondrocyte proliferation (GO:0035988)5.99287937
7glomerular basement membrane development (GO:0032836)5.98981054
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.84202324
9collagen fibril organization (GO:0030199)5.84030827
10lateral sprouting from an epithelium (GO:0060601)5.80278396
11dermatan sulfate biosynthetic process (GO:0030208)5.27790639
12cellular response to vitamin D (GO:0071305)5.15083922
13cranial suture morphogenesis (GO:0060363)5.06114546
14keratan sulfate catabolic process (GO:0042340)4.92007518
15dermatan sulfate metabolic process (GO:0030205)4.84020452
16cell proliferation involved in metanephros development (GO:0072203)4.80350617
17* regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.79188871
18negative regulation of osteoblast proliferation (GO:0033689)4.77885235
19radial glial cell differentiation (GO:0060019)4.76740073
20branching involved in prostate gland morphogenesis (GO:0060442)4.70284349
21cell proliferation involved in kidney development (GO:0072111)4.60875914
22protein heterotrimerization (GO:0070208)4.59600321
23extracellular fibril organization (GO:0043206)4.56536303
24cellular response to vitamin (GO:0071295)4.47945009
25axon extension involved in axon guidance (GO:0048846)4.40077358
26neuron projection extension involved in neuron projection guidance (GO:1902284)4.40077358
27extracellular negative regulation of signal transduction (GO:1900116)4.37210324
28extracellular regulation of signal transduction (GO:1900115)4.37210324
29keratinocyte proliferation (GO:0043616)4.29674017
30branch elongation of an epithelium (GO:0060602)4.27824713
31planar cell polarity pathway involved in neural tube closure (GO:0090179)4.10238156
32blood vessel maturation (GO:0001955)4.06825225
33embryonic cranial skeleton morphogenesis (GO:0048701)4.01261413
34axis elongation (GO:0003401)3.95201401
35negative regulation of chondrocyte differentiation (GO:0032331)3.90975785
36regulation of osteoblast proliferation (GO:0033688)3.88724360
37fibril organization (GO:0097435)3.86064870
38metanephric mesenchyme development (GO:0072075)3.82443552
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.82171189
40extracellular matrix assembly (GO:0085029)3.72003438
41prostate gland epithelium morphogenesis (GO:0060740)3.71678843
42type B pancreatic cell proliferation (GO:0044342)3.69662416
43branching involved in labyrinthine layer morphogenesis (GO:0060670)3.66111374
44positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.65892533
45positive regulation of fibroblast migration (GO:0010763)3.64842001
46regulation of extracellular matrix disassembly (GO:0010715)3.63743251
47skin morphogenesis (GO:0043589)3.59739316
48negative regulation of fibroblast apoptotic process (GO:2000270)3.58166159
49negative regulation of stem cell proliferation (GO:2000647)3.56062772
50endodermal cell differentiation (GO:0035987)3.55408118
51kidney mesenchyme development (GO:0072074)3.53636277
52regulation of integrin-mediated signaling pathway (GO:2001044)3.52804217
53regulation of non-canonical Wnt signaling pathway (GO:2000050)3.52257517
54cartilage morphogenesis (GO:0060536)3.51201541
55outer ear morphogenesis (GO:0042473)3.49492825
56regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.44161325
57negative regulation of catenin import into nucleus (GO:0035414)3.40170870
58collagen metabolic process (GO:0032963)3.39565692
59glial cell migration (GO:0008347)3.39106570
60collagen catabolic process (GO:0030574)3.36510038
61negative regulation of leukocyte chemotaxis (GO:0002689)3.36398151
62smooth muscle tissue development (GO:0048745)3.34168485
63regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.33748281
64protein targeting to plasma membrane (GO:0072661)3.31990005
65positive regulation of extracellular matrix organization (GO:1903055)3.28320555
66limb bud formation (GO:0060174)3.28135524
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.24865967
68negative regulation of BMP signaling pathway (GO:0030514)3.24066767
69organ induction (GO:0001759)3.24035659
70positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.23973457
71chondrocyte development (GO:0002063)3.23478198
72cell migration involved in heart development (GO:0060973)3.21617776
73middle ear morphogenesis (GO:0042474)3.19080717
74otic vesicle formation (GO:0030916)3.17643403
75multicellular organismal macromolecule metabolic process (GO:0044259)3.13828755
76* protein localization to cell surface (GO:0034394)3.12694687
77platelet-derived growth factor receptor signaling pathway (GO:0048008)3.12625990
78peptidyl-proline hydroxylation (GO:0019511)3.12320562
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.12131021
80mesodermal cell differentiation (GO:0048333)3.12052861
81mesenchymal cell differentiation (GO:0048762)3.11543907
82wound healing, spreading of epidermal cells (GO:0035313)3.10643129
83substrate adhesion-dependent cell spreading (GO:0034446)3.09501085
84positive regulation of macrophage activation (GO:0043032)3.03876567
85response to follicle-stimulating hormone (GO:0032354)3.03104882
86multicellular organismal catabolic process (GO:0044243)3.02930405
87vascular endothelial growth factor signaling pathway (GO:0038084)3.02865066
88fibroblast migration (GO:0010761)3.02548654
89convergent extension (GO:0060026)3.02124140
90positive regulation of endothelial cell apoptotic process (GO:2000353)3.00920614
91regulation of tight junction assembly (GO:2000810)3.00060794
92response to redox state (GO:0051775)2.99784331
93mesonephros development (GO:0001823)2.99536315
94face morphogenesis (GO:0060325)2.98264137
95negative regulation of cartilage development (GO:0061037)2.97725429
96negative regulation of JUN kinase activity (GO:0043508)2.97279643
97negative regulation of fatty acid transport (GO:2000192)2.97092707
98multicellular organismal metabolic process (GO:0044236)2.95039773
99positive regulation of mesenchymal cell proliferation (GO:0002053)2.94860462
100ureteric bud development (GO:0001657)2.93923263
101mesonephric tubule development (GO:0072164)2.93741069
102regulation of mesenchymal cell proliferation (GO:0010464)2.92843251
103regulation of chondrocyte differentiation (GO:0032330)2.92442304
104negative chemotaxis (GO:0050919)2.92237712
105lung vasculature development (GO:0060426)2.92117609
106negative regulation of complement activation (GO:0045916)2.91900460
107pattern specification involved in kidney development (GO:0061004)2.91274462
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89152696
109extracellular matrix organization (GO:0030198)2.88484910
110negative regulation of embryonic development (GO:0045992)2.88219978
111epithelial to mesenchymal transition (GO:0001837)2.88031736
112extracellular structure organization (GO:0043062)2.87480563
113mesonephric epithelium development (GO:0072163)2.85899456
114positive regulation of protein autophosphorylation (GO:0031954)2.82036617
115regulation of cartilage development (GO:0061035)2.81569638
116chondroitin sulfate catabolic process (GO:0030207)2.79541198
117wound healing, spreading of cells (GO:0044319)2.79089407
118induction of positive chemotaxis (GO:0050930)2.78812466
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78575852
120negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.77745969
121extracellular matrix disassembly (GO:0022617)2.76681382
122cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.75502114
123trabecula formation (GO:0060343)2.75141969
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.74886322
125regulation of organ formation (GO:0003156)2.74786600
126endocrine hormone secretion (GO:0060986)2.74150818
127protein hydroxylation (GO:0018126)2.73371469
128protein retention in ER lumen (GO:0006621)2.73189399
129regulation of type B pancreatic cell apoptotic process (GO:2000674)2.64405434
130adhesion of symbiont to host cell (GO:0044650)2.63010302
131virion attachment to host cell (GO:0019062)2.63010302
132pericardium development (GO:0060039)2.59372762
133muscle cell fate commitment (GO:0042693)2.59310171
134peptide cross-linking (GO:0018149)2.57793239
135tooth mineralization (GO:0034505)2.57367253
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55694615
137peripheral nervous system axon ensheathment (GO:0032292)2.54695697
138myelination in peripheral nervous system (GO:0022011)2.54695697
139negative regulation of protein activation cascade (GO:2000258)2.50412472
140regulation of fibroblast migration (GO:0010762)2.50101616
141cellular response to amino acid stimulus (GO:0071230)2.45633531
142regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.45136454
143toxin metabolic process (GO:0009404)2.43828633
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43240854
145negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.42830300
146lung secretory cell differentiation (GO:0061140)2.42543588
147blood vessel remodeling (GO:0001974)2.41361452
148adrenal gland development (GO:0030325)2.40917447
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.40680815
150regulation of cardiac muscle hypertrophy (GO:0010611)2.40243768
151white fat cell differentiation (GO:0050872)2.37622270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.34197034
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.97348046
3CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.28581915
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97303633
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.89723618
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89035192
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.82638798
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.81752069
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75897402
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.72654914
11* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65542575
12* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.52716132
13* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.52716132
14CJUN_26792858_Chip-Seq_BT549_Human2.42173317
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.30313234
16TP53_18474530_ChIP-ChIP_U2OS_Human2.17757314
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17114089
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15698630
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13484821
20BRD4_25478319_ChIP-Seq_HGPS_Human2.11407253
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.09897368
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09784171
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05136868
24TP53_16413492_ChIP-PET_HCT116_Human2.03609155
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00202499
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98774629
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98774629
28* GBX2_23144817_ChIP-Seq_PC3_Human1.97175629
29* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96140299
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95748696
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95549316
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91200885
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.89976256
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84826733
35AR_21572438_ChIP-Seq_LNCaP_Human1.81808776
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73792287
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73613372
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.73340077
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72155666
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.63152686
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62706972
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61951974
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60786707
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58971574
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.58588979
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58194396
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.55588147
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51399788
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.51016831
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44982748
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41174144
52CLOCK_20551151_ChIP-Seq_293T_Human1.40593431
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39951630
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36749479
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36582852
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.35462068
57RXR_22108803_ChIP-Seq_LS180_Human1.34514718
58SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33795069
59P300_19829295_ChIP-Seq_ESCs_Human1.30532423
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29616854
61* SA1_22415368_ChIP-Seq_MEFs_Mouse1.28563578
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.28465838
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25772002
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.25449855
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24465096
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.23950286
67FUS_26573619_Chip-Seq_HEK293_Human1.23343606
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22496280
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22496280
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22496280
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.22251292
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20474754
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19294734
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19294734
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.19243462
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18687061
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18119322
78* ER_23166858_ChIP-Seq_MCF-7_Human1.16821841
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15509276
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14977891
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13993126
82* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12761349
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12732588
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12651987
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11933121
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11492891
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10580449
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10306567
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09974421
90* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09539274
91BCAT_22108803_ChIP-Seq_LS180_Human1.09418096
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.09258418
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09129333
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08602841
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08371309
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07600498
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.07600415
98SOX2_20726797_ChIP-Seq_SW620_Human1.07576466
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07246754
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.06859166
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06663499
102STAT3_23295773_ChIP-Seq_U87_Human1.06239647
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05328060
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04925883
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.03770212
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.02423275
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02364502
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01326461
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00984359
110EWS_26573619_Chip-Seq_HEK293_Human1.00765618
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.00729657
112* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00688086
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00547420
114* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00490387
115* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00316448
116JUN_21703547_ChIP-Seq_K562_Human0.98228667
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98055151
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96169206
119TP63_23658742_ChIP-Seq_EP156T_Human0.95558872
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95266920
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95168770
122* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94806855
123* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93315070
124AR_25329375_ChIP-Seq_VCAP_Human0.92993851
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92898979
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.92634411
127CRX_20693478_ChIP-Seq_RETINA_Mouse0.92243183
128KDM2B_26808549_Chip-Seq_REH_Human0.91803208
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.91099595
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90827294
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89247615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.64519239
2MP0005503_abnormal_tendon_morphology6.07540849
3MP0005275_abnormal_skin_tensile4.60521942
4MP0001958_emphysema3.42508373
5MP0003279_aneurysm3.38676342
6MP0003705_abnormal_hypodermis_morpholog3.35847400
7MP0009384_cardiac_valve_regurgitation3.00927927
8MP0005257_abnormal_intraocular_pressure2.95757136
9MP0001299_abnormal_eye_distance/2.71376551
10MP0009250_abnormal_appendicular_skeleto2.65667374
11MP0004272_abnormal_basement_membrane2.64020284
12MP0005508_abnormal_skeleton_morphology2.35237574
13MP0009780_abnormal_chondrocyte_physiolo2.31840619
14MP0002295_abnormal_pulmonary_circulatio2.26197052
15MP0002938_white_spotting2.24941626
16MP0010030_abnormal_orbit_morphology2.23990743
17MP0003950_abnormal_plasma_membrane2.19607705
18MP0002108_abnormal_muscle_morphology2.05602751
19MP0000428_abnormal_craniofacial_morphol1.96859492
20MP0003385_abnormal_body_wall1.82272616
21MP0002282_abnormal_trachea_morphology1.80625593
22MP0005623_abnormal_meninges_morphology1.72630396
23MP0002896_abnormal_bone_mineralization1.71935944
24MP0004134_abnormal_chest_morphology1.69965208
25MP0001542_abnormal_bone_strength1.67627952
26MP0005023_abnormal_wound_healing1.60703846
27MP0010386_abnormal_urinary_bladder1.57225924
28MP0003091_abnormal_cell_migration1.54867183
29MP0001243_abnormal_dermal_layer1.52548701
30MP0002060_abnormal_skin_morphology1.49753129
31MP0002115_abnormal_skeleton_extremities1.44836473
32MP0003937_abnormal_limbs/digits/tail_de1.44789574
33MP0000163_abnormal_cartilage_morphology1.44131838
34MP0006054_spinal_hemorrhage1.43637463
35MP0005187_abnormal_penis_morphology1.42108582
36MP0003755_abnormal_palate_morphology1.40995760
37MP0002102_abnormal_ear_morphology1.38205420
38MP0005171_absent_coat_pigmentation1.36613645
39MP0010368_abnormal_lymphatic_system1.36198927
40MP0000566_synostosis1.35613496
41MP0005595_abnormal_vascular_smooth1.32726088
42MP0005390_skeleton_phenotype1.28381256
43MP0001177_atelectasis1.27570858
44MP0002177_abnormal_outer_ear1.25216342
45MP0002168_other_aberrant_phenotype1.24989460
46* MP0003942_abnormal_urinary_system1.23667450
47MP0000049_abnormal_middle_ear1.21284028
48MP0005248_abnormal_Harderian_gland1.18841332
49MP0005377_hearing/vestibular/ear_phenot1.18252283
50MP0003878_abnormal_ear_physiology1.18252283
51MP0000767_abnormal_smooth_muscle1.17691784
52MP0002932_abnormal_joint_morphology1.16002653
53MP0002116_abnormal_craniofacial_bone1.15043114
54MP0004084_abnormal_cardiac_muscle1.14648187
55MP0000516_abnormal_urinary_system1.13979429
56MP0005367_renal/urinary_system_phenotyp1.13979429
57MP0002113_abnormal_skeleton_development1.13847582
58MP0002109_abnormal_limb_morphology1.13721781
59MP0002998_abnormal_bone_remodeling1.11092121
60MP0002933_joint_inflammation1.10675778
61MP0000432_abnormal_head_morphology1.09802259
62MP0000733_abnormal_muscle_development1.08852952
63MP0001661_extended_life_span1.08712554
64MP0000534_abnormal_ureter_morphology1.07659600
65MP0000762_abnormal_tongue_morphology1.06917791
66MP0001346_abnormal_lacrimal_gland1.06243115
67MP0010352_gastrointestinal_tract_polyps1.05764883
68MP0009053_abnormal_anal_canal1.04903163
69MP0003941_abnormal_skin_development1.04834743
70MP0003935_abnormal_craniofacial_develop1.02574899
71MP0001293_anophthalmia0.97979327
72MP0002133_abnormal_respiratory_system0.97249888
73MP0005388_respiratory_system_phenotype0.97249888
74MP0001756_abnormal_urination0.96931846
75MP0003566_abnormal_cell_adhesion0.96700914
76MP0000003_abnormal_adipose_tissue0.92473054
77MP0000537_abnormal_urethra_morphology0.91332638
78MP0001348_abnormal_lacrimal_gland0.88576458
79MP0000750_abnormal_muscle_regeneration0.88388553
80MP0008004_abnormal_stomach_pH0.88296510
81MP0003795_abnormal_bone_structure0.84090533
82MP0000427_abnormal_hair_cycle0.82866904
83MP0005076_abnormal_cell_differentiation0.82566091
84MP0000749_muscle_degeneration0.82438557
85MP0003115_abnormal_respiratory_system0.81282281
86MP0002233_abnormal_nose_morphology0.80497280
87MP0001175_abnormal_lung_morphology0.79588814
88MP0005220_abnormal_exocrine_pancreas0.79252092
89MP0002089_abnormal_postnatal_growth/wei0.79074980
90MP0004036_abnormal_muscle_relaxation0.78238879
91MP0003045_fibrosis0.77179282
92MP0000372_irregular_coat_pigmentation0.77027483
93MP0002249_abnormal_larynx_morphology0.76728177
94MP0000647_abnormal_sebaceous_gland0.76182224
95MP0000751_myopathy0.75488163
96MP0004885_abnormal_endolymph0.73995859
97MP0002114_abnormal_axial_skeleton0.73390751
98MP0000759_abnormal_skeletal_muscle0.72044312
99MP0004883_abnormal_blood_vessel0.71301993
100MP0005164_abnormal_response_to0.71044760
101MP0001340_abnormal_eyelid_morphology0.70774087
102MP0000230_abnormal_systemic_arterial0.70632603
103MP0010307_abnormal_tumor_latency0.69960003
104MP0003938_abnormal_ear_development0.69479427
105MP0005369_muscle_phenotype0.69095312
106MP0000538_abnormal_urinary_bladder0.68111671
107MP0000013_abnormal_adipose_tissue0.67790758
108MP0000681_abnormal_thyroid_gland0.66934269
109MP0005193_abnormal_anterior_eye0.66208432
110MP0000579_abnormal_nail_morphology0.65442666
111MP0008775_abnormal_heart_ventricle0.65069770
112MP0002128_abnormal_blood_circulation0.64959691
113MP0001533_abnormal_skeleton_physiology0.64742966
114MP0002111_abnormal_tail_morphology0.64646909
115MP0001879_abnormal_lymphatic_vessel0.64321736
116MP0006072_abnormal_retinal_apoptosis0.63896597
117MP0002876_abnormal_thyroid_physiology0.63546158
118MP0002092_abnormal_eye_morphology0.63196969
119MP0000462_abnormal_digestive_system0.61558753
120MP0004233_abnormal_muscle_weight0.56976210
121MP0005165_increased_susceptibility_to0.55340660
122MP0001614_abnormal_blood_vessel0.54646829
123MP0002132_abnormal_respiratory_system0.54440209
124MP0003448_altered_tumor_morphology0.53626742
125MP0005620_abnormal_muscle_contractility0.51165935
126MP0000613_abnormal_salivary_gland0.49612608
127MP0000343_altered_response_to0.48928449
128MP0002160_abnormal_reproductive_system0.47292166

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.46846088
2Premature rupture of membranes (HP:0001788)6.65466727
3Shallow orbits (HP:0000586)4.99805184
4Abnormality of the parietal bone (HP:0002696)4.51110910
5Broad metatarsal (HP:0001783)4.49301146
6Peritonitis (HP:0002586)4.43659731
7Soft skin (HP:0000977)4.17775388
8Aortic dissection (HP:0002647)4.07492882
9Aortic aneurysm (HP:0004942)4.05776584
10Short 4th metacarpal (HP:0010044)3.61131799
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.61131799
12Ankle contracture (HP:0006466)3.54691686
13Infantile muscular hypotonia (HP:0008947)3.49038000
14Cervical subluxation (HP:0003308)3.41845831
15Absent frontal sinuses (HP:0002688)3.41538946
16Bell-shaped thorax (HP:0001591)3.40969843
17Aplasia involving bones of the extremities (HP:0009825)3.36891291
18Aplasia involving bones of the upper limbs (HP:0009823)3.36891291
19Aplasia of the phalanges of the hand (HP:0009802)3.36891291
20Bladder diverticulum (HP:0000015)3.32807405
21Vertebral compression fractures (HP:0002953)3.31311291
22Coronal craniosynostosis (HP:0004440)3.28799721
23Midline defect of the nose (HP:0004122)3.28730784
24Osteolytic defects of the hand bones (HP:0009699)3.25524953
25Osteolytic defects of the phalanges of the hand (HP:0009771)3.25524953
26Wormian bones (HP:0002645)3.17989163
27Biconcave vertebral bodies (HP:0004586)3.17708219
28Microglossia (HP:0000171)3.17589358
29Abnormality of dentin (HP:0010299)3.17273661
30Wrist flexion contracture (HP:0001239)3.16598917
31Dilatation of the ascending aorta (HP:0005111)3.15629484
32Atrophic scars (HP:0001075)3.13226441
33Vascular tortuosity (HP:0004948)3.07074624
34Broad face (HP:0000283)3.04538836
35Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.99931252
36Follicular hyperkeratosis (HP:0007502)2.94866574
37Keratoconus (HP:0000563)2.91904343
38Increased corneal curvature (HP:0100692)2.91904343
39Trigonocephaly (HP:0000243)2.91747954
40Delayed closure of the anterior fontanelle (HP:0001476)2.86080848
41Hypoplasia of the iris (HP:0007676)2.84970075
42Neonatal short-limb short stature (HP:0008921)2.77738240
43Aortic regurgitation (HP:0001659)2.75929990
44Nasolacrimal duct obstruction (HP:0000579)2.74873436
45Fragile skin (HP:0001030)2.74444773
46Blue sclerae (HP:0000592)2.72553287
47Mesomelia (HP:0003027)2.71720852
48Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.70757016
49Abnormality of the frontal sinuses (HP:0002687)2.70500622
50Genu recurvatum (HP:0002816)2.69757430
51Persistence of primary teeth (HP:0006335)2.69011842
52Cerebral aneurysm (HP:0004944)2.66303371
53Hyperextensible skin (HP:0000974)2.66009343
54Sparse lateral eyebrow (HP:0005338)2.60719206
55Abnormality of the 4th metacarpal (HP:0010012)2.60210950
56Overgrowth (HP:0001548)2.59079646
57Toxemia of pregnancy (HP:0100603)2.57799248
58Decreased skull ossification (HP:0004331)2.55866061
59Increased variability in muscle fiber diameter (HP:0003557)2.52095642
60Striae distensae (HP:0001065)2.51973961
61Abnormality of the nasal septum (HP:0000419)2.50997162
62Abnormality of the distal phalanx of the thumb (HP:0009617)2.44890227
63Bowel diverticulosis (HP:0005222)2.40892250
64Alacrima (HP:0000522)2.39685809
65Aneurysm (HP:0002617)2.39352473
66Mitral stenosis (HP:0001718)2.38697582
67Joint laxity (HP:0001388)2.37852503
68Corneal dystrophy (HP:0001131)2.37301803
69Wide anterior fontanel (HP:0000260)2.35005560
70Exostoses (HP:0100777)2.34185881
71Spinal rigidity (HP:0003306)2.31575589
72Spinal cord lesions (HP:0100561)2.30638591
73Syringomyelia (HP:0003396)2.30638591
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.29442945
75Metaphyseal dysplasia (HP:0100255)2.27921507
76Flared iliac wings (HP:0002869)2.27604653
77Type 1 muscle fiber predominance (HP:0003803)2.27251478
78Arterial tortuosity (HP:0005116)2.27162299
79Abnormality of skull ossification (HP:0002703)2.26607859
80Aortic valve stenosis (HP:0001650)2.25165462
81Abnormality of the peritoneum (HP:0002585)2.23312540
82Cardiovascular calcification (HP:0011915)2.22592416
83Congenital glaucoma (HP:0001087)2.21467966
84Joint stiffness (HP:0001387)2.20616685
85Ovoid vertebral bodies (HP:0003300)2.19939875
86Mild short stature (HP:0003502)2.16430737
87Abnormality of the acetabulum (HP:0003170)2.15158201
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.14537447
89Round ear (HP:0100830)2.14491399
90Abnormal delivery (HP:0001787)2.14200782
91Abnormality of incisor morphology (HP:0011063)2.13873026
92Buphthalmos (HP:0000557)2.11477099
93Partial duplication of the phalanx of hand (HP:0009999)2.10831995
94Deviation of the hallux (HP:0010051)2.10649837
95Recurrent corneal erosions (HP:0000495)2.09450956
96Abnormality of the nasolacrimal system (HP:0000614)2.08960276
97Ulnar bowing (HP:0003031)2.08214580
98Increased density of long bones (HP:0006392)2.07398290
99Mitral valve prolapse (HP:0001634)2.07284266
100Mildly elevated creatine phosphokinase (HP:0008180)2.05837895
101Broad hallux (HP:0010055)2.05697749
102Ectopia lentis (HP:0001083)2.05295118
103Slender build (HP:0001533)2.04819126
104Pulmonary artery stenosis (HP:0004415)2.02490008
105Concave nail (HP:0001598)2.00833437
106Flat capital femoral epiphysis (HP:0003370)1.98481922
107Broad toe (HP:0001837)1.96991529
108Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.96592913
109Turricephaly (HP:0000262)1.96556618
110Premature skin wrinkling (HP:0100678)1.96128310
111Abnormality of the lacrimal duct (HP:0011481)1.95332249
112Delayed cranial suture closure (HP:0000270)1.94248067
113Hypoplastic ischia (HP:0003175)1.92558598
114Hallux valgus (HP:0001822)1.92470588
115Broad ribs (HP:0000885)1.92152398
116Abnormality of the middle phalanges of the hand (HP:0009833)1.92098604
117Abnormality of skeletal muscle fiber size (HP:0012084)1.91530593
118Elbow flexion contracture (HP:0002987)1.91506364
119Broad long bones (HP:0005622)1.89991823
120White forelock (HP:0002211)1.89766257
121Spondylolisthesis (HP:0003302)1.89403575
122Narrow palate (HP:0000189)1.89189139
123Osteoarthritis (HP:0002758)1.86630986
124Humeroradial synostosis (HP:0003041)1.86455596
125Synostosis involving the elbow (HP:0003938)1.86455596
126Decreased lacrimation (HP:0000633)1.86208153
127Hypoventilation (HP:0002791)1.86124483
128Neoplasm of the heart (HP:0100544)1.85741628
129Anteriorly placed anus (HP:0001545)1.85602822
130Abnormality of the diencephalon (HP:0010662)1.84999444
131Protruding ear (HP:0000411)1.84895268
132Asymmetry of the thorax (HP:0001555)1.83572791
133Increased number of teeth (HP:0011069)1.83157552
134Camptodactyly of toe (HP:0001836)1.82767152
135Abnormality of primary teeth (HP:0006481)1.82175932
136Tibial bowing (HP:0002982)1.81964235
137Delayed gross motor development (HP:0002194)1.80991836
138Femoral bowing (HP:0002980)1.80735819
139Mitral regurgitation (HP:0001653)1.79924289
140Glomerulonephritis (HP:0000099)1.79660738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.59912675
2LATS14.16620476
3FGFR23.83364444
4PDGFRA3.78091250
5LATS23.40806294
6TTN2.92310402
7EPHA32.69012421
8PIK3CA2.65455688
9FER2.44918348
10SIK12.40526897
11GRK12.25307556
12GRK52.19347596
13PAK22.10393274
14ADRBK22.00533720
15FGFR11.98800446
16BMX1.90757972
17NUAK11.87845094
18GRK71.86444520
19FRK1.81370701
20STK31.80983500
21TRPM71.78700511
22PDGFRB1.60619668
23EPHB21.57477283
24PINK11.55311892
25DMPK1.55098225
26LIMK11.52087585
27NEK91.51166846
28MOS1.50712696
29PAK31.46709610
30CASK1.43205499
31KIT1.39720516
32PLK21.37822073
33MAP3K121.36494265
34STK381.32131059
35ROCK11.29122688
36PTK2B1.25005981
37INSRR1.19280391
38MAPKAPK51.16117374
39TYK21.14915277
40WNK11.14567127
41TRIB31.12817728
42RPS6KA41.10162037
43STK241.09695638
44PTK21.05975527
45ERBB31.04023205
46PRKD20.99512909
47MUSK0.95897894
48MAPK70.93861702
49ZAK0.92671665
50MET0.91664685
51TESK10.91602062
52EIF2AK20.91535435
53MKNK10.91035565
54PIK3CG0.90330953
55ERN10.88801745
56GSK3A0.87532483
57ILK0.81861716
58MAP3K60.78358060
59ROCK20.77919173
60NLK0.76089368
61PAK60.75717219
62JAK10.74978505
63INSR0.73781744
64MAPKAPK30.70910100
65PRPF4B0.69025327
66CAMK2B0.68737356
67NME20.67788118
68PRKD10.67017836
69STK38L0.66395612
70TGFBR20.65652787
71OBSCN0.65523570
72PRKCE0.65279217
73TIE10.63592239
74PIM20.63520338
75DAPK30.62586489
76SGK20.61957622
77RIPK10.59284441
78ADRBK10.57825765
79CDC42BPA0.57057719
80BMPR1B0.56351991
81MTOR0.56260754
82PRKCH0.54988243
83TESK20.53642372
84EPHB10.53295595
85CAMKK20.52157929
86MKNK20.51689695
87SGK30.50569911
88FGFR40.49914771
89MYLK0.49770866
90TNIK0.49714795
91PLK30.49354838
92IRAK10.47758526
93ABL20.47181952
94GRK60.45261949
95CAMK2G0.44926027
96MAP3K20.44055653
97SGK4940.43397823
98SGK2230.43397823
99CAMK1D0.43259097
100PRKG20.43210791
101CDK80.42584846
102PKN20.42473798
103MAPK40.41965409
104MELK0.41685289
105TGFBR10.40437967
106CHEK20.40102326
107LRRK20.39449898
108MAP3K30.39102517
109IGF1R0.38652726
110CAMK2D0.37581218
111MARK20.37289785
112TNK20.37141582
113PAK10.36828349
114MAPK10.36724583
115ERBB40.36702330
116NTRK10.36575663
117MAP4K20.36206980
118NEK60.35333241
119CDK60.35252967
120SRC0.34196501
121TLK10.33262377
122MARK10.33191488
123RET0.32068852
124MAP2K10.31263381
125HIPK20.31134322
126CAMK2A0.30853506
127CDK140.30237849
128PRKD30.30070889
129RPS6KA20.29466083
130ACVR1B0.29177477
131ABL10.28632385
132PAK40.28524643
133AKT30.27222499
134PRKG10.26995739
135CDK90.26542848
136FLT30.26114423
137PBK0.25786580
138FGFR30.25341435
139TAOK20.24342876
140CSNK1A10.22458272
141MAP3K70.22316497

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.18837265
2Basal cell carcinoma_Homo sapiens_hsa052173.12100799
3Hedgehog signaling pathway_Homo sapiens_hsa043402.98402768
4Focal adhesion_Homo sapiens_hsa045102.94171678
5TGF-beta signaling pathway_Homo sapiens_hsa043502.81454370
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.67338377
7Malaria_Homo sapiens_hsa051442.62495760
8Proteoglycans in cancer_Homo sapiens_hsa052052.36469186
9* Melanoma_Homo sapiens_hsa052182.11332735
10Adherens junction_Homo sapiens_hsa045202.09789478
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07226036
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.97505013
13MicroRNAs in cancer_Homo sapiens_hsa052061.96928264
14Wnt signaling pathway_Homo sapiens_hsa043101.95183054
15Protein digestion and absorption_Homo sapiens_hsa049741.94956181
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94067168
17Hippo signaling pathway_Homo sapiens_hsa043901.90256872
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.86502969
19Complement and coagulation cascades_Homo sapiens_hsa046101.83564679
20Dilated cardiomyopathy_Homo sapiens_hsa054141.83230852
21* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.82930645
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.82039323
23Amoebiasis_Homo sapiens_hsa051461.81372622
24Circadian rhythm_Homo sapiens_hsa047101.78582518
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70061336
26Prostate cancer_Homo sapiens_hsa052151.63691571
27Mineral absorption_Homo sapiens_hsa049781.55098239
28Small cell lung cancer_Homo sapiens_hsa052221.53139227
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51497182
30* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.48587781
31Bladder cancer_Homo sapiens_hsa052191.47594971
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46381561
33Axon guidance_Homo sapiens_hsa043601.45095958
34* Pathways in cancer_Homo sapiens_hsa052001.43577028
35Nitrogen metabolism_Homo sapiens_hsa009101.34514985
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30170505
37Chronic myeloid leukemia_Homo sapiens_hsa052201.22532530
38* Rap1 signaling pathway_Homo sapiens_hsa040151.14520321
39Renin secretion_Homo sapiens_hsa049241.12380363
40Glioma_Homo sapiens_hsa052141.12105793
41Calcium signaling pathway_Homo sapiens_hsa040201.10183805
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09580637
43Phagosome_Homo sapiens_hsa041451.08573801
44TNF signaling pathway_Homo sapiens_hsa046681.06262481
45p53 signaling pathway_Homo sapiens_hsa041151.04913881
46ABC transporters_Homo sapiens_hsa020101.04570316
47* Ras signaling pathway_Homo sapiens_hsa040141.03495425
48Ovarian steroidogenesis_Homo sapiens_hsa049131.03429365
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.99449833
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97513716
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93619273
52Viral myocarditis_Homo sapiens_hsa054160.93388019
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93228739
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.92700222
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91052422
56ErbB signaling pathway_Homo sapiens_hsa040120.90118904
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89989188
58Colorectal cancer_Homo sapiens_hsa052100.88141503
59Dorso-ventral axis formation_Homo sapiens_hsa043200.87975233
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86356268
61Shigellosis_Homo sapiens_hsa051310.85998830
62Pertussis_Homo sapiens_hsa051330.85736853
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84771167
64Pancreatic cancer_Homo sapiens_hsa052120.84317028
65Platelet activation_Homo sapiens_hsa046110.84105741
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.80013937
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79148936
68Tight junction_Homo sapiens_hsa045300.77939242
69HTLV-I infection_Homo sapiens_hsa051660.76695392
70Renal cell carcinoma_Homo sapiens_hsa052110.74606124
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74293205
72Rheumatoid arthritis_Homo sapiens_hsa053230.73977535
73Chemical carcinogenesis_Homo sapiens_hsa052040.73412783
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72514313
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72182792
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.71495913
77Gap junction_Homo sapiens_hsa045400.70569159
78Protein export_Homo sapiens_hsa030600.67308087
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66128141
80Lysosome_Homo sapiens_hsa041420.64630251
81Insulin secretion_Homo sapiens_hsa049110.63651105
82* MAPK signaling pathway_Homo sapiens_hsa040100.62812511
83Toxoplasmosis_Homo sapiens_hsa051450.62791883
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62561709
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62554261
86Tryptophan metabolism_Homo sapiens_hsa003800.61821705
87Circadian entrainment_Homo sapiens_hsa047130.61549063
88Hepatitis B_Homo sapiens_hsa051610.61420258
89Renin-angiotensin system_Homo sapiens_hsa046140.60866850
90Glutathione metabolism_Homo sapiens_hsa004800.60740060
91Steroid biosynthesis_Homo sapiens_hsa001000.60694266
92cAMP signaling pathway_Homo sapiens_hsa040240.60214974
93Sulfur metabolism_Homo sapiens_hsa009200.58691517
94Melanogenesis_Homo sapiens_hsa049160.58648363
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.58557182
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57483162
97HIF-1 signaling pathway_Homo sapiens_hsa040660.56885138
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55906034
99Glutamatergic synapse_Homo sapiens_hsa047240.54525581
100Viral carcinogenesis_Homo sapiens_hsa052030.54332012
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53982164
102GABAergic synapse_Homo sapiens_hsa047270.52690527
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52154466
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.51525493
105Endocytosis_Homo sapiens_hsa041440.51225172
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50191705
107Fatty acid degradation_Homo sapiens_hsa000710.48900580
108Long-term depression_Homo sapiens_hsa047300.48655637
109Gastric acid secretion_Homo sapiens_hsa049710.48595808
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47633110
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47258245
112Cocaine addiction_Homo sapiens_hsa050300.46472584
113Salivary secretion_Homo sapiens_hsa049700.46391280
114Vitamin B6 metabolism_Homo sapiens_hsa007500.45804609
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.45712492
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44194804
117Thyroid hormone synthesis_Homo sapiens_hsa049180.44099551
118Sphingolipid metabolism_Homo sapiens_hsa006000.43900324
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43616584
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42730970
121Insulin resistance_Homo sapiens_hsa049310.41822364
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41525857
123Cell cycle_Homo sapiens_hsa041100.40808275
124FoxO signaling pathway_Homo sapiens_hsa040680.40268294
125Cholinergic synapse_Homo sapiens_hsa047250.39516539
126Salmonella infection_Homo sapiens_hsa051320.38185556
127Estrogen signaling pathway_Homo sapiens_hsa049150.35500715
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35378566
129GnRH signaling pathway_Homo sapiens_hsa049120.33634933
130Endometrial cancer_Homo sapiens_hsa052130.33568520
131Choline metabolism in cancer_Homo sapiens_hsa052310.33037610
132Arachidonic acid metabolism_Homo sapiens_hsa005900.29881468
133One carbon pool by folate_Homo sapiens_hsa006700.29144181
134Vibrio cholerae infection_Homo sapiens_hsa051100.29097567
135N-Glycan biosynthesis_Homo sapiens_hsa005100.28384263
136Oxytocin signaling pathway_Homo sapiens_hsa049210.28134017
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.27926199
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.27768569
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27218299
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26292559
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.25405006
142AMPK signaling pathway_Homo sapiens_hsa041520.23821845
143mTOR signaling pathway_Homo sapiens_hsa041500.22946974

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