FGF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ovulation cycle (GO:0042698)7.94254242
2tyrosine phosphorylation of STAT protein (GO:0007260)6.77606683
3regulation of female gonad development (GO:2000194)6.54925027
4negative regulation of protein tyrosine kinase activity (GO:0061099)5.74359248
5positive regulation of neurological system process (GO:0031646)5.70362500
6regulation of transmission of nerve impulse (GO:0051969)5.32628901
7response to pheromone (GO:0019236)5.27585773
8regulation of neuron migration (GO:2001222)4.63876184
9regulation of gene silencing by RNA (GO:0060966)4.42954746
10regulation of posttranscriptional gene silencing (GO:0060147)4.42954746
11regulation of gene silencing by miRNA (GO:0060964)4.42954746
12establishment of integrated proviral latency (GO:0075713)4.34485183
13heterochromatin organization (GO:0070828)4.23476804
14polyamine biosynthetic process (GO:0006596)3.82626179
15protein localization to kinetochore (GO:0034501)3.71433644
16nuclear pore complex assembly (GO:0051292)3.69820519
17chromatin remodeling at centromere (GO:0031055)3.56944321
18negative regulation of neurological system process (GO:0031645)3.54388193
19notochord development (GO:0030903)3.41040573
20L-serine metabolic process (GO:0006563)3.39231570
21cell fate commitment involved in formation of primary germ layer (GO:0060795)3.37655686
22polyamine metabolic process (GO:0006595)3.36039694
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.23969981
24regulation of translation, ncRNA-mediated (GO:0045974)3.23969981
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23969981
26CENP-A containing nucleosome assembly (GO:0034080)3.21687766
27protein localization to chromosome, centromeric region (GO:0071459)3.17377867
28establishment of viral latency (GO:0019043)3.14645260
29pre-miRNA processing (GO:0031054)3.10128089
30nuclear pore organization (GO:0006999)3.04642741
31DNA replication-independent nucleosome organization (GO:0034724)2.97664492
32DNA replication-independent nucleosome assembly (GO:0006336)2.97664492
33serine family amino acid biosynthetic process (GO:0009070)2.96372653
34DNA replication checkpoint (GO:0000076)2.93460318
35regulation of helicase activity (GO:0051095)2.90125811
36ectodermal placode formation (GO:0060788)2.88888629
37regulation of mitotic spindle checkpoint (GO:1903504)2.87982656
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87982656
39peptidyl-threonine dephosphorylation (GO:0035970)2.87644887
40paraxial mesoderm development (GO:0048339)2.85926871
41regulation of centrosome cycle (GO:0046605)2.84691299
42protein complex localization (GO:0031503)2.81990527
43DNA unwinding involved in DNA replication (GO:0006268)2.80419828
44positive regulation of SMAD protein import into nucleus (GO:0060391)2.78474931
45histone H2B ubiquitination (GO:0033523)2.76711754
46hindbrain development (GO:0030902)2.73987208
47regulation of cell fate specification (GO:0042659)2.73114567
48DNA strand elongation involved in DNA replication (GO:0006271)2.72351543
49rRNA transcription (GO:0009303)2.70262606
50histone exchange (GO:0043486)2.63912927
51mitotic metaphase plate congression (GO:0007080)2.61622954
52regulation of translational fidelity (GO:0006450)2.60924037
53chromatin assembly (GO:0031497)2.58585176
54somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58335720
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.58335720
56single strand break repair (GO:0000012)2.58265019
57regulation of nuclear cell cycle DNA replication (GO:0033262)2.55759495
58establishment of monopolar cell polarity (GO:0061162)2.55637258
59establishment or maintenance of monopolar cell polarity (GO:0061339)2.55637258
60dorsal/ventral axis specification (GO:0009950)2.55572899
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.54880813
62termination of RNA polymerase III transcription (GO:0006386)2.54880813
63DNA double-strand break processing (GO:0000729)2.54779398
64chromatin assembly or disassembly (GO:0006333)2.53422584
65negative regulation of chromosome segregation (GO:0051985)2.53309895
66DNA strand elongation (GO:0022616)2.52623824
67cholesterol biosynthetic process (GO:0006695)2.51547090
68glycine metabolic process (GO:0006544)2.51034071
69DNA damage response, detection of DNA damage (GO:0042769)2.49699753
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48875119
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.48875119
72negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48875119
73negative regulation of mitotic sister chromatid separation (GO:2000816)2.48875119
74negative regulation of sister chromatid segregation (GO:0033046)2.48875119
75regulation of centrosome duplication (GO:0010824)2.47898763
76lung-associated mesenchyme development (GO:0060484)2.47759158
77nodal signaling pathway (GO:0038092)2.47387065
78pore complex assembly (GO:0046931)2.46987340
79maturation of 5.8S rRNA (GO:0000460)2.46423970
80lysine metabolic process (GO:0006553)2.45712941
81lysine catabolic process (GO:0006554)2.45712941
82negative regulation of androgen receptor signaling pathway (GO:0060766)2.45050103
83spinal cord development (GO:0021510)2.43938490
84DNA strand renaturation (GO:0000733)2.42310980
85mitotic chromosome condensation (GO:0007076)2.41252113
86histone arginine methylation (GO:0034969)2.40994004
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40688858
88ATP-dependent chromatin remodeling (GO:0043044)2.40617861
89telomere maintenance via telomerase (GO:0007004)2.40056602
90folic acid-containing compound biosynthetic process (GO:0009396)2.39642801
91regulation of chromosome segregation (GO:0051983)2.39033176
92cellular glucuronidation (GO:0052695)2.38661307
93cellular biogenic amine biosynthetic process (GO:0042401)2.37264991
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.36353136
95ATP synthesis coupled proton transport (GO:0015986)2.36353136
96telomere maintenance via semi-conservative replication (GO:0032201)2.34789768
97DNA topological change (GO:0006265)2.34389529
98DNA replication-dependent nucleosome assembly (GO:0006335)2.32878886
99DNA replication-dependent nucleosome organization (GO:0034723)2.32878886
100regulation of centriole replication (GO:0046599)2.32441998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80624624
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.74396750
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74258984
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48851789
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42172266
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.05831631
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.05831631
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.05831631
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00598183
10AR_21909140_ChIP-Seq_LNCAP_Human2.71767707
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61778732
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.45468431
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44967987
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31030785
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19891697
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06269904
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06223758
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04195665
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.03169547
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01379616
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97708257
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94025514
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92953907
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92051675
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.86045573
26* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84799492
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82604251
28* NANOG_16153702_ChIP-ChIP_HESCs_Human1.81262932
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81020144
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77756538
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73027131
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70915831
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70893346
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.68413940
35* SOX2_16153702_ChIP-ChIP_HESCs_Human1.67322586
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67177782
37ZNF263_19887448_ChIP-Seq_K562_Human1.66580507
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.63946636
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61655701
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57040340
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54312742
42TTF2_22483619_ChIP-Seq_HELA_Human1.53373466
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47516291
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.47412020
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47152957
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.45324061
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42342832
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40170620
49XRN2_22483619_ChIP-Seq_HELA_Human1.37575059
50IRF1_19129219_ChIP-ChIP_H3396_Human1.37293532
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34885094
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27994458
53* GABP_19822575_ChIP-Seq_HepG2_Human1.27752246
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24300712
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23800220
56MYC_18940864_ChIP-ChIP_HL60_Human1.23798990
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23428588
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21620028
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21567491
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20941935
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20774936
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20680142
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20384258
64ELK1_19687146_ChIP-ChIP_HELA_Human1.20280124
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19177301
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17740787
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17711492
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.17158065
69NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11267343
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09544835
71SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08070613
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04480330
73NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03897847
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02581634
75DCP1A_22483619_ChIP-Seq_HELA_Human1.01378772
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00443339
77KDM5A_27292631_Chip-Seq_BREAST_Human0.99803281
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96935170
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.96423726
80PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95231651
81POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94893481
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94664396
83FOXP3_21729870_ChIP-Seq_TREG_Human0.93283207
84POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93061833
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92967570
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92833479
87POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91078335
88VDR_22108803_ChIP-Seq_LS180_Human0.90832414
89ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90135621
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90048415
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90007171
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89015756
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88402877
94SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85506085
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85398204
96NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84331474
97NANOG_16518401_ChIP-PET_MESCs_Mouse0.83459775
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82844692
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80600953
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.79299785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology6.23578934
2MP0005187_abnormal_penis_morphology5.61357664
3MP0005646_abnormal_pituitary_gland4.38782241
4MP0003123_paternal_imprinting3.67055891
5MP0002254_reproductive_system_inflammat3.59580477
6MP0006292_abnormal_olfactory_placode3.24296202
7MP0003693_abnormal_embryo_hatching2.78204111
8MP0000613_abnormal_salivary_gland2.74801774
9MP0003787_abnormal_imprinting2.69096950
10MP0004957_abnormal_blastocyst_morpholog2.51734271
11MP0003941_abnormal_skin_development2.34026244
12MP0003122_maternal_imprinting2.28940420
13MP0003121_genomic_imprinting2.23006706
14MP0004133_heterotaxia2.21319679
15MP0004185_abnormal_adipocyte_glucose2.09611286
16MP0003111_abnormal_nucleus_morphology2.06031525
17MP0003718_maternal_effect1.99805873
18MP0008877_abnormal_DNA_methylation1.90478979
19MP0000537_abnormal_urethra_morphology1.82423919
20MP0003890_abnormal_embryonic-extraembry1.74085828
21MP0010094_abnormal_chromosome_stability1.72919461
22MP0003119_abnormal_digestive_system1.57942138
23MP0009672_abnormal_birth_weight1.47764453
24MP0001293_anophthalmia1.46351168
25MP0002233_abnormal_nose_morphology1.41338592
26MP0003937_abnormal_limbs/digits/tail_de1.41109887
27MP0008932_abnormal_embryonic_tissue1.38871874
28MP0002111_abnormal_tail_morphology1.38772943
29MP0003077_abnormal_cell_cycle1.29186013
30MP0002796_impaired_skin_barrier1.27898863
31MP0002697_abnormal_eye_size1.25152996
32MP0001188_hyperpigmentation1.24626369
33MP0000049_abnormal_middle_ear1.23928725
34MP0009379_abnormal_foot_pigmentation1.22994512
35MP0000566_synostosis1.21546441
36MP0001346_abnormal_lacrimal_gland1.15481952
37MP0009703_decreased_birth_body1.15451276
38MP0010030_abnormal_orbit_morphology1.15195319
39MP0000762_abnormal_tongue_morphology1.13323603
40MP0001286_abnormal_eye_development1.13236683
41MP0002089_abnormal_postnatal_growth/wei1.08267956
42MP0002085_abnormal_embryonic_tissue1.08089122
43MP0002084_abnormal_developmental_patter1.02545178
44MP0001177_atelectasis1.01862519
45MP0001348_abnormal_lacrimal_gland1.00566738
46MP0003115_abnormal_respiratory_system1.00509990
47MP0003283_abnormal_digestive_organ0.96496128
48MP0010234_abnormal_vibrissa_follicle0.96056291
49MP0000490_abnormal_crypts_of0.95761667
50MP0008007_abnormal_cellular_replicative0.93413096
51MP0003942_abnormal_urinary_system0.93181295
52MP0001730_embryonic_growth_arrest0.91544763
53MP0003755_abnormal_palate_morphology0.88337692
54MP0002210_abnormal_sex_determination0.88284109
55MP0000428_abnormal_craniofacial_morphol0.88057753
56MP0003861_abnormal_nervous_system0.87809339
57MP0003136_yellow_coat_color0.86880437
58MP0010352_gastrointestinal_tract_polyps0.86812246
59MP0004197_abnormal_fetal_growth/weight/0.86307153
60MP0008058_abnormal_DNA_repair0.86268518
61MP0001672_abnormal_embryogenesis/_devel0.85598875
62MP0005380_embryogenesis_phenotype0.85598875
63MP0008789_abnormal_olfactory_epithelium0.85303690
64MP0002249_abnormal_larynx_morphology0.82535961
65MP0001666_abnormal_nutrient_absorption0.80793810
66MP0005666_abnormal_adipose_tissue0.80318970
67MP0000350_abnormal_cell_proliferation0.76752233
68MP0000477_abnormal_intestine_morphology0.76633862
69MP0004264_abnormal_extraembryonic_tissu0.76512521
70MP0001697_abnormal_embryo_size0.76312737
71MP0003938_abnormal_ear_development0.74824927
72MP0000579_abnormal_nail_morphology0.74490135
73MP0008875_abnormal_xenobiotic_pharmacok0.74432005
74MP0004019_abnormal_vitamin_homeostasis0.74096209
75MP0009697_abnormal_copulation0.72206895
76MP0005085_abnormal_gallbladder_physiolo0.71189857
77MP0002080_prenatal_lethality0.70911005
78MP0003984_embryonic_growth_retardation0.70399883
79MP0002733_abnormal_thermal_nociception0.70364621
80MP0000432_abnormal_head_morphology0.70101431
81MP0002139_abnormal_hepatobiliary_system0.69935006
82MP0008961_abnormal_basal_metabolism0.69358221
83MP0001145_abnormal_male_reproductive0.68092131
84MP0005501_abnormal_skin_physiology0.67939300
85MP0003567_abnormal_fetal_cardiomyocyte0.67677779
86MP0009053_abnormal_anal_canal0.67370667
87MP0002088_abnormal_embryonic_growth/wei0.66427191
88MP0001485_abnormal_pinna_reflex0.65881041
89MP0002092_abnormal_eye_morphology0.65083241
90MP0006035_abnormal_mitochondrial_morpho0.64334057
91MP0005220_abnormal_exocrine_pancreas0.64206628
92MP0003868_abnormal_feces_composition0.63423395
93MP0001299_abnormal_eye_distance/0.62084305
94MP0003186_abnormal_redox_activity0.62030815
95MP0002116_abnormal_craniofacial_bone0.60546894
96MP0008057_abnormal_DNA_replication0.60362463
97MP0000653_abnormal_sex_gland0.58385119
98MP0000470_abnormal_stomach_morphology0.57046417
99MP0001929_abnormal_gametogenesis0.57000549
100MP0005365_abnormal_bile_salt0.56543768

Predicted human phenotypes

RankGene SetZ-score
1Anosmia (HP:0000458)6.16608203
2Hypogonadotrophic hypogonadism (HP:0000044)4.97876306
3Birth length less than 3rd percentile (HP:0003561)3.85134222
4Abnormal number of incisors (HP:0011064)3.43124075
5Enlarged penis (HP:0000040)3.36831153
6Pendular nystagmus (HP:0012043)3.32146334
7Abnormality of the labia minora (HP:0012880)3.25869730
8Delayed puberty (HP:0000823)3.16824138
9Septo-optic dysplasia (HP:0100842)3.10975696
10Urinary bladder sphincter dysfunction (HP:0002839)3.10937643
11Stenosis of the external auditory canal (HP:0000402)3.00979156
12Bilateral microphthalmos (HP:0007633)2.77162472
13Selective tooth agenesis (HP:0001592)2.74393322
14Multiple enchondromatosis (HP:0005701)2.65624831
15Abnormal lung lobation (HP:0002101)2.64780048
16Adrenal hypoplasia (HP:0000835)2.56830264
17Anophthalmia (HP:0000528)2.56679575
18Abnormality of methionine metabolism (HP:0010901)2.46222780
19Aplasia/Hypoplasia of the breasts (HP:0010311)2.42885052
20Chronic bronchitis (HP:0004469)2.41048432
21Spastic diplegia (HP:0001264)2.40110975
22Aplasia/Hypoplasia of the spleen (HP:0010451)2.39767511
23Gonadotropin excess (HP:0000837)2.38204380
24Scrotal hypoplasia (HP:0000046)2.37012799
25Conjugated hyperbilirubinemia (HP:0002908)2.34065875
26Large eyes (HP:0001090)2.33865893
27Breast aplasia (HP:0100783)2.32766719
28Esophageal atresia (HP:0002032)2.32231202
29Urinary urgency (HP:0000012)2.19149941
30Lipid accumulation in hepatocytes (HP:0006561)2.17874365
31Hyperglycinuria (HP:0003108)2.17425191
32Macroorchidism (HP:0000053)2.15272400
33Increased hepatocellular lipid droplets (HP:0006565)2.11066495
34High anterior hairline (HP:0009890)2.08209604
35Protruding tongue (HP:0010808)2.07072717
36Reticulocytopenia (HP:0001896)2.05631561
37Abnormality of serine family amino acid metabolism (HP:0010894)2.05224291
38Abnormality of glycine metabolism (HP:0010895)2.05224291
39Limb dystonia (HP:0002451)2.03230935
40Maternal diabetes (HP:0009800)2.01239338
41Colon cancer (HP:0003003)1.99610692
42Asplenia (HP:0001746)1.99259332
43Abnormal respiratory motile cilium morphology (HP:0005938)1.98920909
44Abnormal respiratory epithelium morphology (HP:0012253)1.98920909
45Chromsome breakage (HP:0040012)1.98238438
46Macrocytic anemia (HP:0001972)1.97699457
47Abnormality of the nasal septum (HP:0000419)1.97205050
48Long foot (HP:0001833)1.96304440
49Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96288582
50Hyperglycinemia (HP:0002154)1.95115384
51Chronic otitis media (HP:0000389)1.93915530
52Horseshoe kidney (HP:0000085)1.93891032
53Cortical dysplasia (HP:0002539)1.93848092
54Osteomalacia (HP:0002749)1.91831042
55Absent septum pellucidum (HP:0001331)1.89428814
56Submucous cleft hard palate (HP:0000176)1.88865999
57Impaired vibration sensation in the lower limbs (HP:0002166)1.88567078
58Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88158685
59Abnormality of serum amino acid levels (HP:0003112)1.85022179
60Microretrognathia (HP:0000308)1.84901548
61Generalized hypotonia (HP:0001290)1.84000753
62Dysphonia (HP:0001618)1.83059067
63Abnormality of cells of the erythroid lineage (HP:0012130)1.81675659
64Optic nerve coloboma (HP:0000588)1.80369093
65Bifid uvula (HP:0000193)1.79770329
66Small intestinal stenosis (HP:0012848)1.78388797
67Duodenal stenosis (HP:0100867)1.78388797
68Biliary tract neoplasm (HP:0100574)1.76191760
69Neoplasm of the liver (HP:0002896)1.75685063
70Meckel diverticulum (HP:0002245)1.75682037
71Patent foramen ovale (HP:0001655)1.73983221
72Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73479693
73Sclerocornea (HP:0000647)1.72351769
74Proximal placement of thumb (HP:0009623)1.72186725
75Drooling (HP:0002307)1.72020448
76Abnormality of the duodenum (HP:0002246)1.71854481
77Hyperphosphatemia (HP:0002905)1.71492955
78Fused cervical vertebrae (HP:0002949)1.71222163
79Holoprosencephaly (HP:0001360)1.70915707
80Optic nerve hypoplasia (HP:0000609)1.70601505
81Patellar aplasia (HP:0006443)1.69484998
82Abnormality of the septum pellucidum (HP:0007375)1.67981879
83Hepatoblastoma (HP:0002884)1.67943720
84Megaloblastic anemia (HP:0001889)1.66860793
85Restlessness (HP:0000711)1.66066380
86Homocystinuria (HP:0002156)1.65320071
87Abnormality of homocysteine metabolism (HP:0010919)1.65320071
88Uterine neoplasm (HP:0010784)1.64261653
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63419691
90Deviation of the thumb (HP:0009603)1.63127470
91Ependymoma (HP:0002888)1.62422750
92Lissencephaly (HP:0001339)1.62283478
93Abnormality of the incisor (HP:0000676)1.62254664
94Broad alveolar ridges (HP:0000187)1.62193185
95Prolonged partial thromboplastin time (HP:0003645)1.61734713
96Nephroblastoma (Wilms tumor) (HP:0002667)1.61458302
97Abnormality of sulfur amino acid metabolism (HP:0004339)1.61402558
98Abnormality of abdominal situs (HP:0011620)1.60967781
99Abdominal situs inversus (HP:0003363)1.60967781
100Abnormal number of erythroid precursors (HP:0012131)1.60089352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PTK64.73164654
2EPHA23.84893256
3TNIK3.79377260
4MST1R3.57384666
5BUB13.21392908
6CASK2.76353598
7CDC72.73425304
8TAOK12.52372592
9TTK2.43377113
10MST42.40703093
11PLK42.23224986
12MKNK22.01553617
13PBK1.96887591
14SIK11.87729467
15LMTK21.87374408
16VRK21.78691051
17TAF11.67883992
18MET1.60416391
19STK38L1.58003627
20TSSK61.56489401
21PNCK1.55373287
22PLK31.54494681
23MKNK11.51113477
24NUAK11.46720416
25INSRR1.44306218
26PLK11.39320059
27SMG11.36693416
28DYRK31.35034620
29DYRK21.34901966
30ICK1.30343414
31IRAK11.29332292
32WEE11.28376076
33DMPK1.27325280
34PRKCI1.23737178
35ZAK1.19598169
36CHEK21.19494938
37PAK41.16985467
38LATS21.12773601
39CDK191.09867449
40MAP3K101.08465464
41WNK41.05617646
42NME11.02694658
43MARK21.00925232
44STK391.00273234
45SRPK10.98854808
46BRSK20.95714127
47STK240.94958763
48ERBB40.94932569
49NEK10.91086231
50ALK0.90671595
51EIF2AK10.88879426
52PRKCG0.86377523
53CAMK1D0.85551377
54FGFR10.83744974
55STK30.81700210
56AURKB0.80944147
57CAMK1G0.76670746
58NEK20.74277241
59ATR0.73965927
60VRK10.67941426
61CHEK10.67210818
62CDK70.67187577
63EIF2AK20.65725883
64CSNK1E0.63396920
65PRKD20.63168257
66CSNK1G20.62390423
67NME20.61422217
68AURKA0.60447030
69BRSK10.60399424
70RPS6KA40.59562922
71MINK10.58269072
72MAP3K80.55923908
73TRIM280.54586379
74ATM0.53202028
75PASK0.51328909
76CDK10.48942696
77EPHB20.48924115
78PRKDC0.44869919
79PTK20.44516059
80WNK30.44424101
81LATS10.42206748
82PRKCH0.41863043
83CDK20.39161713
84OXSR10.37945906
85CSNK2A20.37759885
86CDK80.37512902
87BMX0.36168952
88STK160.35513753
89STK100.34539307
90PRKCE0.34266122
91DAPK10.33962892
92LIMK10.33386936
93ROCK20.31439705
94STK40.30348436
95DYRK1B0.30239695
96CSNK1G10.30151240
97ROCK10.29226098
98RPS6KB20.28838032
99CSNK2A10.26963743
100DYRK1A0.26869362

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.87794937
2DNA replication_Homo sapiens_hsa030302.75822065
3Steroid biosynthesis_Homo sapiens_hsa001002.71861634
4Mismatch repair_Homo sapiens_hsa034302.45257468
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37723899
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32496052
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29034483
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.15586124
9Non-homologous end-joining_Homo sapiens_hsa034502.12484435
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99809987
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96143502
12Selenocompound metabolism_Homo sapiens_hsa004501.92587465
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86940093
14One carbon pool by folate_Homo sapiens_hsa006701.80647556
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79290045
16Ribosome_Homo sapiens_hsa030101.78354937
17RNA transport_Homo sapiens_hsa030131.73374438
18Cell cycle_Homo sapiens_hsa041101.71089107
19Spliceosome_Homo sapiens_hsa030401.66924743
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62478140
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.58169315
22Retinol metabolism_Homo sapiens_hsa008301.57517600
23Proteasome_Homo sapiens_hsa030501.53166170
24beta-Alanine metabolism_Homo sapiens_hsa004101.52360301
25Caffeine metabolism_Homo sapiens_hsa002321.49874617
26Vitamin B6 metabolism_Homo sapiens_hsa007501.43365028
27Basal cell carcinoma_Homo sapiens_hsa052171.39903964
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34310441
29Base excision repair_Homo sapiens_hsa034101.34113446
30Homologous recombination_Homo sapiens_hsa034401.32572456
31Pyruvate metabolism_Homo sapiens_hsa006201.32497314
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31917429
33Starch and sucrose metabolism_Homo sapiens_hsa005001.30782262
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29440287
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29047034
36Pyrimidine metabolism_Homo sapiens_hsa002401.28840432
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27860144
38Biosynthesis of amino acids_Homo sapiens_hsa012301.16529069
39Basal transcription factors_Homo sapiens_hsa030221.15521039
40mRNA surveillance pathway_Homo sapiens_hsa030151.09782217
41Hippo signaling pathway_Homo sapiens_hsa043901.09116110
42Fatty acid degradation_Homo sapiens_hsa000711.09023821
43Nucleotide excision repair_Homo sapiens_hsa034201.07318296
44RNA degradation_Homo sapiens_hsa030181.06770912
45Arginine and proline metabolism_Homo sapiens_hsa003301.06155840
46Phenylalanine metabolism_Homo sapiens_hsa003601.05626556
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05290615
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.03237808
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.00648109
50Chemical carcinogenesis_Homo sapiens_hsa052041.00562797
51Fanconi anemia pathway_Homo sapiens_hsa034600.99023607
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94548827
53Arginine biosynthesis_Homo sapiens_hsa002200.93561613
54Histidine metabolism_Homo sapiens_hsa003400.89853558
55Wnt signaling pathway_Homo sapiens_hsa043100.88325481
56Linoleic acid metabolism_Homo sapiens_hsa005910.87292718
57Tyrosine metabolism_Homo sapiens_hsa003500.86035120
58Vitamin digestion and absorption_Homo sapiens_hsa049770.86003749
59Tight junction_Homo sapiens_hsa045300.83122090
60Tryptophan metabolism_Homo sapiens_hsa003800.82956569
61Huntingtons disease_Homo sapiens_hsa050160.82025761
62Fatty acid biosynthesis_Homo sapiens_hsa000610.81696511
63Parkinsons disease_Homo sapiens_hsa050120.81030615
64Adherens junction_Homo sapiens_hsa045200.78951672
65Propanoate metabolism_Homo sapiens_hsa006400.78859596
66Protein export_Homo sapiens_hsa030600.78162226
67Bile secretion_Homo sapiens_hsa049760.77350835
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76577696
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75630410
70Purine metabolism_Homo sapiens_hsa002300.75352798
71Thyroid cancer_Homo sapiens_hsa052160.74353893
72Butanoate metabolism_Homo sapiens_hsa006500.71920385
73Lysine degradation_Homo sapiens_hsa003100.70158249
74Carbon metabolism_Homo sapiens_hsa012000.69711743
75Fat digestion and absorption_Homo sapiens_hsa049750.69434513
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69093852
77Glutathione metabolism_Homo sapiens_hsa004800.67223495
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66103791
79Axon guidance_Homo sapiens_hsa043600.65999933
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64667319
81Cardiac muscle contraction_Homo sapiens_hsa042600.59530688
82Folate biosynthesis_Homo sapiens_hsa007900.59233959
83Metabolic pathways_Homo sapiens_hsa011000.59168373
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59116609
85Hedgehog signaling pathway_Homo sapiens_hsa043400.58115552
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57958049
87Peroxisome_Homo sapiens_hsa041460.56144892
88Oxidative phosphorylation_Homo sapiens_hsa001900.55527357
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51407761
90p53 signaling pathway_Homo sapiens_hsa041150.50410121
91Fatty acid metabolism_Homo sapiens_hsa012120.49323150
92Ether lipid metabolism_Homo sapiens_hsa005650.46602131
93Thyroid hormone synthesis_Homo sapiens_hsa049180.46499251
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45149088
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44655615
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42306884
97Nicotine addiction_Homo sapiens_hsa050330.37147576
98Colorectal cancer_Homo sapiens_hsa052100.32612428
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30646864
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30406749

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