FEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.87508912
2DNA unwinding involved in DNA replication (GO:0006268)5.73285631
3* DNA strand elongation (GO:0022616)5.58083631
4* telomere maintenance via semi-conservative replication (GO:0032201)5.41727215
5DNA replication initiation (GO:0006270)5.38482047
6protein localization to kinetochore (GO:0034501)4.84726180
7* telomere maintenance via recombination (GO:0000722)4.76491369
8DNA replication checkpoint (GO:0000076)4.66860318
9* mitotic recombination (GO:0006312)4.58801052
10DNA replication-dependent nucleosome assembly (GO:0006335)4.38386653
11DNA replication-dependent nucleosome organization (GO:0034723)4.38386653
12ribosomal small subunit assembly (GO:0000028)4.31474267
13nucleotide-excision repair, DNA gap filling (GO:0006297)4.27468003
14nucleobase biosynthetic process (GO:0046112)4.22624217
15DNA deamination (GO:0045006)4.20743184
16protein localization to chromosome, centromeric region (GO:0071459)4.18750615
17CENP-A containing nucleosome assembly (GO:0034080)4.16062373
18* telomere maintenance via telomere lengthening (GO:0010833)4.11425554
19chromatin remodeling at centromere (GO:0031055)4.10178803
20maturation of SSU-rRNA (GO:0030490)4.09223154
21folic acid-containing compound biosynthetic process (GO:0009396)4.07653326
22establishment of viral latency (GO:0019043)4.05209819
23mitotic sister chromatid cohesion (GO:0007064)3.99615656
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94381993
25IMP biosynthetic process (GO:0006188)3.92675323
26formation of translation preinitiation complex (GO:0001731)3.92582151
27DNA replication-independent nucleosome organization (GO:0034724)3.86454084
28DNA replication-independent nucleosome assembly (GO:0006336)3.86454084
29purine nucleobase biosynthetic process (GO:0009113)3.83835692
30mitotic nuclear envelope disassembly (GO:0007077)3.83323725
31viral transcription (GO:0019083)3.75239216
32DNA ligation (GO:0006266)3.73609574
33mitotic metaphase plate congression (GO:0007080)3.72331137
34mitotic sister chromatid segregation (GO:0000070)3.69566738
35translational termination (GO:0006415)3.67632106
36kinetochore organization (GO:0051383)3.67084958
37mitotic chromosome condensation (GO:0007076)3.61669097
38DNA topological change (GO:0006265)3.59461696
39IMP metabolic process (GO:0046040)3.55508297
40pore complex assembly (GO:0046931)3.54951764
41nucleobase-containing small molecule interconversion (GO:0015949)3.54420252
42nuclear envelope disassembly (GO:0051081)3.52900867
43membrane disassembly (GO:0030397)3.52900867
44attachment of spindle microtubules to kinetochore (GO:0008608)3.52453164
45double-strand break repair via nonhomologous end joining (GO:0006303)3.51724494
46non-recombinational repair (GO:0000726)3.51724494
47histone exchange (GO:0043486)3.44223725
48ribosomal small subunit biogenesis (GO:0042274)3.44119569
49ribosomal large subunit biogenesis (GO:0042273)3.42911938
50translational elongation (GO:0006414)3.42775071
51DNA duplex unwinding (GO:0032508)3.42742114
52sister chromatid segregation (GO:0000819)3.42120828
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41566880
54DNA geometric change (GO:0032392)3.40354596
55chromosome condensation (GO:0030261)3.39841483
56nuclear pore organization (GO:0006999)3.38832902
57heterochromatin organization (GO:0070828)3.38356913
58ribosome biogenesis (GO:0042254)3.38084785
59ribonucleoprotein complex biogenesis (GO:0022613)3.36630792
60translational initiation (GO:0006413)3.35703588
61regulation of translational fidelity (GO:0006450)3.34112254
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.33295110
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33295110
64ribosome assembly (GO:0042255)3.31917545
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.31852371
66metaphase plate congression (GO:0051310)3.31070291
67chromosome segregation (GO:0007059)3.28577811
68negative regulation of mRNA processing (GO:0050686)3.27857178
69translesion synthesis (GO:0019985)3.27531876
70regulation of centriole replication (GO:0046599)3.24857527
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23136506
72nuclear pore complex assembly (GO:0051292)3.22193301
73rRNA processing (GO:0006364)3.21238315
74spliceosomal snRNP assembly (GO:0000387)3.19580004
75regulation of chromosome segregation (GO:0051983)3.19368945
76chromatin assembly or disassembly (GO:0006333)3.18526023
77kinetochore assembly (GO:0051382)3.18324899
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17440130
79establishment of chromosome localization (GO:0051303)3.17239101
80G1/S transition of mitotic cell cycle (GO:0000082)3.16866972
81cell cycle G1/S phase transition (GO:0044843)3.16866972
82negative regulation of chromosome segregation (GO:0051985)3.16089573
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15993655
84transcription-coupled nucleotide-excision repair (GO:0006283)3.15294947
85cotranslational protein targeting to membrane (GO:0006613)3.14765031
86* telomere organization (GO:0032200)3.14318049
87* telomere maintenance (GO:0000723)3.13274815
88protein targeting to ER (GO:0045047)3.13231090
89protein complex localization (GO:0031503)3.12660964
90establishment of integrated proviral latency (GO:0075713)3.11310623
91postreplication repair (GO:0006301)3.10884620
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10507148
93rRNA metabolic process (GO:0016072)3.09875793
94regulation of sister chromatid cohesion (GO:0007063)3.09813436
95negative regulation of ligase activity (GO:0051352)3.07651844
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07651844
97mismatch repair (GO:0006298)3.06281878
98spindle checkpoint (GO:0031577)3.04640950
99regulation of mitochondrial translation (GO:0070129)3.04400240
100DNA packaging (GO:0006323)3.03122527
101negative regulation of mitotic sister chromatid separation (GO:2000816)3.02524726
102negative regulation of sister chromatid segregation (GO:0033046)3.02524726
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02524726
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02524726
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02524726
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01983652
107DNA synthesis involved in DNA repair (GO:0000731)3.00349188
108meiotic chromosome segregation (GO:0045132)3.00220162
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00161891
110negative regulation of RNA splicing (GO:0033119)2.99436235
111DNA strand renaturation (GO:0000733)2.97786459
112positive regulation of chromosome segregation (GO:0051984)2.97718792
113negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96898111
114establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96821945
115cellular protein complex disassembly (GO:0043624)2.94751890
116DNA conformation change (GO:0071103)2.94010603
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93673576
118ATP-dependent chromatin remodeling (GO:0043044)2.92130622
119protein localization to endoplasmic reticulum (GO:0070972)2.92113415
120deoxyribonucleotide biosynthetic process (GO:0009263)2.91178049
121regulation of spindle organization (GO:0090224)2.90905410
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90771046
123proteasome assembly (GO:0043248)2.89860515
124viral mRNA export from host cell nucleus (GO:0046784)2.89277431
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.88824209
126viral life cycle (GO:0019058)2.88453916
127* mitotic cell cycle (GO:0000278)2.86912643
128pseudouridine synthesis (GO:0001522)2.86863545
129* DNA replication (GO:0006260)2.85093881
130* base-excision repair (GO:0006284)2.84734644
131protein localization to chromosome (GO:0034502)2.84032610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.85519345
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.26690588
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02061991
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99512144
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91456048
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17081742
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95095295
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75673217
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.74506694
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69599886
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65062674
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.54952821
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.54915175
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52161840
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45658141
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35118090
17XRN2_22483619_ChIP-Seq_HELA_Human2.25888673
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24489609
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21523800
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.11768553
21VDR_23849224_ChIP-Seq_CD4+_Human2.11628287
22* AR_21909140_ChIP-Seq_LNCAP_Human2.07933375
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06771564
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02580736
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01034016
26FOXP3_21729870_ChIP-Seq_TREG_Human1.95759414
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.93936806
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91926776
29DCP1A_22483619_ChIP-Seq_HELA_Human1.87943897
30MYC_22102868_ChIP-Seq_BL_Human1.87940321
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86481055
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84603337
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84344299
34GABP_19822575_ChIP-Seq_HepG2_Human1.76506017
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71719214
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71485735
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70797828
38* TTF2_22483619_ChIP-Seq_HELA_Human1.69812609
39CIITA_25753668_ChIP-Seq_RAJI_Human1.68366624
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65433245
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60790017
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56751761
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54970176
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50529317
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49912007
46ELK1_19687146_ChIP-ChIP_HELA_Human1.47026399
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.46156538
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43573053
49* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42881212
50* VDR_21846776_ChIP-Seq_THP-1_Human1.41139835
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40695174
52KDM5A_27292631_Chip-Seq_BREAST_Human1.40451137
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38482572
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37807890
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36379774
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35588443
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34056934
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33530467
59* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31899394
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31418893
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30526003
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.26066185
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21587573
64ZNF263_19887448_ChIP-Seq_K562_Human1.20353404
65TFEB_21752829_ChIP-Seq_HELA_Human1.14181236
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12505243
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11968254
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10165241
69* SPI1_23547873_ChIP-Seq_NB4_Human1.09770834
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09367453
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05106456
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04483541
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03758518
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01108978
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00589032
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99847841
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99726440
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99392933
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99130521
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98111602
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97404324
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95726248
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94044546
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91991771
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91801175
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91625079
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90534672
88MYC_18940864_ChIP-ChIP_HL60_Human0.90093435
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.89691046
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.89632696
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88851427
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88721117
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88697786
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86691013
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86324147
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85867587
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84830727
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84176622
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84146150
100* SOX17_20123909_ChIP-Seq_XEN_Mouse0.83609377
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83391072
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82858512
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82160778
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77554829
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77430959
106UTX_26944678_Chip-Seq_JUKART_Human0.77124733
107CHD1_26751641_Chip-Seq_LNCaP_Human0.76669078
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76356378
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76248170
110MYB_26560356_Chip-Seq_TH2_Human0.74854874
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.74838990
112SCL_19346495_ChIP-Seq_HPC-7_Human0.74799766
113* MAF_26560356_Chip-Seq_TH1_Human0.73946599
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73108830
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72753664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.44952346
2MP0010094_abnormal_chromosome_stability5.18334447
3MP0003111_abnormal_nucleus_morphology4.78807631
4* MP0004957_abnormal_blastocyst_morpholog4.41416206
5MP0003077_abnormal_cell_cycle4.23274555
6* MP0008057_abnormal_DNA_replication3.18197495
7* MP0008058_abnormal_DNA_repair3.11059857
8MP0002396_abnormal_hematopoietic_system2.98603789
9MP0008007_abnormal_cellular_replicative2.89134662
10MP0008932_abnormal_embryonic_tissue2.68530619
11MP0001730_embryonic_growth_arrest2.38070467
12MP0010352_gastrointestinal_tract_polyps2.31976930
13MP0010307_abnormal_tumor_latency2.29002618
14* MP0000350_abnormal_cell_proliferation2.28729233
15* MP0000490_abnormal_crypts_of1.99763143
16MP0003123_paternal_imprinting1.92657990
17MP0002877_abnormal_melanocyte_morpholog1.83865127
18MP0003786_premature_aging1.83117003
19MP0006054_spinal_hemorrhage1.81796509
20MP0009697_abnormal_copulation1.79264481
21MP0004808_abnormal_hematopoietic_stem1.76955800
22MP0009333_abnormal_splenocyte_physiolog1.75921673
23MP0008877_abnormal_DNA_methylation1.73938368
24* MP0002019_abnormal_tumor_incidence1.69185434
25MP0002398_abnormal_bone_marrow1.65643631
26MP0001545_abnormal_hematopoietic_system1.63967969
27MP0005397_hematopoietic_system_phenotyp1.63967969
28* MP0000313_abnormal_cell_death1.62352176
29* MP0002080_prenatal_lethality1.61466673
30* MP0001697_abnormal_embryo_size1.58946249
31MP0003763_abnormal_thymus_physiology1.57233832
32MP0006035_abnormal_mitochondrial_morpho1.54405043
33* MP0005380_embryogenesis_phenotype1.53812917
34* MP0001672_abnormal_embryogenesis/_devel1.53812917
35MP0004147_increased_porphyrin_level1.49041004
36MP0003656_abnormal_erythrocyte_physiolo1.46909495
37* MP0002722_abnormal_immune_system1.45921521
38* MP0000689_abnormal_spleen_morphology1.44110976
39* MP0000703_abnormal_thymus_morphology1.43118752
40* MP0003984_embryonic_growth_retardation1.38528089
41MP0010030_abnormal_orbit_morphology1.36869376
42MP0001346_abnormal_lacrimal_gland1.35083890
43* MP0002088_abnormal_embryonic_growth/wei1.34422964
44MP0001835_abnormal_antigen_presentation1.33741427
45MP0006292_abnormal_olfactory_placode1.31179322
46* MP0002085_abnormal_embryonic_tissue1.30571984
47* MP0002429_abnormal_blood_cell1.29866377
48MP0005076_abnormal_cell_differentiation1.29011236
49MP0003806_abnormal_nucleotide_metabolis1.28799366
50MP0004185_abnormal_adipocyte_glucose1.25321247
51* MP0002086_abnormal_extraembryonic_tissu1.22814091
52MP0003567_abnormal_fetal_cardiomyocyte1.22128056
53MP0004197_abnormal_fetal_growth/weight/1.21635497
54MP0000372_irregular_coat_pigmentation1.21531302
55MP0004233_abnormal_muscle_weight1.21206180
56MP0000716_abnormal_immune_system1.17457434
57MP0002084_abnormal_developmental_patter1.15782452
58MP0005501_abnormal_skin_physiology1.15764831
59MP0000858_altered_metastatic_potential1.15232968
60MP0003941_abnormal_skin_development1.14775813
61MP0001800_abnormal_humoral_immune1.11959227
62MP0003718_maternal_effect1.09112010
63MP0001853_heart_inflammation1.08100506
64MP0000537_abnormal_urethra_morphology1.07394244
65MP0002420_abnormal_adaptive_immunity1.06278029
66MP0001819_abnormal_immune_cell1.03997253
67MP0003705_abnormal_hypodermis_morpholog1.02587348
68MP0002452_abnormal_antigen_presenting1.01419535
69MP0002210_abnormal_sex_determination0.99663893
70MP0002697_abnormal_eye_size0.98959036
71MP0000685_abnormal_immune_system0.98708241
72MP0000358_abnormal_cell_content/0.97314050
73MP0000465_gastrointestinal_hemorrhage0.96684312
74MP0005671_abnormal_response_to0.95909150
75MP0003890_abnormal_embryonic-extraembry0.94893734
76MP0003937_abnormal_limbs/digits/tail_de0.93535233
77MP0003186_abnormal_redox_activity0.92956428
78MP0003121_genomic_imprinting0.92393916
79MP0001145_abnormal_male_reproductive0.91778284
80MP0001727_abnormal_embryo_implantation0.91260752
81MP0001661_extended_life_span0.89101292
82MP0002723_abnormal_immune_serum0.88671466
83MP0002163_abnormal_gland_morphology0.87155818
84MP0001293_anophthalmia0.86968440
85MP0005451_abnormal_body_composition0.86379270
86MP0002405_respiratory_system_inflammati0.86257613
87MP0002938_white_spotting0.83641181
88MP0009278_abnormal_bone_marrow0.82927587
89MP0001929_abnormal_gametogenesis0.82144997
90MP0002132_abnormal_respiratory_system0.81870556
91MP0005025_abnormal_response_to0.81719668
92* MP0005384_cellular_phenotype0.81435293
93MP0002095_abnormal_skin_pigmentation0.80156402
94MP0005000_abnormal_immune_tolerance0.79990031
95MP0005408_hypopigmentation0.79240218
96MP0003436_decreased_susceptibility_to0.78982546
97MP0005171_absent_coat_pigmentation0.77204651
98* MP0005621_abnormal_cell_physiology0.77029974
99MP0005023_abnormal_wound_healing0.76805818
100MP0005174_abnormal_tail_pigmentation0.76715933
101MP0009703_decreased_birth_body0.76260947
102MP0010234_abnormal_vibrissa_follicle0.75856179
103MP0001915_intracranial_hemorrhage0.73989597
104MP0000653_abnormal_sex_gland0.73542352
105MP0003221_abnormal_cardiomyocyte_apopto0.73130166
106MP0009672_abnormal_birth_weight0.72761712
107MP0009785_altered_susceptibility_to0.71866697
108MP0002092_abnormal_eye_morphology0.71846313
109MP0001286_abnormal_eye_development0.71763465
110MP0005075_abnormal_melanosome_morpholog0.71356306
111MP0002796_impaired_skin_barrier0.70924319
112MP0003943_abnormal_hepatobiliary_system0.70219188
113MP0005464_abnormal_platelet_physiology0.69885630
114MP0006036_abnormal_mitochondrial_physio0.69853981
115MP0002166_altered_tumor_susceptibility0.69251768
116* MP0000477_abnormal_intestine_morphology0.68115337
117MP0002160_abnormal_reproductive_system0.67941920
118MP0001529_abnormal_vocalization0.67743755
119MP0003866_abnormal_defecation0.67447716
120MP0003448_altered_tumor_morphology0.65036149
121MP0003699_abnormal_female_reproductive0.64902581
122MP0010155_abnormal_intestine_physiology0.64610006
123MP0001881_abnormal_mammary_gland0.63979546
124MP0002006_tumorigenesis0.62979633
125MP0003303_peritoneal_inflammation0.61779229
126MP0003566_abnormal_cell_adhesion0.61435649
127MP0002111_abnormal_tail_morphology0.60653639
128MP0003315_abnormal_perineum_morphology0.60631088
129MP0001119_abnormal_female_reproductive0.60002620
130MP0005623_abnormal_meninges_morphology0.59611885
131MP0002161_abnormal_fertility/fecundity0.58621206
132MP0002419_abnormal_innate_immunity0.57937850
133MP0009379_abnormal_foot_pigmentation0.57027959
134MP0000428_abnormal_craniofacial_morphol0.55020834
135MP0001186_pigmentation_phenotype0.54315493
136* MP0003861_abnormal_nervous_system0.53479715
137MP0003136_yellow_coat_color0.53417070
138MP0008995_early_reproductive_senescence0.53286411
139MP0008789_abnormal_olfactory_epithelium0.52171776
140MP0001849_ear_inflammation0.50931024
141MP0003698_abnormal_male_reproductive0.50701561
142MP0009053_abnormal_anal_canal0.50349805
143MP0003385_abnormal_body_wall0.50209055
144MP0000627_abnormal_mammary_gland0.48174089

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.26888251
2Abnormality of cells of the erythroid lineage (HP:0012130)4.71145944
3Abnormal number of erythroid precursors (HP:0012131)4.66071984
4Reticulocytopenia (HP:0001896)4.47885062
5Chromsome breakage (HP:0040012)3.96676154
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86117384
7Breast hypoplasia (HP:0003187)3.65921024
8Microvesicular hepatic steatosis (HP:0001414)3.48062046
9Agnosia (HP:0010524)3.41570381
10Oral leukoplakia (HP:0002745)3.37618137
11Aplastic anemia (HP:0001915)3.35573980
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.22791599
13Abnormality of chromosome stability (HP:0003220)3.18822068
14Abnormality of glycolysis (HP:0004366)3.18283093
15Colon cancer (HP:0003003)3.16247587
16Abnormality of the preputium (HP:0100587)3.15530654
17Patellar aplasia (HP:0006443)3.14103629
18Selective tooth agenesis (HP:0001592)3.13817498
19Meckel diverticulum (HP:0002245)3.11645923
20Medulloblastoma (HP:0002885)3.02785954
21Abnormality of the ileum (HP:0001549)2.99605025
22Ependymoma (HP:0002888)2.98631991
23Pallor (HP:0000980)2.93944673
24Macrocytic anemia (HP:0001972)2.92978388
25Aplasia/Hypoplasia of the patella (HP:0006498)2.91739650
26Degeneration of anterior horn cells (HP:0002398)2.90067651
27Abnormality of the anterior horn cell (HP:0006802)2.90067651
28Increased serum pyruvate (HP:0003542)2.89021100
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.87925182
30Myelodysplasia (HP:0002863)2.84278506
31Thrombocytosis (HP:0001894)2.82542481
32Carpal bone hypoplasia (HP:0001498)2.79798634
33Progressive muscle weakness (HP:0003323)2.76423921
34IgM deficiency (HP:0002850)2.72524573
35Microretrognathia (HP:0000308)2.70733409
36Duodenal stenosis (HP:0100867)2.69136335
37Small intestinal stenosis (HP:0012848)2.69136335
38Rough bone trabeculation (HP:0100670)2.64262389
39Bone marrow hypocellularity (HP:0005528)2.63459880
40Absent thumb (HP:0009777)2.62176774
4111 pairs of ribs (HP:0000878)2.54656882
42Basal cell carcinoma (HP:0002671)2.50071463
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.48170724
44Cerebral hypomyelination (HP:0006808)2.46215343
45Premature graying of hair (HP:0002216)2.45085898
46Neoplasm of the pancreas (HP:0002894)2.42700800
47Lymphoma (HP:0002665)2.40269488
48Abnormality of reticulocytes (HP:0004312)2.39580919
49Abnormal mitochondria in muscle tissue (HP:0008316)2.37134377
50Nephroblastoma (Wilms tumor) (HP:0002667)2.35768961
51Multiple enchondromatosis (HP:0005701)2.33510996
52Rhabdomyosarcoma (HP:0002859)2.31973009
53Cholecystitis (HP:0001082)2.28885277
54Abnormal gallbladder physiology (HP:0012438)2.28885277
55Ragged-red muscle fibers (HP:0003200)2.27680236
56Impulsivity (HP:0100710)2.25500357
57Cellular immunodeficiency (HP:0005374)2.25400018
58Cortical dysplasia (HP:0002539)2.24493030
59High pitched voice (HP:0001620)2.24083522
60Duplicated collecting system (HP:0000081)2.23611087
61Slender long bone (HP:0003100)2.23328421
62Sloping forehead (HP:0000340)2.22364980
63Embryonal renal neoplasm (HP:0011794)2.20217250
64Acute encephalopathy (HP:0006846)2.19694804
65Tracheoesophageal fistula (HP:0002575)2.19218866
66Abnormal number of incisors (HP:0011064)2.18463336
67Acute necrotizing encephalopathy (HP:0006965)2.17703486
68Abnormality of the duodenum (HP:0002246)2.14297395
69Trismus (HP:0000211)2.14295757
70Increased nuchal translucency (HP:0010880)2.14076163
71Amaurosis fugax (HP:0100576)2.13602841
72Absent radius (HP:0003974)2.13459633
73Progressive external ophthalmoplegia (HP:0000590)2.10508208
74Pancytopenia (HP:0001876)2.10175586
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09171756
76Cafe-au-lait spot (HP:0000957)2.08242454
77Abnormality of the carotid arteries (HP:0005344)2.07457420
78Increased serum lactate (HP:0002151)2.06138491
79Atresia of the external auditory canal (HP:0000413)2.05084709
80Abnormality of the labia minora (HP:0012880)2.04528169
81Abnormality of T cell physiology (HP:0011840)2.04408119
82Squamous cell carcinoma (HP:0002860)2.03130760
83Clubbing of toes (HP:0100760)2.02953354
84Abnormality of cochlea (HP:0000375)2.02088884
85Type I transferrin isoform profile (HP:0003642)2.01950612
86Petechiae (HP:0000967)2.01863939
87Abnormal lung lobation (HP:0002101)2.01838069
88Increased CSF lactate (HP:0002490)2.01343588
89Proximal placement of thumb (HP:0009623)2.00387793
90Abnormality of the umbilical cord (HP:0010881)1.98353711
91Facial cleft (HP:0002006)1.97901704
92Increased hepatocellular lipid droplets (HP:0006565)1.97206812
93Hepatocellular necrosis (HP:0001404)1.96461448
94Overlapping toe (HP:0001845)1.95993114
95Aplasia involving forearm bones (HP:0009822)1.95795280
96Absent forearm bone (HP:0003953)1.95795280
97Choanal atresia (HP:0000453)1.95209991
98Horseshoe kidney (HP:0000085)1.94482158
99Insomnia (HP:0100785)1.93891079
100Triphalangeal thumb (HP:0001199)1.93771115
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93565255
102Prominent nose (HP:0000448)1.92820430
103Ectopic kidney (HP:0000086)1.92548462
104Postnatal microcephaly (HP:0005484)1.91974676
105Deviation of the thumb (HP:0009603)1.91086361
106Overriding aorta (HP:0002623)1.90014706
107Cleft eyelid (HP:0000625)1.89934188
108Hyperacusis (HP:0010780)1.88551459
109Duplication of thumb phalanx (HP:0009942)1.88424256
110Cerebral edema (HP:0002181)1.88378835
111Poor head control (HP:0002421)1.87329954
112Abnormality of T cells (HP:0002843)1.87024267
113Abnormality of the renal collecting system (HP:0004742)1.84282080
114Abnormality of pyrimidine metabolism (HP:0004353)1.84012033
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82656485
116Absent epiphyses (HP:0010577)1.82656485
117Lipid accumulation in hepatocytes (HP:0006561)1.81224434
118Chronic otitis media (HP:0000389)1.80933974
119Arteriovenous malformation (HP:0100026)1.80751150
120Leukopenia (HP:0001882)1.80025315
121Increased intramyocellular lipid droplets (HP:0012240)1.78900101
122Abnormal trabecular bone morphology (HP:0100671)1.78811357
123Abnormal umbilical cord blood vessels (HP:0011403)1.77760743
124Single umbilical artery (HP:0001195)1.77760743
125Abnormality of the fetal cardiovascular system (HP:0010948)1.77760743
126Recurrent viral infections (HP:0004429)1.77194289
127Abnormality of DNA repair (HP:0003254)1.75836130
128Poikiloderma (HP:0001029)1.75737152
129Broad distal phalanx of finger (HP:0009836)1.75615567
130Glossoptosis (HP:0000162)1.75203744
131Mitochondrial inheritance (HP:0001427)1.75194641
132Aplasia/Hypoplasia of the thymus (HP:0010515)1.74912434
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.74105355
134Short thumb (HP:0009778)1.73006384
135Neoplasm of the colon (HP:0100273)1.72874224
136Premature ovarian failure (HP:0008209)1.72436967
137Secondary amenorrhea (HP:0000869)1.72347577
138Abnormality of the astrocytes (HP:0100707)1.71832362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.84573069
2BUB14.36370893
3WEE14.15220238
4VRK23.73767528
5EIF2AK13.09002542
6NEK22.67841701
7SMG12.45124401
8EIF2AK32.41439596
9NEK12.23547617
10NME22.22346936
11TESK22.17659163
12SRPK12.16817449
13VRK12.15969595
14ACVR1B2.09713425
15TTK2.08927345
16STK162.04469508
17BRSK22.00393618
18TSSK61.99250833
19PASK1.96263054
20EEF2K1.95465972
21SCYL21.87496797
22TLK11.87144297
23PLK11.83783280
24ATR1.74550285
25MAP4K11.72927180
26PLK41.67149165
27AURKB1.64200761
28CDK71.56769783
29BRSK11.56649432
30RPS6KB21.54789858
31MKNK11.53364756
32CCNB11.49458207
33STK101.49285767
34TAF11.48494934
35RPS6KA41.46568649
36MAP3K81.40399475
37CDK41.39043264
38MAP3K101.37852407
39STK41.31315797
40PLK31.26592626
41AURKA1.26180619
42DYRK31.23991836
43CHEK21.21489968
44NME11.12185144
45TGFBR11.10396881
46* CHEK11.09575500
47PDK21.09383610
48PAK41.09209147
49IRAK31.00959825
50CDK120.99310353
51PIM20.97952550
52LRRK20.96526641
53CLK10.95809619
54PIM10.95240037
55KDR0.90794228
56TESK10.90140413
57BLK0.86554808
58FLT30.86547073
59TRIM280.85772343
60MKNK20.84912882
61ICK0.82594967
62ZAK0.82328629
63MST1R0.81950585
64PKN20.78615436
65ATM0.78457824
66CDK20.77581728
67BTK0.76807623
68EIF2AK20.75208005
69PAK10.67440108
70MAP3K110.67180950
71BCKDK0.64896025
72CSF1R0.63856725
73CSNK2A20.63660008
74GRK60.63171170
75ARAF0.63151610
76CSNK2A10.61335534
77MAP2K30.60094821
78KIT0.57799222
79ALK0.57529016
80CDK80.56366591
81* CDK10.55611853
82CSNK1G30.54828661
83TEC0.54009730
84EPHA20.53981674
85ERBB40.52410257
86ZAP700.51122430
87CDK150.50078120
88CDK180.50016366
89RPS6KA50.50013751
90IRAK40.48971254
91TRIB30.48492311
92CDK60.48154795
93PBK0.48082077
94PRPF4B0.47818301
95SYK0.47058053
96NUAK10.46626313
97MAPKAPK30.46467797
98DAPK10.46007928
99CDK140.45714140
100LYN0.45396449
101TYK20.44726242
102CDK90.44391481
103CSNK1G10.44323496
104MELK0.44149895
105TAOK20.43718213
106PNCK0.42411641
107MAPKAPK50.39075002
108CSNK1A1L0.38944735
109LIMK10.37351200
110CSNK1E0.36668157
111JAK30.34610259
112ILK0.34247240
113BRD40.33655138
114MST40.33236828
115BRAF0.32462717
116PRKCI0.32326305
117RAF10.31623319
118MAPK110.30918959
119LATS20.27857658
120MTOR0.27692246
121CDK190.26474732
122PRKDC0.26113970
123YES10.24402377
124CDK11A0.24101466
125RPS6KA60.23117335
126LCK0.22810858
127MAPKAPK20.22343050
128AKT20.22330468
129RPS6KL10.21166864
130RPS6KC10.21166864

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.90307396
2Mismatch repair_Homo sapiens_hsa034304.88849119
3Ribosome_Homo sapiens_hsa030103.36513752
4Homologous recombination_Homo sapiens_hsa034403.26302526
5Spliceosome_Homo sapiens_hsa030403.23315039
6Proteasome_Homo sapiens_hsa030503.17516644
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16966130
8* Base excision repair_Homo sapiens_hsa034103.15106744
9Nucleotide excision repair_Homo sapiens_hsa034203.06133348
10One carbon pool by folate_Homo sapiens_hsa006702.77963478
11RNA transport_Homo sapiens_hsa030132.77191570
12Cell cycle_Homo sapiens_hsa041102.77080519
13RNA polymerase_Homo sapiens_hsa030202.57307410
14Pyrimidine metabolism_Homo sapiens_hsa002402.40428660
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37308649
16Fanconi anemia pathway_Homo sapiens_hsa034602.30193759
17RNA degradation_Homo sapiens_hsa030181.68149688
18* Non-homologous end-joining_Homo sapiens_hsa034501.57698568
19Systemic lupus erythematosus_Homo sapiens_hsa053221.54706457
20Basal transcription factors_Homo sapiens_hsa030221.51233865
21p53 signaling pathway_Homo sapiens_hsa041151.51185993
22mRNA surveillance pathway_Homo sapiens_hsa030151.40297823
23Pyruvate metabolism_Homo sapiens_hsa006201.29866831
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22971874
25Purine metabolism_Homo sapiens_hsa002301.20760787
26Antigen processing and presentation_Homo sapiens_hsa046121.17624973
27Epstein-Barr virus infection_Homo sapiens_hsa051691.17135983
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14482274
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06936526
30Fatty acid elongation_Homo sapiens_hsa000621.06349526
31Viral carcinogenesis_Homo sapiens_hsa052031.06205192
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05323532
33Pentose phosphate pathway_Homo sapiens_hsa000301.03707695
34Herpes simplex infection_Homo sapiens_hsa051680.99572931
35Oxidative phosphorylation_Homo sapiens_hsa001900.97875770
36Primary immunodeficiency_Homo sapiens_hsa053400.97303772
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92445195
38Selenocompound metabolism_Homo sapiens_hsa004500.82378082
39Biosynthesis of amino acids_Homo sapiens_hsa012300.80262005
40Oocyte meiosis_Homo sapiens_hsa041140.79921255
41N-Glycan biosynthesis_Homo sapiens_hsa005100.78477441
42Steroid biosynthesis_Homo sapiens_hsa001000.77629306
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77201234
44Protein export_Homo sapiens_hsa030600.75728763
45Legionellosis_Homo sapiens_hsa051340.75011157
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74457997
47HTLV-I infection_Homo sapiens_hsa051660.73546184
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.72371877
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.71727345
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71537729
51Folate biosynthesis_Homo sapiens_hsa007900.68109817
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67955289
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.66760944
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62193905
55Sulfur relay system_Homo sapiens_hsa041220.58663304
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58608226
57Apoptosis_Homo sapiens_hsa042100.57591456
58Small cell lung cancer_Homo sapiens_hsa052220.57202051
59Alcoholism_Homo sapiens_hsa050340.56472541
60Measles_Homo sapiens_hsa051620.56301606
61Lysine degradation_Homo sapiens_hsa003100.55287112
62Alzheimers disease_Homo sapiens_hsa050100.53808684
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50361699
64Glutathione metabolism_Homo sapiens_hsa004800.49434900
65Thyroid cancer_Homo sapiens_hsa052160.48320379
66Hepatitis B_Homo sapiens_hsa051610.48089699
67MicroRNAs in cancer_Homo sapiens_hsa052060.45933221
68Carbon metabolism_Homo sapiens_hsa012000.45161996
69Propanoate metabolism_Homo sapiens_hsa006400.44310876
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43979771
71Shigellosis_Homo sapiens_hsa051310.43312314
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41704091
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41011848
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40590382
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.40496410
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40248728
77Vitamin B6 metabolism_Homo sapiens_hsa007500.38921055
78Fatty acid metabolism_Homo sapiens_hsa012120.38737318
79Hematopoietic cell lineage_Homo sapiens_hsa046400.37645485
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36997950
81Huntingtons disease_Homo sapiens_hsa050160.35326114
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33684744
83Chronic myeloid leukemia_Homo sapiens_hsa052200.33254950
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.31694494
85Colorectal cancer_Homo sapiens_hsa052100.31588314
86Viral myocarditis_Homo sapiens_hsa054160.30390767
87Arginine and proline metabolism_Homo sapiens_hsa003300.29521504
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29296509
89Influenza A_Homo sapiens_hsa051640.28891368
90B cell receptor signaling pathway_Homo sapiens_hsa046620.28438170
91Leishmaniasis_Homo sapiens_hsa051400.27912599
92Parkinsons disease_Homo sapiens_hsa050120.27435089
93Renin-angiotensin system_Homo sapiens_hsa046140.27080429
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25513932
95Galactose metabolism_Homo sapiens_hsa000520.24180854
96Fructose and mannose metabolism_Homo sapiens_hsa000510.23383879
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23334665
98Acute myeloid leukemia_Homo sapiens_hsa052210.22856103
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22597577
100Prostate cancer_Homo sapiens_hsa052150.22021396
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21930402
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21864638
103Hippo signaling pathway_Homo sapiens_hsa043900.20552462
104Bladder cancer_Homo sapiens_hsa052190.20338988
105HIF-1 signaling pathway_Homo sapiens_hsa040660.19416327
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18731355
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17020698
108Notch signaling pathway_Homo sapiens_hsa043300.16906753
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16397511
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16389938
111TGF-beta signaling pathway_Homo sapiens_hsa043500.16213982
112Non-small cell lung cancer_Homo sapiens_hsa052230.15929345
113Metabolic pathways_Homo sapiens_hsa011000.15441050
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.15439737
115Basal cell carcinoma_Homo sapiens_hsa052170.14499697
116Pancreatic cancer_Homo sapiens_hsa052120.13799579
117Asthma_Homo sapiens_hsa053100.13613755
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13528128
119Other glycan degradation_Homo sapiens_hsa005110.12780003
120Allograft rejection_Homo sapiens_hsa053300.11827232
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11739613
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10858594
123Arginine biosynthesis_Homo sapiens_hsa002200.10414694
124Pathways in cancer_Homo sapiens_hsa052000.10026846
125Melanoma_Homo sapiens_hsa052180.08433675
126Vibrio cholerae infection_Homo sapiens_hsa051100.05558368
127Wnt signaling pathway_Homo sapiens_hsa043100.05387528
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04767159

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