FCRL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)7.50082032
2regulation of MHC class I biosynthetic process (GO:0045343)6.60618902
3negative regulation of multicellular organism growth (GO:0040015)6.01033255
4cellular ketone body metabolic process (GO:0046950)5.56112276
5regulation of establishment of cell polarity (GO:2000114)5.41846206
6regulation of interleukin-13 production (GO:0032656)5.39853429
7cytoplasmic mRNA processing body assembly (GO:0033962)5.30656282
8indole-containing compound catabolic process (GO:0042436)4.90188640
9indolalkylamine catabolic process (GO:0046218)4.90188640
10tryptophan catabolic process (GO:0006569)4.90188640
11ketone body metabolic process (GO:1902224)4.84854437
12negative regulation of type 2 immune response (GO:0002829)4.63289864
13kynurenine metabolic process (GO:0070189)4.59647544
14type I interferon signaling pathway (GO:0060337)4.59072310
15cellular response to type I interferon (GO:0071357)4.59072310
16response to type I interferon (GO:0034340)4.57211082
17regulation of establishment or maintenance of cell polarity (GO:0032878)4.20113158
18tryptophan metabolic process (GO:0006568)3.97914046
19nucleoside diphosphate catabolic process (GO:0009134)3.94957357
20sex differentiation (GO:0007548)3.93320830
21alternative mRNA splicing, via spliceosome (GO:0000380)3.90283772
22interferon-gamma-mediated signaling pathway (GO:0060333)3.88118727
23regulation of B cell receptor signaling pathway (GO:0050855)3.87795324
24negative regulation of mast cell activation (GO:0033004)3.67642423
25NAD biosynthetic process (GO:0009435)3.67392983
26negative regulation of execution phase of apoptosis (GO:1900118)3.63215390
27ADP metabolic process (GO:0046031)3.58595618
28regulation of action potential (GO:0098900)3.54663584
29B cell receptor signaling pathway (GO:0050853)3.53974804
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51477023
31cholesterol catabolic process (GO:0006707)3.45446183
32sterol catabolic process (GO:0016127)3.45446183
33positive regulation of heat generation (GO:0031652)3.41338488
34B cell homeostasis (GO:0001782)3.40341437
35indolalkylamine metabolic process (GO:0006586)3.38490247
36DNA demethylation (GO:0080111)3.38174773
37cytidine deamination (GO:0009972)3.37335582
38cytidine metabolic process (GO:0046087)3.37335582
39cytidine catabolic process (GO:0006216)3.37335582
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26284542
41snRNA transcription (GO:0009301)3.23052290
42positive regulation of vasculogenesis (GO:2001214)3.18407369
43L-fucose catabolic process (GO:0042355)3.15496777
44fucose catabolic process (GO:0019317)3.15496777
45L-fucose metabolic process (GO:0042354)3.15496777
46CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.14900232
47neural tube formation (GO:0001841)3.11083953
48interferon-gamma production (GO:0032609)3.10438948
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09849026
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.09849026
51endoderm formation (GO:0001706)3.09225794
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07648193
53negative regulation of calcium ion transport into cytosol (GO:0010523)3.03826205
54regulation of metalloenzyme activity (GO:0048552)2.99850149
55positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.99549500
56dicarboxylic acid biosynthetic process (GO:0043650)2.99420848
57defense response to protozoan (GO:0042832)2.97793542
58negative regulation of macroautophagy (GO:0016242)2.96702506
59amine catabolic process (GO:0009310)2.96694269
60cellular biogenic amine catabolic process (GO:0042402)2.96694269
61antigen processing and presentation of endogenous antigen (GO:0019883)2.96576665
62immunoglobulin mediated immune response (GO:0016064)2.95237855
63T cell costimulation (GO:0031295)2.90290414
64negative regulation of T cell differentiation (GO:0045581)2.90058363
65B cell proliferation (GO:0042100)2.86866818
66aromatic amino acid family catabolic process (GO:0009074)2.86498703
67lymphocyte costimulation (GO:0031294)2.85794522
68positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84592591
69positive regulation of defense response to virus by host (GO:0002230)2.83346404
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81803634
71DNA dealkylation (GO:0035510)2.81767503
72regulation of interleukin-5 production (GO:0032674)2.78716725
73photoreceptor cell maintenance (GO:0045494)2.75944362
74pyrimidine ribonucleoside catabolic process (GO:0046133)2.74587221
75response to interferon-gamma (GO:0034341)2.74479933
76regulation of sarcomere organization (GO:0060297)2.73113331
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72819089
78cellular response to interferon-gamma (GO:0071346)2.71658125
79positive regulation of antigen processing and presentation (GO:0002579)2.69624743
80synaptic transmission, cholinergic (GO:0007271)2.69080628
81regulation of heat generation (GO:0031650)2.68680774
82regulation of T cell mediated cytotoxicity (GO:0001914)2.68445760
83regulation of germinal center formation (GO:0002634)2.67933167
84regulation of antigen processing and presentation (GO:0002577)2.67681253
85response to protozoan (GO:0001562)2.67287969
86establishment of protein localization to Golgi (GO:0072600)2.66805816
87cerebellar Purkinje cell differentiation (GO:0021702)2.66208451
88regulation of type 2 immune response (GO:0002828)2.65953426
89nicotinamide nucleotide biosynthetic process (GO:0019359)2.65612539
90pyridine nucleotide biosynthetic process (GO:0019363)2.65612539
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64885217
92stress granule assembly (GO:0034063)2.64123651
93purine nucleoside diphosphate metabolic process (GO:0009135)2.61420256
94purine ribonucleoside diphosphate metabolic process (GO:0009179)2.61420256
95histone H3-K4 trimethylation (GO:0080182)2.60724684
96protein-chromophore linkage (GO:0018298)2.60056557
97proline transport (GO:0015824)2.59085014
98T-helper 1 type immune response (GO:0042088)2.57074679
99protein autoprocessing (GO:0016540)2.55751909
100B cell mediated immunity (GO:0019724)2.54845973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.79739838
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.26585766
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.36505882
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.88569397
5EZH2_22144423_ChIP-Seq_EOC_Human2.82889844
6VDR_22108803_ChIP-Seq_LS180_Human2.82218733
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.66995532
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58122106
9EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.33818516
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05970178
11BCAT_22108803_ChIP-Seq_LS180_Human2.03007322
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96524865
13IGF1R_20145208_ChIP-Seq_DFB_Human1.89970381
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.81863992
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81359571
16ER_23166858_ChIP-Seq_MCF-7_Human1.77369403
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70854759
18ZNF274_21170338_ChIP-Seq_K562_Hela1.67334430
19IRF1_19129219_ChIP-ChIP_H3396_Human1.67101823
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.67000083
21MYB_26560356_Chip-Seq_TH2_Human1.66271864
22TAF15_26573619_Chip-Seq_HEK293_Human1.56471776
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56099766
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50151558
25GBX2_23144817_ChIP-Seq_PC3_Human1.49576277
26FOXA1_21572438_ChIP-Seq_LNCaP_Human1.49507213
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47940723
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.47940723
29SMRT_27268052_Chip-Seq_Bcells_Human1.47719518
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.45176636
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45000860
32FUS_26573619_Chip-Seq_HEK293_Human1.43674825
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43568462
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42424084
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41840846
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.41792867
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40706891
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37815608
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36362228
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29914679
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.29720427
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28768852
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26360937
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.26349701
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25490615
46NCOR_22424771_ChIP-Seq_293T_Human1.25154232
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.24876688
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24606963
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.23957286
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22148640
51MYC_19829295_ChIP-Seq_ESCs_Human1.21814972
52STAT3_23295773_ChIP-Seq_U87_Human1.20687043
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20266529
54GATA3_26560356_Chip-Seq_TH2_Human1.19635616
55CBP_20019798_ChIP-Seq_JUKART_Human1.18485154
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18485154
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17596145
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16029160
59AR_25329375_ChIP-Seq_VCAP_Human1.15957199
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15650327
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15220595
62CDX2_22108803_ChIP-Seq_LS180_Human1.14790433
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14785252
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14612463
65TAF2_19829295_ChIP-Seq_ESCs_Human1.12686058
66TP53_18474530_ChIP-ChIP_U2OS_Human1.11922544
67TCF4_23295773_ChIP-Seq_U87_Human1.11602670
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.10010571
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.09610427
70TCF4_22108803_ChIP-Seq_LS180_Human1.07713462
71* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07457650
72OCT4_20526341_ChIP-Seq_ESCs_Human1.07319065
73OCT1_27270436_Chip-Seq_PROSTATE_Human1.07128024
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.06837476
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06707414
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.06368771
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06338355
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.06021800
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.05338929
80REST_21632747_ChIP-Seq_MESCs_Mouse1.04052255
81KDM2B_26808549_Chip-Seq_REH_Human1.02985213
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01655930
83DROSHA_22980978_ChIP-Seq_HELA_Human1.01582883
84P300_27268052_Chip-Seq_Bcells_Human1.01487673
85MYB_26560356_Chip-Seq_TH1_Human1.01232271
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.00479583
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00186559
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99527645
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.98862628
90GATA3_26560356_Chip-Seq_TH1_Human0.98711424
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98473043
92GATA3_27048872_Chip-Seq_THYMUS_Human0.98178438
93CEBPB_22108803_ChIP-Seq_LS180_Human0.98095661
94AR_20517297_ChIP-Seq_VCAP_Human0.97652164
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.97615110
96ERA_21632823_ChIP-Seq_H3396_Human0.97119869
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95993902
98RUNX2_22187159_ChIP-Seq_PCA_Human0.95249199
99P53_22387025_ChIP-Seq_ESCs_Mouse0.95006875
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94698720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.94970992
2MP0002138_abnormal_hepatobiliary_system3.83342938
3MP0003252_abnormal_bile_duct3.71239142
4MP0002139_abnormal_hepatobiliary_system3.69022299
5MP0001835_abnormal_antigen_presentation2.97529349
6MP0005645_abnormal_hypothalamus_physiol2.86074661
7MP0005379_endocrine/exocrine_gland_phen2.60879006
8MP0001790_abnormal_immune_system2.57702159
9MP0005387_immune_system_phenotype2.57702159
10MP0005671_abnormal_response_to2.56236207
11MP0002166_altered_tumor_susceptibility2.46418990
12MP0003011_delayed_dark_adaptation2.30848949
13MP0001986_abnormal_taste_sensitivity2.30131523
14MP0001800_abnormal_humoral_immune2.27841039
15MP0006072_abnormal_retinal_apoptosis2.20679182
16MP0000569_abnormal_digit_pigmentation2.13770071
17MP0001348_abnormal_lacrimal_gland1.98717107
18MP0002163_abnormal_gland_morphology1.96709354
19MP0002837_dystrophic_cardiac_calcinosis1.95987684
20MP0005310_abnormal_salivary_gland1.94707680
21MP0000371_diluted_coat_color1.80576150
22MP0005253_abnormal_eye_physiology1.78074472
23MP0001873_stomach_inflammation1.75175658
24MP0005000_abnormal_immune_tolerance1.72213139
25MP0002693_abnormal_pancreas_physiology1.70047531
26MP0003183_abnormal_peptide_metabolism1.68031074
27MP0002006_tumorigenesis1.63412297
28MP0005410_abnormal_fertilization1.63022896
29MP0002452_abnormal_antigen_presenting1.58865035
30MP0009046_muscle_twitch1.57350151
31MP0005075_abnormal_melanosome_morpholog1.55853084
32MP0002723_abnormal_immune_serum1.55479228
33MP0003868_abnormal_feces_composition1.53095370
34MP0001944_abnormal_pancreas_morphology1.51441868
35MP0008877_abnormal_DNA_methylation1.50854312
36MP0003195_calcinosis1.47297531
37MP0002876_abnormal_thyroid_physiology1.43330148
38MP0002254_reproductive_system_inflammat1.36065031
39MP0000372_irregular_coat_pigmentation1.35078656
40MP0002420_abnormal_adaptive_immunity1.34363349
41MP0001819_abnormal_immune_cell1.30992586
42MP0000013_abnormal_adipose_tissue1.30882661
43MP0001501_abnormal_sleep_pattern1.29069918
44MP0009780_abnormal_chondrocyte_physiolo1.28794459
45MP0005084_abnormal_gallbladder_morpholo1.27921189
46MP0009745_abnormal_behavioral_response1.25595137
47MP0001968_abnormal_touch/_nociception1.24732010
48MP0005174_abnormal_tail_pigmentation1.24641619
49MP0000003_abnormal_adipose_tissue1.24556963
50MP0003763_abnormal_thymus_physiology1.23212704
51MP0003172_abnormal_lysosome_physiology1.20123353
52MP0005551_abnormal_eye_electrophysiolog1.14197189
53MP0009785_altered_susceptibility_to1.11342898
54MP0002148_abnormal_hypersensitivity_rea1.10520763
55MP0002735_abnormal_chemical_nociception1.10491826
56MP0003303_peritoneal_inflammation1.06354877
57MP0005670_abnormal_white_adipose1.03865768
58MP0001845_abnormal_inflammatory_respons1.02975046
59MP0010386_abnormal_urinary_bladder1.02802554
60MP0005025_abnormal_response_to1.02387192
61MP0005360_urolithiasis1.02004855
62MP0000689_abnormal_spleen_morphology1.01800333
63MP0002736_abnormal_nociception_after0.98863027
64MP0003950_abnormal_plasma_membrane0.96867114
65MP0000716_abnormal_immune_system0.95662309
66MP0002822_catalepsy0.95639954
67MP0003045_fibrosis0.95589192
68MP0004019_abnormal_vitamin_homeostasis0.94707672
69MP0005448_abnormal_energy_balance0.93568124
70MP0002909_abnormal_adrenal_gland0.93103979
71MP0005332_abnormal_amino_acid0.90940587
72MP0002928_abnormal_bile_duct0.90549172
73MP0000427_abnormal_hair_cycle0.90123129
74MP0001764_abnormal_homeostasis0.90064135
75MP0009840_abnormal_foam_cell0.89043864
76MP0002078_abnormal_glucose_homeostasis0.88427641
77MP0005220_abnormal_exocrine_pancreas0.88261672
78MP0008872_abnormal_physiological_respon0.88051147
79MP0002398_abnormal_bone_marrow0.84114189
80MP0010155_abnormal_intestine_physiology0.83759640
81MP0004145_abnormal_muscle_electrophysio0.83585838
82MP0001666_abnormal_nutrient_absorption0.81266877
83MP0004264_abnormal_extraembryonic_tissu0.81162591
84MP0005367_renal/urinary_system_phenotyp0.77324711
85MP0000516_abnormal_urinary_system0.77324711
86MP0008961_abnormal_basal_metabolism0.76720668
87MP0003879_abnormal_hair_cell0.72947545
88MP0002722_abnormal_immune_system0.72751338
89MP0003137_abnormal_impulse_conducting0.72397844
90MP0002638_abnormal_pupillary_reflex0.72145317
91MP0003718_maternal_effect0.71476890
92MP0004270_analgesia0.71233846
93MP0000538_abnormal_urinary_bladder0.70504884
94MP0002429_abnormal_blood_cell0.69559648
95MP0002419_abnormal_innate_immunity0.67924905
96MP0005647_abnormal_sex_gland0.67251006
97MP0000609_abnormal_liver_physiology0.66703448
98MP0004924_abnormal_behavior0.66470972
99MP0005386_behavior/neurological_phenoty0.66470972
100MP0005636_abnormal_mineral_homeostasis0.66456289

Predicted human phenotypes

RankGene SetZ-score
1Dysmetric saccades (HP:0000641)5.69640175
2Genetic anticipation (HP:0003743)5.40683628
3Progressive cerebellar ataxia (HP:0002073)5.32573114
4Prostate neoplasm (HP:0100787)4.84262148
5Severe visual impairment (HP:0001141)4.80483269
6Gastrointestinal stroma tumor (HP:0100723)4.64641663
7Gaze-evoked nystagmus (HP:0000640)4.17460350
8Pendular nystagmus (HP:0012043)4.17457239
9Action tremor (HP:0002345)4.16108897
10Agammaglobulinemia (HP:0004432)3.84671577
11Postural tremor (HP:0002174)3.41856578
12Recurrent sinusitis (HP:0011108)3.37987923
13IgA deficiency (HP:0002720)3.31070242
14Abnormality of the prostate (HP:0008775)3.30746788
15Chronic diarrhea (HP:0002028)3.23812983
16Pigmentary retinal degeneration (HP:0001146)3.02219022
17Increased density of long bones (HP:0006392)3.01746014
18Lymphopenia (HP:0001888)3.01562112
19Abnormality of cells of the lymphoid lineage (HP:0012140)2.91766466
20Hyperventilation (HP:0002883)2.81591661
21Recurrent bronchitis (HP:0002837)2.80361415
22Abnormality of T cell physiology (HP:0011840)2.71090384
23Abnormality of macular pigmentation (HP:0008002)2.68635974
24Proximal tubulopathy (HP:0000114)2.61909209
25Limb ataxia (HP:0002070)2.59633726
26Abnormality of the hepatic vasculature (HP:0006707)2.57848474
27Congenital stationary night blindness (HP:0007642)2.56530527
28Emphysema (HP:0002097)2.53128161
29Congenital malformation of the right heart (HP:0011723)2.50293922
30Double outlet right ventricle (HP:0001719)2.50293922
31Dialeptic seizures (HP:0011146)2.48184106
32Absence seizures (HP:0002121)2.44040280
33Impaired vibratory sensation (HP:0002495)2.42318742
34Congenital sensorineural hearing impairment (HP:0008527)2.40629018
35IgG deficiency (HP:0004315)2.39932016
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.39711624
37Vasculitis (HP:0002633)2.33628017
38Meningitis (HP:0001287)2.32416255
39Chronic otitis media (HP:0000389)2.31407041
40Hypoplasia of the uterus (HP:0000013)2.29371130
41Unilateral renal agenesis (HP:0000122)2.29361034
42Impaired smooth pursuit (HP:0007772)2.29306522
43IgM deficiency (HP:0002850)2.25335423
44Attenuation of retinal blood vessels (HP:0007843)2.22270501
45Type 2 muscle fiber atrophy (HP:0003554)2.21487463
46Abnormality of male internal genitalia (HP:0000022)2.18814267
47Abnormality of vitamin B metabolism (HP:0004340)2.18713263
48Postural instability (HP:0002172)2.17327648
49Bronchiectasis (HP:0002110)2.12878818
50Restrictive lung disease (HP:0002091)2.11042156
51Intestinal atresia (HP:0011100)2.07721835
52Slow saccadic eye movements (HP:0000514)2.04850898
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03589115
54Abnormality of urine glucose concentration (HP:0011016)2.01051929
55Glycosuria (HP:0003076)2.01051929
56Popliteal pterygium (HP:0009756)1.99015823
57Recurrent cutaneous fungal infections (HP:0011370)1.97482939
58Chronic mucocutaneous candidiasis (HP:0002728)1.97482939
59Late onset (HP:0003584)1.96991431
60Recurrent pneumonia (HP:0006532)1.95426285
61Inflammation of the large intestine (HP:0002037)1.92299092
62Chronic sinusitis (HP:0011109)1.90366533
63Hypoalbuminemia (HP:0003073)1.88772343
64Abnormal albumin level (HP:0012116)1.88772343
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.88241960
66Hypoplasia of the fovea (HP:0007750)1.88241960
67Retinitis pigmentosa (HP:0000510)1.84820346
68Hemiparesis (HP:0001269)1.84683700
69Dysdiadochokinesis (HP:0002075)1.83811790
70Muscle fiber atrophy (HP:0100295)1.82387315
71Bony spicule pigmentary retinopathy (HP:0007737)1.82256137
72Recurrent fungal infections (HP:0002841)1.82155307
73Abnormality of ocular smooth pursuit (HP:0000617)1.81542027
74Abnormality of the renal cortex (HP:0011035)1.80957594
75Clumsiness (HP:0002312)1.80834868
76Recurrent lower respiratory tract infections (HP:0002783)1.80219309
77Abnormal pancreas size (HP:0012094)1.77277521
78Increased CSF protein (HP:0002922)1.76944163
79Dry hair (HP:0011359)1.76325343
80Aplasia/hypoplasia of the uterus (HP:0008684)1.75692064
81Urinary bladder sphincter dysfunction (HP:0002839)1.75681962
82Bronchitis (HP:0012387)1.74993740
83Fatigable weakness (HP:0003473)1.74529084
84Abnormality of the neuromuscular junction (HP:0003398)1.74529084
85Recurrent bacterial skin infections (HP:0005406)1.73737509
86Recurrent viral infections (HP:0004429)1.73593609
87Ketoacidosis (HP:0001993)1.73396861
88Impaired proprioception (HP:0010831)1.72761572
89Osteomyelitis (HP:0002754)1.72082464
90Generalized aminoaciduria (HP:0002909)1.71756406
91Verrucae (HP:0200043)1.71382784
92Papilloma (HP:0012740)1.71382784
93Focal seizures (HP:0007359)1.71170687
94Hypothermia (HP:0002045)1.69747184
95Protruding tongue (HP:0010808)1.69314437
96Abnormal rod and cone electroretinograms (HP:0008323)1.69053033
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.68551894
98Absent/shortened dynein arms (HP:0200106)1.68551894
99Gastrointestinal inflammation (HP:0004386)1.68424877
100Large for gestational age (HP:0001520)1.68251438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.29883845
2CDK196.23905156
3OXSR13.70780166
4MAP4K23.24651508
5PRKD33.08396082
6MAP4K12.43461986
7RIPK42.34708545
8PINK12.32075158
9WNK32.23129046
10TNK22.07717607
11SIK21.96512298
12MST41.94887128
13GRK11.87307410
14DAPK21.80666253
15MUSK1.68444610
16ACVR1B1.61610923
17ADRBK21.49834588
18IKBKE1.42107556
19ZAK1.33140392
20FGFR31.30599268
21KIT1.28151261
22IKBKB1.16859215
23RPS6KB21.14697826
24TAOK31.12792320
25BMPR21.11159535
26MAPK131.05625808
27CSF1R1.05529573
28SYK1.05181577
29BMPR1B1.04976214
30PRKD21.04967513
31MAP3K71.01121254
32PRKCH1.00922722
33TAF11.00884669
34FGFR41.00796100
35JAK11.00497452
36BLK0.99819995
37MAP3K140.99659280
38TYK20.99192758
39IRAK40.91964578
40SMG10.91935645
41MARK30.90780273
42MAPK110.87800463
43INSRR0.80356107
44NEK90.79015174
45PRKCI0.76929641
46STK110.76851910
47PRKCQ0.74934525
48EEF2K0.74646288
49VRK10.74246199
50CHUK0.74046828
51TLK10.73275040
52EPHA30.72351456
53PDK10.71458481
54HIPK20.71368862
55STK40.70308917
56BTK0.68077408
57TBK10.68058216
58ERN10.65484891
59MAPKAPK30.63332602
60STK30.62569016
61CDK40.62320282
62LYN0.60879486
63DDR20.60367560
64EIF2AK30.59636814
65PRKAA20.58961670
66STK240.58419455
67MAPKAPK50.56810143
68YES10.56727236
69RPS6KA50.55454297
70PIM10.53717926
71MAP3K130.53610233
72MAP2K60.53168079
73CCNB10.53058545
74FER0.52349040
75FGFR20.52278199
76MATK0.50341255
77TRPM70.48922166
78PDPK10.48125645
79PRKCZ0.46247181
80CDK80.46115803
81CAMK1D0.45308439
82CDC42BPA0.44420723
83PAK30.43765504
84LIMK10.43316583
85SIK30.40041973
86PRKCE0.39732359
87PRPF4B0.38520345
88DAPK30.37142299
89TXK0.36736718
90UHMK10.36449037
91DAPK10.35345910
92MAP3K40.34785687
93JAK20.34535212
94PTK2B0.34487487
95VRK20.33919774
96PKN10.33848724
97ALK0.33580569
98STK38L0.32371547
99LCK0.32049528
100PRKG20.30244837

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.89283297
2Allograft rejection_Homo sapiens_hsa053304.35661525
3Type I diabetes mellitus_Homo sapiens_hsa049404.15110953
4Autoimmune thyroid disease_Homo sapiens_hsa053203.89294421
5Asthma_Homo sapiens_hsa053103.82016176
6Graft-versus-host disease_Homo sapiens_hsa053323.72883608
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.20149899
8Primary immunodeficiency_Homo sapiens_hsa053403.11092092
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.69418003
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11489062
11Butanoate metabolism_Homo sapiens_hsa006502.05480241
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99874787
13Viral myocarditis_Homo sapiens_hsa054161.99110015
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.88984368
15Antigen processing and presentation_Homo sapiens_hsa046121.88712719
16Systemic lupus erythematosus_Homo sapiens_hsa053221.71205963
17Ether lipid metabolism_Homo sapiens_hsa005651.69929477
18B cell receptor signaling pathway_Homo sapiens_hsa046621.51405594
19Tryptophan metabolism_Homo sapiens_hsa003801.41384100
20Staphylococcus aureus infection_Homo sapiens_hsa051501.36092608
21Herpes simplex infection_Homo sapiens_hsa051681.34014677
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33041290
23Influenza A_Homo sapiens_hsa051641.29281516
24Linoleic acid metabolism_Homo sapiens_hsa005911.20580158
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17544906
26Leishmaniasis_Homo sapiens_hsa051401.12004125
27Caffeine metabolism_Homo sapiens_hsa002321.11987645
28Rheumatoid arthritis_Homo sapiens_hsa053231.11397918
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10433765
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01302355
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.00658934
32Sphingolipid metabolism_Homo sapiens_hsa006001.00230049
33Fatty acid biosynthesis_Homo sapiens_hsa000610.99859008
34Renin-angiotensin system_Homo sapiens_hsa046140.97948425
35Steroid hormone biosynthesis_Homo sapiens_hsa001400.95343003
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91153662
37Vitamin digestion and absorption_Homo sapiens_hsa049770.90848193
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.88203963
39ABC transporters_Homo sapiens_hsa020100.84242244
40Retinol metabolism_Homo sapiens_hsa008300.83290165
41Insulin secretion_Homo sapiens_hsa049110.83150638
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82685492
43Propanoate metabolism_Homo sapiens_hsa006400.79438116
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74922555
45Fat digestion and absorption_Homo sapiens_hsa049750.74872834
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68671901
47Toxoplasmosis_Homo sapiens_hsa051450.67488604
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66877006
49Sulfur metabolism_Homo sapiens_hsa009200.66740319
50Measles_Homo sapiens_hsa051620.64991727
51Selenocompound metabolism_Homo sapiens_hsa004500.64375240
52Olfactory transduction_Homo sapiens_hsa047400.60767676
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60680751
54Tuberculosis_Homo sapiens_hsa051520.59359704
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57430632
56Hepatitis C_Homo sapiens_hsa051600.55261323
57Hematopoietic cell lineage_Homo sapiens_hsa046400.54600945
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54525914
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54176589
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.50139298
61Epstein-Barr virus infection_Homo sapiens_hsa051690.48909753
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.48716543
63Alcoholism_Homo sapiens_hsa050340.45855552
64Homologous recombination_Homo sapiens_hsa034400.45762564
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43364429
66Phototransduction_Homo sapiens_hsa047440.42375983
67Starch and sucrose metabolism_Homo sapiens_hsa005000.41686306
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.41514488
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40599979
70Arachidonic acid metabolism_Homo sapiens_hsa005900.39744029
71N-Glycan biosynthesis_Homo sapiens_hsa005100.39083087
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35676852
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35181838
74Purine metabolism_Homo sapiens_hsa002300.34377606
75Salivary secretion_Homo sapiens_hsa049700.34174585
76Chemokine signaling pathway_Homo sapiens_hsa040620.33137884
77Fatty acid degradation_Homo sapiens_hsa000710.32960571
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.30706725
79Glycerolipid metabolism_Homo sapiens_hsa005610.29999083
80Fatty acid metabolism_Homo sapiens_hsa012120.28604111
81Chemical carcinogenesis_Homo sapiens_hsa052040.28274845
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27811715
83Glucagon signaling pathway_Homo sapiens_hsa049220.26460450
84Long-term depression_Homo sapiens_hsa047300.25975258
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25177634
86RNA polymerase_Homo sapiens_hsa030200.24901261
87Viral carcinogenesis_Homo sapiens_hsa052030.24249498
88African trypanosomiasis_Homo sapiens_hsa051430.23501419
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.23115627
90Other glycan degradation_Homo sapiens_hsa005110.20365082
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19597804
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19487089
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19259308
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17267021
95Peroxisome_Homo sapiens_hsa041460.15396451
96Phagosome_Homo sapiens_hsa041450.14269028
97Serotonergic synapse_Homo sapiens_hsa047260.13522407
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13484382
99Collecting duct acid secretion_Homo sapiens_hsa049660.13343034
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13273385

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