FCGR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.93257895
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.93257895
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.93257895
4modulation by symbiont of host immune response (GO:0052553)5.93257895
5positive regulation by symbiont of host defense response (GO:0052509)5.93257895
6modulation by symbiont of host defense response (GO:0052031)5.93257895
7macrophage activation involved in immune response (GO:0002281)5.47124505
8neutrophil activation involved in immune response (GO:0002283)5.41325530
9positive regulation of gamma-delta T cell activation (GO:0046645)5.35816523
10detection of molecule of bacterial origin (GO:0032490)5.26487373
11response to peptidoglycan (GO:0032494)5.25730088
12microglial cell activation (GO:0001774)5.06608578
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04916355
14negative regulation of cell killing (GO:0031342)5.04916355
15negative regulation of interleukin-12 production (GO:0032695)5.03488710
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88406462
17detection of other organism (GO:0098543)4.83765237
18detection of external biotic stimulus (GO:0098581)4.64868789
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.50766831
20cellular extravasation (GO:0045123)4.48418015
21detection of bacterium (GO:0016045)4.43496390
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40562818
23antigen processing and presentation of endogenous antigen (GO:0019883)4.35126665
24macrophage activation (GO:0042116)4.30227974
25regulation of interferon-beta biosynthetic process (GO:0045357)4.17266414
26detection of biotic stimulus (GO:0009595)4.13042761
27* immunoglobulin mediated immune response (GO:0016064)4.09438943
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.07033172
29response to host immune response (GO:0052572)4.03043071
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.03043071
31myeloid cell activation involved in immune response (GO:0002275)3.94450524
32respiratory burst (GO:0045730)3.89969747
33regulation of B cell receptor signaling pathway (GO:0050855)3.85026042
34regulation of mast cell degranulation (GO:0043304)3.80935782
35regulation of gamma-delta T cell activation (GO:0046643)3.78829842
36leukocyte aggregation (GO:0070486)3.72620301
37leukocyte migration involved in inflammatory response (GO:0002523)3.69235095
38neutrophil activation (GO:0042119)3.67697878
39production of molecular mediator involved in inflammatory response (GO:0002532)3.67554554
40* interferon-gamma-mediated signaling pathway (GO:0060333)3.64568348
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62038208
42response to host (GO:0075136)3.62038208
43response to host defenses (GO:0052200)3.62038208
44positive regulation of mast cell activation (GO:0033005)3.60012037
45granulocyte activation (GO:0036230)3.56628497
46type I interferon signaling pathway (GO:0060337)3.55023939
47cellular response to type I interferon (GO:0071357)3.55023939
48regulation of mast cell activation involved in immune response (GO:0033006)3.53946183
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53034434
50* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.52263956
51response to type I interferon (GO:0034340)3.51685711
52positive regulation of mast cell degranulation (GO:0043306)3.51675001
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.51675001
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.46283070
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.45032941
56regulation of leukocyte degranulation (GO:0043300)3.38418662
57regulation of mast cell activation (GO:0033003)3.38041467
58positive regulation of cellular amide metabolic process (GO:0034250)3.34201931
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.32880307
60response to muramyl dipeptide (GO:0032495)3.28539861
61regulation of T-helper 2 cell differentiation (GO:0045628)3.28350951
62positive regulation of antigen processing and presentation (GO:0002579)3.27265792
63positive regulation of interferon-alpha production (GO:0032727)3.26686670
64neutrophil mediated immunity (GO:0002446)3.26090012
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25612773
66negative regulation of leukocyte mediated immunity (GO:0002704)3.24861253
67regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.20400965
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20000751
69germinal center formation (GO:0002467)3.19947398
70regulation of antigen processing and presentation (GO:0002577)3.19830848
71positive regulation of toll-like receptor signaling pathway (GO:0034123)3.16707563
72regulation of interferon-alpha production (GO:0032647)3.15303294
73defense response to protozoan (GO:0042832)3.13777693
74* positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.11961622
75regulation of tolerance induction (GO:0002643)3.09648600
76* B cell mediated immunity (GO:0019724)3.09611258
77T-helper 1 type immune response (GO:0042088)3.09541595
78myeloid leukocyte activation (GO:0002274)3.03017586
79positive regulation of type 2 immune response (GO:0002830)3.02218885
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01965689
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01671731
82regulation of gamma-delta T cell differentiation (GO:0045586)3.00513969
83regulation of T cell tolerance induction (GO:0002664)2.98907960
84neutrophil chemotaxis (GO:0030593)2.97170076
85negative regulation of T cell mediated immunity (GO:0002710)2.96430493
86negative regulation of innate immune response (GO:0045824)2.94469913
87negative regulation of cytokine production involved in immune response (GO:0002719)2.93117268
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90646124
89neutrophil migration (GO:1990266)2.89368945
90positive regulation of B cell differentiation (GO:0045579)2.88832968
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88052337
92antigen processing and presentation via MHC class Ib (GO:0002475)2.87130588
93positive regulation of leukocyte degranulation (GO:0043302)2.86475788
94regulation of regulated secretory pathway (GO:1903305)2.85021552
95leukocyte degranulation (GO:0043299)2.84845113
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80925824
97negative regulation of T-helper cell differentiation (GO:0045623)2.80925824
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79879764
99* cellular response to interferon-gamma (GO:0071346)2.79503311
100response to protozoan (GO:0001562)2.79209852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.49162773
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.05912430
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.88640006
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.91970389
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67272348
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62007331
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.59195697
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.13769251
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13315276
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13282637
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09751861
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03298152
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77869128
14VDR_24763502_ChIP-Seq_THP-1_Human2.75573262
15SPI1_23547873_ChIP-Seq_NB4_Human2.70861210
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68919671
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63508559
18* SPI1_23127762_ChIP-Seq_K562_Human2.63120209
19VDR_21846776_ChIP-Seq_THP-1_Human2.52393175
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45043479
21SCL_19346495_ChIP-Seq_HPC-7_Human2.41675627
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39689210
23VDR_24787735_ChIP-Seq_THP-1_Human2.34500417
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18835234
25RUNX_20019798_ChIP-Seq_JUKART_Human2.17389484
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17338603
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15571149
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99156256
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.97064665
30MYB_26560356_Chip-Seq_TH2_Human1.92633594
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90923700
32MAF_26560356_Chip-Seq_TH1_Human1.86644102
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81010078
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77937625
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73974949
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.70572931
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.69769302
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66067561
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63575602
40MYB_26560356_Chip-Seq_TH1_Human1.59432514
41GATA1_22025678_ChIP-Seq_K562_Human1.58902891
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57420624
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54932495
44UTX_26944678_Chip-Seq_JUKART_Human1.53090920
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52899964
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.52799865
47PU_27001747_Chip-Seq_BMDM_Mouse1.47057523
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46974728
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46657118
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.43026404
51TCF7_22412390_ChIP-Seq_EML_Mouse1.41576640
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37002881
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35015212
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34606506
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32562618
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30794488
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28567118
58KDM2B_26808549_Chip-Seq_DND41_Human1.27604150
59MAF_26560356_Chip-Seq_TH2_Human1.26497152
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25844968
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24762440
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23488208
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21839379
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20843665
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20713015
66* GATA3_26560356_Chip-Seq_TH2_Human1.20312298
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19990922
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19457414
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18239685
70MYC_22102868_ChIP-Seq_BL_Human1.17286850
71GATA1_19941826_ChIP-Seq_K562_Human1.16465460
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16260091
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14164321
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14008941
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12118671
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11560601
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09887145
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07056818
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05158399
80LXR_22292898_ChIP-Seq_THP-1_Human1.04969527
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.04388381
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02498193
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.98611833
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94718759
85GATA2_19941826_ChIP-Seq_K562_Human0.93148447
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88872941
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86722932
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86698532
89TFEB_21752829_ChIP-Seq_HELA_Human0.85381674
90STAT1_20625510_ChIP-Seq_HELA_Human0.83552523
91* BCL6_27268052_Chip-Seq_Bcells_Human0.83516596
92SPI1_20517297_ChIP-Seq_HL60_Human0.76948303
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75631018
94* BCOR_27268052_Chip-Seq_Bcells_Human0.75174942
95SMRT_27268052_Chip-Seq_Bcells_Human0.75007458
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74401213
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.72967305
98EGR1_19032775_ChIP-ChIP_M12_Human0.71752322
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69657040
100NCOR1_26117541_ChIP-Seq_K562_Human0.67943427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.67513051
2MP0001835_abnormal_antigen_presentation3.95429562
3MP0003436_decreased_susceptibility_to3.58977225
4MP0003303_peritoneal_inflammation3.54791422
5MP0006082_CNS_inflammation3.38769459
6MP0002419_abnormal_innate_immunity3.24479159
7MP0009785_altered_susceptibility_to3.14096174
8MP0005025_abnormal_response_to2.89144735
9MP0005671_abnormal_response_to2.88649548
10MP0001790_abnormal_immune_system2.80878764
11MP0005387_immune_system_phenotype2.80878764
12MP0000685_abnormal_immune_system2.72847332
13MP0005000_abnormal_immune_tolerance2.71579959
14MP0002148_abnormal_hypersensitivity_rea2.69974183
15MP0003191_abnormal_cellular_cholesterol2.63885949
16MP0001800_abnormal_humoral_immune2.59486097
17MP0005058_abnormal_lysosome_morphology2.56642904
18MP0003172_abnormal_lysosome_physiology2.55294869
19MP0002452_abnormal_antigen_presenting2.46483271
20MP0002723_abnormal_immune_serum2.45033263
21MP0003300_gastrointestinal_ulcer2.33719408
22MP0002420_abnormal_adaptive_immunity2.23663766
23MP0001819_abnormal_immune_cell2.22580551
24MP0005464_abnormal_platelet_physiology2.12477802
25MP0001533_abnormal_skeleton_physiology2.10242615
26MP0008260_abnormal_autophagy2.09904611
27MP0009278_abnormal_bone_marrow1.91658765
28MP0009840_abnormal_foam_cell1.88865684
29MP0003690_abnormal_glial_cell1.85945707
30MP0001845_abnormal_inflammatory_respons1.84802714
31MP0002405_respiratory_system_inflammati1.81664373
32MP0000604_amyloidosis1.79129901
33MP0003828_pulmonary_edema1.75402028
34MP0003075_altered_response_to1.70922795
35MP0000343_altered_response_to1.70645668
36MP0009764_decreased_sensitivity_to1.68771811
37MP0000716_abnormal_immune_system1.61071289
38MP0004883_abnormal_blood_vessel1.60031152
39MP0000569_abnormal_digit_pigmentation1.58406492
40MP0008469_abnormal_protein_level1.58025751
41MP0001545_abnormal_hematopoietic_system1.57799170
42MP0005397_hematopoietic_system_phenotyp1.57799170
43MP0005310_abnormal_salivary_gland1.55410848
44MP0002998_abnormal_bone_remodeling1.51881365
45MP0010155_abnormal_intestine_physiology1.50797970
46MP0004947_skin_inflammation1.50639069
47MP0002398_abnormal_bone_marrow1.46841609
48MP0005451_abnormal_body_composition1.37490089
49MP0000858_altered_metastatic_potential1.36812466
50MP0002277_abnormal_respiratory_mucosa1.33917961
51MP0000465_gastrointestinal_hemorrhage1.33289111
52MP0004510_myositis1.32641244
53MP0005164_abnormal_response_to1.30768779
54MP0000689_abnormal_spleen_morphology1.29767084
55MP0003806_abnormal_nucleotide_metabolis1.29140895
56MP0001853_heart_inflammation1.28106013
57MP0003763_abnormal_thymus_physiology1.25162206
58MP0002429_abnormal_blood_cell1.24025948
59MP0002132_abnormal_respiratory_system1.23974764
60MP0009333_abnormal_splenocyte_physiolog1.22867239
61MP0002722_abnormal_immune_system1.21610199
62MP0005167_abnormal_blood-brain_barrier1.17766529
63MP0005166_decreased_susceptibility_to1.13704889
64MP0003183_abnormal_peptide_metabolism1.12877171
65MP0002166_altered_tumor_susceptibility1.11984554
66MP0003448_altered_tumor_morphology1.11172648
67MP0003866_abnormal_defecation1.10871599
68MP0003656_abnormal_erythrocyte_physiolo1.06410871
69MP0003329_amyloid_beta_deposits0.99726608
70MP0001851_eye_inflammation0.95786056
71MP0009763_increased_sensitivity_to0.94209562
72MP0004381_abnormal_hair_follicle0.92648249
73MP0000920_abnormal_myelination0.91777226
74MP0008004_abnormal_stomach_pH0.91731719
75MP0000015_abnormal_ear_pigmentation0.84535769
76MP0000703_abnormal_thymus_morphology0.81094382
77MP0000249_abnormal_blood_vessel0.79944233
78MP0003195_calcinosis0.77635440
79MP0002396_abnormal_hematopoietic_system0.76639643
80MP0005390_skeleton_phenotype0.76447882
81MP0004808_abnormal_hematopoietic_stem0.74179487
82MP0001663_abnormal_digestive_system0.73686897
83MP0003795_abnormal_bone_structure0.73557850
84MP0002006_tumorigenesis0.70054030
85MP0008874_decreased_physiological_sensi0.66614290
86MP0003091_abnormal_cell_migration0.62203156
87MP0002138_abnormal_hepatobiliary_system0.60845139
88MP0002332_abnormal_exercise_endurance0.60643955
89MP0009765_abnormal_xenobiotic_induced0.57118687
90MP0002933_joint_inflammation0.56457485
91MP0005174_abnormal_tail_pigmentation0.56186674
92MP0003221_abnormal_cardiomyocyte_apopto0.55860831
93MP0005319_abnormal_enzyme/_coenzyme0.55176362
94MP0005075_abnormal_melanosome_morpholog0.54284793
95MP0003453_abnormal_keratinocyte_physiol0.53691248
96MP0005584_abnormal_enzyme/coenzyme_acti0.51711038
97MP0006054_spinal_hemorrhage0.50449799
98MP0001542_abnormal_bone_strength0.50007396
99MP0000371_diluted_coat_color0.49735557
100MP0005376_homeostasis/metabolism_phenot0.48545222

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.37694560
2Recurrent abscess formation (HP:0002722)6.19394425
3Eczematoid dermatitis (HP:0000976)6.15852474
4Abnormality of macrophages (HP:0004311)5.62768582
5Systemic lupus erythematosus (HP:0002725)5.07583071
6Myositis (HP:0100614)4.97928534
7Recurrent gram-negative bacterial infections (HP:0005420)4.93070425
8Orchitis (HP:0100796)4.75994018
9Optic neuritis (HP:0100653)4.55342197
10Retrobulbar optic neuritis (HP:0100654)4.55342197
11Abnormality of glycolipid metabolism (HP:0010969)4.51437602
12Abnormality of liposaccharide metabolism (HP:0010968)4.51437602
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.51437602
14Mediastinal lymphadenopathy (HP:0100721)4.35361283
15Elevated erythrocyte sedimentation rate (HP:0003565)4.17079282
16Recurrent skin infections (HP:0001581)4.13654127
17Stomatitis (HP:0010280)3.91741944
18Recurrent fungal infections (HP:0002841)3.85715620
19Obstructive lung disease (HP:0006536)3.74352268
20Chronic obstructive pulmonary disease (HP:0006510)3.74352268
21Gingivitis (HP:0000230)3.67332485
22Chronic mucocutaneous candidiasis (HP:0002728)3.66213987
23Recurrent cutaneous fungal infections (HP:0011370)3.66213987
24Increased cerebral lipofuscin (HP:0011813)3.55004902
25Glomerulonephritis (HP:0000099)3.54233582
26Meningitis (HP:0001287)3.44757914
27Gastrointestinal infarctions (HP:0005244)3.42599610
28Spontaneous hematomas (HP:0007420)3.36746342
29Disinhibition (HP:0000734)3.23042292
30Keratoconjunctivitis sicca (HP:0001097)3.19483268
31Amyloidosis (HP:0011034)3.12471921
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.09761871
33Hemoptysis (HP:0002105)3.07196034
34Urticaria (HP:0001025)3.04515162
35Loss of speech (HP:0002371)2.97748174
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.92967710
37Vasculitis (HP:0002633)2.92568000
38Keratoconjunctivitis (HP:0001096)2.92416299
39Encephalitis (HP:0002383)2.91498134
40Pulmonary infiltrates (HP:0002113)2.88146945
41Cellulitis (HP:0100658)2.72307942
42Vacuolated lymphocytes (HP:0001922)2.70163473
43Dysostosis multiplex (HP:0000943)2.64653013
44T lymphocytopenia (HP:0005403)2.63957508
45Chest pain (HP:0100749)2.63781626
46Recurrent viral infections (HP:0004429)2.62091922
47Arterial thrombosis (HP:0004420)2.60379236
48Gingival bleeding (HP:0000225)2.60267649
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59664491
50Abnormality of T cell number (HP:0011839)2.56129805
51Complement deficiency (HP:0004431)2.54871099
52Mutism (HP:0002300)2.52755766
53Leukocytosis (HP:0001974)2.51812452
54Peritonitis (HP:0002586)2.50826818
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48578114
56Osteomyelitis (HP:0002754)2.43888825
57Epistaxis (HP:0000421)2.43171366
58Autoimmune thrombocytopenia (HP:0001973)2.42393487
59Pulmonary embolism (HP:0002204)2.39173102
60Purpura (HP:0000979)2.36587491
61Episodic fever (HP:0001954)2.36484563
62Increased IgE level (HP:0003212)2.36471093
63Pustule (HP:0200039)2.32737915
64Premature loss of primary teeth (HP:0006323)2.32332174
65Prolonged bleeding time (HP:0003010)2.30902621
66Increased serum ferritin (HP:0003281)2.29965730
67Anorexia (HP:0002039)2.29021568
68Petechiae (HP:0000967)2.24160400
69Inflammation of the large intestine (HP:0002037)2.23976584
70Abnormality of the peritoneum (HP:0002585)2.21342118
71Chronic otitis media (HP:0000389)2.20872181
72Abnormality of complement system (HP:0005339)2.19964008
73Upper motor neuron abnormality (HP:0002127)2.17818085
74Agnosia (HP:0010524)2.16147341
75Abnormality of iron homeostasis (HP:0011031)2.14251715
76Axonal loss (HP:0003447)2.13281873
77Colitis (HP:0002583)2.13215898
78Hypergammaglobulinemia (HP:0010702)2.12316243
79Cheilitis (HP:0100825)2.11352902
80Gastrointestinal inflammation (HP:0004386)2.10177899
81Gangrene (HP:0100758)2.08967898
82Abnormality of the pleura (HP:0002103)2.07739947
83Abnormality of the endocardium (HP:0004306)2.05915827
84Abnormality of T cells (HP:0002843)2.03750465
85Myocardial infarction (HP:0001658)2.03613378
86Increased IgM level (HP:0003496)2.03192284
87Abnormality of polysaccharide metabolism (HP:0011012)2.02029954
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02029954
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02029954
90Hepatosplenomegaly (HP:0001433)2.00889087
91Malnutrition (HP:0004395)2.00155503
92Vertigo (HP:0002321)1.98991766
93Granulocytopenia (HP:0001913)1.97899927
94Basal ganglia calcification (HP:0002135)1.97368736
95Interstitial pulmonary disease (HP:0006530)1.96120302
96Polyneuropathy (HP:0001271)1.93540971
97Neuronal loss in central nervous system (HP:0002529)1.93483009
98Pathologic fracture (HP:0002756)1.93196782
99Abnormality of the nasal mucosa (HP:0000433)1.91253825
100Glomerulopathy (HP:0100820)1.91139368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.60460233
2BLK4.30478478
3TYK23.17896807
4IRAK42.85904079
5MAP2K32.79844171
6MAP4K12.77356333
7CSK2.69602577
8ERN12.40083001
9FES2.32828976
10JAK32.27077061
11FGR2.22339818
12ZAP702.19400254
13MAP3K142.05301098
14TGFBR21.97198660
15IKBKE1.92595032
16SYK1.79885444
17TNK21.78995837
18TBK11.76937726
19CSF1R1.75246664
20TXK1.67040583
21BTK1.66443586
22JAK11.64472332
23GRK61.61893168
24KIT1.55994907
25MAP3K131.55318883
26HCK1.54182033
27MAP3K31.53687564
28JAK21.53445111
29LYN1.53079951
30MAP3K111.49757819
31GRK71.45864064
32TAOK11.45855886
33EPHB11.37826455
34MATK1.35667255
35BMPR21.25988116
36MAP3K11.21316985
37PRPF4B1.17397770
38ITK1.15506287
39IKBKB1.14705673
40LCK1.11098305
41MARK31.11070288
42IRAK31.10907369
43MAP3K61.07093817
44IRAK11.06151026
45TAOK31.04947939
46YES11.00990563
47IRAK20.99433939
48TEC0.94273421
49PDK10.92416222
50CAMK1D0.90735599
51KSR20.90035615
52CDC42BPA0.88834540
53MARK20.87733755
54PDPK10.86845023
55MAP3K50.85138314
56TAOK20.83926417
57CAMKK20.81015827
58MOS0.78770458
59PIK3CG0.74083584
60STK100.70705597
61FGFR30.69024681
62FGFR40.64491236
63MAPK120.61044739
64MAPK70.60155067
65FYN0.59979424
66MAP3K20.59169464
67LRRK20.58554419
68PTK2B0.56777301
69SIK30.55197249
70CDK60.54757203
71ACVR1B0.54515130
72TESK20.53908612
73EPHA30.53653541
74MAP2K60.52752657
75PIM10.51691742
76PTK60.50123660
77SGK30.49660199
78MAP2K40.48932505
79PRKD20.47141191
80RET0.42804546
81HIPK20.40727719
82KSR10.39325996
83SGK20.39313475
84RIPK10.39220787
85ABL10.39094572
86RPS6KL10.38766493
87RPS6KC10.38766493
88CAMK1G0.38698979
89MAPKAPK20.37112086
90CHUK0.35860395
91SIK20.35316750
92STK110.34631347
93DYRK1B0.34403803
94MAP3K70.33416878
95CAMK40.33386184
96PRKCQ0.32572973
97RPS6KA60.31455546
98PRKCD0.31204685
99PRKG20.30484990
100CDK190.29433471

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051503.81155935
2* Leishmaniasis_Homo sapiens_hsa051403.15082165
3* Osteoclast differentiation_Homo sapiens_hsa043802.97570574
4Allograft rejection_Homo sapiens_hsa053302.58599833
5Graft-versus-host disease_Homo sapiens_hsa053322.54201576
6* Tuberculosis_Homo sapiens_hsa051522.37162794
7Autoimmune thyroid disease_Homo sapiens_hsa053202.34475978
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32367422
9Other glycan degradation_Homo sapiens_hsa005112.22888555
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08291093
11Asthma_Homo sapiens_hsa053102.04607110
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02951788
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01286863
14Antigen processing and presentation_Homo sapiens_hsa046121.94855495
15Type I diabetes mellitus_Homo sapiens_hsa049401.91317337
16Legionellosis_Homo sapiens_hsa051341.89872578
17Lysosome_Homo sapiens_hsa041421.89002966
18B cell receptor signaling pathway_Homo sapiens_hsa046621.87902829
19Malaria_Homo sapiens_hsa051441.87605733
20* Phagosome_Homo sapiens_hsa041451.86573946
21Rheumatoid arthritis_Homo sapiens_hsa053231.79794100
22* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78594250
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.75238606
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73880712
25Pertussis_Homo sapiens_hsa051331.71482457
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.62130385
27Toxoplasmosis_Homo sapiens_hsa051451.60304502
28Influenza A_Homo sapiens_hsa051641.58828687
29Chemokine signaling pathway_Homo sapiens_hsa040621.50997664
30Viral myocarditis_Homo sapiens_hsa054161.50964876
31Measles_Homo sapiens_hsa051621.49731525
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46954196
33* Hematopoietic cell lineage_Homo sapiens_hsa046401.36938664
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35933186
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31508211
36Primary immunodeficiency_Homo sapiens_hsa053401.29988483
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.28607334
38Herpes simplex infection_Homo sapiens_hsa051681.25854727
39TNF signaling pathway_Homo sapiens_hsa046681.21664297
40Salmonella infection_Homo sapiens_hsa051321.16566693
41Acute myeloid leukemia_Homo sapiens_hsa052211.13957735
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.11638159
43African trypanosomiasis_Homo sapiens_hsa051431.08611185
44T cell receptor signaling pathway_Homo sapiens_hsa046601.04525226
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98856787
46Platelet activation_Homo sapiens_hsa046110.97042391
47Complement and coagulation cascades_Homo sapiens_hsa046100.96210348
48Hepatitis C_Homo sapiens_hsa051600.94917750
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93900271
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93144494
51Hepatitis B_Homo sapiens_hsa051610.90988089
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89399235
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.86561407
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85853260
55Apoptosis_Homo sapiens_hsa042100.85312282
56Shigellosis_Homo sapiens_hsa051310.78680706
57Non-small cell lung cancer_Homo sapiens_hsa052230.73949908
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71853637
59Collecting duct acid secretion_Homo sapiens_hsa049660.71132069
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70992876
61Prolactin signaling pathway_Homo sapiens_hsa049170.69498390
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68233189
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.66524354
64Prion diseases_Homo sapiens_hsa050200.65529141
65VEGF signaling pathway_Homo sapiens_hsa043700.64150223
66Pancreatic cancer_Homo sapiens_hsa052120.63846230
67* Systemic lupus erythematosus_Homo sapiens_hsa053220.63044476
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.60586391
69Amoebiasis_Homo sapiens_hsa051460.60182978
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60057324
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58447956
72Endocytosis_Homo sapiens_hsa041440.55643251
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.52067346
74Chronic myeloid leukemia_Homo sapiens_hsa052200.50390321
75Epstein-Barr virus infection_Homo sapiens_hsa051690.48465200
76Renal cell carcinoma_Homo sapiens_hsa052110.48207907
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.47971601
78Viral carcinogenesis_Homo sapiens_hsa052030.46576706
79HIF-1 signaling pathway_Homo sapiens_hsa040660.46038407
80GnRH signaling pathway_Homo sapiens_hsa049120.45126165
81Dorso-ventral axis formation_Homo sapiens_hsa043200.44252368
82Notch signaling pathway_Homo sapiens_hsa043300.44197112
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43686290
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43429983
85FoxO signaling pathway_Homo sapiens_hsa040680.42018896
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40580998
87* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39288252
88HTLV-I infection_Homo sapiens_hsa051660.37457941
89Type II diabetes mellitus_Homo sapiens_hsa049300.33549657
90Galactose metabolism_Homo sapiens_hsa000520.32898772
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32431026
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29624476
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28762928
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28729473
95MAPK signaling pathway_Homo sapiens_hsa040100.28228562
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26477448
97Estrogen signaling pathway_Homo sapiens_hsa049150.25936682
98Rap1 signaling pathway_Homo sapiens_hsa040150.25862783
99Choline metabolism in cancer_Homo sapiens_hsa052310.25321491
100Endometrial cancer_Homo sapiens_hsa052130.23464569

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