FDX1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)6.41947922
2adaptation of signaling pathway (GO:0023058)5.22203534
3protein localization to kinetochore (GO:0034501)5.07581210
4mitochondrial calcium ion transport (GO:0006851)4.70868208
5regulation of chromatin binding (GO:0035561)4.69450664
6histone H2A monoubiquitination (GO:0035518)4.64428270
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.40223383
8protein localization to chromosome, centromeric region (GO:0071459)4.11178057
9regulation of gamma-delta T cell differentiation (GO:0045586)3.97484462
10positive thymic T cell selection (GO:0045059)3.97093385
11positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.74526194
12pinocytosis (GO:0006907)3.68659444
13pyrimidine nucleotide catabolic process (GO:0006244)3.68271338
14ribosomal small subunit assembly (GO:0000028)3.68250194
15cellular defense response (GO:0006968)3.66563749
16GTP biosynthetic process (GO:0006183)3.60593187
17regulation of T cell chemotaxis (GO:0010819)3.60021028
18positive regulation of T cell chemotaxis (GO:0010820)3.60021028
19inner mitochondrial membrane organization (GO:0007007)3.54377147
20UTP metabolic process (GO:0046051)3.51212312
21negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.49418127
22maturation of SSU-rRNA (GO:0030490)3.48682516
23UTP biosynthetic process (GO:0006228)3.48014580
24energy homeostasis (GO:0097009)3.47992140
25receptor guanylyl cyclase signaling pathway (GO:0007168)3.45955909
26sphingosine metabolic process (GO:0006670)3.39280300
27regulation of gamma-delta T cell activation (GO:0046643)3.38305242
28spindle assembly involved in mitosis (GO:0090307)3.23905917
29activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.22498746
30histone H2A ubiquitination (GO:0033522)3.20944052
31histone monoubiquitination (GO:0010390)3.20591155
32cellular response to interleukin-15 (GO:0071350)3.20251034
33positive regulation of cell cycle G1/S phase transition (GO:1902808)3.20216708
34negative regulation of multicellular organism growth (GO:0040015)3.12081897
35termination of RNA polymerase III transcription (GO:0006386)3.10634012
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.10634012
37membrane raft organization (GO:0031579)3.10538346
38L-methionine salvage (GO:0071267)3.08477645
39L-methionine biosynthetic process (GO:0071265)3.08477645
40amino acid salvage (GO:0043102)3.08477645
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06332933
42negative regulation of smooth muscle contraction (GO:0045986)3.04862226
43antigen processing and presentation via MHC class Ib (GO:0002475)2.98823864
44myoblast migration (GO:0051451)2.96838547
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94676631
46microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91719830
47regulation of rhodopsin mediated signaling pathway (GO:0022400)2.90154612
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.86694425
49thrombin receptor signaling pathway (GO:0070493)2.86080391
50ectoderm development (GO:0007398)2.84227727
51interkinetic nuclear migration (GO:0022027)2.82586994
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81122778
53positive regulation of monocyte chemotaxis (GO:0090026)2.80320336
54regulation of transcription from RNA polymerase I promoter (GO:0006356)2.76627018
55response to interleukin-15 (GO:0070672)2.75808933
56negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75725681
57regulation of hypersensitivity (GO:0002883)2.75542897
58diol metabolic process (GO:0034311)2.74738504
59positive regulation of mast cell activation (GO:0033005)2.73375918
60megakaryocyte development (GO:0035855)2.72037463
61oligosaccharide catabolic process (GO:0009313)2.69287631
62lipid storage (GO:0019915)2.64979930
63alpha-beta T cell activation (GO:0046631)2.64778240
64regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64540359
65glycoprotein catabolic process (GO:0006516)2.63322911
66regulation of interleukin-8 secretion (GO:2000482)2.61944117
67regulation of B cell receptor signaling pathway (GO:0050855)2.61633442
68positive T cell selection (GO:0043368)2.59937397
69organic cation transport (GO:0015695)2.59664314
70iron ion import (GO:0097286)2.59440739
71negative thymic T cell selection (GO:0045060)2.59034247
72regulation of response to interferon-gamma (GO:0060330)2.57785425
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55788405
74rhodopsin mediated signaling pathway (GO:0016056)2.53135839
75preassembly of GPI anchor in ER membrane (GO:0016254)2.51501518
76ribosomal large subunit biogenesis (GO:0042273)2.49848755
77mature B cell differentiation involved in immune response (GO:0002313)2.48469670
78protoporphyrinogen IX metabolic process (GO:0046501)2.46684516
79progesterone metabolic process (GO:0042448)2.43223842
80viral transcription (GO:0019083)2.42589756
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.42314127
82Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42303305
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.42262531
84positive regulation of mast cell degranulation (GO:0043306)2.42262531
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41517024
86hormone catabolic process (GO:0042447)2.40700998
87positive regulation of histone acetylation (GO:0035066)2.40582345
88mitotic sister chromatid cohesion (GO:0007064)2.38473674
893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35884569
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35884569
91positive regulation of isotype switching (GO:0045830)2.35080965
92brown fat cell differentiation (GO:0050873)2.33907269
93negative T cell selection (GO:0043383)2.32519637
94negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.32403033
95misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.32215208
96bone resorption (GO:0045453)2.31471216
97ceramide catabolic process (GO:0046514)2.31436347
98negative regulation of insulin receptor signaling pathway (GO:0046627)2.30792451
99cell wall macromolecule catabolic process (GO:0016998)17.1894480
100cell wall macromolecule metabolic process (GO:0044036)14.2628037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.53057061
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85485466
3SCL_19346495_ChIP-Seq_HPC-7_Human3.41827467
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.38125082
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.27891866
6RUNX_20019798_ChIP-Seq_JUKART_Human2.99450600
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75202536
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.61701811
9CIITA_25753668_ChIP-Seq_RAJI_Human2.30110074
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25237569
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19385437
12SPI1_23547873_ChIP-Seq_NB4_Human2.09294350
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.01688685
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.99877104
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99780202
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95569840
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92208909
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.90292224
19LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89006841
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85881208
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85855895
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84670805
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84559043
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84362385
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83842036
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79873549
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78406178
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74718193
29ELK1_19687146_ChIP-ChIP_HELA_Human1.74405339
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71544979
31MYB_26560356_Chip-Seq_TH1_Human1.70930970
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70914708
33GATA3_26560356_Chip-Seq_TH2_Human1.70119349
34VDR_23849224_ChIP-Seq_CD4+_Human1.67062352
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64392888
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62688075
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60827164
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.59374904
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.56141601
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54922213
41MYB_26560356_Chip-Seq_TH2_Human1.54243932
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53022291
43ZNF274_21170338_ChIP-Seq_K562_Hela1.50889178
44GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49037101
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47175636
46IRF1_19129219_ChIP-ChIP_H3396_Human1.45858334
47P53_21459846_ChIP-Seq_SAOS-2_Human1.45644827
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45312296
49DCP1A_22483619_ChIP-Seq_HELA_Human1.45220235
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.44199235
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43909464
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43204857
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39686977
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35780156
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.35115323
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.34987129
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34435589
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.34195662
59FOXP3_21729870_ChIP-Seq_TREG_Human1.33378554
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33285458
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.31389952
62GATA3_27048872_Chip-Seq_THYMUS_Human1.31251246
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30349295
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30304246
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29335971
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28468926
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.27592617
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27592617
69STAT1_20625510_ChIP-Seq_HELA_Human1.26523763
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.26470661
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25026728
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22025865
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.20592108
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.18254472
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17016401
76AR_20517297_ChIP-Seq_VCAP_Human1.14737404
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13247231
78MYC_18940864_ChIP-ChIP_HL60_Human1.12518207
79E2F7_22180533_ChIP-Seq_HELA_Human1.11144611
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10892274
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10422568
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.10341160
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09829546
84IGF1R_20145208_ChIP-Seq_DFB_Human1.09344393
85GATA3_26560356_Chip-Seq_TH1_Human1.09102414
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08635203
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08579556
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08265940
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07852952
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.05827260
91SMRT_27268052_Chip-Seq_Bcells_Human1.05350388
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.05306902
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04661886
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.03478177
95VDR_22108803_ChIP-Seq_LS180_Human1.02482734
96HTT_18923047_ChIP-ChIP_STHdh_Human1.01890450
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01632389
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00344038
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.99574230
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.97986750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.28257160
2MP0006054_spinal_hemorrhage3.79865746
3MP0002102_abnormal_ear_morphology3.56517887
4MP0004147_increased_porphyrin_level3.49489051
5MP0003172_abnormal_lysosome_physiology3.35954699
6MP0009379_abnormal_foot_pigmentation3.28941617
7MP0001835_abnormal_antigen_presentation3.25749972
8MP0003950_abnormal_plasma_membrane2.95451473
9MP0009384_cardiac_valve_regurgitation2.93954049
10MP0005075_abnormal_melanosome_morpholog2.83563760
11MP0002234_abnormal_pharynx_morphology2.82309036
12MP0003724_increased_susceptibility_to2.58523009
13MP0004510_myositis2.50757757
14MP0001853_heart_inflammation2.43669114
15MP0000372_irregular_coat_pigmentation2.36345737
16MP0005671_abnormal_response_to2.24237863
17MP0000013_abnormal_adipose_tissue2.23184558
18MP0002148_abnormal_hypersensitivity_rea2.07652010
19MP0004134_abnormal_chest_morphology1.96524154
20MP0003763_abnormal_thymus_physiology1.86306018
21MP0003786_premature_aging1.85870434
22MP0004233_abnormal_muscle_weight1.80093805
23MP0001873_stomach_inflammation1.75814745
24MP0003656_abnormal_erythrocyte_physiolo1.73070395
25MP0000858_altered_metastatic_potential1.71897030
26MP0005464_abnormal_platelet_physiology1.59007094
27MP0002419_abnormal_innate_immunity1.50444830
28MP0000685_abnormal_immune_system1.50245825
29MP0005000_abnormal_immune_tolerance1.47310856
30MP0001800_abnormal_humoral_immune1.45586749
31MP0003195_calcinosis1.40780316
32MP0005646_abnormal_pituitary_gland1.37484875
33MP0002420_abnormal_adaptive_immunity1.37254562
34MP0002452_abnormal_antigen_presenting1.36157847
35MP0001819_abnormal_immune_cell1.33043320
36MP0005167_abnormal_blood-brain_barrier1.32122264
37MP0002090_abnormal_vision1.30878042
38MP0000681_abnormal_thyroid_gland1.30605031
39MP0005408_hypopigmentation1.30191737
40MP0006292_abnormal_olfactory_placode1.29601811
41MP0002177_abnormal_outer_ear1.29009163
42MP0002998_abnormal_bone_remodeling1.27737811
43MP0000465_gastrointestinal_hemorrhage1.27601172
44MP0005310_abnormal_salivary_gland1.26682815
45MP0002405_respiratory_system_inflammati1.26534097
46MP0000569_abnormal_digit_pigmentation1.25500665
47MP0003690_abnormal_glial_cell1.18145022
48MP0000383_abnormal_hair_follicle1.17966256
49MP0002723_abnormal_immune_serum1.16325388
50MP0002398_abnormal_bone_marrow1.12032031
51MP0001348_abnormal_lacrimal_gland1.10615321
52MP0001756_abnormal_urination1.10330246
53MP0001542_abnormal_bone_strength1.09834182
54MP0002332_abnormal_exercise_endurance1.09760594
55MP0001849_ear_inflammation1.09470234
56MP0003011_delayed_dark_adaptation1.07899734
57MP0000716_abnormal_immune_system1.07459197
58MP0002396_abnormal_hematopoietic_system1.06103701
59MP0001293_anophthalmia1.03047589
60MP0009840_abnormal_foam_cell1.02509434
61MP0005025_abnormal_response_to1.02136777
62MP0002095_abnormal_skin_pigmentation0.99453758
63MP0009785_altered_susceptibility_to0.99042966
64MP0003866_abnormal_defecation0.98287715
65MP0003191_abnormal_cellular_cholesterol0.97703074
66MP0002429_abnormal_blood_cell0.95317294
67MP0005174_abnormal_tail_pigmentation0.92673830
68MP0000689_abnormal_spleen_morphology0.91836894
69MP0003646_muscle_fatigue0.91441658
70MP0003828_pulmonary_edema0.88763746
71MP0009333_abnormal_splenocyte_physiolog0.88576890
72MP0010155_abnormal_intestine_physiology0.88542349
73MP0000647_abnormal_sebaceous_gland0.87978644
74MP0009764_decreased_sensitivity_to0.87843027
75MP0002837_dystrophic_cardiac_calcinosis0.87537532
76MP0001851_eye_inflammation0.87128707
77MP0008057_abnormal_DNA_replication0.87127080
78MP0000613_abnormal_salivary_gland0.86071296
79MP0000015_abnormal_ear_pigmentation0.86062434
80MP0004381_abnormal_hair_follicle0.85064409
81MP0000343_altered_response_to0.84897266
82MP0001790_abnormal_immune_system0.82039772
83MP0005387_immune_system_phenotype0.82039772
84MP0002722_abnormal_immune_system0.81847336
85MP0000678_abnormal_parathyroid_gland0.81397477
86MP0010094_abnormal_chromosome_stability0.80393229
87MP0004947_skin_inflammation0.78584391
88MP0005503_abnormal_tendon_morphology0.78468306
89MP0002229_neurodegeneration0.78415722
90MP0001984_abnormal_olfaction0.78222795
91MP0002009_preneoplasia0.77323461
92MP0005058_abnormal_lysosome_morphology0.77038710
93MP0003303_peritoneal_inflammation0.74496682
94MP0003795_abnormal_bone_structure0.72086125
95MP0000230_abnormal_systemic_arterial0.68809161
96MP0001324_abnormal_eye_pigmentation0.65433497
97MP0008007_abnormal_cellular_replicative0.65281010
98MP0010678_abnormal_skin_adnexa0.63344508
99MP0000428_abnormal_craniofacial_morphol0.62705915
100MP0004084_abnormal_cardiac_muscle0.62343206

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.54579482
2Decreased central vision (HP:0007663)6.35609594
3Cone-rod dystrophy (HP:0000548)5.63257280
4Decreased electroretinogram (ERG) amplitude (HP:0000654)5.37343963
5Abnormality of the renal collecting system (HP:0004742)5.06574752
6Abnormal rod and cone electroretinograms (HP:0008323)5.04451816
7Duplicated collecting system (HP:0000081)4.52738536
8Posterior subcapsular cataract (HP:0007787)4.23727178
9Keratoconus (HP:0000563)4.20824942
10Increased corneal curvature (HP:0100692)4.20824942
11Lip pit (HP:0100267)3.49929974
12Attenuation of retinal blood vessels (HP:0007843)3.33895462
13Microretrognathia (HP:0000308)3.32213454
14J-shaped sella turcica (HP:0002680)3.06365254
15Visual hallucinations (HP:0002367)3.04994547
16IgG deficiency (HP:0004315)3.03724902
17Recurrent abscess formation (HP:0002722)3.00789410
18Loss of speech (HP:0002371)2.91818926
19Progressive neurologic deterioration (HP:0002344)2.89991675
20Limb-girdle muscle atrophy (HP:0003797)2.86959260
21Upper motor neuron abnormality (HP:0002127)2.81594546
22Pustule (HP:0200039)2.73332546
23Stomatitis (HP:0010280)2.68019029
24Abnormality of the vasculature of the conjunctiva (HP:0008054)2.65621352
25Abnormality of midbrain morphology (HP:0002418)2.62409964
26Molar tooth sign on MRI (HP:0002419)2.62409964
27Bony spicule pigmentary retinopathy (HP:0007737)2.53861053
28Subcapsular cataract (HP:0000523)2.52082134
29Abnormality of liposaccharide metabolism (HP:0010968)2.50357417
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.50357417
31Abnormality of glycolipid metabolism (HP:0010969)2.50357417
32Acute lymphatic leukemia (HP:0006721)2.46960110
33Ureteral duplication (HP:0000073)2.46173196
34Reticulocytopenia (HP:0001896)2.45042883
35Focal motor seizures (HP:0011153)2.44366765
36Cerebral palsy (HP:0100021)2.39501402
37Recurrent bacterial skin infections (HP:0005406)2.39305842
38Mucopolysacchariduria (HP:0008155)2.39220894
39Urinary glycosaminoglycan excretion (HP:0003541)2.39220894
40Adactyly (HP:0009776)2.33543508
41Achilles tendon contracture (HP:0001771)2.32409829
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31784588
43Cervical subluxation (HP:0003308)2.30976302
44Constricted visual fields (HP:0001133)2.29714741
45Pseudobulbar signs (HP:0002200)2.29259824
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26254121
47Abnormality of the prostate (HP:0008775)2.25291394
48Myocardial infarction (HP:0001658)2.22773686
49Autoamputation (HP:0001218)2.21377463
50Amyotrophic lateral sclerosis (HP:0007354)2.18298246
51Bifid tongue (HP:0010297)2.17764224
52Ureteral stenosis (HP:0000071)2.16990992
53Increased number of teeth (HP:0011069)2.16300989
54Large for gestational age (HP:0001520)2.15849140
55Ureteral obstruction (HP:0006000)2.13140287
56Rectovaginal fistula (HP:0000143)2.12778082
57Rectal fistula (HP:0100590)2.12778082
58Porencephaly (HP:0002132)2.10647653
59Abnormality of cells of the erythroid lineage (HP:0012130)2.10429627
60Abnormality of the lower motor neuron (HP:0002366)2.10047868
61Beaking of vertebral bodies (HP:0004568)2.07593897
62Combined immunodeficiency (HP:0005387)2.07262479
63Abnormality of polysaccharide metabolism (HP:0011012)2.06838653
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06838653
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06838653
66Concave nail (HP:0001598)2.03447043
67Abnormality of the corticospinal tract (HP:0002492)2.03353303
68Panhypogammaglobulinemia (HP:0003139)2.00496457
69Stenosis of the external auditory canal (HP:0000402)1.99993377
70Abnormality of the costochondral junction (HP:0000919)1.99887705
71Abnormality of the Achilles tendon (HP:0005109)1.97783991
72Deformed sella turcica (HP:0002681)1.96574430
73Failure to thrive in infancy (HP:0001531)1.96492110
74Chest pain (HP:0100749)1.95653256
75Vertebral compression fractures (HP:0002953)1.95192773
76Autoimmune thrombocytopenia (HP:0001973)1.92025833
77Type II lissencephaly (HP:0007260)1.91732766
78Broad face (HP:0000283)1.90981247
79Dysostosis multiplex (HP:0000943)1.87688385
80Pancreatic cysts (HP:0001737)1.85268450
81Abnormal number of erythroid precursors (HP:0012131)1.85108888
82Long foot (HP:0001833)1.84978042
83Retinal dysplasia (HP:0007973)1.84817823
84Wide nose (HP:0000445)1.83869812
85Coxa valga (HP:0002673)1.83222516
86Intestinal fistula (HP:0100819)1.82826872
87Nuclear cataract (HP:0100018)1.82638800
88Abnormal spermatogenesis (HP:0008669)1.80702564
89Pallor (HP:0000980)1.80473776
90Absent phalangeal crease (HP:0006109)1.76061581
91Facial hemangioma (HP:0000329)1.76018078
92Vaginal fistula (HP:0004320)1.75222480
93Severe combined immunodeficiency (HP:0004430)1.74383383
94Lipid accumulation in hepatocytes (HP:0006561)1.72960625
95Optic disc pallor (HP:0000543)1.71821602
96Abnormality of the distal phalanges of the toes (HP:0010182)1.71587149
97Spinal canal stenosis (HP:0003416)1.70220345
98Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69386076
99Short 1st metacarpal (HP:0010034)1.69386076
100Milia (HP:0001056)1.66916742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.21386762
2TAOK34.64169026
3GRK74.43105849
4TGFBR24.28250877
5MOS4.12576380
6BMPR23.13631899
7STK102.86829652
8GRK52.42913783
9RIPK42.34819371
10EIF2AK11.99056200
11NME21.77449627
12EIF2AK21.74273802
13NEK21.73360361
14PRPF4B1.72654121
15ITK1.68462491
16TIE11.66540289
17PRKD31.66167126
18CSF1R1.64564718
19SIK21.62564851
20ACVR1B1.59363886
21FLT31.55405269
22IRAK31.54275810
23CDK191.51453856
24TRPM71.50771936
25SYK1.27394579
26TEC1.25781565
27ERBB31.20644241
28BMPR1B1.17425440
29ADRBK21.09302525
30KIT1.04505784
31DAPK11.02731912
32ADRBK11.01816830
33STK31.01438937
34IGF1R0.93027034
35NUAK10.89810952
36FES0.88152010
37PBK0.87806266
38KDR0.86770971
39LATS10.86197782
40SRPK10.79293400
41ILK0.70904426
42JAK30.69933077
43BTK0.67513773
44SCYL20.66963724
45MAP2K20.65343317
46LCK0.63453914
47TLK10.62272912
48MAP2K30.57160749
49JAK20.56775858
50LYN0.56527516
51IKBKB0.54711500
52PDK10.52920679
53PAK20.51328356
54ABL20.47690021
55MAPK110.42676685
56GRK60.39999404
57NME10.39449473
58TAOK20.38998118
59RPS6KA60.37933820
60MAP4K10.37761912
61STK40.37452068
62AURKA0.37206902
63MATK0.36533849
64RPS6KB20.36507848
65DAPK20.33563467
66HCK0.32066045
67SMG10.32045939
68RPS6KC10.31866812
69RPS6KL10.31866812
70MAP3K120.31806075
71CSK0.31142831
72ABL10.30758939
73MAPKAPK20.30510721
74ZAK0.28299992
75LRRK20.27656629
76PRKG10.26366034
77TGFBR10.25424587
78FYN0.25187207
79PRKACG0.24029859
80FER0.23564553
81PRKCE0.22158315
82MYLK0.21821435
83JAK10.21685052
84PRKCD0.21665137
85OXSR10.21565230
86MAPK100.21549741
87NEK90.21373612
88EGFR0.21094440
89PAK60.21035206
90PLK10.20221181
91PIK3CG0.19160875
92CDK60.19153114
93ZAP700.18350035
94FGFR10.18257241
95CDK70.17736206
96PRKCH0.17566713
97AURKB0.17454303
98PAK10.17070101
99TESK20.15802876
100BLK0.15352018

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.53713517
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.49066375
3Other glycan degradation_Homo sapiens_hsa005113.42183307
4Antigen processing and presentation_Homo sapiens_hsa046123.37408234
5Asthma_Homo sapiens_hsa053103.33855650
6Phototransduction_Homo sapiens_hsa047443.28622192
7Graft-versus-host disease_Homo sapiens_hsa053322.75563581
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74250835
9Allograft rejection_Homo sapiens_hsa053302.70144364
10Autoimmune thyroid disease_Homo sapiens_hsa053202.65073965
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.41158831
12Ribosome_Homo sapiens_hsa030102.40026848
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31225700
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.28121977
15RNA polymerase_Homo sapiens_hsa030202.22263866
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01292286
17Olfactory transduction_Homo sapiens_hsa047401.83244090
18Viral myocarditis_Homo sapiens_hsa054161.75776780
19Pyrimidine metabolism_Homo sapiens_hsa002401.65977035
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64286389
21Type I diabetes mellitus_Homo sapiens_hsa049401.60699029
22Staphylococcus aureus infection_Homo sapiens_hsa051501.48708132
23DNA replication_Homo sapiens_hsa030301.46321608
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45919334
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43923035
26Leishmaniasis_Homo sapiens_hsa051401.36896824
27Fatty acid biosynthesis_Homo sapiens_hsa000611.33321954
28Lysosome_Homo sapiens_hsa041421.32697688
29Linoleic acid metabolism_Homo sapiens_hsa005911.27234150
30One carbon pool by folate_Homo sapiens_hsa006701.22660573
31Primary immunodeficiency_Homo sapiens_hsa053401.13905342
32Rheumatoid arthritis_Homo sapiens_hsa053231.12206890
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07603390
34Arachidonic acid metabolism_Homo sapiens_hsa005901.07523266
35Tryptophan metabolism_Homo sapiens_hsa003801.06937018
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03515307
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01716541
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.00204225
39Purine metabolism_Homo sapiens_hsa002300.98520475
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96819827
41Caffeine metabolism_Homo sapiens_hsa002320.93939810
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.93932690
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90883088
44Hematopoietic cell lineage_Homo sapiens_hsa046400.89505389
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87976728
46Chemical carcinogenesis_Homo sapiens_hsa052040.84151402
47Systemic lupus erythematosus_Homo sapiens_hsa053220.82670062
48Ovarian steroidogenesis_Homo sapiens_hsa049130.80708000
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80626216
50Malaria_Homo sapiens_hsa051440.79129824
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.78563285
52Platelet activation_Homo sapiens_hsa046110.75247957
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75074817
54Ether lipid metabolism_Homo sapiens_hsa005650.72986198
55Sulfur metabolism_Homo sapiens_hsa009200.71899723
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70523855
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70180601
58RNA degradation_Homo sapiens_hsa030180.66663636
59Sphingolipid metabolism_Homo sapiens_hsa006000.64466870
60Osteoclast differentiation_Homo sapiens_hsa043800.64170582
61Spliceosome_Homo sapiens_hsa030400.59893194
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58331921
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57831170
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56944526
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53828634
66Salmonella infection_Homo sapiens_hsa051320.52563610
67Taste transduction_Homo sapiens_hsa047420.52358196
68B cell receptor signaling pathway_Homo sapiens_hsa046620.50228167
69Fanconi anemia pathway_Homo sapiens_hsa034600.48915381
70Epstein-Barr virus infection_Homo sapiens_hsa051690.48856177
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48828959
72Nitrogen metabolism_Homo sapiens_hsa009100.42575859
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.41508318
74Salivary secretion_Homo sapiens_hsa049700.41140689
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40904147
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40284765
77Nucleotide excision repair_Homo sapiens_hsa034200.39423904
78Chemokine signaling pathway_Homo sapiens_hsa040620.38734808
79Toxoplasmosis_Homo sapiens_hsa051450.38536966
80Peroxisome_Homo sapiens_hsa041460.37354339
81Phagosome_Homo sapiens_hsa041450.36229187
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35865879
83Vitamin digestion and absorption_Homo sapiens_hsa049770.34885007
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.33549973
85Pyruvate metabolism_Homo sapiens_hsa006200.33266764
86Tuberculosis_Homo sapiens_hsa051520.32229105
87RNA transport_Homo sapiens_hsa030130.32198235
88Measles_Homo sapiens_hsa051620.31934173
89Herpes simplex infection_Homo sapiens_hsa051680.29535301
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27586305
91Cell cycle_Homo sapiens_hsa041100.25677513
92HTLV-I infection_Homo sapiens_hsa051660.23518691
93Lysine degradation_Homo sapiens_hsa003100.19354336
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18836188
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17839073
96Bladder cancer_Homo sapiens_hsa052190.17553539
97Proteasome_Homo sapiens_hsa030500.17366789
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15945205
99Cardiac muscle contraction_Homo sapiens_hsa042600.15829683
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15373670

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