FGD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.55772957
2regulation of interferon-beta biosynthetic process (GO:0045357)6.19442984
3B cell receptor signaling pathway (GO:0050853)5.87945981
4positive regulation of B cell differentiation (GO:0045579)5.87090384
5antigen processing and presentation of endogenous antigen (GO:0019883)5.50219203
6regulation of B cell differentiation (GO:0045577)5.46779777
7immunoglobulin mediated immune response (GO:0016064)5.03439435
8positive regulation of gamma-delta T cell activation (GO:0046645)5.02011108
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01042742
10macrophage activation involved in immune response (GO:0002281)4.92555088
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.86491317
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.86491317
13modulation by symbiont of host immune response (GO:0052553)4.86491317
14positive regulation by symbiont of host defense response (GO:0052509)4.86491317
15modulation by symbiont of host defense response (GO:0052031)4.86491317
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.86491317
17microglial cell activation (GO:0001774)4.85664533
18negative regulation of granulocyte differentiation (GO:0030853)4.74403222
19detection of other organism (GO:0098543)4.69410244
20detection of bacterium (GO:0016045)4.58044012
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55350990
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55350990
23G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.43785604
24positive regulation of interferon-alpha production (GO:0032727)4.33153270
25negative regulation of interleukin-12 production (GO:0032695)4.27125313
26mature B cell differentiation (GO:0002335)4.20539119
27respiratory burst (GO:0045730)4.11185511
28regulation of interferon-alpha production (GO:0032647)4.06960339
29positive regulation of antigen processing and presentation (GO:0002579)4.02584482
30negative regulation of bone resorption (GO:0045779)3.96929660
31negative regulation of B cell proliferation (GO:0030889)3.90628770
32detection of external biotic stimulus (GO:0098581)3.86915635
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.86160350
34cellular extravasation (GO:0045123)3.85412743
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80623402
36positive regulation of chemokine secretion (GO:0090197)3.79693712
37macrophage activation (GO:0042116)3.72543882
38germinal center formation (GO:0002467)3.66326813
39response to muramyl dipeptide (GO:0032495)3.65119071
40positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.64938798
41defense response to protozoan (GO:0042832)3.57917653
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.57810711
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.56691894
44negative regulation of T cell mediated immunity (GO:0002710)3.56629616
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56205247
46positive regulation of type 2 immune response (GO:0002830)3.55652340
47negative thymic T cell selection (GO:0045060)3.54358776
48negative regulation of phagocytosis (GO:0050765)3.53530086
49neutrophil activation involved in immune response (GO:0002283)3.52206737
50detection of molecule of bacterial origin (GO:0032490)3.51821122
51myeloid cell activation involved in immune response (GO:0002275)3.51555115
52mature B cell differentiation involved in immune response (GO:0002313)3.51473144
53B cell mediated immunity (GO:0019724)3.51132535
54I-kappaB phosphorylation (GO:0007252)3.51097996
55interferon-gamma-mediated signaling pathway (GO:0060333)3.47745333
56detection of biotic stimulus (GO:0009595)3.45036168
57positive regulation of interferon-beta production (GO:0032728)3.44086414
58regulation of gamma-delta T cell differentiation (GO:0045586)3.43551894
59G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.42478012
60B cell homeostasis (GO:0001782)3.41562059
61negative T cell selection (GO:0043383)3.36946273
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36445944
63response to peptidoglycan (GO:0032494)3.35982979
64regulation of T cell tolerance induction (GO:0002664)3.34541029
65regulation of gamma-delta T cell activation (GO:0046643)3.34427410
66production of molecular mediator involved in inflammatory response (GO:0002532)3.34328640
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.34007084
68regulation of antigen processing and presentation (GO:0002577)3.33788136
69cellular response to exogenous dsRNA (GO:0071360)3.32591561
70pinocytosis (GO:0006907)3.30944154
71leukocyte aggregation (GO:0070486)3.29789004
72mast cell activation (GO:0045576)3.29477701
73positive regulation of mast cell activation involved in immune response (GO:0033008)3.27923586
74positive regulation of mast cell degranulation (GO:0043306)3.27923586
75regulation of mast cell degranulation (GO:0043304)3.25412414
76response to protozoan (GO:0001562)3.22287380
77positive thymic T cell selection (GO:0045059)3.21524172
78neutrophil activation (GO:0042119)3.20605152
79negative regulation of cell killing (GO:0031342)3.20310108
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20310108
81regulation of tolerance induction (GO:0002643)3.20220030
82positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.19505692
83negative regulation of leukocyte mediated immunity (GO:0002704)3.18974535
84negative regulation of tissue remodeling (GO:0034104)3.17123705
85regulation of B cell proliferation (GO:0030888)3.15782009
86antigen processing and presentation via MHC class Ib (GO:0002475)3.15401245
87T cell selection (GO:0045058)3.14121324
88response to host (GO:0075136)3.13827414
89negative regulation of interleukin-6 production (GO:0032715)3.12854426
90T cell migration (GO:0072678)3.12437392
91activated T cell proliferation (GO:0050798)3.11622058
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.11349110
93regulation of mast cell activation involved in immune response (GO:0033006)3.09126539
94myeloid dendritic cell activation (GO:0001773)3.08185877
95tolerance induction (GO:0002507)3.07599982
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05781912
97negative regulation of bone remodeling (GO:0046851)3.05410643
98response to type I interferon (GO:0034340)3.05055398
99cellular response to zinc ion (GO:0071294)3.04464257
100type I interferon signaling pathway (GO:0060337)3.04147746
101cellular response to type I interferon (GO:0071357)3.04147746
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04121084
103regulation of leukocyte degranulation (GO:0043300)3.03332098
104positive T cell selection (GO:0043368)3.03124402
105mannose metabolic process (GO:0006013)3.02773229
106B cell proliferation (GO:0042100)3.02673216
107macrophage differentiation (GO:0030225)3.01386621
108regulation of mast cell activation (GO:0033003)3.00268934
109response to host immune response (GO:0052572)2.99695441
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99695441
111regulation of granulocyte differentiation (GO:0030852)2.99114011
112T-helper 1 type immune response (GO:0042088)2.97130243
113myeloid leukocyte activation (GO:0002274)2.96965328
114purinergic nucleotide receptor signaling pathway (GO:0035590)2.96732650
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96636389
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96379411
117cellular response to interferon-gamma (GO:0071346)2.96222508
118regulation of alpha-beta T cell proliferation (GO:0046640)2.93753284
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93744260
120regulation of B cell apoptotic process (GO:0002902)2.93534872
121positive regulation of mast cell activation (GO:0033005)2.91812087
122adaptation of signaling pathway (GO:0023058)2.90822030
123lymphocyte homeostasis (GO:0002260)2.89559376
124antigen receptor-mediated signaling pathway (GO:0050851)2.89255045
125granulocyte activation (GO:0036230)2.88705143
126regulation of hypersensitivity (GO:0002883)2.88632786
127regulation of T-helper 1 cell differentiation (GO:0045625)2.88468397
128regulation of T-helper 2 cell differentiation (GO:0045628)2.87158342
129natural killer cell differentiation (GO:0001779)2.86622996
130regulation of type 2 immune response (GO:0002828)2.85253954
131positive regulation of B cell activation (GO:0050871)2.85226871
132leukocyte degranulation (GO:0043299)2.82286515
133regulation of interferon-gamma biosynthetic process (GO:0045072)2.82048425
134positive regulation of interleukin-12 production (GO:0032735)2.81799515
135cellular response to interferon-beta (GO:0035458)2.81306528
136response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80109837
137response to host defenses (GO:0052200)2.80109837
138regulation of interleukin-12 production (GO:0032655)2.79833705
139neutrophil mediated immunity (GO:0002446)2.79238066
140positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78916062
141regulation of germinal center formation (GO:0002634)2.78221552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.10809108
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.09813655
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.07416381
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85696618
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.82853736
6SCL_19346495_ChIP-Seq_HPC-7_Human3.72206943
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58040711
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.52872969
9MYC_22102868_ChIP-Seq_BL_Human3.29044680
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27105929
11VDR_21846776_ChIP-Seq_THP-1_Human3.15842799
12GATA1_22025678_ChIP-Seq_K562_Human3.09832518
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08545735
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08231274
15EGR1_19374776_ChIP-ChIP_THP-1_Human3.06392456
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.75829398
17* SPI1_23547873_ChIP-Seq_NB4_Human2.65266981
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56259361
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52496635
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.49333706
21* VDR_24763502_ChIP-Seq_THP-1_Human2.46687662
22RUNX_20019798_ChIP-Seq_JUKART_Human2.44760723
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43919767
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42394149
25* SPI1_23127762_ChIP-Seq_K562_Human2.42234949
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35921512
27MYB_26560356_Chip-Seq_TH2_Human2.28233912
28MAF_26560356_Chip-Seq_TH1_Human2.26581979
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26228661
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20436696
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17112728
32MYB_26560356_Chip-Seq_TH1_Human2.16654971
33E2F7_22180533_ChIP-Seq_HELA_Human2.15334302
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.13661655
35TCF7_22412390_ChIP-Seq_EML_Mouse2.04520612
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02067468
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01291427
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00571631
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91215253
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90612173
41UTX_26944678_Chip-Seq_JUKART_Human1.88804426
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83239847
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77614997
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75195948
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69819437
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.68258158
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67258599
48CIITA_25753668_ChIP-Seq_RAJI_Human1.60672886
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59078179
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56650349
51* PU_27001747_Chip-Seq_BMDM_Mouse1.56570172
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55680577
53GATA3_27048872_Chip-Seq_THYMUS_Human1.55429567
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.51671771
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48568132
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47740285
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44903818
58* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41730049
59KDM2B_26808549_Chip-Seq_DND41_Human1.40290583
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34150565
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31688457
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.31658148
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30924895
64MAF_26560356_Chip-Seq_TH2_Human1.28552313
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27865153
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27726265
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26577106
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26088181
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22501544
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22434835
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22317454
72* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22303520
73GATA3_26560356_Chip-Seq_TH2_Human1.19066426
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18872243
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17856041
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.13554676
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13432170
78BCL6_27268052_Chip-Seq_Bcells_Human1.10744311
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10632900
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06570139
81SMRT_27268052_Chip-Seq_Bcells_Human1.05430080
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03487263
83VDR_24787735_ChIP-Seq_THP-1_Human1.03056749
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00952985
85* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99950098
86FOXM1_23109430_ChIP-Seq_U2OS_Human0.99906852
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99615465
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.95041092
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93737391
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92616485
91BCOR_27268052_Chip-Seq_Bcells_Human0.91079563
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90785647
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89498941
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88590993
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87934897
96LXR_22292898_ChIP-Seq_THP-1_Human0.87599532
97SPI1_20517297_ChIP-Seq_HL60_Human0.87000767
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85830338
99GATA1_19941826_ChIP-Seq_K562_Human0.85269187
100STAT1_20625510_ChIP-Seq_HELA_Human0.82874696
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81961460
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80719573
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80299190
104P300_27268052_Chip-Seq_Bcells_Human0.78277779
105* GATA2_19941826_ChIP-Seq_K562_Human0.78123869
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.76518974
107* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75913138
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73175950
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72908166
110TFEB_21752829_ChIP-Seq_HELA_Human0.72871399
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71613493
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71444380
113* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69524739
114GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68866344
115NCOR1_26117541_ChIP-Seq_K562_Human0.68638221
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68525528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.38786135
2MP0001800_abnormal_humoral_immune3.47754170
3MP0005387_immune_system_phenotype3.35782254
4MP0001790_abnormal_immune_system3.35782254
5MP0005671_abnormal_response_to3.32553466
6MP0002452_abnormal_antigen_presenting3.12559224
7MP0003303_peritoneal_inflammation3.06071554
8MP0000685_abnormal_immune_system3.02694968
9MP0005000_abnormal_immune_tolerance2.86586262
10MP0005058_abnormal_lysosome_morphology2.82699151
11MP0002723_abnormal_immune_serum2.79867891
12MP0002419_abnormal_innate_immunity2.73684297
13MP0002420_abnormal_adaptive_immunity2.67711294
14MP0005464_abnormal_platelet_physiology2.65930455
15MP0001819_abnormal_immune_cell2.65907749
16MP0002396_abnormal_hematopoietic_system2.65695044
17MP0003436_decreased_susceptibility_to2.51200535
18MP0003191_abnormal_cellular_cholesterol2.43634641
19MP0005025_abnormal_response_to2.43369082
20MP0002148_abnormal_hypersensitivity_rea2.43300591
21MP0003183_abnormal_peptide_metabolism2.31509788
22MP0002398_abnormal_bone_marrow2.28749936
23MP0003172_abnormal_lysosome_physiology2.23623991
24MP0000716_abnormal_immune_system2.20194973
25MP0006082_CNS_inflammation2.13439092
26MP0003300_gastrointestinal_ulcer2.12268125
27MP0009785_altered_susceptibility_to2.09387256
28MP0000689_abnormal_spleen_morphology2.08442068
29MP0001853_heart_inflammation1.99526496
30MP0002405_respiratory_system_inflammati1.87335919
31MP0002429_abnormal_blood_cell1.81357539
32MP0002722_abnormal_immune_system1.79391832
33MP0001845_abnormal_inflammatory_respons1.78580825
34MP0002166_altered_tumor_susceptibility1.76749447
35MP0004808_abnormal_hematopoietic_stem1.73259341
36MP0000465_gastrointestinal_hemorrhage1.69950187
37MP0001873_stomach_inflammation1.69192862
38MP0003763_abnormal_thymus_physiology1.66356694
39MP0009333_abnormal_splenocyte_physiolog1.61960495
40MP0004510_myositis1.58045999
41MP0010155_abnormal_intestine_physiology1.55940218
42MP0005174_abnormal_tail_pigmentation1.53235359
43MP0002928_abnormal_bile_duct1.53091674
44MP0005310_abnormal_salivary_gland1.51636705
45MP0000569_abnormal_digit_pigmentation1.49582649
46MP0008469_abnormal_protein_level1.48488635
47MP0000015_abnormal_ear_pigmentation1.42832684
48MP0003866_abnormal_defecation1.41921347
49MP0009278_abnormal_bone_marrow1.29327283
50MP0000703_abnormal_thymus_morphology1.28091522
51MP0001533_abnormal_skeleton_physiology1.25901232
52MP0004947_skin_inflammation1.24137260
53MP0003045_fibrosis1.20535825
54MP0005451_abnormal_body_composition1.19893579
55MP0008260_abnormal_autophagy1.18391421
56MP0002006_tumorigenesis1.17058652
57MP0003724_increased_susceptibility_to1.15119399
58MP0000371_diluted_coat_color1.13826608
59MP0005397_hematopoietic_system_phenotyp1.13737431
60MP0001545_abnormal_hematopoietic_system1.13737431
61MP0009840_abnormal_foam_cell1.11476662
62MP0008004_abnormal_stomach_pH1.11474995
63MP0006054_spinal_hemorrhage1.08517483
64MP0002095_abnormal_skin_pigmentation1.06152405
65MP0002138_abnormal_hepatobiliary_system1.04706782
66MP0002933_joint_inflammation1.00771066
67MP0002132_abnormal_respiratory_system0.99064090
68MP0000343_altered_response_to0.98103610
69MP0000490_abnormal_crypts_of0.94827801
70MP0004381_abnormal_hair_follicle0.91647789
71MP0002998_abnormal_bone_remodeling0.91314183
72MP0003075_altered_response_to0.91310885
73MP0001851_eye_inflammation0.90992093
74MP0000249_abnormal_blood_vessel0.90270775
75MP0002693_abnormal_pancreas_physiology0.88935903
76MP0001663_abnormal_digestive_system0.87736971
77MP0001986_abnormal_taste_sensitivity0.86862547
78MP0005075_abnormal_melanosome_morpholog0.85360763
79MP0008007_abnormal_cellular_replicative0.84131851
80MP0003828_pulmonary_edema0.80857368
81MP0005670_abnormal_white_adipose0.79875107
82MP0005164_abnormal_response_to0.77535227
83MP0000858_altered_metastatic_potential0.76936777
84MP0005166_decreased_susceptibility_to0.75530116
85MP0003690_abnormal_glial_cell0.73910920
86MP0008057_abnormal_DNA_replication0.71922534
87MP0002277_abnormal_respiratory_mucosa0.70641548
88MP0003806_abnormal_nucleotide_metabolis0.70379139
89MP0002136_abnormal_kidney_physiology0.68360965
90MP0002019_abnormal_tumor_incidence0.67905119
91MP0003252_abnormal_bile_duct0.67557229
92MP0002877_abnormal_melanocyte_morpholog0.67266707
93MP0005167_abnormal_blood-brain_barrier0.66196776
94MP0009763_increased_sensitivity_to0.64993172
95MP0009765_abnormal_xenobiotic_induced0.64134110
96MP0000767_abnormal_smooth_muscle0.63845719
97MP0005390_skeleton_phenotype0.63166678
98MP0001915_intracranial_hemorrhage0.62746453
99MP0003566_abnormal_cell_adhesion0.62629083
100MP0003656_abnormal_erythrocyte_physiolo0.62599463
101MP0008873_increased_physiological_sensi0.61939143
102MP0010307_abnormal_tumor_latency0.61815323
103MP0008874_decreased_physiological_sensi0.61199362
104MP0002009_preneoplasia0.61030883
105MP0003448_altered_tumor_morphology0.61023886
106MP0003195_calcinosis0.60010375
107MP0000609_abnormal_liver_physiology0.59046282
108MP0002332_abnormal_exercise_endurance0.58019623
109MP0003279_aneurysm0.57834502
110MP0009764_decreased_sensitivity_to0.57761678
111MP0003795_abnormal_bone_structure0.57445772
112MP0000604_amyloidosis0.55802685
113MP0009115_abnormal_fat_cell0.55473860
114MP0008058_abnormal_DNA_repair0.55472414
115MP0000598_abnormal_liver_morphology0.54118812
116MP0002075_abnormal_coat/hair_pigmentati0.53957003
117MP0004883_abnormal_blood_vessel0.53912345
118MP0003787_abnormal_imprinting0.53911064
119MP0005535_abnormal_body_temperature0.50955276
120MP0005319_abnormal_enzyme/_coenzyme0.50561409
121MP0005584_abnormal_enzyme/coenzyme_acti0.46969806

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.83714542
2Recurrent bacterial skin infections (HP:0005406)5.81095655
3Agammaglobulinemia (HP:0004432)5.27149438
4Systemic lupus erythematosus (HP:0002725)5.23140458
5Colitis (HP:0002583)5.04490790
6Optic neuritis (HP:0100653)4.67832759
7Retrobulbar optic neuritis (HP:0100654)4.67832759
8Orchitis (HP:0100796)4.61571414
9IgM deficiency (HP:0002850)4.54508661
10Glomerulonephritis (HP:0000099)4.49378107
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.36017079
12Cellulitis (HP:0100658)4.35177534
13Inflammation of the large intestine (HP:0002037)4.33848634
14Gastrointestinal inflammation (HP:0004386)4.24193778
15Eczematoid dermatitis (HP:0000976)4.22852803
16Recurrent viral infections (HP:0004429)4.21518111
17Stomatitis (HP:0010280)4.20269689
18Abnormality of liposaccharide metabolism (HP:0010968)4.08158527
19Abnormality of glycosphingolipid metabolism (HP:0004343)4.08158527
20Abnormality of glycolipid metabolism (HP:0010969)4.08158527
21Recurrent skin infections (HP:0001581)3.89528908
22Increased cerebral lipofuscin (HP:0011813)3.75240349
23Gastrointestinal infarctions (HP:0005244)3.73645686
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.72797957
25Meningitis (HP:0001287)3.61172518
26Gastrointestinal stroma tumor (HP:0100723)3.58513333
27Panhypogammaglobulinemia (HP:0003139)3.54892233
28Recurrent fungal infections (HP:0002841)3.54832627
29Dysostosis multiplex (HP:0000943)3.48524041
30Recurrent bronchitis (HP:0002837)3.46294994
31Hemoptysis (HP:0002105)3.43432400
32Chronic otitis media (HP:0000389)3.36380919
33Recurrent cutaneous fungal infections (HP:0011370)3.31054745
34Chronic mucocutaneous candidiasis (HP:0002728)3.31054745
35Thrombocytosis (HP:0001894)3.30507469
36Vacuolated lymphocytes (HP:0001922)3.27811663
37Keratoconjunctivitis sicca (HP:0001097)3.25332911
38Keratoconjunctivitis (HP:0001096)3.10289410
39Recurrent gram-negative bacterial infections (HP:0005420)3.07875860
40Agnosia (HP:0010524)3.07614890
41Urticaria (HP:0001025)3.06499037
42Mediastinal lymphadenopathy (HP:0100721)2.99173663
43Chest pain (HP:0100749)2.99131008
44Spontaneous hematomas (HP:0007420)2.97292202
45Chronic diarrhea (HP:0002028)2.96418321
46Abnormality of T cell physiology (HP:0011840)2.96064615
47Complement deficiency (HP:0004431)2.95269428
48Lymphopenia (HP:0001888)2.94898017
49Interstitial pulmonary disease (HP:0006530)2.89562263
50Elevated erythrocyte sedimentation rate (HP:0003565)2.89388890
51Recurrent sinusitis (HP:0011108)2.88645233
52Osteomyelitis (HP:0002754)2.88422005
53Vasculitis (HP:0002633)2.87567432
54Obstructive lung disease (HP:0006536)2.87440741
55Chronic obstructive pulmonary disease (HP:0006510)2.87440741
56Abnormality of macrophages (HP:0004311)2.84608481
57Hematochezia (HP:0002573)2.83415077
58T lymphocytopenia (HP:0005403)2.82982532
59Abnormality of T cell number (HP:0011839)2.81951933
60Spinal cord lesions (HP:0100561)2.80462390
61Syringomyelia (HP:0003396)2.80462390
62Myositis (HP:0100614)2.78110435
63Spondylolisthesis (HP:0003302)2.77762318
64Leukocytosis (HP:0001974)2.76468484
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.75403536
66Disinhibition (HP:0000734)2.66439178
67Recurrent pneumonia (HP:0006532)2.66410992
68Mucopolysacchariduria (HP:0008155)2.60465110
69Urinary glycosaminoglycan excretion (HP:0003541)2.60465110
70Abnormality of complement system (HP:0005339)2.59161500
71Increased IgM level (HP:0003496)2.57657748
72Recurrent lower respiratory tract infections (HP:0002783)2.56219051
73Gingival bleeding (HP:0000225)2.55151894
74Verrucae (HP:0200043)2.54014159
75Papilloma (HP:0012740)2.54014159
76Amyloidosis (HP:0011034)2.52434869
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51591010
78Abnormality of the pleura (HP:0002103)2.51531053
79Pulmonary embolism (HP:0002204)2.49808706
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47864024
81Abnormality of polysaccharide metabolism (HP:0011012)2.47864024
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47864024
83Abnormal platelet function (HP:0011869)2.45747656
84Impaired platelet aggregation (HP:0003540)2.45747656
85Emphysema (HP:0002097)2.45066294
86Gangrene (HP:0100758)2.43470639
87Abnormality of the fingertips (HP:0001211)2.40962130
88Episodic fever (HP:0001954)2.37897350
89Gingivitis (HP:0000230)2.35696022
90Thoracic kyphosis (HP:0002942)2.35054977
91Anorexia (HP:0002039)2.34015574
92Sepsis (HP:0100806)2.32274781
93Thyroiditis (HP:0100646)2.30939119
94Absent frontal sinuses (HP:0002688)2.30060104
95Abnormality of T cells (HP:0002843)2.29958151
96Granulocytopenia (HP:0001913)2.28890873
97Nephritis (HP:0000123)2.26800374
98Petechiae (HP:0000967)2.26417400
99Skin rash (HP:0000988)2.24119241
100Chronic sinusitis (HP:0011109)2.23495918
101Prolonged bleeding time (HP:0003010)2.22985278
102Periodontitis (HP:0000704)2.21367985
103Abnormality of the prostate (HP:0008775)2.19251600
104Fatigue (HP:0012378)2.18435785
105IgA deficiency (HP:0002720)2.17168431
106Polyneuropathy (HP:0001271)2.14548547
107Increased IgE level (HP:0003212)2.14028270
108Cerebral aneurysm (HP:0004944)2.13503800
109Eosinophilia (HP:0001880)2.12484166
110Autoimmune thrombocytopenia (HP:0001973)2.11763243
111Viral hepatitis (HP:0006562)2.11409245
112Purpura (HP:0000979)2.11403283
113Epistaxis (HP:0000421)2.08747766
114Hypochromic anemia (HP:0001931)2.08692917
115Hypergammaglobulinemia (HP:0010702)2.08002375
116Loss of speech (HP:0002371)2.07608866
117Retinal atrophy (HP:0001105)2.07356485
118Restrictive lung disease (HP:0002091)2.07285012
119Pustule (HP:0200039)2.06958535
120Pulmonary infiltrates (HP:0002113)2.04227101
121IgG deficiency (HP:0004315)2.04043402
122Vertigo (HP:0002321)2.02748959
123Abnormality of the endocardium (HP:0004306)2.02490600
124Cheilitis (HP:0100825)2.01422793
125Leukopenia (HP:0001882)2.01001818
126Abnormality of the thoracic spine (HP:0100711)1.97807595
127Increased serum ferritin (HP:0003281)1.96407402
128Abnormality of the peritoneum (HP:0002585)1.96154900
129Arthralgia (HP:0002829)1.95957688
130Basal ganglia calcification (HP:0002135)1.95883814
131Papilledema (HP:0001085)1.95387945
132Bronchitis (HP:0012387)1.94758655
133Arterial thrombosis (HP:0004420)1.94636771
134Albinism (HP:0001022)1.93390406
135Encephalitis (HP:0002383)1.92497699
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92309385
137Lymphoma (HP:0002665)1.90916483
138Skin ulcer (HP:0200042)1.90152094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.89103219
2CSF1R3.68425631
3TGFBR23.65017441
4TYK22.89091400
5BLK2.87298884
6IRAK32.73743759
7RIPK42.59849399
8IRAK42.55637740
9MAP3K142.28834338
10BTK2.28133130
11MAPK152.27802255
12KIT2.27046180
13ERN12.20600961
14EEF2K1.95319090
15TBK11.92859277
16MAP3K131.88624148
17SYK1.88327980
18ZAP701.87435809
19MAP3K101.85304359
20STK101.83504917
21IKBKB1.82399461
22CLK11.80899643
23JAK31.72698693
24JAK11.72126464
25PRPF4B1.68266302
26FLT31.64350569
27FES1.53137365
28TAOK31.52124502
29CSK1.50418112
30HCK1.49098749
31TEC1.46546712
32LYN1.45907038
33MAP2K31.42813585
34TAOK11.22064949
35MAP3K31.20961492
36SIK21.20638531
37MAP3K111.17442996
38LCK1.17218468
39GRK61.15857508
40GRK71.15388524
41ITK1.13782400
42IKBKE1.10791443
43CAMK1D1.09377868
44CDC42BPA1.09151890
45CHUK1.05126436
46LRRK21.01066105
47MATK0.99589304
48HIPK20.94038917
49MAP3K10.92017666
50EPHB10.91116018
51TSSK60.91091659
52IRAK10.85633562
53RPS6KA40.83580729
54BRD40.80400800
55CAMK1G0.79855529
56MARK30.77897925
57MAP3K80.76483557
58JAK20.76421283
59PKN20.75336644
60PDK10.74429236
61MAPK120.72921386
62PAK40.72521256
63MARK20.71851320
64TESK20.69356983
65NEK90.65424601
66CDK120.65234687
67FYN0.62503013
68PIM10.62371030
69PRKD20.62358986
70TXK0.62127514
71SIK30.60584159
72FRK0.58941601
73CDK190.58647998
74PTK2B0.58003073
75MAP3K70.55975797
76PASK0.55483780
77MAPKAPK20.55153388
78PTK60.54682315
79VRK10.54521542
80MAPK70.53275697
81BMPR20.52866873
82YES10.52031525
83EPHA30.50794951
84SCYL20.50726083
85TNK20.50577551
86MAPK40.48352242
87TAOK20.48182093
88PRKCQ0.48172009
89ACVR1B0.47518875
90STK40.46741843
91ABL10.46444211
92MAPK110.45953333
93CDK60.44067471
94PIK3CG0.42995806
95EIF2AK30.42663251
96RPS6KA60.42339360
97CDK90.42294397
98PDPK10.41915986
99IRAK20.41634366
100TRPM70.41331131
101DAPK20.40917362
102MAP3K50.40635842
103STK110.39016215
104DYRK1B0.37767577
105ADRBK20.37188001
106RPS6KL10.34049536
107RPS6KC10.34049536
108FGR0.33838610
109KSR20.33305519
110FGFR40.33230398
111CAMKK20.32588486
112RPS6KA20.31750584
113PRKCD0.31696446
114FGFR30.31559533
115EGFR0.30662042
116CAMKK10.30251902
117SGK30.29712415
118PRKD10.29511353
119SGK20.29306607
120ATR0.29012318
121MAPKAPK30.28684683
122CAMK40.28654149
123MAP2K60.27998858
124CCNB10.27284022
125MAP3K60.27279340
126GRK10.26925826
127NLK0.26829396
128CDK40.26540570
129MOS0.24892619

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.09447510
2Autoimmune thyroid disease_Homo sapiens_hsa053203.43844188
3Asthma_Homo sapiens_hsa053103.34422243
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.18362134
5Other glycan degradation_Homo sapiens_hsa005113.03335318
6Primary immunodeficiency_Homo sapiens_hsa053402.95968242
7Osteoclast differentiation_Homo sapiens_hsa043802.83847538
8Type I diabetes mellitus_Homo sapiens_hsa049402.82637941
9Leishmaniasis_Homo sapiens_hsa051402.75439730
10Staphylococcus aureus infection_Homo sapiens_hsa051502.64236757
11Antigen processing and presentation_Homo sapiens_hsa046122.63435359
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.36328334
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22102835
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06212233
15Hematopoietic cell lineage_Homo sapiens_hsa046402.04145992
16Lysosome_Homo sapiens_hsa041422.00994615
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93262141
18Measles_Homo sapiens_hsa051621.91290406
19Pertussis_Homo sapiens_hsa051331.87771111
20Tuberculosis_Homo sapiens_hsa051521.77476047
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68870737
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61646573
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.58291241
24Toxoplasmosis_Homo sapiens_hsa051451.57765471
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56619291
26Chemokine signaling pathway_Homo sapiens_hsa040621.53947457
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53609752
28Influenza A_Homo sapiens_hsa051641.51484806
29Herpes simplex infection_Homo sapiens_hsa051681.46347997
30Legionellosis_Homo sapiens_hsa051341.39534224
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34512679
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34480504
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33458833
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.28709484
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28460859
36Platelet activation_Homo sapiens_hsa046111.26600262
37Apoptosis_Homo sapiens_hsa042101.23223681
38T cell receptor signaling pathway_Homo sapiens_hsa046601.22711019
39Acute myeloid leukemia_Homo sapiens_hsa052211.22697443
40Chronic myeloid leukemia_Homo sapiens_hsa052201.20384780
41Shigellosis_Homo sapiens_hsa051311.16530657
42Hepatitis B_Homo sapiens_hsa051611.14002380
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.10420062
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07646508
45Pancreatic cancer_Homo sapiens_hsa052121.07523560
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.05591957
47Epstein-Barr virus infection_Homo sapiens_hsa051691.04297506
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00294723
49TNF signaling pathway_Homo sapiens_hsa046680.91495757
50Salmonella infection_Homo sapiens_hsa051320.88992293
51Malaria_Homo sapiens_hsa051440.88964435
52Base excision repair_Homo sapiens_hsa034100.87328357
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81771814
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.80584099
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80072226
56N-Glycan biosynthesis_Homo sapiens_hsa005100.78381386
57Non-small cell lung cancer_Homo sapiens_hsa052230.77764642
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76541117
59Notch signaling pathway_Homo sapiens_hsa043300.75981909
60Non-homologous end-joining_Homo sapiens_hsa034500.75230094
61Hepatitis C_Homo sapiens_hsa051600.74557278
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74467984
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73361340
64ABC transporters_Homo sapiens_hsa020100.73085588
65DNA replication_Homo sapiens_hsa030300.69169343
66Mismatch repair_Homo sapiens_hsa034300.69113629
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68158613
68Viral myocarditis_Homo sapiens_hsa054160.67064975
69African trypanosomiasis_Homo sapiens_hsa051430.63930530
70Inositol phosphate metabolism_Homo sapiens_hsa005620.62630376
71Viral carcinogenesis_Homo sapiens_hsa052030.62103234
72HTLV-I infection_Homo sapiens_hsa051660.57621146
73Complement and coagulation cascades_Homo sapiens_hsa046100.55743357
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55226340
75Prolactin signaling pathway_Homo sapiens_hsa049170.54989909
76Prion diseases_Homo sapiens_hsa050200.54971338
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54835171
78Systemic lupus erythematosus_Homo sapiens_hsa053220.54646332
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53880198
80Insulin resistance_Homo sapiens_hsa049310.53597190
81Endocytosis_Homo sapiens_hsa041440.52529701
82Phagosome_Homo sapiens_hsa041450.50998245
83Colorectal cancer_Homo sapiens_hsa052100.50322038
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49990208
85Dorso-ventral axis formation_Homo sapiens_hsa043200.49315470
86VEGF signaling pathway_Homo sapiens_hsa043700.45805720
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.45703372
88Type II diabetes mellitus_Homo sapiens_hsa049300.43835056
89Lysine degradation_Homo sapiens_hsa003100.42846511
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42675236
91Homologous recombination_Homo sapiens_hsa034400.42281809
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41034284
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40529228
94MAPK signaling pathway_Homo sapiens_hsa040100.39654970
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.38828880
96Small cell lung cancer_Homo sapiens_hsa052220.36275687
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34429923
98FoxO signaling pathway_Homo sapiens_hsa040680.33712091
99GnRH signaling pathway_Homo sapiens_hsa049120.33668794
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32384825
101Graft-versus-host disease_Homo sapiens_hsa053320.31482582
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31436835
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.30902473
104Linoleic acid metabolism_Homo sapiens_hsa005910.30823612
105Allograft rejection_Homo sapiens_hsa053300.30350937
106Arachidonic acid metabolism_Homo sapiens_hsa005900.29677533
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29525013
108Choline metabolism in cancer_Homo sapiens_hsa052310.28153418
109Ether lipid metabolism_Homo sapiens_hsa005650.28060801
110Regulation of autophagy_Homo sapiens_hsa041400.27590932
111HIF-1 signaling pathway_Homo sapiens_hsa040660.26275137
112Rheumatoid arthritis_Homo sapiens_hsa053230.25057807
113Collecting duct acid secretion_Homo sapiens_hsa049660.24332590
114Protein export_Homo sapiens_hsa030600.24070825
115Renal cell carcinoma_Homo sapiens_hsa052110.24042628
116Amoebiasis_Homo sapiens_hsa051460.23621430
117Prostate cancer_Homo sapiens_hsa052150.23289237
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22664601
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22037733
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.21685689
121Estrogen signaling pathway_Homo sapiens_hsa049150.21657890
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20992632

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