FEZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.61772772
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.37979171
3sarcomere organization (GO:0045214)4.28777644
4muscle filament sliding (GO:0030049)3.80658353
5actin-myosin filament sliding (GO:0033275)3.80658353
6tricarboxylic acid cycle (GO:0006099)3.67534153
7regulation of skeletal muscle contraction (GO:0014819)3.58471524
8negative regulation of protein localization to cell surface (GO:2000009)3.56218433
9cell adhesion mediated by integrin (GO:0033627)3.56095872
10regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.54961606
11fatty acid transmembrane transport (GO:1902001)3.47253715
12carnitine shuttle (GO:0006853)3.39169636
13lysine catabolic process (GO:0006554)3.33845399
14lysine metabolic process (GO:0006553)3.33845399
15cardiac myofibril assembly (GO:0055003)3.33807619
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28789124
17vascular endothelial growth factor signaling pathway (GO:0038084)3.27412432
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26222231
19low-density lipoprotein particle clearance (GO:0034383)3.25902125
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.20672427
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.20570890
22negative regulation of fibrinolysis (GO:0051918)3.18876249
23relaxation of smooth muscle (GO:0044557)3.18142193
24actin-mediated cell contraction (GO:0070252)3.17606449
25apoptotic cell clearance (GO:0043277)3.15288427
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.09164440
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.07498012
28heart trabecula formation (GO:0060347)3.06586849
29regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.06541306
30myofibril assembly (GO:0030239)3.06538447
312-oxoglutarate metabolic process (GO:0006103)3.05967867
32regulation of tight junction assembly (GO:2000810)3.02849811
33regulation of fatty acid oxidation (GO:0046320)2.97648980
34basement membrane organization (GO:0071711)2.95172274
35cellular ketone body metabolic process (GO:0046950)2.94365660
36actomyosin structure organization (GO:0031032)2.93440395
37regulation of sequestering of triglyceride (GO:0010889)2.88068109
38stress fiber assembly (GO:0043149)2.87614086
39NADH metabolic process (GO:0006734)2.83447837
40chondrocyte proliferation (GO:0035988)2.83247093
41fatty acid beta-oxidation (GO:0006635)2.80484673
42regulation of coenzyme metabolic process (GO:0051196)2.79971704
43regulation of cofactor metabolic process (GO:0051193)2.79971704
44negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79008557
45endocardial cushion development (GO:0003197)2.78673463
46aspartate family amino acid catabolic process (GO:0009068)2.76125156
47regulation of acyl-CoA biosynthetic process (GO:0050812)2.74744239
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.71279754
49endothelial cell morphogenesis (GO:0001886)2.68856094
50cell migration involved in heart development (GO:0060973)2.67940992
51synaptic vesicle docking involved in exocytosis (GO:0016081)2.67359636
52L-phenylalanine metabolic process (GO:0006558)2.65951693
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65951693
54epoxygenase P450 pathway (GO:0019373)2.65717837
55paraxial mesoderm development (GO:0048339)2.61901983
56positive regulation of fatty acid oxidation (GO:0046321)2.61687832
57L-amino acid import (GO:0043092)2.59327382
58protein targeting to plasma membrane (GO:0072661)2.57692205
59positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57441091
60regulation of plasminogen activation (GO:0010755)2.56151970
61triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55819437
62epithelial cell-cell adhesion (GO:0090136)2.55129848
63cellular response to interferon-alpha (GO:0035457)2.55059588
64neuronal action potential propagation (GO:0019227)2.54241519
65tricarboxylic acid metabolic process (GO:0072350)2.53524449
66oxaloacetate metabolic process (GO:0006107)2.53398505
67plasma lipoprotein particle clearance (GO:0034381)2.53379769
68cardiac muscle cell development (GO:0055013)2.52913109
69positive regulation of fatty acid beta-oxidation (GO:0032000)2.52649134
70lymphangiogenesis (GO:0001946)2.52547837
71alpha-linolenic acid metabolic process (GO:0036109)2.52095468
72retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51523914
73cardiac muscle contraction (GO:0060048)2.50336980
74negative regulation of potassium ion transmembrane transport (GO:1901380)2.49683275
75actin filament-based movement (GO:0030048)2.49202687
76ketone body metabolic process (GO:1902224)2.48435168
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48397375
78sarcoplasmic reticulum calcium ion transport (GO:0070296)2.48383089
79protein localization to endosome (GO:0036010)2.48312199
80regulation of fatty acid beta-oxidation (GO:0031998)2.46681594
81fatty acid catabolic process (GO:0009062)2.46655172
82fatty acid oxidation (GO:0019395)2.46543119
83virion attachment to host cell (GO:0019062)2.46038834
84adhesion of symbiont to host cell (GO:0044650)2.46038834
85substrate-dependent cell migration (GO:0006929)2.45720131
86kidney mesenchyme development (GO:0072074)2.45549189
87retinal cone cell development (GO:0046549)2.45481280
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45246122
89regulation of integrin-mediated signaling pathway (GO:2001044)2.44137324
90substrate adhesion-dependent cell spreading (GO:0034446)2.44112315
91skeletal muscle fiber development (GO:0048741)2.43999170
92regulation of cell communication by electrical coupling (GO:0010649)2.43497104
93lipid oxidation (GO:0034440)2.43337101
94positive regulation of catecholamine secretion (GO:0033605)2.43185976
95regulation of clathrin-mediated endocytosis (GO:2000369)2.42791003
96regulation of female gonad development (GO:2000194)2.42588131
97regulation of fibrinolysis (GO:0051917)2.42421949
98platelet degranulation (GO:0002576)2.41653227
99carnitine transmembrane transport (GO:1902603)2.41438710
100cartilage morphogenesis (GO:0060536)2.41267762
101anterior/posterior axis specification, embryo (GO:0008595)2.41254020
102cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41136777
103glyoxylate metabolic process (GO:0046487)2.40563643
104axon extension involved in axon guidance (GO:0048846)2.40028306
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.40028306
106regulation of cardiac muscle hypertrophy (GO:0010611)2.38666046
107positive regulation of muscle hypertrophy (GO:0014742)2.38091038
108positive regulation of cardiac muscle hypertrophy (GO:0010613)2.38091038
109pericardium development (GO:0060039)2.37258787
110glutamate secretion (GO:0014047)2.37154708
111central nervous system myelination (GO:0022010)2.37113955
112axon ensheathment in central nervous system (GO:0032291)2.37113955
113wound healing, spreading of epidermal cells (GO:0035313)2.37108449
114regulation of actin filament-based movement (GO:1903115)2.36578542
115endocytic recycling (GO:0032456)2.36568158
116acetyl-CoA metabolic process (GO:0006084)2.36445268
117positive regulation of male gonad development (GO:2000020)2.36418513
118cell migration involved in sprouting angiogenesis (GO:0002042)2.35986087
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.35463093
120protein carboxylation (GO:0018214)2.35192722
121peptidyl-glutamic acid carboxylation (GO:0017187)2.35192722
122axon extension (GO:0048675)2.35144586
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34583564
124regulation of muscle hypertrophy (GO:0014743)2.34267434
125cardiac cell development (GO:0055006)2.33764475
126protein hydroxylation (GO:0018126)2.33432206
127creatine metabolic process (GO:0006600)2.33250761
128myotube cell development (GO:0014904)2.33237861
129regulation of cholesterol storage (GO:0010885)2.33062619
130membrane raft organization (GO:0031579)2.32920359
131regulation of macrophage chemotaxis (GO:0010758)2.32738469
132cardiac muscle tissue morphogenesis (GO:0055008)2.32241518
133amino-acid betaine transport (GO:0015838)2.32218094
134carnitine transport (GO:0015879)2.32218094
135positive regulation of blood coagulation (GO:0030194)2.32029337
136positive regulation of hemostasis (GO:1900048)2.32029337
137metanephric mesenchyme development (GO:0072075)2.31844805
138peptidyl-proline hydroxylation (GO:0019511)2.31825145
139negative regulation of cell size (GO:0045792)2.31600475
140negative regulation of vascular permeability (GO:0043116)2.30935515
141relaxation of muscle (GO:0090075)2.29468668
142response to muscle activity (GO:0014850)2.29068837
143regulation of dendritic spine development (GO:0060998)2.28744836
144muscle cell fate commitment (GO:0042693)2.28714108
145neuron projection extension (GO:1990138)2.26618596
146amino acid import (GO:0043090)2.25872982
147sodium ion export (GO:0071436)2.25773061
148ventricular septum development (GO:0003281)2.25178058
149smooth muscle tissue development (GO:0048745)2.24676207
150hippo signaling (GO:0035329)2.24547956
151cellular potassium ion homeostasis (GO:0030007)2.24266658
152collagen fibril organization (GO:0030199)2.24075805
153regulation of short-term neuronal synaptic plasticity (GO:0048172)2.23200532
154muscle cell cellular homeostasis (GO:0046716)2.23158039
155regulation of DNA methylation (GO:0044030)2.21245268
156regulation of relaxation of muscle (GO:1901077)2.21192968
157tooth mineralization (GO:0034505)2.20508400
158postsynaptic membrane organization (GO:0001941)2.18630180
159regulation of cardiac muscle cell differentiation (GO:2000725)2.18328401
160regulation of phospholipid biosynthetic process (GO:0071071)2.13527883
161clathrin coat assembly (GO:0048268)2.12889629
162interkinetic nuclear migration (GO:0022027)2.12242267
163regulation of muscle adaptation (GO:0043502)2.11048277
164membrane assembly (GO:0071709)2.10533855
165urinary tract smooth muscle contraction (GO:0014848)2.09761167
166muscle contraction (GO:0006936)2.08438991
167skin morphogenesis (GO:0043589)2.07612705
168positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.07506003
169regulation of the force of heart contraction (GO:0002026)2.07312697
170negative regulation of cardiac muscle hypertrophy (GO:0010614)2.06914582
171relaxation of cardiac muscle (GO:0055119)2.06881905
172negative regulation of leukocyte chemotaxis (GO:0002689)2.06504219
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.06201395
174positive regulation of dendritic spine development (GO:0060999)2.05768620
175neuron remodeling (GO:0016322)2.05154781
176response to magnesium ion (GO:0032026)2.04236010
177negative regulation of homotypic cell-cell adhesion (GO:0034111)2.02920455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.74306586
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.83782650
3EZH2_22144423_ChIP-Seq_EOC_Human4.83569382
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.37689408
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.82387286
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.38524184
7CLOCK_20551151_ChIP-Seq_293T_Human3.34818538
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.21567489
9GBX2_23144817_ChIP-Seq_PC3_Human3.09261802
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94457151
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72735615
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60495410
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.59512273
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32893570
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.24592607
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.20824595
17ZNF263_19887448_ChIP-Seq_K562_Human2.20713833
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14764720
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12444878
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.02309197
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.99048012
22* EP300_21415370_ChIP-Seq_HL-1_Mouse1.97508856
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97503359
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96095394
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92758279
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90398584
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89561556
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.88811198
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87743110
30TP53_16413492_ChIP-PET_HCT116_Human1.86987869
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85539015
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83786840
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82029593
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.79772940
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78592344
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76600046
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75112873
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72464327
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72038336
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71354817
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.70663565
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.69708194
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.69708194
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69558223
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.69307413
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66642528
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.64704004
48SMAD4_21799915_ChIP-Seq_A2780_Human1.62937512
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.62924858
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61497881
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61497881
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61168133
53CJUN_26792858_Chip-Seq_BT549_Human1.59869159
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.59695161
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57376953
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57023118
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53304533
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53271445
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49430620
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48211996
61AHR_22903824_ChIP-Seq_MCF-7_Human1.48204260
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47761285
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47572341
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47217588
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47145313
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46538140
67TP53_18474530_ChIP-ChIP_U2OS_Human1.46492839
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45351359
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45351359
70P300_19829295_ChIP-Seq_ESCs_Human1.44452488
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.44137146
72ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42598408
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.40869461
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39351892
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39009325
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.38553763
77LXR_22292898_ChIP-Seq_THP-1_Human1.37341166
78ATF3_27146783_Chip-Seq_COLON_Human1.36801009
79* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36540709
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.36460878
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36390344
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35975595
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35812728
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35258575
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.34995094
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34330150
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32971427
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30857475
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29210161
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28383591
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.28069552
92* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27842710
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27412475
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27214499
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26686804
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26400318
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.26340309
98* SOX2_20726797_ChIP-Seq_SW620_Human1.25817325
99* STAT3_23295773_ChIP-Seq_U87_Human1.25569208
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25242801
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24832010
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24717103
103AR_21572438_ChIP-Seq_LNCaP_Human1.23969297
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21902323
105RACK7_27058665_Chip-Seq_MCF-7_Human1.21704352
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20131493
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19765337
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19360267
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18662184
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.17763231
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17312394
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17256629
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17179194
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17013597
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.16354522
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15704299
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15033243
118AR_25329375_ChIP-Seq_VCAP_Human1.14961039
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14454072
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.14054582
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13527892
122TAF15_26573619_Chip-Seq_HEK293_Human1.13092351
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.12844656
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12514831
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.11809173
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10966262
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10966262
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10898568
129TCF4_23295773_ChIP-Seq_U87_Human1.10229168
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.08886904
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07644003
132* KDM2B_26808549_Chip-Seq_REH_Human1.06651025
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05800442
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05154758
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05020969
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04174282
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04046313
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03541349
139* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02259947
140SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01527311
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01313420
142* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00957917
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00890562
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00890562
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99958058
146FUS_26573619_Chip-Seq_HEK293_Human0.99606993
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.99500772
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.99452731
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99252008
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98641804
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98382875
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98283513
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97833418
154EGR1_19032775_ChIP-ChIP_M12_Human0.97678417
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.97667441
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96812563
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.96703787
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96069004
159HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95573285
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94490846
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94445840
162KDM2B_26808549_Chip-Seq_DND41_Human0.94151473
163GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93058036
164NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92770715
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91322075
166TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90945340
167HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90385609
168* BRD4_25478319_ChIP-Seq_HGPS_Human0.89804803
169FOXA2_19822575_ChIP-Seq_HepG2_Human0.88165691
170TP53_22127205_ChIP-Seq_IMR90_Human0.87551091
171SPI1_20517297_ChIP-Seq_HL60_Human0.87207845
172GATA1_19941826_ChIP-Seq_K562_Human0.87156259
173ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86607616
174ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85194704
175CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84617156
176SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83281088
177KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82210382
178P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81569628
179* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81405797
180CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80499582
181MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79132836
182SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78909857
183* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78331007
184POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77613704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.39802032
2MP0004084_abnormal_cardiac_muscle3.20344329
3MP0003705_abnormal_hypodermis_morpholog3.06245718
4MP0000751_myopathy2.96214545
5MP0002837_dystrophic_cardiac_calcinosis2.86430770
6MP0000749_muscle_degeneration2.78917975
7MP0003279_aneurysm2.72238497
8MP0004130_abnormal_muscle_cell2.67435337
9MP0010368_abnormal_lymphatic_system2.65355087
10MP0005360_urolithiasis2.47741624
11MP0005330_cardiomyopathy2.43897725
12MP0004036_abnormal_muscle_relaxation2.42712679
13MP0000569_abnormal_digit_pigmentation2.42249273
14MP0009840_abnormal_foam_cell2.36293400
15MP0009780_abnormal_chondrocyte_physiolo2.21659852
16MP0003646_muscle_fatigue2.21433427
17MP0004087_abnormal_muscle_fiber2.11044171
18MP0000747_muscle_weakness2.06374239
19MP0000750_abnormal_muscle_regeneration2.02961173
20MP0004215_abnormal_myocardial_fiber2.01348424
21MP0002972_abnormal_cardiac_muscle1.91735149
22MP0005620_abnormal_muscle_contractility1.91288588
23MP0003806_abnormal_nucleotide_metabolis1.91067751
24MP0002269_muscular_atrophy1.87897513
25MP0004272_abnormal_basement_membrane1.87632633
26MP0008775_abnormal_heart_ventricle1.85903957
27MP0003566_abnormal_cell_adhesion1.85336426
28MP0005623_abnormal_meninges_morphology1.84868029
29MP0000013_abnormal_adipose_tissue1.82780121
30MP0005257_abnormal_intraocular_pressure1.81844009
31MP0010030_abnormal_orbit_morphology1.80816800
32MP0001299_abnormal_eye_distance/1.79190847
33MP0004270_analgesia1.78239764
34MP0005058_abnormal_lysosome_morphology1.77727704
35MP0002139_abnormal_hepatobiliary_system1.77463211
36MP0005385_cardiovascular_system_phenoty1.76321552
37MP0001544_abnormal_cardiovascular_syste1.76321552
38MP0006138_congestive_heart_failure1.74846286
39MP0000343_altered_response_to1.69559287
40MP0005085_abnormal_gallbladder_physiolo1.62895929
41MP0005275_abnormal_skin_tensile1.60474318
42MP0010630_abnormal_cardiac_muscle1.57632945
43MP0004484_altered_response_of1.56932328
44MP0003879_abnormal_hair_cell1.56531416
45MP0001879_abnormal_lymphatic_vessel1.53413435
46MP0002332_abnormal_exercise_endurance1.52650928
47MP0003828_pulmonary_edema1.51619649
48MP0003191_abnormal_cellular_cholesterol1.50818105
49MP0009250_abnormal_appendicular_skeleto1.49560765
50MP0005670_abnormal_white_adipose1.48333654
51MP0000759_abnormal_skeletal_muscle1.46618694
52MP0009384_cardiac_valve_regurgitation1.45394501
53MP0003091_abnormal_cell_migration1.42974754
54MP0002106_abnormal_muscle_physiology1.42906975
55MP0004145_abnormal_muscle_electrophysio1.37889739
56MP0003941_abnormal_skin_development1.37791852
57MP0005023_abnormal_wound_healing1.37524811
58MP0001958_emphysema1.36377134
59MP0005083_abnormal_biliary_tract1.35617054
60MP0003718_maternal_effect1.33618422
61MP0002108_abnormal_muscle_morphology1.33394622
62MP0005165_increased_susceptibility_to1.32789249
63MP0004233_abnormal_muscle_weight1.32068710
64MP0000778_abnormal_nervous_system1.31189955
65MP0003221_abnormal_cardiomyocyte_apopto1.30470471
66MP0003252_abnormal_bile_duct1.29164932
67MP0005365_abnormal_bile_salt1.28348212
68MP0005332_abnormal_amino_acid1.25126751
69MP0005666_abnormal_adipose_tissue1.23041151
70MP0010329_abnormal_lipoprotein_level1.22266266
71MP0003880_abnormal_central_pattern1.21289322
72MP0005369_muscle_phenotype1.21082002
73MP0004859_abnormal_synaptic_plasticity1.19672604
74MP0002295_abnormal_pulmonary_circulatio1.18636342
75MP0005167_abnormal_blood-brain_barrier1.18415796
76MP0004510_myositis1.16054112
77MP0000767_abnormal_smooth_muscle1.15949961
78MP0002896_abnormal_bone_mineralization1.15919629
79MP0004185_abnormal_adipocyte_glucose1.14560025
80MP0003635_abnormal_synaptic_transmissio1.13576581
81MP0005187_abnormal_penis_morphology1.13208682
82MP0003950_abnormal_plasma_membrane1.12869890
83MP0003137_abnormal_impulse_conducting1.11416580
84MP0002272_abnormal_nervous_system1.10605179
85MP0000762_abnormal_tongue_morphology1.09946884
86MP0004885_abnormal_endolymph1.09662177
87MP0001486_abnormal_startle_reflex1.08863280
88MP0005595_abnormal_vascular_smooth1.08274038
89MP0005503_abnormal_tendon_morphology1.06316389
90MP0000534_abnormal_ureter_morphology1.06082186
91MP0008875_abnormal_xenobiotic_pharmacok1.03725632
92MP0004085_abnormal_heartbeat1.02998293
93MP0005319_abnormal_enzyme/_coenzyme1.02563028
94MP0002128_abnormal_blood_circulation1.02156483
95MP0006292_abnormal_olfactory_placode1.01170243
96MP0000604_amyloidosis1.01094955
97MP0005375_adipose_tissue_phenotype1.01047945
98MP0000249_abnormal_blood_vessel1.00702046
99MP0003329_amyloid_beta_deposits0.99649362
100MP0000230_abnormal_systemic_arterial0.99032690
101MP0003075_altered_response_to0.97770656
102MP0005584_abnormal_enzyme/coenzyme_acti0.96445778
103MP0002971_abnormal_brown_adipose0.96387507
104MP0006036_abnormal_mitochondrial_physio0.95166943
105MP0001542_abnormal_bone_strength0.94434586
106MP0003633_abnormal_nervous_system0.91920515
107MP0000733_abnormal_muscle_development0.91446008
108MP0005164_abnormal_response_to0.90864824
109MP0002118_abnormal_lipid_homeostasis0.90226048
110MP0003755_abnormal_palate_morphology0.90061353
111MP0006054_spinal_hemorrhage0.89849419
112MP0005197_abnormal_uvea_morphology0.89572861
113MP0003303_peritoneal_inflammation0.89333995
114MP0001501_abnormal_sleep_pattern0.88988573
115MP0000428_abnormal_craniofacial_morphol0.88563407
116MP0005423_abnormal_somatic_nervous0.86307347
117MP0002734_abnormal_mechanical_nocicepti0.86268987
118MP0003195_calcinosis0.85721548
119MP0002064_seizures0.85559213
120MP0003942_abnormal_urinary_system0.84519793
121MP0001984_abnormal_olfaction0.84429061
122MP0000003_abnormal_adipose_tissue0.84253681
123MP0005084_abnormal_gallbladder_morpholo0.83058041
124MP0002572_abnormal_emotion/affect_behav0.82142270
125MP0010352_gastrointestinal_tract_polyps0.81043153
126MP0002063_abnormal_learning/memory/cond0.79314376
127MP0000920_abnormal_myelination0.79212173
128MP0003724_increased_susceptibility_to0.79130616
129MP0000609_abnormal_liver_physiology0.77136465
130MP0004142_abnormal_muscle_tone0.77088433
131MP0003385_abnormal_body_wall0.75702920
132MP0001533_abnormal_skeleton_physiology0.75429588
133MP0001614_abnormal_blood_vessel0.74827252
134MP0004883_abnormal_blood_vessel0.74807862
135MP0009643_abnormal_urine_homeostasis0.74382703
136MP0008004_abnormal_stomach_pH0.74147023
137MP0003634_abnormal_glial_cell0.73886768
138MP0001440_abnormal_grooming_behavior0.73833027
139MP0003631_nervous_system_phenotype0.73662196
140MP0000266_abnormal_heart_morphology0.73440190
141MP0001756_abnormal_urination0.73352638
142MP0003690_abnormal_glial_cell0.73160520
143MP0003045_fibrosis0.72595449
144MP0005551_abnormal_eye_electrophysiolog0.72502090
145MP0005508_abnormal_skeleton_morphology0.72109817
146MP0003935_abnormal_craniofacial_develop0.71029771
147MP0002234_abnormal_pharynx_morphology0.70807063
148MP0001293_anophthalmia0.69563980
149MP0009046_muscle_twitch0.69113372
150MP0010386_abnormal_urinary_bladder0.68770845

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.20863246
2Protrusio acetabuli (HP:0003179)3.96240506
3Exercise-induced muscle cramps (HP:0003710)3.94577451
4Increased connective tissue (HP:0009025)3.82760420
5Hyporeflexia of lower limbs (HP:0002600)3.79374654
6Premature rupture of membranes (HP:0001788)3.63563846
7Cerebral aneurysm (HP:0004944)3.49932918
8Exercise-induced myalgia (HP:0003738)3.47118910
9Sudden death (HP:0001699)3.45196079
10Myoglobinuria (HP:0002913)3.31850546
11Asymmetric septal hypertrophy (HP:0001670)3.23047387
12Ventricular tachycardia (HP:0004756)3.18155259
13EMG: myopathic abnormalities (HP:0003458)3.17052225
14Difficulty climbing stairs (HP:0003551)3.12991052
15Difficulty running (HP:0009046)2.97850048
16Myotonia (HP:0002486)2.93971800
17Right ventricular cardiomyopathy (HP:0011663)2.89279725
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.87945416
19Aortic aneurysm (HP:0004942)2.85513380
20Muscle fiber inclusion bodies (HP:0100299)2.85339324
21Systemic lupus erythematosus (HP:0002725)2.82108183
22Axonal loss (HP:0003447)2.82062947
23Overgrowth (HP:0001548)2.81751125
24Lipoatrophy (HP:0100578)2.80113207
25Type 1 muscle fiber predominance (HP:0003803)2.76225958
26Abnormality of the calf musculature (HP:0001430)2.74184289
27Neurofibrillary tangles (HP:0002185)2.74155980
28Calf muscle hypertrophy (HP:0008981)2.73102732
29Xanthomatosis (HP:0000991)2.72323008
30Muscle stiffness (HP:0003552)2.68693156
31Hypoalphalipoproteinemia (HP:0003233)2.68490079
32Atrial fibrillation (HP:0005110)2.67183844
33Aortic dissection (HP:0002647)2.64954139
34Rhabdomyolysis (HP:0003201)2.62831854
35Aplasia of the musculature (HP:0100854)2.62208046
36Hip contracture (HP:0003273)2.61532617
37Deep venous thrombosis (HP:0002625)2.61445311
38Limited hip movement (HP:0008800)2.60121579
39Muscle hypertrophy of the lower extremities (HP:0008968)2.59690347
40Complement deficiency (HP:0004431)2.56531170
41Distal lower limb muscle weakness (HP:0009053)2.54720586
42Increased variability in muscle fiber diameter (HP:0003557)2.51583170
43Nemaline bodies (HP:0003798)2.49919241
44Primary atrial arrhythmia (HP:0001692)2.47144195
45Spinal rigidity (HP:0003306)2.43555516
46Distal arthrogryposis (HP:0005684)2.42256360
47Broad metatarsal (HP:0001783)2.41434491
48Supernumerary spleens (HP:0009799)2.41327418
49Supraventricular arrhythmia (HP:0005115)2.41240115
50Abnormality of skeletal muscle fiber size (HP:0012084)2.39558416
51Abnormality of fatty-acid metabolism (HP:0004359)2.35998847
52Supraventricular tachycardia (HP:0004755)2.34359301
53Ulnar deviation of the wrist (HP:0003049)2.34077652
54Palpitations (HP:0001962)2.33211144
55Dilated cardiomyopathy (HP:0001644)2.25029172
56Round ear (HP:0100830)2.24086912
57Febrile seizures (HP:0002373)2.20548670
58Peritonitis (HP:0002586)2.20503452
59Scapular winging (HP:0003691)2.19013584
60Atonic seizures (HP:0010819)2.18538873
61Facial diplegia (HP:0001349)2.18300117
62Polycythemia (HP:0001901)2.18156192
63Limb-girdle muscle atrophy (HP:0003797)2.17590188
64Vertebral compression fractures (HP:0002953)2.17429255
65Ankle contracture (HP:0006466)2.17055335
66Mildly elevated creatine phosphokinase (HP:0008180)2.16712552
67Action tremor (HP:0002345)2.14707558
68Slender build (HP:0001533)2.13229346
69Abnormality of the Achilles tendon (HP:0005109)2.13166335
70Hypoglycemic coma (HP:0001325)2.12430193
71Bundle branch block (HP:0011710)2.10851230
72Hyperammonemia (HP:0001987)2.10307149
73Coronal craniosynostosis (HP:0004440)2.09245503
74Achilles tendon contracture (HP:0001771)2.07474685
75Dilatation of the ascending aorta (HP:0005111)2.07448053
76Abnormality of complement system (HP:0005339)2.06302820
77Distal upper limb amyotrophy (HP:0007149)2.05576837
78Upper limb amyotrophy (HP:0009129)2.05576837
79Hypolipoproteinemia (HP:0010981)2.04728622
80Skin nodule (HP:0200036)2.04526104
81Aneurysm (HP:0002617)2.03365685
82Hyperlipoproteinemia (HP:0010980)2.01111293
83Spondylolisthesis (HP:0003302)2.00560626
84Absent phalangeal crease (HP:0006109)2.00001313
85Gowers sign (HP:0003391)1.99004396
86Myocardial infarction (HP:0001658)1.98050536
87Tarsal synostosis (HP:0008368)1.98018629
88Lymphangioma (HP:0100764)1.97718024
89Fragile skin (HP:0001030)1.97547585
90Neonatal short-limb short stature (HP:0008921)1.97116181
91Glomerulonephritis (HP:0000099)1.96921183
92Wormian bones (HP:0002645)1.94789328
93Short 1st metacarpal (HP:0010034)1.93774430
94Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93774430
95Synostosis involving bones of the feet (HP:0009140)1.93094067
96Synostosis involving bones of the lower limbs (HP:0009138)1.93094067
97Shallow orbits (HP:0000586)1.91908904
98Ventricular arrhythmia (HP:0004308)1.91357037
99Subaortic stenosis (HP:0001682)1.91252990
100Abnormality of the left ventricular outflow tract (HP:0011103)1.91252990
101Abnormal atrioventricular conduction (HP:0005150)1.91179022
102Nonimmune hydrops fetalis (HP:0001790)1.90850472
103Knee flexion contracture (HP:0006380)1.89879757
104Ketosis (HP:0001946)1.89425982
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88141579
106Wide anterior fontanel (HP:0000260)1.87781885
107Ketoacidosis (HP:0001993)1.87718248
108Foot dorsiflexor weakness (HP:0009027)1.87378976
109Vascular tortuosity (HP:0004948)1.86703869
110Mesangial abnormality (HP:0001966)1.85876811
111Cerebral hemorrhage (HP:0001342)1.84955479
112Areflexia of lower limbs (HP:0002522)1.83611561
113Rapidly progressive (HP:0003678)1.83347441
114Wrist flexion contracture (HP:0001239)1.82752783
115Syncope (HP:0001279)1.81807013
116Hypoplasia of the iris (HP:0007676)1.81592455
117Aortic valve stenosis (HP:0001650)1.80772330
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79857863
119Nephritis (HP:0000123)1.79352104
120Atrophic scars (HP:0001075)1.78399176
121Striae distensae (HP:0001065)1.77746571
122Frequent falls (HP:0002359)1.77370013
123Calcaneovalgus deformity (HP:0001848)1.77098079
124Abnormal cartilage morphology (HP:0002763)1.76495121
125Cervical subluxation (HP:0003308)1.76108219
126Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75468996
127Soft skin (HP:0000977)1.75334787
128Myopathic facies (HP:0002058)1.75005494
129Abnormality of the ischium (HP:0003174)1.74585139
130Neck muscle weakness (HP:0000467)1.74403599
131Cerebral inclusion bodies (HP:0100314)1.74376828
132Abnormality of carpal bone ossification (HP:0006257)1.74178598
133Muscular dystrophy (HP:0003560)1.73949201
134Atrioventricular block (HP:0001678)1.73798259
135Arterial tortuosity (HP:0005116)1.72280608
136Heart block (HP:0012722)1.71209295
137Abnormality of the foot musculature (HP:0001436)1.70943890
138Bladder diverticulum (HP:0000015)1.70087128
139Abnormal finger flexion creases (HP:0006143)1.66273889
140Abnormality of the shoulder girdle musculature (HP:0001435)1.65912755
141Dysmetric saccades (HP:0000641)1.65555849
142Deformed tarsal bones (HP:0008119)1.62949222
143Mitral regurgitation (HP:0001653)1.62839150
144Abnormality of the 1st metacarpal (HP:0010009)1.61879155
145Increased circulating renin level (HP:0000848)1.61554237
146Osteolytic defects of the hand bones (HP:0009699)1.59202945
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.59202945
148Conjunctival telangiectasia (HP:0000524)1.58634946
149Hydroxyprolinuria (HP:0003080)1.57175256
150Abnormality of proline metabolism (HP:0010907)1.57175256
151Limb-girdle muscle weakness (HP:0003325)1.56673044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.56434805
2TRIB33.48225211
3KDR3.18936377
4AKT33.10628692
5TIE13.04780718
6PKN22.96471523
7TGFBR22.67303250
8NTRK22.60181522
9MYLK2.47043462
10BCKDK2.36535645
11EPHA42.29668547
12LIMK12.24857955
13MAP3K132.11807906
14DMPK2.05101888
15LATS22.02961605
16PHKG21.97483030
17PHKG11.97483030
18ERN11.94589702
19TESK11.86470786
20PDK21.85070004
21TESK21.71055970
22OBSCN1.67461887
23NEK11.65701849
24MARK11.65455784
25NTRK31.63372946
26LMTK21.58694913
27LATS11.55888245
28NEK91.50637249
29PDK41.48988293
30PDK31.48988293
31ACVR1B1.48765935
32PIK3CA1.46539581
33PAK31.37862416
34SIK11.36864730
35PTK2B1.32622799
36MAP2K31.32188912
37RIPK11.30331401
38PDGFRA1.29681504
39MAP3K111.29435183
40NME21.28078477
41STK31.26830878
42EPHB21.23409492
43KSR21.22338216
44PNCK1.19468220
45TGFBR11.14589082
46DDR21.12529433
47PAK21.12380193
48CDK121.10490225
49MAPKAPK31.10306578
50SCYL21.10086408
51PINK11.09723916
52MAP2K11.09047383
53TNIK1.08746474
54MOS1.06317950
55PIK3CG1.03440758
56STK391.01640553
57ERBB41.01310126
58TBK10.99860641
59MAPK120.98368581
60ARAF0.95733232
61ILK0.95183195
62PRKD10.95026172
63TRPM70.93754852
64PIM20.93230162
65RET0.92990713
66PTK20.92494042
67CAMK2A0.92066278
68EPHA20.91350595
69FER0.90860426
70PAK40.90534986
71ERBB30.90352386
72MINK10.90141550
73KSR10.89856306
74LRRK20.88956450
75MAP3K90.87179776
76CASK0.83769330
77DAPK30.81960223
78CAMK2B0.81752292
79SGK20.79155334
80BMX0.78982522
81ROCK10.77172597
82PDGFRB0.76648071
83PLK20.76397221
84ABL20.76129972
85DAPK20.75325517
86MAP2K40.72267162
87BRD40.71215816
88MAP3K50.70430069
89GRK70.69854030
90MUSK0.69103157
91PRKG20.68996787
92BMPR1B0.68169520
93PKN10.67950425
94MAPK70.67369422
95PRKG10.67242609
96CDK190.67241597
97TYRO30.65944925
98PBK0.65880831
99STK38L0.65337912
100FGFR40.64981850
101SGK30.64963947
102CDK50.63683162
103MARK30.62622660
104PDPK10.61395960
105PAK60.61199750
106FRK0.60327386
107PTK60.60057234
108EPHB10.59366410
109CAMK1D0.57769830
110CAMKK10.57407290
111STK380.57141326
112NTRK10.56022701
113CDK90.56015887
114CAMKK20.55586952
115MAP3K70.55209593
116STK240.54207588
117MAP3K60.54128905
118CAMK10.54052233
119MAP3K30.53601100
120NEK60.52738616
121ADRBK10.51910027
122PRKCE0.48095058
123WNK10.47401926
124MELK0.47322114
125SGK2230.46746517
126SGK4940.46746517
127TAOK10.46521265
128CAMK2G0.43963966
129MAPK100.43214263
130TYK20.43005960
131STK100.42162121
132CAMK2D0.41766215
133PRKACB0.40937255
134FGFR10.40881690
135WNK40.40789763
136OXSR10.37849108
137PDK10.37698369
138MAPK130.36824237
139BRSK20.36587644
140JAK10.34820189
141ROCK20.34332407
142MET0.32695093
143PRKD30.32019856
144EGFR0.31682114
145MAP3K10.31276523
146BLK0.30794548
147SRC0.30770480
148MAPKAPK20.30231851
149SIK30.29642546
150CDK140.27216628
151CDC42BPA0.26810753
152RAF10.26216969
153MAPKAPK50.26171342
154MTOR0.25936253

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.50900213
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01630824
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.95677972
4Nitrogen metabolism_Homo sapiens_hsa009102.44468395
5Fatty acid degradation_Homo sapiens_hsa000712.42004057
6Propanoate metabolism_Homo sapiens_hsa006402.21761639
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11530001
8Dilated cardiomyopathy_Homo sapiens_hsa054142.06552351
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.06540008
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04526989
11Carbon metabolism_Homo sapiens_hsa012001.95604737
12Arginine biosynthesis_Homo sapiens_hsa002201.88812335
13PPAR signaling pathway_Homo sapiens_hsa033201.82955992
14Dorso-ventral axis formation_Homo sapiens_hsa043201.77800935
15Fatty acid metabolism_Homo sapiens_hsa012121.76452182
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.71326166
17Circadian rhythm_Homo sapiens_hsa047101.70291641
18Complement and coagulation cascades_Homo sapiens_hsa046101.69764944
19Circadian entrainment_Homo sapiens_hsa047131.64231074
20Morphine addiction_Homo sapiens_hsa050321.59615961
21GABAergic synapse_Homo sapiens_hsa047271.58525607
22Pyruvate metabolism_Homo sapiens_hsa006201.58069287
23Calcium signaling pathway_Homo sapiens_hsa040201.57971207
24Cardiac muscle contraction_Homo sapiens_hsa042601.57770104
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55481985
26Gastric acid secretion_Homo sapiens_hsa049711.54669442
27Renin secretion_Homo sapiens_hsa049241.54020584
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50940804
29Glutamatergic synapse_Homo sapiens_hsa047241.50693679
30Nicotine addiction_Homo sapiens_hsa050331.50254452
31Butanoate metabolism_Homo sapiens_hsa006501.49211785
32Synaptic vesicle cycle_Homo sapiens_hsa047211.48532196
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44090082
34Insulin secretion_Homo sapiens_hsa049111.44075254
35Staphylococcus aureus infection_Homo sapiens_hsa051501.43577927
36Salivary secretion_Homo sapiens_hsa049701.42155249
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41963889
38Long-term potentiation_Homo sapiens_hsa047201.36715916
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33504888
40Tryptophan metabolism_Homo sapiens_hsa003801.31357521
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30538769
42Hippo signaling pathway_Homo sapiens_hsa043901.28277212
43cAMP signaling pathway_Homo sapiens_hsa040241.27887260
44Starch and sucrose metabolism_Homo sapiens_hsa005001.26336830
45Focal adhesion_Homo sapiens_hsa045101.25153081
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24758632
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21909400
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20401624
49Amphetamine addiction_Homo sapiens_hsa050311.19927630
50Olfactory transduction_Homo sapiens_hsa047401.15902772
51Cocaine addiction_Homo sapiens_hsa050301.14641496
52Peroxisome_Homo sapiens_hsa041461.14588876
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10154962
54Dopaminergic synapse_Homo sapiens_hsa047281.10051318
55Biosynthesis of amino acids_Homo sapiens_hsa012301.09728431
56Taste transduction_Homo sapiens_hsa047421.09154302
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07907991
58Cholinergic synapse_Homo sapiens_hsa047251.07433869
59Ovarian steroidogenesis_Homo sapiens_hsa049131.07260395
60Sulfur metabolism_Homo sapiens_hsa009201.04630624
61Prion diseases_Homo sapiens_hsa050201.04177163
62Melanogenesis_Homo sapiens_hsa049161.03963268
63Parkinsons disease_Homo sapiens_hsa050121.03532829
64Axon guidance_Homo sapiens_hsa043601.00438557
65TGF-beta signaling pathway_Homo sapiens_hsa043500.99791881
66Bile secretion_Homo sapiens_hsa049760.99393166
67Mineral absorption_Homo sapiens_hsa049780.99067714
68Viral myocarditis_Homo sapiens_hsa054160.98008353
69ECM-receptor interaction_Homo sapiens_hsa045120.95540004
70Long-term depression_Homo sapiens_hsa047300.94631192
71GnRH signaling pathway_Homo sapiens_hsa049120.93997152
72Serotonergic synapse_Homo sapiens_hsa047260.89211789
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89000515
74Caffeine metabolism_Homo sapiens_hsa002320.88843537
75Amoebiasis_Homo sapiens_hsa051460.88495166
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88083135
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85408609
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.85357841
79Protein digestion and absorption_Homo sapiens_hsa049740.81310752
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.80655360
81Alzheimers disease_Homo sapiens_hsa050100.79383472
82Collecting duct acid secretion_Homo sapiens_hsa049660.78845913
83Proteoglycans in cancer_Homo sapiens_hsa052050.78135915
84Lysosome_Homo sapiens_hsa041420.77128668
85Oxidative phosphorylation_Homo sapiens_hsa001900.76839478
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75874000
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75812386
88Pancreatic secretion_Homo sapiens_hsa049720.75552534
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74328968
90Ras signaling pathway_Homo sapiens_hsa040140.74124159
91Galactose metabolism_Homo sapiens_hsa000520.73162481
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72296036
93Shigellosis_Homo sapiens_hsa051310.72081666
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71935688
95Estrogen signaling pathway_Homo sapiens_hsa049150.71897715
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70897541
97Insulin resistance_Homo sapiens_hsa049310.68987274
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68852454
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68524532
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68433556
101Hedgehog signaling pathway_Homo sapiens_hsa043400.67367290
102MicroRNAs in cancer_Homo sapiens_hsa052060.66152309
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65994040
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65694021
105Thyroid hormone synthesis_Homo sapiens_hsa049180.65659764
106Fatty acid elongation_Homo sapiens_hsa000620.65373565
107Histidine metabolism_Homo sapiens_hsa003400.65314436
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65297703
109Adherens junction_Homo sapiens_hsa045200.65094830
110Oocyte meiosis_Homo sapiens_hsa041140.64426230
111HIF-1 signaling pathway_Homo sapiens_hsa040660.63413509
112Salmonella infection_Homo sapiens_hsa051320.63392950
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63219241
114MAPK signaling pathway_Homo sapiens_hsa040100.62918077
115Insulin signaling pathway_Homo sapiens_hsa049100.62732481
116Phenylalanine metabolism_Homo sapiens_hsa003600.61767034
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.61085313
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.60751693
119beta-Alanine metabolism_Homo sapiens_hsa004100.60398313
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60003664
121Wnt signaling pathway_Homo sapiens_hsa043100.59889072
122Arginine and proline metabolism_Homo sapiens_hsa003300.59236561
123Chemical carcinogenesis_Homo sapiens_hsa052040.59184415
124Glioma_Homo sapiens_hsa052140.58694323
125Melanoma_Homo sapiens_hsa052180.58114068
126Platelet activation_Homo sapiens_hsa046110.57602984
127Fructose and mannose metabolism_Homo sapiens_hsa000510.56382573
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55928781
129ErbB signaling pathway_Homo sapiens_hsa040120.55766208
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55249589
131FoxO signaling pathway_Homo sapiens_hsa040680.54280744
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54254878
133Fat digestion and absorption_Homo sapiens_hsa049750.54202794
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53951291
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53764177
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53608075
137Phagosome_Homo sapiens_hsa041450.53378829
138Sulfur relay system_Homo sapiens_hsa041220.52124923
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51913689
140Glucagon signaling pathway_Homo sapiens_hsa049220.51140606
141Pertussis_Homo sapiens_hsa051330.51015798
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50941725
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50700331
144Basal transcription factors_Homo sapiens_hsa030220.50078278
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.50066046
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.49696835
147Tight junction_Homo sapiens_hsa045300.49112988
148Endocytosis_Homo sapiens_hsa041440.48578643
149Pentose phosphate pathway_Homo sapiens_hsa000300.47452130
150AMPK signaling pathway_Homo sapiens_hsa041520.47297106
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46318352
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.44670136
153Gap junction_Homo sapiens_hsa045400.44395043
154Malaria_Homo sapiens_hsa051440.44103081
155Rap1 signaling pathway_Homo sapiens_hsa040150.42493290
156Renal cell carcinoma_Homo sapiens_hsa052110.42316753
157Oxytocin signaling pathway_Homo sapiens_hsa049210.40172936
158Glutathione metabolism_Homo sapiens_hsa004800.38774115
159Tyrosine metabolism_Homo sapiens_hsa003500.37666430
160Glycerolipid metabolism_Homo sapiens_hsa005610.37370842
161Huntingtons disease_Homo sapiens_hsa050160.35924168
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35015642
163VEGF signaling pathway_Homo sapiens_hsa043700.34620551
164Cysteine and methionine metabolism_Homo sapiens_hsa002700.33438432
165Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32761827

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