FGF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.65440240
2chondrocyte proliferation (GO:0035988)5.29455867
3protein heterotrimerization (GO:0070208)5.17386588
4sequestering of extracellular ligand from receptor (GO:0035581)5.01514307
5white fat cell differentiation (GO:0050872)4.84716805
6paraxial mesoderm development (GO:0048339)4.68437229
7negative regulation of fatty acid transport (GO:2000192)4.52977806
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.48447854
9skin morphogenesis (GO:0043589)4.30323961
10mesenchymal-epithelial cell signaling (GO:0060638)4.26068821
11kidney mesenchyme development (GO:0072074)4.14970399
12cell adhesion mediated by integrin (GO:0033627)4.08774893
13positive regulation of endothelial cell apoptotic process (GO:2000353)4.04814272
14endodermal cell differentiation (GO:0035987)3.88380683
15anterior/posterior axis specification, embryo (GO:0008595)3.88253961
16protein localization to cell surface (GO:0034394)3.87315511
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82342951
18positive regulation of fatty acid oxidation (GO:0046321)3.78147997
19* cell migration involved in sprouting angiogenesis (GO:0002042)3.78129678
20regulation of sequestering of triglyceride (GO:0010889)3.75866430
21cellular response to vitamin D (GO:0071305)3.74511194
22metanephric mesenchyme development (GO:0072075)3.69717144
23cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.67104266
24positive regulation of macrophage activation (GO:0043032)3.66534139
25brown fat cell differentiation (GO:0050873)3.64430820
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.64393644
27positive regulation of fibroblast migration (GO:0010763)3.63703481
28type B pancreatic cell proliferation (GO:0044342)3.53092349
29wound healing, spreading of epidermal cells (GO:0035313)3.52274235
30collagen metabolic process (GO:0032963)3.48667844
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.48109391
32positive regulation of SMAD protein import into nucleus (GO:0060391)3.45266868
33heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.43974136
34bone trabecula formation (GO:0060346)3.42948707
35low-density lipoprotein particle clearance (GO:0034383)3.40448663
36collagen catabolic process (GO:0030574)3.39348303
37triglyceride catabolic process (GO:0019433)3.33844130
38dermatan sulfate biosynthetic process (GO:0030208)3.33520181
39multicellular organismal macromolecule metabolic process (GO:0044259)3.32912981
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.32155285
41axon extension involved in axon guidance (GO:0048846)3.32155285
42vascular endothelial growth factor signaling pathway (GO:0038084)3.29694887
43positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.28539987
44chondrocyte development (GO:0002063)3.27446593
45growth hormone receptor signaling pathway (GO:0060396)3.27169630
46negative regulation of smooth muscle cell migration (GO:0014912)3.26009648
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.25273161
48negative regulation of osteoblast proliferation (GO:0033689)3.24644352
49apoptotic cell clearance (GO:0043277)3.23173699
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.20618896
51plasma membrane repair (GO:0001778)3.18178809
52multicellular organismal metabolic process (GO:0044236)3.17395959
53* positive regulation of blood vessel endothelial cell migration (GO:0043536)3.16075926
54substrate-dependent cell migration (GO:0006929)3.15404892
55cell migration involved in heart development (GO:0060973)3.14676969
56regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.14129827
57extracellular matrix assembly (GO:0085029)3.13863284
58negative regulation of BMP signaling pathway (GO:0030514)3.13476845
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.11782246
60stress fiber assembly (GO:0043149)3.10909038
61craniofacial suture morphogenesis (GO:0097094)3.08923119
62glomerular visceral epithelial cell development (GO:0072015)3.08750475
63multicellular organismal catabolic process (GO:0044243)3.07396174
64positive regulation of osteoblast proliferation (GO:0033690)3.06998645
65positive regulation of extracellular matrix organization (GO:1903055)3.05901794
66cellular protein complex localization (GO:0034629)3.05380981
67hippo signaling (GO:0035329)3.04202116
68renal filtration (GO:0097205)3.03481843
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02737068
70positive regulation of natural killer cell differentiation (GO:0032825)3.02610030
71dermatan sulfate metabolic process (GO:0030205)3.02417427
72protein complex localization (GO:0031503)3.02153369
73extracellular matrix disassembly (GO:0022617)3.01681882
74regulation of tight junction assembly (GO:2000810)2.99168111
75cellular response to vitamin (GO:0071295)2.97182420
76endothelial cell morphogenesis (GO:0001886)2.96820858
77regulation of osteoblast proliferation (GO:0033688)2.96776608
78notochord development (GO:0030903)2.96485686
79pericardium development (GO:0060039)2.95799892
80nuclear pore complex assembly (GO:0051292)2.94496678
81regulation of gene silencing by RNA (GO:0060966)2.93077046
82regulation of posttranscriptional gene silencing (GO:0060147)2.93077046
83regulation of gene silencing by miRNA (GO:0060964)2.93077046
84tyrosine phosphorylation of STAT protein (GO:0007260)2.92719024
85glomerular filtration (GO:0003094)2.89676219
86basement membrane organization (GO:0071711)2.89488396
87acylglycerol catabolic process (GO:0046464)2.88453797
88neutral lipid catabolic process (GO:0046461)2.88453797
89inner ear receptor cell development (GO:0060119)2.87421956
90peptidyl-proline hydroxylation (GO:0019511)2.87355650
91adhesion of symbiont to host cell (GO:0044650)2.86566811
92virion attachment to host cell (GO:0019062)2.86566811
93cell-substrate junction assembly (GO:0007044)2.85705408
94regulation of transforming growth factor beta1 production (GO:0032908)2.84606098
95adherens junction assembly (GO:0034333)2.83309614
96positive regulation of catenin import into nucleus (GO:0035413)2.81529882
97sprouting angiogenesis (GO:0002040)2.81496823
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.81068192
99epoxygenase P450 pathway (GO:0019373)2.81009069
100mesodermal cell differentiation (GO:0048333)2.80820003
101regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80280304
102cellular response to growth hormone stimulus (GO:0071378)2.80105175
103negative regulation of chondrocyte differentiation (GO:0032331)2.79918036
104regulation of plasminogen activation (GO:0010755)2.78125992
105regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76665487
106positive regulation of astrocyte differentiation (GO:0048711)2.76321773
107UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76166726
108iron ion import (GO:0097286)2.75596888
109regulation of fatty acid beta-oxidation (GO:0031998)2.73172179
110negative regulation of cardiac muscle tissue development (GO:0055026)2.72745747
111focal adhesion assembly (GO:0048041)2.72626332
112cell-substrate adherens junction assembly (GO:0007045)2.72626332
113regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.72142867
114convergent extension (GO:0060026)2.71963995
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.70709424
116negative regulation of embryonic development (GO:0045992)2.70639617
117endocardial cushion development (GO:0003197)2.70453678
118valine metabolic process (GO:0006573)2.69782972
119negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.69553143
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.69484214
121fibril organization (GO:0097435)2.68701360
122positive regulation of epithelial to mesenchymal transition (GO:0010718)2.68574224
123keratan sulfate catabolic process (GO:0042340)2.68092594
124wound healing, spreading of cells (GO:0044319)2.67866671
125regulation of SMAD protein import into nucleus (GO:0060390)2.65890711
126negative regulation of cartilage development (GO:0061037)2.65170488
127cranial suture morphogenesis (GO:0060363)2.64127932
128lymphangiogenesis (GO:0001946)2.63148010
129regulation of cartilage development (GO:0061035)2.62891425
130extracellular fibril organization (GO:0043206)2.62648365
131regulation of integrin-mediated signaling pathway (GO:2001044)2.62181772
132muscle cell migration (GO:0014812)2.61608239
133outer ear morphogenesis (GO:0042473)2.61162260
134glomerular epithelial cell development (GO:0072310)2.60377856
135regulation of fatty acid oxidation (GO:0046320)2.59391124
136substrate adhesion-dependent cell spreading (GO:0034446)2.59155551
137protein hydroxylation (GO:0018126)2.59062198
138glomerular basement membrane development (GO:0032836)2.57528296
139cellular response to amino acid stimulus (GO:0071230)2.57280407
140hypotonic response (GO:0006971)2.57069282
141nucleotide-sugar biosynthetic process (GO:0009226)2.56925221
142axon extension (GO:0048675)2.56881925
143* extracellular matrix organization (GO:0030198)2.56063137
144regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.55629332
145epithelial cell-cell adhesion (GO:0090136)2.55228027
146blood vessel maturation (GO:0001955)2.54895460
147* extracellular structure organization (GO:0043062)2.54781467
148cellular response to lithium ion (GO:0071285)2.53842525
149regulation of macrophage cytokine production (GO:0010935)2.53610510
150positive regulation of glycogen biosynthetic process (GO:0045725)2.52966086
151positive regulation of fat cell differentiation (GO:0045600)2.50620284
152cellular response to interferon-alpha (GO:0035457)2.47541681
153positive regulation of cartilage development (GO:0061036)2.47193086
154regulation of chondrocyte differentiation (GO:0032330)2.46912315
155regulation of cholesterol storage (GO:0010885)2.46206761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.84283001
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58074976
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.45227203
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.78192639
5E2F7_22180533_ChIP-Seq_HELA_Human3.46691374
6CLOCK_20551151_ChIP-Seq_293T_Human3.05369523
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02185240
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98107356
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.96512815
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93858540
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.65404020
12* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.48871683
13CJUN_26792858_Chip-Seq_BT549_Human2.42809268
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.41854957
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.39356857
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.36117956
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31842583
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.29374040
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.28739453
20AR_21909140_ChIP-Seq_LNCAP_Human2.22685850
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16017986
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15720870
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.07688135
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.07318868
25PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03398788
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.02487837
27* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01554291
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.97110094
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.97110094
30* BRD4_25478319_ChIP-Seq_HGPS_Human1.95468974
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91383394
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84238731
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78268056
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74784030
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.74721314
36* SALL1_21062744_ChIP-ChIP_HESCs_Human1.74469782
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71979883
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71397101
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68405871
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67980276
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67340893
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62275949
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59928574
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59928574
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.58341774
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.56415854
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.54695905
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.54695905
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.53233672
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51499360
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49302864
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49302864
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49302864
54* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49213111
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.44605251
56TBX3_20139965_ChIP-Seq_MESCs_Mouse1.43744052
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43244151
58AR_21572438_ChIP-Seq_LNCaP_Human1.42654645
59* TP53_18474530_ChIP-ChIP_U2OS_Human1.41550291
60* NANOG_16153702_ChIP-ChIP_HESCs_Human1.35380920
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35250987
62* TP53_16413492_ChIP-PET_HCT116_Human1.34890643
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34037587
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33729448
65* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.33191396
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33174096
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31403726
68* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28665716
69* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28474225
70RXR_22108803_ChIP-Seq_LS180_Human1.28181385
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.27913375
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26646871
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25963867
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.25878909
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25852477
76SOX2_20726797_ChIP-Seq_SW620_Human1.25196831
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24438405
78VDR_24787735_ChIP-Seq_THP-1_Human1.23849610
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23096640
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22675817
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21902628
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19427634
83* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18114188
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16017907
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13492706
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13323179
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.11505149
88TP53_22127205_ChIP-Seq_IMR90_Human1.11421816
89* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11203076
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.10918870
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09774541
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.09200911
93BCAT_22108803_ChIP-Seq_LS180_Human1.08929627
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08675296
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08419396
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07447802
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03469541
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.02413700
99* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02410692
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02287456
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.01822561
102RUNX_20019798_ChIP-Seq_JUKART_Human1.01509875
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00111133
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99905442
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99046072
106GATA1_22025678_ChIP-Seq_K562_Human0.98719172
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98688953
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97806207
109EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97652506
110RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97652506
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97527203
112SOX9_26525672_Chip-Seq_HEART_Mouse0.97068631
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96676973
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.96446453
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96317874
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96129512
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95180721
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95099169
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94731684
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94689028
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93262386
122* SOX2_16153702_ChIP-ChIP_HESCs_Human0.92997354
123* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92827034
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.91836998
125GBX2_23144817_ChIP-Seq_PC3_Human0.91708091
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91571466
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91038519
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.90503892
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.90297119
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90291262
131NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89189062
132TP63_23658742_ChIP-Seq_EP156T_Human0.87749179
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.87666670
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86799149
135* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86626302
136AHR_22903824_ChIP-Seq_MCF-7_Human0.86518815
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86268269
138* ATF3_27146783_Chip-Seq_COLON_Human0.85967581
139SA1_22415368_ChIP-Seq_MEFs_Mouse0.85679031
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85371875
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.85259552
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84953459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.08041661
2MP0005275_abnormal_skin_tensile4.61745455
3MP0005503_abnormal_tendon_morphology4.16948309
4MP0003705_abnormal_hypodermis_morpholog3.78646889
5MP0003279_aneurysm3.53671734
6MP0003941_abnormal_skin_development3.41969242
7MP0001958_emphysema3.24562219
8MP0004185_abnormal_adipocyte_glucose2.77018015
9MP0004130_abnormal_muscle_cell2.65216707
10MP0004272_abnormal_basement_membrane2.58945947
11MP0005670_abnormal_white_adipose2.47376344
12MP0009384_cardiac_valve_regurgitation2.46277638
13MP0005666_abnormal_adipose_tissue2.34485385
14MP0003566_abnormal_cell_adhesion2.27229721
15MP0000013_abnormal_adipose_tissue2.03836018
16MP0005375_adipose_tissue_phenotype1.96431012
17MP0005623_abnormal_meninges_morphology1.93448450
18MP0010352_gastrointestinal_tract_polyps1.90655656
19MP0010368_abnormal_lymphatic_system1.89312774
20MP0006054_spinal_hemorrhage1.86573763
21MP0002254_reproductive_system_inflammat1.82774955
22MP0009250_abnormal_appendicular_skeleto1.80849624
23MP0000003_abnormal_adipose_tissue1.75778376
24MP0005508_abnormal_skeleton_morphology1.67799697
25MP0002060_abnormal_skin_morphology1.66170045
26MP0003045_fibrosis1.65465793
27MP0002295_abnormal_pulmonary_circulatio1.62129104
28* MP0005023_abnormal_wound_healing1.60736630
29MP0001299_abnormal_eye_distance/1.58102830
30MP0001348_abnormal_lacrimal_gland1.57565881
31MP0000751_myopathy1.51415860
32MP0003300_gastrointestinal_ulcer1.49483699
33* MP0003091_abnormal_cell_migration1.48419074
34MP0002108_abnormal_muscle_morphology1.45311709
35MP0002933_joint_inflammation1.44598529
36MP0005257_abnormal_intraocular_pressure1.44031429
37MP0000534_abnormal_ureter_morphology1.39050857
38MP0003828_pulmonary_edema1.37811686
39MP0003937_abnormal_limbs/digits/tail_de1.37109032
40MP0000733_abnormal_muscle_development1.36128577
41MP0001879_abnormal_lymphatic_vessel1.35533373
42MP0004084_abnormal_cardiac_muscle1.34347945
43MP0002168_other_aberrant_phenotype1.33442875
44MP0000750_abnormal_muscle_regeneration1.32099303
45MP0004858_abnormal_nervous_system1.31529136
46MP0004134_abnormal_chest_morphology1.30020431
47MP0002896_abnormal_bone_mineralization1.25541333
48MP0003385_abnormal_body_wall1.23263521
49MP0000767_abnormal_smooth_muscle1.21071152
50MP0003950_abnormal_plasma_membrane1.20677025
51* MP0008775_abnormal_heart_ventricle1.18065410
52MP0000163_abnormal_cartilage_morphology1.17572812
53MP0001243_abnormal_dermal_layer1.17519154
54MP0005390_skeleton_phenotype1.17205333
55MP0005330_cardiomyopathy1.16048526
56MP0004087_abnormal_muscle_fiber1.15836697
57MP0009780_abnormal_chondrocyte_physiolo1.15076250
58MP0001542_abnormal_bone_strength1.14776420
59MP0005171_absent_coat_pigmentation1.14476439
60MP0006138_congestive_heart_failure1.13389530
61MP0000749_muscle_degeneration1.13150827
62MP0002971_abnormal_brown_adipose1.13016336
63MP0002115_abnormal_skeleton_extremities1.12879940
64MP0000432_abnormal_head_morphology1.12165877
65MP0005076_abnormal_cell_differentiation1.09399339
66MP0001849_ear_inflammation1.07343797
67MP0000759_abnormal_skeletal_muscle1.07285460
68MP0002837_dystrophic_cardiac_calcinosis1.07223522
69MP0002697_abnormal_eye_size1.06761733
70MP0000762_abnormal_tongue_morphology1.06266093
71MP0010386_abnormal_urinary_bladder1.05396977
72MP0002282_abnormal_trachea_morphology1.05369096
73MP0002998_abnormal_bone_remodeling1.03759049
74MP0008004_abnormal_stomach_pH1.03581132
75MP0003283_abnormal_digestive_organ1.03163370
76MP0001533_abnormal_skeleton_physiology1.02793554
77MP0009115_abnormal_fat_cell1.00055826
78MP0008932_abnormal_embryonic_tissue0.99980254
79MP0002133_abnormal_respiratory_system0.99558671
80MP0005388_respiratory_system_phenotype0.99558671
81MP0003724_increased_susceptibility_to0.98269538
82MP0005197_abnormal_uvea_morphology0.97144676
83MP0002113_abnormal_skeleton_development0.97143324
84MP0002128_abnormal_blood_circulation0.96035031
85MP0004233_abnormal_muscle_weight0.93521362
86MP0005385_cardiovascular_system_phenoty0.92937293
87MP0001544_abnormal_cardiovascular_syste0.92937293
88MP0003755_abnormal_palate_morphology0.92227101
89MP0010630_abnormal_cardiac_muscle0.91507322
90* MP0005620_abnormal_muscle_contractility0.91366138
91MP0003646_muscle_fatigue0.90867328
92MP0002877_abnormal_melanocyte_morpholog0.89605704
93MP0000049_abnormal_middle_ear0.89153095
94MP0010030_abnormal_orbit_morphology0.88960138
95MP0002972_abnormal_cardiac_muscle0.88524615
96MP0001177_atelectasis0.87909297
97MP0002084_abnormal_developmental_patter0.86481118
98MP0005164_abnormal_response_to0.85899869
99MP0004484_altered_response_of0.84777339
100* MP0005595_abnormal_vascular_smooth0.84605146
101MP0001915_intracranial_hemorrhage0.84002300
102MP0003959_abnormal_lean_body0.81497998
103* MP0001614_abnormal_blood_vessel0.79252555
104MP0002085_abnormal_embryonic_tissue0.79099533
105MP0001881_abnormal_mammary_gland0.78451820
106MP0002166_altered_tumor_susceptibility0.78251804
107MP0004957_abnormal_blastocyst_morpholog0.78023824
108MP0004036_abnormal_muscle_relaxation0.77770979
109MP0003795_abnormal_bone_structure0.77176553
110MP0003115_abnormal_respiratory_system0.76433306
111* MP0000343_altered_response_to0.75126670
112MP0000462_abnormal_digestive_system0.74932977
113MP0003935_abnormal_craniofacial_develop0.74824783
114MP0001175_abnormal_lung_morphology0.74609382
115MP0001661_extended_life_span0.74496800
116MP0005369_muscle_phenotype0.73805320
117MP0002970_abnormal_white_adipose0.73618894
118MP0009053_abnormal_anal_canal0.73396308
119MP0000428_abnormal_craniofacial_morphol0.72534544
120MP0005334_abnormal_fat_pad0.71789772
121MP0000537_abnormal_urethra_morphology0.71112453
122MP0002114_abnormal_axial_skeleton0.71056418
123MP0003448_altered_tumor_morphology0.70522880
124MP0005193_abnormal_anterior_eye0.69350114
125* MP0002925_abnormal_cardiovascular_devel0.69048437
126MP0002111_abnormal_tail_morphology0.68715789
127MP0001286_abnormal_eye_development0.68697898
128MP0008007_abnormal_cellular_replicative0.68122712
129MP0003942_abnormal_urinary_system0.66919930
130MP0009672_abnormal_birth_weight0.66449529
131MP0003111_abnormal_nucleus_morphology0.65233244
132MP0002116_abnormal_craniofacial_bone0.64990671
133MP0000467_abnormal_esophagus_morphology0.64593617
134MP0001293_anophthalmia0.64344567
135MP0002233_abnormal_nose_morphology0.63179709
136MP0002092_abnormal_eye_morphology0.61549420
137MP0002177_abnormal_outer_ear0.61158779
138MP0010307_abnormal_tumor_latency0.57497322
139MP0003890_abnormal_embryonic-extraembry0.57362698
140MP0001730_embryonic_growth_arrest0.57138309
141MP0002932_abnormal_joint_morphology0.56057612

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.89292031
2Premature rupture of membranes (HP:0001788)6.73791654
3Aortic dissection (HP:0002647)4.84250933
4Aortic aneurysm (HP:0004942)4.84231944
5Shallow orbits (HP:0000586)4.45643624
6Broad metatarsal (HP:0001783)4.06129811
7Peritonitis (HP:0002586)4.05026481
8Cerebral aneurysm (HP:0004944)3.98136944
9Soft skin (HP:0000977)3.90625631
10Atrophic scars (HP:0001075)3.89520294
11Dilatation of the ascending aorta (HP:0005111)3.75311527
12Ankle contracture (HP:0006466)3.49502529
13Cervical subluxation (HP:0003308)3.38603900
14Fragile skin (HP:0001030)3.36657380
15Bladder diverticulum (HP:0000015)3.34251291
16Mitral valve prolapse (HP:0001634)3.33378529
17Increased connective tissue (HP:0009025)3.25294971
18Spinal rigidity (HP:0003306)3.15742553
19Type 1 muscle fiber predominance (HP:0003803)3.12801796
20Genu recurvatum (HP:0002816)3.10355878
21Neonatal short-limb short stature (HP:0008921)3.08845416
22Overgrowth (HP:0001548)3.01738612
23Wormian bones (HP:0002645)3.01599827
24Vascular tortuosity (HP:0004948)2.88554154
25Blue sclerae (HP:0000592)2.81471481
26Hypoplastic ischia (HP:0003175)2.80997811
27Follicular hyperkeratosis (HP:0007502)2.73514390
28Biconcave vertebral bodies (HP:0004586)2.68391258
29Hyperextensible skin (HP:0000974)2.67807511
30Vertebral compression fractures (HP:0002953)2.62186261
31Wrist flexion contracture (HP:0001239)2.59151782
32Aneurysm (HP:0002617)2.58109300
33Abnormality of dentin (HP:0010299)2.58053928
34Increased density of long bones (HP:0006392)2.51315327
35Ectopia lentis (HP:0001083)2.48799336
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44989966
37Hypoventilation (HP:0002791)2.44071877
38Arterial tortuosity (HP:0005116)2.43927780
39Aortic valve stenosis (HP:0001650)2.43007042
40Osteolytic defects of the hand bones (HP:0009699)2.40882052
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.40882052
42Abnormality of the ischium (HP:0003174)2.38837017
43Wide anterior fontanel (HP:0000260)2.38507641
44Infantile muscular hypotonia (HP:0008947)2.36996046
45Osteoarthritis (HP:0002758)2.35997425
46Reduced subcutaneous adipose tissue (HP:0003758)2.35813770
47Bowel diverticulosis (HP:0005222)2.35196377
48Myocardial infarction (HP:0001658)2.30960741
49Increased variability in muscle fiber diameter (HP:0003557)2.29150426
50Flat cornea (HP:0007720)2.26623503
51Cupped ribs (HP:0000887)2.25328421
52Camptodactyly of toe (HP:0001836)2.24232529
53Round ear (HP:0100830)2.23630633
54Muscle fiber splitting (HP:0003555)2.22585919
55Abnormal delivery (HP:0001787)2.22214343
56Joint laxity (HP:0001388)2.18022927
57Vitreoretinal degeneration (HP:0000655)2.17961529
58Renal duplication (HP:0000075)2.17588132
59Hyporeflexia of lower limbs (HP:0002600)2.17070186
60Mesomelia (HP:0003027)2.16679820
61Elbow flexion contracture (HP:0002987)2.16644915
62Mitral regurgitation (HP:0001653)2.14389591
63Limb-girdle muscle weakness (HP:0003325)2.12925002
64Right ventricular cardiomyopathy (HP:0011663)2.12188632
65Mitral stenosis (HP:0001718)2.12077553
66Abnormality of skeletal muscle fiber size (HP:0012084)2.10202104
67Scapular winging (HP:0003691)2.08980298
68Venous abnormality (HP:0002624)2.08790081
69Acanthosis nigricans (HP:0000956)2.07786100
70Cardiovascular calcification (HP:0011915)2.07646343
71Mildly elevated creatine phosphokinase (HP:0008180)2.07234270
72Abnormality of the acetabulum (HP:0003170)2.06160314
73Spinal cord lesions (HP:0100561)2.05558249
74Syringomyelia (HP:0003396)2.05558249
75Broad ribs (HP:0000885)2.05322008
76Deviation of the hallux (HP:0010051)2.05050652
77Spondylolisthesis (HP:0003302)2.04015900
78Breech presentation (HP:0001623)2.03751250
79Short nail (HP:0001799)2.01364816
80Slender build (HP:0001533)1.98951574
81Mild short stature (HP:0003502)1.98429690
82Bell-shaped thorax (HP:0001591)1.98233462
83Persistence of primary teeth (HP:0006335)1.97758467
84Rectal prolapse (HP:0002035)1.96784404
85Arnold-Chiari malformation (HP:0002308)1.96707941
86Delayed cranial suture closure (HP:0000270)1.94693282
87Broad long bones (HP:0005622)1.93043045
88Coxa vara (HP:0002812)1.92958691
89Hallux valgus (HP:0001822)1.92784912
90Epiphyseal dysplasia (HP:0002656)1.92610569
91Exostoses (HP:0100777)1.91952874
92Short 4th metacarpal (HP:0010044)1.88898387
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88898387
94Nonimmune hydrops fetalis (HP:0001790)1.88300557
95Disproportionate tall stature (HP:0001519)1.88237588
96Ulnar bowing (HP:0003031)1.88067229
97Abnormality of the peritoneum (HP:0002585)1.87411155
98Radial bowing (HP:0002986)1.87257653
99Abnormality of the 4th metacarpal (HP:0010012)1.86973078
100Protruding ear (HP:0000411)1.86919875
101Narrow palate (HP:0000189)1.84301421
102Decreased subcutaneous fat (HP:0001002)1.84240949
103Limited elbow extension (HP:0001377)1.83051031
104Delayed closure of the anterior fontanelle (HP:0001476)1.81223695
105Difficulty running (HP:0009046)1.80604950
106Absent frontal sinuses (HP:0002688)1.80535110
107Aortic regurgitation (HP:0001659)1.80464262
108Joint stiffness (HP:0001387)1.80315277
109Natal tooth (HP:0000695)1.79879253
110Striae distensae (HP:0001065)1.79768697
111Coronal craniosynostosis (HP:0004440)1.79365415
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77488591
113Selective tooth agenesis (HP:0001592)1.76888935
114Tarsal synostosis (HP:0008368)1.75903537
115Abnormality of proline metabolism (HP:0010907)1.75860771
116Hydroxyprolinuria (HP:0003080)1.75860771
117Knee flexion contracture (HP:0006380)1.75773878
118Lipoatrophy (HP:0100578)1.75732579
119Generalized amyotrophy (HP:0003700)1.75314835
120Aplasia of the phalanges of the hand (HP:0009802)1.74825243
121Pulmonic stenosis (HP:0001642)1.74766028
122Inguinal hernia (HP:0000023)1.73258406
123Redundant skin (HP:0001582)1.72855324
124Broad phalanx (HP:0006009)1.70824948
125Short middle phalanx of the 5th finger (HP:0004220)1.65948901
126Achilles tendon contracture (HP:0001771)1.64661144
127Spastic diplegia (HP:0001264)1.64234529
128Flared iliac wings (HP:0002869)1.63195495
129Turricephaly (HP:0000262)1.62136602
130Abnormality of oral frenula (HP:0000190)1.61978967
131Hyperacusis (HP:0010780)1.60502493
132Deformed tarsal bones (HP:0008119)1.59651024
133Calcaneovalgus deformity (HP:0001848)1.59071303
134Ankyloglossia (HP:0010296)1.58889946
135Overriding aorta (HP:0002623)1.58140827
136Short hallux (HP:0010109)1.58029954
137Insomnia (HP:0100785)1.57835844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.20971934
2DDR23.93761522
3TTN3.74983223
4LATS13.55823956
5SIK13.15939637
6NTRK12.86880887
7PDGFRA2.77458953
8ERBB42.65713847
9CAMK1D2.58417055
10DMPK2.54778531
11RIPK12.29399761
12AKT32.25879263
13EPHB22.20065763
14NEK92.18387392
15TTK1.99827454
16EPHA31.94000634
17PKN21.93725395
18CAMK1G1.88566580
19PIK3CA1.80278375
20LMTK21.74766669
21LATS21.72786034
22BRSK21.69118283
23JAK31.63380830
24CDC71.59162765
25FER1.57649964
26TGFBR21.55644509
27TRPM71.54637854
28ERN11.50973357
29PAK21.45374185
30STK31.45070271
31TSSK61.41573105
32FGFR31.32044402
33PLK31.31781355
34CDK91.22307784
35MYLK1.20177202
36STK381.19870859
37FGFR11.19052884
38PDGFRB1.18946097
39FGFR41.16991940
40PNCK1.15783364
41FGFR21.14673139
42LRRK21.13909231
43JAK11.12923895
44PAK61.11754191
45NME21.09867145
46PRKD31.08801874
47RPS6KA41.06298872
48CDK61.04167713
49PAK31.03123181
50TAF11.01813025
51PIK3CG0.99971578
52NUAK10.99437601
53BUB10.99298056
54PRKCH0.97329079
55STK38L0.95586072
56PLK20.93976025
57MELK0.91075167
58NEK10.90462872
59MKNK10.88931856
60FLT30.88577486
61MTOR0.87593156
62INSR0.86816516
63FRK0.84960640
64ABL20.84642380
65EEF2K0.84427664
66PTK20.84412681
67PRKD10.84122532
68CHEK20.83257574
69MOS0.83080045
70MAP3K130.82853311
71MKNK20.81874486
72EPHB10.81391071
73ROCK10.81296378
74PBK0.80074344
75MAP2K10.79835592
76DYRK30.77468461
77PRKAA20.76691277
78PTK2B0.74615186
79BRSK10.73182395
80MAP3K30.71936633
81BMX0.71927065
82DAPK30.71370442
83PRKG20.71094562
84PIM20.70673348
85PRKD20.68996510
86RET0.66075806
87NLK0.65708382
88IGF1R0.65111755
89PTK60.64645304
90LIMK10.64537610
91WEE10.63664500
92MAP3K100.62305394
93OBSCN0.62266569
94PLK10.61026520
95ZAP700.60295120
96ILK0.58598136
97TGFBR10.58467993
98AURKB0.57801122
99CDK80.57648533
100NEK20.57278748
101PAK40.55412464
102BRAF0.55287046
103PDK40.54017203
104PDK30.54017203
105TESK10.53027417
106CDC42BPA0.52869179
107PAK10.51898865
108PRKCE0.51860800
109PHKG20.51631769
110PHKG10.51631769
111MAP3K70.50787429
112MAP3K80.49817607
113ERBB30.49398856
114WNK10.48271608
115MAP2K30.47529097
116CAMKK20.46354143
117SMG10.46054989
118RPS6KA20.45753942
119MAP3K90.44595940
120CDK150.44465753
121ABL10.43828705
122ROCK20.43786880
123CDK180.41414468
124MET0.40941025
125CSK0.40818886
126CLK10.40433817
127KIT0.40339374
128CAMK2G0.40265137
129EPHA20.39522518
130CDK11A0.38955271
131SRC0.38342086
132TAOK10.38009096
133MST1R0.37492592
134TIE10.37395938
135CDK140.35641810
136EIF2AK30.35568630
137SCYL20.35534886
138STK100.35451087
139CDK120.35348151
140HCK0.35279904
141CHEK10.35115681
142STK40.34988844
143AURKA0.34330901
144STK240.33317677
145CDK70.32751354
146IRAK10.32129081
147GSK3A0.31323889
148ADRBK10.31301842
149KSR20.31064339
150MAPK70.30802030
151MARK20.30336133
152TAOK20.30164243
153PLK40.28656295

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.81147607
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.83389581
3Focal adhesion_Homo sapiens_hsa045102.78765481
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.30979582
5Dilated cardiomyopathy_Homo sapiens_hsa054142.29003218
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20911121
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.16192710
8* Proteoglycans in cancer_Homo sapiens_hsa052052.15531623
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98023546
10Protein digestion and absorption_Homo sapiens_hsa049741.91904790
11PPAR signaling pathway_Homo sapiens_hsa033201.86709468
12Adherens junction_Homo sapiens_hsa045201.84962062
13Viral myocarditis_Homo sapiens_hsa054161.81164065
14Small cell lung cancer_Homo sapiens_hsa052221.75390265
15Malaria_Homo sapiens_hsa051441.68594789
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65970289
17TGF-beta signaling pathway_Homo sapiens_hsa043501.61718627
18Amoebiasis_Homo sapiens_hsa051461.59242873
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53604339
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46679652
21* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44142511
22Nitrogen metabolism_Homo sapiens_hsa009101.44035781
23Chronic myeloid leukemia_Homo sapiens_hsa052201.43622703
24Fatty acid biosynthesis_Homo sapiens_hsa000611.43393897
25Bladder cancer_Homo sapiens_hsa052191.40744927
26Selenocompound metabolism_Homo sapiens_hsa004501.38160299
27Cell cycle_Homo sapiens_hsa041101.36516653
28Hippo signaling pathway_Homo sapiens_hsa043901.35036735
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.32624413
30MicroRNAs in cancer_Homo sapiens_hsa052061.27580299
31AMPK signaling pathway_Homo sapiens_hsa041521.25683992
32Vitamin B6 metabolism_Homo sapiens_hsa007501.25021715
33* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22389609
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.21430989
35HIF-1 signaling pathway_Homo sapiens_hsa040661.21129021
36Toxoplasmosis_Homo sapiens_hsa051451.17881945
37Caffeine metabolism_Homo sapiens_hsa002321.12073222
38Axon guidance_Homo sapiens_hsa043601.11842357
39Platelet activation_Homo sapiens_hsa046111.11646560
40Pancreatic cancer_Homo sapiens_hsa052121.10738487
41* Melanoma_Homo sapiens_hsa052181.07616234
42Insulin resistance_Homo sapiens_hsa049311.04923115
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04624379
44Glioma_Homo sapiens_hsa052141.04229542
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02971119
46Gap junction_Homo sapiens_hsa045401.02152856
47Basal cell carcinoma_Homo sapiens_hsa052170.99755636
48TNF signaling pathway_Homo sapiens_hsa046680.99619697
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98821232
50Renal cell carcinoma_Homo sapiens_hsa052110.98193464
51* Rap1 signaling pathway_Homo sapiens_hsa040150.96886753
52* Pathways in cancer_Homo sapiens_hsa052000.96212821
53Thyroid cancer_Homo sapiens_hsa052160.96045778
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.95480075
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95299290
56Prostate cancer_Homo sapiens_hsa052150.95059316
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94872875
58Non-homologous end-joining_Homo sapiens_hsa034500.94070917
59Propanoate metabolism_Homo sapiens_hsa006400.92830122
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.92561636
61Prion diseases_Homo sapiens_hsa050200.91441544
62One carbon pool by folate_Homo sapiens_hsa006700.90973279
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90679297
64Osteoclast differentiation_Homo sapiens_hsa043800.88677592
65Tight junction_Homo sapiens_hsa045300.88372179
66Hematopoietic cell lineage_Homo sapiens_hsa046400.86701073
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84565551
68Shigellosis_Homo sapiens_hsa051310.84496312
69Insulin signaling pathway_Homo sapiens_hsa049100.84316234
70HTLV-I infection_Homo sapiens_hsa051660.80861363
71Nucleotide excision repair_Homo sapiens_hsa034200.80288974
72p53 signaling pathway_Homo sapiens_hsa041150.80284952
73mTOR signaling pathway_Homo sapiens_hsa041500.76870076
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74136014
75Acute myeloid leukemia_Homo sapiens_hsa052210.74086378
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74041723
77Hepatitis B_Homo sapiens_hsa051610.73497246
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71861617
79Wnt signaling pathway_Homo sapiens_hsa043100.71726929
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71114572
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70923833
82* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70913781
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68687946
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.66368358
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66210125
86RNA transport_Homo sapiens_hsa030130.66032792
87Phototransduction_Homo sapiens_hsa047440.65322981
88Leishmaniasis_Homo sapiens_hsa051400.64793021
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63807466
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.63192686
91VEGF signaling pathway_Homo sapiens_hsa043700.63191222
92Colorectal cancer_Homo sapiens_hsa052100.62404537
93cAMP signaling pathway_Homo sapiens_hsa040240.61979742
94N-Glycan biosynthesis_Homo sapiens_hsa005100.61659547
95FoxO signaling pathway_Homo sapiens_hsa040680.61222330
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61189526
97* Ras signaling pathway_Homo sapiens_hsa040140.60940351
98Glucagon signaling pathway_Homo sapiens_hsa049220.60191191
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.59692483
100Fatty acid metabolism_Homo sapiens_hsa012120.58949350
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.55366351
102mRNA surveillance pathway_Homo sapiens_hsa030150.55355094
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54457615
104Biosynthesis of amino acids_Homo sapiens_hsa012300.54387355
105Mismatch repair_Homo sapiens_hsa034300.54080358
106Hedgehog signaling pathway_Homo sapiens_hsa043400.53967606
107Endometrial cancer_Homo sapiens_hsa052130.53722314
108Endocytosis_Homo sapiens_hsa041440.53387188
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53173741
110Glycerolipid metabolism_Homo sapiens_hsa005610.53166231
111ErbB signaling pathway_Homo sapiens_hsa040120.52282482
112Prolactin signaling pathway_Homo sapiens_hsa049170.51593784
113Ovarian steroidogenesis_Homo sapiens_hsa049130.50518413
114DNA replication_Homo sapiens_hsa030300.50322008
115Salmonella infection_Homo sapiens_hsa051320.49588472
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49466165
117Melanogenesis_Homo sapiens_hsa049160.48525189
118Galactose metabolism_Homo sapiens_hsa000520.48097249
119Renin-angiotensin system_Homo sapiens_hsa046140.47981743
120* MAPK signaling pathway_Homo sapiens_hsa040100.46952085
121Estrogen signaling pathway_Homo sapiens_hsa049150.46821548
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46191130
123Renin secretion_Homo sapiens_hsa049240.46155407
124Oxytocin signaling pathway_Homo sapiens_hsa049210.45482541
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44887319
126Lysine degradation_Homo sapiens_hsa003100.44059316
127Apoptosis_Homo sapiens_hsa042100.43657700
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43236586
129Dorso-ventral axis formation_Homo sapiens_hsa043200.42764173
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.42094531
131GnRH signaling pathway_Homo sapiens_hsa049120.42027018
132Sulfur metabolism_Homo sapiens_hsa009200.39388703
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37774890
134Basal transcription factors_Homo sapiens_hsa030220.37093390
135Oocyte meiosis_Homo sapiens_hsa041140.34492062
136Viral carcinogenesis_Homo sapiens_hsa052030.33165064
137Vibrio cholerae infection_Homo sapiens_hsa051100.32949211
138Alcoholism_Homo sapiens_hsa050340.28470396
139Pentose phosphate pathway_Homo sapiens_hsa000300.26465259

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