FCRLB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucocorticoid metabolic process (GO:0031943)8.52102976
2sodium ion export (GO:0071436)8.40424650
3cellular potassium ion homeostasis (GO:0030007)7.53458123
4snRNA transcription (GO:0009301)7.48287673
5negative regulation of hormone biosynthetic process (GO:0032353)7.31161575
6membrane repolarization during cardiac muscle cell action potential (GO:0086013)7.23336856
7B cell receptor signaling pathway (GO:0050853)7.12354276
8positive regulation of B cell differentiation (GO:0045579)6.79031392
9membrane repolarization during action potential (GO:0086011)6.44425096
10negative regulation of hormone metabolic process (GO:0032351)6.34045806
11negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 6.30059128
12positive regulation of gamma-delta T cell activation (GO:0046645)5.65326039
13regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.37934898
14positive thymic T cell selection (GO:0045059)5.27179486
15germinal center formation (GO:0002467)5.14249186
16auditory receptor cell differentiation (GO:0042491)5.12148706
17negative regulation of heart contraction (GO:0045822)5.02033013
18regulation of B cell differentiation (GO:0045577)4.95420306
19activation of MAPKKK activity (GO:0000185)4.88830963
20negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.88107137
21regulation of cardiac muscle cell contraction (GO:0086004)4.75932743
22type I interferon signaling pathway (GO:0060337)4.75589005
23cellular response to type I interferon (GO:0071357)4.75589005
24regulation of steroid hormone biosynthetic process (GO:0090030)4.75188100
25response to type I interferon (GO:0034340)4.71416763
26relaxation of cardiac muscle (GO:0055119)4.42067850
27regulation of gamma-delta T cell differentiation (GO:0045586)4.41280285
28regulation of macrophage cytokine production (GO:0010935)4.40229518
29diterpenoid biosynthetic process (GO:0016102)4.39047314
30neutrophil activation involved in immune response (GO:0002283)4.37754977
31negative regulation of osteoblast proliferation (GO:0033689)4.30226029
32regulation of germinal center formation (GO:0002634)4.25777363
33folic acid-containing compound biosynthetic process (GO:0009396)4.23899361
34positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.21337277
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19592502
36positive regulation of mast cell degranulation (GO:0043306)4.03271792
37positive regulation of mast cell activation involved in immune response (GO:0033008)4.03271792
38regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.01243089
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98613643
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.98613643
41modulation by symbiont of host immune response (GO:0052553)3.98613643
42positive regulation by symbiont of host defense response (GO:0052509)3.98613643
43modulation by symbiont of host defense response (GO:0052031)3.98613643
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98613643
45I-kappaB phosphorylation (GO:0007252)3.98014825
46positive regulation of DNA-templated transcription, elongation (GO:0032786)3.97178700
47membrane repolarization (GO:0086009)3.92638976
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.92403697
49response to interferon-alpha (GO:0035455)3.89042633
50potassium ion homeostasis (GO:0055075)3.88903301
51positive T cell selection (GO:0043368)3.88871884
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80365367
53fat-soluble vitamin biosynthetic process (GO:0042362)3.80014168
54potassium ion import (GO:0010107)3.78072093
55antigen processing and presentation of endogenous antigen (GO:0019883)3.76123122
56negative regulation of viral genome replication (GO:0045071)3.73868669
57cellular sodium ion homeostasis (GO:0006883)3.71345696
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70105218
59B cell homeostasis (GO:0001782)3.67929815
60regulation of gamma-delta T cell activation (GO:0046643)3.66911781
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64198474
62regulation of histone H3-K27 methylation (GO:0061085)3.61688673
63glycoprotein catabolic process (GO:0006516)3.60662617
64negative regulation of type 2 immune response (GO:0002829)3.57292110
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57175959
66positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.57074198
67positive regulation of mast cell activation (GO:0033005)3.56239825
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.54886193
69regulation of actin filament-based movement (GO:1903115)3.52466444
70positive regulation of cellular amide metabolic process (GO:0034250)3.51863684
71positive regulation of B cell proliferation (GO:0030890)3.50527024
72regulation of protein heterodimerization activity (GO:0043497)3.50270135
73negative regulation of blood circulation (GO:1903523)3.48069491
74positive regulation of toll-like receptor signaling pathway (GO:0034123)3.45929635
75positive regulation of macrophage cytokine production (GO:0060907)3.44788526
76B cell proliferation (GO:0042100)3.44430755
77negative regulation of interleukin-17 production (GO:0032700)3.44007496
78negative regulation of B cell apoptotic process (GO:0002903)3.42618057
79positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40592792
80positive regulation of leukocyte degranulation (GO:0043302)3.40523912
81granulocyte activation (GO:0036230)3.40501867
82macrophage activation involved in immune response (GO:0002281)3.40443536
83positive regulation of B cell activation (GO:0050871)3.40081641
84regulation of alkaline phosphatase activity (GO:0010692)3.40017725
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39795908
86regulation of hormone biosynthetic process (GO:0046885)3.36811470
87cell communication by electrical coupling (GO:0010644)3.36491388
88regulation of lymphocyte chemotaxis (GO:1901623)3.34983280
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.32812306
90serotonin receptor signaling pathway (GO:0007210)3.31502549
91negative regulation of steroid biosynthetic process (GO:0010894)3.27993144
92positive regulation of systemic arterial blood pressure (GO:0003084)3.25580630
93regulation of interferon-beta biosynthetic process (GO:0045357)3.25132410
94glial cell migration (GO:0008347)3.23118370
95regulation of B cell apoptotic process (GO:0002902)3.20727599
96regulation of viral genome replication (GO:0045069)3.19489490
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16238606
98oligosaccharide catabolic process (GO:0009313)3.15067581
99cellular response to arsenic-containing substance (GO:0071243)3.13534716
100eosinophil chemotaxis (GO:0048245)3.13172939
101cell adhesion mediated by integrin (GO:0033627)3.12826775
102response to peptidoglycan (GO:0032494)3.12588841
103negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.12291029
104collagen catabolic process (GO:0030574)3.11268409
105positive regulation of bone resorption (GO:0045780)3.09302332
106positive regulation of bone remodeling (GO:0046852)3.09302332
107G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08403033
108lipopolysaccharide biosynthetic process (GO:0009103)3.08358634
109negative regulation of signal transduction by p53 class mediator (GO:1901797)3.06397352
110regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05757406
111lipopolysaccharide metabolic process (GO:0008653)3.05602143
112activation of JUN kinase activity (GO:0007257)3.05083605
113inner ear receptor cell differentiation (GO:0060113)3.04194989
114negative regulation of myeloid cell apoptotic process (GO:0033033)3.03986430
115neutrophil activation (GO:0042119)3.03797877
116pentose metabolic process (GO:0019321)3.03349722
117sensory perception of sound (GO:0007605)3.02604002
118hair cell differentiation (GO:0035315)3.02496466
119collagen metabolic process (GO:0032963)3.01166048
120negative regulation of cytokine production involved in immune response (GO:0002719)2.97378262
121hydrogen peroxide biosynthetic process (GO:0050665)2.96758177
122sensory perception of mechanical stimulus (GO:0050954)2.96286176
123negative regulation of B cell mediated immunity (GO:0002713)2.95945360
124negative regulation of immunoglobulin mediated immune response (GO:0002890)2.95945360
125cellular response to ethanol (GO:0071361)2.95283991
126thymic T cell selection (GO:0045061)2.95135353
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92528800
128opioid receptor signaling pathway (GO:0038003)2.91719571
129regulation of B cell proliferation (GO:0030888)2.91591918
130respiratory burst (GO:0045730)2.90619903
131eosinophil migration (GO:0072677)2.90511600
132cell aggregation (GO:0098743)2.89156883
133cartilage condensation (GO:0001502)2.89156883
134mucosal-associated lymphoid tissue development (GO:0048537)2.87548227
135Peyers patch development (GO:0048541)2.87548227
136production of molecular mediator involved in inflammatory response (GO:0002532)2.87533887
137negative regulation of steroid metabolic process (GO:0045939)2.86544912
138oocyte development (GO:0048599)2.85375341
139T cell selection (GO:0045058)2.84916318
140myeloid dendritic cell differentiation (GO:0043011)2.82899950
141regulation of mononuclear cell migration (GO:0071675)2.82701029
142positive regulation of chemokine biosynthetic process (GO:0045080)2.81744914
143multicellular organismal catabolic process (GO:0044243)2.80938196
144regulation of superoxide anion generation (GO:0032928)2.80759079
145negative regulation of T cell differentiation (GO:0045581)2.80486064
146positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80073966
147endocytic recycling (GO:0032456)2.79010438
148leukocyte aggregation (GO:0070486)2.78492564
149regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78430612
150regulation of cardioblast proliferation (GO:0003264)2.78430612
151multicellular organismal macromolecule metabolic process (GO:0044259)2.77973330
152regulation of interferon-beta production (GO:0032648)2.77725739
153somatic hypermutation of immunoglobulin genes (GO:0016446)2.76906608
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76906608
155immunoglobulin mediated immune response (GO:0016064)2.75830251
156T cell lineage commitment (GO:0002360)2.75444526
157glycosphingolipid catabolic process (GO:0046479)2.74411578
158positive regulation of interferon-alpha production (GO:0032727)2.72723133
159righting reflex (GO:0060013)2.69218156
160growth hormone receptor signaling pathway (GO:0060396)2.68844251
161regulation of mast cell degranulation (GO:0043304)2.68808020
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68460985
163positive regulation of monocyte chemotaxis (GO:0090026)2.66258781
164multicellular organismal metabolic process (GO:0044236)2.64733605
165terpenoid biosynthetic process (GO:0016114)2.62695779
166regulation of interferon-alpha production (GO:0032647)2.62107740
167regulation of T-helper 1 cell differentiation (GO:0045625)2.61957551
168face development (GO:0060324)2.60686582
169regulation of mast cell activation (GO:0033003)2.60083159
170regulation of somitogenesis (GO:0014807)2.59646893
171reactive oxygen species biosynthetic process (GO:1903409)2.58857318
172regulation of extracellular matrix disassembly (GO:0010715)2.57009786
173positive regulation of T cell cytokine production (GO:0002726)2.56454817
174negative regulation of homotypic cell-cell adhesion (GO:0034111)2.53874840
175neutrophil chemotaxis (GO:0030593)2.53636458
176positive regulation of T cell apoptotic process (GO:0070234)2.51998988
177regulation of monocyte chemotaxis (GO:0090025)2.50139974
178phagosome maturation (GO:0090382)2.50069377
179response to muramyl dipeptide (GO:0032495)2.48431615
180regulation of mast cell activation involved in immune response (GO:0033006)2.48185278
181defense response to protozoan (GO:0042832)2.47331837
182regulation of interferon-gamma biosynthetic process (GO:0045072)2.46806036
183neutrophil migration (GO:1990266)2.45858829
184myeloid cell activation involved in immune response (GO:0002275)2.45845983
185myeloid dendritic cell activation (GO:0001773)2.45056718
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.44313052
187response to host immune response (GO:0052572)2.44313052
188positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.44123271
189negative regulation of production of molecular mediator of immune response (GO:0002701)2.42714677
190regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42447309
191regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.41453031
192type B pancreatic cell proliferation (GO:0044342)2.41165531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.69523730
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.12831384
3* MYC_22102868_ChIP-Seq_BL_Human5.62348509
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.00996561
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.66014494
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.49459868
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.31229631
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.22973411
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.21517491
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.11295973
11VDR_21846776_ChIP-Seq_THP-1_Human2.93559812
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62912085
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.62481896
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.49482277
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47690582
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.35484857
17CIITA_25753668_ChIP-Seq_RAJI_Human2.31324389
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30314752
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24395007
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14817650
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14614704
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14100634
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10006773
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08269199
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07835204
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01734384
27MAF_26560356_Chip-Seq_TH1_Human1.99010296
28SPI1_23547873_ChIP-Seq_NB4_Human1.91369452
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89338791
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.89278376
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86437213
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84195272
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.75474170
34MAF_26560356_Chip-Seq_TH2_Human1.74918092
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72348440
36* UTX_26944678_Chip-Seq_JUKART_Human1.68719977
37* KDM2B_26808549_Chip-Seq_DND41_Human1.68301618
38VDR_24787735_ChIP-Seq_THP-1_Human1.68024786
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62514277
40* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62193914
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.60516019
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58985388
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57240565
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53345321
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51506552
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50091504
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48355102
48LXR_22292898_ChIP-Seq_THP-1_Human1.46716899
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45602609
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.44278292
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43797629
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43572634
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43335564
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40115499
55TCF7_22412390_ChIP-Seq_EML_Mouse1.39980093
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39732047
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38974365
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37067538
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36145711
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.35644225
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35422644
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34836421
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34836421
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33833269
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.33197289
66* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32606148
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31115214
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30323076
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29906618
70TFEB_21752829_ChIP-Seq_HELA_Human1.29294593
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29274157
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28964439
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28700783
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27623379
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27465212
76XRN2_22483619_ChIP-Seq_HELA_Human1.25064964
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.24643452
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23785526
79MYB_26560356_Chip-Seq_TH1_Human1.23592963
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22881027
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22881027
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21712635
83BCOR_27268052_Chip-Seq_Bcells_Human1.19625999
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19189127
85FOXP3_21729870_ChIP-Seq_TREG_Human1.18901326
86AHR_22903824_ChIP-Seq_MCF-7_Human1.16661076
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16371865
88CTCF_21964334_Chip-Seq_Bcells_Human1.15221057
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15195729
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.13573472
91RUNX_20019798_ChIP-Seq_JUKART_Human1.11505746
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.10282623
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09662806
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09045302
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09004760
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.08703511
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08657251
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08162634
99DCP1A_22483619_ChIP-Seq_HELA_Human1.07477328
100BCL6_27268052_Chip-Seq_Bcells_Human1.06518391
101VDR_23849224_ChIP-Seq_CD4+_Human1.06000481
102MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05827015
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05674361
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05532258
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04893195
106GABP_19822575_ChIP-Seq_HepG2_Human1.03589932
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03184085
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.03047120
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02858418
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.02533826
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02273728
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.02189599
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02177385
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02018891
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01650645
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01285926
117TP53_18474530_ChIP-ChIP_U2OS_Human1.00695941
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00676976
119CJUN_26792858_Chip-Seq_BT549_Human1.00348929
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00302278
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00259058
122MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00145842
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99087842
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98766213
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98730787
126VDR_24763502_ChIP-Seq_THP-1_Human0.98681076
127SOX2_20726797_ChIP-Seq_SW620_Human0.97956393
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96866353
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96824276
130* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96767534
131CLOCK_20551151_ChIP-Seq_293T_Human0.96641199
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96502449
133* MYB_26560356_Chip-Seq_TH2_Human0.96494198
134* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96358640
135KDM5A_27292631_Chip-Seq_BREAST_Human0.96133435
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.96022954
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95858551
138FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95440786
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.94691771
140* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94562583
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94098901
142MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94034995
143* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92838573
144RXR_22108803_ChIP-Seq_LS180_Human0.92546548
145* NCOR1_26117541_ChIP-Seq_K562_Human0.90855338
146KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90834502
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90834502
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90834502
149PU_27001747_Chip-Seq_BMDM_Mouse0.90412020
150* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90156816
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90152782
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88103632
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.87321097
154WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86532983
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86392063
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84758575
157IGF1R_20145208_ChIP-Seq_DFB_Human0.84564071
158IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83730469
159SPI1_23127762_ChIP-Seq_K562_Human0.83321765
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82311864
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82260393
162* EZH2_27294783_Chip-Seq_ESCs_Mouse0.82161700
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.81514456
164KLF5_25053715_ChIP-Seq_YYC3_Human0.80300565
165ERG_21242973_ChIP-ChIP_JURKAT_Human0.78568700
166* RNF2_27304074_Chip-Seq_ESCs_Mouse0.78267754
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77570614
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77113873
169* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.76264295
170RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75355140
171STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74907954
172* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74472968
173EZH2_22144423_ChIP-Seq_EOC_Human0.74392982
174SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74166476
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74020731
176SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71093830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.75350065
2MP0003879_abnormal_hair_cell7.54919722
3MP0005423_abnormal_somatic_nervous6.61212914
4MP0010386_abnormal_urinary_bladder5.58203348
5MP0000537_abnormal_urethra_morphology4.85789287
6MP0003303_peritoneal_inflammation3.37201083
7MP0003878_abnormal_ear_physiology3.26032581
8MP0005377_hearing/vestibular/ear_phenot3.26032581
9MP0001485_abnormal_pinna_reflex3.18642674
10MP0003763_abnormal_thymus_physiology3.17378042
11MP0001963_abnormal_hearing_physiology3.15975208
12MP0000026_abnormal_inner_ear3.01594397
13MP0005248_abnormal_Harderian_gland2.97263040
14MP0002148_abnormal_hypersensitivity_rea2.88967516
15MP0006082_CNS_inflammation2.83415812
16MP0003436_decreased_susceptibility_to2.62119339
17MP0001835_abnormal_antigen_presentation2.36893444
18MP0002419_abnormal_innate_immunity2.30547113
19MP0001661_extended_life_span2.29226779
20MP0002735_abnormal_chemical_nociception2.29181373
21MP0001533_abnormal_skeleton_physiology2.24779961
22MP0000538_abnormal_urinary_bladder2.17900715
23MP0005058_abnormal_lysosome_morphology2.07754673
24MP0010234_abnormal_vibrissa_follicle2.06649132
25* MP0005000_abnormal_immune_tolerance2.03801670
26MP0003705_abnormal_hypodermis_morpholog2.01885081
27MP0000465_gastrointestinal_hemorrhage2.00198524
28MP0002933_joint_inflammation1.85640378
29MP0002398_abnormal_bone_marrow1.80984694
30MP0005025_abnormal_response_to1.74260661
31MP0004742_abnormal_vestibular_system1.73988893
32MP0008438_abnormal_cutaneous_collagen1.73294463
33MP0003724_increased_susceptibility_to1.69018794
34MP0010352_gastrointestinal_tract_polyps1.66663370
35MP0009785_altered_susceptibility_to1.65149590
36MP0003448_altered_tumor_morphology1.63270206
37MP0004510_myositis1.62477492
38* MP0002452_abnormal_antigen_presenting1.60265566
39MP0000685_abnormal_immune_system1.57810058
40MP0002166_altered_tumor_susceptibility1.57305214
41MP0000689_abnormal_spleen_morphology1.54374175
42MP0008057_abnormal_DNA_replication1.52790616
43MP0002998_abnormal_bone_remodeling1.50752003
44MP0003453_abnormal_keratinocyte_physiol1.49893424
45MP0000604_amyloidosis1.49662761
46MP0002277_abnormal_respiratory_mucosa1.48329631
47MP0003300_gastrointestinal_ulcer1.46393323
48MP0005387_immune_system_phenotype1.45015662
49MP0001790_abnormal_immune_system1.45015662
50MP0002396_abnormal_hematopoietic_system1.43860617
51MP0009278_abnormal_bone_marrow1.43439488
52MP0004885_abnormal_endolymph1.40115712
53MP0000372_irregular_coat_pigmentation1.38544733
54MP0005464_abnormal_platelet_physiology1.38324272
55MP0004947_skin_inflammation1.37309317
56MP0002722_abnormal_immune_system1.35921495
57MP0005390_skeleton_phenotype1.35901761
58* MP0002723_abnormal_immune_serum1.34597178
59MP0004272_abnormal_basement_membrane1.31110583
60* MP0001819_abnormal_immune_cell1.28541455
61MP0001853_heart_inflammation1.28403256
62MP0005164_abnormal_response_to1.28068751
63MP0003941_abnormal_skin_development1.27224453
64MP0005076_abnormal_cell_differentiation1.26190064
65MP0002429_abnormal_blood_cell1.25772561
66MP0009764_decreased_sensitivity_to1.24336931
67* MP0002420_abnormal_adaptive_immunity1.23912359
68MP0005623_abnormal_meninges_morphology1.23481054
69MP0010678_abnormal_skin_adnexa1.21171389
70MP0001845_abnormal_inflammatory_respons1.20979064
71* MP0001800_abnormal_humoral_immune1.16149985
72MP0003693_abnormal_embryo_hatching1.15137725
73MP0000613_abnormal_salivary_gland1.13538791
74MP0003077_abnormal_cell_cycle1.11078203
75MP0002405_respiratory_system_inflammati1.10487311
76MP0003075_altered_response_to1.08740057
77MP0000703_abnormal_thymus_morphology1.05597988
78MP0000858_altered_metastatic_potential1.04951701
79MP0005671_abnormal_response_to1.03779138
80MP0009840_abnormal_foam_cell1.02476575
81MP0003828_pulmonary_edema0.99849698
82MP0004808_abnormal_hematopoietic_stem0.98284001
83MP0002006_tumorigenesis0.97697932
84MP0003111_abnormal_nucleus_morphology0.96030662
85MP0010094_abnormal_chromosome_stability0.94877882
86MP0003186_abnormal_redox_activity0.94654853
87MP0003690_abnormal_glial_cell0.93378120
88MP0005075_abnormal_melanosome_morpholog0.92804922
89MP0005275_abnormal_skin_tensile0.92484024
90MP0002254_reproductive_system_inflammat0.91824568
91MP0010155_abnormal_intestine_physiology0.90134678
92MP0000313_abnormal_cell_death0.90029079
93MP0004381_abnormal_hair_follicle0.89168723
94MP0008007_abnormal_cellular_replicative0.89050155
95MP0008469_abnormal_protein_level0.87443288
96MP0002796_impaired_skin_barrier0.85600743
97MP0000383_abnormal_hair_follicle0.85442660
98MP0001958_emphysema0.84603360
99MP0002138_abnormal_hepatobiliary_system0.83994098
100MP0003795_abnormal_bone_structure0.83622939
101MP0008995_early_reproductive_senescence0.82490259
102MP0001851_eye_inflammation0.82328364
103MP0005167_abnormal_blood-brain_barrier0.82292814
104MP0000569_abnormal_digit_pigmentation0.82275023
105MP0004858_abnormal_nervous_system0.81519543
106MP0002060_abnormal_skin_morphology0.78995721
107MP0000350_abnormal_cell_proliferation0.78976158
108MP0000343_altered_response_to0.77752411
109MP0008874_decreased_physiological_sensi0.77255021
110MP0003942_abnormal_urinary_system0.77127151
111MP0000678_abnormal_parathyroid_gland0.76138814
112MP0003566_abnormal_cell_adhesion0.75964071
113MP0000920_abnormal_myelination0.75468637
114MP0002019_abnormal_tumor_incidence0.74645600
115MP0005508_abnormal_skeleton_morphology0.74517339
116MP0003786_premature_aging0.72784128
117MP0001849_ear_inflammation0.72650563
118MP0000767_abnormal_smooth_muscle0.72481108
119MP0002877_abnormal_melanocyte_morpholog0.71904670
120MP0009333_abnormal_splenocyte_physiolog0.71717649
121MP0002102_abnormal_ear_morphology0.71568705
122MP0005310_abnormal_salivary_gland0.71079173
123MP0000534_abnormal_ureter_morphology0.70717922
124MP0005023_abnormal_wound_healing0.70569365
125MP0000716_abnormal_immune_system0.70442203
126MP0002115_abnormal_skeleton_extremities0.70410337
127MP0001299_abnormal_eye_distance/0.67223769
128MP0000490_abnormal_crypts_of0.66844115
129MP0005645_abnormal_hypothalamus_physiol0.65646938
130MP0006054_spinal_hemorrhage0.65349460
131MP0000163_abnormal_cartilage_morphology0.65307482
132MP0005166_decreased_susceptibility_to0.65214685
133MP0004036_abnormal_muscle_relaxation0.64562627
134MP0002113_abnormal_skeleton_development0.63467435
135MP0002136_abnormal_kidney_physiology0.62887751
136MP0003938_abnormal_ear_development0.62836668
137MP0005197_abnormal_uvea_morphology0.62004681
138MP0001730_embryonic_growth_arrest0.61570184
139MP0000049_abnormal_middle_ear0.60552472
140MP0003221_abnormal_cardiomyocyte_apopto0.60431111
141MP0003191_abnormal_cellular_cholesterol0.60212504
142MP0000609_abnormal_liver_physiology0.59940751
143MP0005408_hypopigmentation0.59325463
144MP0002098_abnormal_vibrissa_morphology0.59079071
145MP0000249_abnormal_blood_vessel0.58779672
146MP0004957_abnormal_blastocyst_morpholog0.57873492
147MP0005083_abnormal_biliary_tract0.57238470
148MP0009763_increased_sensitivity_to0.55005789
149MP0000762_abnormal_tongue_morphology0.54387450
150MP0000371_diluted_coat_color0.49779439
151MP0003172_abnormal_lysosome_physiology0.49495458
152MP0002095_abnormal_skin_pigmentation0.48931374
153MP0000013_abnormal_adipose_tissue0.47939100
154MP0004134_abnormal_chest_morphology0.45192959
155MP0003866_abnormal_defecation0.45099945
156MP0008932_abnormal_embryonic_tissue0.44989374
157MP0009250_abnormal_appendicular_skeleto0.43764504
158MP0001270_distended_abdomen0.43352370
159MP0001727_abnormal_embryo_implantation0.40362077
160MP0003091_abnormal_cell_migration0.40255580
161MP0006035_abnormal_mitochondrial_morpho0.37178686
162MP0002083_premature_death0.37105365
163MP0005621_abnormal_cell_physiology0.36686997

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.72875639
2Agammaglobulinemia (HP:0004432)7.47060941
3Gastrointestinal stroma tumor (HP:0100723)6.62300323
4Vitreoretinal degeneration (HP:0000655)6.16706888
5Recurrent bronchitis (HP:0002837)6.08017557
6Severe Myopia (HP:0011003)5.65593689
7Enlarged epiphyses (HP:0010580)5.59482443
8Recurrent bacterial skin infections (HP:0005406)5.24668005
9Eczematoid dermatitis (HP:0000976)5.19784708
10Colitis (HP:0002583)5.18722834
11Recurrent abscess formation (HP:0002722)4.92492001
12Chronic otitis media (HP:0000389)4.88610274
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.81503061
14Hypoplastic ischia (HP:0003175)4.69534925
15Delayed epiphyseal ossification (HP:0002663)4.65518934
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.58811380
17Mild short stature (HP:0003502)4.58145827
18Panhypogammaglobulinemia (HP:0003139)4.55066424
19Hypoplasia of the thymus (HP:0000778)4.51963303
20Irregular epiphyses (HP:0010582)4.45956359
21Viral hepatitis (HP:0006562)4.45212507
22Lymphopenia (HP:0001888)4.44473489
23Follicular hyperkeratosis (HP:0007502)4.37038595
24Meningitis (HP:0001287)4.33644046
25Recurrent sinusitis (HP:0011108)4.29928699
26Emphysema (HP:0002097)4.23966127
27Recurrent gram-negative bacterial infections (HP:0005420)4.16939540
28Pili torti (HP:0003777)4.16274457
29Abnormality of the ischium (HP:0003174)4.08205809
30Chronic sinusitis (HP:0011109)3.97871089
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.90459070
32Abnormality of the peritoneum (HP:0002585)3.80700033
33Gastrointestinal inflammation (HP:0004386)3.66486699
34Increased cerebral lipofuscin (HP:0011813)3.61467397
35Mixed hearing impairment (HP:0000410)3.58261319
36Limb hypertonia (HP:0002509)3.58177200
37Abnormality of the vitreous humor (HP:0004327)3.56050386
38Inflammation of the large intestine (HP:0002037)3.51437762
39Flattened epiphyses (HP:0003071)3.50487972
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.49350256
41Thin bony cortex (HP:0002753)3.45635445
42Osteoarthritis (HP:0002758)3.44100066
43Mediastinal lymphadenopathy (HP:0100721)3.43810490
44Small epiphyses (HP:0010585)3.37444416
45Increased neuronal autofluorescent lipopigment (HP:0002074)3.35163215
46Abnormality of macrophages (HP:0004311)3.14585189
47Bronchitis (HP:0012387)3.14297931
48Osteomyelitis (HP:0002754)3.13350747
49Verrucae (HP:0200043)3.10770640
50Papilloma (HP:0012740)3.10770640
51Medulloblastoma (HP:0002885)3.07231347
52Recurrent skin infections (HP:0001581)3.03415818
53Arterial tortuosity (HP:0005116)3.02052227
54Aplasia/Hypoplasia of the patella (HP:0006498)3.00026975
55Genu varum (HP:0002970)2.97782280
56Nasal polyposis (HP:0100582)2.96386192
57Absent epiphyses (HP:0010577)2.95406004
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.95406004
59Lip pit (HP:0100267)2.91734111
60Lymphoma (HP:0002665)2.87816472
61Lymphedema (HP:0001004)2.80068187
62Abnormal hair laboratory examination (HP:0003328)2.80060869
63Abnormality of the pubic bones (HP:0003172)2.79067537
64Bell-shaped thorax (HP:0001591)2.78807206
65Elbow flexion contracture (HP:0002987)2.74606028
66Protuberant abdomen (HP:0001538)2.74199649
67Fatigue (HP:0012378)2.72828259
68Vasculitis (HP:0002633)2.72128625
69Recurrent pneumonia (HP:0006532)2.71010179
70Abnormality of the prostate (HP:0008775)2.68621526
71Chronic obstructive pulmonary disease (HP:0006510)2.67080678
72Obstructive lung disease (HP:0006536)2.67080678
73Supranuclear gaze palsy (HP:0000605)2.67061857
74Gingivitis (HP:0000230)2.63853779
75Vascular tortuosity (HP:0004948)2.62570349
76Cellulitis (HP:0100658)2.61383840
77Recurrent corneal erosions (HP:0000495)2.57270513
78Slow-growing hair (HP:0002217)2.51662391
79Abnormality of hair growth rate (HP:0011363)2.51662391
80Abnormality of the nasal mucosa (HP:0000433)2.50299381
81Vacuolated lymphocytes (HP:0001922)2.49601477
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48842687
83IgM deficiency (HP:0002850)2.48703654
84Platyspondyly (HP:0000926)2.47905764
85Slow saccadic eye movements (HP:0000514)2.45985060
86Morphological abnormality of the middle ear (HP:0008609)2.44081133
87Periodontitis (HP:0000704)2.41925285
88Villous atrophy (HP:0011473)2.41583507
89Abnormality of small intestinal villus morphology (HP:0011472)2.41583507
90Recurrent fungal infections (HP:0002841)2.41186107
91Recurrent otitis media (HP:0000403)2.40366650
92Alopecia of scalp (HP:0002293)2.40184510
93Restrictive lung disease (HP:0002091)2.38521172
94Congenital, generalized hypertrichosis (HP:0004540)2.38299177
95Exostoses (HP:0100777)2.38267711
96Abnormality of the fingertips (HP:0001211)2.37068801
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35326012
98Aplasia/Hypoplasia of the thymus (HP:0010515)2.34284604
99Hematochezia (HP:0002573)2.33716996
100Progressive hearing impairment (HP:0001730)2.33687001
101Sepsis (HP:0100806)2.30576685
102Vertebral clefting (HP:0008428)2.29870449
103Cervical subluxation (HP:0003308)2.23808099
104Menstrual irregularities (HP:0000858)2.21906996
105Arthralgia (HP:0002829)2.21847951
106Loss of speech (HP:0002371)2.21555018
107Hepatitis (HP:0012115)2.19726200
108Urticaria (HP:0001025)2.17907367
109Vertebral compression fractures (HP:0002953)2.16888489
110Abnormality of the pleura (HP:0002103)2.15309543
111Stomatitis (HP:0010280)2.11848840
112Erythema (HP:0010783)2.07120605
113Progressive neurologic deterioration (HP:0002344)2.05865517
114Glossoptosis (HP:0000162)2.03091548
115T lymphocytopenia (HP:0005403)2.02986065
116Widely patent fontanelles and sutures (HP:0004492)2.02853336
117Leukopenia (HP:0001882)1.99300675
118Encephalitis (HP:0002383)1.97766458
119Sensorimotor neuropathy (HP:0007141)1.97434309
120Abnormal spermatogenesis (HP:0008669)1.97118671
121Glucose intolerance (HP:0000833)1.96407212
122Synostosis of carpal bones (HP:0005048)1.94955389
123Neoplasm of the tracheobronchial system (HP:0100552)1.94792363
124Retinopathy (HP:0000488)1.94584889
125Abnormality of T cells (HP:0002843)1.94107094
126Bone pain (HP:0002653)1.93813410
127Recurrent viral infections (HP:0004429)1.91642420
128Abnormality of the thymus (HP:0000777)1.90713917
129Recurrent lower respiratory tract infections (HP:0002783)1.89906455
130Myocardial infarction (HP:0001658)1.89686674
131Dysostosis multiplex (HP:0000943)1.89530343
132Interstitial pulmonary disease (HP:0006530)1.89287962
133Femoral bowing (HP:0002980)1.88373271
134Abnormality of T cell physiology (HP:0011840)1.88189046
135Severe muscular hypotonia (HP:0006829)1.87047883
136Abnormality of the costochondral junction (HP:0000919)1.86777293
137Morphological abnormality of the inner ear (HP:0011390)1.85133113
138Keratoconjunctivitis sicca (HP:0001097)1.85081798
139Spondylolisthesis (HP:0003302)1.84734088
140Abnormality of the vertebral endplates (HP:0005106)1.84544689
141Skin ulcer (HP:0200042)1.80520453
142Neurofibrillary tangles (HP:0002185)1.78316092
143Large earlobe (HP:0009748)1.77996984
144Abnormality of proline metabolism (HP:0010907)1.77698915
145Hydroxyprolinuria (HP:0003080)1.77698915
146Abnormal glucose tolerance (HP:0001952)1.76536784
147Protrusio acetabuli (HP:0003179)1.76234748
148Long foot (HP:0001833)1.76231248
149Abnormality of male internal genitalia (HP:0000022)1.75408352
150IgA deficiency (HP:0002720)1.75105849
151Amyloidosis (HP:0011034)1.72273657
152Urinary glycosaminoglycan excretion (HP:0003541)1.71434775
153Mucopolysacchariduria (HP:0008155)1.71434775
154Termporal pattern (HP:0011008)1.69203071
155Insidious onset (HP:0003587)1.69203071
156Systemic lupus erythematosus (HP:0002725)1.69006439
157Orchitis (HP:0100796)1.68196167
158Chronic mucocutaneous candidiasis (HP:0002728)1.68159791
159Recurrent cutaneous fungal infections (HP:0011370)1.68159791
160Impulsivity (HP:0100710)1.67561192
161Broad metatarsal (HP:0001783)1.67055740
162Abnormality of T cell number (HP:0011839)1.64700888
163Progressive external ophthalmoplegia (HP:0000590)1.63164592
164Keratoconjunctivitis (HP:0001096)1.63112168
165Abnormality of liposaccharide metabolism (HP:0010968)1.62721757
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.62721757
167Abnormality of glycolipid metabolism (HP:0010969)1.62721757
168Cutaneous melanoma (HP:0012056)1.62215884
169Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.62200955
170Axonal loss (HP:0003447)1.60966225
171Upper motor neuron abnormality (HP:0002127)1.60328329
172Skin rash (HP:0000988)1.59866988
173Premature loss of primary teeth (HP:0006323)1.58997185
174Deep palmar crease (HP:0006191)1.58824930
175Tibial bowing (HP:0002982)1.58687573
176Shallow orbits (HP:0000586)1.58081166
177Flared metaphyses (HP:0003015)1.57132820
178Myositis (HP:0100614)1.56105779
179Premature rupture of membranes (HP:0001788)1.54929624
180Akinesia (HP:0002304)1.52910976
181Thick nail (HP:0001805)1.52368547
182Sprengel anomaly (HP:0000912)1.51819996
183Unilateral renal agenesis (HP:0000122)1.51712183
184Segmental peripheral demyelination/remyelination (HP:0003481)1.50907446
185Retrobulbar optic neuritis (HP:0100654)1.49719235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.37034096
2BLK4.28828121
3RIPK43.91000254
4PBK3.49569305
5MAP3K133.33507437
6EPHB12.85218155
7NEK92.59976355
8EPHA32.57072282
9TRIB32.16834424
10IRAK32.07052664
11PIK3CG1.98452139
12MAP3K141.92083747
13LMTK21.91938475
14ARAF1.78386393
15TRPM71.65141094
16MAP3K91.64792522
17CDK121.61775947
18MAP3K121.59336468
19KSR21.53093947
20MAP2K31.52697886
21PIM21.52136030
22BMPR21.47564238
23BMX1.44759406
24MAPK111.42987103
25PTK61.34534901
26EEF2K1.33752524
27TBK11.33259477
28OXSR11.32335919
29PRPF4B1.17191680
30TYK21.14908213
31CAMK1G1.14163788
32IRAK41.11844266
33ERN11.06159886
34NTRK11.05563156
35JAK11.03420019
36PRKD31.01995440
37CDK60.99909154
38ABL20.99504659
39FGFR40.98933225
40FGR0.98560352
41CAMK1D0.98419779
42IRAK10.97382710
43STK30.96934376
44LRRK20.96616839
45SMG10.94992843
46MST1R0.94051781
47CSK0.93905334
48FRK0.93433539
49MARK30.92567848
50SCYL20.89889280
51PKN20.89480979
52DYRK1B0.87863038
53STK240.87607572
54PDK10.87229922
55PNCK0.86184588
56KIT0.85676067
57MATK0.85190975
58YES10.84124218
59PAK40.81611579
60LATS10.80674597
61NME20.79061168
62IKBKB0.78196774
63MAP2K10.75345058
64JAK20.71860664
65CDK40.71062772
66STK40.70293865
67MAP3K10.70239328
68MUSK0.70090318
69IRAK20.69584190
70WNK10.68880185
71MAP4K10.67796343
72GRK60.67324223
73CHUK0.66397260
74MOS0.65053148
75RPS6KA40.63848087
76BTK0.63701033
77TAOK20.63416496
78MAPK120.62765785
79TESK10.61526923
80SYK0.61260165
81ERBB30.59794678
82ABL10.59148465
83LYN0.57806936
84FGFR30.56655276
85GRK10.54679371
86RPS6KA50.54309195
87IKBKE0.53170052
88FES0.52805183
89NLK0.52588847
90PIM10.52579084
91JAK30.52160008
92PAK60.51395046
93MAP3K100.49993314
94BRAF0.49708161
95EIF2AK20.49468293
96ERBB20.48543079
97FER0.48110864
98ALK0.47903242
99STK390.47711182
100INSR0.46886453
101PRKCH0.45804928
102MAP3K20.45520609
103DAPK30.45068364
104EGFR0.44188796
105HCK0.44028055
106PTK2B0.43908963
107MET0.43491756
108DAPK20.43443428
109MAPK40.42268654
110ITK0.41289798
111LCK0.41081133
112RAF10.40247223
113FYN0.39383623
114BRD40.39254848
115MAP2K20.38797545
116PAK30.38365911
117PRKCD0.36704614
118EPHB20.36068114
119MAP3K110.36031708
120CSF1R0.35737623
121BUB10.35737501
122TTN0.33611890
123PDGFRA0.32816018
124TESK20.32679663
125TEC0.32623275
126KSR10.31891648
127PDPK10.29074207
128EIF2AK10.28287859
129EPHA40.27956322
130TNK20.27935222
131GSK3A0.27590970
132PRKD10.24963633
133MAP3K80.23992713
134RPS6KC10.23852208
135RPS6KL10.23852208
136TAOK10.23602328
137RPS6KA20.22888626
138MAPKAPK20.22714151
139STK100.21431736
140SIK10.20594748
141MAPK70.19916416
142AKT20.19686603
143PASK0.19162120
144GRK70.15982093
145CDC42BPA0.15034169
146ICK0.14977517
147CSNK1A10.14867520
148TLK10.13909935
149RPS6KA60.12965820
150HIPK20.12840670
151SRPK10.10966059
152MAPK30.10604509
153NEK20.09621704

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.83262083
2Leishmaniasis_Homo sapiens_hsa051402.90478717
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.58598950
4Rheumatoid arthritis_Homo sapiens_hsa053232.35421446
5Osteoclast differentiation_Homo sapiens_hsa043802.32435025
6Staphylococcus aureus infection_Homo sapiens_hsa051502.27410844
7Graft-versus-host disease_Homo sapiens_hsa053322.26264132
8Tuberculosis_Homo sapiens_hsa051522.16244028
9Notch signaling pathway_Homo sapiens_hsa043302.16132353
10Malaria_Homo sapiens_hsa051442.14000701
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10481397
12Herpes simplex infection_Homo sapiens_hsa051682.09811681
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87702410
14Mismatch repair_Homo sapiens_hsa034301.81956760
15Base excision repair_Homo sapiens_hsa034101.79434316
16Type I diabetes mellitus_Homo sapiens_hsa049401.76920806
17Allograft rejection_Homo sapiens_hsa053301.69702100
18Asthma_Homo sapiens_hsa053101.67624466
19Taste transduction_Homo sapiens_hsa047421.64567448
20TNF signaling pathway_Homo sapiens_hsa046681.63518764
21Pertussis_Homo sapiens_hsa051331.63343500
22B cell receptor signaling pathway_Homo sapiens_hsa046621.61394593
23Systemic lupus erythematosus_Homo sapiens_hsa053221.60503404
24Lysosome_Homo sapiens_hsa041421.57002546
25Legionellosis_Homo sapiens_hsa051341.54014795
26ECM-receptor interaction_Homo sapiens_hsa045121.51819670
27Amoebiasis_Homo sapiens_hsa051461.51652314
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51052173
29Phagosome_Homo sapiens_hsa041451.50825782
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.50222464
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50134732
32Antigen processing and presentation_Homo sapiens_hsa046121.48100981
33DNA replication_Homo sapiens_hsa030301.45096295
34Homologous recombination_Homo sapiens_hsa034401.44456212
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39816340
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38103059
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36916289
38Protein digestion and absorption_Homo sapiens_hsa049741.35975000
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34676680
40Collecting duct acid secretion_Homo sapiens_hsa049661.33797324
41Toxoplasmosis_Homo sapiens_hsa051451.31948077
42Chemokine signaling pathway_Homo sapiens_hsa040621.28609473
43Salmonella infection_Homo sapiens_hsa051321.27472105
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27150733
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.26285440
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23205394
47Histidine metabolism_Homo sapiens_hsa003401.17092445
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16182442
49Epstein-Barr virus infection_Homo sapiens_hsa051691.14647899
50Hematopoietic cell lineage_Homo sapiens_hsa046401.14152718
51Measles_Homo sapiens_hsa051621.13092969
52Alcoholism_Homo sapiens_hsa050341.12938997
53Prolactin signaling pathway_Homo sapiens_hsa049171.09056205
54African trypanosomiasis_Homo sapiens_hsa051431.07919165
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06649330
56Chronic myeloid leukemia_Homo sapiens_hsa052201.05326546
57Viral carcinogenesis_Homo sapiens_hsa052031.03673075
58Dorso-ventral axis formation_Homo sapiens_hsa043201.03448691
59Folate biosynthesis_Homo sapiens_hsa007901.01848942
60Autoimmune thyroid disease_Homo sapiens_hsa053201.00160456
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97084005
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96377588
63Steroid biosynthesis_Homo sapiens_hsa001000.96259110
64Proteoglycans in cancer_Homo sapiens_hsa052050.94825464
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93633929
66Ribosome_Homo sapiens_hsa030100.93290100
67Focal adhesion_Homo sapiens_hsa045100.90385639
68Prion diseases_Homo sapiens_hsa050200.89826676
69Nucleotide excision repair_Homo sapiens_hsa034200.89695699
70One carbon pool by folate_Homo sapiens_hsa006700.87053858
71Hepatitis C_Homo sapiens_hsa051600.86940528
72Pancreatic cancer_Homo sapiens_hsa052120.85969671
73mRNA surveillance pathway_Homo sapiens_hsa030150.84955680
74Pentose phosphate pathway_Homo sapiens_hsa000300.84862178
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.84820480
76Non-small cell lung cancer_Homo sapiens_hsa052230.84776314
77Phenylalanine metabolism_Homo sapiens_hsa003600.84024386
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82362569
79Other glycan degradation_Homo sapiens_hsa005110.79630458
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79463419
81Pyrimidine metabolism_Homo sapiens_hsa002400.79088681
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78974760
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77219634
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77079083
85Hepatitis B_Homo sapiens_hsa051610.76827908
86Influenza A_Homo sapiens_hsa051640.76295251
87beta-Alanine metabolism_Homo sapiens_hsa004100.76213638
88mTOR signaling pathway_Homo sapiens_hsa041500.72892261
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72617249
90Complement and coagulation cascades_Homo sapiens_hsa046100.72601107
91Vibrio cholerae infection_Homo sapiens_hsa051100.71023109
92Colorectal cancer_Homo sapiens_hsa052100.70937680
93Shigellosis_Homo sapiens_hsa051310.69589030
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69568467
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.69547308
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.69106946
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68284463
98HTLV-I infection_Homo sapiens_hsa051660.68252170
99Apoptosis_Homo sapiens_hsa042100.67305845
100VEGF signaling pathway_Homo sapiens_hsa043700.66390974
101Sphingolipid metabolism_Homo sapiens_hsa006000.64903503
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.63128114
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.62908410
104Platelet activation_Homo sapiens_hsa046110.61782627
105Viral myocarditis_Homo sapiens_hsa054160.61390768
106HIF-1 signaling pathway_Homo sapiens_hsa040660.60662860
107Wnt signaling pathway_Homo sapiens_hsa043100.60309978
108Mineral absorption_Homo sapiens_hsa049780.59404080
109ErbB signaling pathway_Homo sapiens_hsa040120.58707422
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57930135
111Insulin signaling pathway_Homo sapiens_hsa049100.57169302
112Bladder cancer_Homo sapiens_hsa052190.56962951
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.56770732
114Glioma_Homo sapiens_hsa052140.56173920
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55963012
116Acute myeloid leukemia_Homo sapiens_hsa052210.55788904
117Type II diabetes mellitus_Homo sapiens_hsa049300.54962481
118Fructose and mannose metabolism_Homo sapiens_hsa000510.53743805
119TGF-beta signaling pathway_Homo sapiens_hsa043500.53447228
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.52704888
121Hippo signaling pathway_Homo sapiens_hsa043900.52537506
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51646651
123Small cell lung cancer_Homo sapiens_hsa052220.51189048
124Basal cell carcinoma_Homo sapiens_hsa052170.50958342
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50597387
126Non-homologous end-joining_Homo sapiens_hsa034500.50210199
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49580778
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48587050
129Renal cell carcinoma_Homo sapiens_hsa052110.48293881
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47886314
131Melanoma_Homo sapiens_hsa052180.47457787
132T cell receptor signaling pathway_Homo sapiens_hsa046600.47429475
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46184852
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.44481693
135Adherens junction_Homo sapiens_hsa045200.43397992
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42489420
137Prostate cancer_Homo sapiens_hsa052150.40592416
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40428571
139Endometrial cancer_Homo sapiens_hsa052130.39876650
140Estrogen signaling pathway_Homo sapiens_hsa049150.39750392
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38731406
142Sulfur relay system_Homo sapiens_hsa041220.37938301
143Choline metabolism in cancer_Homo sapiens_hsa052310.37889924
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36831112
145Basal transcription factors_Homo sapiens_hsa030220.36786411
146Inositol phosphate metabolism_Homo sapiens_hsa005620.36588840
147FoxO signaling pathway_Homo sapiens_hsa040680.31761232

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