FGF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.54011911
2cardiac myofibril assembly (GO:0055003)8.42485714
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.68862903
4myofibril assembly (GO:0030239)7.19779397
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.13084981
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.03213164
7negative regulation of potassium ion transmembrane transport (GO:1901380)7.00570086
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.67288871
9tricarboxylic acid cycle (GO:0006099)6.66736061
10endothelium development (GO:0003158)6.65450304
11cardiac muscle contraction (GO:0060048)6.51032166
12aggressive behavior (GO:0002118)6.32472670
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.32284286
14regulation of relaxation of muscle (GO:1901077)6.07489418
15regulation of actin filament-based movement (GO:1903115)6.02325975
16cardiac muscle cell development (GO:0055013)6.00301823
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.89159272
18ventricular cardiac muscle cell action potential (GO:0086005)5.71140211
19plasma membrane repair (GO:0001778)5.69962431
20cardiac cell development (GO:0055006)5.63799143
21epithelial cell differentiation involved in kidney development (GO:0035850)5.48795273
22regulation of female receptivity (GO:0045924)5.48513862
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.45727248
24actin-myosin filament sliding (GO:0033275)5.42289526
25muscle filament sliding (GO:0030049)5.42289526
26actomyosin structure organization (GO:0031032)5.31652930
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.31027658
28angiogenesis involved in wound healing (GO:0060055)5.25476325
29regulation of cell communication by electrical coupling (GO:0010649)5.23768140
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.20051643
31cardiac muscle tissue morphogenesis (GO:0055008)5.15821420
32heart trabecula formation (GO:0060347)5.15750568
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.14462822
34carnitine shuttle (GO:0006853)5.07319011
35regulation of acyl-CoA biosynthetic process (GO:0050812)5.05481189
36adult heart development (GO:0007512)5.03231839
37cardiac muscle hypertrophy (GO:0003300)5.02483715
38regulation of sarcomere organization (GO:0060297)5.02250219
39regulation of skeletal muscle contraction (GO:0014819)5.01157381
40seminiferous tubule development (GO:0072520)4.99158026
41cell communication involved in cardiac conduction (GO:0086065)4.94891699
42striated muscle hypertrophy (GO:0014897)4.86620741
43phosphatidylinositol acyl-chain remodeling (GO:0036149)4.81026832
44female mating behavior (GO:0060180)4.79823484
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.77914423
46regulation of striated muscle contraction (GO:0006942)4.77664314
47regulation of glucokinase activity (GO:0033131)4.75070722
48regulation of hexokinase activity (GO:1903299)4.75070722
49striated muscle contraction (GO:0006941)4.68977502
50heart process (GO:0003015)4.64503308
51heart contraction (GO:0060047)4.64503308
52regulation of membrane repolarization (GO:0060306)4.63507532
53muscle tissue morphogenesis (GO:0060415)4.60291088
54sarcoplasmic reticulum calcium ion transport (GO:0070296)4.58783822
55regulation of coenzyme metabolic process (GO:0051196)4.58218101
56regulation of cofactor metabolic process (GO:0051193)4.58218101
57regulation of the force of heart contraction (GO:0002026)4.54890488
58regulation of cardiac muscle cell contraction (GO:0086004)4.54361025
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52847298
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.49446194
61actin-mediated cell contraction (GO:0070252)4.49425389
62fatty acid transmembrane transport (GO:1902001)4.40774603
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34129069
64positive regulation of B cell differentiation (GO:0045579)4.28793017
65negative regulation of JAK-STAT cascade (GO:0046426)4.28237779
66regulation of cardiac muscle contraction (GO:0055117)4.27811330
67NADH metabolic process (GO:0006734)4.27224218
68muscle hypertrophy (GO:0014896)4.27195759
69response to interferon-beta (GO:0035456)4.22403614
70relaxation of cardiac muscle (GO:0055119)4.19766164
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.18896011
72glomerular filtration (GO:0003094)4.18360368
73respiratory electron transport chain (GO:0022904)4.17039802
74grooming behavior (GO:0007625)4.16478489
75ATP synthesis coupled proton transport (GO:0015986)4.13116086
76energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13116086
77cell communication by electrical coupling (GO:0010644)4.12754898
78electron transport chain (GO:0022900)4.05047361
79cardiac muscle cell action potential involved in contraction (GO:0086002)4.04124382
80cardiac muscle cell action potential (GO:0086001)4.02184235
81negative regulation of potassium ion transport (GO:0043267)4.01960801
82regulation of heart rate (GO:0002027)4.01745201
83positive regulation of vasculogenesis (GO:2001214)3.98970158
84hyperosmotic salinity response (GO:0042538)3.96599733
85regulation of sequestering of triglyceride (GO:0010889)3.93523744
86oxygen transport (GO:0015671)3.91219045
87oxidative phosphorylation (GO:0006119)3.90964373
88positive regulation of odontogenesis (GO:0042482)3.87751242
892-oxoglutarate metabolic process (GO:0006103)3.84527769
90cardiac conduction (GO:0061337)3.77782856
91creatine metabolic process (GO:0006600)3.76829061
92regulation of heart contraction (GO:0008016)3.76156531
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.75702183
94regulation of sulfur metabolic process (GO:0042762)3.75652789
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.73935652
96cell differentiation involved in metanephros development (GO:0072202)3.71191808
97mucosal-associated lymphoid tissue development (GO:0048537)3.70610917
98Peyers patch development (GO:0048541)3.70610917
99regulation of germinal center formation (GO:0002634)3.69986254
100carnitine transmembrane transport (GO:1902603)3.67938377
101negative regulation of B cell apoptotic process (GO:0002903)3.67234328
102regulation of cardioblast differentiation (GO:0051890)3.67187665
103thrombin receptor signaling pathway (GO:0070493)3.63965422
104positive regulation of cation channel activity (GO:2001259)3.62668976
105endothelial cell proliferation (GO:0001935)3.61191544
106detection of calcium ion (GO:0005513)3.58733363
107regulation of calcium ion transmembrane transporter activity (GO:1901019)3.58098731
108regulation of calcium ion transmembrane transport (GO:1903169)3.58098731
109regulation of heart rate by cardiac conduction (GO:0086091)3.58078698
110regulation of ATPase activity (GO:0043462)3.57660002
111regulation of ATP catabolic process (GO:1903289)3.57660002
112ventricular cardiac muscle cell development (GO:0055015)3.55985672
113chaperone mediated protein folding requiring cofactor (GO:0051085)3.55820871
114positive regulation of heart contraction (GO:0045823)3.53580126
115natural killer cell mediated cytotoxicity (GO:0042267)3.53102254
116natural killer cell mediated immunity (GO:0002228)3.53102254
117positive regulation of heart rate (GO:0010460)3.52897188
118negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.52840147
119negative regulation of cytosolic calcium ion concentration (GO:0051481)3.52469476
120renal filtration (GO:0097205)3.52235770
121cardiac muscle adaptation (GO:0014887)3.51443174
122cardiac muscle hypertrophy in response to stress (GO:0014898)3.51443174
123muscle hypertrophy in response to stress (GO:0003299)3.51443174
124positive regulation of transforming growth factor beta production (GO:0071636)3.50979380
125ubiquinone biosynthetic process (GO:0006744)3.46526617
126negative regulation of nitric oxide biosynthetic process (GO:0045019)3.43862549
127regulation of fatty acid oxidation (GO:0046320)3.41776987
128actin filament-based movement (GO:0030048)3.39466691
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39340275
130negative regulation of protein localization to cell surface (GO:2000009)3.39297398
131autophagic vacuole fusion (GO:0000046)3.38281340
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.37578808
133trabecula formation (GO:0060343)3.36500353
134mismatch repair (GO:0006298)3.35926968
135somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35602980
136somatic hypermutation of immunoglobulin genes (GO:0016446)3.35602980
137amino-acid betaine transport (GO:0015838)3.33339573
138carnitine transport (GO:0015879)3.33339573
139aspartate family amino acid catabolic process (GO:0009068)3.33252337
140negative regulation of striated muscle cell apoptotic process (GO:0010664)3.32548595
141branched-chain amino acid catabolic process (GO:0009083)3.28001283
142mature B cell differentiation involved in immune response (GO:0002313)3.27507888
143regulation of B cell apoptotic process (GO:0002902)3.21741222
144ribosomal small subunit assembly (GO:0000028)3.20797929
145hematopoietic stem cell proliferation (GO:0071425)3.20110347
146heparin metabolic process (GO:0030202)3.18951180
147heparin biosynthetic process (GO:0030210)3.18951180
148regulation of histone phosphorylation (GO:0033127)3.18108551
149dopamine transport (GO:0015872)3.16754713
150negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.16390216
151adenosine metabolic process (GO:0046085)3.14140795
152negative regulation of cell cycle G2/M phase transition (GO:1902750)3.07409859
153regulation of helicase activity (GO:0051095)3.06384658
154deoxyribonucleotide catabolic process (GO:0009264)3.05265223
155branched-chain amino acid metabolic process (GO:0009081)3.04044799
156GTP biosynthetic process (GO:0006183)2.98481436
157parental behavior (GO:0060746)2.98410509
158arginine catabolic process (GO:0006527)2.98377068
159regulation of respiratory burst (GO:0060263)2.98352935
160tyrosine phosphorylation of STAT protein (GO:0007260)2.93102748
161deoxyribose phosphate catabolic process (GO:0046386)2.92878358
162regulation of thymocyte apoptotic process (GO:0070243)2.91836081
163ubiquinone metabolic process (GO:0006743)2.90397039
164phosphatidylserine acyl-chain remodeling (GO:0036150)2.88035070
165pyrimidine nucleotide catabolic process (GO:0006244)2.87490526
166regulation of transmission of nerve impulse (GO:0051969)2.87471863
167regulation of hydrogen peroxide metabolic process (GO:0010310)2.87385703
168DNA deamination (GO:0045006)2.86868862
169rRNA modification (GO:0000154)2.82821837
170maternal behavior (GO:0042711)2.82272387
171preassembly of GPI anchor in ER membrane (GO:0016254)2.82258983
172positive regulation of antigen processing and presentation (GO:0002579)2.80814757
173definitive hemopoiesis (GO:0060216)2.79021252
174regulation of telomerase activity (GO:0051972)2.78047364
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77843362
176response to vitamin E (GO:0033197)2.77167158
177UTP biosynthetic process (GO:0006228)2.75279255
178nuclear envelope reassembly (GO:0031468)2.74499884
179mitotic nuclear envelope reassembly (GO:0007084)2.74499884
180ventricular system development (GO:0021591)2.74290844
181pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73185881
182regulation of vasculogenesis (GO:2001212)2.69719337
183purine deoxyribonucleotide catabolic process (GO:0009155)2.69217389
184amino acid salvage (GO:0043102)2.68498708
185L-methionine salvage (GO:0071267)2.68498708
186L-methionine biosynthetic process (GO:0071265)2.68498708
187regulation of B cell differentiation (GO:0045577)2.68482284
188UTP metabolic process (GO:0046051)2.68359245
189negative regulation of telomere maintenance (GO:0032205)2.67134058
190negative regulation of granulocyte differentiation (GO:0030853)2.65216865
191activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.65210557
192platelet dense granule organization (GO:0060155)2.64324428
193positive regulation of megakaryocyte differentiation (GO:0045654)2.64233221
194negative regulation of translational initiation (GO:0045947)2.64007378
195histamine secretion (GO:0001821)2.63378961
196DNA double-strand break processing (GO:0000729)2.61911644
197sleep (GO:0030431)2.59801621
198base-excision repair, AP site formation (GO:0006285)2.58034767
199quinone biosynthetic process (GO:1901663)2.57837961
200behavioral response to ethanol (GO:0048149)2.56752817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse9.78318181
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10000884
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.76388738
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.40060063
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.94176618
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.75790397
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.74085434
8TBX20_22328084_ChIP-Seq_HEART_Mouse3.74085434
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.52859220
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47215435
11ZNF263_19887448_ChIP-Seq_K562_Human3.31016245
12EZH2_22144423_ChIP-Seq_EOC_Human3.11210775
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.95782796
14E2F7_22180533_ChIP-Seq_HELA_Human2.90890547
15GATA1_22025678_ChIP-Seq_K562_Human2.70767257
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66589531
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.64702875
18MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.64659135
19IRF1_19129219_ChIP-ChIP_H3396_Human2.55018138
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35326124
21SCL_19346495_ChIP-Seq_HPC-7_Human2.35019404
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32626605
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20023263
24IGF1R_20145208_ChIP-Seq_DFB_Human2.10464457
25GATA4_21415370_ChIP-Seq_HL-1_Mouse2.08957656
26MYC_18940864_ChIP-ChIP_HL60_Human2.08542016
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07491272
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05537893
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99434094
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.97482997
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94635276
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94333023
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93916188
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93747000
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92650497
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.90543370
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85807193
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84043413
39CLOCK_20551151_ChIP-Seq_293T_Human1.83711362
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78437954
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.78305128
42VDR_23849224_ChIP-Seq_CD4+_Human1.77087534
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75399083
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73381005
45FUS_26573619_Chip-Seq_HEK293_Human1.71319760
46FOXP3_21729870_ChIP-Seq_TREG_Human1.66059993
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63391573
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63318405
49DROSHA_22980978_ChIP-Seq_HELA_Human1.62412071
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.61723822
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.60371672
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.59771518
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.59062903
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.58685808
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57415665
56CIITA_25753668_ChIP-Seq_RAJI_Human1.55734331
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.54186691
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54048676
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53572990
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.53385294
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51534780
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49492346
63EWS_26573619_Chip-Seq_HEK293_Human1.48918301
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44400210
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44196099
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40618287
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36034560
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35186471
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34270926
70TP53_22573176_ChIP-Seq_HFKS_Human1.34071482
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31857460
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31399116
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30266395
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30077676
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29131204
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28224269
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27741332
78ELK1_19687146_ChIP-ChIP_HELA_Human1.24591441
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24342215
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23838765
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23622485
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.23622485
83P300_27268052_Chip-Seq_Bcells_Human1.23616835
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23216469
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23138945
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22868506
87MYB_26560356_Chip-Seq_TH2_Human1.22309615
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21567980
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21268762
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.20883244
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19963862
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.19129544
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17819732
94KDM2B_26808549_Chip-Seq_DND41_Human1.17733548
95SPI1_23547873_ChIP-Seq_NB4_Human1.16498277
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16339651
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15051687
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14052200
99* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13699606
100* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13699606
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13685631
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13323716
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13179983
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.13020908
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11300033
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.10790878
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10503584
108BCL6_27268052_Chip-Seq_Bcells_Human1.09393589
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09350707
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08377984
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08198656
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08095814
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07960625
114CTCF_27219007_Chip-Seq_Bcells_Human1.07857896
115* ISL1_27105846_Chip-Seq_CPCs_Mouse1.07493861
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06111019
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05094488
118* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04917068
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.02042550
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.01928487
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.01403458
122ERG_20517297_ChIP-Seq_VCAP_Human1.00951233
123* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00631556
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00284763
125TP63_22573176_ChIP-Seq_HFKS_Human0.99890851
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99849048
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99416632
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99165264
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99160578
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98502851
131RUNX_20019798_ChIP-Seq_JUKART_Human0.98203211
132GATA3_26560356_Chip-Seq_TH2_Human0.98033763
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97927369
134NANOG_20526341_ChIP-Seq_ESCs_Human0.97427897
135BCAT_22108803_ChIP-Seq_LS180_Human0.97281403
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96865555
137RARB_27405468_Chip-Seq_BRAIN_Mouse0.96789027
138EGR1_19374776_ChIP-ChIP_THP-1_Human0.96691583
139CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95992466
140ZNF274_21170338_ChIP-Seq_K562_Hela0.95961049
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95847417
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95801819
143CJUN_26792858_Chip-Seq_BT549_Human0.95764813
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95707773
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95433786
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.95253895
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95246755
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94835161
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94703342
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92871848
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.92867512
152RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92802024
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92710138
154ATF3_27146783_Chip-Seq_COLON_Human0.92591732
155GATA1_19941826_ChIP-Seq_K562_Human0.92417777
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92195926
157RAC3_21632823_ChIP-Seq_H3396_Human0.91639953
158LXR_22292898_ChIP-Seq_THP-1_Human0.91473668
159NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90964912
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90964912
161* EZH2_27304074_Chip-Seq_ESCs_Mouse0.90926305
162LXR_22158963_ChIP-Seq_LIVER_Mouse0.90922144
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.89500795
164TAF2_19829295_ChIP-Seq_ESCs_Human0.89056579
165SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88472190
166FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88078713
167* EZH2_27294783_Chip-Seq_ESCs_Mouse0.87942531
168RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87942105
169TTF2_22483619_ChIP-Seq_HELA_Human0.87869363
170KDM2B_26808549_Chip-Seq_K562_Human0.86938073
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86889772
172KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86553707
173DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86449855
174RACK7_27058665_Chip-Seq_MCF-7_Human0.86397328
175VDR_22108803_ChIP-Seq_LS180_Human0.86362076
176SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86040419
177PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85814066
178GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85301388
179GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85061871
180TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84698722
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84393308
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.83262172
183TP53_23651856_ChIP-Seq_MEFs_Mouse0.82814189
184SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82267805
185STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81673815
186TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80982129
187FOXA2_19822575_ChIP-Seq_HepG2_Human0.80800382
188UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80661220
189SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79750403
190* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79334034
191GATA2_19941826_ChIP-Seq_K562_Human0.78399815
192PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76167700
193GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76095258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.07124844
2MP0003646_muscle_fatigue5.80393200
3MP0004084_abnormal_cardiac_muscle5.65734311
4MP0000751_myopathy5.24940224
5MP0004215_abnormal_myocardial_fiber4.96147258
6MP0002132_abnormal_respiratory_system4.49447108
7MP0002138_abnormal_hepatobiliary_system4.14705646
8MP0004036_abnormal_muscle_relaxation4.09285117
9MP0005330_cardiomyopathy3.82576987
10MP0005084_abnormal_gallbladder_morpholo3.41770252
11MP0005464_abnormal_platelet_physiology3.40887072
12MP0000749_muscle_degeneration3.38957872
13MP0009278_abnormal_bone_marrow3.12022527
14MP0002972_abnormal_cardiac_muscle3.11658247
15MP0005645_abnormal_hypothalamus_physiol3.09591475
16MP0009697_abnormal_copulation3.02753165
17MP0004087_abnormal_muscle_fiber2.97358779
18MP0003137_abnormal_impulse_conducting2.95562596
19MP0008775_abnormal_heart_ventricle2.93496654
20MP0004484_altered_response_of2.77544909
21MP0000750_abnormal_muscle_regeneration2.76935793
22MP0006054_spinal_hemorrhage2.67223270
23MP0004130_abnormal_muscle_cell2.61669590
24* MP0001544_abnormal_cardiovascular_syste2.60062899
25* MP0005385_cardiovascular_system_phenoty2.60062899
26MP0005620_abnormal_muscle_contractility2.56037828
27MP0006138_congestive_heart_failure2.51612691
28MP0003436_decreased_susceptibility_to2.50012314
29* MP0010630_abnormal_cardiac_muscle2.49422112
30* MP0002106_abnormal_muscle_physiology2.27756374
31MP0000465_gastrointestinal_hemorrhage2.22613851
32MP0001968_abnormal_touch/_nociception2.21854659
33MP0004085_abnormal_heartbeat2.20917112
34MP0003828_pulmonary_edema2.19591269
35MP0002269_muscular_atrophy2.12102429
36MP0004510_myositis2.11237142
37MP0000678_abnormal_parathyroid_gland2.06959500
38MP0000569_abnormal_digit_pigmentation1.99231404
39MP0005646_abnormal_pituitary_gland1.92380787
40MP0003221_abnormal_cardiomyocyte_apopto1.90952752
41MP0000613_abnormal_salivary_gland1.88935059
42* MP0005369_muscle_phenotype1.86799257
43MP0004145_abnormal_muscle_electrophysio1.85501150
44MP0008007_abnormal_cellular_replicative1.83055742
45MP0000759_abnormal_skeletal_muscle1.82912199
46MP0000747_muscle_weakness1.76634485
47MP0005075_abnormal_melanosome_morpholog1.72916001
48MP0000467_abnormal_esophagus_morphology1.70851506
49MP0009053_abnormal_anal_canal1.69566102
50MP0006036_abnormal_mitochondrial_physio1.67002410
51MP0001764_abnormal_homeostasis1.64572943
52MP0002009_preneoplasia1.64214788
53MP0002653_abnormal_ependyma_morphology1.61616002
54MP0004233_abnormal_muscle_weight1.59762454
55MP0010030_abnormal_orbit_morphology1.58806532
56MP0002127_abnormal_cardiovascular_syste1.54147990
57MP0003252_abnormal_bile_duct1.51544852
58MP0005666_abnormal_adipose_tissue1.49850386
59MP0008058_abnormal_DNA_repair1.47036707
60MP0002396_abnormal_hematopoietic_system1.40120916
61MP0002332_abnormal_exercise_endurance1.37794967
62MP0003950_abnormal_plasma_membrane1.34381488
63MP0000343_altered_response_to1.32941027
64MP0002234_abnormal_pharynx_morphology1.32565724
65MP0001835_abnormal_antigen_presentation1.27815101
66MP0003279_aneurysm1.27255074
67MP0008438_abnormal_cutaneous_collagen1.25741836
68MP0005165_increased_susceptibility_to1.25529167
69MP0003724_increased_susceptibility_to1.24046682
70MP0002735_abnormal_chemical_nociception1.23754026
71MP0006276_abnormal_autonomic_nervous1.23545533
72MP0004808_abnormal_hematopoietic_stem1.21278464
73MP0003075_altered_response_to1.20097022
74MP0008004_abnormal_stomach_pH1.15718315
75MP0010368_abnormal_lymphatic_system1.15549459
76MP0001664_abnormal_digestion1.15361420
77MP0002148_abnormal_hypersensitivity_rea1.13187954
78MP0003638_abnormal_response/metabolism_1.12531643
79MP0005220_abnormal_exocrine_pancreas1.12288021
80* MP0000266_abnormal_heart_morphology1.12072702
81MP0004185_abnormal_adipocyte_glucose1.10966064
82MP0005670_abnormal_white_adipose1.10790611
83MP0009764_decreased_sensitivity_to1.09203230
84MP0001545_abnormal_hematopoietic_system1.07499257
85MP0005397_hematopoietic_system_phenotyp1.07499257
86MP0005623_abnormal_meninges_morphology1.05778285
87MP0005367_renal/urinary_system_phenotyp1.03894922
88MP0000516_abnormal_urinary_system1.03894922
89MP0003186_abnormal_redox_activity1.03435377
90MP0004858_abnormal_nervous_system1.01483838
91MP0000470_abnormal_stomach_morphology1.01122133
92MP0002102_abnormal_ear_morphology1.01042730
93MP0005375_adipose_tissue_phenotype1.00693381
94MP0003283_abnormal_digestive_organ0.98851242
95MP0003303_peritoneal_inflammation0.97219540
96MP0005410_abnormal_fertilization0.95936312
97MP0005275_abnormal_skin_tensile0.95897072
98MP0003705_abnormal_hypodermis_morpholog0.95142191
99MP0003718_maternal_effect0.94776802
100MP0001905_abnormal_dopamine_level0.93033529
101MP0002108_abnormal_muscle_morphology0.92706537
102MP0005000_abnormal_immune_tolerance0.91428628
103MP0002282_abnormal_trachea_morphology0.90842207
104MP0003866_abnormal_defecation0.90323809
105MP0006035_abnormal_mitochondrial_morpho0.89837367
106MP0002928_abnormal_bile_duct0.88571944
107MP0005390_skeleton_phenotype0.83133214
108MP0010094_abnormal_chromosome_stability0.82922094
109MP0000685_abnormal_immune_system0.81990185
110MP0000230_abnormal_systemic_arterial0.81363110
111MP0008872_abnormal_physiological_respon0.78990784
112* MP0002128_abnormal_blood_circulation0.78444740
113MP0004133_heterotaxia0.78204606
114MP0002909_abnormal_adrenal_gland0.78185202
115MP0003566_abnormal_cell_adhesion0.78109287
116* MP0003567_abnormal_fetal_cardiomyocyte0.76327536
117MP0002019_abnormal_tumor_incidence0.75635998
118MP0001293_anophthalmia0.75234018
119MP0001533_abnormal_skeleton_physiology0.73407517
120MP0000689_abnormal_spleen_morphology0.73268958
121MP0002166_altered_tumor_susceptibility0.73236826
122MP0002933_joint_inflammation0.73024974
123MP0006292_abnormal_olfactory_placode0.72934120
124MP0002160_abnormal_reproductive_system0.72465423
125MP0005187_abnormal_penis_morphology0.72200364
126MP0003183_abnormal_peptide_metabolism0.71235152
127MP0002822_catalepsy0.71157525
128MP0005266_abnormal_metabolism0.70974762
129MP0006072_abnormal_retinal_apoptosis0.67667058
130MP0001881_abnormal_mammary_gland0.66438078
131MP0003119_abnormal_digestive_system0.66341493
132MP0008873_increased_physiological_sensi0.65760231
133MP0002398_abnormal_bone_marrow0.64643888
134MP0005503_abnormal_tendon_morphology0.64275625
135MP0003943_abnormal_hepatobiliary_system0.64026936
136MP0002932_abnormal_joint_morphology0.63844901
137MP0000767_abnormal_smooth_muscle0.63570800
138MP0000733_abnormal_muscle_development0.63428905
139MP0000013_abnormal_adipose_tissue0.63188627
140MP0003693_abnormal_embryo_hatching0.62481811
141MP0003315_abnormal_perineum_morphology0.62033461
142MP0004272_abnormal_basement_membrane0.60914886
143MP0000003_abnormal_adipose_tissue0.60295842
144MP0001879_abnormal_lymphatic_vessel0.57811177
145MP0004043_abnormal_pH_regulation0.55908638
146MP0004924_abnormal_behavior0.49329466
147MP0005386_behavior/neurological_phenoty0.49329466
148MP0002971_abnormal_brown_adipose0.47418764
149MP0004147_increased_porphyrin_level0.46456568
150MP0009780_abnormal_chondrocyte_physiolo0.46251672
151MP0001958_emphysema0.46069238
152MP0005535_abnormal_body_temperature0.45919071
153MP0002078_abnormal_glucose_homeostasis0.45800089
154MP0002925_abnormal_cardiovascular_devel0.45125365
155MP0009384_cardiac_valve_regurgitation0.44349720
156MP0002295_abnormal_pulmonary_circulatio0.42998899
157MP0005319_abnormal_enzyme/_coenzyme0.37962597
158MP0003045_fibrosis0.37630475
159MP0001614_abnormal_blood_vessel0.36617385
160MP0008874_decreased_physiological_sensi0.35238480
161MP0003806_abnormal_nucleotide_metabolis0.32637309
162MP0005595_abnormal_vascular_smooth0.31904821
163MP0008569_lethality_at_weaning0.30660196
164* MP0003984_embryonic_growth_retardation0.30404521
165* MP0002088_abnormal_embryonic_growth/wei0.29342734
166MP0008961_abnormal_basal_metabolism0.29310881
167MP0001853_heart_inflammation0.29097068
168MP0001784_abnormal_fluid_regulation0.28450720
169MP0002877_abnormal_melanocyte_morpholog0.27988373
170MP0001727_abnormal_embryo_implantation0.27874364
171MP0002133_abnormal_respiratory_system0.25828263
172MP0005388_respiratory_system_phenotype0.25828263
173MP0003948_abnormal_gas_homeostasis0.24686864
174MP0001529_abnormal_vocalization0.22387134
175MP0002090_abnormal_vision0.21961778
176MP0003091_abnormal_cell_migration0.21726248
177MP0005334_abnormal_fat_pad0.21592324
178MP0005167_abnormal_blood-brain_barrier0.21444186

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.11854388
2Ventricular tachycardia (HP:0004756)7.21823397
3Atrial fibrillation (HP:0005110)6.47134192
4Primary atrial arrhythmia (HP:0001692)6.07245023
5Calf muscle hypertrophy (HP:0008981)6.05515541
6Supraventricular tachycardia (HP:0004755)5.89972878
7Supraventricular arrhythmia (HP:0005115)5.78118418
8Muscle fiber splitting (HP:0003555)5.56404503
9Muscle hypertrophy of the lower extremities (HP:0008968)5.42570452
10Lipoatrophy (HP:0100578)5.35984500
11Right ventricular cardiomyopathy (HP:0011663)5.34215853
12Abnormality of the calf musculature (HP:0001430)5.16280571
13Syncope (HP:0001279)5.11657484
14Exercise-induced myalgia (HP:0003738)5.11555404
15Bundle branch block (HP:0011710)5.07231479
16Exercise-induced muscle cramps (HP:0003710)5.05084614
17Palpitations (HP:0001962)4.70384044
18Myoglobinuria (HP:0002913)4.60377974
19Hyporeflexia of lower limbs (HP:0002600)4.48641074
20Dilated cardiomyopathy (HP:0001644)4.42816126
21Subaortic stenosis (HP:0001682)4.33731064
22Abnormality of the left ventricular outflow tract (HP:0011103)4.33731064
23Prolonged QT interval (HP:0001657)4.31615495
24Type I transferrin isoform profile (HP:0003642)4.21702974
25Heart block (HP:0012722)4.14036965
26Colon cancer (HP:0003003)4.09111933
27Increased connective tissue (HP:0009025)4.07594188
28Atrioventricular block (HP:0001678)4.04989823
29Ventricular arrhythmia (HP:0004308)4.03855747
30Abnormal atrioventricular conduction (HP:0005150)3.94191239
31Ventricular fibrillation (HP:0001663)3.81816076
32Thrombocytosis (HP:0001894)3.78763843
33Hyperglycinuria (HP:0003108)3.77501963
34EMG: myopathic abnormalities (HP:0003458)3.68493365
35Asymmetric septal hypertrophy (HP:0001670)3.64140740
36Abnormality of B cell number (HP:0010975)3.63238187
37Rhabdomyolysis (HP:0003201)3.51991239
38Abnormal protein glycosylation (HP:0012346)3.47526316
39Abnormal glycosylation (HP:0012345)3.47526316
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.47526316
41Abnormal protein N-linked glycosylation (HP:0012347)3.47526316
42Abolished electroretinogram (ERG) (HP:0000550)3.44609486
43Difficulty running (HP:0009046)3.42480036
44Molar tooth sign on MRI (HP:0002419)3.28658252
45Abnormality of midbrain morphology (HP:0002418)3.28658252
46Spontaneous abortion (HP:0005268)3.28375877
47Myotonia (HP:0002486)3.25004711
48Chronic otitis media (HP:0000389)3.23458413
49Abnormal EKG (HP:0003115)3.14990413
50Hepatic necrosis (HP:0002605)3.12842978
51Abnormal mitochondria in muscle tissue (HP:0008316)3.10516281
52Elevated erythrocyte sedimentation rate (HP:0003565)3.07656686
53Acute necrotizing encephalopathy (HP:0006965)3.06972326
54Panhypogammaglobulinemia (HP:0003139)3.05025576
55Abnormality of the prostate (HP:0008775)3.01636670
56Difficulty climbing stairs (HP:0003551)3.01189879
57Left ventricular hypertrophy (HP:0001712)2.96693485
58Prolonged bleeding time (HP:0003010)2.88587618
59Ketoacidosis (HP:0001993)2.82325874
60Abnormality of glycine metabolism (HP:0010895)2.80744613
61Abnormality of serine family amino acid metabolism (HP:0010894)2.80744613
62Prostate neoplasm (HP:0100787)2.80093101
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.79940688
64Stomach cancer (HP:0012126)2.79695068
65Pustule (HP:0200039)2.77859329
66Hepatocellular necrosis (HP:0001404)2.74918388
67Rough bone trabeculation (HP:0100670)2.71005251
68Increased IgM level (HP:0003496)2.70416158
69Acute encephalopathy (HP:0006846)2.63833973
70B lymphocytopenia (HP:0010976)2.63023627
71Seborrheic dermatitis (HP:0001051)2.61947572
72Increased muscle lipid content (HP:0009058)2.61868925
73Abnormality of macular pigmentation (HP:0008002)2.60292740
74Palmoplantar keratoderma (HP:0000982)2.59191327
75Bifid tongue (HP:0010297)2.58490071
76Progressive macrocephaly (HP:0004481)2.57864335
77Increased variability in muscle fiber diameter (HP:0003557)2.57644530
78Amaurosis fugax (HP:0100576)2.57071100
79Abnormality of fatty-acid metabolism (HP:0004359)2.56412978
80Mitochondrial inheritance (HP:0001427)2.53694053
81Autoimmune hemolytic anemia (HP:0001890)2.50950351
82Testicular atrophy (HP:0000029)2.50054612
83Reduced antithrombin III activity (HP:0001976)2.49232863
84Hypoglycemic coma (HP:0001325)2.48169015
85Abnormality of the peritoneum (HP:0002585)2.44745642
86Conjunctival hamartoma (HP:0100780)2.44101824
87Epistaxis (HP:0000421)2.44030904
88Limb-girdle muscle atrophy (HP:0003797)2.43761307
89Cerebral edema (HP:0002181)2.43035576
90Dicarboxylic aciduria (HP:0003215)2.42549214
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42549214
92Pheochromocytoma (HP:0002666)2.37974871
93Increased CSF lactate (HP:0002490)2.35335985
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.35090274
95Mesangial abnormality (HP:0001966)2.30778049
96Broad metatarsal (HP:0001783)2.28930139
97Squamous cell carcinoma (HP:0002860)2.28187646
98Distal lower limb muscle weakness (HP:0009053)2.27803229
99Abnormality of alanine metabolism (HP:0010916)2.27084547
100Hyperalaninemia (HP:0003348)2.27084547
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27084547
102Chest pain (HP:0100749)2.23727107
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22669060
104Sudden cardiac death (HP:0001645)2.22549757
105Respiratory failure (HP:0002878)2.22231276
106Increased intramyocellular lipid droplets (HP:0012240)2.20983017
107Acute lymphatic leukemia (HP:0006721)2.20514389
108Abnormality of skeletal muscle fiber size (HP:0012084)2.19734731
109Dysmetric saccades (HP:0000641)2.17329070
110Abnormality of male internal genitalia (HP:0000022)2.16801087
111Ragged-red muscle fibers (HP:0003200)2.16005994
112Neuroendocrine neoplasm (HP:0100634)2.15205505
113Lactic acidosis (HP:0003128)2.13469223
114Distal lower limb amyotrophy (HP:0008944)2.13275387
115Muscle stiffness (HP:0003552)2.12356406
116Dyschromatopsia (HP:0007641)2.10914035
117Hamartoma of the eye (HP:0010568)2.08224343
118Hypoplasia of the pons (HP:0012110)2.05930618
119Congestive heart failure (HP:0001635)2.05692750
120Exercise intolerance (HP:0003546)2.05575517
121Renal Fanconi syndrome (HP:0001994)2.04534384
122Ketosis (HP:0001946)2.04131095
123Areflexia of lower limbs (HP:0002522)2.03789556
124Portal hypertension (HP:0001409)2.03548073
125Abnormality of lateral ventricle (HP:0030047)2.00065432
126Renal cortical cysts (HP:0000803)1.99272610
127Autoimmune thrombocytopenia (HP:0001973)1.98536029
128Pancytopenia (HP:0001876)1.96560005
129Alveolar cell carcinoma (HP:0006519)1.96040820
130Intrahepatic cholestasis (HP:0001406)1.95063299
131Abnormality of the pons (HP:0007361)1.93665985
132Increased serum pyruvate (HP:0003542)1.91380770
133Abnormality of glycolysis (HP:0004366)1.91380770
134Neoplasm of the adrenal gland (HP:0100631)1.90458446
135Muscular dystrophy (HP:0003560)1.90104092
136Neoplasm of head and neck (HP:0012288)1.90047834
137Esophageal neoplasm (HP:0100751)1.90047834
138Neoplasm of the pancreas (HP:0002894)1.89749588
139Ulnar claw (HP:0001178)1.88937336
140Pancreatic fibrosis (HP:0100732)1.88718446
141Nephronophthisis (HP:0000090)1.87037221
142Hypoplastic ischia (HP:0003175)1.86756678
143Lipid accumulation in hepatocytes (HP:0006561)1.84621332
144Increased cerebral lipofuscin (HP:0011813)1.84176814
145Large for gestational age (HP:0001520)1.84147056
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83733174
147Gowers sign (HP:0003391)1.83237651
148Amelogenesis imperfecta (HP:0000705)1.81284273
149Gonadal dysgenesis (HP:0000133)1.81016135
150Abnormality of the hepatic vasculature (HP:0006707)1.80439686
151Neck muscle weakness (HP:0000467)1.79553902
152Tinnitus (HP:0000360)1.79127904
153Agammaglobulinemia (HP:0004432)1.78779152
154Lymphangioma (HP:0100764)1.78437634
155Abnormality of the foot musculature (HP:0001436)1.77903543
156Neoplasm of the adrenal cortex (HP:0100641)1.76569477
157Athetosis (HP:0002305)1.76297396
158Foot dorsiflexor weakness (HP:0009027)1.75717321
159Bone marrow hypocellularity (HP:0005528)1.74155956
160Lower limb amyotrophy (HP:0007210)1.74131246
161Mildly elevated creatine phosphokinase (HP:0008180)1.73797529
162Poikiloderma (HP:0001029)1.73716494
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.73034217
164Absent/shortened dynein arms (HP:0200106)1.73034217
165Pancreatic cysts (HP:0001737)1.72622753
166Increased hepatocellular lipid droplets (HP:0006565)1.72232513
167Neoplasm of the tracheobronchial system (HP:0100552)1.72012601
168Lethargy (HP:0001254)1.71080332
169Clumsiness (HP:0002312)1.70854237
170Myelodysplasia (HP:0002863)1.70829042
171Central scotoma (HP:0000603)1.70103848
172Hypertensive crisis (HP:0100735)1.69792536
173Granulocytopenia (HP:0001913)1.69633965
174Tubulointerstitial nephritis (HP:0001970)1.69290120
175Abnormal trabecular bone morphology (HP:0100671)1.67926399
176Severe combined immunodeficiency (HP:0004430)1.67536974
177Poor eye contact (HP:0000817)1.67271749
178Asplenia (HP:0001746)1.66336174
179Prominent supraorbital ridges (HP:0000336)1.64866567
180Hyperinsulinemic hypoglycemia (HP:0000825)1.64772114
181Increased serum lactate (HP:0002151)1.64616928
182Bulbous nose (HP:0000414)1.64523292
183Facial diplegia (HP:0001349)1.64148968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.14979393
2VRK25.32012611
3LMTK24.27598135
4MYLK4.00435116
5PHKG23.83488193
6PHKG13.83488193
7TAF13.67026476
8PDK33.43221107
9PDK43.43221107
10PKN23.09885933
11DMPK3.09699013
12TRIB33.02847917
13NUAK12.99385773
14CDK82.51405746
15TEC2.49843500
16OBSCN2.49478007
17VRK12.44680706
18BCKDK2.41041739
19SMG12.39989245
20TIE12.22197748
21MAP4K12.21221809
22BUB12.18844809
23PIK3CA2.18279073
24MUSK2.18039923
25MAPKAPK52.15851355
26PBK2.13838802
27GRK72.05594856
28PDK22.03020309
29ERN11.96338633
30NEK11.90555546
31CDK91.88871688
32DAPK11.88710264
33PINK11.80277436
34KIT1.78287865
35STK241.75428854
36PAK31.70300183
37TBK11.70126512
38BRSK21.66317808
39TGFBR11.65054290
40BMPR1B1.64660982
41JAK31.46984065
42FES1.46571388
43MKNK11.46542174
44CAMK2D1.40678675
45PRKD11.35376378
46WEE11.31270919
47ITK1.28040366
48BTK1.21566939
49ILK1.14154286
50TRPM71.10988709
51DAPK21.01731211
52SYK1.01560600
53MAPKAPK31.00665921
54WNK41.00428386
55PDGFRA0.98351357
56IKBKB0.96733754
57ADRBK20.96642856
58MAP3K50.94804190
59ROCK10.93351415
60TSSK60.92301355
61CSF1R0.90840885
62CAMK40.90215485
63MAPK120.88315664
64STK160.88096543
65EIF2AK20.87719278
66GRK50.86653615
67STK40.86445233
68MAP3K70.86119992
69DAPK30.85969038
70MAP3K40.84819147
71CDC70.84647018
72PNCK0.84407983
73PIK3CG0.84200252
74CDC42BPA0.83314818
75CDK70.81785402
76RIPK10.81204056
77MELK0.79641189
78PLK30.79010906
79CAMK2A0.78288378
80DYRK20.77114297
81STK38L0.76867158
82CCNB10.76843990
83STK380.76245125
84ARAF0.75267548
85CAMKK10.74650237
86PRKAA10.73108104
87FLT30.72392049
88ROCK20.70301864
89TNK20.69531993
90PKN10.65841032
91MAP2K30.64084581
92GRK10.63717880
93LCK0.63106426
94PRKAA20.62766699
95RPS6KC10.62641343
96RPS6KL10.62641343
97CSNK1G30.61588667
98CAMK10.61332937
99FRK0.60948161
100MAP2K40.60578756
101TXK0.59760993
102PTK2B0.59629887
103TLK10.59562369
104WNK10.59446548
105PLK20.59418272
106PRKD30.57370649
107PRKCE0.56414559
108RPS6KA50.56099636
109LATS20.55578103
110SCYL20.55354634
111TGFBR20.55025310
112RET0.54722322
113PDPK10.54192392
114EPHB10.53481763
115PIM20.53410132
116RPS6KA60.52541575
117CAMKK20.52371424
118MAP4K20.51704544
119PRKCH0.50842371
120MAP3K140.49853948
121PRKACB0.49469496
122RPS6KB20.49195891
123FGFR40.48803202
124ZAP700.48043012
125CSNK1G20.48005481
126MAP3K60.47929253
127PDK10.47316251
128LATS10.46918166
129CSNK1G10.46705381
130ATR0.46325544
131MAP3K30.45316689
132WNK30.45225367
133INSRR0.44621792
134MAPK150.43054858
135BRSK10.42033380
136PRKG20.41883431
137HIPK20.41430740
138ADRBK10.40937079
139KDR0.40678258
140PRKACA0.38787481
141CAMK2G0.38562916
142PRKACG0.37807911
143PRKCQ0.37428832
144JAK10.37244972
145CSNK1A1L0.36353299
146FER0.35500141
147PRKCD0.34624224
148MAPK40.34614528
149KSR20.34498174
150IGF1R0.34319531
151PLK10.33890769
152SIK10.33322284
153EEF2K0.33251017
154HCK0.33133239
155IKBKE0.32833767
156TAOK30.31386921
157PAK60.31270379
158MST40.31052431
159ZAK0.30424397
160RPS6KA10.29644981
161AKT20.29549237
162STK390.29484626
163MAP3K10.24774978
164NEK90.24672990
165JAK20.23534592
166EPHB20.23514651
167MAP2K70.21588444
168SGK30.20830556
169TAOK10.20009349
170EPHA30.19451462
171RPS6KA20.19269968
172PTK60.19161649
173PDGFRB0.18922629
174MARK20.18772700
175SGK10.18636270
176STK110.16432154
177NME20.15957503
178MAPK110.15522334

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.83519065
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.02642730
3Cardiac muscle contraction_Homo sapiens_hsa042604.01369586
4Dilated cardiomyopathy_Homo sapiens_hsa054143.58444607
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.38548974
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34901947
7Propanoate metabolism_Homo sapiens_hsa006403.26985262
8Parkinsons disease_Homo sapiens_hsa050123.16487704
9Oxidative phosphorylation_Homo sapiens_hsa001903.11532307
10Asthma_Homo sapiens_hsa053102.88200206
11Fatty acid degradation_Homo sapiens_hsa000712.88068359
12Base excision repair_Homo sapiens_hsa034102.66670868
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.59173510
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.39426216
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37077109
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35426178
17Alzheimers disease_Homo sapiens_hsa050102.35055861
18Carbon metabolism_Homo sapiens_hsa012002.27877040
19RNA polymerase_Homo sapiens_hsa030202.24225169
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22935476
21Fatty acid metabolism_Homo sapiens_hsa012122.18737045
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14658814
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12406418
24DNA replication_Homo sapiens_hsa030302.12033082
25Graft-versus-host disease_Homo sapiens_hsa053322.10115029
26Homologous recombination_Homo sapiens_hsa034402.09244545
27Linoleic acid metabolism_Homo sapiens_hsa005912.09053426
28Ribosome_Homo sapiens_hsa030102.06184237
29Pyrimidine metabolism_Homo sapiens_hsa002401.93750916
30Huntingtons disease_Homo sapiens_hsa050161.93134062
31Arachidonic acid metabolism_Homo sapiens_hsa005901.85307652
32Allograft rejection_Homo sapiens_hsa053301.83816740
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80895973
34Autoimmune thyroid disease_Homo sapiens_hsa053201.80341546
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76686537
36Fanconi anemia pathway_Homo sapiens_hsa034601.73896706
37Proteasome_Homo sapiens_hsa030501.72870157
38Pyruvate metabolism_Homo sapiens_hsa006201.72096370
39Viral myocarditis_Homo sapiens_hsa054161.65240027
40Pentose phosphate pathway_Homo sapiens_hsa000301.57204527
41One carbon pool by folate_Homo sapiens_hsa006701.54183381
42Nucleotide excision repair_Homo sapiens_hsa034201.51863676
43Antigen processing and presentation_Homo sapiens_hsa046121.45108345
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44645712
45Purine metabolism_Homo sapiens_hsa002301.43999640
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.43524929
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.43002365
48Ether lipid metabolism_Homo sapiens_hsa005651.42166771
49Type I diabetes mellitus_Homo sapiens_hsa049401.42035353
50Mismatch repair_Homo sapiens_hsa034301.40941068
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.38825371
52Butanoate metabolism_Homo sapiens_hsa006501.37982558
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33901116
54Rheumatoid arthritis_Homo sapiens_hsa053231.26876178
55Primary immunodeficiency_Homo sapiens_hsa053401.23378908
56Sulfur metabolism_Homo sapiens_hsa009201.20380192
57N-Glycan biosynthesis_Homo sapiens_hsa005101.19306308
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.18955128
59Selenocompound metabolism_Homo sapiens_hsa004501.17032573
60Fatty acid elongation_Homo sapiens_hsa000621.17011817
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13937750
62Adipocytokine signaling pathway_Homo sapiens_hsa049201.07214495
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04997833
64Hematopoietic cell lineage_Homo sapiens_hsa046401.03715885
65Insulin resistance_Homo sapiens_hsa049311.01728356
66PPAR signaling pathway_Homo sapiens_hsa033201.01448368
67Nitrogen metabolism_Homo sapiens_hsa009100.99515645
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96992118
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95857571
70Basal transcription factors_Homo sapiens_hsa030220.91991713
71Glucagon signaling pathway_Homo sapiens_hsa049220.91951219
72Insulin signaling pathway_Homo sapiens_hsa049100.90049211
73Calcium signaling pathway_Homo sapiens_hsa040200.88156222
74Type II diabetes mellitus_Homo sapiens_hsa049300.85541261
75Vitamin digestion and absorption_Homo sapiens_hsa049770.83790000
76RNA degradation_Homo sapiens_hsa030180.82198142
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81740165
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81542402
79Focal adhesion_Homo sapiens_hsa045100.80931487
80Leishmaniasis_Homo sapiens_hsa051400.80540026
81Biosynthesis of amino acids_Homo sapiens_hsa012300.79840452
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74508357
83Systemic lupus erythematosus_Homo sapiens_hsa053220.73769983
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73701903
85Oxytocin signaling pathway_Homo sapiens_hsa049210.73662752
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73074788
87Tryptophan metabolism_Homo sapiens_hsa003800.70509997
88Lysine degradation_Homo sapiens_hsa003100.68941836
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68422042
90ECM-receptor interaction_Homo sapiens_hsa045120.68208309
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.68070316
92Glycerolipid metabolism_Homo sapiens_hsa005610.66929663
93HIF-1 signaling pathway_Homo sapiens_hsa040660.66820010
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66525989
95beta-Alanine metabolism_Homo sapiens_hsa004100.65935600
96cAMP signaling pathway_Homo sapiens_hsa040240.65518074
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.65466429
98Renin secretion_Homo sapiens_hsa049240.65035618
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64359749
100AMPK signaling pathway_Homo sapiens_hsa041520.63560403
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61970172
102Gastric acid secretion_Homo sapiens_hsa049710.61246766
103Long-term depression_Homo sapiens_hsa047300.61205790
104Arginine biosynthesis_Homo sapiens_hsa002200.59574910
105Starch and sucrose metabolism_Homo sapiens_hsa005000.58680003
106Herpes simplex infection_Homo sapiens_hsa051680.58023965
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57217923
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57184062
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56629575
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55326477
111Circadian entrainment_Homo sapiens_hsa047130.54082304
112Chemical carcinogenesis_Homo sapiens_hsa052040.52508526
113Insulin secretion_Homo sapiens_hsa049110.50646107
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50557052
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49767708
116Glutathione metabolism_Homo sapiens_hsa004800.48615428
117GnRH signaling pathway_Homo sapiens_hsa049120.47609779
118Arginine and proline metabolism_Homo sapiens_hsa003300.46047539
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46003128
120Sulfur relay system_Homo sapiens_hsa041220.45206020
121Fat digestion and absorption_Homo sapiens_hsa049750.43893531
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.43048831
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.42818494
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42231090
125B cell receptor signaling pathway_Homo sapiens_hsa046620.42059523
126Spliceosome_Homo sapiens_hsa030400.42058899
127Fatty acid biosynthesis_Homo sapiens_hsa000610.40236990
128Amoebiasis_Homo sapiens_hsa051460.39554122
129Dorso-ventral axis formation_Homo sapiens_hsa043200.39382339
130Renal cell carcinoma_Homo sapiens_hsa052110.38499395
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38373652
132Serotonergic synapse_Homo sapiens_hsa047260.37438724
133Cholinergic synapse_Homo sapiens_hsa047250.37174224
134Non-homologous end-joining_Homo sapiens_hsa034500.36652851
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36266630
136Tight junction_Homo sapiens_hsa045300.35824839
137Gap junction_Homo sapiens_hsa045400.34621181
138RNA transport_Homo sapiens_hsa030130.34186757
139Peroxisome_Homo sapiens_hsa041460.33710128
140Phenylalanine metabolism_Homo sapiens_hsa003600.33666848
141Adherens junction_Homo sapiens_hsa045200.33329003
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33111615
143Epstein-Barr virus infection_Homo sapiens_hsa051690.32048276
144VEGF signaling pathway_Homo sapiens_hsa043700.31754261
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30993724
146Ovarian steroidogenesis_Homo sapiens_hsa049130.29979928
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29920878
148Estrogen signaling pathway_Homo sapiens_hsa049150.29186280
149Olfactory transduction_Homo sapiens_hsa047400.28956111
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27440152
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26764407
152Platelet activation_Homo sapiens_hsa046110.26392016
153Circadian rhythm_Homo sapiens_hsa047100.26239028
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26092925
155Long-term potentiation_Homo sapiens_hsa047200.25394282
156Morphine addiction_Homo sapiens_hsa050320.24916202
157mTOR signaling pathway_Homo sapiens_hsa041500.24900149
158Taste transduction_Homo sapiens_hsa047420.24264577
159Salivary secretion_Homo sapiens_hsa049700.22935925
160Proteoglycans in cancer_Homo sapiens_hsa052050.22134426
161Galactose metabolism_Homo sapiens_hsa000520.20492255
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19717658
163* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19499051
164Pancreatic secretion_Homo sapiens_hsa049720.16849939
165Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16821135
166Toxoplasmosis_Homo sapiens_hsa051450.16672785
167Dopaminergic synapse_Homo sapiens_hsa047280.16389152
168Amphetamine addiction_Homo sapiens_hsa050310.15794529
169Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15778008
170FoxO signaling pathway_Homo sapiens_hsa040680.14153609
171Leukocyte transendothelial migration_Homo sapiens_hsa046700.11763703
172Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11436954
173Small cell lung cancer_Homo sapiens_hsa052220.10853783
174Metabolic pathways_Homo sapiens_hsa011000.10781081
175* MAPK signaling pathway_Homo sapiens_hsa040100.07319600

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