FDPSP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)5.26089417
2peptidyl-histidine modification (GO:0018202)4.79977977
3adenosine metabolic process (GO:0046085)4.69508601
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.48551066
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.48551066
6cellular response to interferon-beta (GO:0035458)4.14378799
7preassembly of GPI anchor in ER membrane (GO:0016254)4.11873960
8adaptation of signaling pathway (GO:0023058)4.06853015
9determination of adult lifespan (GO:0008340)3.91648102
10growth hormone secretion (GO:0030252)3.80848733
11coenzyme catabolic process (GO:0009109)3.76461300
12piRNA metabolic process (GO:0034587)3.67471000
13cellular biogenic amine catabolic process (GO:0042402)3.64212227
14amine catabolic process (GO:0009310)3.64212227
15phenylpropanoid metabolic process (GO:0009698)3.63122153
16L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53996962
17regulation of growth hormone secretion (GO:0060123)3.52473171
18negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.44919802
19nephron tubule morphogenesis (GO:0072078)3.43467446
20nephron epithelium morphogenesis (GO:0072088)3.43467446
21C-terminal protein amino acid modification (GO:0018410)3.41520913
22DNA double-strand break processing (GO:0000729)3.39385045
23C-terminal protein lipidation (GO:0006501)3.31794465
24DNA deamination (GO:0045006)3.30131556
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28622145
26xenobiotic catabolic process (GO:0042178)3.26637871
27renal absorption (GO:0070293)3.25425912
28protein complex biogenesis (GO:0070271)3.23990271
29proteasome assembly (GO:0043248)3.22880759
30signal peptide processing (GO:0006465)3.22676099
31regulation of hexokinase activity (GO:1903299)3.22389977
32regulation of glucokinase activity (GO:0033131)3.22389977
33mitochondrial respiratory chain complex assembly (GO:0033108)3.20887821
34prenylation (GO:0097354)3.19075880
35protein prenylation (GO:0018342)3.19075880
36pyrimidine-containing compound transmembrane transport (GO:0072531)3.14169404
37tryptophan catabolic process (GO:0006569)3.11843320
38indole-containing compound catabolic process (GO:0042436)3.11843320
39indolalkylamine catabolic process (GO:0046218)3.11843320
40intraciliary transport (GO:0042073)3.09977564
41neurotransmitter uptake (GO:0001504)3.06102034
42mannosylation (GO:0097502)3.05982518
43lactate metabolic process (GO:0006089)3.04407368
44rRNA modification (GO:0000154)3.04174821
45resolution of meiotic recombination intermediates (GO:0000712)3.03407634
46rRNA methylation (GO:0031167)3.03372831
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02138774
48platelet dense granule organization (GO:0060155)3.00347851
49mismatch repair (GO:0006298)3.00077603
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99938703
51regulation of cellular amino acid metabolic process (GO:0006521)2.97951934
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97199392
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97199392
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97199392
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94947355
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94947355
57water-soluble vitamin biosynthetic process (GO:0042364)2.94862466
58negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.93397719
59regulation of Golgi to plasma membrane protein transport (GO:0042996)2.93364520
60amino acid salvage (GO:0043102)2.92590657
61L-methionine salvage (GO:0071267)2.92590657
62L-methionine biosynthetic process (GO:0071265)2.92590657
63natural killer cell differentiation (GO:0001779)2.92073789
64kynurenine metabolic process (GO:0070189)2.91292541
65negative regulation of telomere maintenance (GO:0032205)2.90679127
66positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.88217441
67ribonucleoprotein complex disassembly (GO:0032988)2.86559275
68response to interferon-beta (GO:0035456)2.85454798
69transcription elongation from RNA polymerase I promoter (GO:0006362)2.82821017
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82615164
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.82615164
72coenzyme A metabolic process (GO:0015936)2.81754231
73nucleotide transmembrane transport (GO:1901679)2.79512677
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.79169648
75NADH dehydrogenase complex assembly (GO:0010257)2.79169648
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79169648
77signal transduction involved in cell cycle checkpoint (GO:0072395)2.78703253
78cellular ketone body metabolic process (GO:0046950)2.77501735
79respiratory chain complex IV assembly (GO:0008535)2.76257375
80axoneme assembly (GO:0035082)2.75755967
81regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.72836627
82regulation of RIG-I signaling pathway (GO:0039535)2.72423708
83termination of RNA polymerase I transcription (GO:0006363)2.66474431
84GPI anchor biosynthetic process (GO:0006506)2.65673809
85positive regulation of B cell differentiation (GO:0045579)2.61778477
86indolalkylamine metabolic process (GO:0006586)2.61741631
87activation of adenylate cyclase activity (GO:0007190)2.60818662
88succinate metabolic process (GO:0006105)2.60565588
89bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59624870
90cytochrome complex assembly (GO:0017004)2.59237921
91ovulation cycle (GO:0042698)2.58791270
92cullin deneddylation (GO:0010388)2.56792712
93tryptophan metabolic process (GO:0006568)2.55119134
94poly(A)+ mRNA export from nucleus (GO:0016973)2.54261230
95L-glutamate transport (GO:0015813)2.53622117
96phosphatidylglycerol biosynthetic process (GO:0006655)2.52562870
97purine nucleobase biosynthetic process (GO:0009113)2.51988299
98ketone body metabolic process (GO:1902224)2.50856219
99protein deneddylation (GO:0000338)2.50103135
100negative regulation of multicellular organism growth (GO:0040015)2.50009875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10144837
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34071494
3VDR_22108803_ChIP-Seq_LS180_Human3.16438573
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.90605556
5ZNF274_21170338_ChIP-Seq_K562_Hela2.66003026
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54248180
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53528422
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.41204189
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23795159
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.21775630
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19811425
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14714717
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05728583
14ER_23166858_ChIP-Seq_MCF-7_Human2.00564536
15CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99671301
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99311294
17VDR_23849224_ChIP-Seq_CD4+_Human1.96476060
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95623045
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93373997
20ELK1_19687146_ChIP-ChIP_HELA_Human1.86969463
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86272281
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83251975
23GATA1_22025678_ChIP-Seq_K562_Human1.76996406
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.73479570
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.70901608
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.69720055
27FOXP3_21729870_ChIP-Seq_TREG_Human1.66728965
28TAF15_26573619_Chip-Seq_HEK293_Human1.63355056
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60309248
30MYC_18940864_ChIP-ChIP_HL60_Human1.59724122
31GBX2_23144817_ChIP-Seq_PC3_Human1.58785013
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57266260
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55125080
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.55045498
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.54648212
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.53528266
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53320359
38FUS_26573619_Chip-Seq_HEK293_Human1.50089079
39EWS_26573619_Chip-Seq_HEK293_Human1.48952889
40TP53_22573176_ChIP-Seq_HFKS_Human1.46034589
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45718949
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41197486
43IGF1R_20145208_ChIP-Seq_DFB_Human1.38987724
44NANOG_19829295_ChIP-Seq_ESCs_Human1.37113745
45SOX2_19829295_ChIP-Seq_ESCs_Human1.37113745
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.36761077
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34935838
48CBP_20019798_ChIP-Seq_JUKART_Human1.33929064
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33929064
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33599809
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32498322
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31630608
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31184362
54GATA3_26560356_Chip-Seq_TH2_Human1.29635020
55P300_19829295_ChIP-Seq_ESCs_Human1.29568969
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29065602
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.27005290
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23457601
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.21729560
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.19911404
61HOXB7_26014856_ChIP-Seq_BT474_Human1.19865958
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19685221
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19353895
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16416190
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14845556
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12816926
67E2F7_22180533_ChIP-Seq_HELA_Human1.12510888
68PHF8_20622853_ChIP-Seq_HELA_Human1.11276646
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.11115062
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11115062
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10768732
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.10343657
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10038779
74AR_20517297_ChIP-Seq_VCAP_Human1.08445085
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.08143552
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.06416214
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06220431
78P300_18555785_Chip-Seq_ESCs_Mouse1.05689108
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04702694
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04676461
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03047141
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02348899
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.02043444
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.01656109
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.01244023
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.01150030
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00926312
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.00480757
89P53_22387025_ChIP-Seq_ESCs_Mouse1.00211217
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.99373996
91RBPJ_21746931_ChIP-Seq_IB4_Human0.99015966
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.98224250
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98000725
94ZFX_18555785_Chip-Seq_ESCs_Mouse0.97244746
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96721895
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.96590973
97NCOR_22424771_ChIP-Seq_293T_Human0.96352722
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96236172
99GABP_19822575_ChIP-Seq_HepG2_Human0.96002569
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95892210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.22951410
2MP0008057_abnormal_DNA_replication3.10115588
3MP0006035_abnormal_mitochondrial_morpho3.01973280
4MP0008877_abnormal_DNA_methylation2.95653029
5MP0002254_reproductive_system_inflammat2.86364926
6MP0002736_abnormal_nociception_after2.77410052
7MP0002638_abnormal_pupillary_reflex2.59838110
8MP0000015_abnormal_ear_pigmentation2.47903053
9MP0001984_abnormal_olfaction2.44332104
10MP0001529_abnormal_vocalization2.30549317
11MP0006036_abnormal_mitochondrial_physio2.30405936
12MP0006054_spinal_hemorrhage2.29924872
13MP0002909_abnormal_adrenal_gland2.24378306
14MP0004043_abnormal_pH_regulation2.13451795
15MP0006276_abnormal_autonomic_nervous2.13141594
16MP0000372_irregular_coat_pigmentation2.08666350
17MP0001501_abnormal_sleep_pattern2.08450653
18MP0003880_abnormal_central_pattern2.08280142
19MP0001835_abnormal_antigen_presentation2.05402309
20MP0005266_abnormal_metabolism1.97783999
21MP0005075_abnormal_melanosome_morpholog1.91704070
22MP0008058_abnormal_DNA_repair1.91109770
23MP0005671_abnormal_response_to1.88171780
24MP0005551_abnormal_eye_electrophysiolog1.84603893
25MP0002090_abnormal_vision1.80904357
26MP0003806_abnormal_nucleotide_metabolis1.75347632
27MP0008961_abnormal_basal_metabolism1.68565635
28MP0000358_abnormal_cell_content/1.67661125
29MP0008875_abnormal_xenobiotic_pharmacok1.64953858
30MP0008872_abnormal_physiological_respon1.61579646
31MP0001968_abnormal_touch/_nociception1.60066860
32MP0003136_yellow_coat_color1.55920452
33MP0002132_abnormal_respiratory_system1.54126927
34MP0005645_abnormal_hypothalamus_physiol1.51779970
35MP0006072_abnormal_retinal_apoptosis1.50374119
36MP0010094_abnormal_chromosome_stability1.46732770
37MP0003693_abnormal_embryo_hatching1.46197855
38MP0005410_abnormal_fertilization1.43327117
39MP0001905_abnormal_dopamine_level1.39001031
40MP0002166_altered_tumor_susceptibility1.33883377
41MP0005253_abnormal_eye_physiology1.31922627
42MP0002095_abnormal_skin_pigmentation1.31252983
43MP0003172_abnormal_lysosome_physiology1.30041214
44MP0004215_abnormal_myocardial_fiber1.29951972
45MP0003718_maternal_effect1.29063068
46MP0005058_abnormal_lysosome_morphology1.26000547
47MP0005365_abnormal_bile_salt1.24433828
48MP0003195_calcinosis1.24052308
49MP0003786_premature_aging1.22244418
50MP0010329_abnormal_lipoprotein_level1.20294925
51MP0000685_abnormal_immune_system1.19979041
52MP0003221_abnormal_cardiomyocyte_apopto1.14415165
53MP0005464_abnormal_platelet_physiology1.13357292
54MP0002138_abnormal_hepatobiliary_system1.08611820
55MP0009764_decreased_sensitivity_to1.08287967
56MP0001486_abnormal_startle_reflex1.07105567
57MP0001661_extended_life_span1.06054052
58MP0009697_abnormal_copulation1.03418196
59MP0002693_abnormal_pancreas_physiology1.02047494
60MP0004133_heterotaxia1.01898111
61MP0002876_abnormal_thyroid_physiology0.99878896
62MP0000647_abnormal_sebaceous_gland0.99847640
63MP0002163_abnormal_gland_morphology0.99447592
64MP0002332_abnormal_exercise_endurance0.99148674
65MP0005379_endocrine/exocrine_gland_phen0.98722413
66MP0003011_delayed_dark_adaptation0.98052795
67MP0001881_abnormal_mammary_gland0.96603910
68MP0008004_abnormal_stomach_pH0.95198048
69MP0002006_tumorigenesis0.94090179
70MP0003077_abnormal_cell_cycle0.90126850
71MP0002734_abnormal_mechanical_nocicepti0.86718897
72MP0001800_abnormal_humoral_immune0.86328316
73MP0005332_abnormal_amino_acid0.85236628
74MP0000230_abnormal_systemic_arterial0.83334526
75MP0003186_abnormal_redox_activity0.82688531
76MP0001929_abnormal_gametogenesis0.80484997
77MP0003698_abnormal_male_reproductive0.79424549
78MP0005376_homeostasis/metabolism_phenot0.78053595
79MP0009745_abnormal_behavioral_response0.77557182
80MP0009046_muscle_twitch0.75543851
81MP0002229_neurodegeneration0.75271273
82MP0002277_abnormal_respiratory_mucosa0.75054863
83MP0002723_abnormal_immune_serum0.74987126
84MP0001485_abnormal_pinna_reflex0.70598966
85MP0000427_abnormal_hair_cycle0.70341762
86MP0000639_abnormal_adrenal_gland0.69839260
87MP0005167_abnormal_blood-brain_barrier0.69682755
88MP0001293_anophthalmia0.69521829
89MP0002751_abnormal_autonomic_nervous0.66183058
90MP0000383_abnormal_hair_follicle0.65933619
91MP0005310_abnormal_salivary_gland0.65508115
92MP0001970_abnormal_pain_threshold0.65251276
93MP0004085_abnormal_heartbeat0.64941319
94MP0002069_abnormal_eating/drinking_beha0.64442179
95MP0008873_increased_physiological_sensi0.64260934
96MP0002272_abnormal_nervous_system0.63691026
97MP0000631_abnormal_neuroendocrine_gland0.63328564
98MP0002452_abnormal_antigen_presenting0.63085737
99MP0002210_abnormal_sex_determination0.62423375
100MP0003183_abnormal_peptide_metabolism0.61687093

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)5.76149965
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.76149965
3Abnormality of alanine metabolism (HP:0010916)5.76149965
4Sensory axonal neuropathy (HP:0003390)5.30973061
5Progressive inability to walk (HP:0002505)4.25176782
6Aplasia/Hypoplasia of the fovea (HP:0008060)3.25429789
7Hypoplasia of the fovea (HP:0007750)3.25429789
8Pancreatic cysts (HP:0001737)3.14878267
9True hermaphroditism (HP:0010459)3.03760240
10Pancreatic islet-cell hyperplasia (HP:0004510)2.99878216
11Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85715220
12Lipid accumulation in hepatocytes (HP:0006561)2.83436023
13Prostate neoplasm (HP:0100787)2.80498550
14Abnormality of the fovea (HP:0000493)2.78254486
15Acute necrotizing encephalopathy (HP:0006965)2.76788181
16Facial diplegia (HP:0001349)2.74379539
17Large for gestational age (HP:0001520)2.72656024
18Mitochondrial inheritance (HP:0001427)2.69795316
19Abnormality of the prostate (HP:0008775)2.68890622
20Vacuolated lymphocytes (HP:0001922)2.67634718
21Abolished electroretinogram (ERG) (HP:0000550)2.67220651
22Increased CSF lactate (HP:0002490)2.60585302
23Pancreatic fibrosis (HP:0100732)2.56864516
24Abnormality of serum amino acid levels (HP:0003112)2.51390963
25Abnormal mitochondria in muscle tissue (HP:0008316)2.50910696
26Hepatocellular necrosis (HP:0001404)2.49192403
27Inability to walk (HP:0002540)2.45266557
28Nephronophthisis (HP:0000090)2.42742337
29Chronic hepatic failure (HP:0100626)2.42699138
30Insulin-resistant diabetes mellitus (HP:0000831)2.38301107
31Methylmalonic acidemia (HP:0002912)2.38280699
32Severe visual impairment (HP:0001141)2.36350223
33Dyschromatopsia (HP:0007641)2.33965977
34Intestinal atresia (HP:0011100)2.30681687
35Cerebral edema (HP:0002181)2.30077941
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27706390
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27706390
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.27635070
39Acute encephalopathy (HP:0006846)2.26716395
40Progressive macrocephaly (HP:0004481)2.25891266
41Spastic paraparesis (HP:0002313)2.24518307
42Hemiparesis (HP:0001269)2.22201479
43Decreased central vision (HP:0007663)2.17050712
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16551195
45Prominent metopic ridge (HP:0005487)2.14786703
46Distal arthrogryposis (HP:0005684)2.14666989
47Optic disc pallor (HP:0000543)2.11036929
48Aplasia/Hypoplasia of the macula (HP:0008059)2.10234026
49Increased serum lactate (HP:0002151)2.09784963
50Increased hepatocellular lipid droplets (HP:0006565)2.09474753
51Leukodystrophy (HP:0002415)2.07592470
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07250570
53Hepatic necrosis (HP:0002605)2.06843904
54Lactic acidosis (HP:0003128)2.04032438
55Sclerocornea (HP:0000647)2.02518564
56Methylmalonic aciduria (HP:0012120)2.02390273
57Entropion (HP:0000621)2.01406855
58Increased muscle lipid content (HP:0009058)2.00326747
59Anencephaly (HP:0002323)1.99290031
60Abnormality of chloride homeostasis (HP:0011422)1.97900712
61Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95335056
62Attenuation of retinal blood vessels (HP:0007843)1.94723330
63Progressive visual loss (HP:0000529)1.94183981
64Adactyly (HP:0009776)1.93026063
65Palpebral edema (HP:0100540)1.92764805
66IgG deficiency (HP:0004315)1.92384834
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90784743
68Abnormality of the renal cortex (HP:0011035)1.89962350
69Increased cerebral lipofuscin (HP:0011813)1.89800051
70Congenital primary aphakia (HP:0007707)1.89212622
71Growth hormone deficiency (HP:0000824)1.87537244
72Fibular aplasia (HP:0002990)1.87269340
73Keratitis (HP:0000491)1.86083452
74Hyperinsulinemic hypoglycemia (HP:0000825)1.85590338
75Increased intramyocellular lipid droplets (HP:0012240)1.84706184
76Gait imbalance (HP:0002141)1.82968983
77Meckel diverticulum (HP:0002245)1.82625518
78Constricted visual fields (HP:0001133)1.82485492
79Retinal atrophy (HP:0001105)1.82112030
80Atonic seizures (HP:0010819)1.81321826
81Poor speech (HP:0002465)1.81234062
82Medial flaring of the eyebrow (HP:0010747)1.80911381
83Oligomenorrhea (HP:0000876)1.79132021
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.78759807
85Cerebral hypomyelination (HP:0006808)1.78489217
86Aplasia/hypoplasia of the uterus (HP:0008684)1.78214299
87Abnormality of midbrain morphology (HP:0002418)1.78147204
88Molar tooth sign on MRI (HP:0002419)1.78147204
89Abnormality of the ileum (HP:0001549)1.77383020
90Lethargy (HP:0001254)1.75749386
91Renal Fanconi syndrome (HP:0001994)1.75378862
92Congenital hepatic fibrosis (HP:0002612)1.73105975
93Furrowed tongue (HP:0000221)1.72385403
94Abnormality of the metopic suture (HP:0005556)1.72344027
95Polyphagia (HP:0002591)1.71458819
96Occipital encephalocele (HP:0002085)1.71167947
97Postaxial foot polydactyly (HP:0001830)1.70190727
98Pancytopenia (HP:0001876)1.70102223
99Nephrogenic diabetes insipidus (HP:0009806)1.69162084
100Abnormality of the renal medulla (HP:0100957)1.68491018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.59555992
2EIF2AK13.46723637
3PDK23.39640340
4TSSK62.83256877
5TAF12.57869391
6TRIM282.43247453
7PBK2.43077977
8EIF2AK32.40913028
9AKT32.34986783
10VRK22.29806337
11MAP3K42.25192455
12TYK22.23739585
13SRPK12.17789901
14KIT2.16904772
15FRK1.82055061
16NUAK11.69424113
17BCKDK1.67695679
18INSRR1.66157439
19TXK1.62740330
20CSNK1G31.60875893
21NEK11.58455145
22CSNK1A1L1.57851887
23SIK31.54978080
24BCR1.54936848
25ZAK1.51050680
26TEC1.50821975
27MKNK21.38431950
28CSF1R1.37885909
29CSNK1G11.37563243
30RPS6KA41.34113537
31DYRK31.32679974
32PINK11.28747311
33IKBKE1.25593807
34CSNK1G21.22513495
35GRK11.21057003
36ADRBK21.18791653
37PAK31.18484726
38BRSK21.17005949
39DAPK11.16708511
40MAP3K61.15129854
41PLK31.11905011
42TLK11.07953341
43CAMKK21.02825780
44VRK10.95701734
45MAP3K120.95472747
46JAK30.94828200
47TESK10.93274519
48WEE10.91769962
49MAPK110.91205643
50PLK20.90105746
51TAOK30.86127833
52MINK10.84703936
53CDK190.76271317
54CAMK2D0.73865776
55ITK0.73622698
56RIPK40.70575522
57EPHA30.68907517
58PASK0.67741903
59CHEK20.65892737
60PRKD30.64842199
61EIF2AK20.64597116
62SGK20.62651062
63MYLK0.59580779
64MKNK10.59162875
65FGR0.57017214
66TESK20.56756498
67SYK0.56140313
68IKBKB0.54418575
69LIMK10.52852721
70PLK10.50610664
71CAMK2G0.50341751
72PHKG20.49196560
73PHKG10.49196560
74CCNB10.48130131
75MAP2K70.47221962
76TNK20.47110160
77MAPKAPK50.47103165
78BMPR1B0.46629876
79MAPKAPK30.44177770
80RPS6KA50.43628055
81MAP4K20.42972194
82STK38L0.42647626
83PRKCE0.41759222
84IGF1R0.41536642
85ABL20.40860462
86PTK2B0.40777809
87LATS10.40715014
88BTK0.39176189
89MARK30.38187628
90MAPK130.37928446
91FGFR40.36635830
92CASK0.36002364
93CSNK1A10.34857733
94ATR0.32092872
95PRKCH0.31887362
96FLT30.31303764
97DYRK20.29382851
98FGFR30.27381555
99PRKCI0.26340214
100ACVR1B0.26133002

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08855866
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.48293733
3Sulfur metabolism_Homo sapiens_hsa009202.62830783
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45171121
5Non-homologous end-joining_Homo sapiens_hsa034502.24982029
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11962020
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08908058
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98311016
9Tryptophan metabolism_Homo sapiens_hsa003801.93675125
10Steroid biosynthesis_Homo sapiens_hsa001001.91085701
11Propanoate metabolism_Homo sapiens_hsa006401.84746045
12Basal transcription factors_Homo sapiens_hsa030221.84506759
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83575826
14Protein export_Homo sapiens_hsa030601.75110030
15Oxidative phosphorylation_Homo sapiens_hsa001901.66639506
16RNA polymerase_Homo sapiens_hsa030201.65194910
17One carbon pool by folate_Homo sapiens_hsa006701.64689259
18Type I diabetes mellitus_Homo sapiens_hsa049401.61329950
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60965854
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59993700
21Asthma_Homo sapiens_hsa053101.57438528
22Peroxisome_Homo sapiens_hsa041461.52446503
23Selenocompound metabolism_Homo sapiens_hsa004501.50880342
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45267716
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.43653483
26Fanconi anemia pathway_Homo sapiens_hsa034601.41596843
27Pyruvate metabolism_Homo sapiens_hsa006201.39294970
28Antigen processing and presentation_Homo sapiens_hsa046121.38066656
29Linoleic acid metabolism_Homo sapiens_hsa005911.36675705
30Parkinsons disease_Homo sapiens_hsa050121.35620196
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33560112
32ABC transporters_Homo sapiens_hsa020101.31091450
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29817095
34Purine metabolism_Homo sapiens_hsa002301.27658123
35Homologous recombination_Homo sapiens_hsa034401.27606643
36Primary immunodeficiency_Homo sapiens_hsa053401.21387675
37Collecting duct acid secretion_Homo sapiens_hsa049661.20888724
38beta-Alanine metabolism_Homo sapiens_hsa004101.20181764
39Autoimmune thyroid disease_Homo sapiens_hsa053201.19943023
40Allograft rejection_Homo sapiens_hsa053301.17078727
41Graft-versus-host disease_Homo sapiens_hsa053321.11175942
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09126644
43Huntingtons disease_Homo sapiens_hsa050161.05790443
44Pyrimidine metabolism_Homo sapiens_hsa002401.05287585
45Fatty acid elongation_Homo sapiens_hsa000621.04568755
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.04491522
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.03255070
48Chemical carcinogenesis_Homo sapiens_hsa052041.01800409
49Ether lipid metabolism_Homo sapiens_hsa005651.01112252
50Butanoate metabolism_Homo sapiens_hsa006501.00961026
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00959091
52Histidine metabolism_Homo sapiens_hsa003400.96808629
53Circadian rhythm_Homo sapiens_hsa047100.95823805
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95235597
55Olfactory transduction_Homo sapiens_hsa047400.92454295
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.89547783
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88979239
58Fat digestion and absorption_Homo sapiens_hsa049750.88860912
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84606199
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.84004755
61Mismatch repair_Homo sapiens_hsa034300.83311199
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.82660199
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81838639
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79696945
65Fatty acid metabolism_Homo sapiens_hsa012120.78735020
66Rheumatoid arthritis_Homo sapiens_hsa053230.77251934
67Herpes simplex infection_Homo sapiens_hsa051680.77138838
68Glycerolipid metabolism_Homo sapiens_hsa005610.77133631
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76306397
70Caffeine metabolism_Homo sapiens_hsa002320.75608121
71RNA degradation_Homo sapiens_hsa030180.73336144
72Regulation of autophagy_Homo sapiens_hsa041400.71703299
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68711825
74Viral myocarditis_Homo sapiens_hsa054160.68483229
75Lysosome_Homo sapiens_hsa041420.68014613
76Glutathione metabolism_Homo sapiens_hsa004800.67772994
77Metabolic pathways_Homo sapiens_hsa011000.66783490
78Alzheimers disease_Homo sapiens_hsa050100.63550960
79Base excision repair_Homo sapiens_hsa034100.62208102
80Other glycan degradation_Homo sapiens_hsa005110.58614670
81Arachidonic acid metabolism_Homo sapiens_hsa005900.57913781
82Arginine and proline metabolism_Homo sapiens_hsa003300.55063051
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53525292
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52100157
85Phototransduction_Homo sapiens_hsa047440.50999672
86Spliceosome_Homo sapiens_hsa030400.49874641
87Nucleotide excision repair_Homo sapiens_hsa034200.46459479
88Fatty acid degradation_Homo sapiens_hsa000710.45177524
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43334851
90Sphingolipid metabolism_Homo sapiens_hsa006000.43247267
91Hematopoietic cell lineage_Homo sapiens_hsa046400.43239490
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41686543
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40714321
94Epstein-Barr virus infection_Homo sapiens_hsa051690.40406643
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.39905106
96Legionellosis_Homo sapiens_hsa051340.39634922
97Staphylococcus aureus infection_Homo sapiens_hsa051500.38579878
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38422867
99Taste transduction_Homo sapiens_hsa047420.38158418
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.36086372

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