FFAR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle remodeling (GO:0034374)9.18811182
2glandular epithelial cell differentiation (GO:0002067)8.92212157
3intestinal epithelial cell development (GO:0060576)8.71895484
4COPI coating of Golgi vesicle (GO:0048205)7.60505897
5Golgi transport vesicle coating (GO:0048200)7.60505897
6bile acid and bile salt transport (GO:0015721)7.05219649
7phosphatidylinositol acyl-chain remodeling (GO:0036149)6.63714902
8phosphatidylserine acyl-chain remodeling (GO:0036150)6.10179673
9positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.06682239
10endocrine pancreas development (GO:0031018)6.03888542
11lung secretory cell differentiation (GO:0061140)5.75829636
12phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.75488098
13regulation of T-helper 1 cell differentiation (GO:0045625)5.69225956
14phenol-containing compound catabolic process (GO:0019336)5.60062456
15regulation of vitamin D biosynthetic process (GO:0060556)5.57631760
16regulation of chronic inflammatory response (GO:0002676)5.47573829
17negative regulation of interleukin-12 production (GO:0032695)5.12406603
18columnar/cuboidal epithelial cell development (GO:0002066)5.12249252
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.98724187
20cellular response to type I interferon (GO:0071357)4.96325393
21type I interferon signaling pathway (GO:0060337)4.96325393
22COPII vesicle coating (GO:0048208)4.93624130
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.93318349
24response to type I interferon (GO:0034340)4.89779133
25phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.87212780
26protein maturation by protein folding (GO:0022417)4.85010935
27regulation of cytokine secretion involved in immune response (GO:0002739)4.84137991
28regulation of interferon-alpha production (GO:0032647)4.77061824
29response to peptidoglycan (GO:0032494)4.66395003
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.57817896
31peptide hormone processing (GO:0016486)4.54158326
32signal peptide processing (GO:0006465)4.49841108
33maintenance of gastrointestinal epithelium (GO:0030277)4.39861360
34regulation of vitamin metabolic process (GO:0030656)4.38587286
35branching involved in labyrinthine layer morphogenesis (GO:0060670)4.32519385
36positive regulation of heat generation (GO:0031652)4.29405165
37phosphatidylserine metabolic process (GO:0006658)4.29213569
38regulation of fever generation (GO:0031620)4.22500660
39phosphatidylcholine acyl-chain remodeling (GO:0036151)4.20357617
40sulfation (GO:0051923)4.13003144
41macrophage activation involved in immune response (GO:0002281)4.10349445
42cerebellar Purkinje cell layer development (GO:0021680)4.08852799
43nucleotide transmembrane transport (GO:1901679)4.08798490
44intestinal absorption (GO:0050892)4.05073030
45lipopolysaccharide-mediated signaling pathway (GO:0031663)4.03042914
46columnar/cuboidal epithelial cell differentiation (GO:0002065)4.00614890
47positive regulation of chemokine biosynthetic process (GO:0045080)3.97297791
48insulin secretion (GO:0030073)3.96499237
49negative regulation of cytokine production involved in immune response (GO:0002719)3.95543145
50type B pancreatic cell development (GO:0003323)3.89154037
51defense response to protozoan (GO:0042832)3.84383958
52regulation of type B pancreatic cell apoptotic process (GO:2000674)3.84147550
53regulation of chemokine biosynthetic process (GO:0045073)3.82864223
54positive regulation of cell fate commitment (GO:0010455)3.80792420
55glandular epithelial cell development (GO:0002068)3.80603557
56neutrophil activation involved in immune response (GO:0002283)3.79555141
57positive regulation of interferon-alpha production (GO:0032727)3.78900725
58protein-lipid complex remodeling (GO:0034368)3.75747045
59macromolecular complex remodeling (GO:0034367)3.75747045
60plasma lipoprotein particle remodeling (GO:0034369)3.75747045
61germinal center formation (GO:0002467)3.73349710
62response to protozoan (GO:0001562)3.72619430
63immunoglobulin mediated immune response (GO:0016064)3.71721588
64positive regulation of gamma-delta T cell activation (GO:0046645)3.71270115
65positive regulation of type 2 immune response (GO:0002830)3.69965322
66myeloid dendritic cell differentiation (GO:0043011)3.67403915
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63872274
68interferon-gamma-mediated signaling pathway (GO:0060333)3.63857175
69T-helper 1 type immune response (GO:0042088)3.61959000
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60411804
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.58095832
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57911617
73positive regulation of insulin secretion (GO:0032024)3.56038228
74negative regulation of viral genome replication (GO:0045071)3.55504851
75regulation of interleukin-8 biosynthetic process (GO:0045414)3.54240593
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.51399290
77response to hepatocyte growth factor (GO:0035728)3.49001816
78cellular response to hepatocyte growth factor stimulus (GO:0035729)3.49001816
79vesicle coating (GO:0006901)3.46199663
80negative regulation of nitric oxide biosynthetic process (GO:0045019)3.45516291
81alditol phosphate metabolic process (GO:0052646)3.44816954
82bile acid metabolic process (GO:0008206)3.44086583
83inner ear receptor cell development (GO:0060119)3.43510408
84regulation of T-helper 2 cell differentiation (GO:0045628)3.42278296
85protein targeting to Golgi (GO:0000042)3.41703713
86regulation of macrophage derived foam cell differentiation (GO:0010743)3.41149130
87positive regulation of nuclease activity (GO:0032075)3.40978440
88NIK/NF-kappaB signaling (GO:0038061)3.39918010
89regulation of T-helper cell differentiation (GO:0045622)3.39907676
90neurotransmitter catabolic process (GO:0042135)3.39599825
91regulation of immunoglobulin secretion (GO:0051023)3.39337685
92negative regulation of amino acid transport (GO:0051956)3.37703684
93catechol-containing compound biosynthetic process (GO:0009713)3.37652328
94catecholamine biosynthetic process (GO:0042423)3.37652328
95regulation of membrane protein ectodomain proteolysis (GO:0051043)3.35954780
96negative regulation of keratinocyte proliferation (GO:0010839)3.34785769
97GDP-mannose metabolic process (GO:0019673)3.33219236
98regulation of interferon-beta biosynthetic process (GO:0045357)3.33149157
99regulation of nitric oxide biosynthetic process (GO:0045428)3.32905917
100regulation of interleukin-12 production (GO:0032655)3.32309346
101keratinocyte development (GO:0003334)3.31067267
102digestive system process (GO:0022600)3.30793768
103regulation of insulin secretion (GO:0050796)3.30426079
104positive regulation of nitric oxide biosynthetic process (GO:0045429)3.29449476
105ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.28668548
106negative regulation of norepinephrine secretion (GO:0010700)3.28427050
107positive regulation of NF-kappaB import into nucleus (GO:0042346)3.28239128
108regulation of heat generation (GO:0031650)3.27391613
109negative regulation of cell fate commitment (GO:0010454)3.26926080
110granulocyte activation (GO:0036230)3.25167045
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24375499
112positive regulation by organism of defense response of other organism involved in symbiotic interact3.24375499
113modulation by symbiont of host immune response (GO:0052553)3.24375499
114positive regulation by symbiont of host defense response (GO:0052509)3.24375499
115modulation by symbiont of host defense response (GO:0052031)3.24375499
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24375499
117phosphatidic acid metabolic process (GO:0046473)3.24030109
118phosphatidic acid biosynthetic process (GO:0006654)3.24030109
119negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.23156979
120regulation of type 2 immune response (GO:0002828)3.22328817
121regulation of type I interferon-mediated signaling pathway (GO:0060338)3.22069216
122negative regulation of growth of symbiont in host (GO:0044130)3.21818772
123negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.21818772
124modulation of growth of symbiont involved in interaction with host (GO:0044144)3.21818772
125regulation of growth of symbiont in host (GO:0044126)3.21818772
126negative regulation of production of molecular mediator of immune response (GO:0002701)3.20652655
127positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18993875
128negative regulation of myeloid cell apoptotic process (GO:0033033)3.15780841
129myeloid dendritic cell activation (GO:0001773)3.15581644
130positive regulation of natural killer cell differentiation (GO:0032825)3.14253843
131digestion (GO:0007586)3.12946373
132ER overload response (GO:0006983)3.12877266
133regulation of mononuclear cell migration (GO:0071675)3.12173497
134response to muramyl dipeptide (GO:0032495)3.10529844
135cellular response to lipopolysaccharide (GO:0071222)3.09932674
136negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.08857453
137activation of MAPKKK activity (GO:0000185)3.08642032
138positive regulation of antigen processing and presentation (GO:0002579)3.07931632
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07376889
140purine deoxyribonucleotide catabolic process (GO:0009155)3.07047954
141regulation of antigen processing and presentation (GO:0002577)3.07042845
142regulation of nuclease activity (GO:0032069)3.06738806
143positive regulation of interferon-beta production (GO:0032728)3.06333507
144epithelial structure maintenance (GO:0010669)3.05008250
145positive regulation of interleukin-6 production (GO:0032755)3.04895391
146N-acetylglucosamine metabolic process (GO:0006044)3.04804175
147negative regulation of catecholamine secretion (GO:0033604)3.04575650
148nitric oxide mediated signal transduction (GO:0007263)3.04533455
149exocrine pancreas development (GO:0031017)3.04385526
150cellular response to molecule of bacterial origin (GO:0071219)3.04211351
151detection of other organism (GO:0098543)3.04050706
152regulation of heterotypic cell-cell adhesion (GO:0034114)3.01645541
153* regulation of peptide hormone secretion (GO:0090276)2.99075737
154regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98567119
155endoplasmic reticulum unfolded protein response (GO:0030968)2.97892194
156regulation of NF-kappaB import into nucleus (GO:0042345)2.97828148
157positive regulation of lymphocyte apoptotic process (GO:0070230)2.97804510
158positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.96946451
159positive regulation of defense response to virus by host (GO:0002230)2.96149771
160positive regulation of T-helper cell differentiation (GO:0045624)2.96148511
161negative regulation of protein tyrosine kinase activity (GO:0061099)2.95666733
162negative regulation of cAMP-mediated signaling (GO:0043951)2.95576029
163peptide hormone secretion (GO:0030072)2.95443052
164positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95118027
165L-alpha-amino acid transmembrane transport (GO:1902475)2.94578351
166* regulation of peptide secretion (GO:0002791)2.94326990
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.92179159
168negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.91923874
169positive regulation of interleukin-12 production (GO:0032735)2.91794606
170detection of molecule of bacterial origin (GO:0032490)2.91788384
171positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91373344
172positive regulation of peptide hormone secretion (GO:0090277)2.90660566
173monocyte chemotaxis (GO:0002548)2.90245474
174dendritic cell differentiation (GO:0097028)2.90048276
175interferon-gamma secretion (GO:0072643)2.89911253
176cellular response to interferon-alpha (GO:0035457)2.88961931
177positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88587464
178regulation of inflammatory response to antigenic stimulus (GO:0002861)2.88433332
179plasma lipoprotein particle organization (GO:0071827)2.88386753
180cellular response to interferon-gamma (GO:0071346)2.87888589
181cellular response to unfolded protein (GO:0034620)2.86119945
182intestinal cholesterol absorption (GO:0030299)2.86102347
183negative regulation of cell killing (GO:0031342)2.85729947
184regulation of podosome assembly (GO:0071801)2.85656588
185peptide secretion (GO:0002790)2.84957879
186sequestering of metal ion (GO:0051238)2.84885414
187norepinephrine metabolic process (GO:0042415)2.84350769
188ER to Golgi vesicle-mediated transport (GO:0006888)2.83762917
189phosphatidylglycerol metabolic process (GO:0046471)2.82853398
190intra-Golgi vesicle-mediated transport (GO:0006891)2.82806997
191positive regulation of peptide secretion (GO:0002793)2.81819068
192UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80558791
193glucosamine-containing compound metabolic process (GO:1901071)2.80253855
194protein-lipid complex subunit organization (GO:0071825)2.79658642
195establishment of protein localization to Golgi (GO:0072600)2.76988015
196regulation of microtubule-based movement (GO:0060632)2.74523875
197cellular response to nutrient (GO:0031670)2.73882141
198cellular response to topologically incorrect protein (GO:0035967)2.72145184
199protein retention in ER lumen (GO:0006621)2.71092541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.08588402
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.46310988
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.62873144
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.44935184
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.97944694
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.78177677
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76735856
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28318000
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17460111
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.10763297
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07181022
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04006722
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.01611308
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.00410172
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.77285011
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70269907
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69963088
18STAT1_20625510_ChIP-Seq_HELA_Human2.57447581
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.48694991
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46128256
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.44099994
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.42474254
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41340565
24SOX2_27498859_Chip-Seq_STOMACH_Mouse2.40046769
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.39822121
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39542846
27REST_21632747_ChIP-Seq_MESCs_Mouse2.39109133
28ESR1_20079471_ChIP-ChIP_T-47D_Human2.35014048
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.31576511
30CTCF_27219007_Chip-Seq_Bcells_Human2.11080897
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.11038341
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.08693186
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06564140
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01399286
35VDR_24787735_ChIP-Seq_THP-1_Human1.96919417
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96682376
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95722417
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91754648
39VDR_24763502_ChIP-Seq_THP-1_Human1.89732383
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87881679
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83936561
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81280926
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81076879
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.73391279
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72762584
46VDR_21846776_ChIP-Seq_THP-1_Human1.70310531
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70271455
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70081452
49ZNF263_19887448_ChIP-Seq_K562_Human1.66508440
50SPI1_23547873_ChIP-Seq_NB4_Human1.66408497
51RUNX_20019798_ChIP-Seq_JUKART_Human1.65739784
52LXR_22292898_ChIP-Seq_THP-1_Human1.61646409
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.58961555
54GATA1_19941826_ChIP-Seq_K562_Human1.57949255
55SCL_19346495_ChIP-Seq_HPC-7_Human1.56495746
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55979221
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55554524
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55121874
59MAF_26560356_Chip-Seq_TH1_Human1.54290777
60SOX2_20726797_ChIP-Seq_SW620_Human1.53372685
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52687592
62GATA6_25053715_ChIP-Seq_YYC3_Human1.51958269
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51821384
64* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51000958
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50479444
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49656342
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49043724
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48317647
69SA1_27219007_Chip-Seq_Bcells_Human1.45560562
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45184236
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43812050
72* CTCF_20526341_ChIP-Seq_ESCs_Human1.43662725
73GATA1_22025678_ChIP-Seq_K562_Human1.41528175
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.41066118
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.40129228
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40035274
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39729654
78MYB_26560356_Chip-Seq_TH2_Human1.37754398
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37388570
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.37371999
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36408183
82* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35680638
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35595002
84SMC4_20622854_ChIP-Seq_HELA_Human1.35114968
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34797344
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34683529
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34536997
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32803257
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32220008
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.31948977
91TFEB_21752829_ChIP-Seq_HELA_Human1.31798381
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31742719
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30897002
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.29852800
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29049599
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27194754
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.27163226
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26448452
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26390575
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25395655
101PU_27001747_Chip-Seq_BMDM_Mouse1.24909010
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24626471
103RACK7_27058665_Chip-Seq_MCF-7_Human1.21358369
104* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20853043
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.20544134
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19381426
107GATA4_25053715_ChIP-Seq_YYC3_Human1.18673895
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.18615066
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16799989
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16326178
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16321690
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.14160652
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.13943960
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.13868476
115TCF7_22412390_ChIP-Seq_EML_Mouse1.13683602
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13388589
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11517052
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11105202
119MYB_26560356_Chip-Seq_TH1_Human1.10954967
120TET1_21451524_ChIP-Seq_MESCs_Mouse1.10883071
121YY1_22570637_ChIP-Seq_MALME-3M_Human1.10695073
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.10036046
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09789071
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09332429
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.09182150
126KDM2B_26808549_Chip-Seq_DND41_Human1.08999228
127LXR_22158963_ChIP-Seq_LIVER_Mouse1.08781950
128VDR_22108803_ChIP-Seq_LS180_Human1.08077590
129GATA3_26560356_Chip-Seq_TH2_Human1.07734030
130UTX_26944678_Chip-Seq_JUKART_Human1.07633157
131TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07570557
132ESR1_21235772_ChIP-Seq_MCF-7_Human1.07497129
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07315211
134PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05429884
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05235579
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04159155
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03805322
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02130972
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01109746
140KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01109746
141KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01109746
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00402671
143ZNF274_21170338_ChIP-Seq_K562_Hela1.00270376
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00084439
145EGR1_19032775_ChIP-ChIP_M12_Human0.99809723
146MAF_26560356_Chip-Seq_TH2_Human0.99626899
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99428276
148SPI1_23127762_ChIP-Seq_K562_Human0.98930617
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97720784
150SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.97639340
151EZH2_27294783_Chip-Seq_ESCs_Mouse0.97426082
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97136935
153CREB1_26743006_Chip-Seq_LNCaP_Human0.97035707
154SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96387528
155SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95727628
156TP63_17297297_ChIP-ChIP_HaCaT_Human0.95265382
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93656820
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93584210
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93570266
160* FOXH1_21741376_ChIP-Seq_ESCs_Human0.93251204
161BCAT_22108803_ChIP-Seq_LS180_Human0.93102033
162GATA3_27048872_Chip-Seq_THYMUS_Human0.93020837
163* RARB_27405468_Chip-Seq_BRAIN_Mouse0.92852373
164BCOR_27268052_Chip-Seq_Bcells_Human0.92833601
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91787726
166FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91652264
167UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91277230
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90428588
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89290262
170MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89231743
171SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88569607
172E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87921986
173CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87640655
174SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87042000
175KDM2B_26808549_Chip-Seq_K562_Human0.86568405
176GATA2_19941826_ChIP-Seq_K562_Human0.85412889
177PHF8_20622854_ChIP-Seq_HELA_Human0.84359126
178CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84350157
179GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81423429
180PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77328948
181JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76646391
182RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76420050
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76214446
184GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74183668
185SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74139634
186IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72763125
187KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70965133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.55314615
2MP0002877_abnormal_melanocyte_morpholog5.07853575
3MP0003724_increased_susceptibility_to4.80888459
4MP0003283_abnormal_digestive_organ4.66179312
5MP0009780_abnormal_chondrocyte_physiolo4.66088303
6MP0010386_abnormal_urinary_bladder4.35169441
7MP0003183_abnormal_peptide_metabolism4.12550886
8MP0003436_decreased_susceptibility_to3.58350372
9MP0006082_CNS_inflammation3.57180924
10MP0002909_abnormal_adrenal_gland3.52879410
11MP0004043_abnormal_pH_regulation3.48434619
12MP0009785_altered_susceptibility_to3.47677942
13MP0002693_abnormal_pancreas_physiology3.44525447
14MP0004510_myositis3.43658410
15MP0002148_abnormal_hypersensitivity_rea3.35808004
16MP0000013_abnormal_adipose_tissue3.33791220
17MP0001835_abnormal_antigen_presentation3.26116860
18MP0001944_abnormal_pancreas_morphology3.07867125
19MP0005000_abnormal_immune_tolerance2.81659982
20MP0002822_catalepsy2.80469789
21MP0001790_abnormal_immune_system2.79142510
22MP0005387_immune_system_phenotype2.79142510
23MP0004858_abnormal_nervous_system2.69303165
24MP0005671_abnormal_response_to2.63820089
25MP0005025_abnormal_response_to2.56079026
26MP0008004_abnormal_stomach_pH2.52258991
27MP0002419_abnormal_innate_immunity2.47129636
28MP0005379_endocrine/exocrine_gland_phen2.37384795
29MP0009764_decreased_sensitivity_to2.32725681
30MP0004264_abnormal_extraembryonic_tissu2.31844994
31MP0000678_abnormal_parathyroid_gland2.30000822
32MP0001533_abnormal_skeleton_physiology2.28648980
33MP0001666_abnormal_nutrient_absorption2.18786107
34MP0002723_abnormal_immune_serum2.18196974
35MP0005085_abnormal_gallbladder_physiolo2.15258768
36MP0001800_abnormal_humoral_immune2.13495892
37MP0003075_altered_response_to2.11832405
38MP0002452_abnormal_antigen_presenting2.10671288
39MP0004947_skin_inflammation2.08725661
40MP0003195_calcinosis2.08535173
41MP0004270_analgesia2.04725193
42MP0000462_abnormal_digestive_system2.03669000
43MP0009278_abnormal_bone_marrow2.03391358
44MP0002638_abnormal_pupillary_reflex2.00165080
45MP0003866_abnormal_defecation2.00127023
46MP0002332_abnormal_exercise_endurance1.98753060
47MP0004185_abnormal_adipocyte_glucose1.98705031
48MP0003172_abnormal_lysosome_physiology1.95804718
49MP0005365_abnormal_bile_salt1.86576126
50MP0002078_abnormal_glucose_homeostasis1.85895136
51MP0000538_abnormal_urinary_bladder1.84893805
52MP0003252_abnormal_bile_duct1.82581315
53MP0006072_abnormal_retinal_apoptosis1.81685431
54MP0000003_abnormal_adipose_tissue1.80345965
55MP0001845_abnormal_inflammatory_respons1.78723901
56MP0001819_abnormal_immune_cell1.76398875
57MP0002420_abnormal_adaptive_immunity1.75241975
58MP0001853_heart_inflammation1.69687630
59MP0002254_reproductive_system_inflammat1.69309789
60MP0005397_hematopoietic_system_phenotyp1.65264657
61MP0001545_abnormal_hematopoietic_system1.65264657
62MP0000343_altered_response_to1.63804877
63MP0005670_abnormal_white_adipose1.63380726
64MP0008469_abnormal_protein_level1.62038233
65MP0005451_abnormal_body_composition1.60921259
66MP0003453_abnormal_keratinocyte_physiol1.60834608
67MP0000685_abnormal_immune_system1.59033079
68MP0002405_respiratory_system_inflammati1.54233829
69MP0005167_abnormal_blood-brain_barrier1.50332923
70MP0002277_abnormal_respiratory_mucosa1.50019948
71MP0006054_spinal_hemorrhage1.47357777
72MP0009840_abnormal_foam_cell1.45804799
73MP0005220_abnormal_exocrine_pancreas1.45600490
74MP0002734_abnormal_mechanical_nocicepti1.37469034
75MP0002733_abnormal_thermal_nociception1.36315287
76MP0003448_altered_tumor_morphology1.36310626
77MP0005464_abnormal_platelet_physiology1.34975071
78MP0000477_abnormal_intestine_morphology1.33679683
79MP0005058_abnormal_lysosome_morphology1.32789197
80MP0000465_gastrointestinal_hemorrhage1.32380220
81MP0001501_abnormal_sleep_pattern1.31034337
82MP0003806_abnormal_nucleotide_metabolis1.29072486
83MP0005166_decreased_susceptibility_to1.28478522
84MP0003690_abnormal_glial_cell1.27888368
85MP0000716_abnormal_immune_system1.25432827
86* MP0003868_abnormal_feces_composition1.25073147
87MP0001970_abnormal_pain_threshold1.24631068
88MP0002138_abnormal_hepatobiliary_system1.24115576
89MP0003879_abnormal_hair_cell1.24104293
90* MP0003953_abnormal_hormone_level1.24059828
91MP0009333_abnormal_splenocyte_physiolog1.23043365
92MP0002139_abnormal_hepatobiliary_system1.17948701
93MP0000858_altered_metastatic_potential1.17249244
94MP0010155_abnormal_intestine_physiology1.16272254
95MP0009643_abnormal_urine_homeostasis1.15852197
96MP0005076_abnormal_cell_differentiation1.15354001
97MP0001440_abnormal_grooming_behavior1.14875553
98MP0004885_abnormal_endolymph1.11041721
99MP0001542_abnormal_bone_strength1.09851581
100MP0002998_abnormal_bone_remodeling1.09091336
101MP0000604_amyloidosis1.08715939
102MP0005408_hypopigmentation1.08581706
103MP0008961_abnormal_basal_metabolism1.08342121
104MP0005164_abnormal_response_to1.08324974
105MP0002398_abnormal_bone_marrow1.08133941
106MP0008875_abnormal_xenobiotic_pharmacok1.06767554
107MP0002229_neurodegeneration1.06665461
108* MP0005375_adipose_tissue_phenotype1.06213079
109MP0005310_abnormal_salivary_gland1.05838627
110MP0005360_urolithiasis1.05355686
111MP0001756_abnormal_urination1.03639199
112MP0009763_increased_sensitivity_to1.03556560
113MP0002837_dystrophic_cardiac_calcinosis1.02085027
114MP0005165_increased_susceptibility_to1.00786143
115MP0004133_heterotaxia1.00244813
116MP0001849_ear_inflammation1.00063553
117MP0001765_abnormal_ion_homeostasis0.96972314
118MP0005390_skeleton_phenotype0.96694022
119MP0003191_abnormal_cellular_cholesterol0.94905512
120MP0002429_abnormal_blood_cell0.93244754
121MP0000490_abnormal_crypts_of0.92767484
122MP0005381_digestive/alimentary_phenotyp0.92695218
123MP0002751_abnormal_autonomic_nervous0.91831987
124MP0001529_abnormal_vocalization0.91730444
125MP0000613_abnormal_salivary_gland0.91336420
126MP0000689_abnormal_spleen_morphology0.90721521
127MP0004883_abnormal_blood_vessel0.88930937
128MP0001986_abnormal_taste_sensitivity0.88847753
129MP0003646_muscle_fatigue0.87942424
130MP0009765_abnormal_xenobiotic_induced0.87887637
131MP0005535_abnormal_body_temperature0.87792748
132MP0003656_abnormal_erythrocyte_physiolo0.87627689
133MP0002722_abnormal_immune_system0.87311424
134MP0004019_abnormal_vitamin_homeostasis0.87174455
135MP0003122_maternal_imprinting0.86512737
136MP0003091_abnormal_cell_migration0.83506909
137MP0000631_abnormal_neuroendocrine_gland0.82088433
138MP0003763_abnormal_thymus_physiology0.80176724
139MP0002928_abnormal_bile_duct0.78999428
140MP0001873_stomach_inflammation0.77295214
141* MP0005666_abnormal_adipose_tissue0.77068984
142MP0003119_abnormal_digestive_system0.75898902
143MP0008874_decreased_physiological_sensi0.75392519
144MP0005645_abnormal_hypothalamus_physiol0.73852611
145MP0000470_abnormal_stomach_morphology0.73136485
146MP0002896_abnormal_bone_mineralization0.73064536
147* MP0002118_abnormal_lipid_homeostasis0.72380465
148MP0005266_abnormal_metabolism0.72307889
149MP0002933_joint_inflammation0.70801687
150MP0003634_abnormal_glial_cell0.70393519
151MP0000955_abnormal_spinal_cord0.69103211
152MP0003300_gastrointestinal_ulcer0.66244236
153MP0005023_abnormal_wound_healing0.66131729
154MP0004808_abnormal_hematopoietic_stem0.63681654
155MP0005647_abnormal_sex_gland0.61952747
156MP0001299_abnormal_eye_distance/0.61703813
157MP0000249_abnormal_blood_vessel0.60500809
158MP0001851_eye_inflammation0.60183981
159MP0001764_abnormal_homeostasis0.59642665
160MP0010307_abnormal_tumor_latency0.58778593
161MP0000681_abnormal_thyroid_gland0.58723574
162MP0000920_abnormal_myelination0.57296351
163MP0001663_abnormal_digestive_system0.57216268
164MP0001485_abnormal_pinna_reflex0.56604864
165* MP0005334_abnormal_fat_pad0.55554160
166MP0005646_abnormal_pituitary_gland0.54676673
167MP0010352_gastrointestinal_tract_polyps0.54302824
168MP0003959_abnormal_lean_body0.53794118
169MP0003795_abnormal_bone_structure0.53590203
170MP0002572_abnormal_emotion/affect_behav0.52219471
171MP0001905_abnormal_dopamine_level0.51840816
172MP0008260_abnormal_autophagy0.51457066
173MP0003635_abnormal_synaptic_transmissio0.48854582
174MP0000639_abnormal_adrenal_gland0.48850520
175MP0005253_abnormal_eye_physiology0.48774946
176MP0001919_abnormal_reproductive_system0.48495846
177MP0000230_abnormal_systemic_arterial0.46709871
178MP0004859_abnormal_synaptic_plasticity0.45636846
179MP0004924_abnormal_behavior0.45151577

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.71004965
2Retrobulbar optic neuritis (HP:0100654)6.71004965
3Orchitis (HP:0100796)6.49068305
4Hyperinsulinemic hypoglycemia (HP:0000825)5.76032102
5Stomatitis (HP:0010280)5.74435996
6Myositis (HP:0100614)5.72529453
7Hypoglycemic coma (HP:0001325)5.09028083
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.02881299
9Abnormality of macrophages (HP:0004311)4.79995934
10Insulin-resistant diabetes mellitus (HP:0000831)4.72772099
11Hypoglycemic seizures (HP:0002173)4.71217891
12Keratoconjunctivitis sicca (HP:0001097)4.70326361
13Systemic lupus erythematosus (HP:0002725)4.63523758
14Hypothermia (HP:0002045)4.63077829
15Symptomatic seizures (HP:0011145)4.61691848
16Recurrent bacterial skin infections (HP:0005406)4.40779345
17Keratoconjunctivitis (HP:0001096)4.31790010
18Dysostosis multiplex (HP:0000943)4.17504664
19Eczematoid dermatitis (HP:0000976)4.17166086
20Decreased circulating renin level (HP:0003351)4.12936027
21Recurrent abscess formation (HP:0002722)4.12885066
22Hyperparathyroidism (HP:0000843)4.10182437
23Loss of speech (HP:0002371)4.07945436
24Generalized aminoaciduria (HP:0002909)4.06961749
25Hyperglycemia (HP:0003074)4.05708152
26Menstrual irregularities (HP:0000858)4.05507791
27Disinhibition (HP:0000734)4.04073762
28Abnormality of endocrine pancreas physiology (HP:0012093)4.02015913
29Abnormality of the pancreatic islet cells (HP:0006476)4.02015913
30Vacuolated lymphocytes (HP:0001922)4.01166672
31Abnormal pancreas size (HP:0012094)3.95148655
32Ketoacidosis (HP:0001993)3.91142217
33Nuclear cataract (HP:0100018)3.90388745
34Pancreatic islet-cell hyperplasia (HP:0004510)3.84941642
35Mucopolysacchariduria (HP:0008155)3.81542578
36Urinary glycosaminoglycan excretion (HP:0003541)3.81542578
37Increased cerebral lipofuscin (HP:0011813)3.60011149
38Mediastinal lymphadenopathy (HP:0100721)3.58798467
39Autoimmune thrombocytopenia (HP:0001973)3.58259227
40Late onset (HP:0003584)3.56958383
41Increased IgM level (HP:0003496)3.55795161
42Abdominal distention (HP:0003270)3.50928870
43Large for gestational age (HP:0001520)3.47514273
44Exocrine pancreatic insufficiency (HP:0001738)3.43065643
45Abnormality of polysaccharide metabolism (HP:0011012)3.42982524
46Abnormality of glycosaminoglycan metabolism (HP:0004371)3.42982524
47Abnormality of mucopolysaccharide metabolism (HP:0011020)3.42982524
48Interstitial pulmonary disease (HP:0006530)3.42622144
49Mutism (HP:0002300)3.42440459
50Gangrene (HP:0100758)3.40230919
51Elevated erythrocyte sedimentation rate (HP:0003565)3.36453779
52Abnormality of calcium-phosphate metabolism (HP:0100530)3.29625637
53Pulmonary infiltrates (HP:0002113)3.24691433
54Vasculitis (HP:0002633)3.19567615
55Hypsarrhythmia (HP:0002521)3.14106857
56Parakeratosis (HP:0001036)3.10965202
57Insulin resistance (HP:0000855)3.10261378
58EEG with generalized epileptiform discharges (HP:0011198)3.10158683
59Orthostatic hypotension (HP:0001278)3.07315224
60Bundle branch block (HP:0011710)3.07016744
61Conjugated hyperbilirubinemia (HP:0002908)3.06828483
62Unilateral renal agenesis (HP:0000122)3.05789514
63Recurrent gram-negative bacterial infections (HP:0005420)3.05525009
64Arterial thrombosis (HP:0004420)2.96794589
65Protuberant abdomen (HP:0001538)2.96083459
66Encephalitis (HP:0002383)2.95331681
67Progressive muscle weakness (HP:0003323)2.94383174
68Epileptiform EEG discharges (HP:0011182)2.94369507
69Micronodular cirrhosis (HP:0001413)2.92409923
70Progressive neurologic deterioration (HP:0002344)2.85583969
71Hypercortisolism (HP:0001578)2.85113020
72Hemoptysis (HP:0002105)2.84630553
73Glomerulonephritis (HP:0000099)2.80475115
74Oligomenorrhea (HP:0000876)2.79180878
75Hematochezia (HP:0002573)2.78915208
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.78814303
77Purpura (HP:0000979)2.78759876
78Abnormal autonomic nervous system physiology (HP:0012332)2.78669168
79Hypokalemia (HP:0002900)2.76040679
80Joint swelling (HP:0001386)2.72645186
81Decreased lacrimation (HP:0000633)2.72031522
82Agitation (HP:0000713)2.70662418
83Petechiae (HP:0000967)2.70035973
84Increased serum ferritin (HP:0003281)2.67306819
85Anorexia (HP:0002039)2.66147720
86Polyneuropathy (HP:0001271)2.66117341
87Hypoplastic ischia (HP:0003175)2.64020603
88Dysautonomia (HP:0002459)2.63454826
89Hypotension (HP:0002615)2.62215320
90Gout (HP:0001997)2.58979707
91Abnormality of renin-angiotensin system (HP:0000847)2.57128647
92Hyperactive renin-angiotensin system (HP:0000841)2.55279658
93Hypergammaglobulinemia (HP:0010702)2.55155507
94Hypoplastic pelvis (HP:0008839)2.53557451
95Amyloidosis (HP:0011034)2.52661296
96Abnormality of urine glucose concentration (HP:0011016)2.51683981
97Glycosuria (HP:0003076)2.51683981
98Abnormality of the pleura (HP:0002103)2.50558237
99Increased IgE level (HP:0003212)2.49024419
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47163078
101Basal ganglia calcification (HP:0002135)2.46480214
102Recurrent fungal infections (HP:0002841)2.45926137
103Recurrent viral infections (HP:0004429)2.45537343
104Vertigo (HP:0002321)2.45332364
105Autoimmune hemolytic anemia (HP:0001890)2.44411723
106Axonal loss (HP:0003447)2.43419064
107Aplasia/hypoplasia of the uterus (HP:0008684)2.43206642
108Abnormality of vitamin B metabolism (HP:0004340)2.40979155
109Chronic obstructive pulmonary disease (HP:0006510)2.40760864
110Obstructive lung disease (HP:0006536)2.40760864
111Episodic fever (HP:0001954)2.40461269
112Meningitis (HP:0001287)2.40097618
113Gastrointestinal infarctions (HP:0005244)2.37334178
114Abnormality of the ischium (HP:0003174)2.36231325
115Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35333843
116Neurofibrillary tangles (HP:0002185)2.34620310
117Acne (HP:0001061)2.34188685
118Abnormality of the pericardium (HP:0001697)2.33497405
119Osteomalacia (HP:0002749)2.33019899
120Pulmonary embolism (HP:0002204)2.32332014
121Recurrent skin infections (HP:0001581)2.31228172
122Keratitis (HP:0000491)2.30792673
123Nausea (HP:0002018)2.29222514
124Inappropriate behavior (HP:0000719)2.28796751
125Abnormality of the vitamin B12 metabolism (HP:0004341)2.24880442
126Apathy (HP:0000741)2.24731383
127Abnormality of iron homeostasis (HP:0011031)2.22151953
128T lymphocytopenia (HP:0005403)2.21960919
129Gingivitis (HP:0000230)2.21249098
130Hepatosplenomegaly (HP:0001433)2.19388391
131Ketosis (HP:0001946)2.18348601
132Prolonged QT interval (HP:0001657)2.17457355
133Abnormality of vitamin metabolism (HP:0100508)2.16736321
134Leukocytosis (HP:0001974)2.16198019
135Diminished motivation (HP:0000745)2.15403100
136Failure to thrive in infancy (HP:0001531)2.14924124
137Adrenal overactivity (HP:0002717)2.14416856
138Abnormal auditory evoked potentials (HP:0006958)2.14170025
139Pheochromocytoma (HP:0002666)2.13814819
140Abnormality of T cell number (HP:0011839)2.12290469
141Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11854593
142Intrahepatic cholestasis (HP:0001406)2.11252790
143Glomerulopathy (HP:0100820)2.11185049
144Memory impairment (HP:0002354)2.10046190
145Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09609630
146Abnormality of the intrinsic pathway (HP:0010989)2.09034926
147Abnormality of potassium homeostasis (HP:0011042)2.03709499
148Centrally nucleated skeletal muscle fibers (HP:0003687)2.03416310
149Arthralgia (HP:0002829)2.02468700
150Abnormality of lateral ventricle (HP:0030047)2.02203131
151Abnormality of the endocardium (HP:0004306)2.02093321
152Prolonged bleeding time (HP:0003010)2.01142792
153Hyperphosphaturia (HP:0003109)2.00746208
154Complement deficiency (HP:0004431)2.00354274
155Abnormal sex determination (HP:0012244)1.99837178
156Sex reversal (HP:0012245)1.99837178
157Abnormal protein glycosylation (HP:0012346)1.97448820
158Abnormal glycosylation (HP:0012345)1.97448820
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97448820
160Abnormal protein N-linked glycosylation (HP:0012347)1.97448820
161IgA deficiency (HP:0002720)1.96234878
162Neuroendocrine neoplasm (HP:0100634)1.95599481
163Urticaria (HP:0001025)1.94517635
164Abnormality of B cell number (HP:0010975)1.94257989
165Increased circulating renin level (HP:0000848)1.93771895
166Agnosia (HP:0010524)1.93613481
167Abnormal foot bone ossification (HP:0010675)1.91978790
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91254301
169Anhidrosis (HP:0000970)1.90639047
170Retinal atrophy (HP:0001105)1.88428511
171Neuronal loss in central nervous system (HP:0002529)1.88387975
172Cortical visual impairment (HP:0100704)1.84110202
173Fat malabsorption (HP:0002630)1.83762051
174Bradycardia (HP:0001662)1.83184990
175Global brain atrophy (HP:0002283)1.82426545
176Abnormality of transition element cation homeostasis (HP:0011030)1.81474819
177Myocardial infarction (HP:0001658)1.80683614
178Malnutrition (HP:0004395)1.80324212
179Irritability (HP:0000737)1.79545075
180Back pain (HP:0003418)1.79321722
181Chronic bronchitis (HP:0004469)1.78508170
182Syncope (HP:0001279)1.78239705
183Hypokalemic alkalosis (HP:0001949)1.77469830
184Abnormality of liposaccharide metabolism (HP:0010968)1.76274556
185Abnormality of glycosphingolipid metabolism (HP:0004343)1.76274556
186Abnormality of glycolipid metabolism (HP:0010969)1.76274556
187Disproportionate short-trunk short stature (HP:0003521)1.71976786
188Hyperkalemia (HP:0002153)1.69472579
189Xanthomatosis (HP:0000991)1.69445281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.33989678
2PASK4.79531506
3NME14.56533372
4FRK4.32127554
5INSRR3.68543964
6MAP3K143.14812182
7TAOK33.11585006
8TAOK23.11045820
9RPS6KB23.09342363
10IRAK42.96257885
11RIPK42.93226737
12RIPK12.89722715
13TBK12.85379231
14IKBKE2.52443348
15TYK22.48712190
16MAP3K22.30112680
17IKBKB2.26741023
18ERN12.24508479
19PIM22.22364253
20MOS2.20349186
21HIPK22.10469452
22TXK2.01384803
23AKT31.96543882
24DDR21.96145544
25BMPR21.92057931
26NTRK11.88859363
27TEC1.84057719
28MAP3K31.82289506
29MAP2K31.73703509
30JAK31.66719062
31TGFBR21.64142696
32FGR1.62133352
33STK241.61230213
34SCYL21.60075512
35UHMK11.58549674
36PNCK1.55211671
37MAP3K61.42758915
38JAK11.39849680
39MAP3K11.39625661
40MAP2K21.37041960
41IRAK11.34674619
42CAMK2D1.34059930
43ZAP701.33515998
44TESK11.33388227
45ADRBK21.33281899
46CDC42BPA1.30265091
47CHUK1.29817908
48CSK1.29606616
49PTK61.26952661
50WNK41.25334095
51LIMK11.23576933
52LYN1.19680008
53SYK1.17755437
54CLK11.13972862
55MAP3K51.13515477
56STK101.10207436
57GRK51.09137472
58CAMK2B1.07989663
59ICK1.07722684
60CSNK1G31.00880273
61BTK0.98318926
62MAP2K60.94820148
63DYRK30.93750450
64MST40.91377885
65CSF1R0.88400321
66HCK0.88122245
67CSNK1A1L0.87975984
68PRKD20.87712003
69TAOK10.85429842
70MET0.84534414
71EPHB10.84076396
72LCK0.82050069
73CSNK1G20.80427784
74MAP2K10.79151464
75PAK60.78562517
76MAP3K110.78392308
77LATS20.76703090
78PIM10.76617983
79BMX0.75633954
80PKN10.73060761
81MARK20.72854309
82PRKCI0.72277033
83PTK20.72180205
84PAK30.70325564
85DYRK1B0.70323388
86TRIB30.70035917
87KSR20.69463606
88ABL20.68540962
89CSNK1A10.67507166
90TNK20.65609710
91DAPK20.65566404
92ITK0.65231798
93FES0.63899000
94NTRK30.63891096
95MARK30.63766089
96PRKCE0.62041896
97ACVR1B0.62018273
98GRK70.61570415
99CSNK1G10.61471298
100WNK10.61230285
101CDK120.61120528
102MAP3K130.60424558
103CAMK2G0.59869927
104BLK0.58053721
105NME20.57575289
106MAPKAPK50.55373748
107BCR0.54278636
108PRKCH0.53619396
109CAMK10.52946322
110MAP3K70.52815985
111BRD40.52614945
112SIK30.52370799
113BRAF0.50493921
114ADRBK10.49400362
115WNK30.47262188
116MAPK40.46219745
117IRAK30.44504482
118PRPF4B0.43880222
119OXSR10.41191297
120PDK10.41019409
121TYRO30.40334899
122CDK60.39587131
123RPS6KB10.38584428
124LATS10.38272105
125DAPK30.36808617
126NUAK10.36763953
127MAPK70.36420307
128ILK0.35657681
129KIT0.35386744
130EIF2AK30.33942785
131IRAK20.33927508
132STK390.33791582
133MATK0.32793451
134PRKCQ0.32472518
135RET0.31793323
136PIK3CA0.30883192
137PDGFRA0.30460513
138ALK0.30169706
139DYRK20.29837259
140FGFR40.29076568
141TLK10.29048010
142EIF2AK20.28720871
143FGFR30.28643593
144PRKACA0.28582104
145CDK190.28565961
146EGFR0.28096218
147FYN0.27952915
148ABL10.27852901
149INSR0.27492952
150RPS6KA20.26594757
151MAPKAPK20.25675123
152PRKAA10.24652863
153RPS6KC10.23566018
154RPS6KL10.23566018
155JAK20.23425759
156EPHA30.23307489
157TESK20.23110685
158PDPK10.22119025
159PAK10.21982012
160PRKD30.21849065
161SIK10.21126777
162SIK20.20996488
163GSK3A0.20807216
164CDK50.20538837
165PRKCA0.20413938
166CAMK2A0.20040934
167YES10.20022189
168CSNK1E0.19231113
169PRKCD0.18789793
170MAP4K10.18737670
171PKN20.17642207
172RPS6KA60.17630728
173PRKDC0.17226253
174FLT30.16464745

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.55151475
2Protein export_Homo sapiens_hsa030604.58189176
3Sulfur metabolism_Homo sapiens_hsa009204.40540811
4Linoleic acid metabolism_Homo sapiens_hsa005913.87782326
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.71119556
6Toll-like receptor signaling pathway_Homo sapiens_hsa046203.22435434
7Fat digestion and absorption_Homo sapiens_hsa049752.86542043
8Osteoclast differentiation_Homo sapiens_hsa043802.79934154
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.77863223
10Allograft rejection_Homo sapiens_hsa053302.72553594
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.70482007
12Asthma_Homo sapiens_hsa053102.67200456
13Malaria_Homo sapiens_hsa051442.66293042
14Leishmaniasis_Homo sapiens_hsa051402.59310121
15Insulin secretion_Homo sapiens_hsa049112.57179851
16Staphylococcus aureus infection_Homo sapiens_hsa051502.55169905
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.51858878
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.45304902
19African trypanosomiasis_Homo sapiens_hsa051432.41595191
20Rheumatoid arthritis_Homo sapiens_hsa053232.40850031
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.39101746
22TNF signaling pathway_Homo sapiens_hsa046682.38294091
23Vibrio cholerae infection_Homo sapiens_hsa051102.34767216
24Ether lipid metabolism_Homo sapiens_hsa005652.25094199
25Pertussis_Homo sapiens_hsa051332.24546573
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19321593
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16956553
28Graft-versus-host disease_Homo sapiens_hsa053322.16146956
29Intestinal immune network for IgA production_Homo sapiens_hsa046722.14991120
30Legionellosis_Homo sapiens_hsa051342.12647235
31Autoimmune thyroid disease_Homo sapiens_hsa053202.05968710
32Tuberculosis_Homo sapiens_hsa051521.96810361
33Pancreatic secretion_Homo sapiens_hsa049721.91255431
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.85992120
35Type II diabetes mellitus_Homo sapiens_hsa049301.84302512
36Influenza A_Homo sapiens_hsa051641.83619351
37Arachidonic acid metabolism_Homo sapiens_hsa005901.71779576
38Salmonella infection_Homo sapiens_hsa051321.68590594
39Selenocompound metabolism_Homo sapiens_hsa004501.66108166
40Measles_Homo sapiens_hsa051621.63643445
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62709760
42Toxoplasmosis_Homo sapiens_hsa051451.60101206
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.59524956
44Hematopoietic cell lineage_Homo sapiens_hsa046401.50155618
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47001695
46Herpes simplex infection_Homo sapiens_hsa051681.41795059
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41085397
48Cocaine addiction_Homo sapiens_hsa050301.33569054
49Oxidative phosphorylation_Homo sapiens_hsa001901.28072802
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26032031
51Chemokine signaling pathway_Homo sapiens_hsa040621.21090272
52B cell receptor signaling pathway_Homo sapiens_hsa046621.19364390
53Galactose metabolism_Homo sapiens_hsa000521.18550684
54Type I diabetes mellitus_Homo sapiens_hsa049401.17640288
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13687726
56Antigen processing and presentation_Homo sapiens_hsa046121.11454754
57Taste transduction_Homo sapiens_hsa047421.10193648
58Hepatitis B_Homo sapiens_hsa051611.08995144
59Lysosome_Homo sapiens_hsa041421.08826007
60Primary immunodeficiency_Homo sapiens_hsa053401.07731354
61N-Glycan biosynthesis_Homo sapiens_hsa005101.07142570
62Alzheimers disease_Homo sapiens_hsa050101.03403357
63Viral myocarditis_Homo sapiens_hsa054161.02447757
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.01273789
65Other glycan degradation_Homo sapiens_hsa005111.01240692
66Butanoate metabolism_Homo sapiens_hsa006501.00792231
67Phagosome_Homo sapiens_hsa041451.00446999
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00200420
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.98751469
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.97433466
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96978879
72Shigellosis_Homo sapiens_hsa051310.95211283
73Amoebiasis_Homo sapiens_hsa051460.95152013
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95000815
75T cell receptor signaling pathway_Homo sapiens_hsa046600.93764418
76Amphetamine addiction_Homo sapiens_hsa050310.91584755
77Parkinsons disease_Homo sapiens_hsa050120.91117456
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90915238
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89923503
80Acute myeloid leukemia_Homo sapiens_hsa052210.85973618
81Apoptosis_Homo sapiens_hsa042100.84792531
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.84562559
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83092279
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81852411
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81434990
86Collecting duct acid secretion_Homo sapiens_hsa049660.81019669
87Histidine metabolism_Homo sapiens_hsa003400.80765011
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80662620
89Tyrosine metabolism_Homo sapiens_hsa003500.79215663
90Phenylalanine metabolism_Homo sapiens_hsa003600.78841916
91Tryptophan metabolism_Homo sapiens_hsa003800.77359161
92Synaptic vesicle cycle_Homo sapiens_hsa047210.76727458
93Serotonergic synapse_Homo sapiens_hsa047260.75432898
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75010796
95Epstein-Barr virus infection_Homo sapiens_hsa051690.73581753
96PPAR signaling pathway_Homo sapiens_hsa033200.70314291
97Cholinergic synapse_Homo sapiens_hsa047250.70070239
98Folate biosynthesis_Homo sapiens_hsa007900.69472439
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68968501
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68030165
101Proteasome_Homo sapiens_hsa030500.67971249
102Bladder cancer_Homo sapiens_hsa052190.67620838
103Dopaminergic synapse_Homo sapiens_hsa047280.66144366
104ABC transporters_Homo sapiens_hsa020100.63814184
105Bile secretion_Homo sapiens_hsa049760.63613253
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62511839
107Complement and coagulation cascades_Homo sapiens_hsa046100.62124294
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59281482
109VEGF signaling pathway_Homo sapiens_hsa043700.58364589
110Fructose and mannose metabolism_Homo sapiens_hsa000510.56554655
111Steroid biosynthesis_Homo sapiens_hsa001000.51888647
112Prion diseases_Homo sapiens_hsa050200.50017103
113Huntingtons disease_Homo sapiens_hsa050160.48861296
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.47473600
115Dorso-ventral axis formation_Homo sapiens_hsa043200.46882932
116GABAergic synapse_Homo sapiens_hsa047270.45475165
117Starch and sucrose metabolism_Homo sapiens_hsa005000.44176977
118Glucagon signaling pathway_Homo sapiens_hsa049220.43668791
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43500016
120Thyroid cancer_Homo sapiens_hsa052160.43151705
121Thyroid hormone synthesis_Homo sapiens_hsa049180.42469871
122Renin secretion_Homo sapiens_hsa049240.42245204
123Long-term potentiation_Homo sapiens_hsa047200.42240079
124Estrogen signaling pathway_Homo sapiens_hsa049150.40431818
125Protein digestion and absorption_Homo sapiens_hsa049740.39400696
126Insulin resistance_Homo sapiens_hsa049310.38260813
127HTLV-I infection_Homo sapiens_hsa051660.38260704
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36807200
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36243149
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.36018538
131Cardiac muscle contraction_Homo sapiens_hsa042600.35097204
132Ras signaling pathway_Homo sapiens_hsa040140.34910756
133Alcoholism_Homo sapiens_hsa050340.34895658
134Insulin signaling pathway_Homo sapiens_hsa049100.34121458
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33322271
136Systemic lupus erythematosus_Homo sapiens_hsa053220.33290878
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33205648
138Platelet activation_Homo sapiens_hsa046110.32908195
139FoxO signaling pathway_Homo sapiens_hsa040680.31890734
140Long-term depression_Homo sapiens_hsa047300.31702353
141Notch signaling pathway_Homo sapiens_hsa043300.31332504
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30340427
143Prolactin signaling pathway_Homo sapiens_hsa049170.29432618
144Viral carcinogenesis_Homo sapiens_hsa052030.29341854
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.29205316
146Gap junction_Homo sapiens_hsa045400.29031028
147Circadian rhythm_Homo sapiens_hsa047100.28898779
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28852264
149HIF-1 signaling pathway_Homo sapiens_hsa040660.28584572
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28126378
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27112002
152Renin-angiotensin system_Homo sapiens_hsa046140.26342848
153Circadian entrainment_Homo sapiens_hsa047130.25413006
154Chronic myeloid leukemia_Homo sapiens_hsa052200.24348897
155Endocytosis_Homo sapiens_hsa041440.24018926
156MAPK signaling pathway_Homo sapiens_hsa040100.23851679
157Glutamatergic synapse_Homo sapiens_hsa047240.21782583
158GnRH signaling pathway_Homo sapiens_hsa049120.20783759
159Pancreatic cancer_Homo sapiens_hsa052120.18364902
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17237861
161Metabolic pathways_Homo sapiens_hsa011000.16590260
162Renal cell carcinoma_Homo sapiens_hsa052110.15847039
163Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15821250
164cAMP signaling pathway_Homo sapiens_hsa040240.15001006
165Tight junction_Homo sapiens_hsa045300.14987771
166Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14199635
167Arginine and proline metabolism_Homo sapiens_hsa003300.13279366
168Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13144709
169Sphingolipid metabolism_Homo sapiens_hsa006000.11013296
170Regulation of autophagy_Homo sapiens_hsa041400.10806817
171Phospholipase D signaling pathway_Homo sapiens_hsa040720.10572860
172Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10292853
173Hepatitis C_Homo sapiens_hsa051600.10267584
174Small cell lung cancer_Homo sapiens_hsa052220.08243587

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