FBXO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)6.96005020
2activation of MAPKKK activity (GO:0000185)6.37302984
3positive regulation of defense response to virus by host (GO:0002230)5.13906081
4positive regulation of gamma-delta T cell activation (GO:0046645)4.52440249
5cellular response to type I interferon (GO:0071357)4.42677404
6type I interferon signaling pathway (GO:0060337)4.42677404
7response to type I interferon (GO:0034340)4.36112897
8cytidine metabolic process (GO:0046087)4.34479307
9cytidine catabolic process (GO:0006216)4.34479307
10cytidine deamination (GO:0009972)4.34479307
11negative regulation of interleukin-12 production (GO:0032695)4.26140957
12lymphocyte chemotaxis (GO:0048247)4.02754251
13pyrimidine ribonucleoside catabolic process (GO:0046133)3.84083708
14negative regulation of viral genome replication (GO:0045071)3.74982714
15positive regulation of monocyte chemotaxis (GO:0090026)3.57951161
16T cell migration (GO:0072678)3.57064116
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57026458
18regulation of defense response to virus by host (GO:0050691)3.56602687
19macrophage activation involved in immune response (GO:0002281)3.54764112
20DNA deamination (GO:0045006)3.54745114
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.51526918
22folic acid metabolic process (GO:0046655)3.50347496
23negative regulation of cell killing (GO:0031342)3.49798024
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49798024
25cellular response to exogenous dsRNA (GO:0071360)3.43442000
26regulation of regulatory T cell differentiation (GO:0045589)3.41493744
27regulation of lymphocyte migration (GO:2000401)3.37151264
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34885792
29interferon-gamma-mediated signaling pathway (GO:0060333)3.33723841
30macroautophagy (GO:0016236)3.32542701
31regulation of gamma-delta T cell activation (GO:0046643)3.31517385
32regulation of natural killer cell mediated immunity (GO:0002715)3.26960397
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26960397
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26911243
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26911243
36regulation of B cell receptor signaling pathway (GO:0050855)3.25142682
37I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.24659065
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24631702
39proteasome assembly (GO:0043248)3.24324473
40nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.23861356
41formation of translation preinitiation complex (GO:0001731)3.20774722
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20624472
43regulation of T cell mediated cytotoxicity (GO:0001914)3.20373406
44positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.20075550
45regulation of chronic inflammatory response (GO:0002676)3.18935529
46glycine metabolic process (GO:0006544)3.18876600
47regulation of antigen processing and presentation (GO:0002577)3.18603130
48cellular response to interleukin-15 (GO:0071350)3.12440305
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11735835
50cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.08186694
51L-phenylalanine metabolic process (GO:0006558)3.06754635
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.06754635
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02641418
54regulation of T-helper 1 cell differentiation (GO:0045625)3.02636004
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.02434332
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01616352
57defense response to protozoan (GO:0042832)3.00093065
58purine nucleobase biosynthetic process (GO:0009113)2.93019382
59serine family amino acid catabolic process (GO:0009071)2.92109234
60regulation of interleukin-12 production (GO:0032655)2.92010686
61positive regulation of antigen processing and presentation (GO:0002579)2.91769585
62regulation of gamma-delta T cell differentiation (GO:0045586)2.90295697
63antigen processing and presentation of endogenous antigen (GO:0019883)2.88936445
64cellular response to interferon-beta (GO:0035458)2.87378997
65regulation of cellular amino acid metabolic process (GO:0006521)2.87286962
66regulation of cell killing (GO:0031341)2.86622345
67positive regulation of natural killer cell mediated immunity (GO:0002717)2.86173566
68lymphocyte migration (GO:0072676)2.86116967
69response to protozoan (GO:0001562)2.84581496
70ribosomal small subunit assembly (GO:0000028)2.84519023
71regulation of interleukin-1 beta secretion (GO:0050706)2.84100393
72regulation of activation of Janus kinase activity (GO:0010533)2.83279739
73regulation of interferon-alpha production (GO:0032647)2.82967711
74interferon-gamma secretion (GO:0072643)2.82762744
75positive regulation of humoral immune response (GO:0002922)2.81961202
76sulfur amino acid catabolic process (GO:0000098)2.81838923
77positive regulation of interleukin-1 beta secretion (GO:0050718)2.80543247
78response to peptidoglycan (GO:0032494)2.80355140
79immunoglobulin mediated immune response (GO:0016064)2.80053303
80negative regulation of cytokine production involved in immune response (GO:0002719)2.79192431
81kynurenine metabolic process (GO:0070189)2.78179672
82myeloid dendritic cell differentiation (GO:0043011)2.77525077
83granulocyte activation (GO:0036230)2.77013431
84tryptophan catabolic process (GO:0006569)2.76692551
85indole-containing compound catabolic process (GO:0042436)2.76692551
86indolalkylamine catabolic process (GO:0046218)2.76692551
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.75066527
88response to interleukin-15 (GO:0070672)2.74320651
89cysteine metabolic process (GO:0006534)2.73978423
90interferon-gamma production (GO:0032609)2.73486341
91nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.72318564
92neutrophil activation involved in immune response (GO:0002283)2.71723911
93regulation of T cell tolerance induction (GO:0002664)2.71138305
94aromatic amino acid family catabolic process (GO:0009074)2.71002208
95response to interferon-gamma (GO:0034341)2.70953114
96aldehyde catabolic process (GO:0046185)2.70230484
97rRNA transcription (GO:0009303)2.70063650
98L-phenylalanine catabolic process (GO:0006559)2.68248990
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.68248990
100cellular response to interferon-gamma (GO:0071346)2.68020401
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67144115
102positive regulation of interleukin-1 secretion (GO:0050716)2.67056024
103positive regulation of cell killing (GO:0031343)2.66428895
104positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.66420660
105modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65852002
106positive regulation by organism of defense response of other organism involved in symbiotic interact2.65852002
107modulation by symbiont of host immune response (GO:0052553)2.65852002
108positive regulation by symbiont of host defense response (GO:0052509)2.65852002
109modulation by symbiont of host defense response (GO:0052031)2.65852002
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65852002
111cellular defense response (GO:0006968)2.65080584
112folic acid transport (GO:0015884)2.64934020
113amino sugar catabolic process (GO:0046348)2.64638950
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64000733
115positive regulation of B cell mediated immunity (GO:0002714)2.62690577
116positive regulation of immunoglobulin mediated immune response (GO:0002891)2.62690577
117regulation of monocyte chemotaxis (GO:0090025)2.62134633
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60898368
119regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60489976
120regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59969957
121defense response to virus (GO:0051607)2.59704290
122serine family amino acid metabolic process (GO:0009069)2.57028921
123nucleobase biosynthetic process (GO:0046112)2.56842063
124protein carboxylation (GO:0018214)2.56611318
125peptidyl-glutamic acid carboxylation (GO:0017187)2.56611318
126response to interferon-beta (GO:0035456)2.55735430
127termination of RNA polymerase III transcription (GO:0006386)2.55632547
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.55632547
129triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55141513
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55135407
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55135407
132antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.54305413
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54259943
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54024442
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54024442
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54024442
137glyoxylate metabolic process (GO:0046487)2.53606330
138homocysteine metabolic process (GO:0050667)2.53160097
139amino acid salvage (GO:0043102)2.53069521
140L-methionine salvage (GO:0071267)2.53069521
141L-methionine biosynthetic process (GO:0071265)2.53069521
142maturation of SSU-rRNA (GO:0030490)2.52819182
143tryptophan metabolic process (GO:0006568)2.52157315
144sulfur amino acid biosynthetic process (GO:0000097)2.50691527
145ribosomal large subunit biogenesis (GO:0042273)2.49967018
146signal transduction involved in DNA damage checkpoint (GO:0072422)2.48204185
147signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48204185
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47452746
149B cell mediated immunity (GO:0019724)2.47353223
150fructose metabolic process (GO:0006000)2.46122580
151ribosome biogenesis (GO:0042254)2.45072461
152serine family amino acid biosynthetic process (GO:0009070)2.44316475
153viral transcription (GO:0019083)2.44106346
154amino-acid betaine metabolic process (GO:0006577)2.42574744
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42549817
156positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.42163387
157signal transduction involved in cell cycle checkpoint (GO:0072395)2.40807679
158negative regulation of ligase activity (GO:0051352)2.40605478
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40605478
160regulation of cholesterol esterification (GO:0010872)2.37106714
161antigen processing and presentation via MHC class Ib (GO:0002475)2.37018358
162translational termination (GO:0006415)2.36833483
163rRNA modification (GO:0000154)2.36423931
164ribonucleoprotein complex biogenesis (GO:0022613)2.35777033
165anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.35482281
166regulation of protein activation cascade (GO:2000257)2.35277577
167endosome to pigment granule transport (GO:0043485)2.34856430
168endosome to melanosome transport (GO:0035646)2.34856430
169NAD biosynthetic process (GO:0009435)2.34830463
170heme transport (GO:0015886)2.34763923
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.33133625
172methionine metabolic process (GO:0006555)2.32370114
173positive regulation of interferon-beta production (GO:0032728)2.31661948
174methionine biosynthetic process (GO:0009086)2.31090041
175N-acetylneuraminate metabolic process (GO:0006054)2.30625953
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30121692
177regulation of RIG-I signaling pathway (GO:0039535)2.29691215
178response to interferon-alpha (GO:0035455)2.29403528
179aromatic amino acid family metabolic process (GO:0009072)2.28741807
180positive regulation of interferon-alpha production (GO:0032727)2.28241514
181skeletal muscle tissue regeneration (GO:0043403)2.28136056
182hydrogen peroxide biosynthetic process (GO:0050665)2.27781008
183nicotinamide nucleotide biosynthetic process (GO:0019359)2.27775087
184pyridine nucleotide biosynthetic process (GO:0019363)2.27775087
185folic acid-containing compound metabolic process (GO:0006760)2.26706306
186NADH metabolic process (GO:0006734)2.25923546
187positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.25880646
188regulation of complement activation (GO:0030449)2.25574032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70367419
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18721373
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17664170
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.94423831
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87311553
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.73498628
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.59527061
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58646259
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.57056598
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.54725593
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47657115
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44205607
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.40356148
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.29923382
15E2F7_22180533_ChIP-Seq_HELA_Human2.27767267
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22964115
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22173184
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.20854079
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19791137
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13323078
21MYB_26560356_Chip-Seq_TH2_Human2.10814967
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.09229822
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05536249
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98415184
25RUNX_20019798_ChIP-Seq_JUKART_Human1.95780040
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93135554
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93078684
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92479379
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89167357
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87242878
31STAT1_20625510_ChIP-Seq_HELA_Human1.82523461
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82481056
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80261464
34GATA3_26560356_Chip-Seq_TH2_Human1.79801723
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76592605
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75400265
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71142927
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.70570818
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68122646
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.67389114
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67062809
42GATA3_27048872_Chip-Seq_THYMUS_Human1.62539821
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.61758771
44VDR_23849224_ChIP-Seq_CD4+_Human1.61750222
45DCP1A_22483619_ChIP-Seq_HELA_Human1.61038968
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60596201
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.56604011
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54043864
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52638780
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51343829
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49858465
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49844335
53* MAF_26560356_Chip-Seq_TH1_Human1.48275420
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47434311
55* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47329281
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46633633
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46118539
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44316952
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41636438
60XRN2_22483619_ChIP-Seq_HELA_Human1.40844726
61SPI1_23127762_ChIP-Seq_K562_Human1.40358155
62GABP_19822575_ChIP-Seq_HepG2_Human1.39867974
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38531482
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38449710
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37374683
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36652254
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35226303
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.34718860
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32454702
70ZNF263_19887448_ChIP-Seq_K562_Human1.31953242
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.30888836
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29305138
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28448066
74SPI1_23547873_ChIP-Seq_NB4_Human1.27987450
75FOXP3_21729870_ChIP-Seq_TREG_Human1.24857312
76* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22715856
77* MYB_26560356_Chip-Seq_TH1_Human1.20450252
78* MAF_26560356_Chip-Seq_TH2_Human1.19135333
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18940138
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18860810
81P300_27268052_Chip-Seq_Bcells_Human1.18812744
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18750949
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18582860
84UTX_26944678_Chip-Seq_JUKART_Human1.18416561
85TAF2_19829295_ChIP-Seq_ESCs_Human1.17882029
86* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17319689
87GATA1_22025678_ChIP-Seq_K562_Human1.17290780
88* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16583979
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16430815
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16336374
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16125406
92BCOR_27268052_Chip-Seq_Bcells_Human1.15394264
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15378716
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15276916
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14276010
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14263395
97* E2F1_20622854_ChIP-Seq_HELA_Human1.13453178
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12592301
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12452356
100* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12352050
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11413156
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10790559
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10647283
104TFEB_21752829_ChIP-Seq_HELA_Human1.10437280
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08032013
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07876846
107IRF8_27001747_Chip-Seq_BMDM_Mouse1.07188423
108SA1_27219007_Chip-Seq_Bcells_Human1.06750158
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.06491440
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04805564
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04475150
112NANOG_20526341_ChIP-Seq_ESCs_Human1.04344975
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.03755896
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02621814
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01696990
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01108415
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01023350
118* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00802840
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00543181
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99882443
121BP1_19119308_ChIP-ChIP_Hs578T_Human0.99823927
122RUNX1_22412390_ChIP-Seq_EML_Mouse0.99591038
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99570135
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99494551
125VDR_24787735_ChIP-Seq_THP-1_Human0.99375117
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97567285
127RAC3_21632823_ChIP-Seq_H3396_Human0.97505076
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97221749
129VDR_24763502_ChIP-Seq_THP-1_Human0.97001297
130ELK1_22589737_ChIP-Seq_MCF10A_Human0.96862634
131* FOXA1_25329375_ChIP-Seq_VCAP_Human0.96817723
132* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96817723
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96521692
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95947065
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95912886
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95865973
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95678049
138* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95616485
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.95377500
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94482642
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94361413
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94348328
143* AR_20517297_ChIP-Seq_VCAP_Human0.93893966
144TP53_22573176_ChIP-Seq_HFKS_Human0.92232140
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92106407
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91600119
147PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91412211
148* BCL6_27268052_Chip-Seq_Bcells_Human0.91250558
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91231047
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90277661
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90254676
152SMRT_27268052_Chip-Seq_Bcells_Human0.90071807
153* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89822270
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89505893
155MYC_19829295_ChIP-Seq_ESCs_Human0.88794439
156* SPI1_20517297_ChIP-Seq_HL60_Human0.88397877
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88382590
158ERA_21632823_ChIP-Seq_H3396_Human0.87332316
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86566528
160OCT4_20526341_ChIP-Seq_ESCs_Human0.86429673
161SMAD_19615063_ChIP-ChIP_OVARY_Human0.85933106
162* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84969282
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.82722740
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82658568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.68184860
2MP0003806_abnormal_nucleotide_metabolis3.67859830
3MP0009840_abnormal_foam_cell3.46229465
4MP0005623_abnormal_meninges_morphology3.35767502
5MP0005360_urolithiasis2.86154781
6MP0005365_abnormal_bile_salt2.72335415
7MP0005085_abnormal_gallbladder_physiolo2.69208243
8MP0009785_altered_susceptibility_to2.60162107
9MP0003186_abnormal_redox_activity2.52220213
10MP0003191_abnormal_cellular_cholesterol2.47112316
11MP0001835_abnormal_antigen_presentation2.40949860
12MP0003436_decreased_susceptibility_to2.26201059
13MP0003693_abnormal_embryo_hatching2.00266650
14MP0003724_increased_susceptibility_to1.99153232
15MP0008875_abnormal_xenobiotic_pharmacok1.98348062
16MP0005058_abnormal_lysosome_morphology1.92935370
17MP0000685_abnormal_immune_system1.84943260
18MP0003195_calcinosis1.82848836
19MP0005025_abnormal_response_to1.79420978
20MP0005332_abnormal_amino_acid1.79035240
21MP0000750_abnormal_muscle_regeneration1.78021911
22MP0005397_hematopoietic_system_phenotyp1.73771417
23MP0001545_abnormal_hematopoietic_system1.73771417
24MP0002277_abnormal_respiratory_mucosa1.70999737
25MP0002148_abnormal_hypersensitivity_rea1.69707302
26MP0010329_abnormal_lipoprotein_level1.62679184
27MP0005319_abnormal_enzyme/_coenzyme1.62482178
28MP0009333_abnormal_splenocyte_physiolog1.58464888
29MP0003656_abnormal_erythrocyte_physiolo1.55540205
30MP0002419_abnormal_innate_immunity1.55510634
31MP0008469_abnormal_protein_level1.55406418
32MP0000609_abnormal_liver_physiology1.54392061
33MP0006082_CNS_inflammation1.53484892
34MP0001853_heart_inflammation1.52262737
35MP0006036_abnormal_mitochondrial_physio1.48251373
36MP0005464_abnormal_platelet_physiology1.44120335
37MP0005671_abnormal_response_to1.44105888
38MP0002138_abnormal_hepatobiliary_system1.43856358
39MP0003300_gastrointestinal_ulcer1.41873273
40MP0005083_abnormal_biliary_tract1.41261475
41MP0001764_abnormal_homeostasis1.41100505
42MP0005000_abnormal_immune_tolerance1.40703899
43MP0009764_decreased_sensitivity_to1.38259710
44MP0004957_abnormal_blastocyst_morpholog1.37119613
45MP0003718_maternal_effect1.33895296
46MP0002723_abnormal_immune_serum1.32379260
47MP0001845_abnormal_inflammatory_respons1.29000617
48MP0003866_abnormal_defecation1.28852496
49MP0002452_abnormal_antigen_presenting1.27809672
50MP0004510_myositis1.26831095
51MP0000858_altered_metastatic_potential1.26468089
52MP0001790_abnormal_immune_system1.25020360
53MP0005387_immune_system_phenotype1.25020360
54MP0002254_reproductive_system_inflammat1.23102243
55MP0001800_abnormal_humoral_immune1.21756695
56MP0003075_altered_response_to1.21573200
57MP0004019_abnormal_vitamin_homeostasis1.19683254
58MP0005451_abnormal_body_composition1.16926467
59MP0001873_stomach_inflammation1.16523181
60MP0003045_fibrosis1.16501037
61MP0002876_abnormal_thyroid_physiology1.16024641
62MP0000598_abnormal_liver_morphology1.15005118
63MP0003646_muscle_fatigue1.13935692
64MP0001819_abnormal_immune_cell1.13732465
65MP0005584_abnormal_enzyme/coenzyme_acti1.13621112
66MP0009643_abnormal_urine_homeostasis1.13574835
67MP0004782_abnormal_surfactant_physiolog1.13418389
68MP0001666_abnormal_nutrient_absorption1.13300115
69MP0004947_skin_inflammation1.12915452
70MP0003252_abnormal_bile_duct1.12107865
71MP0005166_decreased_susceptibility_to1.11216244
72MP0002420_abnormal_adaptive_immunity1.10997871
73MP0010155_abnormal_intestine_physiology1.10445118
74MP0003448_altered_tumor_morphology1.10313243
75MP0002163_abnormal_gland_morphology1.07369826
76MP0002006_tumorigenesis1.05411259
77MP0002118_abnormal_lipid_homeostasis1.05149349
78MP0000343_altered_response_to1.04411159
79MP0006035_abnormal_mitochondrial_morpho1.04156656
80MP0000013_abnormal_adipose_tissue1.03325588
81MP0009763_increased_sensitivity_to1.03211578
82MP0003111_abnormal_nucleus_morphology1.02471790
83MP0003786_premature_aging1.01995880
84MP0000689_abnormal_spleen_morphology1.01396361
85MP0005164_abnormal_response_to0.99774397
86MP0008260_abnormal_autophagy0.98484044
87MP0000490_abnormal_crypts_of0.98143502
88MP0001533_abnormal_skeleton_physiology0.97908880
89MP0002398_abnormal_bone_marrow0.96390704
90MP0002722_abnormal_immune_system0.95310340
91MP0000716_abnormal_immune_system0.95266817
92MP0009278_abnormal_bone_marrow0.94110951
93MP0002396_abnormal_hematopoietic_system0.93548124
94MP0002429_abnormal_blood_cell0.93515438
95MP0009765_abnormal_xenobiotic_induced0.93475361
96MP0002933_joint_inflammation0.92862884
97MP0009697_abnormal_copulation0.92749886
98MP0000604_amyloidosis0.91572659
99MP0002166_altered_tumor_susceptibility0.90985523
100MP0002405_respiratory_system_inflammati0.90398798
101MP0005167_abnormal_blood-brain_barrier0.90337807
102MP0001986_abnormal_taste_sensitivity0.90221973
103MP0004147_increased_porphyrin_level0.89569626
104MP0005379_endocrine/exocrine_gland_phen0.88470711
105MP0003566_abnormal_cell_adhesion0.88312643
106MP0002132_abnormal_respiratory_system0.87792591
107MP0010352_gastrointestinal_tract_polyps0.86417823
108MP0003011_delayed_dark_adaptation0.86138943
109MP0003705_abnormal_hypodermis_morpholog0.84760890
110MP0005376_homeostasis/metabolism_phenot0.83357581
111MP0003221_abnormal_cardiomyocyte_apopto0.82958036
112MP0005266_abnormal_metabolism0.81993844
113MP0003303_peritoneal_inflammation0.81359025
114MP0003763_abnormal_thymus_physiology0.80428662
115MP0002837_dystrophic_cardiac_calcinosis0.79661638
116MP0005636_abnormal_mineral_homeostasis0.79613296
117MP0000358_abnormal_cell_content/0.79043633
118MP0001501_abnormal_sleep_pattern0.77638545
119MP0003077_abnormal_cell_cycle0.76733972
120MP0005310_abnormal_salivary_gland0.76600297
121MP0009384_cardiac_valve_regurgitation0.76492860
122MP0002019_abnormal_tumor_incidence0.76244474
123MP0002877_abnormal_melanocyte_morpholog0.75682612
124MP0005670_abnormal_white_adipose0.75227699
125MP0004883_abnormal_blood_vessel0.74876005
126MP0005023_abnormal_wound_healing0.74735366
127MP0005395_other_phenotype0.73927447
128MP0001663_abnormal_digestive_system0.72533655
129MP0002693_abnormal_pancreas_physiology0.72360802
130MP0002638_abnormal_pupillary_reflex0.71771613
131MP0008873_increased_physiological_sensi0.71442649
132MP0003690_abnormal_glial_cell0.68749199
133MP0010307_abnormal_tumor_latency0.68452712
134MP0003172_abnormal_lysosome_physiology0.67507523
135MP0002332_abnormal_exercise_endurance0.67011531
136MP0008874_decreased_physiological_sensi0.66653470
137MP0005410_abnormal_fertilization0.64555323
138MP0005165_increased_susceptibility_to0.63540204
139MP0005551_abnormal_eye_electrophysiolog0.63526538

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)7.62409837
2Cerebellar dysplasia (HP:0007033)6.47668772
3Type II lissencephaly (HP:0007260)6.28082616
4Hypoplasia of the pons (HP:0012110)5.59738721
5Decreased electroretinogram (ERG) amplitude (HP:0000654)5.41644700
6Fatigue (HP:0012378)5.31944413
7Retinal dysplasia (HP:0007973)5.26658906
8Abnormality of the pons (HP:0007361)5.22616254
9Abolished electroretinogram (ERG) (HP:0000550)4.15312475
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.00620496
11Buphthalmos (HP:0000557)3.77984582
12Difficulty climbing stairs (HP:0003551)3.74361276
13Optic neuritis (HP:0100653)3.69500926
14Retrobulbar optic neuritis (HP:0100654)3.69500926
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69186212
16IgG deficiency (HP:0004315)3.60879362
17Stomatitis (HP:0010280)3.59588508
18Hyperglycinemia (HP:0002154)3.51259976
19Orchitis (HP:0100796)3.49340944
20Myositis (HP:0100614)3.49223733
21Multiple enchondromatosis (HP:0005701)3.35925801
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29929225
23Hyperglycinuria (HP:0003108)3.18626964
24Severe muscular hypotonia (HP:0006829)3.12430677
25Prolonged partial thromboplastin time (HP:0003645)3.06219945
26Recurrent gram-negative bacterial infections (HP:0005420)3.00388273
27Xanthomatosis (HP:0000991)2.97348955
28T lymphocytopenia (HP:0005403)2.97108050
29Abnormality of liposaccharide metabolism (HP:0010968)2.95926679
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.95926679
31Abnormality of glycolipid metabolism (HP:0010969)2.95926679
32Intrahepatic cholestasis (HP:0001406)2.93798140
33Hypobetalipoproteinemia (HP:0003563)2.90166635
34Abnormality of T cell number (HP:0011839)2.88314435
35Abnormality of serine family amino acid metabolism (HP:0010894)2.82402356
36Abnormality of glycine metabolism (HP:0010895)2.82402356
37Hyperammonemia (HP:0001987)2.78612593
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.78455822
39Encephalitis (HP:0002383)2.76847367
40Recurrent abscess formation (HP:0002722)2.76625639
41Nausea (HP:0002018)2.73658374
42Recurrent bacterial skin infections (HP:0005406)2.69408432
43Increased IgM level (HP:0003496)2.61902104
44Polycythemia (HP:0001901)2.60570038
45Eosinophilia (HP:0001880)2.59435807
46Abnormality of serum amino acid levels (HP:0003112)2.57480260
47Petechiae (HP:0000967)2.56306064
48Keratitis (HP:0000491)2.55424170
49Elevated erythrocyte sedimentation rate (HP:0003565)2.54805619
50Abnormality of macrophages (HP:0004311)2.53835498
51Deep venous thrombosis (HP:0002625)2.52949084
52Recurrent fungal infections (HP:0002841)2.52471397
53Pustule (HP:0200039)2.52102166
54Eczematoid dermatitis (HP:0000976)2.50620014
55Abnormality of fatty-acid metabolism (HP:0004359)2.45987315
56Increased serum ferritin (HP:0003281)2.44754030
57Vacuolated lymphocytes (HP:0001922)2.44150328
58Hemoptysis (HP:0002105)2.41253734
59Hypoglycemic coma (HP:0001325)2.40560556
60Keratoconjunctivitis (HP:0001096)2.40008620
61Mediastinal lymphadenopathy (HP:0100721)2.39471379
62Keratoconjunctivitis sicca (HP:0001097)2.37799180
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37610552
64Dicarboxylic aciduria (HP:0003215)2.37610552
65Leukocytosis (HP:0001974)2.37420023
66Hyperlipoproteinemia (HP:0010980)2.37181341
67Abnormality of the intrinsic pathway (HP:0010989)2.36776939
68Autoimmune thrombocytopenia (HP:0001973)2.36671962
69Mesangial abnormality (HP:0001966)2.35676228
70Hepatic necrosis (HP:0002605)2.35553598
71Lethargy (HP:0001254)2.35534366
72Pulmonary infiltrates (HP:0002113)2.35521613
73Abnormality of pyrimidine metabolism (HP:0004353)2.35079592
74Vasculitis (HP:0002633)2.33703472
75Granulocytopenia (HP:0001913)2.32956920
76Joint hemorrhage (HP:0005261)2.32791895
77Abnormality of eosinophils (HP:0001879)2.30835222
78Abnormality of T cells (HP:0002843)2.30470961
79Abnormality of the common coagulation pathway (HP:0010990)2.30305973
80Abnormality of cells of the erythroid lineage (HP:0012130)2.28736408
81Anorexia (HP:0002039)2.28676619
82Entropion (HP:0000621)2.28397571
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28275033
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28275033
85Abnormality of iron homeostasis (HP:0011031)2.28195058
86Systemic lupus erythematosus (HP:0002725)2.27779011
87Hypergammaglobulinemia (HP:0010702)2.27144022
88Purpura (HP:0000979)2.26673254
89Meningitis (HP:0001287)2.25415341
90Hypolipoproteinemia (HP:0010981)2.24105772
91Abnormality of the nasal mucosa (HP:0000433)2.22064567
92Abnormal cartilage morphology (HP:0002763)2.21565303
93Myocardial infarction (HP:0001658)2.21371357
94Abnormality of transition element cation homeostasis (HP:0011030)2.20310597
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.19784899
96Recurrent bronchitis (HP:0002837)2.18976710
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.16598619
98Thrombocytosis (HP:0001894)2.15912883
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15450586
100Gingival bleeding (HP:0000225)2.15377171
101Vertebral compression fractures (HP:0002953)2.15282306
102Tetraparesis (HP:0002273)2.14646806
103Congenital glaucoma (HP:0001087)2.13888856
104Abnormal number of erythroid precursors (HP:0012131)2.13143273
105Nasal polyposis (HP:0100582)2.12877833
106Chronic obstructive pulmonary disease (HP:0006510)2.12140538
107Obstructive lung disease (HP:0006536)2.12140538
108Axonal loss (HP:0003447)2.12020445
109Progressive muscle weakness (HP:0003323)2.11181006
110Reduced antithrombin III activity (HP:0001976)2.10003169
111Poor head control (HP:0002421)2.09416938
112Recurrent cutaneous fungal infections (HP:0011370)2.03779941
113Chronic mucocutaneous candidiasis (HP:0002728)2.03779941
114Gangrene (HP:0100758)2.03487887
115Lissencephaly (HP:0001339)2.02735871
116Joint swelling (HP:0001386)2.02695913
117Hypochromic anemia (HP:0001931)2.01868842
118Gastrointestinal infarctions (HP:0005244)2.01816404
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01364569
120Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00987238
121Abnormality of polysaccharide metabolism (HP:0011012)2.00987238
122Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00987238
123Gout (HP:0001997)2.00684812
124Generalized aminoaciduria (HP:0002909)2.00229646
125Prolonged neonatal jaundice (HP:0006579)1.99869816
126Abnormality of methionine metabolism (HP:0010901)1.99552809
127Hyperbilirubinemia (HP:0002904)1.99373464
128Urticaria (HP:0001025)1.98516636
129Complement deficiency (HP:0004431)1.97137028
130Abnormality of vision evoked potentials (HP:0000649)1.96082528
131Increased cerebral lipofuscin (HP:0011813)1.95977069
132Microcytic anemia (HP:0001935)1.95969232
133Cerebral edema (HP:0002181)1.95499190
134Chronic otitis media (HP:0000389)1.94923425
135Exertional dyspnea (HP:0002875)1.93400523
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92921885
137Hypoalphalipoproteinemia (HP:0003233)1.92814912
138Epistaxis (HP:0000421)1.92530374
139Fat malabsorption (HP:0002630)1.92229456
140Hepatocellular necrosis (HP:0001404)1.91935291
1413-Methylglutaconic aciduria (HP:0003535)1.91497677
142Ketosis (HP:0001946)1.91253623
143Abnormality of nucleobase metabolism (HP:0010932)1.91042629
144Abnormality of the heme biosynthetic pathway (HP:0010472)1.90373163
145Esophageal varix (HP:0002040)1.87306952
146Megalocornea (HP:0000485)1.87112255
147Interstitial pulmonary disease (HP:0006530)1.84963323
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.83512273
149Recurrent viral infections (HP:0004429)1.83412789
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83379807
151Severe global developmental delay (HP:0011344)1.82884233
152Hematochezia (HP:0002573)1.82800270
153Mucopolysacchariduria (HP:0008155)1.82640527
154Urinary glycosaminoglycan excretion (HP:0003541)1.82640527
155Basal ganglia calcification (HP:0002135)1.81231854
156Erythroderma (HP:0001019)1.80958527
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80511442
158Increased muscle lipid content (HP:0009058)1.80078206
159Pulmonary embolism (HP:0002204)1.79970545
160Abnormality of T cell physiology (HP:0011840)1.79890017
161CNS demyelination (HP:0007305)1.78882762
162Rough bone trabeculation (HP:0100670)1.78335221
163Rhabdomyolysis (HP:0003201)1.78227808
164Acute hepatic failure (HP:0006554)1.78031117
165Generalized muscle weakness (HP:0003324)1.77312040
166Hypoalbuminemia (HP:0003073)1.76580845
167Abnormal albumin level (HP:0012116)1.76580845
168Recurrent skin infections (HP:0001581)1.76091271
169IgA deficiency (HP:0002720)1.76034218
170Episodic fever (HP:0001954)1.75950386
171Abnormality of the pleura (HP:0002103)1.75820868
172Spontaneous abortion (HP:0005268)1.74978373
173Intellectual disability, profound (HP:0002187)1.74396338
174Myopathic facies (HP:0002058)1.74385614
175Lactic acidosis (HP:0003128)1.74272172
176Gowers sign (HP:0003391)1.73864232
177Abnormality of DNA repair (HP:0003254)1.73363326
178Pachygyria (HP:0001302)1.72315526
179Polyneuropathy (HP:0001271)1.71854097
180Autoimmune hemolytic anemia (HP:0001890)1.70444092
181Chronic diarrhea (HP:0002028)1.68520634
182Poikiloderma (HP:0001029)1.68056346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.49337682
2BCKDK3.69145250
3PIM22.95583376
4ERN12.75462722
5WEE12.50961133
6EIF2AK12.49065100
7BUB12.39523033
8EIF2AK32.30236907
9TYK22.28770752
10TBK12.25788115
11ADRBK22.14647726
12TAOK31.99382924
13EPHA21.90220802
14KDR1.81801114
15IRAK31.79728724
16GRK71.74884626
17PTK2B1.73685926
18MAP3K141.71089190
19TRIB31.69797998
20IKBKB1.66643701
21FRK1.65384737
22ZAP701.62873669
23EPHA31.62227353
24STK111.61798659
25ARAF1.60509688
26MAP4K21.60483845
27FLT31.52860811
28FGFR41.51349345
29BMPR21.49574051
30MAP4K11.49105097
31BLK1.47661141
32ACVR1B1.43040109
33RPS6KA41.42211963
34JAK31.40965642
35MAP2K31.36673299
36IKBKE1.33579385
37PIK3CG1.32039498
38NEK11.31068746
39KIT1.29777410
40STK161.27126551
41BRSK21.26976757
42ABL21.26035304
43TNK21.25458563
44PIM11.23656091
45ITK1.22229378
46MAP3K31.21798362
47IRAK11.21286144
48TAOK11.19236858
49LCK1.17074879
50NEK21.16850304
51LRRK21.10177706
52MAP3K111.09628400
53DYRK31.08374177
54FES1.07796825
55IRAK41.06950655
56PINK11.05328200
57NEK91.05275410
58RIPK41.04930155
59DAPK21.00182161
60TESK20.99182992
61PDK40.98110337
62PDK30.98110337
63EPHB10.97941545
64PDK20.96093989
65STK100.90908941
66PRKCQ0.88578888
67TAOK20.88489037
68MAPK110.87658341
69GRK10.85688851
70MATK0.85468136
71LMTK20.83975833
72MYLK0.83884103
73TIE10.83394559
74MAPKAPK30.82768551
75HCK0.80292315
76AKT30.79935244
77MAP3K130.79627405
78TSSK60.79105741
79PKN20.78283758
80TGFBR20.77087160
81TLK10.75945420
82RPS6KB20.74974129
83EIF2AK20.73990569
84CSK0.73931686
85MAP3K80.72461671
86NLK0.72224235
87CDK40.71857710
88MAP2K60.71642599
89STK40.71151885
90BTK0.70235624
91SYK0.70225552
92TESK10.69760120
93BRAF0.68864812
94PRKCH0.68327705
95FGR0.68312026
96CDK190.67527578
97ILK0.66234120
98CLK10.65567703
99MST40.65530686
100MAP3K100.65171649
101PLK10.62995051
102PAK40.62928328
103CHUK0.62860898
104TGFBR10.62490362
105MAP3K50.61859995
106PBK0.61118667
107JAK10.60272066
108TEC0.58739300
109JAK20.55487153
110GRK60.54062642
111TXK0.53647961
112PLK40.52617535
113LYN0.52527487
114AURKB0.52434518
115VRK10.51661560
116PIK3CA0.51416513
117HIPK20.51405817
118CSF1R0.48074641
119MARK30.47827668
120DAPK30.46717971
121WNK40.46086448
122ZAK0.44891418
123MAP2K20.44283588
124CSNK2A10.43779795
125PAK10.43423694
126PRKCD0.43171266
127IRAK20.42120491
128TTN0.41545609
129NUAK10.41102867
130RPS6KA60.40493290
131PDK10.40484397
132RPS6KA50.39308348
133PRKD20.39254732
134MAP3K10.39130005
135FGFR30.38121216
136MUSK0.35916929
137CAMKK20.35906606
138OXSR10.34541591
139FYN0.32554449
140PKN10.32357952
141MAPK150.30331089
142IGF1R0.28656056
143ABL10.28517117
144ADRBK10.28002241
145PRKG20.27496630
146MAP2K70.26300655
147PDPK10.24459078

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.22211542
2Autoimmune thyroid disease_Homo sapiens_hsa053203.17951238
3Type I diabetes mellitus_Homo sapiens_hsa049402.81824003
4Primary immunodeficiency_Homo sapiens_hsa053402.79933700
5Asthma_Homo sapiens_hsa053102.77953250
6Ribosome_Homo sapiens_hsa030102.31592867
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29916015
8Rheumatoid arthritis_Homo sapiens_hsa053232.22157364
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21550766
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.18940947
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.13244019
12Folate biosynthesis_Homo sapiens_hsa007902.12623673
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10986097
14Osteoclast differentiation_Homo sapiens_hsa043802.02791432
15RNA polymerase_Homo sapiens_hsa030202.01230964
16Sulfur relay system_Homo sapiens_hsa041221.98065085
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96792120
18Vitamin B6 metabolism_Homo sapiens_hsa007501.91858633
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81793571
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78522532
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74170886
22TNF signaling pathway_Homo sapiens_hsa046681.72824122
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70368147
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.69798834
25Staphylococcus aureus infection_Homo sapiens_hsa051501.68962169
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66517552
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66073259
28Pentose phosphate pathway_Homo sapiens_hsa000301.65880546
29DNA replication_Homo sapiens_hsa030301.62276614
30Hematopoietic cell lineage_Homo sapiens_hsa046401.61770208
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58075453
32Pyrimidine metabolism_Homo sapiens_hsa002401.55814218
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53459286
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52870354
35Fatty acid degradation_Homo sapiens_hsa000711.52139659
36Toxoplasmosis_Homo sapiens_hsa051451.52121757
37Mismatch repair_Homo sapiens_hsa034301.49686268
38One carbon pool by folate_Homo sapiens_hsa006701.47959901
39Arginine biosynthesis_Homo sapiens_hsa002201.47539087
40Complement and coagulation cascades_Homo sapiens_hsa046101.46384712
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39409633
42Peroxisome_Homo sapiens_hsa041461.37548265
43Tryptophan metabolism_Homo sapiens_hsa003801.37330816
44Carbon metabolism_Homo sapiens_hsa012001.35686386
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35400773
46Selenocompound metabolism_Homo sapiens_hsa004501.33956594
47Tuberculosis_Homo sapiens_hsa051521.33751929
48Viral myocarditis_Homo sapiens_hsa054161.32033116
49Biosynthesis of amino acids_Homo sapiens_hsa012301.31507475
50Legionellosis_Homo sapiens_hsa051341.31271715
51Sulfur metabolism_Homo sapiens_hsa009201.30959361
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28766079
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27821922
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25701879
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25422927
56Caffeine metabolism_Homo sapiens_hsa002321.22430050
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.20743535
58Fructose and mannose metabolism_Homo sapiens_hsa000511.18981058
59Other glycan degradation_Homo sapiens_hsa005111.18727657
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.18280550
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14761582
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13552309
63Phagosome_Homo sapiens_hsa041451.09882898
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02768466
65Glutathione metabolism_Homo sapiens_hsa004801.02451209
66Phenylalanine metabolism_Homo sapiens_hsa003601.00890892
67Chemical carcinogenesis_Homo sapiens_hsa052040.99399308
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.98026038
69Histidine metabolism_Homo sapiens_hsa003400.96202501
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94592339
71T cell receptor signaling pathway_Homo sapiens_hsa046600.94454214
72Chemokine signaling pathway_Homo sapiens_hsa040620.93955295
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93909393
74Collecting duct acid secretion_Homo sapiens_hsa049660.93905212
75PPAR signaling pathway_Homo sapiens_hsa033200.93055062
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92757734
77Graft-versus-host disease_Homo sapiens_hsa053320.92339869
78Salmonella infection_Homo sapiens_hsa051320.90407464
79Fatty acid metabolism_Homo sapiens_hsa012120.89105324
80beta-Alanine metabolism_Homo sapiens_hsa004100.87901382
81Antigen processing and presentation_Homo sapiens_hsa046120.87391182
82B cell receptor signaling pathway_Homo sapiens_hsa046620.87217255
83Base excision repair_Homo sapiens_hsa034100.86689152
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.86472413
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.85815704
86Leishmaniasis_Homo sapiens_hsa051400.85705242
87Allograft rejection_Homo sapiens_hsa053300.83930825
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83807031
89Galactose metabolism_Homo sapiens_hsa000520.83724520
90Linoleic acid metabolism_Homo sapiens_hsa005910.83529557
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83210736
92Regulation of autophagy_Homo sapiens_hsa041400.81623864
93Hepatitis C_Homo sapiens_hsa051600.81259084
94Lysosome_Homo sapiens_hsa041420.80596430
95Vitamin digestion and absorption_Homo sapiens_hsa049770.80451815
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.78207710
97Homologous recombination_Homo sapiens_hsa034400.76145517
98Herpes simplex infection_Homo sapiens_hsa051680.75508809
99Measles_Homo sapiens_hsa051620.75432871
100RNA transport_Homo sapiens_hsa030130.75205043
101Propanoate metabolism_Homo sapiens_hsa006400.73310925
102Tyrosine metabolism_Homo sapiens_hsa003500.71555562
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70907066
104Nucleotide excision repair_Homo sapiens_hsa034200.70824592
105Pyruvate metabolism_Homo sapiens_hsa006200.70147534
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69454392
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68925652
108Arginine and proline metabolism_Homo sapiens_hsa003300.68044412
109Retinol metabolism_Homo sapiens_hsa008300.67540788
110p53 signaling pathway_Homo sapiens_hsa041150.67157280
111Nitrogen metabolism_Homo sapiens_hsa009100.66914562
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65011500
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64604197
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.63860236
115Fatty acid elongation_Homo sapiens_hsa000620.62437554
116Starch and sucrose metabolism_Homo sapiens_hsa005000.61404913
117Metabolic pathways_Homo sapiens_hsa011000.59916429
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58244090
119Purine metabolism_Homo sapiens_hsa002300.57753325
120Oxidative phosphorylation_Homo sapiens_hsa001900.56177542
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54483164
122Epstein-Barr virus infection_Homo sapiens_hsa051690.53720483
123Pertussis_Homo sapiens_hsa051330.52516146
124Shigellosis_Homo sapiens_hsa051310.51322026
125Apoptosis_Homo sapiens_hsa042100.50860810
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.50810849
127Spliceosome_Homo sapiens_hsa030400.50760456
128Influenza A_Homo sapiens_hsa051640.50425852
129Parkinsons disease_Homo sapiens_hsa050120.50109920
130Malaria_Homo sapiens_hsa051440.49224057
131Fat digestion and absorption_Homo sapiens_hsa049750.49019786
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47892436
133Systemic lupus erythematosus_Homo sapiens_hsa053220.47692994
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46490011
135African trypanosomiasis_Homo sapiens_hsa051430.46423890
136ABC transporters_Homo sapiens_hsa020100.45648542
137Ether lipid metabolism_Homo sapiens_hsa005650.45601500
138Arachidonic acid metabolism_Homo sapiens_hsa005900.41773544
139Mineral absorption_Homo sapiens_hsa049780.37051483
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36655256
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30779168
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30123369
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28293240
144Hepatitis B_Homo sapiens_hsa051610.26419344
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25680314
146Alzheimers disease_Homo sapiens_hsa050100.25120947
147Butanoate metabolism_Homo sapiens_hsa006500.24575808
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.24571636
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23919216
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23919062
151Sphingolipid metabolism_Homo sapiens_hsa006000.18466988
152Huntingtons disease_Homo sapiens_hsa050160.12673232

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