FFAR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.58624272
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.70976279
3negative regulation of cell killing (GO:0031342)6.70976279
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.67883619
5sequestering of metal ion (GO:0051238)6.26693807
6positive regulation by symbiont of host defense response (GO:0052509)6.26529266
7modulation by symbiont of host defense response (GO:0052031)6.26529266
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.26529266
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.26529266
10positive regulation by organism of defense response of other organism involved in symbiotic interact6.26529266
11modulation by symbiont of host immune response (GO:0052553)6.26529266
12positive regulation of gamma-delta T cell activation (GO:0046645)5.55498376
13central nervous system myelination (GO:0022010)5.29934770
14axon ensheathment in central nervous system (GO:0032291)5.29934770
15detection of other organism (GO:0098543)5.24766883
16macrophage activation involved in immune response (GO:0002281)5.17435711
17protein maturation by protein folding (GO:0022417)5.07840705
18endocrine pancreas development (GO:0031018)5.02959575
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.99367717
20detection of bacterium (GO:0016045)4.96149271
21regulation of B cell receptor signaling pathway (GO:0050855)4.94724771
22detection of molecule of bacterial origin (GO:0032490)4.87525069
23detection of external biotic stimulus (GO:0098581)4.67365425
24response to interleukin-15 (GO:0070672)4.67239941
25negative regulation of interleukin-12 production (GO:0032695)4.66469799
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.66188398
27response to peptidoglycan (GO:0032494)4.65351875
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.59274243
29regulation of interferon-beta biosynthetic process (GO:0045357)4.52892921
30COPI coating of Golgi vesicle (GO:0048205)4.51343760
31Golgi transport vesicle coating (GO:0048200)4.51343760
32neutrophil activation (GO:0042119)4.49372501
33cellular extravasation (GO:0045123)4.48217943
34nucleotide transmembrane transport (GO:1901679)4.45779558
35cellular response to interleukin-15 (GO:0071350)4.39665631
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35143544
37type I interferon signaling pathway (GO:0060337)4.32067866
38cellular response to type I interferon (GO:0071357)4.32067866
39response to type I interferon (GO:0034340)4.30357400
40response to host immune response (GO:0052572)4.29131697
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.29131697
42microglial cell activation (GO:0001774)4.24679267
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.13951851
44immunoglobulin mediated immune response (GO:0016064)4.12769506
45detection of biotic stimulus (GO:0009595)4.12404579
46peptide hormone processing (GO:0016486)4.10106580
47negative regulation of execution phase of apoptosis (GO:1900118)4.06072070
48regulation of gamma-delta T cell activation (GO:0046643)4.05450616
49granulocyte activation (GO:0036230)3.99863016
50ER overload response (GO:0006983)3.93060964
51negative regulation of leukocyte mediated immunity (GO:0002704)3.92956670
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86848834
53response to host (GO:0075136)3.86848834
54response to host defenses (GO:0052200)3.86848834
55macrophage activation (GO:0042116)3.83543297
56cellular response to zinc ion (GO:0071294)3.74925651
57negative regulation of T cell mediated immunity (GO:0002710)3.74720040
58positive regulation of oligodendrocyte differentiation (GO:0048714)3.72958006
59myeloid cell activation involved in immune response (GO:0002275)3.70546809
60positive regulation of cell fate commitment (GO:0010455)3.62811263
61response to dietary excess (GO:0002021)3.59116295
62GPI anchor biosynthetic process (GO:0006506)3.59100395
63response to interferon-alpha (GO:0035455)3.56886030
64antigen processing and presentation via MHC class Ib (GO:0002475)3.52776759
65myeloid leukocyte mediated immunity (GO:0002444)3.52657476
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.52305114
67negative regulation of T-helper cell differentiation (GO:0045623)3.52305114
68regulation of mast cell degranulation (GO:0043304)3.50979057
69neutrophil activation involved in immune response (GO:0002283)3.49723019
70germinal center formation (GO:0002467)3.45603175
71interferon-gamma-mediated signaling pathway (GO:0060333)3.45543833
72glandular epithelial cell differentiation (GO:0002067)3.44761183
73COPII vesicle coating (GO:0048208)3.44696184
74regulation of T cell mediated cytotoxicity (GO:0001914)3.44625443
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44561656
76regulation of type B pancreatic cell apoptotic process (GO:2000674)3.44261056
77fatty acid elongation (GO:0030497)3.43552130
78defense response to protozoan (GO:0042832)3.42603477
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39322024
80positive regulation of mast cell activation (GO:0033005)3.37173613
81positive regulation of interferon-alpha production (GO:0032727)3.36894384
82regulation of gamma-delta T cell differentiation (GO:0045586)3.36665634
83regulation of mast cell activation (GO:0033003)3.35353120
84dendritic cell migration (GO:0036336)3.31882513
85dendritic cell chemotaxis (GO:0002407)3.29135286
86fucosylation (GO:0036065)3.28208508
87regulation of mast cell activation involved in immune response (GO:0033006)3.28066900
88B cell mediated immunity (GO:0019724)3.27860297
89GPI anchor metabolic process (GO:0006505)3.26968879
90activated T cell proliferation (GO:0050798)3.25178016
91B cell receptor signaling pathway (GO:0050853)3.24636428
92negative regulation of JUN kinase activity (GO:0043508)3.23191707
93regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23005070
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22953924
95negative regulation of alpha-beta T cell activation (GO:0046636)3.22498370
96fucose metabolic process (GO:0006004)3.22097537
97regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.21442360
98regulation of T cell tolerance induction (GO:0002664)3.20934724
99regulation of interferon-alpha production (GO:0032647)3.18869953
100positive regulation of insulin secretion (GO:0032024)3.18156899
101preassembly of GPI anchor in ER membrane (GO:0016254)3.16435142
102mannosylation (GO:0097502)3.11767509
103regulation of tolerance induction (GO:0002643)3.11572646
104regulation of T-helper 2 cell differentiation (GO:0045628)3.11349835
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10363777
106regulation of natural killer cell mediated immunity (GO:0002715)3.10363777
107negative regulation of innate immune response (GO:0045824)3.09865947
108respiratory burst (GO:0045730)3.09475616
109positive regulation of toll-like receptor signaling pathway (GO:0034123)3.09182364
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09053337
111regulation of cytokine production involved in inflammatory response (GO:1900015)3.09008059
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08248609
113regulation of regulatory T cell differentiation (GO:0045589)3.07544011
114regulation of B cell differentiation (GO:0045577)3.05577566
115leukocyte aggregation (GO:0070486)3.04301685
116positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02903367
117negative regulation of type 2 immune response (GO:0002829)3.02041593
118negative regulation of interleukin-6 production (GO:0032715)3.00323827
119* leukocyte migration involved in inflammatory response (GO:0002523)3.00314404
120tolerance induction (GO:0002507)3.00276370
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99510371
122neutrophil chemotaxis (GO:0030593)2.97631268
123response to protozoan (GO:0001562)2.97554777
124production of molecular mediator involved in inflammatory response (GO:0002532)2.97364945
125interferon-gamma secretion (GO:0072643)2.96910168
126intracellular pH reduction (GO:0051452)2.93625365
127magnesium ion transport (GO:0015693)2.92635595
128negative regulation of phagocytosis (GO:0050765)2.89187782
129negative regulation of glycoprotein biosynthetic process (GO:0010561)2.88247460
130positive regulation of cellular amine metabolic process (GO:0033240)2.87731051
131positive regulation of defense response to virus by host (GO:0002230)2.84025059
132telomere maintenance via telomerase (GO:0007004)2.83185196
133regulation of lipoprotein metabolic process (GO:0050746)2.83179957
134negative regulation of interleukin-10 production (GO:0032693)2.81177996
135C-terminal protein lipidation (GO:0006501)2.79242060
136response to lipoprotein particle (GO:0055094)2.79240567
137defense response to fungus (GO:0050832)2.78312653
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77982220
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77982220
140negative regulation of bone resorption (GO:0045779)2.77849131
141cotranslational protein targeting to membrane (GO:0006613)2.77514402
142GDP-mannose metabolic process (GO:0019673)2.76686476
143nucleoside diphosphate catabolic process (GO:0009134)2.76339140
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.74820574
145neutrophil mediated immunity (GO:0002446)2.74086062
146protein targeting to ER (GO:0045047)2.74048140
147response to redox state (GO:0051775)2.73022350
148glycosylceramide metabolic process (GO:0006677)2.72942408
149long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.72888686
150long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72512893
151SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72212971
152auditory receptor cell differentiation (GO:0042491)2.71844527
153oligodendrocyte differentiation (GO:0048709)2.71475067
1543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.71325626
155purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.71325626
156antigen processing and presentation of endogenous antigen (GO:0019883)2.70326652
157negative regulation of transcription by competitive promoter binding (GO:0010944)2.69958029
158leukocyte degranulation (GO:0043299)2.69117072
159photoreceptor cell differentiation (GO:0046530)2.68908625
160eye photoreceptor cell differentiation (GO:0001754)2.68908625
161pH reduction (GO:0045851)2.68521926
162modulation of growth of symbiont involved in interaction with host (GO:0044144)2.68483924
163regulation of growth of symbiont in host (GO:0044126)2.68483924
164negative regulation of growth of symbiont in host (GO:0044130)2.68483924
165negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68483924
166nucleotide transport (GO:0006862)2.65841235
167establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65485706
168interleukin-1-mediated signaling pathway (GO:0070498)2.64070493
169fatty-acyl-CoA metabolic process (GO:0035337)2.63352664
170protein localization to endoplasmic reticulum (GO:0070972)2.62379070
171negative regulation of myotube differentiation (GO:0010832)2.61393356
172adaptation of signaling pathway (GO:0023058)2.60756709
173axon ensheathment (GO:0008366)2.58195382
174ensheathment of neurons (GO:0007272)2.58195382
175killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.57418514
176disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.57418514
177myelination (GO:0042552)2.56363974
178positive regulation of steroid hormone secretion (GO:2000833)2.55352297
179positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.53504589
180regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51843474
181regulation of vacuole organization (GO:0044088)2.51361305
182negative regulation of neurotransmitter secretion (GO:0046929)2.48583250
183positive regulation of peptide hormone secretion (GO:0090277)2.48195909
184regulation of autophagic vacuole assembly (GO:2000785)2.46929546
185viral protein processing (GO:0019082)2.44583266
186replicative senescence (GO:0090399)2.43368834
187ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.42407363
188regulation of insulin secretion (GO:0050796)2.41861131
189amyloid precursor protein catabolic process (GO:0042987)2.41741718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31172209
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.05835643
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.78846948
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.20217206
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09552804
6SCL_19346495_ChIP-Seq_HPC-7_Human3.07726726
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05847663
8* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.90174275
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.80666236
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68987983
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51043303
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48111793
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48000964
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46306202
15MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.45608795
16GATA1_22025678_ChIP-Seq_K562_Human2.44910952
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.42847803
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39973064
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25827652
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24065436
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.21867695
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17861317
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17142178
24MAF_26560356_Chip-Seq_TH1_Human2.16086183
25ERG_20887958_ChIP-Seq_HPC-7_Mouse2.14847850
26SPI1_23547873_ChIP-Seq_NB4_Human2.11197244
27VDR_24763502_ChIP-Seq_THP-1_Human2.03619765
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99499619
29* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93969797
30UTX_26944678_Chip-Seq_JUKART_Human1.93090557
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87604754
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83969663
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.78288790
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76961350
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71084895
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70566161
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70096640
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.69458083
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67478368
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64794386
41GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.63106742
42VDR_21846776_ChIP-Seq_THP-1_Human1.62186892
43MAF_26560356_Chip-Seq_TH2_Human1.59852870
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59802900
45MYB_26560356_Chip-Seq_TH2_Human1.58039565
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51203296
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50643186
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46269846
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45782830
50* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43859403
51MYC_22102868_ChIP-Seq_BL_Human1.41951223
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40162103
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.39977926
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.38622395
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36512872
56* GATA3_26560356_Chip-Seq_TH2_Human1.35267158
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.34061769
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34056137
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33546583
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33377507
61IRF1_19129219_ChIP-ChIP_H3396_Human1.32963318
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32752504
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32284098
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32116293
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30428579
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30354420
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30208328
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29381563
69KDM2B_26808549_Chip-Seq_DND41_Human1.29137439
70RUNX_20019798_ChIP-Seq_JUKART_Human1.28798155
71* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28074849
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25152652
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22664509
74GATA1_19941826_ChIP-Seq_K562_Human1.21598261
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20378578
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20128967
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19517912
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19087802
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17705109
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17418530
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17243972
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16254579
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16108108
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15527200
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14317390
86MYB_26560356_Chip-Seq_TH1_Human1.13319660
87FOXP3_21729870_ChIP-Seq_TREG_Human1.10470665
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.09665913
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09583433
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09280480
91BCL6_27268052_Chip-Seq_Bcells_Human1.07936493
92STAT1_20625510_ChIP-Seq_HELA_Human1.07916178
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07282202
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07239217
95ERG_20517297_ChIP-Seq_VCAP_Human1.07122102
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06840849
97ETS1_22383799_ChIP-Seq_G1ME_Mouse1.05659827
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.03567422
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03047711
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02905700
101SPI1_23127762_ChIP-Seq_K562_Human1.02324285
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01659811
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01580267
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01369663
105PU_27001747_Chip-Seq_BMDM_Mouse1.01317072
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.01261376
107EST1_17652178_ChIP-ChIP_JURKAT_Human0.98301613
108WT1_19549856_ChIP-ChIP_CCG9911_Human0.97980512
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97296143
110ELK1_19687146_ChIP-ChIP_HELA_Human0.97223269
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.97089076
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.96970296
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96440137
114SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96439127
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95875298
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94563897
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.94076368
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93409700
119SMRT_27268052_Chip-Seq_Bcells_Human0.93097386
120VDR_23849224_ChIP-Seq_CD4+_Human0.92909463
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92589305
122BCOR_27268052_Chip-Seq_Bcells_Human0.90886733
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89496763
124RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89075563
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88743990
126* VDR_24787735_ChIP-Seq_THP-1_Human0.88558890
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87975190
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.87812307
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87719755
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87626534
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.86165663
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.85378888
133KLF4_18555785_Chip-Seq_ESCs_Mouse0.84993799
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84515921
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.84132881
136SPI1_20517297_ChIP-Seq_HL60_Human0.81066978
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78319340
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78288631
139GATA2_19941826_ChIP-Seq_K562_Human0.76533206
140* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74684551
141BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.74465911
142GATA3_26560356_Chip-Seq_TH1_Human0.73971833
143P300_27268052_Chip-Seq_Bcells_Human0.72067957
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69512268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue3.78838274
2MP0003183_abnormal_peptide_metabolism3.47397625
3MP0002877_abnormal_melanocyte_morpholog3.43205972
4MP0004043_abnormal_pH_regulation3.06545481
5MP0005379_endocrine/exocrine_gland_phen3.03625600
6MP0002693_abnormal_pancreas_physiology2.88306908
7MP0006082_CNS_inflammation2.70069822
8MP0000920_abnormal_myelination2.66298038
9MP0000003_abnormal_adipose_tissue2.49722780
10MP0001944_abnormal_pancreas_morphology2.46069488
11MP0001986_abnormal_taste_sensitivity2.37460066
12MP0002277_abnormal_respiratory_mucosa2.31969386
13MP0005645_abnormal_hypothalamus_physiol2.25312993
14* MP0001533_abnormal_skeleton_physiology2.14959454
15MP0005670_abnormal_white_adipose2.14760197
16MP0003191_abnormal_cellular_cholesterol2.08042582
17MP0005387_immune_system_phenotype2.04994194
18MP0001790_abnormal_immune_system2.04994194
19* MP0005000_abnormal_immune_tolerance2.01589466
20MP0003195_calcinosis2.00949603
21MP0008057_abnormal_DNA_replication1.98729403
22MP0005375_adipose_tissue_phenotype1.97879738
23MP0002132_abnormal_respiratory_system1.97396491
24MP0006072_abnormal_retinal_apoptosis1.95236440
25MP0002837_dystrophic_cardiac_calcinosis1.93037709
26MP0005220_abnormal_exocrine_pancreas1.91964106
27MP0002398_abnormal_bone_marrow1.88291940
28MP0003303_peritoneal_inflammation1.84799700
29MP0009764_decreased_sensitivity_to1.83535923
30MP0003763_abnormal_thymus_physiology1.83437550
31MP0002638_abnormal_pupillary_reflex1.83402011
32MP0001835_abnormal_antigen_presentation1.83370152
33MP0009785_altered_susceptibility_to1.80681879
34MP0005671_abnormal_response_to1.75795692
35MP0005058_abnormal_lysosome_morphology1.74008553
36MP0004185_abnormal_adipocyte_glucose1.71837227
37* MP0010155_abnormal_intestine_physiology1.71132013
38MP0002148_abnormal_hypersensitivity_rea1.68335660
39* MP0002419_abnormal_innate_immunity1.64906625
40MP0003283_abnormal_digestive_organ1.63359374
41MP0003300_gastrointestinal_ulcer1.63239516
42MP0009278_abnormal_bone_marrow1.62833036
43MP0010386_abnormal_urinary_bladder1.60274244
44MP0000689_abnormal_spleen_morphology1.57729797
45MP0003436_decreased_susceptibility_to1.54665023
46* MP0003724_increased_susceptibility_to1.54548637
47MP0002078_abnormal_glucose_homeostasis1.54431990
48MP0001661_extended_life_span1.54374926
49MP0002722_abnormal_immune_system1.53977419
50MP0004947_skin_inflammation1.53602346
51* MP0005025_abnormal_response_to1.52588496
52MP0002909_abnormal_adrenal_gland1.52553408
53MP0005666_abnormal_adipose_tissue1.50654229
54MP0005409_darkened_coat_color1.49880443
55MP0003828_pulmonary_edema1.48270466
56* MP0002429_abnormal_blood_cell1.44798232
57MP0000462_abnormal_digestive_system1.42349091
58MP0004883_abnormal_blood_vessel1.41216591
59* MP0002723_abnormal_immune_serum1.40242722
60MP0005075_abnormal_melanosome_morpholog1.39438135
61MP0009333_abnormal_splenocyte_physiolog1.37484466
62MP0002938_white_spotting1.35719670
63MP0000703_abnormal_thymus_morphology1.35413423
64* MP0002420_abnormal_adaptive_immunity1.30534431
65MP0000685_abnormal_immune_system1.29833837
66MP0003690_abnormal_glial_cell1.28541698
67MP0003136_yellow_coat_color1.27777996
68MP0000678_abnormal_parathyroid_gland1.27307518
69* MP0001819_abnormal_immune_cell1.27063064
70MP0003172_abnormal_lysosome_physiology1.25411511
71MP0004510_myositis1.24330903
72MP0008260_abnormal_autophagy1.23839655
73MP0001800_abnormal_humoral_immune1.21424962
74MP0003075_altered_response_to1.20639049
75MP0005310_abnormal_salivary_gland1.20402913
76MP0005174_abnormal_tail_pigmentation1.19292927
77MP0005451_abnormal_body_composition1.17947368
78MP0004381_abnormal_hair_follicle1.15083210
79MP0005408_hypopigmentation1.14878382
80MP0005164_abnormal_response_to1.14754679
81MP0002452_abnormal_antigen_presenting1.13373152
82* MP0003866_abnormal_defecation1.12156420
83MP0003950_abnormal_plasma_membrane1.12003439
84MP0003959_abnormal_lean_body1.11652946
85MP0000858_altered_metastatic_potential1.10860551
86MP0002876_abnormal_thyroid_physiology1.10751449
87MP0001545_abnormal_hematopoietic_system1.09506486
88MP0005397_hematopoietic_system_phenotyp1.09506486
89MP0001502_abnormal_circadian_rhythm1.08027989
90MP0005084_abnormal_gallbladder_morpholo1.05770932
91MP0002971_abnormal_brown_adipose1.04210434
92MP0001348_abnormal_lacrimal_gland1.03665208
93MP0003186_abnormal_redox_activity1.03571438
94MP0002138_abnormal_hepatobiliary_system1.01633600
95MP0002933_joint_inflammation1.00851937
96MP0001851_eye_inflammation1.00323652
97MP0000569_abnormal_digit_pigmentation0.99200761
98MP0002998_abnormal_bone_remodeling0.99027739
99* MP0001845_abnormal_inflammatory_respons0.98974172
100MP0000613_abnormal_salivary_gland0.97609331
101MP0005464_abnormal_platelet_physiology0.97122680
102MP0005452_abnormal_adipose_tissue0.96254303
103MP0003634_abnormal_glial_cell0.94828386
104* MP0000716_abnormal_immune_system0.94127528
105MP0005166_decreased_susceptibility_to0.92489631
106* MP0002405_respiratory_system_inflammati0.92464830
107MP0001663_abnormal_digestive_system0.91917105
108MP0005535_abnormal_body_temperature0.91635820
109MP0004742_abnormal_vestibular_system0.91332811
110MP0003045_fibrosis0.90768063
111MP0000015_abnormal_ear_pigmentation0.90745740
112MP0001765_abnormal_ion_homeostasis0.90529783
113MP0002166_altered_tumor_susceptibility0.90410270
114MP0005448_abnormal_energy_balance0.90121060
115MP0009643_abnormal_urine_homeostasis0.90026365
116MP0002396_abnormal_hematopoietic_system0.89413771
117MP0009780_abnormal_chondrocyte_physiolo0.88911036
118MP0005171_absent_coat_pigmentation0.87903324
119* MP0000465_gastrointestinal_hemorrhage0.87365277
120MP0004264_abnormal_extraembryonic_tissu0.86909911
121MP0006036_abnormal_mitochondrial_physio0.85311681
122MP0001485_abnormal_pinna_reflex0.85248203
123MP0000343_altered_response_to0.85221709
124* MP0008469_abnormal_protein_level0.82653037
125MP0001873_stomach_inflammation0.82465902
126MP0001905_abnormal_dopamine_level0.81999119
127* MP0005390_skeleton_phenotype0.81478213
128MP0003953_abnormal_hormone_level0.80916539
129MP0003806_abnormal_nucleotide_metabolis0.80654359
130MP0002653_abnormal_ependyma_morphology0.80653141
131* MP0002118_abnormal_lipid_homeostasis0.80568503
132MP0002928_abnormal_bile_duct0.80233271
133MP0000490_abnormal_crypts_of0.79990727
134MP0005253_abnormal_eye_physiology0.79388143
135MP0002095_abnormal_skin_pigmentation0.79130414
136* MP0009763_increased_sensitivity_to0.78819783
137MP0002970_abnormal_white_adipose0.77972529
138MP0008004_abnormal_stomach_pH0.77742162
139MP0005334_abnormal_fat_pad0.77268831
140MP0005377_hearing/vestibular/ear_phenot0.74863607
141MP0003878_abnormal_ear_physiology0.74863607
142MP0003448_altered_tumor_morphology0.73369677
143MP0003787_abnormal_imprinting0.70378307
144MP0004130_abnormal_muscle_cell0.67073321
145MP0002332_abnormal_exercise_endurance0.63520447
146MP0008874_decreased_physiological_sensi0.60694964
147MP0003221_abnormal_cardiomyocyte_apopto0.59630538
148MP0005319_abnormal_enzyme/_coenzyme0.59602277
149MP0005083_abnormal_biliary_tract0.59057776
150MP0002006_tumorigenesis0.58408561
151* MP0009765_abnormal_xenobiotic_induced0.57872866
152MP0003795_abnormal_bone_structure0.56136202
153MP0003252_abnormal_bile_duct0.55693830
154MP0003656_abnormal_erythrocyte_physiolo0.55689848
155MP0000604_amyloidosis0.53731439
156MP0004484_altered_response_of0.53324559
157MP0000470_abnormal_stomach_morphology0.52383957
158MP0001853_heart_inflammation0.51416452

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.71733891
2Recurrent gram-negative bacterial infections (HP:0005420)5.54513026
3Elevated erythrocyte sedimentation rate (HP:0003565)5.21843823
4Hypochromic microcytic anemia (HP:0004840)4.69493896
5Gastrointestinal infarctions (HP:0005244)4.66239157
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.50166322
7Hyperinsulinemic hypoglycemia (HP:0000825)4.48270644
8Keratoconjunctivitis sicca (HP:0001097)4.43741048
9Mediastinal lymphadenopathy (HP:0100721)4.43150597
10Recurrent fungal infections (HP:0002841)4.35916190
11Hypoglycemic coma (HP:0001325)4.32226021
12Keratoconjunctivitis (HP:0001096)4.22914848
13Symptomatic seizures (HP:0011145)4.15346986
14Hypoglycemic seizures (HP:0002173)4.15170595
15Encephalitis (HP:0002383)4.14854104
16Hypochromic anemia (HP:0001931)3.93906347
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.88689596
18Vasculitis (HP:0002633)3.80254375
19Chronic mucocutaneous candidiasis (HP:0002728)3.69734688
20Recurrent cutaneous fungal infections (HP:0011370)3.69734688
21Urticaria (HP:0001025)3.64160691
22Gingivitis (HP:0000230)3.59903730
23Type I transferrin isoform profile (HP:0003642)3.52014724
24Increased IgE level (HP:0003212)3.47933118
25Spontaneous hematomas (HP:0007420)3.46793133
26Hemoptysis (HP:0002105)3.32660665
27Generalized aminoaciduria (HP:0002909)3.32490289
28Chest pain (HP:0100749)3.26601854
29Peritonitis (HP:0002586)3.19896380
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.18558906
31Anorexia (HP:0002039)3.17316043
32Insulin-resistant diabetes mellitus (HP:0000831)3.16258703
33Large for gestational age (HP:0001520)3.15488767
34Dysostosis multiplex (HP:0000943)3.14955781
35Leukocytosis (HP:0001974)3.11003274
36Abnormality of calcium-phosphate metabolism (HP:0100530)3.05269594
37Abnormality of endocrine pancreas physiology (HP:0012093)3.03927359
38Abnormality of the pancreatic islet cells (HP:0006476)3.03927359
39Abnormal protein glycosylation (HP:0012346)3.03781011
40Abnormal glycosylation (HP:0012345)3.03781011
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03781011
42Abnormal protein N-linked glycosylation (HP:0012347)3.03781011
43Pancreatic islet-cell hyperplasia (HP:0004510)3.02594879
44Arterial thrombosis (HP:0004420)2.99119751
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.98516686
46Abnormality of T cell number (HP:0011839)2.98214061
47Vacuolated lymphocytes (HP:0001922)2.94270866
48Prolonged bleeding time (HP:0003010)2.93869079
49T lymphocytopenia (HP:0005403)2.92273255
50Cellulitis (HP:0100658)2.89402961
51Pulmonary embolism (HP:0002204)2.86252125
52Abnormality of T cell physiology (HP:0011840)2.85460751
53Progressive neurologic deterioration (HP:0002344)2.79204472
54Increased IgM level (HP:0003496)2.78446627
55Chronic otitis media (HP:0000389)2.71444042
56Microcytic anemia (HP:0001935)2.70085645
57Abnormality of the pleura (HP:0002103)2.68846193
58Gingival bleeding (HP:0000225)2.68338657
59Hepatic necrosis (HP:0002605)2.66684942
60Cortical visual impairment (HP:0100704)2.64411284
61Gangrene (HP:0100758)2.63107383
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57571762
63Recurrent abscess formation (HP:0002722)2.48882224
64Granulocytopenia (HP:0001913)2.47623954
65Inflammation of the large intestine (HP:0002037)2.47444854
66Meningitis (HP:0001287)2.47432904
67IgM deficiency (HP:0002850)2.47380039
68Pustule (HP:0200039)2.47061681
69Papilledema (HP:0001085)2.44166037
70Hypothermia (HP:0002045)2.42992591
71Osteomyelitis (HP:0002754)2.42970481
72Sepsis (HP:0100806)2.41994678
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40987038
74Hyperglycemia (HP:0003074)2.40175359
75Keratitis (HP:0000491)2.38198231
76Lymphopenia (HP:0001888)2.37318097
77Increased cerebral lipofuscin (HP:0011813)2.37309732
78Chronic obstructive pulmonary disease (HP:0006510)2.36776297
79Obstructive lung disease (HP:0006536)2.36776297
80Gastrointestinal inflammation (HP:0004386)2.36069887
81Urinary glycosaminoglycan excretion (HP:0003541)2.35999608
82Mucopolysacchariduria (HP:0008155)2.35999608
83Amyloidosis (HP:0011034)2.35710594
84Petechiae (HP:0000967)2.34473886
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30831241
86Epistaxis (HP:0000421)2.30011505
87Abnormality of the peritoneum (HP:0002585)2.29964925
88Abnormality of the endocardium (HP:0004306)2.29934782
89Recurrent bronchitis (HP:0002837)2.28818994
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28109314
91Abnormality of the pericardium (HP:0001697)2.28010285
92Eosinophilia (HP:0001880)2.27418318
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.26047181
94Reduced antithrombin III activity (HP:0001976)2.25503976
95Hypoplasia of the fovea (HP:0007750)2.23220432
96Aplasia/Hypoplasia of the fovea (HP:0008060)2.23220432
97Myositis (HP:0100614)2.21466894
98Retinal dysplasia (HP:0007973)2.16706387
99Hepatosplenomegaly (HP:0001433)2.16365685
100Hypergammaglobulinemia (HP:0010702)2.15968138
101Acute necrotizing encephalopathy (HP:0006965)2.14899716
102Panhypogammaglobulinemia (HP:0003139)2.14746980
103Parakeratosis (HP:0001036)2.14322604
104Recurrent bacterial skin infections (HP:0005406)2.11809127
105Decreased circulating renin level (HP:0003351)2.11795236
106Vertigo (HP:0002321)2.11637333
107Acute hepatic failure (HP:0006554)2.09460650
108Degeneration of the lateral corticospinal tracts (HP:0002314)2.08288770
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08288770
110Abnormal mitochondria in muscle tissue (HP:0008316)2.08135202
111Acne (HP:0001061)2.07504459
112Glomerulopathy (HP:0100820)2.07366188
113Stomach cancer (HP:0012126)2.07201859
114Optic neuritis (HP:0100653)2.06519389
115Retrobulbar optic neuritis (HP:0100654)2.06519389
116Premature graying of hair (HP:0002216)2.06448439
117Episodic fever (HP:0001954)2.06252544
118Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05726339
119Abnormality of polysaccharide metabolism (HP:0011012)2.05726339
120Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05726339
121Type II lissencephaly (HP:0007260)2.03150422
122Abnormality of eosinophils (HP:0001879)2.02113746
123Cheilitis (HP:0100825)2.01149030
124Menstrual irregularities (HP:0000858)2.00770078
125Hepatocellular necrosis (HP:0001404)2.00648462
126Recurrent pneumonia (HP:0006532)1.99849609
127Neurofibrillary tangles (HP:0002185)1.99845405
128Abnormal pancreas size (HP:0012094)1.99498462
129Abnormality of T cells (HP:0002843)1.99101957
130Toxemia of pregnancy (HP:0100603)1.98367831
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98282961
132Premature loss of primary teeth (HP:0006323)1.97428087
133Congenital sensorineural hearing impairment (HP:0008527)1.96389863
134Orchitis (HP:0100796)1.94532507
135Abnormal rod and cone electroretinograms (HP:0008323)1.94011666
1363-Methylglutaconic aciduria (HP:0003535)1.93225477
137Duplicated collecting system (HP:0000081)1.92963138
138Skin ulcer (HP:0200042)1.92915166
139Patchy hypopigmentation of hair (HP:0011365)1.92368163
140Abnormality of the fovea (HP:0000493)1.92277910
141Recurrent sinusitis (HP:0011108)1.91810412
142Abnormality of macrophages (HP:0004311)1.91226834
143Abnormality of the intrinsic pathway (HP:0010989)1.90602736
144Hyperparathyroidism (HP:0000843)1.89552163
145Ketoacidosis (HP:0001993)1.89548934
146Polyneuropathy (HP:0001271)1.89543818
147Eczematoid dermatitis (HP:0000976)1.89522901
148Acute encephalopathy (HP:0006846)1.88647717
149Abnormality of the heme biosynthetic pathway (HP:0010472)1.86865171
150White forelock (HP:0002211)1.86060203
151Abnormality of the renal collecting system (HP:0004742)1.85574974
152Recurrent viral infections (HP:0004429)1.85352175
153Rough bone trabeculation (HP:0100670)1.85294469
154Glycosuria (HP:0003076)1.84945804
155Abnormality of urine glucose concentration (HP:0011016)1.84945804
156Retinal atrophy (HP:0001105)1.84566105
157Recurrent skin infections (HP:0001581)1.84494044
158Abnormality of small intestinal villus morphology (HP:0011472)1.84386501
159Villous atrophy (HP:0011473)1.84386501
160Abnormality of iron homeostasis (HP:0011031)1.82663311
161Agammaglobulinemia (HP:0004432)1.82508760
162Anteriorly placed anus (HP:0001545)1.81976860
163Thrombocytosis (HP:0001894)1.81809793
164Insulin resistance (HP:0000855)1.81316450
165Slow saccadic eye movements (HP:0000514)1.80271192
166Pulmonary infiltrates (HP:0002113)1.79971345
167Gastrointestinal stroma tumor (HP:0100723)1.79709704
168Thyroid-stimulating hormone excess (HP:0002925)1.79162537
169Neutropenia (HP:0001875)1.78982662
170Skin rash (HP:0000988)1.78473518
171Neoplasm of the tracheobronchial system (HP:0100552)1.77832837
172Hypermelanotic macule (HP:0001034)1.77616462
173Alveolar cell carcinoma (HP:0006519)1.76956629
174Autoimmune hemolytic anemia (HP:0001890)1.73333601
175Recurrent lower respiratory tract infections (HP:0002783)1.72971440
176Nasal polyposis (HP:0100582)1.70444311
177Chronic sinusitis (HP:0011109)1.69855037
178Increased serum ferritin (HP:0003281)1.69412471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.51184776
2MAPK154.31163347
3STK163.29330065
4MAP2K32.99565912
5TYK22.90140704
6IRAK42.83554657
7PASK2.82856810
8TNK22.67578568
9TAOK32.62656835
10GRK62.36638447
11ERN12.31096637
12HIPK22.28450273
13EPHB12.26865827
14TXK2.22947948
15TEC2.21965450
16BLK2.16886174
17MAPKAPK52.10730229
18MAP4K12.09646877
19IRAK32.06004541
20TAOK11.98910370
21CDK191.95765627
22STK391.95058148
23EIF2AK31.78511506
24WNK41.78313915
25FGR1.74103922
26MAP3K111.70219101
27BTK1.68623287
28CLK11.63160798
29MAP3K31.62904387
30DYRK31.60626081
31FLT31.58119534
32TNIK1.57492756
33OXSR11.46483459
34UHMK11.45439052
35IRAK11.44526148
36BMPR1B1.31529026
37MUSK1.28162404
38SIK31.27465513
39YES11.24398665
40PIK3CG1.18664826
41KSR21.18631951
42MATK1.17100887
43ITK1.11565310
44CSK1.09545220
45MARK31.04939752
46IRAK21.00631334
47FES1.00148996
48VRK10.99740972
49PKN10.99585222
50PTK60.98491019
51MAP2K20.98461332
52FRK0.96409297
53SIK20.94634092
54BRSK20.91426900
55PRPF4B0.89805105
56PTK2B0.89586527
57MAP2K40.89577054
58TRPM70.89487781
59NTRK10.88964048
60MAP3K60.88156039
61JAK30.84494641
62KIT0.83480348
63CAMKK20.81534086
64GRK10.80764097
65SYK0.80736053
66LCK0.80685394
67CASK0.80063968
68PDK10.79655014
69STK110.79405228
70DAPK20.78433561
71RPS6KA50.77975319
72NEK60.76130371
73WNK30.75952554
74MAP2K60.73770468
75ZAP700.72291824
76MET0.72092597
77CAMK2D0.71474534
78BMPR20.71403373
79TLK10.70633723
80MAP3K140.70137348
81LYN0.69717133
82SCYL20.69155425
83MAP3K70.68690614
84CAMK2B0.68179803
85NLK0.67546719
86DMPK0.67494670
87STK100.66836110
88JAK10.66491457
89FYN0.65014103
90PDPK10.62970110
91DYRK20.61696816
92MAPKAPK20.61601269
93MAP3K50.60033618
94FGFR30.59418218
95MKNK10.59085385
96MAP3K10.57046474
97TAOK20.56368664
98CSNK1G30.53604734
99MST40.52556934
100GSK3A0.52069743
101PRKCZ0.51556802
102LRRK20.51367723
103PRKG10.51319220
104CDC42BPA0.51233439
105PRKCQ0.50814061
106STK380.50031151
107ACVR1B0.49221626
108RIPK40.48614216
109EPHA30.48441352
110WNK10.47599427
111DYRK1B0.47482332
112FGFR40.47115219
113GRK70.46767777
114MAP3K130.46147280
115TGFBR20.45832723
116PRKCH0.45823538
117CSNK1G10.45300916
118CSNK1A1L0.45154791
119BCKDK0.45144845
120SGK30.45041647
121CDK30.44438732
122PRKD20.43742728
123RAF10.43406127
124MAPK70.42963905
125IKBKB0.41984175
126KSR10.41817007
127PIM10.41370895
128MAPK120.40792733
129SGK20.40576703
130PRKCE0.40308357
131RET0.39209352
132ADRBK20.38523371
133MARK20.38320092
134PRKG20.38202716
135ADRBK10.38013256
136RPS6KA60.35985235
137CSF1R0.35915215
138PRKCD0.33612743
139TESK20.33274854
140IKBKE0.32931239
141CDK90.32581053
142RPS6KA20.31998965
143BCR0.31875764
144PRKD10.31748548
145PIM20.31692711
146MKNK20.31597019
147PRKAA20.30689113
148JAK20.30488516
149HCK0.30013745
150TBK10.29641863
151BRD40.27963380
152MAP3K20.27852596

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.26184772
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.36568741
3Staphylococcus aureus infection_Homo sapiens_hsa051503.03689897
4Sulfur metabolism_Homo sapiens_hsa009202.62026945
5Graft-versus-host disease_Homo sapiens_hsa053322.55860429
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54185130
7Fatty acid elongation_Homo sapiens_hsa000622.51993152
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.28911211
9Tuberculosis_Homo sapiens_hsa051522.26419748
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.23440629
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12093212
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08260803
13Measles_Homo sapiens_hsa051622.02697094
14Other glycan degradation_Homo sapiens_hsa005111.82581579
15Folate biosynthesis_Homo sapiens_hsa007901.71598600
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67864351
17African trypanosomiasis_Homo sapiens_hsa051431.63953325
18Influenza A_Homo sapiens_hsa051641.61459134
19Ether lipid metabolism_Homo sapiens_hsa005651.59657014
20Sphingolipid metabolism_Homo sapiens_hsa006001.57097366
21N-Glycan biosynthesis_Homo sapiens_hsa005101.54443702
22T cell receptor signaling pathway_Homo sapiens_hsa046601.54139232
23Acute myeloid leukemia_Homo sapiens_hsa052211.47731337
24Herpes simplex infection_Homo sapiens_hsa051681.45524919
25Lysosome_Homo sapiens_hsa041421.43921481
26Toxoplasmosis_Homo sapiens_hsa051451.43431441
27Viral myocarditis_Homo sapiens_hsa054161.40970417
28Asthma_Homo sapiens_hsa053101.39953653
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34643014
30TNF signaling pathway_Homo sapiens_hsa046681.33694879
31ABC transporters_Homo sapiens_hsa020101.28407458
32Type I diabetes mellitus_Homo sapiens_hsa049401.25495606
33Regulation of autophagy_Homo sapiens_hsa041401.22674302
34Hepatitis C_Homo sapiens_hsa051601.22288747
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19022626
36Linoleic acid metabolism_Homo sapiens_hsa005911.17559057
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.17007622
38Insulin secretion_Homo sapiens_hsa049111.15813753
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13795514
40Autoimmune thyroid disease_Homo sapiens_hsa053201.12099754
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11510313
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09965919
43Primary immunodeficiency_Homo sapiens_hsa053401.09863061
44Vibrio cholerae infection_Homo sapiens_hsa051101.09018390
45Histidine metabolism_Homo sapiens_hsa003401.08546467
46Steroid biosynthesis_Homo sapiens_hsa001001.07530311
47Hepatitis B_Homo sapiens_hsa051611.06704618
48Homologous recombination_Homo sapiens_hsa034401.04769862
49Circadian rhythm_Homo sapiens_hsa047101.04630446
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03334788
51Hematopoietic cell lineage_Homo sapiens_hsa046401.02701635
52Antigen processing and presentation_Homo sapiens_hsa046121.02639763
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.02585263
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98151588
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97422652
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93364790
57Non-small cell lung cancer_Homo sapiens_hsa052230.92205506
58Ribosome_Homo sapiens_hsa030100.91424769
59Arachidonic acid metabolism_Homo sapiens_hsa005900.91258765
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89986590
61Salmonella infection_Homo sapiens_hsa051320.89579308
62DNA replication_Homo sapiens_hsa030300.89055616
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88420020
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86979157
65Prolactin signaling pathway_Homo sapiens_hsa049170.86408664
66Non-homologous end-joining_Homo sapiens_hsa034500.85421940
67Mismatch repair_Homo sapiens_hsa034300.85381517
68Selenocompound metabolism_Homo sapiens_hsa004500.83634346
69Shigellosis_Homo sapiens_hsa051310.83198643
70Oxidative phosphorylation_Homo sapiens_hsa001900.82757311
71Cocaine addiction_Homo sapiens_hsa050300.81022974
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80493168
73Leishmaniasis_Homo sapiens_hsa051400.78902097
74Apoptosis_Homo sapiens_hsa042100.78869770
75VEGF signaling pathway_Homo sapiens_hsa043700.77935258
76Dorso-ventral axis formation_Homo sapiens_hsa043200.74049079
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71195591
78Endocytosis_Homo sapiens_hsa041440.70194060
79Pancreatic cancer_Homo sapiens_hsa052120.69801093
80B cell receptor signaling pathway_Homo sapiens_hsa046620.68607476
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68385821
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67141651
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66961796
84FoxO signaling pathway_Homo sapiens_hsa040680.65687198
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.65588210
86Alzheimers disease_Homo sapiens_hsa050100.65451898
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.64778119
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61843893
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61250474
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.60579907
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.59521257
92Parkinsons disease_Homo sapiens_hsa050120.59406577
93Epstein-Barr virus infection_Homo sapiens_hsa051690.58395720
94Vitamin B6 metabolism_Homo sapiens_hsa007500.58200722
95Type II diabetes mellitus_Homo sapiens_hsa049300.57508939
96Allograft rejection_Homo sapiens_hsa053300.57386352
97Pertussis_Homo sapiens_hsa051330.55336542
98Notch signaling pathway_Homo sapiens_hsa043300.55074366
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54619676
100Chronic myeloid leukemia_Homo sapiens_hsa052200.54522301
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53333900
102Osteoclast differentiation_Homo sapiens_hsa043800.53242031
103Viral carcinogenesis_Homo sapiens_hsa052030.53117405
104Renal cell carcinoma_Homo sapiens_hsa052110.51598245
105Serotonergic synapse_Homo sapiens_hsa047260.50858690
106MAPK signaling pathway_Homo sapiens_hsa040100.49300454
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47857757
108Pancreatic secretion_Homo sapiens_hsa049720.46875047
109Insulin resistance_Homo sapiens_hsa049310.46803885
110Choline metabolism in cancer_Homo sapiens_hsa052310.46430515
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.46196889
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45768059
113Peroxisome_Homo sapiens_hsa041460.44868132
114Nucleotide excision repair_Homo sapiens_hsa034200.44542795
115Rap1 signaling pathway_Homo sapiens_hsa040150.44508403
116Phagosome_Homo sapiens_hsa041450.44165847
117GnRH signaling pathway_Homo sapiens_hsa049120.43536649
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42333763
119Amoebiasis_Homo sapiens_hsa051460.39821967
120Chemokine signaling pathway_Homo sapiens_hsa040620.39437899
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39222833
122RNA polymerase_Homo sapiens_hsa030200.39170908
123Collecting duct acid secretion_Homo sapiens_hsa049660.39102143
124Endometrial cancer_Homo sapiens_hsa052130.38731249
125Pyrimidine metabolism_Homo sapiens_hsa002400.38580838
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38177766
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37943738
128Base excision repair_Homo sapiens_hsa034100.37092355
129Taste transduction_Homo sapiens_hsa047420.36599506
130HTLV-I infection_Homo sapiens_hsa051660.35894644
131Legionellosis_Homo sapiens_hsa051340.35326478
132Metabolic pathways_Homo sapiens_hsa011000.35193148
133Alcoholism_Homo sapiens_hsa050340.33204839
134Ovarian steroidogenesis_Homo sapiens_hsa049130.32732444
135Thyroid hormone synthesis_Homo sapiens_hsa049180.32369365
136HIF-1 signaling pathway_Homo sapiens_hsa040660.32311157
137mTOR signaling pathway_Homo sapiens_hsa041500.31821900
138Renin-angiotensin system_Homo sapiens_hsa046140.31298644
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.30430531
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.30153341
141Glycerolipid metabolism_Homo sapiens_hsa005610.29997899
142RNA degradation_Homo sapiens_hsa030180.29854634
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.29773635
144Inositol phosphate metabolism_Homo sapiens_hsa005620.29161850
145Platelet activation_Homo sapiens_hsa046110.28944913
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27538584
147Rheumatoid arthritis_Homo sapiens_hsa053230.26834871
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26801263
149Basal transcription factors_Homo sapiens_hsa030220.26682033
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26033767
151Colorectal cancer_Homo sapiens_hsa052100.24825321
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24187536
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24078340
154Malaria_Homo sapiens_hsa051440.23290489
155Purine metabolism_Homo sapiens_hsa002300.21996136
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21788559

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