FGF13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.44770760
2synaptic vesicle exocytosis (GO:0016079)5.27262288
3synaptic vesicle maturation (GO:0016188)5.14954417
4glutamate secretion (GO:0014047)5.10313613
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75479891
6vocalization behavior (GO:0071625)4.67650399
7regulation of synaptic vesicle exocytosis (GO:2000300)4.63121363
8protein localization to synapse (GO:0035418)4.59605912
9neuron cell-cell adhesion (GO:0007158)4.58910902
10detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.40777095
11detection of temperature stimulus involved in sensory perception (GO:0050961)4.40777095
12negative regulation of dendrite morphogenesis (GO:0050774)4.31295259
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29179852
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23983964
15pyrimidine nucleobase catabolic process (GO:0006208)4.16903277
16positive regulation of synaptic transmission, GABAergic (GO:0032230)4.13430406
17neuronal action potential propagation (GO:0019227)4.12495836
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.11605479
19regulation of synaptic vesicle transport (GO:1902803)4.11443234
20locomotory exploration behavior (GO:0035641)4.03229695
21cell migration in hindbrain (GO:0021535)4.02450484
22detection of temperature stimulus (GO:0016048)4.01716534
23proline transport (GO:0015824)4.00405729
24regulation of glutamate receptor signaling pathway (GO:1900449)3.96123376
25behavioral response to nicotine (GO:0035095)3.94681220
26neurotransmitter secretion (GO:0007269)3.82452180
27membrane depolarization during action potential (GO:0086010)3.76841383
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75010928
29presynaptic membrane assembly (GO:0097105)3.74949602
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.72111595
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.72105171
32regulation of neuronal synaptic plasticity (GO:0048168)3.70741224
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.69953740
34exploration behavior (GO:0035640)3.65637891
35innervation (GO:0060384)3.65430859
36neural tube formation (GO:0001841)3.65213373
37regulation of synapse structural plasticity (GO:0051823)3.63289025
38layer formation in cerebral cortex (GO:0021819)3.62144837
39neuronal action potential (GO:0019228)3.58627641
40detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58537413
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53263132
42negative regulation of dendrite development (GO:2000171)3.50675150
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.49344569
44kynurenine metabolic process (GO:0070189)3.49113936
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.49000701
46nucleobase catabolic process (GO:0046113)3.47625365
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47094597
48synaptic transmission, glutamatergic (GO:0035249)3.46938831
49indolalkylamine metabolic process (GO:0006586)3.45506601
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43197547
51negative regulation of microtubule polymerization (GO:0031115)3.41997919
52indole-containing compound catabolic process (GO:0042436)3.41921668
53indolalkylamine catabolic process (GO:0046218)3.41921668
54tryptophan catabolic process (GO:0006569)3.41921668
55neuron-neuron synaptic transmission (GO:0007270)3.39935303
56synaptic vesicle endocytosis (GO:0048488)3.39024153
57positive regulation of synapse maturation (GO:0090129)3.38616253
58glutamate receptor signaling pathway (GO:0007215)3.38145534
59neuron recognition (GO:0008038)3.33782402
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31471888
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30922444
62cellular potassium ion homeostasis (GO:0030007)3.30125892
63neurotransmitter-gated ion channel clustering (GO:0072578)3.29669840
64presynaptic membrane organization (GO:0097090)3.28920312
65central nervous system projection neuron axonogenesis (GO:0021952)3.28250448
66serotonin metabolic process (GO:0042428)3.27686724
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26628060
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25349309
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21417355
70regulation of postsynaptic membrane potential (GO:0060078)3.18944465
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.16480100
72membrane depolarization (GO:0051899)3.15597228
73regulation of vesicle fusion (GO:0031338)3.14726095
74neurotransmitter transport (GO:0006836)3.14489420
75cell communication by electrical coupling (GO:0010644)3.11725682
76regulation of synaptic transmission, GABAergic (GO:0032228)3.10692593
77central nervous system neuron axonogenesis (GO:0021955)3.10522972
78establishment of mitochondrion localization (GO:0051654)3.10015264
79regulation of neurotransmitter secretion (GO:0046928)3.09464656
80regulation of posttranscriptional gene silencing (GO:0060147)3.09263611
81regulation of gene silencing by miRNA (GO:0060964)3.09263611
82regulation of gene silencing by RNA (GO:0060966)3.09263611
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.08387745
84positive regulation of potassium ion transmembrane transport (GO:1901381)3.07550011
85signal peptide processing (GO:0006465)3.05583934
86detection of light stimulus involved in sensory perception (GO:0050962)3.04684722
87detection of light stimulus involved in visual perception (GO:0050908)3.04684722
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04075327
89gamma-aminobutyric acid transport (GO:0015812)3.02943755
90long-term memory (GO:0007616)3.01396429
91behavioral defense response (GO:0002209)3.00823750
92behavioral fear response (GO:0001662)3.00823750
93cell communication involved in cardiac conduction (GO:0086065)3.00822135
94primary amino compound metabolic process (GO:1901160)3.00787068
95mitochondrion transport along microtubule (GO:0047497)3.00757338
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00757338
97synapse assembly (GO:0007416)2.99596777
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.98352062
99retinal cone cell development (GO:0046549)2.97257291
100tryptophan metabolic process (GO:0006568)2.96871079
101regulation of sarcomere organization (GO:0060297)2.96802370
102indole-containing compound metabolic process (GO:0042430)2.96683350
103activation of protein kinase A activity (GO:0034199)2.94907313
104regulation of synaptic plasticity (GO:0048167)2.93838137
105dopamine transport (GO:0015872)2.93563516
106reflex (GO:0060004)2.93482031
107membrane repolarization (GO:0086009)2.92760519
108mating behavior (GO:0007617)2.92501603
109regulation of neurotransmitter levels (GO:0001505)2.90876523
110prepulse inhibition (GO:0060134)2.90525511
111sodium ion export (GO:0071436)2.89966092
112establishment of synaptic vesicle localization (GO:0097480)2.89891311
113synaptic vesicle transport (GO:0048489)2.89891311
114dopamine receptor signaling pathway (GO:0007212)2.89840477
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.89627976
116transmission of nerve impulse (GO:0019226)2.89494842
117behavioral response to ethanol (GO:0048149)2.89354408
118tachykinin receptor signaling pathway (GO:0007217)2.89160290
119positive regulation of membrane potential (GO:0045838)2.88539761
120photoreceptor cell maintenance (GO:0045494)2.88338235
121neuromuscular synaptic transmission (GO:0007274)2.88226527
122regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87848474
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.87767898
124regulation of translation, ncRNA-mediated (GO:0045974)2.87767898
125negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87767898
126protein localization to cilium (GO:0061512)2.87429407
127postsynaptic membrane organization (GO:0001941)2.87282488
128organelle transport along microtubule (GO:0072384)2.87263424
129urinary tract smooth muscle contraction (GO:0014848)2.86791917
130cerebellar Purkinje cell differentiation (GO:0021702)2.85975258
131axonal fasciculation (GO:0007413)2.85249161
132DNA double-strand break processing (GO:0000729)2.85213570
133regulation of dopamine secretion (GO:0014059)2.85060204
134sex differentiation (GO:0007548)2.84821955
135synaptic transmission (GO:0007268)2.84816899
136regulation of dendritic spine morphogenesis (GO:0061001)2.83585077
137regulation of neurotransmitter transport (GO:0051588)2.82835690
138negative regulation of calcium ion transport into cytosol (GO:0010523)2.82538779
139axon cargo transport (GO:0008088)2.82346313
140startle response (GO:0001964)2.80013806
141regulation of hippo signaling (GO:0035330)2.79564732
142fucose catabolic process (GO:0019317)2.79392851
143L-fucose metabolic process (GO:0042354)2.79392851
144L-fucose catabolic process (GO:0042355)2.79392851
145monoubiquitinated protein deubiquitination (GO:0035520)2.74422420
146cilium or flagellum-dependent cell motility (GO:0001539)2.71999552
147nonmotile primary cilium assembly (GO:0035058)2.69607074
148glycosphingolipid biosynthetic process (GO:0006688)2.67835659
149detection of mechanical stimulus involved in sensory perception (GO:0050974)2.62546869
150adult walking behavior (GO:0007628)2.61258398
151protein K11-linked deubiquitination (GO:0035871)2.60033556
152inner ear receptor stereocilium organization (GO:0060122)2.59761597
153establishment of protein localization to Golgi (GO:0072600)2.57743672
154cilium morphogenesis (GO:0060271)2.51256079
155synaptic transmission, cholinergic (GO:0007271)2.48611741
156cellular ketone body metabolic process (GO:0046950)2.47296542
157C4-dicarboxylate transport (GO:0015740)2.47285245
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45790344
159regulation of pigment cell differentiation (GO:0050932)2.43692888
160cellular response to sterol (GO:0036315)2.42869649
161protein polyglutamylation (GO:0018095)2.42565542
162benzene-containing compound metabolic process (GO:0042537)2.41457040
163auditory behavior (GO:0031223)2.41372056
164neurofilament cytoskeleton organization (GO:0060052)2.40357150
165regulation of action potential (GO:0098900)2.38253017
166cilium assembly (GO:0042384)2.38096358
167cilium organization (GO:0044782)2.38021410
168dopamine biosynthetic process (GO:0042416)2.37950224
169atrial cardiac muscle cell action potential (GO:0086014)2.37504750
170microtubule anchoring (GO:0034453)2.36481160
171photoreceptor cell development (GO:0042461)2.35026053
172axoneme assembly (GO:0035082)2.34837306
173appendage development (GO:0048736)2.34419618
174limb development (GO:0060173)2.34419618
175righting reflex (GO:0060013)2.33808456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60095043
2GBX2_23144817_ChIP-Seq_PC3_Human3.54619888
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16824381
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99473021
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99103055
6REST_21632747_ChIP-Seq_MESCs_Mouse2.71658968
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70257722
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63233055
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63233055
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56270193
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55668443
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.51969444
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49265950
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48146890
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44259779
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43481674
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.40037789
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.26639276
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20949014
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.19717651
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.19422905
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17584911
23TAF15_26573619_Chip-Seq_HEK293_Human2.15109236
24FUS_26573619_Chip-Seq_HEK293_Human2.14346080
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.11808116
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.08063882
27DROSHA_22980978_ChIP-Seq_HELA_Human2.07280576
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.01802429
29EWS_26573619_Chip-Seq_HEK293_Human2.01347245
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00638874
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93808882
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90549599
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83252101
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82898430
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79800429
36SMAD4_21799915_ChIP-Seq_A2780_Human1.79614124
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79442301
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78476152
39AR_21572438_ChIP-Seq_LNCaP_Human1.77955010
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71793005
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71727224
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65629862
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62757936
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62011055
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.58273299
46* P300_19829295_ChIP-Seq_ESCs_Human1.56709346
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53908065
48VDR_22108803_ChIP-Seq_LS180_Human1.51667242
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50202862
50CBP_20019798_ChIP-Seq_JUKART_Human1.50202862
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48727156
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45868513
53ZNF274_21170338_ChIP-Seq_K562_Hela1.44267918
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43692555
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42598272
56IGF1R_20145208_ChIP-Seq_DFB_Human1.42549379
57AR_25329375_ChIP-Seq_VCAP_Human1.38041867
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37932953
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36751622
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35352061
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34053382
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33821583
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33691953
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33607316
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.32521399
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31609822
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31580975
68TCF4_22108803_ChIP-Seq_LS180_Human1.30874182
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.30448992
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30102684
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.29080044
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27645086
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.26929389
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24751404
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.24680682
76RNF2_27304074_Chip-Seq_NSC_Mouse1.24645061
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.24468754
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24423894
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.24150882
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22628308
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21733830
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.21274554
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20663743
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20640604
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20303123
86* STAT3_23295773_ChIP-Seq_U87_Human1.19395113
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.17555373
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15839826
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15645040
90* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14500516
91AHR_22903824_ChIP-Seq_MCF-7_Human1.13785135
92AR_19668381_ChIP-Seq_PC3_Human1.12402478
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.12397192
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12353074
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12321656
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12253688
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.12244417
98IRF1_19129219_ChIP-ChIP_H3396_Human1.12240121
99P53_22387025_ChIP-Seq_ESCs_Mouse1.10862022
100SOX2_19829295_ChIP-Seq_ESCs_Human1.10827943
101NANOG_19829295_ChIP-Seq_ESCs_Human1.10827943
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09443867
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.07951100
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07933856
105* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07879603
106TP53_22573176_ChIP-Seq_HFKS_Human1.07508627
107* JUN_21703547_ChIP-Seq_K562_Human1.07498355
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06160947
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.05313406
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05035475
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04837720
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04404640
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04099558
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.04040190
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.03282656
116BCAT_22108803_ChIP-Seq_LS180_Human1.03269013
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02663257
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01900926
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01814780
120TCF4_23295773_ChIP-Seq_U87_Human1.01758980
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.01249661
122RUNX2_22187159_ChIP-Seq_PCA_Human1.00036891
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98734665
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98602531
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.98481711
126TP53_16413492_ChIP-PET_HCT116_Human0.98369435
127* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97251869
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96882668
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96395051
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95473704
131KDM2B_26808549_Chip-Seq_REH_Human0.94060931
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93026470
133CTCF_27219007_Chip-Seq_Bcells_Human0.92856285
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92069869
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90453109
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88873786
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.88296043
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87870467
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87870467
140ER_23166858_ChIP-Seq_MCF-7_Human0.87778294
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85340382
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84222965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22696051
2MP0002735_abnormal_chemical_nociception4.91444874
3MP0001968_abnormal_touch/_nociception4.84144587
4MP0004270_analgesia4.24235283
5MP0003880_abnormal_central_pattern4.19624547
6MP0002736_abnormal_nociception_after4.00199652
7MP0006276_abnormal_autonomic_nervous3.53866476
8MP0003635_abnormal_synaptic_transmissio3.44174719
9MP0002734_abnormal_mechanical_nocicepti3.39186852
10MP0002733_abnormal_thermal_nociception3.09026552
11MP0001986_abnormal_taste_sensitivity2.94217447
12MP0009745_abnormal_behavioral_response2.84658991
13MP0002063_abnormal_learning/memory/cond2.81867367
14MP0001970_abnormal_pain_threshold2.79034148
15MP0004858_abnormal_nervous_system2.66299033
16MP0002064_seizures2.56159384
17MP0002272_abnormal_nervous_system2.50707094
18MP0009046_muscle_twitch2.48861299
19MP0002572_abnormal_emotion/affect_behav2.41094611
20MP0002102_abnormal_ear_morphology2.36972318
21MP0005423_abnormal_somatic_nervous2.29184240
22MP0002184_abnormal_innervation2.23021045
23MP0008877_abnormal_DNA_methylation2.18893638
24MP0003890_abnormal_embryonic-extraembry2.16280641
25MP0002067_abnormal_sensory_capabilities2.12777315
26MP0008057_abnormal_DNA_replication2.09130441
27MP0001440_abnormal_grooming_behavior1.98013294
28MP0001486_abnormal_startle_reflex1.93588006
29MP0001501_abnormal_sleep_pattern1.93450343
30MP0001984_abnormal_olfaction1.83127479
31MP0003195_calcinosis1.79251181
32MP0002822_catalepsy1.76441131
33MP0004811_abnormal_neuron_physiology1.75944944
34MP0000778_abnormal_nervous_system1.75846334
35MP0005386_behavior/neurological_phenoty1.62658178
36MP0004924_abnormal_behavior1.62658178
37MP0001905_abnormal_dopamine_level1.59940419
38MP0005253_abnormal_eye_physiology1.59153299
39MP0002557_abnormal_social/conspecific_i1.54133674
40MP0000955_abnormal_spinal_cord1.52647552
41MP0002909_abnormal_adrenal_gland1.50570798
42MP0003329_amyloid_beta_deposits1.43755902
43MP0000751_myopathy1.42075330
44MP0002882_abnormal_neuron_morphology1.40198976
45MP0004147_increased_porphyrin_level1.37210432
46MP0003119_abnormal_digestive_system1.36987506
47MP0003136_yellow_coat_color1.34658870
48MP0006072_abnormal_retinal_apoptosis1.34383286
49MP0001188_hyperpigmentation1.33519946
50MP0008569_lethality_at_weaning1.31947112
51MP0010386_abnormal_urinary_bladder1.31386097
52MP0002837_dystrophic_cardiac_calcinosis1.31310369
53MP0004043_abnormal_pH_regulation1.30851776
54MP0002751_abnormal_autonomic_nervous1.26466558
55MP0004133_heterotaxia1.26000754
56MP0002066_abnormal_motor_capabilities/c1.25086285
57MP0003121_genomic_imprinting1.22584387
58MP0003122_maternal_imprinting1.19144360
59MP0001529_abnormal_vocalization1.16718828
60MP0000427_abnormal_hair_cycle1.16050217
61MP0009780_abnormal_chondrocyte_physiolo1.14829728
62MP0005645_abnormal_hypothalamus_physiol1.13925806
63MP0004142_abnormal_muscle_tone1.13704499
64MP0003879_abnormal_hair_cell1.13613833
65MP0006292_abnormal_olfactory_placode1.10052874
66MP0003937_abnormal_limbs/digits/tail_de1.08637166
67MP0001502_abnormal_circadian_rhythm1.06971882
68MP0003633_abnormal_nervous_system1.05353452
69MP0004145_abnormal_muscle_electrophysio1.03193463
70MP0002234_abnormal_pharynx_morphology1.01011127
71MP0004085_abnormal_heartbeat0.99042925
72MP0000372_irregular_coat_pigmentation0.98386477
73MP0003718_maternal_effect0.97706759
74MP0008872_abnormal_physiological_respon0.96819819
75MP0004215_abnormal_myocardial_fiber0.93804851
76MP0005646_abnormal_pituitary_gland0.92743432
77MP0002229_neurodegeneration0.90761015
78MP0002938_white_spotting0.90207840
79MP0004484_altered_response_of0.89525638
80MP0005535_abnormal_body_temperature0.88663915
81MP0003631_nervous_system_phenotype0.88578040
82MP0002752_abnormal_somatic_nervous0.88134604
83MP0002653_abnormal_ependyma_morphology0.87905912
84MP0005187_abnormal_penis_morphology0.87259896
85MP0004742_abnormal_vestibular_system0.85272876
86MP0005195_abnormal_posterior_eye0.85067148
87MP0002152_abnormal_brain_morphology0.84330626
88MP0008874_decreased_physiological_sensi0.83198652
89MP0000383_abnormal_hair_follicle0.81648667
90MP0000026_abnormal_inner_ear0.80010250
91MP0004885_abnormal_endolymph0.79468230
92MP0003634_abnormal_glial_cell0.79247784
93MP0002069_abnormal_eating/drinking_beha0.78167732
94MP0003698_abnormal_male_reproductive0.77063765
95MP0003861_abnormal_nervous_system0.76279953
96MP0004036_abnormal_muscle_relaxation0.73724812
97MP0001963_abnormal_hearing_physiology0.73686606
98MP0000749_muscle_degeneration0.69633707
99MP0005670_abnormal_white_adipose0.69585508
100MP0005551_abnormal_eye_electrophysiolog0.68331220
101MP0005171_absent_coat_pigmentation0.68058330
102MP0000049_abnormal_middle_ear0.67858368
103MP0001293_anophthalmia0.67774533
104MP0005499_abnormal_olfactory_system0.67057622
105MP0005394_taste/olfaction_phenotype0.67057622
106MP0002876_abnormal_thyroid_physiology0.66979844
107MP0000569_abnormal_digit_pigmentation0.66722956
108MP0003137_abnormal_impulse_conducting0.66085469
109MP0008775_abnormal_heart_ventricle0.65666006
110MP0004510_myositis0.63165799
111MP0001348_abnormal_lacrimal_gland0.62266557
112MP0003787_abnormal_imprinting0.61368101
113MP0001664_abnormal_digestion0.59814561
114MP0002972_abnormal_cardiac_muscle0.59262754
115MP0002638_abnormal_pupillary_reflex0.59185483
116MP0000604_amyloidosis0.59127198
117MP0005620_abnormal_muscle_contractility0.58170929
118MP0004233_abnormal_muscle_weight0.58115447
119MP0001299_abnormal_eye_distance/0.57718774
120MP0000747_muscle_weakness0.57615248
121MP0000631_abnormal_neuroendocrine_gland0.55066534
122MP0002090_abnormal_vision0.54999287
123MP0003646_muscle_fatigue0.54534358
124MP0004130_abnormal_muscle_cell0.53667565
125MP0001943_abnormal_respiration0.52648047
126MP0001485_abnormal_pinna_reflex0.51742942
127MP0005409_darkened_coat_color0.50083216
128MP0000920_abnormal_myelination0.49826561
129MP0004084_abnormal_cardiac_muscle0.49532810
130MP0003632_abnormal_nervous_system0.49374464
131MP0001177_atelectasis0.46215232

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.70169360
2Focal motor seizures (HP:0011153)6.38380616
3Focal seizures (HP:0007359)5.17241578
4Visual hallucinations (HP:0002367)4.67267593
5Epileptic encephalopathy (HP:0200134)4.48032139
6Febrile seizures (HP:0002373)4.33558263
7Atonic seizures (HP:0010819)4.28489993
8Progressive cerebellar ataxia (HP:0002073)4.16219368
9Pheochromocytoma (HP:0002666)4.12281213
10Limb dystonia (HP:0002451)4.08019801
11Action tremor (HP:0002345)3.89458025
12Pancreatic cysts (HP:0001737)3.82554454
13Termporal pattern (HP:0011008)3.78708791
14Insidious onset (HP:0003587)3.78708791
15Absence seizures (HP:0002121)3.77426994
16Neuroendocrine neoplasm (HP:0100634)3.72451982
17Dialeptic seizures (HP:0011146)3.51925812
18Pancreatic fibrosis (HP:0100732)3.47555667
19Generalized tonic-clonic seizures (HP:0002069)3.41807273
20True hermaphroditism (HP:0010459)3.36688053
21Supranuclear gaze palsy (HP:0000605)3.35924409
22Ulnar claw (HP:0001178)3.35684575
23Ankle clonus (HP:0011448)3.35535719
24Failure to thrive in infancy (HP:0001531)3.08225938
25Abnormality of pain sensation (HP:0010832)3.05381672
26Impaired pain sensation (HP:0007328)3.05381672
27Abnormality of the labia minora (HP:0012880)2.98654290
28Urinary urgency (HP:0000012)2.96352186
29Urinary bladder sphincter dysfunction (HP:0002839)2.94239680
30Nephronophthisis (HP:0000090)2.92045716
31Protruding tongue (HP:0010808)2.89213666
32Medial flaring of the eyebrow (HP:0010747)2.87786615
33Abnormality of midbrain morphology (HP:0002418)2.87120340
34Molar tooth sign on MRI (HP:0002419)2.87120340
35Abnormal eating behavior (HP:0100738)2.86497746
36Amblyopia (HP:0000646)2.82793395
37Progressive inability to walk (HP:0002505)2.82263150
38Impaired vibration sensation in the lower limbs (HP:0002166)2.82124125
39Hyperventilation (HP:0002883)2.76219308
40Truncal ataxia (HP:0002078)2.75109635
41Abnormality of the corticospinal tract (HP:0002492)2.73843865
42Mutism (HP:0002300)2.69878874
43Chronic hepatic failure (HP:0100626)2.68574500
44Depression (HP:0000716)2.65557900
45Hypoventilation (HP:0002791)2.61336112
46Congenital primary aphakia (HP:0007707)2.59524473
47Poor eye contact (HP:0000817)2.59176513
48Myotonia (HP:0002486)2.58112210
49Broad-based gait (HP:0002136)2.56014852
50Anxiety (HP:0000739)2.55845419
51Neoplasm of the peripheral nervous system (HP:0100007)2.55775047
52Abnormality of the renal medulla (HP:0100957)2.55448482
53Genital tract atresia (HP:0001827)2.54795371
54Abnormal hair whorl (HP:0010721)2.50191252
55Vaginal atresia (HP:0000148)2.49922823
56Congenital stationary night blindness (HP:0007642)2.49740286
57Abolished electroretinogram (ERG) (HP:0000550)2.48809629
58Gaze-evoked nystagmus (HP:0000640)2.46064536
59Polyphagia (HP:0002591)2.39724445
60Cystic liver disease (HP:0006706)2.39669794
61Ventricular fibrillation (HP:0001663)2.39526524
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.38046197
63Abnormal social behavior (HP:0012433)2.36625901
64Impaired social interactions (HP:0000735)2.36625901
65Nephrogenic diabetes insipidus (HP:0009806)2.36375916
66Abnormality of the renal cortex (HP:0011035)2.35700729
67Spastic gait (HP:0002064)2.35090254
68Dysautonomia (HP:0002459)2.34999828
69Lower limb muscle weakness (HP:0007340)2.33899601
70Hypothermia (HP:0002045)2.33524154
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.32402522
72Attenuation of retinal blood vessels (HP:0007843)2.31666305
73Dysmetria (HP:0001310)2.31609793
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30784923
75Hypoplasia of the brainstem (HP:0002365)2.30784923
76Dysdiadochokinesis (HP:0002075)2.30442726
77Lissencephaly (HP:0001339)2.29636724
78Fetal akinesia sequence (HP:0001989)2.26959106
79Torticollis (HP:0000473)2.24122631
80Inability to walk (HP:0002540)2.19780510
81Pendular nystagmus (HP:0012043)2.19289296
82Epileptiform EEG discharges (HP:0011182)2.18831112
83Postural instability (HP:0002172)2.17574517
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16138539
85Abnormality of alanine metabolism (HP:0010916)2.16138539
86Hyperalaninemia (HP:0003348)2.16138539
87Type II lissencephaly (HP:0007260)2.15276973
88Steppage gait (HP:0003376)2.12405714
89EEG with generalized epileptiform discharges (HP:0011198)2.12249815
90Scanning speech (HP:0002168)2.11610234
91Poor coordination (HP:0002370)2.11331390
92Abnormality of the vocal cords (HP:0008777)2.11016257
93Intestinal atresia (HP:0011100)2.10468292
94Drooling (HP:0002307)2.10272116
95Excessive salivation (HP:0003781)2.10272116
96Genetic anticipation (HP:0003743)2.09975812
97Hypercortisolism (HP:0001578)2.09643743
98Clumsiness (HP:0002312)2.07406562
99Bradykinesia (HP:0002067)2.07349137
100Gait imbalance (HP:0002141)2.07055302
101Hammertoe (HP:0001765)2.06649237
102Papilledema (HP:0001085)2.05737110
103Sclerocornea (HP:0000647)2.05147072
104Abnormality of the lower motor neuron (HP:0002366)2.04513313
105Fair hair (HP:0002286)2.04076216
106Patellar aplasia (HP:0006443)2.03800145
107Retinal dysplasia (HP:0007973)2.03238357
108Bony spicule pigmentary retinopathy (HP:0007737)2.01977240
109Focal dystonia (HP:0004373)2.01568232
110Hemiparesis (HP:0001269)2.01045336
111Sudden death (HP:0001699)2.00192715
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.00087920
113Anencephaly (HP:0002323)1.99323405
114Hypsarrhythmia (HP:0002521)1.99017089
115Specific learning disability (HP:0001328)1.97646470
116Oligodactyly (hands) (HP:0001180)1.96873315
117Rapidly progressive (HP:0003678)1.96755714
118Cerebral inclusion bodies (HP:0100314)1.95220167
119Poor suck (HP:0002033)1.94563403
120Birth length less than 3rd percentile (HP:0003561)1.94354249
121Morphological abnormality of the pyramidal tract (HP:0002062)1.94291896
122Megalencephaly (HP:0001355)1.94121572
123Volvulus (HP:0002580)1.93379996
124Keratoconus (HP:0000563)1.93306059
125Increased corneal curvature (HP:0100692)1.93306059
126Psychosis (HP:0000709)1.92030230
127Bradycardia (HP:0001662)1.91503526
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.90982326
129Agitation (HP:0000713)1.89682197
130Foot dorsiflexor weakness (HP:0009027)1.89341394
131Colon cancer (HP:0003003)1.88483809
132Central scotoma (HP:0000603)1.88395003
133Craniofacial dystonia (HP:0012179)1.87999023
134Incomplete penetrance (HP:0003829)1.84941357
135Abnormality of macular pigmentation (HP:0008002)1.83947965
136Aplasia/Hypoplasia of the patella (HP:0006498)1.83548563
137Akinesia (HP:0002304)1.83346783
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82579929
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.82579929
140Neurofibrillary tangles (HP:0002185)1.82541691
141Impaired vibratory sensation (HP:0002495)1.82439452
142Absent speech (HP:0001344)1.82198317
143Postaxial foot polydactyly (HP:0001830)1.81866538
144Small hand (HP:0200055)1.81529443
145Thyroid carcinoma (HP:0002890)1.80337661
146Dyskinesia (HP:0100660)1.80024942
147Abnormal EKG (HP:0003115)1.79308978
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.78332524
149Tubular atrophy (HP:0000092)1.78020429
150Short foot (HP:0001773)1.77444084
151Delusions (HP:0000746)1.77160154
152Abnormality of binocular vision (HP:0011514)1.76611983
153Congenital hepatic fibrosis (HP:0002612)1.75993298
154Optic nerve hypoplasia (HP:0000609)1.75626351
155Pachygyria (HP:0001302)1.74392895
156Exotropia (HP:0000577)1.74313038
157Abnormality of the astrocytes (HP:0100707)1.71189140
158Astrocytoma (HP:0009592)1.71189140
159Labial hypoplasia (HP:0000066)1.71087150
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70931099
161Broad foot (HP:0001769)1.70344890
162Glioma (HP:0009733)1.70061695
163Decreased central vision (HP:0007663)1.69966340
164Postaxial hand polydactyly (HP:0001162)1.68503273
165Dandy-Walker malformation (HP:0001305)1.67778674
166Cerebellar dysplasia (HP:0007033)1.67493182
167Polydipsia (HP:0001959)1.63731184
168Abnormal drinking behavior (HP:0030082)1.63731184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.79069741
2NTRK33.74872519
3MAP3K93.73469631
4MINK13.36661151
5MARK13.13007479
6MAP3K122.99462657
7ACVR1B2.95079427
8WNK32.92808911
9MAP3K42.72009554
10CASK2.71707811
11EPHA42.70897185
12NTRK12.68893857
13KSR22.58661572
14GRK52.38884222
15RIPK42.37592539
16MAP2K72.31021872
17DAPK22.07770662
18MKNK22.05229257
19MAP4K21.95192854
20PAK61.91737431
21TRIM281.91463308
22MAP2K41.85582340
23OXSR11.79943580
24PHKG11.66067884
25PHKG21.66067884
26KSR11.64533307
27ARAF1.62868584
28LMTK21.62806773
29SIK31.61653333
30MAPK131.60645636
31PLK21.59824986
32ZAK1.58599005
33MAP3K21.55594303
34NTRK21.45774310
35PRKD31.45050136
36CDK51.40738162
37PRPF4B1.34099452
38GRK11.32393926
39LIMK11.31581546
40INSRR1.30945429
41STK38L1.29951108
42LATS21.27925329
43DAPK11.27730976
44RET1.25318534
45NUAK11.21730651
46MKNK11.18477613
47SGK2231.15121495
48SGK4941.15121495
49PRKCG1.14254444
50CSNK1G11.10265919
51CAMKK11.10042881
52SIK21.08800033
53TNIK1.08188672
54ADRBK21.07846144
55SGK21.07003522
56CAMK2A1.02587590
57EPHA31.01983632
58CDK141.00697060
59UHMK11.00547015
60STK390.96086113
61CSNK1A1L0.93146921
62OBSCN0.89517881
63CDK180.89059350
64PINK10.88176869
65PTK2B0.86232574
66CSNK1G20.85656336
67MAP2K10.84080325
68FER0.82421461
69TGFBR10.79684502
70CDK150.79373737
71PRKCE0.78234407
72STK380.77693045
73PLK40.75479796
74TAOK30.75233453
75WNK40.74717673
76NME10.73694907
77SGK30.73138834
78FES0.72301676
79PAK30.71072652
80BCR0.70718823
81PNCK0.70518789
82CAMKK20.70481993
83MAP3K10.69931214
84MAPKAPK50.69343213
85MATK0.68739038
86CAMK2B0.68667532
87CDK11A0.68573814
88RPS6KA20.67202595
89DYRK1A0.61708095
90PRKCH0.61527557
91BRSK20.61497039
92CAMK2D0.61029379
93RAF10.59769851
94PKN10.59227898
95DYRK20.59157328
96NEK10.59071361
97PLK30.59014350
98LATS10.54681833
99CAMK10.54550449
100PRKCZ0.53954446
101BMPR1B0.53675883
102MAP3K130.53217846
103CSNK1G30.49708768
104CAMK40.49200467
105ADRBK10.49074888
106CAMK1G0.49013864
107BMPR20.46797221
108FGFR20.46653925
109PDK40.46431310
110PDK30.46431310
111TNK20.46197442
112PDK10.46029663
113CAMK2G0.44609179
114DYRK30.44150970
115SGK10.43277729
116PRKAA10.43200928
117STK110.42593068
118CSNK1D0.42545728
119STK30.42488166
120PIK3CA0.41567443
121MAP3K70.39883591
122CSNK1A10.39167148
123PIK3CG0.39091318
124TIE10.39053756
125MAP2K60.38642085
126CDK190.38281015
127AKT30.37509297
128NLK0.37434008
129ROCK20.36269082
130BRAF0.35993870
131MARK20.35492227
132PRKACA0.35280494
133FYN0.35271936
134ERBB20.35268656
135PRKG10.34939794
136CCNB10.34662655
137CDK30.34571806
138PRKACB0.34557611
139PDPK10.34470539
140MAPK100.34086053
141PRKAA20.33792447
142TYRO30.33773704
143CDC42BPA0.32482436
144RPS6KA30.32093663
145PLK10.32012959
146ERBB30.31804482
147SRPK10.31731892
148PRKCB0.29115343

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.71311724
2Nicotine addiction_Homo sapiens_hsa050333.34486146
3Butanoate metabolism_Homo sapiens_hsa006502.58176797
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56814722
5Olfactory transduction_Homo sapiens_hsa047402.56306480
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50488017
7GABAergic synapse_Homo sapiens_hsa047272.41013939
8Circadian entrainment_Homo sapiens_hsa047132.39036763
9Long-term potentiation_Homo sapiens_hsa047202.36704743
10Morphine addiction_Homo sapiens_hsa050322.21136684
11Glutamatergic synapse_Homo sapiens_hsa047242.19864403
12Dopaminergic synapse_Homo sapiens_hsa047282.19776267
13Amphetamine addiction_Homo sapiens_hsa050312.11758260
14Insulin secretion_Homo sapiens_hsa049112.09154715
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91795249
16Salivary secretion_Homo sapiens_hsa049701.88425089
17Taste transduction_Homo sapiens_hsa047421.88289379
18Cholinergic synapse_Homo sapiens_hsa047251.87930743
19Collecting duct acid secretion_Homo sapiens_hsa049661.87718389
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80704873
21Serotonergic synapse_Homo sapiens_hsa047261.78851627
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.78507442
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72398705
24Propanoate metabolism_Homo sapiens_hsa006401.64181412
25Tryptophan metabolism_Homo sapiens_hsa003801.63059810
26Cardiac muscle contraction_Homo sapiens_hsa042601.57340953
27Gastric acid secretion_Homo sapiens_hsa049711.57307463
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56504701
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.53184854
30Renin secretion_Homo sapiens_hsa049241.52505486
31Cocaine addiction_Homo sapiens_hsa050301.49674219
32Long-term depression_Homo sapiens_hsa047301.49209660
33Calcium signaling pathway_Homo sapiens_hsa040201.48692507
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46811578
35Oxytocin signaling pathway_Homo sapiens_hsa049211.44049144
36Fanconi anemia pathway_Homo sapiens_hsa034601.41640179
37Linoleic acid metabolism_Homo sapiens_hsa005911.41022088
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40481974
39GnRH signaling pathway_Homo sapiens_hsa049121.38718448
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36335249
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34503572
42ABC transporters_Homo sapiens_hsa020101.34024710
43Selenocompound metabolism_Homo sapiens_hsa004501.33160843
44Nitrogen metabolism_Homo sapiens_hsa009101.32863501
45Gap junction_Homo sapiens_hsa045401.31289728
46Ether lipid metabolism_Homo sapiens_hsa005651.28699056
47Homologous recombination_Homo sapiens_hsa034401.27474744
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25990072
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19696285
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18541640
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15574566
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15259300
53Oxidative phosphorylation_Homo sapiens_hsa001901.15222864
54Axon guidance_Homo sapiens_hsa043601.13703880
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13464531
56Vibrio cholerae infection_Homo sapiens_hsa051101.12110307
57Basal transcription factors_Homo sapiens_hsa030221.09616233
58Parkinsons disease_Homo sapiens_hsa050121.07953003
59Glioma_Homo sapiens_hsa052141.07367939
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04799171
61cAMP signaling pathway_Homo sapiens_hsa040241.04034102
62Alzheimers disease_Homo sapiens_hsa050101.03691654
63Estrogen signaling pathway_Homo sapiens_hsa049151.03427928
64ErbB signaling pathway_Homo sapiens_hsa040121.02613348
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.01565269
66Melanogenesis_Homo sapiens_hsa049161.00631999
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99390892
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97399046
69Type II diabetes mellitus_Homo sapiens_hsa049300.97179356
70beta-Alanine metabolism_Homo sapiens_hsa004100.95267400
71Dorso-ventral axis formation_Homo sapiens_hsa043200.90967571
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.88339068
73Steroid biosynthesis_Homo sapiens_hsa001000.85360212
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85146677
75Oocyte meiosis_Homo sapiens_hsa041140.82761045
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.82188716
77Protein export_Homo sapiens_hsa030600.80971052
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79936225
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79811460
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.78887614
81Non-homologous end-joining_Homo sapiens_hsa034500.78237831
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77414848
83Retinol metabolism_Homo sapiens_hsa008300.77210150
84RNA polymerase_Homo sapiens_hsa030200.74927456
85Phototransduction_Homo sapiens_hsa047440.74575269
86Histidine metabolism_Homo sapiens_hsa003400.74066668
87Dilated cardiomyopathy_Homo sapiens_hsa054140.73205386
88Choline metabolism in cancer_Homo sapiens_hsa052310.71884043
89Glycerolipid metabolism_Homo sapiens_hsa005610.71570394
90Ovarian steroidogenesis_Homo sapiens_hsa049130.68899853
91RNA degradation_Homo sapiens_hsa030180.68470882
92VEGF signaling pathway_Homo sapiens_hsa043700.67883861
93Endometrial cancer_Homo sapiens_hsa052130.67725064
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65821950
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64790533
96Pancreatic secretion_Homo sapiens_hsa049720.63578990
97Thyroid hormone synthesis_Homo sapiens_hsa049180.62673914
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62517315
99Caffeine metabolism_Homo sapiens_hsa002320.62157975
100* MAPK signaling pathway_Homo sapiens_hsa040100.62084217
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61705099
102Insulin signaling pathway_Homo sapiens_hsa049100.61068642
103Fatty acid biosynthesis_Homo sapiens_hsa000610.60970840
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.60758341
105Huntingtons disease_Homo sapiens_hsa050160.60539105
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60532853
107Chemical carcinogenesis_Homo sapiens_hsa052040.58464395
108Peroxisome_Homo sapiens_hsa041460.58151405
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57467359
110Lysine degradation_Homo sapiens_hsa003100.56646757
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.56453413
112Endocytosis_Homo sapiens_hsa041440.55282474
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53866526
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53110438
115Glucagon signaling pathway_Homo sapiens_hsa049220.52955720
116Fatty acid metabolism_Homo sapiens_hsa012120.52300690
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.51755840
118Hippo signaling pathway_Homo sapiens_hsa043900.49883126
119Thyroid cancer_Homo sapiens_hsa052160.49560930
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49384415
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49353371
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49231010
123* Ras signaling pathway_Homo sapiens_hsa040140.48355485
124Alcoholism_Homo sapiens_hsa050340.47476716
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46632038
126* Rap1 signaling pathway_Homo sapiens_hsa040150.45824022
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45384015
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.45341162
129mTOR signaling pathway_Homo sapiens_hsa041500.44497888
130Phagosome_Homo sapiens_hsa041450.43046910
131Hedgehog signaling pathway_Homo sapiens_hsa043400.42378078
132Prolactin signaling pathway_Homo sapiens_hsa049170.42119138
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41963666
134Purine metabolism_Homo sapiens_hsa002300.41310538
135Fatty acid degradation_Homo sapiens_hsa000710.40460273
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40045172
137African trypanosomiasis_Homo sapiens_hsa051430.38519239
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38505940
139Rheumatoid arthritis_Homo sapiens_hsa053230.38141448
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37670904
141Regulation of autophagy_Homo sapiens_hsa041400.37637956
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36982726
143Non-small cell lung cancer_Homo sapiens_hsa052230.36790248
144Type I diabetes mellitus_Homo sapiens_hsa049400.36728682
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36305790
146Renal cell carcinoma_Homo sapiens_hsa052110.35822990
147Salmonella infection_Homo sapiens_hsa051320.35438461
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35217969
149TGF-beta signaling pathway_Homo sapiens_hsa043500.34716633
150Circadian rhythm_Homo sapiens_hsa047100.34679318
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34264983
152Colorectal cancer_Homo sapiens_hsa052100.33724577
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33553127
154Inositol phosphate metabolism_Homo sapiens_hsa005620.31714356

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