FGD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.90126261
2G-protein coupled receptor internalization (GO:0002031)4.72482455
3neural tube formation (GO:0001841)4.33276805
4establishment of protein localization to Golgi (GO:0072600)4.14375255
5nucleobase catabolic process (GO:0046113)4.09981792
6histone H3-K4 trimethylation (GO:0080182)4.04197783
7protein targeting to Golgi (GO:0000042)4.01184681
8behavioral response to nicotine (GO:0035095)3.77066049
9retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73382679
10kidney morphogenesis (GO:0060993)3.65145834
11response to pheromone (GO:0019236)3.50390109
12superoxide anion generation (GO:0042554)3.46361973
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33430009
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.30814337
15regulation of translation, ncRNA-mediated (GO:0045974)3.30814337
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30814337
17negative regulation of granulocyte differentiation (GO:0030853)3.29777155
18positive regulation of cellular amide metabolic process (GO:0034250)3.25345674
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24543662
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.24543662
21modulation by symbiont of host immune response (GO:0052553)3.24543662
22positive regulation by symbiont of host defense response (GO:0052509)3.24543662
23modulation by symbiont of host defense response (GO:0052031)3.24543662
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24543662
25developmental pigmentation (GO:0048066)3.16160252
26olfactory bulb development (GO:0021772)3.14317385
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13835467
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.12163659
29regulation of pigment cell differentiation (GO:0050932)3.08824521
30response to host immune response (GO:0052572)3.07243727
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07243727
32single strand break repair (GO:0000012)3.03684303
33mitochondrion distribution (GO:0048311)3.02001259
34regulation of gene silencing by RNA (GO:0060966)3.00565729
35regulation of posttranscriptional gene silencing (GO:0060147)3.00565729
36regulation of gene silencing by miRNA (GO:0060964)3.00565729
37epithelial cilium movement (GO:0003351)2.98192808
38protein localization to cilium (GO:0061512)2.98070907
39regulation of germinal center formation (GO:0002634)2.98044598
40retinal cone cell development (GO:0046549)2.97626669
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.94824504
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92512071
43L-fucose catabolic process (GO:0042355)2.92089048
44fucose catabolic process (GO:0019317)2.92089048
45L-fucose metabolic process (GO:0042354)2.92089048
46cell morphogenesis involved in neuron differentiation (GO:0048667)2.90506517
47somite development (GO:0061053)2.90185922
48regulation of non-canonical Wnt signaling pathway (GO:2000050)2.89588514
49protein localization to Golgi apparatus (GO:0034067)2.88858868
50protein polyglutamylation (GO:0018095)2.88190039
51DNA strand renaturation (GO:0000733)2.87822293
52early endosome to late endosome transport (GO:0045022)2.87783342
53startle response (GO:0001964)2.85880396
54presynaptic membrane assembly (GO:0097105)2.81060160
55righting reflex (GO:0060013)2.79119587
56histone H3-K36 demethylation (GO:0070544)2.79101099
57atrial cardiac muscle cell action potential (GO:0086014)2.78001149
58germinal center formation (GO:0002467)2.77305689
59positive regulation of interleukin-1 beta secretion (GO:0050718)2.77174916
60I-kappaB phosphorylation (GO:0007252)2.77121770
61acrosome reaction (GO:0007340)2.76406216
62positive regulation of cardiac muscle cell differentiation (GO:2000727)2.74209386
63ionotropic glutamate receptor signaling pathway (GO:0035235)2.73609743
64neutrophil mediated immunity (GO:0002446)2.71305850
65modulation by symbiont of host cellular process (GO:0044068)2.70230436
66regulation of meiosis I (GO:0060631)2.69664761
67modulation by virus of host process (GO:0019054)2.69601265
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68811385
69positive regulation of microtubule polymerization (GO:0031116)2.68244218
70negative regulation of dendrite development (GO:2000171)2.66454126
71spinal cord motor neuron differentiation (GO:0021522)2.65297409
72central nervous system neuron axonogenesis (GO:0021955)2.64338804
73reflex (GO:0060004)2.64161241
74axonal fasciculation (GO:0007413)2.61488635
75regulation of action potential (GO:0098900)2.61063985
76regulation of DNA endoreduplication (GO:0032875)2.60984401
77response to host (GO:0075136)2.60146754
78response to host defenses (GO:0052200)2.60146754
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60146754
80cell proliferation in forebrain (GO:0021846)2.59150173
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58388791
82glutamate receptor signaling pathway (GO:0007215)2.58319985
83female gonad development (GO:0008585)2.57085564
84peptidyl-lysine trimethylation (GO:0018023)2.56866366
85positive regulation of fibroblast migration (GO:0010763)2.56045613
86intraciliary transport (GO:0042073)2.54361344
87positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.54091680
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53545975
89positive regulation of interleukin-1 secretion (GO:0050716)2.53168610
90retinal ganglion cell axon guidance (GO:0031290)2.51580600
91ganglion development (GO:0061548)2.50399734
92regulation of hippo signaling (GO:0035330)2.49864940
93nonmotile primary cilium assembly (GO:0035058)2.49396094
94sperm motility (GO:0030317)2.48897350
95pigmentation (GO:0043473)2.48691817
96behavioral response to ethanol (GO:0048149)2.48258003
97cerebellar Purkinje cell differentiation (GO:0021702)2.47354508
98polyol catabolic process (GO:0046174)2.46714124
99regulation of NIK/NF-kappaB signaling (GO:1901222)2.46433396
100regulation of platelet aggregation (GO:0090330)2.45642523
101protein prenylation (GO:0018342)2.45380587
102prenylation (GO:0097354)2.45380587
103prostate gland growth (GO:0060736)2.44438412
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44383759
105somite rostral/caudal axis specification (GO:0032525)2.44275985
106C4-dicarboxylate transport (GO:0015740)2.44254099
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42827379
108epithelial cell differentiation involved in kidney development (GO:0035850)2.42668958
109L-amino acid import (GO:0043092)2.42563441
110dentate gyrus development (GO:0021542)2.41804803
111regulation of cilium movement (GO:0003352)2.41333495
112plasma membrane repair (GO:0001778)2.41072030
113hindbrain development (GO:0030902)2.40561478
114positive regulation of glycolytic process (GO:0045821)2.39373810
115artery development (GO:0060840)2.39113149
116protein K11-linked deubiquitination (GO:0035871)2.38675211
117cilium or flagellum-dependent cell motility (GO:0001539)2.38456583
118sympathetic nervous system development (GO:0048485)2.38329425
119neurofilament cytoskeleton organization (GO:0060052)2.38322091
120microtubule anchoring (GO:0034453)2.38262460
121cilium morphogenesis (GO:0060271)2.38161717
122microglial cell activation (GO:0001774)2.38040272
123detection of light stimulus involved in sensory perception (GO:0050962)2.37540119
124detection of light stimulus involved in visual perception (GO:0050908)2.37540119
125histone H3-K4 methylation (GO:0051568)2.36483434
126regulation of collateral sprouting (GO:0048670)2.36464460
127B cell homeostasis (GO:0001782)2.36160448
128inositol phosphate catabolic process (GO:0071545)2.35715143
129photoreceptor cell development (GO:0042461)2.35555792
130cilium organization (GO:0044782)2.35147969
131neuron fate determination (GO:0048664)2.34944891
132inner ear receptor cell development (GO:0060119)2.34918269
133detection of other organism (GO:0098543)2.33827260
134regulation of hexokinase activity (GO:1903299)2.33446384
135regulation of glucokinase activity (GO:0033131)2.33446384
136heart field specification (GO:0003128)2.33096394
137secondary heart field specification (GO:0003139)2.33096394
138cilium movement (GO:0003341)2.32564018
139presynaptic membrane organization (GO:0097090)2.32447800
140glucocorticoid biosynthetic process (GO:0006704)2.32327572
141nucleus localization (GO:0051647)2.31828355
142cilium assembly (GO:0042384)2.30810007
143negative chemotaxis (GO:0050919)2.30357326
144positive regulation of heat generation (GO:0031652)2.30047350
145regulation of interleukin-1 beta secretion (GO:0050706)2.30001831
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29927891
147regulation of protein glycosylation (GO:0060049)2.28919542
148opioid receptor signaling pathway (GO:0038003)2.28582538
149gamma-aminobutyric acid transport (GO:0015812)2.28191054
150photoreceptor cell maintenance (GO:0045494)2.28059012
151sulfation (GO:0051923)2.27422421
152positive regulation of protein homodimerization activity (GO:0090073)2.27005223
153central nervous system projection neuron axonogenesis (GO:0021952)2.26952039
154regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26052730
155cerebral cortex radially oriented cell migration (GO:0021799)2.24360430
156neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.24159774
157neuronal action potential (GO:0019228)2.22921764
158eye photoreceptor cell development (GO:0042462)2.22830781
159neuron recognition (GO:0008038)2.22590614
160dendritic spine morphogenesis (GO:0060997)2.22510115
161cellular response to ethanol (GO:0071361)2.22504756
162renal tubule morphogenesis (GO:0061333)2.22018047
163DNA integration (GO:0015074)2.21606985
164limb development (GO:0060173)2.21325649
165mesenchymal cell differentiation (GO:0048762)2.21206951
166synaptic vesicle endocytosis (GO:0048488)2.20792910
167limb bud formation (GO:0060174)2.20055452
168cAMP catabolic process (GO:0006198)2.19393099
169negative regulation of homotypic cell-cell adhesion (GO:0034111)2.19361291
170centriole assembly (GO:0098534)2.18502203
171postsynaptic membrane organization (GO:0001941)2.18247408
172microtubule depolymerization (GO:0007019)2.17504957
173specification of organ identity (GO:0010092)2.17497813
174regulation of timing of cell differentiation (GO:0048505)2.16647950
175termination of G-protein coupled receptor signaling pathway (GO:0038032)2.15173664
176inner ear receptor stereocilium organization (GO:0060122)2.14938769
177regulation of glutamate receptor signaling pathway (GO:1900449)2.14758740
178superoxide metabolic process (GO:0006801)2.14597751
179negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.14324438
180cyclic nucleotide catabolic process (GO:0009214)2.13984307
181myeloid leukocyte mediated immunity (GO:0002444)2.13790355
182regulation of sarcomere organization (GO:0060297)2.13695305
183import into cell (GO:0098657)2.13394996
184calcium ion import (GO:0070509)2.10603851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.98958630
2EZH2_22144423_ChIP-Seq_EOC_Human3.01436555
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55675221
4PCGF2_27294783_Chip-Seq_ESCs_Mouse2.49220825
5ZNF274_21170338_ChIP-Seq_K562_Hela2.42014441
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.36642619
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31536435
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.30829292
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.24834715
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.23787532
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18242008
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.09368277
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05980767
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04672515
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03195998
16TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.92123373
17IGF1R_20145208_ChIP-Seq_DFB_Human1.90303830
18NANOG_18555785_Chip-Seq_ESCs_Mouse1.89771134
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.84642197
20EZH2_27294783_Chip-Seq_NPCs_Mouse1.84270904
21EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83919042
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83787400
23E2F1_18555785_Chip-Seq_ESCs_Mouse1.81235442
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80630385
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79669572
26P53_22387025_ChIP-Seq_ESCs_Mouse1.78079782
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77877182
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77156775
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75499773
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.73761126
31TAF15_26573619_Chip-Seq_HEK293_Human1.72972259
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.71892117
33DROSHA_22980978_ChIP-Seq_HELA_Human1.70718100
34* P300_19829295_ChIP-Seq_ESCs_Human1.70665118
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.68940305
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67778014
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67110569
38CMYC_18555785_Chip-Seq_ESCs_Mouse1.65860616
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.64786158
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64305060
41FUS_26573619_Chip-Seq_HEK293_Human1.63455106
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61950430
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60421325
44P300_18555785_Chip-Seq_ESCs_Mouse1.58852492
45BCAT_22108803_ChIP-Seq_LS180_Human1.57922449
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.56888523
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.55688311
48CBP_20019798_ChIP-Seq_JUKART_Human1.54511518
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54511518
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.53839592
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53516308
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51873005
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51864532
54* STAT3_23295773_ChIP-Seq_U87_Human1.51426140
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50549359
56RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50252495
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.50023450
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.49487287
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48566505
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48272115
61PU1_27457419_Chip-Seq_LIVER_Mouse1.47833172
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44683972
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43838178
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43538050
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42310794
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42310794
67ESRRB_18555785_Chip-Seq_ESCs_Mouse1.39889713
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39215168
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38791195
70* TCF4_23295773_ChIP-Seq_U87_Human1.38479918
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.38474954
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38243799
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.37873614
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.37478353
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36913679
76CTCF_18555785_Chip-Seq_ESCs_Mouse1.36880277
77AHR_22903824_ChIP-Seq_MCF-7_Human1.35540541
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.35513055
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35304086
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34711861
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33754250
82AR_21572438_ChIP-Seq_LNCaP_Human1.33425542
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.32861380
84ER_23166858_ChIP-Seq_MCF-7_Human1.31002023
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.30189616
86TCF4_22108803_ChIP-Seq_LS180_Human1.30090878
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29881208
88TP53_16413492_ChIP-PET_HCT116_Human1.28831780
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28313871
90KDM2B_26808549_Chip-Seq_REH_Human1.27868630
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27745249
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27745249
93TP53_18474530_ChIP-ChIP_U2OS_Human1.27088509
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.25261019
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24260295
96* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23861639
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22622385
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.22472083
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22285230
100* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21995754
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20787458
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.20538851
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19696937
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18966818
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.18023707
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17940799
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17738622
108* EWS_26573619_Chip-Seq_HEK293_Human1.17521433
109* AR_25329375_ChIP-Seq_VCAP_Human1.17423485
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17080833
111* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16265097
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13957413
113VDR_22108803_ChIP-Seq_LS180_Human1.13919197
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13909886
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.13452736
116MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12526138
117CDX2_22108803_ChIP-Seq_LS180_Human1.12460164
118NANOG_19829295_ChIP-Seq_ESCs_Human1.12344117
119SOX2_19829295_ChIP-Seq_ESCs_Human1.12344117
120RNF2_27304074_Chip-Seq_NSC_Mouse1.12038585
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.11982597
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11424450
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11277348
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10557985
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09443066
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.09079569
127REST_21632747_ChIP-Seq_MESCs_Mouse1.07808313
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.07788155
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07319136
130* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06340574
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05148205
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04698510
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04698510
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02490693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.61214544
2MP0001188_hyperpigmentation3.99551889
3MP0000015_abnormal_ear_pigmentation3.40091348
4MP0005174_abnormal_tail_pigmentation3.32661310
5MP0002102_abnormal_ear_morphology3.10312458
6MP0000566_synostosis2.71009563
7MP0003787_abnormal_imprinting2.68473052
8MP0008877_abnormal_DNA_methylation2.64184252
9MP0005409_darkened_coat_color2.61450183
10MP0004381_abnormal_hair_follicle2.51507487
11MP0003195_calcinosis2.49955289
12MP0003136_yellow_coat_color2.46740503
13MP0003122_maternal_imprinting2.32069144
14MP0005171_absent_coat_pigmentation2.18706829
15MP0005645_abnormal_hypothalamus_physiol2.07358151
16MP0000383_abnormal_hair_follicle2.06666332
17MP0001486_abnormal_startle_reflex2.05560127
18MP0003183_abnormal_peptide_metabolism2.02789217
19MP0009046_muscle_twitch2.00319364
20MP0004270_analgesia1.96761052
21MP0003890_abnormal_embryonic-extraembry1.96116649
22MP0002735_abnormal_chemical_nociception1.91633716
23MP0003880_abnormal_central_pattern1.90471907
24MP0000427_abnormal_hair_cycle1.88331686
25MP0002277_abnormal_respiratory_mucosa1.86483002
26MP0004885_abnormal_endolymph1.86418623
27MP0001485_abnormal_pinna_reflex1.83390113
28MP0004742_abnormal_vestibular_system1.82977618
29MP0001986_abnormal_taste_sensitivity1.78332092
30MP0005248_abnormal_Harderian_gland1.76236855
31MP0006292_abnormal_olfactory_placode1.68456063
32MP0003646_muscle_fatigue1.67468592
33MP0004859_abnormal_synaptic_plasticity1.66278083
34MP0003011_delayed_dark_adaptation1.66132329
35MP0002822_catalepsy1.65851490
36MP0003045_fibrosis1.49033511
37MP0002095_abnormal_skin_pigmentation1.48963481
38MP0000579_abnormal_nail_morphology1.48587082
39MP0005551_abnormal_eye_electrophysiolog1.48446004
40MP0005377_hearing/vestibular/ear_phenot1.43673523
41MP0003878_abnormal_ear_physiology1.43673523
42MP0004043_abnormal_pH_regulation1.40657570
43MP0003172_abnormal_lysosome_physiology1.40165910
44MP0000371_diluted_coat_color1.37660991
45MP0005187_abnormal_penis_morphology1.36599026
46MP0009745_abnormal_behavioral_response1.35697219
47MP0001968_abnormal_touch/_nociception1.33659429
48MP0001293_anophthalmia1.31807717
49MP0008260_abnormal_autophagy1.30252997
50MP0005257_abnormal_intraocular_pressure1.29840970
51MP0002928_abnormal_bile_duct1.29838284
52MP0002067_abnormal_sensory_capabilities1.29677137
53MP0004145_abnormal_muscle_electrophysio1.27392251
54MP0002751_abnormal_autonomic_nervous1.26481734
55MP0004133_heterotaxia1.26227855
56MP0002572_abnormal_emotion/affect_behav1.22250778
57MP0010678_abnormal_skin_adnexa1.21980134
58MP0010386_abnormal_urinary_bladder1.21067068
59MP0001440_abnormal_grooming_behavior1.20104602
60MP0003941_abnormal_skin_development1.17815876
61MP0005085_abnormal_gallbladder_physiolo1.17330400
62MP0000778_abnormal_nervous_system1.16899985
63MP0005451_abnormal_body_composition1.16827211
64MP0008058_abnormal_DNA_repair1.16456959
65MP0008789_abnormal_olfactory_epithelium1.15237384
66MP0005423_abnormal_somatic_nervous1.15094948
67MP0000631_abnormal_neuroendocrine_gland1.13589161
68MP0004084_abnormal_cardiac_muscle1.12126222
69MP0005386_behavior/neurological_phenoty1.11200149
70MP0004924_abnormal_behavior1.11200149
71MP0004215_abnormal_myocardial_fiber1.10003939
72MP0003635_abnormal_synaptic_transmissio1.06848917
73MP0000026_abnormal_inner_ear1.04653501
74MP0002837_dystrophic_cardiac_calcinosis1.04008136
75MP0001324_abnormal_eye_pigmentation1.03718093
76MP0005379_endocrine/exocrine_gland_phen1.03467761
77MP0005391_vision/eye_phenotype1.03269787
78MP0001502_abnormal_circadian_rhythm1.02911550
79MP0002234_abnormal_pharynx_morphology1.01153164
80MP0002075_abnormal_coat/hair_pigmentati1.00713022
81MP0005410_abnormal_fertilization1.00708268
82MP0005253_abnormal_eye_physiology1.00449077
83MP0003119_abnormal_digestive_system1.00126269
84MP0005075_abnormal_melanosome_morpholog0.99944286
85MP0005646_abnormal_pituitary_gland0.99905345
86MP0002090_abnormal_vision0.99904095
87MP0001501_abnormal_sleep_pattern0.98763605
88MP0003718_maternal_effect0.98719611
89MP0001186_pigmentation_phenotype0.97970708
90MP0002557_abnormal_social/conspecific_i0.96122701
91MP0003868_abnormal_feces_composition0.95937367
92MP0000955_abnormal_spinal_cord0.95248750
93MP0001963_abnormal_hearing_physiology0.95245060
94MP0002736_abnormal_nociception_after0.94893645
95MP0002177_abnormal_outer_ear0.92833666
96MP0002063_abnormal_learning/memory/cond0.91177763
97MP0002909_abnormal_adrenal_gland0.91105391
98MP0002233_abnormal_nose_morphology0.90779618
99MP0003828_pulmonary_edema0.89643300
100MP0001970_abnormal_pain_threshold0.88951096
101MP0000230_abnormal_systemic_arterial0.88580115
102MP0005394_taste/olfaction_phenotype0.88276542
103MP0005499_abnormal_olfactory_system0.88276542
104MP0005670_abnormal_white_adipose0.88158403
105MP0006276_abnormal_autonomic_nervous0.87317272
106MP0004142_abnormal_muscle_tone0.85821148
107MP0003632_abnormal_nervous_system0.85648603
108MP0002229_neurodegeneration0.85165868
109MP0009697_abnormal_copulation0.85111362
110MP0002064_seizures0.84373053
111MP0002734_abnormal_mechanical_nocicepti0.82239428
112MP0006072_abnormal_retinal_apoptosis0.80564430
113MP0003724_increased_susceptibility_to0.79791895
114MP0004085_abnormal_heartbeat0.79306139
115MP0008004_abnormal_stomach_pH0.78976159
116MP0003938_abnormal_ear_development0.78340712
117MP0001756_abnormal_urination0.78144823
118MP0001286_abnormal_eye_development0.77574136
119MP0002168_other_aberrant_phenotype0.76181819
120MP0001984_abnormal_olfaction0.75263835
121MP0000538_abnormal_urinary_bladder0.73322673
122MP0004484_altered_response_of0.72551590
123MP0002184_abnormal_innervation0.72517203
124MP0002638_abnormal_pupillary_reflex0.72374392
125MP0004510_myositis0.71105657
126MP0002876_abnormal_thyroid_physiology0.70657376
127MP0005647_abnormal_sex_gland0.68774172
128MP0002419_abnormal_innate_immunity0.68719849
129MP0002272_abnormal_nervous_system0.68630233
130MP0001346_abnormal_lacrimal_gland0.67647813
131MP0002254_reproductive_system_inflammat0.64441507
132MP0002752_abnormal_somatic_nervous0.63510222
133MP0009764_decreased_sensitivity_to0.62691413
134MP0000470_abnormal_stomach_morphology0.58293043
135MP0005195_abnormal_posterior_eye0.57856733
136MP0003283_abnormal_digestive_organ0.56026348
137MP0009780_abnormal_chondrocyte_physiolo0.55693188
138MP0000462_abnormal_digestive_system0.55434092
139MP0000647_abnormal_sebaceous_gland0.54936577
140MP0001661_extended_life_span0.54543080
141MP0000372_irregular_coat_pigmentation0.54132640
142MP0002396_abnormal_hematopoietic_system0.53949843
143MP0002882_abnormal_neuron_morphology0.53761148
144MP0003879_abnormal_hair_cell0.53626613
145MP0002938_white_spotting0.51825920
146MP0001790_abnormal_immune_system0.51393029
147MP0005387_immune_system_phenotype0.51393029
148MP0003121_genomic_imprinting0.49644240

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.02096534
2Chromsome breakage (HP:0040012)5.32465682
3Febrile seizures (HP:0002373)4.91243421
4Prostate neoplasm (HP:0100787)4.42560231
5Hyperventilation (HP:0002883)3.96854194
6Hepatoblastoma (HP:0002884)3.46683507
7Pancreatic cysts (HP:0001737)3.39294537
8Duplicated collecting system (HP:0000081)3.31581297
9Congenital stationary night blindness (HP:0007642)3.27411221
10Pancreatic fibrosis (HP:0100732)3.15807780
11Abnormality of the renal collecting system (HP:0004742)3.09387482
12Intestinal atresia (HP:0011100)2.96516049
13Papillary thyroid carcinoma (HP:0002895)2.94883305
14Neoplasm of the adrenal cortex (HP:0100641)2.91857402
15Generalized hypopigmentation of hair (HP:0011358)2.90254727
16True hermaphroditism (HP:0010459)2.89668699
17Protruding tongue (HP:0010808)2.89650696
18Abnormality of DNA repair (HP:0003254)2.79783928
19Absent speech (HP:0001344)2.78182184
20Molar tooth sign on MRI (HP:0002419)2.73453593
21Abnormality of midbrain morphology (HP:0002418)2.73453593
22Fair hair (HP:0002286)2.72233457
23Focal motor seizures (HP:0011153)2.72061847
24Medial flaring of the eyebrow (HP:0010747)2.71371544
25Tubular atrophy (HP:0000092)2.69123036
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.67811772
27Absent/shortened dynein arms (HP:0200106)2.67811772
28Colon cancer (HP:0003003)2.67502251
29Submucous cleft hard palate (HP:0000176)2.55257481
30Congenital sensorineural hearing impairment (HP:0008527)2.53870694
31Tubulointerstitial nephritis (HP:0001970)2.52574606
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.45203856
33Optic nerve hypoplasia (HP:0000609)2.39417945
34Gingivitis (HP:0000230)2.39062968
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37902375
36Abnormality of the nasal septum (HP:0000419)2.36934731
37Ectopic kidney (HP:0000086)2.36206309
38Abnormality of incisor morphology (HP:0011063)2.35802740
39Abnormality of the labia minora (HP:0012880)2.35413302
40Calf muscle hypertrophy (HP:0008981)2.35409219
41Gait imbalance (HP:0002141)2.35327586
42Genital tract atresia (HP:0001827)2.33656633
43Decreased central vision (HP:0007663)2.32790827
44Anal stenosis (HP:0002025)2.31496961
45Clubbing of toes (HP:0100760)2.29936451
46Excessive salivation (HP:0003781)2.29336455
47Drooling (HP:0002307)2.29336455
48Vaginal atresia (HP:0000148)2.26853645
49Aplasia cutis congenita (HP:0001057)2.26714802
50Absent frontal sinuses (HP:0002688)2.25105866
51Aqueductal stenosis (HP:0002410)2.24008133
52Congenital primary aphakia (HP:0007707)2.22517014
53Abnormal ciliary motility (HP:0012262)2.19468922
54Abolished electroretinogram (ERG) (HP:0000550)2.19367644
55Tetany (HP:0001281)2.17720573
56Exotropia (HP:0000577)2.16803467
57Labial hypoplasia (HP:0000066)2.16495379
58Abnormality of the preputium (HP:0100587)2.16130869
59Attenuation of retinal blood vessels (HP:0007843)2.16041025
60Volvulus (HP:0002580)2.15812063
61Inability to walk (HP:0002540)2.15404320
62Abnormal drinking behavior (HP:0030082)2.14463662
63Polydipsia (HP:0001959)2.14463662
64Premature loss of primary teeth (HP:0006323)2.14000383
65Muscle hypertrophy of the lower extremities (HP:0008968)2.13953647
66Recurrent abscess formation (HP:0002722)2.11474714
67Epidermoid cyst (HP:0200040)2.10986965
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10841026
69Poor coordination (HP:0002370)2.10524482
70Chronic hepatic failure (HP:0100626)2.09939325
71Lip pit (HP:0100267)2.09592176
72Thyroid carcinoma (HP:0002890)2.09396338
73Mesomelia (HP:0003027)2.08400490
74Meckel diverticulum (HP:0002245)2.07946570
75Hip dysplasia (HP:0001385)2.06272992
76Tubulointerstitial abnormality (HP:0001969)2.04728768
77Abnormality of chromosome stability (HP:0003220)2.04390557
78Chorioretinal atrophy (HP:0000533)2.02055615
79Chronic mucocutaneous candidiasis (HP:0002728)1.99589114
80Recurrent cutaneous fungal infections (HP:0011370)1.99589114
81Abnormality of the carotid arteries (HP:0005344)1.99288526
82Polyphagia (HP:0002591)1.99252748
83Abnormality of the ileum (HP:0001549)1.98835276
84Microvesicular hepatic steatosis (HP:0001414)1.98756275
85Atonic seizures (HP:0010819)1.97803766
86Cupped ear (HP:0000378)1.97395573
87Congenital hepatic fibrosis (HP:0002612)1.96800600
88Abnormality of the prostate (HP:0008775)1.96765899
89Blue irides (HP:0000635)1.95261396
90Retrobulbar optic neuritis (HP:0100654)1.95070156
91Optic neuritis (HP:0100653)1.95070156
92Recurrent bacterial skin infections (HP:0005406)1.94651315
93Widely spaced teeth (HP:0000687)1.94215169
94Nephrogenic diabetes insipidus (HP:0009806)1.94205477
95Tubulointerstitial fibrosis (HP:0005576)1.92921987
96Abnormality of the columella (HP:0009929)1.92917544
97Abnormality of salivation (HP:0100755)1.92346096
98Periodontitis (HP:0000704)1.91584006
99Abnormality of the renal medulla (HP:0100957)1.90527421
100Septo-optic dysplasia (HP:0100842)1.90267976
101Aplasia/Hypoplasia of the macula (HP:0008059)1.90223203
102Abnormal rod and cone electroretinograms (HP:0008323)1.88798069
103Decreased circulating renin level (HP:0003351)1.88777266
104Growth hormone deficiency (HP:0000824)1.88765235
105Renal cortical cysts (HP:0000803)1.88751916
106Gastrointestinal atresia (HP:0002589)1.88116772
107Hypoplastic labia majora (HP:0000059)1.87388042
108Nephronophthisis (HP:0000090)1.87344810
109Dialeptic seizures (HP:0011146)1.87108940
110Polyuria (HP:0000103)1.86708022
111Gaze-evoked nystagmus (HP:0000640)1.86533702
112Dyschromatopsia (HP:0007641)1.86435372
113Bony spicule pigmentary retinopathy (HP:0007737)1.86221692
114Progressive inability to walk (HP:0002505)1.84944940
115Anencephaly (HP:0002323)1.84120809
116Abnormal respiratory motile cilium physiology (HP:0012261)1.83907818
117Osteomalacia (HP:0002749)1.83809162
118Progressive cerebellar ataxia (HP:0002073)1.83150045
119Hypomagnesemia (HP:0002917)1.82471511
120Hypoplastic female external genitalia (HP:0012815)1.79682564
121Postaxial hand polydactyly (HP:0001162)1.79162690
122Abnormality of the fingertips (HP:0001211)1.79094639
123Hypothermia (HP:0002045)1.78591556
124Abnormality of macular pigmentation (HP:0008002)1.77927350
125Thyroiditis (HP:0100646)1.77700595
126Abnormality of the labia majora (HP:0012881)1.76714423
127Broad-based gait (HP:0002136)1.76588596
128Abnormality of primary teeth (HP:0006481)1.75958900
129Duplication of thumb phalanx (HP:0009942)1.74951481
130Epileptic encephalopathy (HP:0200134)1.73931118
131Hypoplastic iliac wings (HP:0002866)1.73362403
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.73165545
133Alveolar cell carcinoma (HP:0006519)1.73023791
134Pulmonary artery stenosis (HP:0004415)1.72930683
135Cystic liver disease (HP:0006706)1.71847822
136Pachygyria (HP:0001302)1.70877982
137Hyperglycinemia (HP:0002154)1.70817979
138Stomach cancer (HP:0012126)1.70264532
139Focal seizures (HP:0007359)1.69836405
140Urethral obstruction (HP:0000796)1.69600858
141Anophthalmia (HP:0000528)1.68506745
142Renal hypoplasia (HP:0000089)1.68416072
143Disproportionate short-trunk short stature (HP:0003521)1.67778580
144Abnormality of the ischium (HP:0003174)1.67441625
145Narrow forehead (HP:0000341)1.67276925
146Pendular nystagmus (HP:0012043)1.66354463
147Specific learning disability (HP:0001328)1.65744094
148Nephroblastoma (Wilms tumor) (HP:0002667)1.64994022
149White forelock (HP:0002211)1.64727154
150Oligodactyly (hands) (HP:0001180)1.64484630
151Abnormal hair whorl (HP:0010721)1.64408399
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.64087491
153Ocular albinism (HP:0001107)1.63901824
154Hypoplastic ischia (HP:0003175)1.62762776
155Thick nail (HP:0001805)1.62596053
156Keratoconus (HP:0000563)1.61335911
157Increased corneal curvature (HP:0100692)1.61335911
158Progressive hearing impairment (HP:0001730)1.60394515
159Abnormality of the renal cortex (HP:0011035)1.60259200
160Generalized hypopigmentation (HP:0007513)1.58657868
161Bell-shaped thorax (HP:0001591)1.58460925
162Abnormality of the frontal sinuses (HP:0002687)1.58098137
163Stomatitis (HP:0010280)1.57643210
164Neoplasm of the tracheobronchial system (HP:0100552)1.56453053
165Ectropion (HP:0000656)1.54727175
166Abnormality of the right ventricle (HP:0001707)1.54153027
167Abnormal respiratory epithelium morphology (HP:0012253)1.53881440
168Abnormal respiratory motile cilium morphology (HP:0005938)1.53881440
169Midline defect of the nose (HP:0004122)1.53695373
170Aplasia/Hypoplasia of the earlobes (HP:0009906)1.53275075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.78917641
2TNIK3.24662900
3INSRR3.22525708
4ACVR1B2.89082761
5EIF2AK22.71750228
6NTRK32.53422084
7BRD42.37954921
8CAMK1G2.30386655
9CAMK1D2.24650276
10IRAK32.18891523
11ZAK2.14333084
12MAP3K142.03303871
13SIK21.95860145
14TAOK31.91179004
15GRK11.86931248
16PINK11.86607958
17MAP4K21.84980606
18RIPK41.83174390
19STK38L1.73835559
20BCR1.71308361
21SGK21.68750670
22TXK1.59419437
23OXSR11.56710984
24PRPF4B1.55587671
25FRK1.46963341
26MAP3K131.46265564
27YES11.45555169
28PAK31.45106698
29CDK121.45040011
30IRAK41.41984295
31OBSCN1.40248235
32EPHA41.38521890
33LATS11.35327721
34AKT31.33318325
35MAP2K71.32566290
36STK391.28103787
37NUAK11.25314547
38PKN11.24056805
39ADRBK21.24011562
40TRIM281.20941350
41DYRK21.17932819
42NLK1.17569921
43JAK11.16164848
44NEK61.14472293
45SGK11.12344584
46MKNK21.08567424
47CSNK1G21.06031440
48TIE11.05040279
49SGK31.04007815
50CSNK1G11.01039032
51MAPK131.00888045
52CDK31.00483059
53BMPR20.97713202
54EPHA30.94494894
55EPHB20.94332324
56SGK2230.93791281
57SGK4940.93791281
58STK160.93514074
59MARK10.93441429
60PIK3CA0.91656874
61TGFBR10.91619100
62FES0.90910106
63DAPK20.88865557
64FGR0.88496183
65SRPK10.87654827
66IKBKE0.83417998
67PRKAA20.82964867
68FER0.82680668
69PLK20.81386374
70NTRK20.81291876
71DYRK30.78089511
72MAPK70.77622245
73PIK3CG0.75725853
74PRKCE0.74163985
75CAMK40.71816332
76WNK40.71302112
77KIT0.70837692
78CSNK1A1L0.70312957
79MAP3K20.70053795
80GRK70.69242127
81STK240.68117049
82SIK30.67783062
83HCK0.67296796
84MKNK10.67233656
85MAP3K40.66963236
86ADRBK10.66750764
87TAF10.66683641
88ERBB20.65912977
89CDC42BPA0.65855891
90CAMK10.65685422
91CSNK1G30.65563346
92BMPR1B0.65461101
93TGFBR20.65182951
94WNK10.65151444
95TEC0.65079732
96PTK2B0.64495502
97DYRK1A0.63407571
98BLK0.62963267
99KSR10.61974417
100MARK20.61354147
101PHKG10.60895818
102PHKG20.60895818
103PRKCZ0.60630806
104MAP2K40.60497799
105PRKG10.56038068
106PRKACB0.55562920
107IKBKB0.55340419
108IRAK10.54978873
109STK110.54407171
110TNK20.54085858
111PLK40.51962395
112MAP3K60.51935088
113MUSK0.50944895
114CDK190.50711370
115CAMK2A0.50238300
116ATR0.50188414
117IRAK20.49733251
118FGFR10.48755155
119STK380.47839184
120CHUK0.46089891
121TRPM70.44474919
122PRKACA0.44422954
123FGFR20.44275787
124MAPK100.44127000
125PLK30.43975944
126WNK30.43850788
127ERBB30.43232942
128CSNK1D0.42199672
129MAPK120.39822379
130LYN0.39739483
131PNCK0.39463609
132MAP3K70.38953557
133STK30.38743698
134MST40.37953829
135ATM0.37839354
136SIK10.37519926
137PRKCG0.37383623
138CAMK2D0.37243788
139JAK30.36940708
140PRKCB0.35186006
141CDK90.35130133
142CAMK2B0.35022138
143CHEK20.34901393
144PRKAA10.34572834
145CAMKK20.34559995

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.92013396
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42955201
3Phototransduction_Homo sapiens_hsa047442.34954907
4Butanoate metabolism_Homo sapiens_hsa006502.11540560
5Linoleic acid metabolism_Homo sapiens_hsa005911.99724451
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96031047
7Fanconi anemia pathway_Homo sapiens_hsa034601.95671726
8Taste transduction_Homo sapiens_hsa047421.90502965
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.89266705
10Morphine addiction_Homo sapiens_hsa050321.87163435
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82342937
12Fatty acid biosynthesis_Homo sapiens_hsa000611.79539669
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67494274
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62767230
15Nitrogen metabolism_Homo sapiens_hsa009101.61942309
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.60553732
17Type II diabetes mellitus_Homo sapiens_hsa049301.59925929
18Glutamatergic synapse_Homo sapiens_hsa047241.55160315
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53064034
20Tryptophan metabolism_Homo sapiens_hsa003801.49895227
21Propanoate metabolism_Homo sapiens_hsa006401.49714020
22Lysine degradation_Homo sapiens_hsa003101.48368374
23ABC transporters_Homo sapiens_hsa020101.48356685
24Calcium signaling pathway_Homo sapiens_hsa040201.41085980
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.41085261
26Retinol metabolism_Homo sapiens_hsa008301.40744577
27Selenocompound metabolism_Homo sapiens_hsa004501.34589112
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32969215
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31688655
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31114279
31Olfactory transduction_Homo sapiens_hsa047401.27230524
32Inositol phosphate metabolism_Homo sapiens_hsa005621.23264531
33Serotonergic synapse_Homo sapiens_hsa047261.22243882
34Circadian entrainment_Homo sapiens_hsa047131.22029016
35Fatty acid degradation_Homo sapiens_hsa000711.21977393
36Non-homologous end-joining_Homo sapiens_hsa034501.20119053
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20096662
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19414233
39Sphingolipid metabolism_Homo sapiens_hsa006001.16829025
40Regulation of autophagy_Homo sapiens_hsa041401.12012766
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10689762
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09828250
43Insulin secretion_Homo sapiens_hsa049111.07335104
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06646668
45Cardiac muscle contraction_Homo sapiens_hsa042601.06538940
46Chemical carcinogenesis_Homo sapiens_hsa052041.06203456
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05891001
48Salivary secretion_Homo sapiens_hsa049701.05024545
49cAMP signaling pathway_Homo sapiens_hsa040241.02012641
50Vitamin digestion and absorption_Homo sapiens_hsa049771.01653281
51Axon guidance_Homo sapiens_hsa043601.01020578
52Histidine metabolism_Homo sapiens_hsa003401.00663426
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99997570
54Hematopoietic cell lineage_Homo sapiens_hsa046400.97787719
55Osteoclast differentiation_Homo sapiens_hsa043800.97262497
56Amphetamine addiction_Homo sapiens_hsa050310.96861739
57Peroxisome_Homo sapiens_hsa041460.96685974
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94778008
59Protein export_Homo sapiens_hsa030600.93818170
60Renin secretion_Homo sapiens_hsa049240.93348696
61Cholinergic synapse_Homo sapiens_hsa047250.93234101
62Ovarian steroidogenesis_Homo sapiens_hsa049130.92925943
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91683414
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90595881
65Rheumatoid arthritis_Homo sapiens_hsa053230.89140802
66GABAergic synapse_Homo sapiens_hsa047270.88598591
67Collecting duct acid secretion_Homo sapiens_hsa049660.88380939
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88307324
69African trypanosomiasis_Homo sapiens_hsa051430.88117362
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86208968
71Measles_Homo sapiens_hsa051620.86170346
72Starch and sucrose metabolism_Homo sapiens_hsa005000.86162409
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.86111198
74Oxidative phosphorylation_Homo sapiens_hsa001900.86016754
75Dorso-ventral axis formation_Homo sapiens_hsa043200.84512764
76Pancreatic secretion_Homo sapiens_hsa049720.84322092
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83353321
78Glycerolipid metabolism_Homo sapiens_hsa005610.83159373
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82817301
80Basal transcription factors_Homo sapiens_hsa030220.82391399
81beta-Alanine metabolism_Homo sapiens_hsa004100.82167505
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81116561
83Malaria_Homo sapiens_hsa051440.80446539
84Graft-versus-host disease_Homo sapiens_hsa053320.79387195
85Arachidonic acid metabolism_Homo sapiens_hsa005900.79320359
86Chemokine signaling pathway_Homo sapiens_hsa040620.79254087
87TNF signaling pathway_Homo sapiens_hsa046680.78629866
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78461451
89Hedgehog signaling pathway_Homo sapiens_hsa043400.78355999
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75678839
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.75418329
92Bile secretion_Homo sapiens_hsa049760.75216860
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73863434
94ErbB signaling pathway_Homo sapiens_hsa040120.73835808
95Phagosome_Homo sapiens_hsa041450.73435266
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72847764
97Choline metabolism in cancer_Homo sapiens_hsa052310.72361153
98Long-term potentiation_Homo sapiens_hsa047200.72113958
99Synaptic vesicle cycle_Homo sapiens_hsa047210.70437176
100Influenza A_Homo sapiens_hsa051640.70244269
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70013193
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68835647
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67908637
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67777827
105Autoimmune thyroid disease_Homo sapiens_hsa053200.67482058
106Long-term depression_Homo sapiens_hsa047300.67209506
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.66983994
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66684426
109Circadian rhythm_Homo sapiens_hsa047100.66645940
110Ras signaling pathway_Homo sapiens_hsa040140.66570845
111Dopaminergic synapse_Homo sapiens_hsa047280.66564149
112Fatty acid metabolism_Homo sapiens_hsa012120.65963568
113TGF-beta signaling pathway_Homo sapiens_hsa043500.65860204
114Tuberculosis_Homo sapiens_hsa051520.65842056
115Caffeine metabolism_Homo sapiens_hsa002320.65312257
116Oxytocin signaling pathway_Homo sapiens_hsa049210.64471361
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63907149
118Tight junction_Homo sapiens_hsa045300.63589135
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62858143
120Fat digestion and absorption_Homo sapiens_hsa049750.61919287
121Asthma_Homo sapiens_hsa053100.61809156
122Cocaine addiction_Homo sapiens_hsa050300.61618378
123Ether lipid metabolism_Homo sapiens_hsa005650.61157443
124Staphylococcus aureus infection_Homo sapiens_hsa051500.61099988
125Basal cell carcinoma_Homo sapiens_hsa052170.60933029
126Mineral absorption_Homo sapiens_hsa049780.59906613
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.59807230
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59446363
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58782716
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.58633239
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57998602
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56740490
133Melanoma_Homo sapiens_hsa052180.56444487
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56119921
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.55708413
136Dilated cardiomyopathy_Homo sapiens_hsa054140.55557912
137Steroid biosynthesis_Homo sapiens_hsa001000.55415101
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54579665
139ECM-receptor interaction_Homo sapiens_hsa045120.53601542
140MAPK signaling pathway_Homo sapiens_hsa040100.53324709
141PPAR signaling pathway_Homo sapiens_hsa033200.52666250
142FoxO signaling pathway_Homo sapiens_hsa040680.52592571
143Hepatitis C_Homo sapiens_hsa051600.52566698
144Allograft rejection_Homo sapiens_hsa053300.52227276
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.51814241
146Gastric acid secretion_Homo sapiens_hsa049710.51619895
147B cell receptor signaling pathway_Homo sapiens_hsa046620.50302592
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49906226
149Hippo signaling pathway_Homo sapiens_hsa043900.48462817
150Alzheimers disease_Homo sapiens_hsa050100.45377244
151Gap junction_Homo sapiens_hsa045400.43861064

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