FCGRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.33251270
2L-phenylalanine catabolic process (GO:0006559)5.33251270
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29079479
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.16319972
5L-phenylalanine metabolic process (GO:0006558)5.16319972
6complement activation, alternative pathway (GO:0006957)4.95618139
7aromatic amino acid family catabolic process (GO:0009074)4.92142460
8alpha-linolenic acid metabolic process (GO:0036109)4.85107462
9neutrophil activation involved in immune response (GO:0002283)4.69060864
10peptidyl-glutamic acid carboxylation (GO:0017187)4.62522115
11protein carboxylation (GO:0018214)4.62522115
12regulation of protein activation cascade (GO:2000257)4.60428931
13indole-containing compound catabolic process (GO:0042436)4.58903010
14indolalkylamine catabolic process (GO:0046218)4.58903010
15tryptophan catabolic process (GO:0006569)4.58903010
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58772230
17negative regulation of interleukin-12 production (GO:0032695)4.58469657
18response to peptidoglycan (GO:0032494)4.55667936
19sulfur amino acid catabolic process (GO:0000098)4.50513374
20glyoxylate metabolic process (GO:0046487)4.47864679
21regulation of complement activation (GO:0030449)4.47052749
22kynurenine metabolic process (GO:0070189)4.44357850
23high-density lipoprotein particle remodeling (GO:0034375)4.41041803
24tryptophan metabolic process (GO:0006568)4.37725854
25bile acid biosynthetic process (GO:0006699)4.31104871
26negative regulation of fibrinolysis (GO:0051918)4.26887465
27regulation of triglyceride catabolic process (GO:0010896)4.23912785
28plasma lipoprotein particle clearance (GO:0034381)4.21841615
29reverse cholesterol transport (GO:0043691)4.20592531
30macrophage activation involved in immune response (GO:0002281)4.16229787
31regulation of fibrinolysis (GO:0051917)4.11936459
32regulation of cholesterol esterification (GO:0010872)4.10917239
33urea cycle (GO:0000050)4.07486044
34urea metabolic process (GO:0019627)4.07486044
35homocysteine metabolic process (GO:0050667)4.01656511
36phospholipid efflux (GO:0033700)4.00728634
37lysine metabolic process (GO:0006553)3.99373302
38lysine catabolic process (GO:0006554)3.99373302
39immunoglobulin mediated immune response (GO:0016064)3.98421812
40acylglycerol homeostasis (GO:0055090)3.98012198
41triglyceride homeostasis (GO:0070328)3.98012198
42positive regulation by symbiont of host defense response (GO:0052509)3.96000830
43modulation by symbiont of host defense response (GO:0052031)3.96000830
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96000830
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96000830
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.96000830
47modulation by symbiont of host immune response (GO:0052553)3.96000830
48cysteine metabolic process (GO:0006534)3.94326583
49amino-acid betaine metabolic process (GO:0006577)3.92386368
50glycosphingolipid catabolic process (GO:0046479)3.92192986
51plasma lipoprotein particle remodeling (GO:0034369)3.84799868
52protein-lipid complex remodeling (GO:0034368)3.84799868
53macromolecular complex remodeling (GO:0034367)3.84799868
54detection of other organism (GO:0098543)3.78896239
55negative regulation of cell killing (GO:0031342)3.77977040
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77977040
57positive regulation of gamma-delta T cell activation (GO:0046645)3.77827909
58nitrogen cycle metabolic process (GO:0071941)3.77106226
59fatty acid beta-oxidation (GO:0006635)3.74170703
60serine family amino acid catabolic process (GO:0009071)3.72863680
61bile acid metabolic process (GO:0008206)3.70613234
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.65633848
63phospholipid homeostasis (GO:0055091)3.65455813
64fatty acid oxidation (GO:0019395)3.61091653
65positive regulation of triglyceride lipase activity (GO:0061365)3.60155273
66positive regulation of lipoprotein lipase activity (GO:0051006)3.60155273
67detection of bacterium (GO:0016045)3.58462015
68low-density lipoprotein particle clearance (GO:0034383)3.58047913
69lipid oxidation (GO:0034440)3.56436492
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56169149
71glycolipid catabolic process (GO:0019377)3.55843517
72regulation of mast cell degranulation (GO:0043304)3.55024340
73regulation of mononuclear cell migration (GO:0071675)3.54855782
74detection of molecule of bacterial origin (GO:0032490)3.54738958
75valine metabolic process (GO:0006573)3.54612539
76oligosaccharide catabolic process (GO:0009313)3.54506729
77aromatic amino acid family metabolic process (GO:0009072)3.52391657
78cellular ketone body metabolic process (GO:0046950)3.49774345
79detection of external biotic stimulus (GO:0098581)3.48458006
80positive regulation of lipid catabolic process (GO:0050996)3.47744684
81cellular response to thyroid hormone stimulus (GO:0097067)3.46698478
82complement activation (GO:0006956)3.45301415
83tyrosine metabolic process (GO:0006570)3.45032713
84fatty acid catabolic process (GO:0009062)3.44765881
85alpha-amino acid catabolic process (GO:1901606)3.43075937
86negative regulation of cholesterol transport (GO:0032375)3.40310728
87negative regulation of sterol transport (GO:0032372)3.40310728
88regulation of cholesterol storage (GO:0010885)3.40247068
89cholesterol efflux (GO:0033344)3.39989057
90regulation of sequestering of triglyceride (GO:0010889)3.37752021
91regulation of cholesterol homeostasis (GO:2000188)3.37447575
92positive regulation of fatty acid oxidation (GO:0046321)3.36134486
93lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35515992
94protein activation cascade (GO:0072376)3.35045709
95plasma lipoprotein particle assembly (GO:0034377)3.34839147
96negative regulation of lipase activity (GO:0060192)3.33802573
97fibrinolysis (GO:0042730)3.33674923
98negative regulation of erythrocyte differentiation (GO:0045647)3.32968585
99monocarboxylic acid catabolic process (GO:0072329)3.32028890
100amino sugar catabolic process (GO:0046348)3.31535569
101short-chain fatty acid metabolic process (GO:0046459)3.30958766
102T-helper 1 type immune response (GO:0042088)3.29582703
103ethanol oxidation (GO:0006069)3.28728361
104carnitine metabolic process (GO:0009437)3.27267350
105drug catabolic process (GO:0042737)3.27215206
106bile acid and bile salt transport (GO:0015721)3.25817760
107cellular amino acid catabolic process (GO:0009063)3.25544331
108complement activation, classical pathway (GO:0006958)3.25163023
109antigen processing and presentation of endogenous antigen (GO:0019883)3.25044974
110low-density lipoprotein particle remodeling (GO:0034374)3.23964594
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23794024
112regulation of mast cell activation involved in immune response (GO:0033006)3.23297897
113cholesterol homeostasis (GO:0042632)3.22874446
114fatty acid transmembrane transport (GO:1902001)3.21785232
1152-oxoglutarate metabolic process (GO:0006103)3.21317504
116positive regulation of mast cell degranulation (GO:0043306)3.19641366
117positive regulation of mast cell activation involved in immune response (GO:0033008)3.19641366
118regulation of leukocyte degranulation (GO:0043300)3.19341117
119acetyl-CoA metabolic process (GO:0006084)3.19197103
120cellular modified amino acid catabolic process (GO:0042219)3.18940892
121lipoprotein metabolic process (GO:0042157)3.18923931
122sterol homeostasis (GO:0055092)3.18905615
123granulocyte activation (GO:0036230)3.18693629
124indolalkylamine metabolic process (GO:0006586)3.18674882
125amine catabolic process (GO:0009310)3.17570875
126cellular biogenic amine catabolic process (GO:0042402)3.17570875
127benzene-containing compound metabolic process (GO:0042537)3.17243682
128carboxylic acid catabolic process (GO:0046395)3.15963022
129organic acid catabolic process (GO:0016054)3.15963022
130positive regulation of triglyceride metabolic process (GO:0090208)3.14226925
131interferon-gamma-mediated signaling pathway (GO:0060333)3.13957953
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.13713379
133urate metabolic process (GO:0046415)3.13354442
134regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13197565
135positive regulation of mast cell activation (GO:0033005)3.12521560
136drug transmembrane transport (GO:0006855)3.12100482
137macrophage activation (GO:0042116)3.11186789
138regulation of interferon-beta biosynthetic process (GO:0045357)3.10187414
139opsonization (GO:0008228)3.10013872
140cellular glucuronidation (GO:0052695)3.09534974
141negative regulation of cytokine production involved in immune response (GO:0002719)3.08635412
142plasma lipoprotein particle organization (GO:0071827)3.07505500
143ceramide catabolic process (GO:0046514)3.07074152
144positive regulation of leukocyte degranulation (GO:0043302)3.06347664
145detection of biotic stimulus (GO:0009595)3.05342482
146positive regulation of antigen processing and presentation (GO:0002579)3.03592648
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00560452
148regulation of antigen processing and presentation (GO:0002577)2.98809781
149myeloid dendritic cell differentiation (GO:0043011)2.97477641
150positive regulation of cellular amide metabolic process (GO:0034250)2.96950295
151NIK/NF-kappaB signaling (GO:0038061)2.95955917
152neutrophil activation (GO:0042119)2.95367153
153regulation of macrophage chemotaxis (GO:0010758)2.95252677
154positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93548598
155N-acetylneuraminate metabolic process (GO:0006054)2.91637895
156germinal center formation (GO:0002467)2.90099797
157barbed-end actin filament capping (GO:0051016)2.89837980
158angiotensin maturation (GO:0002003)2.87624558
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87471786
160myeloid cell activation involved in immune response (GO:0002275)2.87127148
161adhesion of symbiont to host cell (GO:0044650)2.86580393
162virion attachment to host cell (GO:0019062)2.86580393
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86502298
164negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83944480
165regulation of mast cell activation (GO:0033003)2.82050936
166B cell mediated immunity (GO:0019724)2.81917009
167cellular response to type I interferon (GO:0071357)2.81250711
168type I interferon signaling pathway (GO:0060337)2.81250711
169microglial cell activation (GO:0001774)2.79792707
170positive regulation of chemokine biosynthetic process (GO:0045080)2.78541386
171response to type I interferon (GO:0034340)2.78173808
172cellular extravasation (GO:0045123)2.78005804
173response to muramyl dipeptide (GO:0032495)2.77685850
174positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77642857
175positive regulation of monocyte chemotaxis (GO:0090026)2.77002369
176regulation of T-helper 2 cell differentiation (GO:0045628)2.76707433
177myeloid dendritic cell activation (GO:0001773)2.75388091
178response to thyroid hormone (GO:0097066)2.75154181
179regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74292510
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74094658
181mannose metabolic process (GO:0006013)2.73207039
182respiratory burst (GO:0045730)2.72223798
183regulation of podosome assembly (GO:0071801)2.71121410
184regulation of cytokine secretion involved in immune response (GO:0002739)2.71119320
185regulation of gamma-delta T cell activation (GO:0046643)2.70840583
186defense response to protozoan (GO:0042832)2.68389769
187regulation of T cell tolerance induction (GO:0002664)2.67836470
188membrane lipid catabolic process (GO:0046466)2.67061529
189hydrogen peroxide biosynthetic process (GO:0050665)2.62444847
190sphingolipid catabolic process (GO:0030149)2.61973911
191negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61382650
192regulation of monocyte chemotaxis (GO:0090025)2.59195417
193regulation of interferon-alpha production (GO:0032647)2.57226673
194pinocytosis (GO:0006907)2.56867854
195response to protozoan (GO:0001562)2.56507571
196response to host immune response (GO:0052572)2.56250232
197response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56250232
198regulation of chemokine biosynthetic process (GO:0045073)2.55420393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.82441949
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.47121415
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.37433177
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47625404
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.15110603
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.72918771
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.05170617
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44511106
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18777696
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.79600152
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.67260993
12* CLOCK_20551151_ChIP-Seq_293T_Human2.67114621
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64153288
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.49362523
15VDR_21846776_ChIP-Seq_THP-1_Human2.48805704
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41723667
17VDR_24763502_ChIP-Seq_THP-1_Human2.40765033
18SPI1_23127762_ChIP-Seq_K562_Human2.12681106
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.07241787
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04550328
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91124591
22SPI1_23547873_ChIP-Seq_NB4_Human1.88398002
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86939902
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85843035
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85785786
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84830941
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82966140
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.73798386
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73760845
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73062844
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70460038
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70058816
33SCL_19346495_ChIP-Seq_HPC-7_Human1.69758481
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69567151
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66565919
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66513249
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63907652
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.58492701
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.58200454
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54535693
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54422323
42GATA1_22025678_ChIP-Seq_K562_Human1.53794387
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51309586
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51079323
45MAF_26560356_Chip-Seq_TH1_Human1.49673540
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48063719
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45955338
48TCF7_22412390_ChIP-Seq_EML_Mouse1.45891029
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45783849
50* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41231619
51RUNX_20019798_ChIP-Seq_JUKART_Human1.40959234
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.39021712
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38797424
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38794935
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.38271930
56KDM2B_26808549_Chip-Seq_DND41_Human1.36886269
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36826326
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36425031
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.31399923
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.31302725
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31256389
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29024838
63UTX_26944678_Chip-Seq_JUKART_Human1.27899737
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27662114
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26391112
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24869062
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.22270812
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21906670
69BCL6_27268052_Chip-Seq_Bcells_Human1.21790868
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21652022
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19475738
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18706244
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.18106227
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18068908
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16723584
76BCOR_27268052_Chip-Seq_Bcells_Human1.16097521
77MYC_22102868_ChIP-Seq_BL_Human1.16080632
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16019951
79PU_27001747_Chip-Seq_BMDM_Mouse1.14796924
80* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14171970
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10632871
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.08059910
83MAF_26560356_Chip-Seq_TH2_Human1.07663872
84MYB_26560356_Chip-Seq_TH2_Human1.07265326
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07188127
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07169695
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07159374
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05878039
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05878039
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05033407
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.03054593
92STAT1_20625510_ChIP-Seq_HELA_Human1.00917873
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99312331
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.99143978
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99003405
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97019968
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96810890
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96488397
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96045224
100MYB_26560356_Chip-Seq_TH1_Human0.94784103
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.93327996
102KDM2B_26808549_Chip-Seq_K562_Human0.93098127
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.92369337
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92362998
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92329868
106CJUN_26792858_Chip-Seq_BT549_Human0.92287208
107SOX2_20726797_ChIP-Seq_SW620_Human0.91684537
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91618009
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91608379
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90879992
111LXR_22292898_ChIP-Seq_THP-1_Human0.90728353
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.90249370
113GATA1_19941826_ChIP-Seq_K562_Human0.87973143
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85542088
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85024072
116* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84533801
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.82229222
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.82229222
119GATA4_25053715_ChIP-Seq_YYC3_Human0.81960663
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80565287
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77873514
122VDR_24787735_ChIP-Seq_THP-1_Human0.76438679
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.75720980
124GATA2_19941826_ChIP-Seq_K562_Human0.75678775
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74977661
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72675155
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72081758
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71268135
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71185897
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70824230
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70440071
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70411604
133HTT_18923047_ChIP-ChIP_STHdh_Human0.67911648
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67847224
135EGR1_19032775_ChIP-ChIP_M12_Human0.67549842
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66773642
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65951941
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64937873
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63917078
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.62242304
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.61655484
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.60936977
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60835042
144* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60476199
145RACK7_27058665_Chip-Seq_MCF-7_Human0.60443670
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60359898
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60095479
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59404738
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57803429
150CEBPB_22108803_ChIP-Seq_LS180_Human0.56465418
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.54981239
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.54342960
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.54292860
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54016797
155SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53683988
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52870511
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52596178
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52551114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.17731536
2MP0005360_urolithiasis5.52745529
3MP0005365_abnormal_bile_salt4.51111997
4MP0005085_abnormal_gallbladder_physiolo4.22540198
5MP0003303_peritoneal_inflammation4.15566169
6MP0008875_abnormal_xenobiotic_pharmacok3.49181604
7MP0003191_abnormal_cellular_cholesterol3.24306117
8MP0010329_abnormal_lipoprotein_level3.20195025
9MP0009840_abnormal_foam_cell3.15539294
10MP0003252_abnormal_bile_duct2.86860977
11MP0008438_abnormal_cutaneous_collagen2.81052104
12MP0002148_abnormal_hypersensitivity_rea2.70929101
13MP0010368_abnormal_lymphatic_system2.67722364
14MP0005670_abnormal_white_adipose2.67597715
15MP0003172_abnormal_lysosome_physiology2.52879545
16MP0005025_abnormal_response_to2.42566697
17MP0003806_abnormal_nucleotide_metabolis2.38333364
18MP0005387_immune_system_phenotype2.35285881
19MP0001790_abnormal_immune_system2.35285881
20MP0005332_abnormal_amino_acid2.33262620
21MP0005000_abnormal_immune_tolerance2.31382819
22MP0003724_increased_susceptibility_to2.28731152
23MP0005671_abnormal_response_to2.20345190
24MP0004019_abnormal_vitamin_homeostasis2.18989450
25MP0004510_myositis2.10258225
26MP0000685_abnormal_immune_system2.06612956
27* MP0002452_abnormal_antigen_presenting1.94655076
28MP0000609_abnormal_liver_physiology1.91640382
29MP0003705_abnormal_hypodermis_morpholog1.90138429
30* MP0002723_abnormal_immune_serum1.88949465
31MP0003195_calcinosis1.88575551
32MP0002118_abnormal_lipid_homeostasis1.86812922
33MP0005083_abnormal_biliary_tract1.83985721
34* MP0001800_abnormal_humoral_immune1.83605991
35MP0002138_abnormal_hepatobiliary_system1.81654236
36MP0009278_abnormal_bone_marrow1.80249472
37MP0010155_abnormal_intestine_physiology1.77203723
38MP0001666_abnormal_nutrient_absorption1.75802861
39MP0005319_abnormal_enzyme/_coenzyme1.69546574
40* MP0002420_abnormal_adaptive_immunity1.67551365
41* MP0001819_abnormal_immune_cell1.67445175
42MP0004130_abnormal_muscle_cell1.67202268
43MP0005275_abnormal_skin_tensile1.63236547
44MP0005058_abnormal_lysosome_morphology1.59120053
45MP0001879_abnormal_lymphatic_vessel1.57186626
46MP0002405_respiratory_system_inflammati1.54902741
47MP0005397_hematopoietic_system_phenotyp1.49883022
48MP0001545_abnormal_hematopoietic_system1.49883022
49MP0004947_skin_inflammation1.49643143
50MP0002254_reproductive_system_inflammat1.46223943
51MP0009643_abnormal_urine_homeostasis1.43349031
52MP0005166_decreased_susceptibility_to1.43127509
53MP0005666_abnormal_adipose_tissue1.42947258
54MP0003183_abnormal_peptide_metabolism1.40292983
55MP0005584_abnormal_enzyme/coenzyme_acti1.40086226
56MP0000858_altered_metastatic_potential1.39999262
57MP0003186_abnormal_redox_activity1.34729315
58MP0005310_abnormal_salivary_gland1.28723311
59MP0009333_abnormal_splenocyte_physiolog1.28477024
60MP0008260_abnormal_autophagy1.28326792
61MP0009764_decreased_sensitivity_to1.27901282
62MP0006054_spinal_hemorrhage1.27583018
63MP0003448_altered_tumor_morphology1.25670564
64MP0005167_abnormal_blood-brain_barrier1.24591733
65MP0003690_abnormal_glial_cell1.24318688
66MP0003279_aneurysm1.20008436
67MP0003329_amyloid_beta_deposits1.19264602
68MP0000604_amyloidosis1.17840781
69MP0004272_abnormal_basement_membrane1.17836480
70MP0003011_delayed_dark_adaptation1.17724307
71MP0001764_abnormal_homeostasis1.16758256
72MP0000716_abnormal_immune_system1.15841297
73MP0000465_gastrointestinal_hemorrhage1.09439274
74MP0003453_abnormal_keratinocyte_physiol1.08626930
75* MP0008469_abnormal_protein_level1.08190703
76MP0009763_increased_sensitivity_to1.07106525
77MP0003436_decreased_susceptibility_to1.05749293
78MP0000343_altered_response_to1.04425803
79MP0002971_abnormal_brown_adipose1.02809279
80MP0000598_abnormal_liver_morphology1.02531911
81MP0000013_abnormal_adipose_tissue1.01975611
82MP0005390_skeleton_phenotype0.98526521
83MP0001663_abnormal_digestive_system0.98521900
84MP0005451_abnormal_body_composition0.98514079
85MP0002837_dystrophic_cardiac_calcinosis0.97503284
86MP0003300_gastrointestinal_ulcer0.95187402
87MP0001533_abnormal_skeleton_physiology0.92808540
88MP0005334_abnormal_fat_pad0.92767209
89MP0005375_adipose_tissue_phenotype0.92042874
90MP0002876_abnormal_thyroid_physiology0.91854234
91MP0001756_abnormal_urination0.91743878
92MP0009697_abnormal_copulation0.91017991
93MP0002398_abnormal_bone_marrow0.90528600
94MP0005164_abnormal_response_to0.89709716
95MP0000249_abnormal_blood_vessel0.89575855
96MP0005503_abnormal_tendon_morphology0.89202612
97MP0000689_abnormal_spleen_morphology0.89075884
98MP0001853_heart_inflammation0.88851539
99MP0000920_abnormal_myelination0.88135010
100MP0002429_abnormal_blood_cell0.87918042
101MP0003075_altered_response_to0.87383074
102MP0001835_abnormal_antigen_presentation0.86812039
103MP0009115_abnormal_fat_cell0.86658101
104MP0002933_joint_inflammation0.86621085
105MP0001958_emphysema0.86204054
106MP0002295_abnormal_pulmonary_circulatio0.85573615
107MP0004185_abnormal_adipocyte_glucose0.85052137
108MP0005647_abnormal_sex_gland0.84845381
109MP0005636_abnormal_mineral_homeostasis0.84445856
110MP0002136_abnormal_kidney_physiology0.84144024
111MP0002419_abnormal_innate_immunity0.82797526
112MP0002060_abnormal_skin_morphology0.81619364
113MP0001851_eye_inflammation0.81188029
114MP0003866_abnormal_defecation0.80640298
115MP0002277_abnormal_respiratory_mucosa0.79433394
116MP0003795_abnormal_bone_structure0.79109405
117MP0004883_abnormal_blood_vessel0.79003714
118* MP0009642_abnormal_blood_homeostasis0.77935088
119MP0001661_extended_life_span0.77503301
120MP0002722_abnormal_immune_system0.77361637
121MP0008004_abnormal_stomach_pH0.76297941
122MP0005464_abnormal_platelet_physiology0.74714441
123MP0005084_abnormal_gallbladder_morpholo0.72569797
124MP0005165_increased_susceptibility_to0.72121133
125MP0001542_abnormal_bone_strength0.71254699
126MP0003091_abnormal_cell_migration0.70423154
127MP0004782_abnormal_surfactant_physiolog0.69758051
128MP0000230_abnormal_systemic_arterial0.69474382
129MP0005376_homeostasis/metabolism_phenot0.69194905
130MP0003868_abnormal_feces_composition0.68117198
131MP0005595_abnormal_vascular_smooth0.67476254
132MP0000490_abnormal_crypts_of0.67217093
133MP0002998_abnormal_bone_remodeling0.66894017
134MP0004858_abnormal_nervous_system0.66636355
135MP0005535_abnormal_body_temperature0.66389307
136MP0005381_digestive/alimentary_phenotyp0.65227477
137MP0003656_abnormal_erythrocyte_physiolo0.64752759
138MP0003879_abnormal_hair_cell0.64750592
139MP0000767_abnormal_smooth_muscle0.64712706
140MP0006082_CNS_inflammation0.63558390
141MP0002332_abnormal_exercise_endurance0.63179940
142MP0009384_cardiac_valve_regurgitation0.63081774
143MP0002078_abnormal_glucose_homeostasis0.62900203
144MP0009785_altered_susceptibility_to0.62290792
145MP0002132_abnormal_respiratory_system0.62094204
146MP0001873_stomach_inflammation0.62061934
147MP0003828_pulmonary_edema0.61173597
148MP0001243_abnormal_dermal_layer0.61135939
149MP0001845_abnormal_inflammatory_respons0.60020136
150MP0005023_abnormal_wound_healing0.59099217
151MP0003566_abnormal_cell_adhesion0.58712995
152MP0002168_other_aberrant_phenotype0.57943071

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.45826977
2Abnormality of liposaccharide metabolism (HP:0010968)6.45826977
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.45826977
4Deep venous thrombosis (HP:0002625)5.71372422
5Complement deficiency (HP:0004431)5.64236457
6Xanthomatosis (HP:0000991)5.21406728
7Systemic lupus erythematosus (HP:0002725)4.95860755
8Abnormality of macrophages (HP:0004311)4.85782822
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.79530021
10Intrahepatic cholestasis (HP:0001406)4.78880221
11Eczematoid dermatitis (HP:0000976)4.76845912
12Prolonged partial thromboplastin time (HP:0003645)4.74717507
13Increased cerebral lipofuscin (HP:0011813)4.73901671
14Abnormality of complement system (HP:0005339)4.52052162
15Recurrent abscess formation (HP:0002722)4.45415023
16Abnormality of monocarboxylic acid metabolism (HP:0010996)4.44556019
17Recurrent bacterial skin infections (HP:0005406)4.31254181
18Joint hemorrhage (HP:0005261)4.24115031
19Hyperlipoproteinemia (HP:0010980)4.17654446
20Hyperglycinuria (HP:0003108)4.16427891
21Hypoalphalipoproteinemia (HP:0003233)4.03984606
22Loss of speech (HP:0002371)3.96368446
23Disinhibition (HP:0000734)3.92744826
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.85421069
25Hyperammonemia (HP:0001987)3.84217980
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80270869
27Hypobetalipoproteinemia (HP:0003563)3.75431342
28Myositis (HP:0100614)3.74850768
29Abnormality of serine family amino acid metabolism (HP:0010894)3.70144193
30Abnormality of glycine metabolism (HP:0010895)3.70144193
31Orchitis (HP:0100796)3.69506609
32Abnormality of fatty-acid metabolism (HP:0004359)3.68636151
33Hypolipoproteinemia (HP:0010981)3.68204342
34Glomerulonephritis (HP:0000099)3.61754056
35Hypoglycemic coma (HP:0001325)3.59064649
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.55740773
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.55740773
38Abnormality of polysaccharide metabolism (HP:0011012)3.55740773
39Ketosis (HP:0001946)3.54653409
40Abnormality of the common coagulation pathway (HP:0010990)3.50854347
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.46241611
42Hyperglycinemia (HP:0002154)3.42592479
43Mucopolysacchariduria (HP:0008155)3.40229033
44Urinary glycosaminoglycan excretion (HP:0003541)3.40229033
45Epidermoid cyst (HP:0200040)3.38511910
46Mediastinal lymphadenopathy (HP:0100721)3.30246658
47Mutism (HP:0002300)3.27721592
48Retrobulbar optic neuritis (HP:0100654)3.24249455
49Optic neuritis (HP:0100653)3.24249455
50Myocardial infarction (HP:0001658)3.22327401
51Stomatitis (HP:0010280)3.05709233
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04765658
53Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04430820
54Abnormality of sulfur amino acid metabolism (HP:0004339)3.04164266
55Neurofibrillary tangles (HP:0002185)3.04017995
56Obstructive lung disease (HP:0006536)3.01213512
57Chronic obstructive pulmonary disease (HP:0006510)3.01213512
58Abnormality of the intrinsic pathway (HP:0010989)3.00862865
59Nonimmune hydrops fetalis (HP:0001790)2.98701778
60Hypercholesterolemia (HP:0003124)2.97548075
61Ketoacidosis (HP:0001993)2.91330032
62Nuclear cataract (HP:0100018)2.82490559
63Gingivitis (HP:0000230)2.79453850
64Fat malabsorption (HP:0002630)2.75019308
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74734996
66Dicarboxylic aciduria (HP:0003215)2.74734996
67Abnormality of purine metabolism (HP:0004352)2.74610756
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.72242525
69Abnormality of methionine metabolism (HP:0010901)2.70978940
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70577126
71Autoimmune thrombocytopenia (HP:0001973)2.69213855
72Nephritis (HP:0000123)2.67899239
73Recurrent gram-negative bacterial infections (HP:0005420)2.63651403
74Increased serum ferritin (HP:0003281)2.62000000
75Amyloidosis (HP:0011034)2.61723849
76Skin nodule (HP:0200036)2.60415152
77Elevated erythrocyte sedimentation rate (HP:0003565)2.58452989
78Abnormality of nucleobase metabolism (HP:0010932)2.57884125
79Generalized aminoaciduria (HP:0002909)2.57394523
80Vascular calcification (HP:0004934)2.54434761
81Petechiae (HP:0000967)2.51831505
82Hydroxyprolinuria (HP:0003080)2.51599497
83Abnormality of proline metabolism (HP:0010907)2.51599497
84Cardiovascular calcification (HP:0011915)2.50901674
85Recurrent skin infections (HP:0001581)2.50822252
86Pulmonary infiltrates (HP:0002113)2.50575469
87Hematochezia (HP:0002573)2.48477236
88Esophageal varix (HP:0002040)2.47117996
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40062778
90Conjugated hyperbilirubinemia (HP:0002908)2.38360270
91Mitral stenosis (HP:0001718)2.37589483
92Hepatosplenomegaly (HP:0001433)2.37424692
93Upper motor neuron abnormality (HP:0002127)2.37036253
94Hepatocellular carcinoma (HP:0001402)2.36329081
95Hypertriglyceridemia (HP:0002155)2.35558954
96Progressive neurologic deterioration (HP:0002344)2.34764462
97Broad metatarsal (HP:0001783)2.34265114
98Hemorrhage of the eye (HP:0011885)2.33418928
99Meningitis (HP:0001287)2.32368253
100Delayed CNS myelination (HP:0002188)2.32285927
101Vacuolated lymphocytes (HP:0001922)2.30275832
102Keratoconjunctivitis sicca (HP:0001097)2.29618082
103Hemoptysis (HP:0002105)2.29502983
104Hyperbilirubinemia (HP:0002904)2.28352908
105Axonal loss (HP:0003447)2.27289821
106Metabolic acidosis (HP:0001942)2.27162551
107Recurrent fungal infections (HP:0002841)2.25669702
108Vasculitis (HP:0002633)2.24806110
109Abnormality of serum amino acid levels (HP:0003112)2.24487867
110Abnormality of pyrimidine metabolism (HP:0004353)2.24430864
111Neuronal loss in central nervous system (HP:0002529)2.21788629
112Nausea (HP:0002018)2.17775730
113Asymmetric septal hypertrophy (HP:0001670)2.17218899
114Urticaria (HP:0001025)2.16766542
115Gout (HP:0001997)2.16378935
116Pathologic fracture (HP:0002756)2.16108438
117Cerebral inclusion bodies (HP:0100314)2.13602874
118Proximal tubulopathy (HP:0000114)2.11391175
119Apathy (HP:0000741)2.10591425
120Pancreatitis (HP:0001733)2.09259227
121Diminished motivation (HP:0000745)2.09145992
122Spontaneous hematomas (HP:0007420)2.08645707
123Keratoconjunctivitis (HP:0001096)2.05871730
124Lethargy (HP:0001254)2.05231998
125Steatorrhea (HP:0002570)2.05087272
126Cellulitis (HP:0100658)2.04248582
127Pulmonary embolism (HP:0002204)2.03794377
128Protrusio acetabuli (HP:0003179)2.02935987
129Polycythemia (HP:0001901)2.01966963
130Increased IgE level (HP:0003212)2.01788057
131Premature rupture of membranes (HP:0001788)2.01503952
132Gastrointestinal infarctions (HP:0005244)2.01207742
133Peripheral demyelination (HP:0011096)2.00454439
134Peritonitis (HP:0002586)1.99551741
135Abnormal cartilage morphology (HP:0002763)1.99540460
136Hypoglycemic seizures (HP:0002173)1.98675598
137Agnosia (HP:0010524)1.98562895
138Inappropriate behavior (HP:0000719)1.98514281
139Increased purine levels (HP:0004368)1.98390307
140Hyperuricemia (HP:0002149)1.98390307
141Dementia (HP:0000726)1.97956963
142Vertebral compression fractures (HP:0002953)1.97781253
143Lymphangioma (HP:0100764)1.95594833
144Spontaneous abortion (HP:0005268)1.95238642
145Polyneuropathy (HP:0001271)1.94769690
146Epistaxis (HP:0000421)1.94487643
147Abnormality of the nasal mucosa (HP:0000433)1.93671326
148Personality changes (HP:0000751)1.92500197
149Basal ganglia calcification (HP:0002135)1.91638247
150Encephalitis (HP:0002383)1.90700739
151Vomiting (HP:0002013)1.90625193
152Sensorimotor neuropathy (HP:0007141)1.90525990
153Pustule (HP:0200039)1.90404830
154Increased CSF protein (HP:0002922)1.89567830
155Interstitial pulmonary disease (HP:0006530)1.86699279
156Thrombophlebitis (HP:0004418)1.86554497
157Prolonged neonatal jaundice (HP:0006579)1.86251432
158Retinal atrophy (HP:0001105)1.85429023
159Bone pain (HP:0002653)1.85165361
160Thoracic kyphosis (HP:0002942)1.83584553
161Abnormality of iron homeostasis (HP:0011031)1.83287671
162Malnutrition (HP:0004395)1.81479430
163Gingival bleeding (HP:0000225)1.80669688
164Restrictive lung disease (HP:0002091)1.80226124
165Alkalosis (HP:0001948)1.78781838
166Purpura (HP:0000979)1.78229572
167Enlarged kidneys (HP:0000105)1.76882769
168Conjunctival telangiectasia (HP:0000524)1.76809776
169Myoglobinuria (HP:0002913)1.76736427
170Episodic fever (HP:0001954)1.74424641
171Acrocyanosis (HP:0001063)1.74358405
172Acanthosis nigricans (HP:0000956)1.71954308
173Spastic diplegia (HP:0001264)1.71390563
174Irritability (HP:0000737)1.71296061
175Late onset (HP:0003584)1.71070254
176Neonatal onset (HP:0003623)1.71056612
177Dysostosis multiplex (HP:0000943)1.70869624
178Oligomenorrhea (HP:0000876)1.70728195
179Abnormality of transition element cation homeostasis (HP:0011030)1.69994201
180Menorrhagia (HP:0000132)1.68334409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.83255564
2TIE14.82465389
3BCKDK4.11214396
4ERN13.88258340
5TGFBR23.62066363
6RIPK43.11684055
7SIK12.79217439
8FGFR42.65384843
9TRIB32.45486670
10NME22.38402863
11BLK2.26657859
12CAMK1D2.21533246
13PRPF4B2.13643932
14TYK21.95595085
15TAOK11.92867105
16TAOK21.89001486
17FGR1.85050085
18MATK1.81958072
19NEK91.76827687
20INSRR1.76252943
21MST1R1.72246907
22JAK11.65177423
23PKN21.61413658
24FES1.59352353
25ACVR1B1.54913564
26TAOK31.52377347
27IRAK31.49877655
28EPHB11.48138152
29MYLK1.45687183
30MAP3K11.34038114
31MAP2K31.31803586
32RIPK11.31513137
33CAMK1G1.30398375
34FLT31.29105989
35TTN1.28557717
36CDC42BPA1.28381103
37TNK21.27920659
38PTK61.27740564
39TBK11.25813665
40TESK21.25470334
41JAK21.21822632
42SYK1.18485419
43MAP3K141.17722793
44MAP3K131.17722679
45MAP3K31.12437925
46EPHA31.12058530
47PRKAA21.10930152
48PIK3CG1.06769527
49BTK1.06353934
50HCK1.05200703
51EPHB21.04527877
52GRK11.02874044
53PIM21.02148584
54TESK11.02064070
55TXK1.00670520
56PDK20.95015380
57CSK0.92846876
58MAPK120.92787020
59PDGFRA0.92401507
60CAMKK20.90752472
61MAPK110.89927793
62MET0.89547514
63KIT0.87927411
64LCK0.85984543
65BMPR20.83582980
66GRK60.83193245
67JAK30.82669602
68FRK0.80715785
69ABL20.79375346
70TGFBR10.74819534
71LMTK20.74706115
72FGFR30.74374714
73SIK30.72570549
74MARK30.72253018
75GRK70.71736119
76CSF1R0.71397488
77MAP2K60.71009072
78PINK10.70282327
79IRAK20.69761943
80MAP4K10.69206071
81IKBKB0.69082685
82PIK3CA0.65528226
83CAMK40.65197083
84MAPK150.64979981
85PAK40.63708673
86PTK2B0.63630995
87IKBKE0.63565238
88MAP2K20.62695270
89RPS6KC10.62683609
90RPS6KL10.62683609
91FGFR20.62667111
92DAPK20.62012780
93MARK20.62008260
94MAPK70.61967873
95MAPK40.61897488
96MAP3K50.60571230
97PDK10.60133614
98PRKD20.59810099
99BMX0.58332905
100MAP2K10.56915472
101GSK3A0.56449122
102CHUK0.56225415
103CDK60.56084478
104PDK30.55395215
105PDK40.55395215
106IGF1R0.53637696
107LATS10.53519108
108TEC0.53228892
109FER0.53193844
110IRAK40.52742334
111ERBB40.52714974
112DYRK1B0.51086907
113ZAP700.50929728
114PRKG20.49779162
115ADRBK20.49328717
116RPS6KA60.49158002
117RPS6KA20.48915129
118ITK0.48765508
119STK38L0.48684515
120MUSK0.47682884
121DDR20.47366839
122KSR20.46593497
123MAP3K100.46255095
124IRAK10.45602686
125MAP3K60.45461084
126MAP3K70.45057276
127FYN0.44860279
128PRKAA10.43494598
129PTK20.42719807
130PRKACG0.42122358
131ICK0.40099459
132MAP2K40.39774218
133HIPK20.38831573
134PDPK10.38340339
135PRKD10.37377528
136CDK90.36259816
137LRRK20.35839809
138ARAF0.35266141
139PAK20.34889249
140PIM10.34148343
141SGK30.34131366
142ABL10.34102390
143LYN0.33380092
144MOS0.33208142
145SIK20.32962534
146MAPKAPK20.32267761
147STK100.31110423
148OBSCN0.29641468
149MAP3K110.29213632
150RET0.28045088
151TRPM70.27821686

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.74344068
2Nitrogen metabolism_Homo sapiens_hsa009103.10002934
3Complement and coagulation cascades_Homo sapiens_hsa046103.05336581
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90812797
5Fatty acid degradation_Homo sapiens_hsa000712.84620593
6Staphylococcus aureus infection_Homo sapiens_hsa051502.74296331
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70021540
8Allograft rejection_Homo sapiens_hsa053302.55312861
9PPAR signaling pathway_Homo sapiens_hsa033202.54172415
10Arginine biosynthesis_Homo sapiens_hsa002202.52438235
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51935590
12Tryptophan metabolism_Homo sapiens_hsa003802.50764007
13Asthma_Homo sapiens_hsa053102.48964429
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46757160
15Propanoate metabolism_Homo sapiens_hsa006402.38704799
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38536146
17Graft-versus-host disease_Homo sapiens_hsa053322.29867085
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23896540
19Autoimmune thyroid disease_Homo sapiens_hsa053202.22066051
20Fatty acid metabolism_Homo sapiens_hsa012122.21899342
21Rheumatoid arthritis_Homo sapiens_hsa053232.18941341
22Peroxisome_Homo sapiens_hsa041462.11564614
23Tuberculosis_Homo sapiens_hsa051522.05694050
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98322246
25Butanoate metabolism_Homo sapiens_hsa006501.95806934
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.93731511
27Caffeine metabolism_Homo sapiens_hsa002321.91962125
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88105003
29beta-Alanine metabolism_Homo sapiens_hsa004101.82549216
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80668197
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79486802
32Antigen processing and presentation_Homo sapiens_hsa046121.74661724
33Type I diabetes mellitus_Homo sapiens_hsa049401.73342383
34Chemical carcinogenesis_Homo sapiens_hsa052041.70209941
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69629372
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.65745158
37Phagosome_Homo sapiens_hsa041451.63896054
38Histidine metabolism_Homo sapiens_hsa003401.59000543
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.54613643
40Toxoplasmosis_Homo sapiens_hsa051451.48501380
41Retinol metabolism_Homo sapiens_hsa008301.45837657
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45364859
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44168595
44Bile secretion_Homo sapiens_hsa049761.43097255
45TNF signaling pathway_Homo sapiens_hsa046681.41867484
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40985946
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40047372
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38873829
49Phenylalanine metabolism_Homo sapiens_hsa003601.38822403
50Fatty acid elongation_Homo sapiens_hsa000621.35403938
51Viral myocarditis_Homo sapiens_hsa054161.34731734
52Pyruvate metabolism_Homo sapiens_hsa006201.34712017
53Hematopoietic cell lineage_Homo sapiens_hsa046401.33942451
54Salmonella infection_Homo sapiens_hsa051321.33849926
55Starch and sucrose metabolism_Homo sapiens_hsa005001.31553316
56Legionellosis_Homo sapiens_hsa051341.31143433
57ABC transporters_Homo sapiens_hsa020101.31043149
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.30628181
59B cell receptor signaling pathway_Homo sapiens_hsa046621.23052265
60Fat digestion and absorption_Homo sapiens_hsa049751.20949511
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20371788
62Influenza A_Homo sapiens_hsa051641.20362759
63Vitamin digestion and absorption_Homo sapiens_hsa049771.17807019
64Carbon metabolism_Homo sapiens_hsa012001.17499622
65Tyrosine metabolism_Homo sapiens_hsa003501.17316693
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15937324
67Sulfur metabolism_Homo sapiens_hsa009201.15603848
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10134471
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08565653
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08510237
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06185354
72Selenocompound metabolism_Homo sapiens_hsa004501.05035495
73Chemokine signaling pathway_Homo sapiens_hsa040621.02631984
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01805371
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97108312
76Glycerolipid metabolism_Homo sapiens_hsa005610.94077607
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91515146
78Folate biosynthesis_Homo sapiens_hsa007900.90879458
79Herpes simplex infection_Homo sapiens_hsa051680.90522913
80Fatty acid biosynthesis_Homo sapiens_hsa000610.90391060
81Acute myeloid leukemia_Homo sapiens_hsa052210.89007690
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88533446
83Biosynthesis of amino acids_Homo sapiens_hsa012300.87098442
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86713451
85Arginine and proline metabolism_Homo sapiens_hsa003300.84897548
86Collecting duct acid secretion_Homo sapiens_hsa049660.80969556
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79558063
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.77723199
89Measles_Homo sapiens_hsa051620.77700000
90Sulfur relay system_Homo sapiens_hsa041220.76732675
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.73900481
92Lysine degradation_Homo sapiens_hsa003100.73700998
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73293472
94Shigellosis_Homo sapiens_hsa051310.71985725
95Sphingolipid metabolism_Homo sapiens_hsa006000.69797183
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.69576033
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.69333686
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67630537
99Glutathione metabolism_Homo sapiens_hsa004800.66477786
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.66424390
101Primary immunodeficiency_Homo sapiens_hsa053400.65242688
102Apoptosis_Homo sapiens_hsa042100.64367738
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63993994
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63430453
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63096824
106Steroid biosynthesis_Homo sapiens_hsa001000.61396339
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.60336426
108T cell receptor signaling pathway_Homo sapiens_hsa046600.59582182
109Hepatitis B_Homo sapiens_hsa051610.59408865
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58710572
111Bladder cancer_Homo sapiens_hsa052190.57869762
112Other glycan degradation_Homo sapiens_hsa005110.57863198
113Malaria_Homo sapiens_hsa051440.57699002
114Vitamin B6 metabolism_Homo sapiens_hsa007500.54050010
115Pentose phosphate pathway_Homo sapiens_hsa000300.53190093
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52878271
117Insulin resistance_Homo sapiens_hsa049310.52758307
118Lysosome_Homo sapiens_hsa041420.52458293
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.52101853
120Platelet activation_Homo sapiens_hsa046110.50941460
121VEGF signaling pathway_Homo sapiens_hsa043700.47137467
122Prion diseases_Homo sapiens_hsa050200.46642155
123Vibrio cholerae infection_Homo sapiens_hsa051100.46471856
124Endocytosis_Homo sapiens_hsa041440.45766666
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40844555
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.40027849
127Prolactin signaling pathway_Homo sapiens_hsa049170.40010626
128Galactose metabolism_Homo sapiens_hsa000520.36768641
129Notch signaling pathway_Homo sapiens_hsa043300.35970305
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35938059
131Metabolic pathways_Homo sapiens_hsa011000.35497079
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34932350
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32103201
134Pertussis_Homo sapiens_hsa051330.32082836
135Arachidonic acid metabolism_Homo sapiens_hsa005900.31869665
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.31288336
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.30400683
138Fructose and mannose metabolism_Homo sapiens_hsa000510.30202675
139Epstein-Barr virus infection_Homo sapiens_hsa051690.29414332
140HIF-1 signaling pathway_Homo sapiens_hsa040660.28921103
141ECM-receptor interaction_Homo sapiens_hsa045120.27902321
142GnRH signaling pathway_Homo sapiens_hsa049120.25226451
143Protein digestion and absorption_Homo sapiens_hsa049740.23397825
144Chronic myeloid leukemia_Homo sapiens_hsa052200.23393785
145HTLV-I infection_Homo sapiens_hsa051660.21901994
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21349788
147AMPK signaling pathway_Homo sapiens_hsa041520.19297104
148African trypanosomiasis_Homo sapiens_hsa051430.18248650
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17306275
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.15809173
151Amoebiasis_Homo sapiens_hsa051460.13678164
152Linoleic acid metabolism_Homo sapiens_hsa005910.11474433
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10801322
154Renin-angiotensin system_Homo sapiens_hsa046140.10573673
155One carbon pool by folate_Homo sapiens_hsa006700.09990015
156Ovarian steroidogenesis_Homo sapiens_hsa049130.09060351
157Focal adhesion_Homo sapiens_hsa045100.05723089
158Mineral absorption_Homo sapiens_hsa049780.05372057
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.04881281
160Osteoclast differentiation_Homo sapiens_hsa043800.04354439
161Leishmaniasis_Homo sapiens_hsa051400.04145595
162Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.04139590
163Glucagon signaling pathway_Homo sapiens_hsa049220.03760127
164Hepatitis C_Homo sapiens_hsa051600.02250748

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