FGF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.13384862
2maturation of SSU-rRNA (GO:0030490)5.11898902
3protein localization to kinetochore (GO:0034501)5.00994505
4ribosomal small subunit assembly (GO:0000028)4.99095968
5DNA replication initiation (GO:0006270)4.92547576
6DNA strand elongation involved in DNA replication (GO:0006271)4.79117308
7nucleobase biosynthetic process (GO:0046112)4.72696545
8formation of translation preinitiation complex (GO:0001731)4.64852834
9purine nucleobase biosynthetic process (GO:0009113)4.55515668
10DNA strand elongation (GO:0022616)4.55390476
11DNA deamination (GO:0045006)4.44372621
12ribosomal small subunit biogenesis (GO:0042274)4.43290858
13viral transcription (GO:0019083)4.34832052
14translational termination (GO:0006415)4.27403447
15ribosome assembly (GO:0042255)4.20283687
16ribosome biogenesis (GO:0042254)4.15975546
17mitotic metaphase plate congression (GO:0007080)4.12593974
18ribonucleoprotein complex biogenesis (GO:0022613)4.12084961
19protein localization to chromosome, centromeric region (GO:0071459)4.10513915
20mitotic nuclear envelope disassembly (GO:0007077)4.09699043
21DNA replication checkpoint (GO:0000076)4.08440033
22telomere maintenance via semi-conservative replication (GO:0032201)4.05394954
23translational initiation (GO:0006413)3.89556902
24translational elongation (GO:0006414)3.88778374
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88677465
26folic acid-containing compound biosynthetic process (GO:0009396)3.83082472
27IMP biosynthetic process (GO:0006188)3.81407486
28ribosomal large subunit biogenesis (GO:0042273)3.79977761
29nuclear envelope disassembly (GO:0051081)3.79183119
30membrane disassembly (GO:0030397)3.79183119
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76616930
32CENP-A containing nucleosome assembly (GO:0034080)3.74001791
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.67222038
34spliceosomal snRNP assembly (GO:0000387)3.63721699
35viral mRNA export from host cell nucleus (GO:0046784)3.59469043
36chromatin remodeling at centromere (GO:0031055)3.57018602
37regulation of spindle organization (GO:0090224)3.55869061
38rRNA processing (GO:0006364)3.54603381
39metaphase plate congression (GO:0051310)3.54415638
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53066811
41DNA replication-independent nucleosome assembly (GO:0006336)3.50914313
42DNA replication-independent nucleosome organization (GO:0034724)3.50914313
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49178339
44telomere maintenance via recombination (GO:0000722)3.47000601
45cotranslational protein targeting to membrane (GO:0006613)3.44997072
46DNA replication-dependent nucleosome assembly (GO:0006335)3.44378405
47DNA replication-dependent nucleosome organization (GO:0034723)3.44378405
48protein targeting to ER (GO:0045047)3.43191516
49rRNA metabolic process (GO:0016072)3.42482872
50kinetochore organization (GO:0051383)3.42350074
51mitotic sister chromatid segregation (GO:0000070)3.41007345
52cellular protein complex disassembly (GO:0043624)3.40563853
53IMP metabolic process (GO:0046040)3.36807235
54mitotic recombination (GO:0006312)3.36018579
55negative regulation of RNA splicing (GO:0033119)3.30824249
56viral life cycle (GO:0019058)3.27902066
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25955209
58protein localization to endoplasmic reticulum (GO:0070972)3.24079552
59folic acid metabolic process (GO:0046655)3.21451380
60kinetochore assembly (GO:0051382)3.20497951
61protein complex disassembly (GO:0043241)3.19513448
62telomere maintenance via telomere lengthening (GO:0010833)3.18842478
63nuclear pore organization (GO:0006999)3.18625281
64DNA topological change (GO:0006265)3.15924166
65histone exchange (GO:0043486)3.12285274
66proteasome assembly (GO:0043248)3.11548048
67DNA duplex unwinding (GO:0032508)3.08956681
68pseudouridine synthesis (GO:0001522)3.07358508
69DNA geometric change (GO:0032392)3.04544883
70sister chromatid segregation (GO:0000819)3.04390258
71negative regulation of chromosome segregation (GO:0051985)3.03164014
72mRNA splicing, via spliceosome (GO:0000398)3.02030757
73RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02030757
74spindle checkpoint (GO:0031577)3.01749231
75nuclear envelope organization (GO:0006998)3.01743960
76protein localization to chromosome (GO:0034502)3.01565107
77RNA splicing, via transesterification reactions (GO:0000375)3.01208025
78macromolecular complex disassembly (GO:0032984)3.00745929
79establishment of chromosome localization (GO:0051303)3.00241721
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.99822302
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.99680013
82spindle assembly checkpoint (GO:0071173)2.98311989
83positive regulation of chromosome segregation (GO:0051984)2.97654864
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97510649
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.96596501
86negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96596501
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96596501
88negative regulation of sister chromatid segregation (GO:0033046)2.96596501
89G1/S transition of mitotic cell cycle (GO:0000082)2.94781445
90cell cycle G1/S phase transition (GO:0044843)2.94781445
91termination of RNA polymerase II transcription (GO:0006369)2.94635071
92negative regulation of mRNA processing (GO:0050686)2.94026457
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.93957485
94termination of RNA polymerase III transcription (GO:0006386)2.93957485
95cellular component biogenesis (GO:0044085)2.93650148
96mitotic spindle checkpoint (GO:0071174)2.92802864
97attachment of spindle microtubules to kinetochore (GO:0008608)2.92566674
98nuclear pore complex assembly (GO:0051292)2.92181245
99mitotic spindle assembly checkpoint (GO:0007094)2.92145417
100regulation of chromosome segregation (GO:0051983)2.89598037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57321551
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46104306
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.93587481
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90010198
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65127536
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19654079
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95729172
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83731825
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83139439
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.79679309
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.78431194
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78304242
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71046501
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54743430
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.54717775
16XRN2_22483619_ChIP-Seq_HELA_Human2.47006396
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.46666591
18AR_21909140_ChIP-Seq_LNCAP_Human2.32237168
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18571669
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17279301
21VDR_23849224_ChIP-Seq_CD4+_Human2.13039375
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06451343
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.98546228
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96125222
25FOXP3_21729870_ChIP-Seq_TREG_Human1.87603304
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87412871
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86806293
28GABP_19822575_ChIP-Seq_HepG2_Human1.84813129
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84253234
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82637576
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81388988
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81314317
33MYC_22102868_ChIP-Seq_BL_Human1.81087664
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80627302
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79982553
36DCP1A_22483619_ChIP-Seq_HELA_Human1.77792689
37TTF2_22483619_ChIP-Seq_HELA_Human1.77147687
38CIITA_25753668_ChIP-Seq_RAJI_Human1.75232697
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75049392
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64901042
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64281551
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59779990
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.58412602
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57295158
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54268154
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52329541
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48800406
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48191652
49KDM5A_27292631_Chip-Seq_BREAST_Human1.44797384
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43278308
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40957650
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38738200
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38123085
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.33019095
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31299578
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30824652
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29904255
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29845655
59ELK1_19687146_ChIP-ChIP_HELA_Human1.29305273
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26936824
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.26101981
62VDR_21846776_ChIP-Seq_THP-1_Human1.25319644
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22872781
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21081395
65* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20191076
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20177372
67ZNF263_19887448_ChIP-Seq_K562_Human1.18613901
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17876220
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17522068
70SCL_19346495_ChIP-Seq_HPC-7_Human1.17352558
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15717478
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12221007
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11034953
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08002173
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.05614136
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05154462
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04313354
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00077199
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98276753
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97535591
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97034550
82MYC_18940864_ChIP-ChIP_HL60_Human0.96357229
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95417603
84SPI1_23547873_ChIP-Seq_NB4_Human0.94910264
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93886217
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92160938
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88887723
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.88440039
89TFEB_21752829_ChIP-Seq_HELA_Human0.86418219
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84623916
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84540084
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83746657
93MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82764168
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82647576
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82556487
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81886846
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81097143
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80174190
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79333333
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74956597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.78762703
2MP0004957_abnormal_blastocyst_morpholog4.82525484
3MP0003111_abnormal_nucleus_morphology4.56529235
4MP0010094_abnormal_chromosome_stability4.35231929
5MP0008057_abnormal_DNA_replication4.11987983
6MP0003077_abnormal_cell_cycle4.00328314
7MP0003123_paternal_imprinting3.46075975
8MP0008932_abnormal_embryonic_tissue3.14709258
9MP0002396_abnormal_hematopoietic_system3.10116077
10MP0001730_embryonic_growth_arrest2.80643287
11MP0008007_abnormal_cellular_replicative2.68340396
12MP0008058_abnormal_DNA_repair2.51472446
13MP0001545_abnormal_hematopoietic_system2.38865113
14MP0005397_hematopoietic_system_phenotyp2.38865113
15* MP0005380_embryogenesis_phenotype2.20199223
16* MP0001672_abnormal_embryogenesis/_devel2.20199223
17MP0004808_abnormal_hematopoietic_stem2.17483291
18MP0000350_abnormal_cell_proliferation2.12766850
19MP0002084_abnormal_developmental_patter1.96137486
20* MP0003984_embryonic_growth_retardation1.95161300
21* MP0001697_abnormal_embryo_size1.94328779
22MP0010352_gastrointestinal_tract_polyps1.89823567
23* MP0002088_abnormal_embryonic_growth/wei1.89127978
24MP0002080_prenatal_lethality1.87459888
25MP0002234_abnormal_pharynx_morphology1.86358325
26MP0003567_abnormal_fetal_cardiomyocyte1.84370570
27MP0002086_abnormal_extraembryonic_tissu1.82299064
28MP0003890_abnormal_embryonic-extraembry1.70062144
29MP0000490_abnormal_crypts_of1.69553150
30MP0003786_premature_aging1.69040021
31* MP0002085_abnormal_embryonic_tissue1.65321851
32MP0000313_abnormal_cell_death1.63327085
33MP0008877_abnormal_DNA_methylation1.58108946
34MP0003121_genomic_imprinting1.49396508
35MP0003119_abnormal_digestive_system1.43502114
36MP0004197_abnormal_fetal_growth/weight/1.42416024
37MP0000465_gastrointestinal_hemorrhage1.32656971
38MP0001293_anophthalmia1.31262595
39MP0003718_maternal_effect1.31069034
40MP0010307_abnormal_tumor_latency1.30683518
41MP0002019_abnormal_tumor_incidence1.30547649
42MP0003221_abnormal_cardiomyocyte_apopto1.28339137
43MP0009333_abnormal_splenocyte_physiolog1.25999142
44MP0002722_abnormal_immune_system1.17587487
45MP0000703_abnormal_thymus_morphology1.14007715
46MP0010030_abnormal_orbit_morphology1.13237573
47MP0001915_intracranial_hemorrhage1.11261902
48MP0009278_abnormal_bone_marrow1.10324249
49MP0002398_abnormal_bone_marrow1.10166655
50MP0009672_abnormal_birth_weight1.08198058
51MP0000689_abnormal_spleen_morphology1.04234952
52MP0000358_abnormal_cell_content/1.00754683
53* MP0002111_abnormal_tail_morphology0.97618556
54MP0008789_abnormal_olfactory_epithelium0.93528691
55MP0004858_abnormal_nervous_system0.91175149
56MP0005384_cellular_phenotype0.89945799
57MP0001145_abnormal_male_reproductive0.87466338
58MP0006292_abnormal_olfactory_placode0.87135250
59MP0002429_abnormal_blood_cell0.87015595
60MP0005075_abnormal_melanosome_morpholog0.86784663
61MP0002653_abnormal_ependyma_morphology0.85999601
62MP0003878_abnormal_ear_physiology0.85640606
63MP0005377_hearing/vestibular/ear_phenot0.85640606
64MP0003937_abnormal_limbs/digits/tail_de0.84560601
65MP0005394_taste/olfaction_phenotype0.81110277
66MP0005499_abnormal_olfactory_system0.81110277
67MP0002210_abnormal_sex_determination0.80778481
68MP0005621_abnormal_cell_physiology0.80608323
69MP0003763_abnormal_thymus_physiology0.80220121
70MP0002132_abnormal_respiratory_system0.79751189
71MP0009840_abnormal_foam_cell0.78011034
72MP0008770_decreased_survivor_rate0.77667927
73MP0005464_abnormal_platelet_physiology0.77297197
74MP0009703_decreased_birth_body0.73004124
75MP0000428_abnormal_craniofacial_morphol0.72366091
76MP0000716_abnormal_immune_system0.70880659
77MP0000858_altered_metastatic_potential0.70630211
78MP0001986_abnormal_taste_sensitivity0.68886746
79MP0001853_heart_inflammation0.66923710
80MP0000653_abnormal_sex_gland0.66307250
81MP0000534_abnormal_ureter_morphology0.65917305
82MP0004133_heterotaxia0.65089123
83MP0002160_abnormal_reproductive_system0.64059755
84MP0003935_abnormal_craniofacial_develop0.63599376
85MP0002127_abnormal_cardiovascular_syste0.63353091
86MP0003315_abnormal_perineum_morphology0.63291142
87MP0009053_abnormal_anal_canal0.62668941
88MP0001929_abnormal_gametogenesis0.61989577
89MP0002938_white_spotting0.61073641
90MP0002092_abnormal_eye_morphology0.59604602
91* MP0002932_abnormal_joint_morphology0.57931235
92MP0002925_abnormal_cardiovascular_devel0.57612976
93MP0003186_abnormal_redox_activity0.55876707
94MP0002095_abnormal_skin_pigmentation0.54552884
95MP0005174_abnormal_tail_pigmentation0.54281302
96* MP0002114_abnormal_axial_skeleton0.51454011
97MP0000477_abnormal_intestine_morphology0.51366741
98* MP0003861_abnormal_nervous_system0.50999746
99MP0003806_abnormal_nucleotide_metabolis0.48124323
100MP0003656_abnormal_erythrocyte_physiolo0.47800933

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.07147348
2Abnormality of cells of the erythroid lineage (HP:0012130)4.99301349
3Abnormal number of erythroid precursors (HP:0012131)4.85818090
4Aplastic anemia (HP:0001915)4.51548226
5Breast hypoplasia (HP:0003187)4.43406094
6Reticulocytopenia (HP:0001896)4.32681611
7Colon cancer (HP:0003003)3.87578660
8Carpal bone hypoplasia (HP:0001498)3.79099088
9Rib fusion (HP:0000902)3.63271799
10Patellar aplasia (HP:0006443)3.58161724
11Macrocytic anemia (HP:0001972)3.52355308
12Cerebral hypomyelination (HP:0006808)3.48261673
13Aplasia/Hypoplasia of the patella (HP:0006498)3.37837132
14Pallor (HP:0000980)3.32724008
15Ependymoma (HP:0002888)3.30961291
16Oral leukoplakia (HP:0002745)3.29035100
17Medulloblastoma (HP:0002885)2.97918822
18Agnosia (HP:0010524)2.97479205
19Multiple enchondromatosis (HP:0005701)2.97361241
20Petechiae (HP:0000967)2.95774818
21Microretrognathia (HP:0000308)2.84540226
22Selective tooth agenesis (HP:0001592)2.80136100
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79668861
24Myelodysplasia (HP:0002863)2.79090617
25Rough bone trabeculation (HP:0100670)2.78206697
26Degeneration of anterior horn cells (HP:0002398)2.77435509
27Abnormality of the anterior horn cell (HP:0006802)2.77435509
28Impulsivity (HP:0100710)2.72860904
29Absent radius (HP:0003974)2.68577270
30Absent forearm bone (HP:0003953)2.53509127
31Aplasia involving forearm bones (HP:0009822)2.53509127
32Prominent nose (HP:0000448)2.50527966
33Facial hemangioma (HP:0000329)2.43347948
34Abnormality of the labia minora (HP:0012880)2.36883450
3511 pairs of ribs (HP:0000878)2.34523045
36Bone marrow hypocellularity (HP:0005528)2.33608558
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33407107
38Entropion (HP:0000621)2.33352343
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.31473788
40Pelvic girdle muscle weakness (HP:0003749)2.31332566
41Abnormality of the umbilical cord (HP:0010881)2.30292518
42Pendular nystagmus (HP:0012043)2.28679136
43Short middle phalanx of the 5th finger (HP:0004220)2.27144721
44Slender long bone (HP:0003100)2.25433810
45Chromsome breakage (HP:0040012)2.24545020
46Muscle fiber atrophy (HP:0100295)2.24105677
47Basal cell carcinoma (HP:0002671)2.22214780
48Hemivertebrae (HP:0002937)2.22093598
49Rhabdomyosarcoma (HP:0002859)2.20709390
50Missing ribs (HP:0000921)2.20643915
51Premature ovarian failure (HP:0008209)2.20474753
52Irregular epiphyses (HP:0010582)2.20309818
53CNS hypomyelination (HP:0003429)2.19657424
54Absent thumb (HP:0009777)2.19599328
55Abnormal platelet function (HP:0011869)2.17158560
56Impaired platelet aggregation (HP:0003540)2.17158560
57Neoplasm of the oral cavity (HP:0100649)2.16859825
58Meckel diverticulum (HP:0002245)2.14819285
59Progressive muscle weakness (HP:0003323)2.14071171
60Trismus (HP:0000211)2.13976241
61Asplenia (HP:0001746)2.12692001
62IgM deficiency (HP:0002850)2.11192141
63Acute lymphatic leukemia (HP:0006721)2.10368762
64Abnormality of the ileum (HP:0001549)2.10046784
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.09793370
66Absent epiphyses (HP:0010577)2.09793370
67Neoplasm of the pancreas (HP:0002894)2.09699975
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09482595
69Premature graying of hair (HP:0002216)2.07376035
70Glossoptosis (HP:0000162)2.06532901
71Thrombocytosis (HP:0001894)2.06063249
72Atresia of the external auditory canal (HP:0000413)2.05687766
73Abnormality of chromosome stability (HP:0003220)2.04229426
74Shawl scrotum (HP:0000049)2.03503136
75Megaloblastic anemia (HP:0001889)2.02832030
76Proximal placement of thumb (HP:0009623)2.01168741
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.01042222
78Pancytopenia (HP:0001876)1.98770734
79Amaurosis fugax (HP:0100576)1.96461150
80Hypoplasia of the radius (HP:0002984)1.96136047
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.95409800
82Aplasia/hypoplasia of the humerus (HP:0006507)1.94378918
83Secondary amenorrhea (HP:0000869)1.94287662
84Abnormality of the preputium (HP:0100587)1.93228648
85Abnormality of reticulocytes (HP:0004312)1.93225755
86Horseshoe kidney (HP:0000085)1.90310088
87Poikiloderma (HP:0001029)1.89933701
88Prolonged bleeding time (HP:0003010)1.88815742
89Abnormality of the musculature of the pelvis (HP:0001469)1.85369131
90Abnormality of the hip-girdle musculature (HP:0001445)1.85369131
91Squamous cell carcinoma (HP:0002860)1.84813176
92Breast aplasia (HP:0100783)1.84442036
93Cellular immunodeficiency (HP:0005374)1.83636275
94Back pain (HP:0003418)1.83187964
95Increased nuchal translucency (HP:0010880)1.83153182
96Deviation of the thumb (HP:0009603)1.83041721
97Personality changes (HP:0000751)1.82280089
98Abnormal trabecular bone morphology (HP:0100671)1.82141985
99Cleft eyelid (HP:0000625)1.81695130
100Overlapping toe (HP:0001845)1.81682477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.68667217
2BUB14.52128574
3STK164.22897988
4NME24.03621572
5LATS23.20388337
6CDC73.09417116
7NEK22.68164758
8TSSK62.65506599
9PLK42.53609781
10EEF2K2.28384585
11BRSK22.27075148
12SCYL22.24060396
13TESK22.16803407
14MKNK11.94816786
15VRK11.86415749
16SRPK11.84800051
17RPS6KB21.84568135
18TTK1.81260869
19DYRK31.79940447
20PLK11.76147757
21CDK71.65412362
22NEK11.62508757
23MKNK21.52413217
24ALK1.52110324
25PASK1.51614351
26PIM21.42713728
27AURKB1.41075031
28CDK41.38181954
29ATR1.36037829
30PAK41.34366895
31PLK31.31415661
32BRSK11.29020102
33EIF2AK11.28418492
34MAP3K81.26659093
35RPS6KA41.24893363
36STK101.17390148
37ACVR1B1.07071518
38TGFBR11.05711891
39CHEK11.02158528
40AURKA0.98279684
41TLK10.97174074
42MAP4K10.96994935
43MATK0.91009849
44KIT0.90242335
45CHEK20.89275064
46PAK10.87554371
47PIM10.86582626
48LRRK20.83983499
49AKT30.83905087
50KDR0.82783858
51DAPK10.79329256
52CDK190.78648108
53TRIB30.77973400
54CCNB10.76739319
55CDK20.75617836
56MAPKAPK30.74390573
57MAP3K110.74246966
58STK40.74017221
59BTK0.73284992
60CDK120.69296503
61PKN20.65764963
62STK30.61765292
63CSNK2A20.61356538
64CDK60.58712114
65GRK60.57478412
66CLK10.57249024
67MAPKAPK50.56181123
68ATM0.53631975
69EIF2AK30.52682152
70CDK80.51319315
71RAF10.49133873
72CSNK2A10.48802533
73CDK10.48434557
74CSNK1E0.48342630
75MAP3K100.48000780
76MAP2K30.47365819
77RIPK10.47089624
78ZAK0.43887155
79PAK20.42343352
80BRD40.41841108
81TEC0.41580851
82CSNK1G30.38696764
83ILK0.36842842
84AKT20.35095306
85RPS6KA50.34861257
86MAP3K50.34346343
87EPHA20.30550119
88TAOK10.30466284
89MAP3K60.29422426
90MTOR0.29186437
91PNCK0.28967248
92PINK10.28031041
93MAPK40.23620729
94TAOK20.22848267
95BRAF0.19637719
96MAPK140.15373275
97PRKDC0.14702059
98PDK30.14311601
99PDK40.14311601
100CDK11A0.13403801

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.10704323
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12021851
3Ribosome_Homo sapiens_hsa030103.92963958
4Mismatch repair_Homo sapiens_hsa034303.87543343
5RNA polymerase_Homo sapiens_hsa030203.71250106
6Spliceosome_Homo sapiens_hsa030403.57978842
7RNA transport_Homo sapiens_hsa030133.35741135
8Cell cycle_Homo sapiens_hsa041102.89866924
9Base excision repair_Homo sapiens_hsa034102.88701198
10Vitamin B6 metabolism_Homo sapiens_hsa007502.85364784
11Proteasome_Homo sapiens_hsa030502.83510208
12Pyrimidine metabolism_Homo sapiens_hsa002402.66753000
13Homologous recombination_Homo sapiens_hsa034402.58881569
14Nucleotide excision repair_Homo sapiens_hsa034202.44689318
15One carbon pool by folate_Homo sapiens_hsa006702.42211888
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27759433
17Fanconi anemia pathway_Homo sapiens_hsa034601.77648516
18p53 signaling pathway_Homo sapiens_hsa041151.73331799
19Folate biosynthesis_Homo sapiens_hsa007901.66070816
20Basal transcription factors_Homo sapiens_hsa030221.64232176
21RNA degradation_Homo sapiens_hsa030181.59814610
22mRNA surveillance pathway_Homo sapiens_hsa030151.57642631
23Purine metabolism_Homo sapiens_hsa002301.38952126
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.30394507
25Pentose phosphate pathway_Homo sapiens_hsa000301.21814419
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20844866
27Oocyte meiosis_Homo sapiens_hsa041141.20631936
28Epstein-Barr virus infection_Homo sapiens_hsa051691.12485818
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09463895
30Biosynthesis of amino acids_Homo sapiens_hsa012301.07263224
31Thyroid cancer_Homo sapiens_hsa052161.05902878
32Non-homologous end-joining_Homo sapiens_hsa034501.03058928
33Small cell lung cancer_Homo sapiens_hsa052221.02107669
34Systemic lupus erythematosus_Homo sapiens_hsa053220.99241333
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.98422322
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.95299161
37Viral carcinogenesis_Homo sapiens_hsa052030.93193736
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82040475
39Selenocompound metabolism_Homo sapiens_hsa004500.74429099
40Herpes simplex infection_Homo sapiens_hsa051680.71406001
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70293306
42HTLV-I infection_Homo sapiens_hsa051660.66152481
43Antigen processing and presentation_Homo sapiens_hsa046120.63378791
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62707384
45N-Glycan biosynthesis_Homo sapiens_hsa005100.61668310
46Acute myeloid leukemia_Homo sapiens_hsa052210.60016446
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59529156
48Colorectal cancer_Homo sapiens_hsa052100.56045400
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56006675
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55581548
51MicroRNAs in cancer_Homo sapiens_hsa052060.53368758
52Carbon metabolism_Homo sapiens_hsa012000.49620225
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47552502
54Alcoholism_Homo sapiens_hsa050340.46737836
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45334743
56Chronic myeloid leukemia_Homo sapiens_hsa052200.44819971
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43035695
58mTOR signaling pathway_Homo sapiens_hsa041500.41897171
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39807392
60Non-small cell lung cancer_Homo sapiens_hsa052230.39634364
61Hepatitis B_Homo sapiens_hsa051610.38547122
62Apoptosis_Homo sapiens_hsa042100.37745985
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37368104
64Sulfur relay system_Homo sapiens_hsa041220.37056170
65Glutathione metabolism_Homo sapiens_hsa004800.33696713
66Legionellosis_Homo sapiens_hsa051340.33602476
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32009302
68Protein export_Homo sapiens_hsa030600.31647419
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.31408664
70* Pathways in cancer_Homo sapiens_hsa052000.29983001
71Hippo signaling pathway_Homo sapiens_hsa043900.29570159
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28016464
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24348436
74Fructose and mannose metabolism_Homo sapiens_hsa000510.24074647
75Regulation of autophagy_Homo sapiens_hsa041400.23792118
76HIF-1 signaling pathway_Homo sapiens_hsa040660.23013096
77Renin-angiotensin system_Homo sapiens_hsa046140.20156165
78Measles_Homo sapiens_hsa051620.20079611
79Shigellosis_Homo sapiens_hsa051310.19573975
80Basal cell carcinoma_Homo sapiens_hsa052170.19100170
81* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16382047
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.16137208
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16077698
84Notch signaling pathway_Homo sapiens_hsa043300.15849141
85Metabolic pathways_Homo sapiens_hsa011000.15353712
86Galactose metabolism_Homo sapiens_hsa000520.14383280
87B cell receptor signaling pathway_Homo sapiens_hsa046620.14380368
88Vitamin digestion and absorption_Homo sapiens_hsa049770.10705232
89TGF-beta signaling pathway_Homo sapiens_hsa043500.10231043
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10229683
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08854405
92Platelet activation_Homo sapiens_hsa046110.08777968
93Hedgehog signaling pathway_Homo sapiens_hsa043400.08517440
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08368970
95Hematopoietic cell lineage_Homo sapiens_hsa046400.08081015
96Endometrial cancer_Homo sapiens_hsa052130.07781818
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07386717
98Toxoplasmosis_Homo sapiens_hsa051450.07262535
99Bladder cancer_Homo sapiens_hsa052190.06796628
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06687290

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