FDPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.88409067
2* cholesterol biosynthetic process (GO:0006695)8.87566076
3* sterol biosynthetic process (GO:0016126)7.79042702
4axon ensheathment in central nervous system (GO:0032291)6.48960524
5central nervous system myelination (GO:0022010)6.48960524
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.16656232
7fatty-acyl-CoA biosynthetic process (GO:0046949)5.74814125
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.59356308
9L-phenylalanine catabolic process (GO:0006559)5.59356308
10* isoprenoid biosynthetic process (GO:0008299)5.44320202
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.40953992
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.24506120
13L-phenylalanine metabolic process (GO:0006558)5.24506120
14L-serine metabolic process (GO:0006563)5.16118916
15fatty-acyl-CoA metabolic process (GO:0035337)5.06713492
16thioester biosynthetic process (GO:0035384)5.00035365
17acyl-CoA biosynthetic process (GO:0071616)5.00035365
18long-chain fatty acid biosynthetic process (GO:0042759)4.66916403
19establishment of integrated proviral latency (GO:0075713)4.53779216
20DNA strand elongation involved in DNA replication (GO:0006271)4.53430217
21heme transport (GO:0015886)4.51657407
22acetyl-CoA metabolic process (GO:0006084)4.51354292
23alpha-linolenic acid metabolic process (GO:0036109)4.46188068
24very long-chain fatty acid metabolic process (GO:0000038)4.44065814
25serine family amino acid biosynthetic process (GO:0009070)4.42789857
26glyoxylate metabolic process (GO:0046487)4.40574918
27DNA strand elongation (GO:0022616)4.32907112
28acyl-CoA metabolic process (GO:0006637)4.18758737
29thioester metabolic process (GO:0035383)4.18758737
30* cholesterol metabolic process (GO:0008203)4.18088010
31response to methylmercury (GO:0051597)4.17869297
32telomere maintenance via semi-conservative replication (GO:0032201)4.12729867
33aromatic amino acid family catabolic process (GO:0009074)4.07286026
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05102265
35aldehyde catabolic process (GO:0046185)4.03302002
36* steroid biosynthetic process (GO:0006694)4.02750608
37axon ensheathment (GO:0008366)3.91815840
38ensheathment of neurons (GO:0007272)3.91815840
39* sterol metabolic process (GO:0016125)3.86616361
40coenzyme catabolic process (GO:0009109)3.85680361
41myelination (GO:0042552)3.83088539
42tyrosine metabolic process (GO:0006570)3.77426461
43amyloid precursor protein metabolic process (GO:0042982)3.76758419
44bile acid biosynthetic process (GO:0006699)3.76321786
45DNA unwinding involved in DNA replication (GO:0006268)3.73218393
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69227166
47chromatin remodeling at centromere (GO:0031055)3.68975562
48proteasome assembly (GO:0043248)3.63342828
49establishment of viral latency (GO:0019043)3.62173263
50CENP-A containing nucleosome assembly (GO:0034080)3.59998321
51mitotic sister chromatid segregation (GO:0000070)3.55986590
52* alcohol biosynthetic process (GO:0046165)3.52282974
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50398032
54ATP synthesis coupled proton transport (GO:0015986)3.49474064
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49474064
56cofactor catabolic process (GO:0051187)3.48218594
57iron coordination entity transport (GO:1901678)3.47451654
58response to lipoprotein particle (GO:0055094)3.47052731
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45512072
60ethanol oxidation (GO:0006069)3.45200743
61regulation of mitochondrial translation (GO:0070129)3.42344046
62amyloid precursor protein catabolic process (GO:0042987)3.41339768
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40836123
64negative regulation of ligase activity (GO:0051352)3.40836123
65protein localization to kinetochore (GO:0034501)3.40553564
66telomere maintenance via recombination (GO:0000722)3.37247875
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36910683
68serine family amino acid metabolic process (GO:0009069)3.34855715
69DNA replication checkpoint (GO:0000076)3.34399447
70glycine metabolic process (GO:0006544)3.32441075
71mitotic recombination (GO:0006312)3.32191997
72negative regulation of fibrinolysis (GO:0051918)3.31901855
73triglyceride biosynthetic process (GO:0019432)3.30150868
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.29447968
75coenzyme A metabolic process (GO:0015936)3.29239408
76aromatic amino acid family metabolic process (GO:0009072)3.26781037
77cysteine metabolic process (GO:0006534)3.25913126
78mitotic metaphase plate congression (GO:0007080)3.25125680
79purine nucleobase biosynthetic process (GO:0009113)3.25114959
80establishment of mitochondrion localization (GO:0051654)3.24796306
81myelin maintenance (GO:0043217)3.22964333
82plasma lipoprotein particle clearance (GO:0034381)3.19272496
83regulation of cellular amino acid metabolic process (GO:0006521)3.18884910
84ethanol metabolic process (GO:0006067)3.18126722
85sister chromatid segregation (GO:0000819)3.17929057
86NADPH regeneration (GO:0006740)3.17025910
87acylglycerol biosynthetic process (GO:0046463)3.16870957
88neutral lipid biosynthetic process (GO:0046460)3.16870957
89DNA ligation (GO:0006266)3.16218080
90nucleobase biosynthetic process (GO:0046112)3.16126871
91maturation of SSU-rRNA (GO:0030490)3.11830012
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11341187
93protein neddylation (GO:0045116)3.10841450
94cellular aldehyde metabolic process (GO:0006081)3.08739754
95regulation of cholesterol biosynthetic process (GO:0045540)3.08117729
96sulfur amino acid catabolic process (GO:0000098)3.06162748
97tRNA aminoacylation for protein translation (GO:0006418)3.06057508
98DNA replication-independent nucleosome organization (GO:0034724)3.05895995
99DNA replication-independent nucleosome assembly (GO:0006336)3.05895995
100positive regulation of cellular amine metabolic process (GO:0033240)3.05718378
101regulation of fibrinolysis (GO:0051917)3.04954311
102regulation of lipoprotein metabolic process (GO:0050746)3.03900833
103bile acid metabolic process (GO:0008206)3.03451218
104glutathione derivative biosynthetic process (GO:1901687)3.03332164
105glutathione derivative metabolic process (GO:1901685)3.03332164
106DNA replication initiation (GO:0006270)3.03041946
107formation of translation preinitiation complex (GO:0001731)3.02425132
108nucleotide-excision repair, DNA gap filling (GO:0006297)3.02192878
109tRNA aminoacylation (GO:0043039)3.00994032
110amino acid activation (GO:0043038)3.00994032
111DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00496065
112protein localization to chromosome, centromeric region (GO:0071459)3.00410567
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00113535
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00113535
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00113535
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99880687
117high-density lipoprotein particle remodeling (GO:0034375)2.98932710
118intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98909517
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98909517
120cellular ketone body metabolic process (GO:0046950)2.98557907
121substantia nigra development (GO:0021762)2.98154330
122spliceosomal snRNP assembly (GO:0000387)2.97945873
123IMP biosynthetic process (GO:0006188)2.96375285
124signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96021733
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.96021733
126cullin deneddylation (GO:0010388)2.94684335
127regulation of translational fidelity (GO:0006450)2.93504496
128pyrimidine-containing compound transmembrane transport (GO:0072531)2.93248522
129DNA replication-dependent nucleosome assembly (GO:0006335)2.92799314
130DNA replication-dependent nucleosome organization (GO:0034723)2.92799314
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.92471321
132* organic hydroxy compound biosynthetic process (GO:1901617)2.91570260
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90840786
134regulation of collateral sprouting (GO:0048670)2.90638744
135DNA damage response, detection of DNA damage (GO:0042769)2.90632553
136glycerophospholipid catabolic process (GO:0046475)2.90291879
137histone exchange (GO:0043486)2.89175005
138telomere maintenance via telomere lengthening (GO:0010833)2.86959750
139ketone body metabolic process (GO:1902224)2.86093344
140regulation of cholesterol metabolic process (GO:0090181)2.84945242
141response to phenylpropanoid (GO:0080184)2.82661327
142peptidyl-glutamic acid carboxylation (GO:0017187)2.82296758
143protein carboxylation (GO:0018214)2.82296758
144chaperone-mediated protein transport (GO:0072321)2.82247674
145metaphase plate congression (GO:0051310)2.82083739
146water-soluble vitamin biosynthetic process (GO:0042364)2.82034860
147ribosomal small subunit assembly (GO:0000028)2.81797604
148mitotic chromosome condensation (GO:0007076)2.81640839
149very-low-density lipoprotein particle assembly (GO:0034379)2.81157303
150pyrimidine nucleobase catabolic process (GO:0006208)2.80993116
151kynurenine metabolic process (GO:0070189)2.80306347
152ribosomal large subunit biogenesis (GO:0042273)2.79678873
153oxidative phosphorylation (GO:0006119)2.79259670
154nucleobase-containing small molecule interconversion (GO:0015949)2.78773082
155transcription-coupled nucleotide-excision repair (GO:0006283)2.78272875
156positive regulation of ligase activity (GO:0051351)2.78211641
157amino acid salvage (GO:0043102)2.77750131
158L-methionine salvage (GO:0071267)2.77750131
159L-methionine biosynthetic process (GO:0071265)2.77750131
160kinetochore organization (GO:0051383)2.76790948
161alpha-amino acid biosynthetic process (GO:1901607)2.76333975
162estrogen biosynthetic process (GO:0006703)2.75713535
163DNA strand renaturation (GO:0000733)2.75638544
164regulation of ubiquitin-protein transferase activity (GO:0051438)2.74667944
165respiratory electron transport chain (GO:0022904)2.73722282
166intestinal cholesterol absorption (GO:0030299)2.72515925
167negative regulation of sterol transport (GO:0032372)2.72381984
168negative regulation of cholesterol transport (GO:0032375)2.72381984
169regulation of cholesterol esterification (GO:0010872)2.71666392
170protein deneddylation (GO:0000338)2.71261915
171indolalkylamine catabolic process (GO:0046218)2.71143831
172tryptophan catabolic process (GO:0006569)2.71143831
173indole-containing compound catabolic process (GO:0042436)2.71143831
174cellular response to cholesterol (GO:0071397)2.71116327
175tetrahydrofolate metabolic process (GO:0046653)2.69879905
176pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69399594
177mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68205501
178ribosomal small subunit biogenesis (GO:0042274)2.65427379
179electron transport chain (GO:0022900)2.65099670
180regulation of ligase activity (GO:0051340)2.64683010
181non-recombinational repair (GO:0000726)2.64327025
182double-strand break repair via nonhomologous end joining (GO:0006303)2.64327025
183pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.63895392
184protein targeting to mitochondrion (GO:0006626)2.63233660
185ribosome assembly (GO:0042255)2.62921318
186rRNA modification (GO:0000154)2.61764035
187kinetochore assembly (GO:0051382)2.60435523
188cell cycle G1/S phase transition (GO:0044843)2.58875748
189G1/S transition of mitotic cell cycle (GO:0000082)2.58875748
190base-excision repair (GO:0006284)2.58012146
191mitotic nuclear envelope disassembly (GO:0007077)2.55141819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.29096835
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.63221555
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.10570700
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.77955235
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.98284094
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.72079073
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.63201424
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61551599
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58921127
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48994618
11PPARA_22158963_ChIP-Seq_LIVER_Mouse3.46375859
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40791476
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.31459962
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.28134296
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16611995
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.05081849
17LXR_22158963_ChIP-Seq_LIVER_Mouse3.01579877
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97595187
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.87962229
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59577240
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.57652364
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51983768
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.48767533
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39009850
25* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22224641
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14267626
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11037480
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.06660325
29ZNF263_19887448_ChIP-Seq_K562_Human2.03541130
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95861630
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90851556
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90804995
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90566342
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90470316
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90234063
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.88549697
37CLOCK_20551151_ChIP-Seq_293T_Human1.79403763
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78431164
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73669935
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66523284
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66042658
42* XRN2_22483619_ChIP-Seq_HELA_Human1.61722046
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59989790
44AR_21909140_ChIP-Seq_LNCAP_Human1.54128259
45SOX17_20123909_ChIP-Seq_XEN_Mouse1.51939044
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48782052
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48597350
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.47966252
49HTT_18923047_ChIP-ChIP_STHdh_Human1.46827164
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45776057
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44643452
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44450609
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43807688
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42258556
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40827681
56DCP1A_22483619_ChIP-Seq_HELA_Human1.35510114
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34511165
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30177301
59* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28901412
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28444380
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24986394
62MYC_18940864_ChIP-ChIP_HL60_Human1.24670440
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23475905
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.22635912
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22173811
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19362396
67EOMES_21245162_ChIP-Seq_HESCs_Human1.19102559
68* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18932574
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18391567
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14537304
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14513193
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13786459
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13371282
74* NANOG_16153702_ChIP-ChIP_HESCs_Human1.13019855
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10664365
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10334872
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10172596
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09439279
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08472087
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07951228
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.07072671
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01673279
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01455738
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01239881
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00950197
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00904634
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99859131
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99669523
89TRIM28_21343339_ChIP-Seq_HEK293_Human0.99189904
90GABP_19822575_ChIP-Seq_HepG2_Human0.98685060
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96932682
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96756927
93CTCF_20526341_ChIP-Seq_ESCs_Human0.96559299
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95041195
95* YY1_22570637_ChIP-Seq_MALME-3M_Human0.93177851
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.92381591
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91220088
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91220088
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91220088
100VDR_23849224_ChIP-Seq_CD4+_Human0.90348991
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90158809
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90097857
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89687161
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89207686
105MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88791478
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.88706515
107NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88367349
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88211640
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.88112184
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.87017628
111CIITA_25753668_ChIP-Seq_RAJI_Human0.86940256
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86119356
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85912665
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85095126
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84963763
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84880678
117NCOR_22424771_ChIP-Seq_293T_Human0.83288975
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83134958
119IRF1_19129219_ChIP-ChIP_H3396_Human0.82664644
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79054345
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78888956
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78326183
123* KDM5A_27292631_Chip-Seq_BREAST_Human0.75757052
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75465229
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75461689
126* ELK1_22589737_ChIP-Seq_MCF10A_Human0.74767178
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73361940
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72208737
129TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70153018
130ELK1_19687146_ChIP-ChIP_HELA_Human0.69954940
131* FOXP1_21924763_ChIP-Seq_HESCs_Human0.69453333
132FOXP3_21729870_ChIP-Seq_TREG_Human0.68968847
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68420785
134TTF2_22483619_ChIP-Seq_HELA_Human0.68091091
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.67568022
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.67454876
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65565714
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.65540639
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64919674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.83336407
2MP0003806_abnormal_nucleotide_metabolis5.56214612
3MP0005360_urolithiasis4.37218781
4MP0005085_abnormal_gallbladder_physiolo4.04379470
5MP0010094_abnormal_chromosome_stability3.89329341
6MP0009840_abnormal_foam_cell3.69789948
7MP0003693_abnormal_embryo_hatching3.64599616
8MP0005083_abnormal_biliary_tract3.54036154
9MP0004957_abnormal_blastocyst_morpholog3.29436975
10MP0003111_abnormal_nucleus_morphology3.26647722
11MP0005365_abnormal_bile_salt3.21156785
12MP0000920_abnormal_myelination3.14151512
13MP0008875_abnormal_xenobiotic_pharmacok3.08103581
14MP0008058_abnormal_DNA_repair3.01995591
15MP0001529_abnormal_vocalization2.85538901
16MP0003077_abnormal_cell_cycle2.71662737
17MP0003329_amyloid_beta_deposits2.71258382
18MP0003122_maternal_imprinting2.63977329
19MP0005408_hypopigmentation2.54012379
20MP0003011_delayed_dark_adaptation2.51833435
21MP0003195_calcinosis2.39881192
22MP0005451_abnormal_body_composition2.26542989
23MP0006292_abnormal_olfactory_placode2.20402888
24MP0003941_abnormal_skin_development2.16823685
25MP0000372_irregular_coat_pigmentation2.04700480
26MP0010030_abnormal_orbit_morphology2.04131443
27MP0008007_abnormal_cellular_replicative1.99113408
28MP0000566_synostosis1.92531082
29MP0005332_abnormal_amino_acid1.89433128
30MP0003315_abnormal_perineum_morphology1.87652385
31MP0005394_taste/olfaction_phenotype1.86692931
32MP0005499_abnormal_olfactory_system1.86692931
33MP0010329_abnormal_lipoprotein_level1.84503325
34MP0001905_abnormal_dopamine_level1.84111261
35MP0000604_amyloidosis1.82339177
36MP0003718_maternal_effect1.81393613
37MP0001293_anophthalmia1.75953247
38MP0003121_genomic_imprinting1.74340699
39MP0001666_abnormal_nutrient_absorption1.70488741
40MP0003786_premature_aging1.69653207
41MP0003656_abnormal_erythrocyte_physiolo1.69172460
42MP0003123_paternal_imprinting1.66313431
43MP0004381_abnormal_hair_follicle1.65181634
44MP0003186_abnormal_redox_activity1.63046792
45MP0003950_abnormal_plasma_membrane1.61809898
46MP0002118_abnormal_lipid_homeostasis1.59828312
47MP0000647_abnormal_sebaceous_gland1.56188427
48MP0003690_abnormal_glial_cell1.56152482
49MP0008438_abnormal_cutaneous_collagen1.53172277
50MP0003632_abnormal_nervous_system1.52176471
51MP0001661_extended_life_span1.51522389
52MP0004142_abnormal_muscle_tone1.46959661
53MP0008260_abnormal_autophagy1.46168012
54MP0005171_absent_coat_pigmentation1.40431711
55MP0003252_abnormal_bile_duct1.39129516
56MP0002697_abnormal_eye_size1.37593807
57MP0003634_abnormal_glial_cell1.36888675
58MP0002796_impaired_skin_barrier1.34390281
59MP0002233_abnormal_nose_morphology1.33127859
60MP0004270_analgesia1.32109175
61MP0000350_abnormal_cell_proliferation1.30568875
62MP0009379_abnormal_foot_pigmentation1.29543642
63MP0000462_abnormal_digestive_system1.24277053
64MP0003567_abnormal_fetal_cardiomyocyte1.22973742
65MP0005380_embryogenesis_phenotype1.22935488
66MP0001672_abnormal_embryogenesis/_devel1.22935488
67MP0001697_abnormal_embryo_size1.21037472
68MP0003136_yellow_coat_color1.20708892
69MP0001286_abnormal_eye_development1.19228676
70MP0002085_abnormal_embryonic_tissue1.18701659
71MP0002080_prenatal_lethality1.18219147
72MP0000358_abnormal_cell_content/1.14711293
73MP0000778_abnormal_nervous_system1.10567692
74MP0000609_abnormal_liver_physiology1.09988127
75MP0003984_embryonic_growth_retardation1.07100392
76MP0010678_abnormal_skin_adnexa1.05792904
77MP0002084_abnormal_developmental_patter1.05642766
78MP0002822_catalepsy1.05110885
79MP0002111_abnormal_tail_morphology1.05027253
80MP0005584_abnormal_enzyme/coenzyme_acti1.04167669
81MP0002088_abnormal_embryonic_growth/wei1.02862981
82MP0003755_abnormal_palate_morphology1.00692273
83MP0008932_abnormal_embryonic_tissue0.99258730
84MP0000537_abnormal_urethra_morphology0.98939202
85MP0000049_abnormal_middle_ear0.97225149
86MP0004147_increased_porphyrin_level0.96706071
87MP0004272_abnormal_basement_membrane0.96511935
88MP0002938_white_spotting0.96171567
89MP0004019_abnormal_vitamin_homeostasis0.94947176
90MP0005501_abnormal_skin_physiology0.94827009
91MP0004197_abnormal_fetal_growth/weight/0.92149960
92MP0002092_abnormal_eye_morphology0.91135825
93MP0004885_abnormal_endolymph0.89469576
94MP0005410_abnormal_fertilization0.89025167
95MP0008057_abnormal_DNA_replication0.88849096
96MP0002234_abnormal_pharynx_morphology0.88618411
97MP0001764_abnormal_homeostasis0.88341823
98MP0005084_abnormal_gallbladder_morpholo0.87610543
99MP0000383_abnormal_hair_follicle0.87598158
100MP0003119_abnormal_digestive_system0.87552662
101MP0003942_abnormal_urinary_system0.87136556
102MP0002210_abnormal_sex_determination0.86803645
103MP0003868_abnormal_feces_composition0.86751700
104MP0002163_abnormal_gland_morphology0.86556710
105MP0002229_neurodegeneration0.85469677
106MP0004742_abnormal_vestibular_system0.85280254
107MP0003385_abnormal_body_wall0.84408393
108MP0003191_abnormal_cellular_cholesterol0.83014817
109MP0001243_abnormal_dermal_layer0.82965523
110MP0006072_abnormal_retinal_apoptosis0.81705892
111MP0000579_abnormal_nail_morphology0.81454676
112MP0001984_abnormal_olfaction0.81136451
113MP0009053_abnormal_anal_canal0.79496707
114MP0004134_abnormal_chest_morphology0.78961717
115MP0003937_abnormal_limbs/digits/tail_de0.78497568
116MP0003861_abnormal_nervous_system0.78020034
117MP0005395_other_phenotype0.77362646
118MP0000313_abnormal_cell_death0.77070513
119MP0000762_abnormal_tongue_morphology0.76904028
120MP0001340_abnormal_eyelid_morphology0.76249813
121MP0004185_abnormal_adipocyte_glucose0.76051260
122MP0005391_vision/eye_phenotype0.75961603
123MP0002282_abnormal_trachea_morphology0.75843058
124MP0002295_abnormal_pulmonary_circulatio0.75458934
125MP0000467_abnormal_esophagus_morphology0.74809558
126MP0000747_muscle_weakness0.74500046
127MP0001542_abnormal_bone_strength0.74266546
128MP0003631_nervous_system_phenotype0.73103299
129MP0005319_abnormal_enzyme/_coenzyme0.71365915
130MP0001929_abnormal_gametogenesis0.70020852
131MP0009672_abnormal_birth_weight0.69896923
132MP0005058_abnormal_lysosome_morphology0.69318460
133MP0005187_abnormal_penis_morphology0.69230196
134MP0009697_abnormal_copulation0.69172216
135MP0001145_abnormal_male_reproductive0.68890084
136MP0002751_abnormal_autonomic_nervous0.68055323
137MP0004133_heterotaxia0.67962650
138MP0006036_abnormal_mitochondrial_physio0.67441579
139MP0002102_abnormal_ear_morphology0.66925614
140MP0000639_abnormal_adrenal_gland0.66819702
141MP0001727_abnormal_embryo_implantation0.66272134
142MP0009765_abnormal_xenobiotic_induced0.66227362
143MP0008873_increased_physiological_sensi0.66055921
144MP0006035_abnormal_mitochondrial_morpho0.65973413
145MP0001485_abnormal_pinna_reflex0.65764497
146MP0002733_abnormal_thermal_nociception0.64099198
147MP0009703_decreased_birth_body0.63447511
148MP0002086_abnormal_extraembryonic_tissu0.63019080
149MP0000653_abnormal_sex_gland0.62625491
150MP0006276_abnormal_autonomic_nervous0.62495164
151MP0005248_abnormal_Harderian_gland0.61704476
152MP0000955_abnormal_spinal_cord0.60967642
153MP0008789_abnormal_olfactory_epithelium0.60902306
154MP0000377_abnormal_hair_follicle0.60779923
155MP0001346_abnormal_lacrimal_gland0.59945767
156MP0002734_abnormal_mechanical_nocicepti0.59422250
157MP0003890_abnormal_embryonic-extraembry0.56452568
158MP0000598_abnormal_liver_morphology0.56094237
159MP0005275_abnormal_skin_tensile0.55549403
160MP0005195_abnormal_posterior_eye0.55188085
161MP0009643_abnormal_urine_homeostasis0.55093721
162MP0001730_embryonic_growth_arrest0.55014786
163MP0000538_abnormal_urinary_bladder0.54236634
164MP0010771_integument_phenotype0.54089739

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)6.29856408
2Increased serum pyruvate (HP:0003542)6.29856408
3Parakeratosis (HP:0001036)5.29930355
4Intrahepatic cholestasis (HP:0001406)4.97383908
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.93909172
6Neurofibrillary tangles (HP:0002185)4.47664251
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.24297586
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.24297586
9Hypobetalipoproteinemia (HP:0003563)4.23702632
10Xanthomatosis (HP:0000991)4.18682946
11Deep venous thrombosis (HP:0002625)4.16441252
12Cerebral hypomyelination (HP:0006808)4.00813143
13Congenital ichthyosiform erythroderma (HP:0007431)3.77399841
14Cerebral inclusion bodies (HP:0100314)3.62294230
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60777850
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57737663
17Abnormality of the corticospinal tract (HP:0002492)3.57312109
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54520496
19Hypoplastic pelvis (HP:0008839)3.37427338
20Chromsome breakage (HP:0040012)3.23988887
21Spastic paraparesis (HP:0002313)3.19840820
22Abnormality of methionine metabolism (HP:0010901)3.14285822
23Prolonged partial thromboplastin time (HP:0003645)3.08598598
24Hyperlipoproteinemia (HP:0010980)3.07085388
25Reticulocytopenia (HP:0001896)3.04521396
26Sensory axonal neuropathy (HP:0003390)3.04118473
27Leukodystrophy (HP:0002415)2.98436027
28Epidermoid cyst (HP:0200040)2.96657197
29Meckel diverticulum (HP:0002245)2.90070607
30Microvesicular hepatic steatosis (HP:0001414)2.87449760
31Cortical dysplasia (HP:0002539)2.86692642
32Insidious onset (HP:0003587)2.83177720
33Termporal pattern (HP:0011008)2.83177720
34Abnormality of the ileum (HP:0001549)2.76222755
35Increased CSF lactate (HP:0002490)2.72589914
36Abnormal lung lobation (HP:0002101)2.71500833
37Progressive macrocephaly (HP:0004481)2.71057635
38Hyperglycinemia (HP:0002154)2.68980462
39Abnormal gallbladder physiology (HP:0012438)2.67710394
40Cholecystitis (HP:0001082)2.67710394
41Abnormality of glycine metabolism (HP:0010895)2.67034481
42Abnormality of serine family amino acid metabolism (HP:0010894)2.67034481
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62243894
44Abnormality of the labia minora (HP:0012880)2.58461856
45Increased hepatocellular lipid droplets (HP:0006565)2.56343353
46Colon cancer (HP:0003003)2.55276848
47Abnormality of the preputium (HP:0100587)2.54801423
48Fat malabsorption (HP:0002630)2.53935224
49Overlapping toe (HP:0001845)2.53430762
50Cerebral edema (HP:0002181)2.52081320
51Amniotic constriction ring (HP:0009775)2.51273735
52Abnormality of placental membranes (HP:0011409)2.51273735
53Hypolipoproteinemia (HP:0010981)2.50298052
54Peripheral hypomyelination (HP:0007182)2.49493011
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.48875141
56Autoamputation (HP:0001218)2.47836913
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.46476621
58CNS hypomyelination (HP:0003429)2.45697148
59Lipid accumulation in hepatocytes (HP:0006561)2.44453293
60Septate vagina (HP:0001153)2.39526015
61Increased nuchal translucency (HP:0010880)2.37589802
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34832299
63Horseshoe kidney (HP:0000085)2.34610710
64Acute encephalopathy (HP:0006846)2.33432228
65Steatorrhea (HP:0002570)2.30668096
66Increased serum lactate (HP:0002151)2.28316236
67Hyperammonemia (HP:0001987)2.27096791
68Epiphyseal stippling (HP:0010655)2.24560626
69Stridor (HP:0010307)2.18366814
70Acute necrotizing encephalopathy (HP:0006965)2.18211918
71Methylmalonic acidemia (HP:0002912)2.14923272
72Bifid tongue (HP:0010297)2.14420671
73Spastic gait (HP:0002064)2.13795487
74Hypophosphatemic rickets (HP:0004912)2.13779702
75Brushfield spots (HP:0001088)2.11825526
76Morphological abnormality of the pyramidal tract (HP:0002062)2.09529160
77Abnormal gallbladder morphology (HP:0012437)2.09452051
78Abnormality of chromosome stability (HP:0003220)2.08246197
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07973092
80Lactic acidosis (HP:0003128)2.07087779
81Poor suck (HP:0002033)2.05948787
82Small intestinal stenosis (HP:0012848)2.05838019
83Duodenal stenosis (HP:0100867)2.05838019
84Irritability (HP:0000737)2.04520599
85Erythroderma (HP:0001019)2.03223415
86Paraparesis (HP:0002385)2.02970561
87Facial hemangioma (HP:0000329)2.02101439
88Segmental peripheral demyelination/remyelination (HP:0003481)2.00827391
89Macrocytic anemia (HP:0001972)2.00415143
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00276550
91Onion bulb formation (HP:0003383)2.00235717
92Generalized hypotonia (HP:0001290)1.98991902
93Myelomeningocele (HP:0002475)1.98984489
94Abnormality of cells of the erythroid lineage (HP:0012130)1.98583070
95Hepatosplenomegaly (HP:0001433)1.98442563
96Lethargy (HP:0001254)1.98377308
97Hyperglycinuria (HP:0003108)1.94005484
98Complement deficiency (HP:0004431)1.93945607
99Abnormality of serum amino acid levels (HP:0003112)1.93295535
100Birth length less than 3rd percentile (HP:0003561)1.91929785
101Prolonged neonatal jaundice (HP:0006579)1.91402134
102Renal Fanconi syndrome (HP:0001994)1.91236358
103Supranuclear gaze palsy (HP:0000605)1.91064061
104Exercise intolerance (HP:0003546)1.90542518
105Abnormality of the duodenum (HP:0002246)1.90415791
106Opisthotonus (HP:0002179)1.90344315
107Partial agenesis of the corpus callosum (HP:0001338)1.90006528
108Broad alveolar ridges (HP:0000187)1.89446281
109Acanthocytosis (HP:0001927)1.88721282
110Delusions (HP:0000746)1.88588634
111Reduced antithrombin III activity (HP:0001976)1.87897273
112Secondary amenorrhea (HP:0000869)1.87033618
113Abnormalities of placenta or umbilical cord (HP:0001194)1.86934547
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85841016
115Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85841016
116Abnormality of the carotid arteries (HP:0005344)1.85513042
117Microglossia (HP:0000171)1.85484314
118External ophthalmoplegia (HP:0000544)1.85295570
119Abnormal number of erythroid precursors (HP:0012131)1.85213736
120Abnormal epiphyseal ossification (HP:0010656)1.84554287
121Adrenal hypoplasia (HP:0000835)1.83144903
122Cerebral hemorrhage (HP:0001342)1.82609512
123Hemivertebrae (HP:0002937)1.82208726
124Delayed myelination (HP:0012448)1.81673125
125Skin nodule (HP:0200036)1.81590701
126Abnormal cartilage morphology (HP:0002763)1.81515033
127Akinesia (HP:0002304)1.81450417
128Ileus (HP:0002595)1.81092361
129Abnormality of the gallbladder (HP:0005264)1.79120866
130Abnormality of the common coagulation pathway (HP:0010990)1.78907618
131Hepatocellular necrosis (HP:0001404)1.78502340
132Proximal placement of thumb (HP:0009623)1.78379710
133Abnormal mitochondria in muscle tissue (HP:0008316)1.78004362
134Abnormality of pyrimidine metabolism (HP:0004353)1.77100414
135Type I transferrin isoform profile (HP:0003642)1.77024768
136Abnormality of fatty-acid metabolism (HP:0004359)1.75779428
137Ketosis (HP:0001946)1.75108841
138Multiple enchondromatosis (HP:0005701)1.75002102
139Hepatic necrosis (HP:0002605)1.74922738
140Delayed CNS myelination (HP:0002188)1.74051168
141Abnormality of the metopic suture (HP:0005556)1.72622116
142Absent epiphyses (HP:0010577)1.72310167
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72310167
144Mitochondrial inheritance (HP:0001427)1.71496249
145Postnatal microcephaly (HP:0005484)1.71317456
146Abnormal autonomic nervous system physiology (HP:0012332)1.71076690
147Peritonitis (HP:0002586)1.70981407
148Prominent metopic ridge (HP:0005487)1.69933914
149Pancytopenia (HP:0001876)1.69573767
150Pheochromocytoma (HP:0002666)1.68905916
151Respiratory failure (HP:0002878)1.68435181
152Stenosis of the external auditory canal (HP:0000402)1.68224398
153Sparse eyelashes (HP:0000653)1.68216795
154Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64611982
155Increased intramyocellular lipid droplets (HP:0012240)1.64585505
156Triphalangeal thumb (HP:0001199)1.64179681
157Sloping forehead (HP:0000340)1.63069387
158Ependymoma (HP:0002888)1.62980911
159Hypoglycemic coma (HP:0001325)1.62901181
160Deviation of the thumb (HP:0009603)1.61673337
161Absent thumb (HP:0009777)1.60269396
162Squamous cell carcinoma (HP:0002860)1.59608502
163Hypoplastic female external genitalia (HP:0012815)1.59588044
164Nephroblastoma (Wilms tumor) (HP:0002667)1.58827730
165Spastic diplegia (HP:0001264)1.58214474
166Pterygium (HP:0001059)1.57372510
167Facial cleft (HP:0002006)1.56336796
168Abnormality of reticulocytes (HP:0004312)1.55658664
169Neoplasm of the adrenal gland (HP:0100631)1.53361537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.98311988
2TESK24.22722574
3VRK23.91802525
4PBK3.86821229
5NEK13.69584800
6EPHB13.52989248
7CDC73.52772727
8LIMK13.48246397
9BUB13.08679367
10MET2.70759418
11BCR2.55131765
12OXSR12.55112653
13CSNK1G32.38520426
14ZAK2.27206273
15DYRK22.18670861
16TESK12.11977727
17NTRK11.98267123
18MAPKAPK51.95726080
19PKN11.92963097
20WNK41.85232258
21CSNK1A1L1.81698833
22CSNK1G11.77545667
23PNCK1.72514766
24UHMK11.68917246
25MST41.66030133
26TRIM281.63547169
27PLK11.62373392
28CSNK1G21.58711947
29FGFR21.58025233
30MARK11.54698948
31STK161.52008369
32BCKDK1.49082113
33ERBB41.40504924
34EIF2AK11.34379203
35BRSK11.33919246
36ARAF1.30901254
37TAF11.30018414
38AURKB1.28650151
39ATR1.25029375
40CHEK21.24131877
41NEK21.21646846
42CDK191.21022921
43EPHA21.19066907
44MST1R1.17161065
45NUAK11.14664404
46NME21.14229235
47BRSK21.13267427
48CDK141.10248937
49PDK21.09619273
50CCNB11.07957930
51PAK41.07842094
52CDK81.03094923
53EPHB21.01471520
54ABL21.00893204
55MKNK21.00428631
56EIF2AK30.99325165
57MAP2K20.99252648
58CDK150.98597967
59MAP2K70.98264922
60PAK10.96648115
61ROCK20.96286016
62CDK70.95934836
63KDR0.95821850
64CDK180.92668093
65FGR0.90508431
66CAMK2B0.89676920
67CDK11A0.89413336
68CHEK10.89324527
69SMG10.88283987
70AURKA0.87393181
71WEE10.86043881
72WNK30.85247714
73TSSK60.83530692
74ICK0.81907399
75MAP3K120.78121809
76MKNK10.77794282
77TYRO30.74338284
78EIF2AK20.72025104
79ATM0.71433622
80FLT30.70004144
81CAMK2G0.69928801
82PAK30.69357456
83ILK0.67812208
84PLK20.67722409
85IRAK20.67633656
86RPS6KA40.66672376
87LRRK20.66622499
88TIE10.65321050
89GSK3A0.65050363
90TLK10.63493183
91CSNK2A10.62269311
92MAP3K80.61996874
93MINK10.60584118
94CSNK1E0.59596884
95CAMK2D0.59541940
96TNIK0.58469581
97ALK0.58060559
98DAPK10.55954971
99CDK10.55903608
100MAP4K20.55027740
101SIK10.54206012
102DYRK30.54090943
103BMPR1B0.54089809
104RPS6KA50.53675770
105ERBB20.51271687
106SGK2230.50625491
107SGK4940.50625491
108CLK10.49704521
109PLK40.49469803
110STK40.48866695
111PAK60.48819017
112BLK0.47661920
113AKT20.47127347
114MAP3K20.47030901
115CDK20.46992279
116KSR20.45050462
117FGFR40.44705237
118CSNK1D0.44281156
119MAPK40.43867444
120RPS6KB20.43761827
121PAK20.43598459
122CSNK2A20.42744445
123NME10.41694376
124PIM20.40214334
125PRKDC0.40195965
126PLK30.39401430
127FGFR10.39306290
128SRPK10.39202525
129BMX0.37485006
130PTK20.37097738
131PRKD30.36714288
132TGFBR10.36199709
133MAP2K10.35900493
134DDR20.35553910
135WNK10.34982726
136PRKCQ0.34066981
137BRAF0.33930992
138PRKCI0.33516617
139VRK10.33354805
140PASK0.33326864
141LATS20.32130163
142DAPK30.31731215
143PRKACB0.30934203
144PHKG20.30188768
145PHKG10.30188768
146GRK50.29190993
147TTK0.28369787
148IRAK10.28253423
149CSNK1A10.27967461

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001005.55139617
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.91120368
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.17483452
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.53923669
5Fatty acid elongation_Homo sapiens_hsa000623.45308628
6DNA replication_Homo sapiens_hsa030303.24575759
7Mismatch repair_Homo sapiens_hsa034302.74549488
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61175781
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.44798421
10Butanoate metabolism_Homo sapiens_hsa006502.40905904
11Proteasome_Homo sapiens_hsa030502.23330322
12Base excision repair_Homo sapiens_hsa034102.09837002
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08347125
14Histidine metabolism_Homo sapiens_hsa003402.00682928
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97067686
16Fatty acid metabolism_Homo sapiens_hsa012121.90635648
17Homologous recombination_Homo sapiens_hsa034401.86205636
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82709769
19Vitamin B6 metabolism_Homo sapiens_hsa007501.68545214
20Tryptophan metabolism_Homo sapiens_hsa003801.68079332
21Sulfur metabolism_Homo sapiens_hsa009201.66263448
22Non-homologous end-joining_Homo sapiens_hsa034501.65201083
23Nitrogen metabolism_Homo sapiens_hsa009101.63460874
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62769914
25Propanoate metabolism_Homo sapiens_hsa006401.61074157
26Fanconi anemia pathway_Homo sapiens_hsa034601.58592289
27Peroxisome_Homo sapiens_hsa041461.57317514
28Tyrosine metabolism_Homo sapiens_hsa003501.56413603
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52494717
30Fatty acid degradation_Homo sapiens_hsa000711.50673824
31Pyruvate metabolism_Homo sapiens_hsa006201.49058748
32Glutathione metabolism_Homo sapiens_hsa004801.44457800
33Chemical carcinogenesis_Homo sapiens_hsa052041.42889758
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.37233539
35Phenylalanine metabolism_Homo sapiens_hsa003601.35876616
36Cell cycle_Homo sapiens_hsa041101.30689312
37Folate biosynthesis_Homo sapiens_hsa007901.26798310
38Arginine biosynthesis_Homo sapiens_hsa002201.24110893
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22281684
40Oxidative phosphorylation_Homo sapiens_hsa001901.21595241
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20599673
42Retinol metabolism_Homo sapiens_hsa008301.20589538
43Arginine and proline metabolism_Homo sapiens_hsa003301.19720803
44Ether lipid metabolism_Homo sapiens_hsa005651.18183885
45Complement and coagulation cascades_Homo sapiens_hsa046101.13264580
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08290595
47Biosynthesis of amino acids_Homo sapiens_hsa012301.07457016
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.07315182
49Protein export_Homo sapiens_hsa030601.06015741
50Fat digestion and absorption_Homo sapiens_hsa049751.01488490
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.00744265
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99022131
53Carbon metabolism_Homo sapiens_hsa012000.97898290
54beta-Alanine metabolism_Homo sapiens_hsa004100.97645782
55Parkinsons disease_Homo sapiens_hsa050120.97407590
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95837914
57Linoleic acid metabolism_Homo sapiens_hsa005910.95268613
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.94577598
59RNA degradation_Homo sapiens_hsa030180.94214477
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92572445
61PPAR signaling pathway_Homo sapiens_hsa033200.90158615
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89922685
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89754095
64Ribosome_Homo sapiens_hsa030100.85650483
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85096144
66Sulfur relay system_Homo sapiens_hsa041220.84858413
67RNA polymerase_Homo sapiens_hsa030200.84830866
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83744759
69Purine metabolism_Homo sapiens_hsa002300.81551896
70Basal transcription factors_Homo sapiens_hsa030220.80905283
71Selenocompound metabolism_Homo sapiens_hsa004500.80186086
72One carbon pool by folate_Homo sapiens_hsa006700.75950698
73Pentose phosphate pathway_Homo sapiens_hsa000300.73528722
74* Metabolic pathways_Homo sapiens_hsa011000.70817754
75Fatty acid biosynthesis_Homo sapiens_hsa000610.70241773
76mRNA surveillance pathway_Homo sapiens_hsa030150.69946443
77Alzheimers disease_Homo sapiens_hsa050100.61846718
78N-Glycan biosynthesis_Homo sapiens_hsa005100.60303629
79Vitamin digestion and absorption_Homo sapiens_hsa049770.59734653
80Bile secretion_Homo sapiens_hsa049760.59713140
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55914478
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52913087
83Cardiac muscle contraction_Homo sapiens_hsa042600.50790879
84Huntingtons disease_Homo sapiens_hsa050160.49999364
85Galactose metabolism_Homo sapiens_hsa000520.49692984
86Caffeine metabolism_Homo sapiens_hsa002320.46378887
87p53 signaling pathway_Homo sapiens_hsa041150.45548304
88Sphingolipid metabolism_Homo sapiens_hsa006000.43513389
89Lysine degradation_Homo sapiens_hsa003100.41127792
90Staphylococcus aureus infection_Homo sapiens_hsa051500.39886068
91Oocyte meiosis_Homo sapiens_hsa041140.38569433
92Pyrimidine metabolism_Homo sapiens_hsa002400.37632438
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.35954797
94Basal cell carcinoma_Homo sapiens_hsa052170.35783274
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31568549
96Arachidonic acid metabolism_Homo sapiens_hsa005900.31163670
97Glycerolipid metabolism_Homo sapiens_hsa005610.30721409
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30698227
99ABC transporters_Homo sapiens_hsa020100.30391071
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29805813
101Prion diseases_Homo sapiens_hsa050200.28013685
102Alcoholism_Homo sapiens_hsa050340.27617254
103Axon guidance_Homo sapiens_hsa043600.26851454
104Starch and sucrose metabolism_Homo sapiens_hsa005000.26671574
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.24563413
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.22956727
107Hippo signaling pathway_Homo sapiens_hsa043900.19268714
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15007499
109Vibrio cholerae infection_Homo sapiens_hsa051100.14574336
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14494195
111Spliceosome_Homo sapiens_hsa030400.13962008
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13960139
113Phagosome_Homo sapiens_hsa041450.12286893
114Ovarian steroidogenesis_Homo sapiens_hsa049130.12137379
115Tight junction_Homo sapiens_hsa045300.11913711
116Regulation of autophagy_Homo sapiens_hsa041400.08901744
117Systemic lupus erythematosus_Homo sapiens_hsa053220.07094880
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06930009
119RNA transport_Homo sapiens_hsa030130.06481447
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05857537
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04950056
122Nucleotide excision repair_Homo sapiens_hsa034200.03157962
123Fructose and mannose metabolism_Homo sapiens_hsa000510.02098686

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