FBXO47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)9.98367993
2regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.45487486
3protein-chromophore linkage (GO:0018298)7.21884178
4DNA synthesis involved in DNA repair (GO:0000731)6.35030555
5lipopolysaccharide biosynthetic process (GO:0009103)6.32644411
6protein localization to kinetochore (GO:0034501)6.05468221
7positive regulation of meiosis (GO:0045836)5.89561152
8sulfate transmembrane transport (GO:1902358)5.54293167
9female gamete generation (GO:0007292)5.50997724
10positive regulation of meiotic cell cycle (GO:0051446)5.47750981
11negative regulation of cell killing (GO:0031342)5.45644189
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45644189
13lipopolysaccharide metabolic process (GO:0008653)5.43941470
14centriole replication (GO:0007099)5.32537604
15paraxial mesoderm development (GO:0048339)5.30406058
16DNA replication checkpoint (GO:0000076)5.29810454
17oogenesis (GO:0048477)5.24371183
18protein localization to chromosome, centromeric region (GO:0071459)5.23495866
19regulation of protein glycosylation (GO:0060049)5.16233544
20piRNA metabolic process (GO:0034587)5.16171084
21negative regulation of glycoprotein biosynthetic process (GO:0010561)5.10292133
22mitotic chromosome condensation (GO:0007076)5.02582408
23positive regulation of developmental pigmentation (GO:0048087)4.94751609
24regulation of pigment cell differentiation (GO:0050932)4.94134522
25nuclear pore complex assembly (GO:0051292)4.90291783
26regulation of nuclear cell cycle DNA replication (GO:0033262)4.90102651
27nuclear pore organization (GO:0006999)4.89090977
28negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.79098262
29regulation of telomere maintenance via telomerase (GO:0032210)4.78625490
30sulfate transport (GO:0008272)4.77370248
31DNA methylation (GO:0006306)4.77213931
32DNA alkylation (GO:0006305)4.77213931
33mitotic sister chromatid segregation (GO:0000070)4.75967818
34regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.75188082
35mitotic metaphase plate congression (GO:0007080)4.68963341
36daunorubicin metabolic process (GO:0044597)4.67676168
37polyketide metabolic process (GO:0030638)4.67676168
38doxorubicin metabolic process (GO:0044598)4.67676168
39synaptonemal complex assembly (GO:0007130)4.67525539
40DNA replication-dependent nucleosome assembly (GO:0006335)4.64538787
41DNA replication-dependent nucleosome organization (GO:0034723)4.64538787
42negative regulation of cell cycle G2/M phase transition (GO:1902750)4.35297657
43synaptonemal complex organization (GO:0070193)4.26832874
44regulation of meiosis I (GO:0060631)4.26474876
45regulation of rhodopsin mediated signaling pathway (GO:0022400)4.22752317
46rRNA methylation (GO:0031167)4.21310747
47rRNA modification (GO:0000154)4.20305066
48rRNA transcription (GO:0009303)4.18148810
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15584277
50somite rostral/caudal axis specification (GO:0032525)4.14057841
51SMAD protein complex assembly (GO:0007183)4.12898735
52histone H4-K12 acetylation (GO:0043983)4.11110935
53ribosome biogenesis (GO:0042254)4.04109096
54sister chromatid segregation (GO:0000819)4.01185220
55spermatid development (GO:0007286)4.00136595
56attachment of spindle microtubules to kinetochore (GO:0008608)3.99459480
57metaphase plate congression (GO:0051310)3.96239395
58centriole assembly (GO:0098534)3.94838476
59heterochromatin organization (GO:0070828)3.86757886
60rhodopsin mediated signaling pathway (GO:0016056)3.86281353
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.85982135
62L-phenylalanine catabolic process (GO:0006559)3.85982135
63male meiosis (GO:0007140)3.80474770
64meiotic chromosome segregation (GO:0045132)3.75465403
65heme transport (GO:0015886)3.73352730
66maintenance of protein location in nucleus (GO:0051457)3.72795639
67histone H4-K5 acetylation (GO:0043981)3.72379783
68histone H4-K8 acetylation (GO:0043982)3.72379783
69negative regulation of glycoprotein metabolic process (GO:1903019)3.66401158
70mitotic nuclear envelope disassembly (GO:0007077)3.65478657
71meiotic nuclear division (GO:0007126)3.63472418
72regulation of mammary gland epithelial cell proliferation (GO:0033599)3.62675825
73pore complex assembly (GO:0046931)3.62538337
74DNA methylation involved in gamete generation (GO:0043046)3.62433335
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.59403732
76protein K6-linked ubiquitination (GO:0085020)3.57661468
77tyrosine metabolic process (GO:0006570)3.57657670
78male meiosis I (GO:0007141)3.57626623
79ribonucleoprotein complex disassembly (GO:0032988)3.56048058
80negative regulation of telomerase activity (GO:0051974)3.55470551
81regulation of meiotic cell cycle (GO:0051445)3.54783407
82regulation of response to osmotic stress (GO:0047484)3.52559308
83negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.51631041
84DNA methylation or demethylation (GO:0044728)3.51211394
85chromosome condensation (GO:0030261)3.48031621
86chromatin assembly (GO:0031497)3.47192394
87regulation of cilium movement (GO:0003352)3.46570040
88negative regulation of epidermis development (GO:0045683)3.45524140
89protein localization to chromosome (GO:0034502)3.42727948
90nuclear envelope disassembly (GO:0051081)3.42001726
91membrane disassembly (GO:0030397)3.42001726
92tachykinin receptor signaling pathway (GO:0007217)3.41958532
93regulation of odontogenesis (GO:0042481)3.40137690
94resolution of meiotic recombination intermediates (GO:0000712)3.40038867
95germ cell development (GO:0007281)3.39527006
96chromosome organization involved in meiosis (GO:0070192)3.38207583
97regulation of gene silencing by RNA (GO:0060966)3.38190343
98regulation of posttranscriptional gene silencing (GO:0060147)3.38190343
99regulation of gene silencing by miRNA (GO:0060964)3.38190343
100L-phenylalanine metabolic process (GO:0006558)3.34993296
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34993296
102meiosis I (GO:0007127)3.34919307
103organelle disassembly (GO:1903008)3.34476774
104toxin metabolic process (GO:0009404)3.33079960
105muscle organ morphogenesis (GO:0048644)3.28283270
106regulation of double-strand break repair via homologous recombination (GO:0010569)3.28269024
107regulation of isotype switching to IgG isotypes (GO:0048302)3.28169257
108establishment of chromosome localization (GO:0051303)3.28029684
109DNA replication initiation (GO:0006270)3.27492289
110DNA packaging (GO:0006323)3.25669061
111regulation of translation in response to stress (GO:0043555)3.23076888
112negative regulation of telomere maintenance (GO:0032205)3.21526586
113regulation of chromosome segregation (GO:0051983)3.21489516
114notochord development (GO:0030903)3.21086306
115genitalia morphogenesis (GO:0035112)3.20883263
116meiotic cell cycle process (GO:1903046)3.20188398
117fertilization (GO:0009566)3.19890139
118histone exchange (GO:0043486)3.19359543
119chromatin remodeling at centromere (GO:0031055)3.19203646
120regulation of meiosis (GO:0040020)3.19171925
121reciprocal meiotic recombination (GO:0007131)3.16962918
122reciprocal DNA recombination (GO:0035825)3.16962918
123gene silencing by RNA (GO:0031047)3.14410699
124DNA damage response, signal transduction resulting in transcription (GO:0042772)3.12330325
125regulation of spindle organization (GO:0090224)3.11570772
126spindle checkpoint (GO:0031577)3.10801080
127regulation of interleukin-5 production (GO:0032674)3.10207424
128negative regulation of stem cell proliferation (GO:2000647)3.10034175
129regulation of double-strand break repair (GO:2000779)3.08668650
130serotonin receptor signaling pathway (GO:0007210)3.08397035
131chromosome segregation (GO:0007059)3.08008314
132CENP-A containing nucleosome assembly (GO:0034080)3.07129429
133nodal signaling pathway (GO:0038092)3.03931605
134DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.02983984
135chromatin assembly or disassembly (GO:0006333)3.02909964
136cytidine deamination (GO:0009972)3.02158877
137cytidine metabolic process (GO:0046087)3.02158877
138cytidine catabolic process (GO:0006216)3.02158877
139intestinal epithelial cell development (GO:0060576)3.01712643
140DNA replication-independent nucleosome assembly (GO:0006336)3.00307538
141DNA replication-independent nucleosome organization (GO:0034724)3.00307538
142regulation of transforming growth factor beta2 production (GO:0032909)2.98592959
143DNA modification (GO:0006304)2.95047119
144spindle assembly checkpoint (GO:0071173)2.94585905
145mitotic G2/M transition checkpoint (GO:0044818)2.94576373
146germinal center formation (GO:0002467)2.94408246
147histone H2A monoubiquitination (GO:0035518)2.94392158
148male gamete generation (GO:0048232)2.94335090
149positive regulation of chromosome segregation (GO:0051984)2.94196006
150spermatogenesis (GO:0007283)2.94098402
151meiotic cell cycle (GO:0051321)2.93843576
152DNA damage induced protein phosphorylation (GO:0006975)2.93802834
153positive regulation of DNA-dependent DNA replication (GO:2000105)2.93584799
154sister chromatid cohesion (GO:0007062)2.92923734
155cellular response to gamma radiation (GO:0071480)2.92716229
156sperm motility (GO:0030317)2.91924851
157flavonoid metabolic process (GO:0009812)2.91754578
158spindle assembly (GO:0051225)2.89564873
159regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89430036
160glycerol metabolic process (GO:0006071)2.87416803
161sulfur compound transport (GO:0072348)2.87312747
162gamete generation (GO:0007276)2.85422417
163epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85260594
164iron coordination entity transport (GO:1901678)2.85103563
165heart valve formation (GO:0003188)2.81082913
166aromatic amino acid family catabolic process (GO:0009074)2.79573915
167vitamin transmembrane transport (GO:0035461)2.79356588
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.74609542
169indolalkylamine metabolic process (GO:0006586)2.74052454
170protein retention in ER lumen (GO:0006621)2.64745697
171left/right axis specification (GO:0070986)2.63400688
172response to mercury ion (GO:0046689)2.61158223
173sphingosine metabolic process (GO:0006670)12.3124480
174diol metabolic process (GO:0034311)11.2464122
175synapsis (GO:0007129)10.4433458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13462624
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75298388
3EZH2_22144423_ChIP-Seq_EOC_Human4.44370289
4IGF1R_20145208_ChIP-Seq_DFB_Human4.06306279
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88337335
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.75258937
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.71554089
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.71554089
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.71554089
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.67084161
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.53957574
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44194992
13AR_21572438_ChIP-Seq_LNCaP_Human3.37586084
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92453722
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.84604871
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.76590364
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62121113
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.50671644
19VDR_22108803_ChIP-Seq_LS180_Human2.48728456
20AR_21909140_ChIP-Seq_LNCAP_Human2.42614033
21ER_23166858_ChIP-Seq_MCF-7_Human2.39788296
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23846444
23P300_19829295_ChIP-Seq_ESCs_Human2.19865587
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14067076
25ZNF274_21170338_ChIP-Seq_K562_Hela2.13976906
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10744550
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.06870347
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06265092
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05082109
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03258321
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01918280
32GBX2_23144817_ChIP-Seq_PC3_Human1.96022741
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93664275
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.92733055
35HOXB7_26014856_ChIP-Seq_BT474_Human1.89307988
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85987341
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85315671
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84574614
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80307051
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77204305
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76603482
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76233729
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75424222
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.75424222
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75297152
46* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74961462
47TCF4_23295773_ChIP-Seq_U87_Human1.73103075
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72764205
49* NANOG_19829295_ChIP-Seq_ESCs_Human1.72639947
50* SOX2_19829295_ChIP-Seq_ESCs_Human1.72639947
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67845470
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66582364
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.66554948
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66360520
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63696880
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.62991399
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62039320
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60952767
59* STAT3_23295773_ChIP-Seq_U87_Human1.59888455
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.58250741
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56897855
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56613587
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.54364067
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54184616
65* AR_25329375_ChIP-Seq_VCAP_Human1.52392385
66FUS_26573619_Chip-Seq_HEK293_Human1.51303765
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49425799
68CBP_20019798_ChIP-Seq_JUKART_Human1.49425799
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.49376850
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.49336695
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49099820
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48520978
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47692925
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47491942
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46540136
76MYC_22102868_ChIP-Seq_BL_Human1.46394895
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45767683
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.44762157
79FOXP3_21729870_ChIP-Seq_TREG_Human1.39448247
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.38429754
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.37755255
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.37662944
83VDR_23849224_ChIP-Seq_CD4+_Human1.36892471
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36807199
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34939827
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33975865
87SMAD4_21799915_ChIP-Seq_A2780_Human1.33674615
88KDM5A_27292631_Chip-Seq_BREAST_Human1.33560446
89* OCT4_20526341_ChIP-Seq_ESCs_Human1.33286919
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.33110089
91XRN2_22483619_ChIP-Seq_HELA_Human1.31472247
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.31442883
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30529691
94* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29962664
95* FOXA1_25329375_ChIP-Seq_VCAP_Human1.29962664
96NCOR_22424771_ChIP-Seq_293T_Human1.28449993
97* PRDM14_20953172_ChIP-Seq_ESCs_Human1.28310930
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26658922
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26610487
100TAF15_26573619_Chip-Seq_HEK293_Human1.25746841
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25569587
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24708072
103GABP_19822575_ChIP-Seq_HepG2_Human1.24687119
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.24283064
105WDR5_24793694_ChIP-Seq_LNCAP_Human1.24021895
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23591177
107IRF1_19129219_ChIP-ChIP_H3396_Human1.23074671
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23039158
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22376115
110* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21387529
111BCAT_22108803_ChIP-Seq_LS180_Human1.21267570
112MYC_19829295_ChIP-Seq_ESCs_Human1.21033021
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19358247
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.19308245
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18599496
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.18322020
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.17714561
118RNF2_27304074_Chip-Seq_NSC_Mouse1.16692775
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16468490
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16436814
121CDX2_22108803_ChIP-Seq_LS180_Human1.14635071
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14202579
123KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14140506
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.14050101
125EGR1_19032775_ChIP-ChIP_M12_Human1.13217887
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12822842
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.12729244
128* RUNX2_22187159_ChIP-Seq_PCA_Human1.11786510
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.11428036
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11271531
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11206571
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10721975
133STAT3_18555785_ChIP-Seq_MESCs_Mouse1.10531283
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09524393
135POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09492927
136* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09172775
137POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08736827
138GATA3_26560356_Chip-Seq_TH1_Human1.08542590
139ERA_21632823_ChIP-Seq_H3396_Human1.08115781
140CEBPB_22108803_ChIP-Seq_LS180_Human1.07591880
141TP53_22573176_ChIP-Seq_HFKS_Human1.07341103
142FOXH1_21741376_ChIP-Seq_EPCs_Human1.07206743
143STAT1_17558387_ChIP-Seq_HELA_Human1.06983410
144* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05281050
145* RAC3_21632823_ChIP-Seq_H3396_Human1.04933806
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04915959
147FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04196470
148* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03648605
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03642290
150* TCF4_22108803_ChIP-Seq_LS180_Human1.03383349
151EED_16625203_ChIP-ChIP_MESCs_Mouse1.03000441
152P53_21459846_ChIP-Seq_SAOS-2_Human1.02356260
153AR_19668381_ChIP-Seq_PC3_Human1.02350241
154NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01538494
155FOXH1_21741376_ChIP-Seq_ESCs_Human1.01306267
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01155961
157RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01065067
158E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00682686
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00417989
160* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99837411
161TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99179500
162PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98300711
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.97744716
164CBP_21632823_ChIP-Seq_H3396_Human0.97586472
165CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97212893
166TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97080025
167ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96566408
168SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94824886
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94161663
170ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94069080
171SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93676949
172CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92972387
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89592052
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89437347
175* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88837061
176TTF2_22483619_ChIP-Seq_HELA_Human0.87488778
177HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87099571
178PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86951901
179ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86901318
180NANOG_16518401_ChIP-PET_MESCs_Mouse0.85653649
181DCP1A_22483619_ChIP-Seq_HELA_Human0.82783056
182DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82697642
183ELK1_19687146_ChIP-ChIP_HELA_Human0.82654397
184KAP1_27257070_Chip-Seq_ESCs_Mouse0.81190482
185HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80628335
186* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80605317
187NANOG_16153702_ChIP-ChIP_HESCs_Human0.80343244
188SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79752346
189GATA1_26923725_Chip-Seq_HPCs_Mouse0.79299414
190MYB_26560356_Chip-Seq_TH1_Human0.77564973
191FLI1_27457419_Chip-Seq_LIVER_Mouse0.77290922
192SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74784885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.16371106
2MP0002837_dystrophic_cardiac_calcinosis7.71002657
3MP0005171_absent_coat_pigmentation6.32587489
4MP0003646_muscle_fatigue4.63396837
5MP0008057_abnormal_DNA_replication4.20330405
6MP0004957_abnormal_blastocyst_morpholog3.77404292
7MP0003693_abnormal_embryo_hatching3.63460017
8MP0008877_abnormal_DNA_methylation3.59056198
9MP0003045_fibrosis3.58444938
10MP0003879_abnormal_hair_cell3.41800334
11MP0006292_abnormal_olfactory_placode3.39016008
12MP0010094_abnormal_chromosome_stability3.38159153
13MP0000569_abnormal_digit_pigmentation3.31665152
14MP0003111_abnormal_nucleus_morphology3.16459746
15MP0003077_abnormal_cell_cycle3.06521074
16MP0004264_abnormal_extraembryonic_tissu2.96451572
17MP0003890_abnormal_embryonic-extraembry2.64101538
18MP0005670_abnormal_white_adipose2.60003213
19MP0006082_CNS_inflammation2.39512668
20MP0003123_paternal_imprinting2.35446740
21MP0008058_abnormal_DNA_repair2.32751453
22MP0002138_abnormal_hepatobiliary_system2.28388134
23MP0008007_abnormal_cellular_replicative2.25851694
24MP0003011_delayed_dark_adaptation2.21349057
25MP0003121_genomic_imprinting2.13911334
26MP0010352_gastrointestinal_tract_polyps2.13415204
27MP0005085_abnormal_gallbladder_physiolo2.11095569
28MP0001672_abnormal_embryogenesis/_devel2.05880425
29MP0005380_embryogenesis_phenotype2.05880425
30MP0001929_abnormal_gametogenesis2.01972460
31MP0001730_embryonic_growth_arrest1.99556287
32MP0002132_abnormal_respiratory_system1.98285028
33MP0002653_abnormal_ependyma_morphology1.95317597
34MP0003786_premature_aging1.93413656
35MP0002396_abnormal_hematopoietic_system1.91188306
36MP0002210_abnormal_sex_determination1.90975686
37MP0005257_abnormal_intraocular_pressure1.88455335
38MP0005075_abnormal_melanosome_morpholog1.88164621
39MP0000350_abnormal_cell_proliferation1.85848332
40MP0003984_embryonic_growth_retardation1.79865445
41MP0002088_abnormal_embryonic_growth/wei1.77012155
42MP0001145_abnormal_male_reproductive1.72272058
43MP0000749_muscle_degeneration1.71090699
44MP0005394_taste/olfaction_phenotype1.70148015
45MP0005499_abnormal_olfactory_system1.70148015
46MP0002095_abnormal_skin_pigmentation1.69958927
47MP0004147_increased_porphyrin_level1.64624203
48MP0000678_abnormal_parathyroid_gland1.58210964
49MP0002938_white_spotting1.54794045
50MP0002168_other_aberrant_phenotype1.54372320
51MP0005410_abnormal_fertilization1.53184633
52MP0003718_maternal_effect1.50713012
53MP0000653_abnormal_sex_gland1.47243859
54MP0005365_abnormal_bile_salt1.46842200
55MP0002085_abnormal_embryonic_tissue1.46317386
56MP0003763_abnormal_thymus_physiology1.42910388
57MP0002086_abnormal_extraembryonic_tissu1.39208190
58MP0003698_abnormal_male_reproductive1.38739447
59MP0005395_other_phenotype1.36994926
60MP0008932_abnormal_embryonic_tissue1.35490706
61MP0003195_calcinosis1.33247977
62MP0001697_abnormal_embryo_size1.30811007
63MP0010307_abnormal_tumor_latency1.29343630
64MP0002084_abnormal_developmental_patter1.29125513
65MP0002019_abnormal_tumor_incidence1.27490743
66MP0002254_reproductive_system_inflammat1.25866845
67MP0000313_abnormal_cell_death1.22560478
68MP0003705_abnormal_hypodermis_morpholog1.21331511
69MP0002127_abnormal_cardiovascular_syste1.19058943
70MP0003122_maternal_imprinting1.19049537
71MP0002877_abnormal_melanocyte_morpholog1.19028237
72MP0002080_prenatal_lethality1.16458232
73MP0003787_abnormal_imprinting1.16271065
74MP0000427_abnormal_hair_cycle1.15643526
75MP0001293_anophthalmia1.13313630
76MP0000858_altered_metastatic_potential1.12393705
77MP0001119_abnormal_female_reproductive1.11657283
78MP0002277_abnormal_respiratory_mucosa1.08909069
79MP0004197_abnormal_fetal_growth/weight/1.08050476
80MP0002092_abnormal_eye_morphology1.07330939
81MP0003315_abnormal_perineum_morphology1.03108039
82MP0002075_abnormal_coat/hair_pigmentati1.02771953
83MP0004858_abnormal_nervous_system1.00505420
84MP0002876_abnormal_thyroid_physiology0.99778242
85MP0006035_abnormal_mitochondrial_morpho0.96819727
86MP0001661_extended_life_span0.95319138
87MP0003938_abnormal_ear_development0.94917456
88MP0002932_abnormal_joint_morphology0.94302779
89MP0005671_abnormal_response_to0.94296977
90MP0000428_abnormal_craniofacial_morphol0.94245026
91MP0002405_respiratory_system_inflammati0.92652048
92MP0002161_abnormal_fertility/fecundity0.92558980
93MP0002233_abnormal_nose_morphology0.91922469
94MP0005551_abnormal_eye_electrophysiolog0.91841729
95MP0003755_abnormal_palate_morphology0.91826592
96MP0001501_abnormal_sleep_pattern0.90200425
97MP0004233_abnormal_muscle_weight0.89633342
98MP0001849_ear_inflammation0.89174364
99MP0003937_abnormal_limbs/digits/tail_de0.89040722
100MP0003878_abnormal_ear_physiology0.86471350
101MP0005377_hearing/vestibular/ear_phenot0.86471350
102MP0002332_abnormal_exercise_endurance0.86134512
103MP0003137_abnormal_impulse_conducting0.85312187
104MP0000703_abnormal_thymus_morphology0.84856319
105MP0005174_abnormal_tail_pigmentation0.84267197
106MP0010030_abnormal_orbit_morphology0.84187562
107MP0005330_cardiomyopathy0.83938468
108MP0001984_abnormal_olfaction0.83186116
109MP0003183_abnormal_peptide_metabolism0.82815849
110MP0000490_abnormal_crypts_of0.82494786
111MP0000432_abnormal_head_morphology0.82062776
112MP0003699_abnormal_female_reproductive0.81683128
113MP0002735_abnormal_chemical_nociception0.81505775
114MP0003448_altered_tumor_morphology0.81398810
115MP0002269_muscular_atrophy0.81264426
116MP0000689_abnormal_spleen_morphology0.80691918
117MP0006072_abnormal_retinal_apoptosis0.78142516
118MP0003950_abnormal_plasma_membrane0.77879507
119MP0004381_abnormal_hair_follicle0.76539977
120MP0002722_abnormal_immune_system0.76350237
121MP0002970_abnormal_white_adipose0.75658562
122MP0003935_abnormal_craniofacial_develop0.75447382
123MP0000613_abnormal_salivary_gland0.74280622
124MP0002160_abnormal_reproductive_system0.74221794
125MP0002114_abnormal_axial_skeleton0.73044584
126MP0001486_abnormal_startle_reflex0.71205678
127MP0001324_abnormal_eye_pigmentation0.69756423
128MP0005384_cellular_phenotype0.68301935
129MP0009333_abnormal_splenocyte_physiolog0.68021114
130MP0005389_reproductive_system_phenotype0.67837864
131MP0005076_abnormal_cell_differentiation0.67760945
132MP0002398_abnormal_bone_marrow0.67167215
133MP0003252_abnormal_bile_duct0.66845776
134MP0001986_abnormal_taste_sensitivity0.66202622
135MP0001186_pigmentation_phenotype0.63310896
136MP0005621_abnormal_cell_physiology0.62978740
137MP0004043_abnormal_pH_regulation0.62846574
138MP0004808_abnormal_hematopoietic_stem0.62720932
139MP0005253_abnormal_eye_physiology0.62651069
140MP0005023_abnormal_wound_healing0.61275733
141MP0005266_abnormal_metabolism0.61194556
142MP0008004_abnormal_stomach_pH0.61139945
143MP0002272_abnormal_nervous_system0.60197538
144MP0000534_abnormal_ureter_morphology0.54153763
145MP0000372_irregular_coat_pigmentation0.54006017
146MP0009745_abnormal_behavioral_response0.53297949
147MP0000383_abnormal_hair_follicle0.52025755
148MP0006276_abnormal_autonomic_nervous0.50931308
149MP0005319_abnormal_enzyme/_coenzyme0.50380546
150MP0008770_decreased_survivor_rate0.50184959
151MP0002971_abnormal_brown_adipose0.49549499
152MP0000015_abnormal_ear_pigmentation0.48908671
153MP0002229_neurodegeneration0.47484109
154MP0001963_abnormal_hearing_physiology0.44320413
155MP0005360_urolithiasis0.43473196
156MP0005646_abnormal_pituitary_gland0.42859336
157MP0006054_spinal_hemorrhage0.41137775
158MP0001485_abnormal_pinna_reflex0.39598666
159MP0000026_abnormal_inner_ear0.38222672
160MP0002928_abnormal_bile_duct0.35349652
161MP0009115_abnormal_fat_cell0.34431068
162MP0001970_abnormal_pain_threshold0.32694581
163MP0005451_abnormal_body_composition0.30713296
164MP0008872_abnormal_physiological_respon0.29942698
165MP0001764_abnormal_homeostasis0.29680770
166MP0002572_abnormal_emotion/affect_behav0.29152702
167MP0005387_immune_system_phenotype0.28882243
168MP0001790_abnormal_immune_system0.28882243
169MP0009046_muscle_twitch0.28623526
170MP0003959_abnormal_lean_body0.27211803
171MP0008569_lethality_at_weaning0.25908781
172MP0000681_abnormal_thyroid_gland0.25497419

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)8.59260085
2Focal motor seizures (HP:0011153)7.61531943
3Acanthocytosis (HP:0001927)6.36967439
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.17622803
5Parakeratosis (HP:0001036)5.09016349
6Abnormality of the lower motor neuron (HP:0002366)4.80167432
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.61736972
8Aplastic anemia (HP:0001915)4.46938325
9Congenital stationary night blindness (HP:0007642)4.44913088
10Chromsome breakage (HP:0040012)4.41359834
11Bilateral microphthalmos (HP:0007633)4.37082780
12Multiple enchondromatosis (HP:0005701)4.26887183
13Hypochromic microcytic anemia (HP:0004840)4.16271969
14Rib fusion (HP:0000902)4.08909803
15Impulsivity (HP:0100710)3.97835138
16Pancreatic cysts (HP:0001737)3.80055308
17Ependymoma (HP:0002888)3.73836973
18Rectal prolapse (HP:0002035)3.72707752
19Nasal polyposis (HP:0100582)3.64257732
20Dialeptic seizures (HP:0011146)3.56300059
21Congenital ichthyosiform erythroderma (HP:0007431)3.53599020
22Severe visual impairment (HP:0001141)3.48258956
23Proximal amyotrophy (HP:0007126)3.43596171
24Hypoplasia of the fovea (HP:0007750)3.43356024
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.43356024
26Meckel diverticulum (HP:0002245)3.42505332
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.39432532
28Combined immunodeficiency (HP:0005387)3.37613819
29Colon cancer (HP:0003003)3.36635378
30Aplasia/Hypoplasia of the uvula (HP:0010293)3.35768796
31Abnormality of the renal medulla (HP:0100957)3.27860569
32Nephroblastoma (Wilms tumor) (HP:0002667)3.25307610
33Amyotrophic lateral sclerosis (HP:0007354)3.24531788
34Abnormality of the renal cortex (HP:0011035)3.20067739
35Rhabdomyosarcoma (HP:0002859)3.19818106
36Tubulointerstitial nephritis (HP:0001970)3.16791251
37Abnormality of the ileum (HP:0001549)3.13451556
38Difficulty walking (HP:0002355)3.13361262
39Abnormality of the phalanges of the hallux (HP:0010057)3.13114748
40Abnormal lung lobation (HP:0002101)3.10658603
41Vertebral arch anomaly (HP:0008438)3.10444235
42Hepatoblastoma (HP:0002884)3.06944890
43Erythroderma (HP:0001019)3.05575363
44Supernumerary spleens (HP:0009799)3.05048823
45Birth length less than 3rd percentile (HP:0003561)3.02423665
46Nephronophthisis (HP:0000090)3.01561975
47Progressive muscle weakness (HP:0003323)3.00086148
48Hypoplastic iliac wings (HP:0002866)2.99155573
49Facial shape deformation (HP:0011334)2.98275734
50Potter facies (HP:0002009)2.98275734
51Spontaneous hematomas (HP:0007420)2.98262054
52Hematochezia (HP:0002573)2.96930060
53Embryonal renal neoplasm (HP:0011794)2.95468144
54Volvulus (HP:0002580)2.94637104
55Neoplasm of striated muscle (HP:0009728)2.94407678
56Focal seizures (HP:0007359)2.90886368
57T lymphocytopenia (HP:0005403)2.89407158
58Scapular winging (HP:0003691)2.87261751
59Rectal fistula (HP:0100590)2.85526560
60Rectovaginal fistula (HP:0000143)2.85526560
61Abnormality of chromosome stability (HP:0003220)2.84650321
62Breast hypoplasia (HP:0003187)2.84525699
63Tubular atrophy (HP:0000092)2.81887668
64Poikilocytosis (HP:0004447)2.80943168
65Chronic hepatic failure (HP:0100626)2.77306277
66Abnormality of the nasal mucosa (HP:0000433)2.77257897
67Abnormality of the preputium (HP:0100587)2.76071823
68Microretrognathia (HP:0000308)2.73351811
69Shawl scrotum (HP:0000049)2.73249054
70Upper motor neuron abnormality (HP:0002127)2.72367517
71Gonadotropin excess (HP:0000837)2.70341541
72Aplasia/hypoplasia of the humerus (HP:0006507)2.68781992
73Tetraplegia (HP:0002445)2.68577619
74Small intestinal stenosis (HP:0012848)2.68498921
75Duodenal stenosis (HP:0100867)2.68498921
76Bifid tongue (HP:0010297)2.66502798
77Abnormality of T cell number (HP:0011839)2.65024721
78Type II lissencephaly (HP:0007260)2.63155827
79Esophageal varix (HP:0002040)2.63012785
80Portal hypertension (HP:0001409)2.62208683
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.58887746
82Tubulointerstitial abnormality (HP:0001969)2.56660047
83Cerebellar dysplasia (HP:0007033)2.54091228
84Intestinal fistula (HP:0100819)2.50997950
85Ulnar claw (HP:0001178)2.50231870
86Premature ovarian failure (HP:0008209)2.50051405
87Abnormality of the fovea (HP:0000493)2.49829528
88Abnormality of the astrocytes (HP:0100707)2.49546492
89Astrocytoma (HP:0009592)2.49546492
90Bilateral sensorineural hearing impairment (HP:0008619)2.48674085
91Carpal bone hypoplasia (HP:0001498)2.46239347
92Vaginal fistula (HP:0004320)2.45420499
93Short humerus (HP:0005792)2.44865918
94Hyperinsulinemic hypoglycemia (HP:0000825)2.43695099
95Aplasia/Hypoplasia of the macula (HP:0008059)2.40950339
96Conjunctival telangiectasia (HP:0000524)2.40554372
97Patellar aplasia (HP:0006443)2.38550447
98Abnormality of the hepatic vasculature (HP:0006707)2.38242217
99Secondary amenorrhea (HP:0000869)2.37509362
100Abnormality of macular pigmentation (HP:0008002)2.37062040
101Horizontal nystagmus (HP:0000666)2.35427710
102Synostosis of carpal bones (HP:0005048)2.34487958
103Abnormality of the shoulder girdle musculature (HP:0001435)2.33018095
104Facial hemangioma (HP:0000329)2.32730756
105Abnormal spermatogenesis (HP:0008669)2.32393229
106Fused cervical vertebrae (HP:0002949)2.32041545
107Abnormality of the vocal cords (HP:0008777)2.29593625
108Dehydration (HP:0001944)2.29272203
109Sloping forehead (HP:0000340)2.27195931
110Hyperkalemia (HP:0002153)2.26439632
111Progressive external ophthalmoplegia (HP:0000590)2.25682381
112Atrophy/Degeneration involving motor neurons (HP:0007373)2.23033474
113Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22949124
114Abnormality of chromosome segregation (HP:0002916)2.22510978
115Abnormality of the salivary glands (HP:0010286)2.19073975
116Abnormality of the labia minora (HP:0012880)2.18732732
117Abnormality of potassium homeostasis (HP:0011042)2.18542706
118Cystic liver disease (HP:0006706)2.17725696
119Hypoalbuminemia (HP:0003073)2.17655568
120Abnormal albumin level (HP:0012116)2.17655568
121Retinitis pigmentosa (HP:0000510)2.17505569
122Aplasia/Hypoplasia of the sternum (HP:0006714)2.15596824
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15388864
124Aplasia/Hypoplasia of the patella (HP:0006498)2.15218601
125Spontaneous abortion (HP:0005268)2.15011415
126Oligodactyly (hands) (HP:0001180)2.13240725
127Enlarged kidneys (HP:0000105)2.12598045
128Stage 5 chronic kidney disease (HP:0003774)2.12339229
129Abnormality of the duodenum (HP:0002246)2.12305421
130Testicular atrophy (HP:0000029)2.11831231
131Scotoma (HP:0000575)2.11817929
132Glioma (HP:0009733)2.11723007
133Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11549836
134Abnormal cartilage morphology (HP:0002763)2.11107771
135Azoospermia (HP:0000027)2.11096885
136Radial bowing (HP:0002986)2.10802096
137Overlapping toe (HP:0001845)2.10261672
138Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09591726
139Missing ribs (HP:0000921)2.07789351
140Facial cleft (HP:0002006)2.07216757
141Type I transferrin isoform profile (HP:0003642)2.05868630
142Hypopigmentation of the fundus (HP:0007894)2.04700753
143Myelodysplasia (HP:0002863)2.03864839
144Tongue fasciculations (HP:0001308)2.03641820
145Hypokalemia (HP:0002900)2.03570325
146Atresia of the external auditory canal (HP:0000413)2.03110328
147Non-midline cleft lip (HP:0100335)2.02455327
148Proximal tubulopathy (HP:0000114)2.01858042
149Pendular nystagmus (HP:0012043)2.01421803
150Preauricular pit (HP:0004467)1.99417030
151Periauricular skin pits (HP:0100277)1.99417030
152Tubulointerstitial fibrosis (HP:0005576)1.99131354
153Progressive inability to walk (HP:0002505)1.98725683
154Trismus (HP:0000211)1.98412884
155Medulloblastoma (HP:0002885)1.96553426
156Reduced antithrombin III activity (HP:0001976)1.94282600
157Hand muscle atrophy (HP:0009130)1.93856986
158Hypochromic anemia (HP:0001931)1.93665030
159Subcapsular cataract (HP:0000523)1.92773731
160Neoplasm of the colon (HP:0100273)1.92572814
161Abnormal ciliary motility (HP:0012262)1.92477228
162Prominent nose (HP:0000448)1.89044403
163Muscle fibrillation (HP:0010546)1.87456095
164Flat capital femoral epiphysis (HP:0003370)1.86920308
165Congenital hepatic fibrosis (HP:0002612)1.86528841
166Papillary thyroid carcinoma (HP:0002895)1.86430479
167Glossoptosis (HP:0000162)1.85964703
168Clubbing of toes (HP:0100760)1.84821898
169Chronic diarrhea (HP:0002028)1.84030122
170Skin pits (HP:0100276)1.82633429
171Lip pit (HP:0100267)1.82263735
172Chronic bronchitis (HP:0004469)1.81210980
173Abnormality of the wing of the ilium (HP:0011867)1.81169035
174Bony spicule pigmentary retinopathy (HP:0007737)1.80192668
175Degeneration of the lateral corticospinal tracts (HP:0002314)1.79771762
176Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79771762
177Neoplasm of the small intestine (HP:0100833)1.79381237
178Abnormal biliary tract physiology (HP:0012439)1.79201798
179Bile duct proliferation (HP:0001408)1.79201798
180Ulnar bowing (HP:0003031)1.78618783
181Decreased circulating renin level (HP:0003351)1.78454302
182Bone marrow hypocellularity (HP:0005528)1.78129753
183Gastrointestinal stroma tumor (HP:0100723)1.76800531
184Chronic sinusitis (HP:0011109)1.74743521
185Dynein arm defect of respiratory motile cilia (HP:0012255)1.73911050
186Absent/shortened dynein arms (HP:0200106)1.73911050
187Recurrent sinusitis (HP:0011108)1.73604605
188IgM deficiency (HP:0002850)1.67769198
189Albinism (HP:0001022)1.65748286
190Abnormality of the renal collecting system (HP:0004742)1.64757716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.19997092
2GRK53.78717841
3CDC73.47300058
4TTK3.29412341
5GRK63.29007973
6ACVR1B2.70179288
7WEE12.66729633
8GRK12.53562472
9NEK22.45652175
10ERN12.37412457
11ADRBK22.33049610
12FRK2.22730557
13BRSK22.20157430
14PLK12.11148097
15NLK2.04890362
16CDK71.99095054
17MAP2K21.97702601
18STK101.86018359
19CHEK21.85909394
20STK38L1.83117081
21CSF1R1.78938726
22BMPR1B1.74434013
23TYRO31.65183220
24BUB11.62046933
25MAPK71.58948867
26SRPK11.52698806
27LATS21.50697129
28PLK41.39608822
29CHEK11.32009495
30MELK1.31124816
31WNK11.30143071
32AURKB1.26994507
33CSK1.24532533
34PIK3CG1.22793309
35MOS1.22379967
36ITK1.20818748
37PDPK11.19730232
38TGFBR21.15982222
39BRSK11.14201747
40STK31.09828573
41CDK41.06600530
42GRK71.05276910
43CDK191.03013844
44PNCK1.02959752
45PDK41.02114284
46PDK31.02114284
47BRD41.01213844
48EPHA21.01210285
49KSR21.00939156
50MATK1.00120797
51LATS10.97754065
52MAP3K130.97691731
53FGFR30.94840315
54PDK20.93490422
55DYRK30.93165963
56PASK0.93003872
57ATR0.91877197
58ATM0.91803702
59ALK0.87941138
60AURKA0.86284987
61PRKAA20.83076559
62MAP3K20.81060806
63PINK10.81055527
64MAP2K60.80717942
65CDK80.80165314
66TAF10.80046854
67MAP3K100.79987460
68CDK20.79788001
69PLK30.74186162
70HIPK20.72228156
71CAMK40.70241039
72AKT30.69692042
73OXSR10.68725946
74EIF2AK20.67525857
75EIF2AK10.66953004
76MARK20.66176070
77IRAK30.63266101
78PRKCI0.60964114
79MTOR0.60471166
80MAP3K90.60360992
81PRKD10.60191670
82TGFBR10.59517462
83CDK10.58870150
84PAK40.58861527
85PLK20.56336120
86STK380.52441536
87EIF2AK30.52012818
88NEK90.50721367
89PRKG20.49174927
90STK240.48753120
91ZAK0.48370795
92CDK90.46459437
93TESK20.46374280
94ADRBK10.42738882
95VRK10.41557732
96WNK40.40365205
97PRKAA10.39940991
98STK110.39631839
99RPS6KB20.39289272
100CDK30.39201509
101MAP3K80.39105408
102STK40.38859232
103DYRK20.38079250
104CSNK1A1L0.36888554
105ERBB40.35454118
106NEK60.34913111
107MAP2K10.34340216
108AKT20.33955978
109MAP2K40.33628715
110INSRR0.32234818
111CSNK1E0.31250744
112PTK2B0.30127266
113MAPK100.29523402
114PDK10.27798616
115ARAF0.27651148
116IGF1R0.27399833
117TNK20.26435596
118MAPKAPK30.24838518
119STK390.24643122
120DYRK1A0.23868925
121MAPK140.23700300
122GSK3B0.23679325
123NEK10.22856275
124NTRK10.22566854
125PAK10.22207119
126PIM10.21699502
127CSNK2A10.21530968
128MET0.20716340
129MAP3K50.19511663
130CHUK0.19318564
131PRKD30.19263717
132MARK30.19083967
133DAPK20.18917121
134CDK60.18745578
135BRAF0.18214611
136NME10.17061000
137CAMK1G0.16510720
138TAOK30.13143811
139MAP3K70.12926763
140MAP3K10.12886788
141SIK20.10907258
142CSNK1D0.09526479
143PRKACB0.08774093
144TLK10.08090428
145MAPK30.07923841
146FER0.07858199
147PRKACA0.07335465
148MAPK10.07244217
149CCNB10.05280584
150CAMK2A0.05120086
151PRKCE0.03976111
152TIE10.03515425
153KIT0.03269135
154RET0.02764071
155CAMK2B0.00564363
156ABL10.00058129

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004007.35036769
2Vitamin B6 metabolism_Homo sapiens_hsa007505.81697129
3Phototransduction_Homo sapiens_hsa047445.74686059
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.96875731
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.32381121
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.19585095
7Sphingolipid metabolism_Homo sapiens_hsa006003.07783817
8Homologous recombination_Homo sapiens_hsa034403.02219909
9Cell cycle_Homo sapiens_hsa041102.98393441
10DNA replication_Homo sapiens_hsa030302.94451544
11RNA polymerase_Homo sapiens_hsa030202.94303972
12RNA transport_Homo sapiens_hsa030132.89869369
13Phenylalanine metabolism_Homo sapiens_hsa003602.78507165
14Fanconi anemia pathway_Homo sapiens_hsa034602.78503069
15Mismatch repair_Homo sapiens_hsa034302.71920732
16Basal transcription factors_Homo sapiens_hsa030222.64917677
17Nicotine addiction_Homo sapiens_hsa050332.62873757
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62271149
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17995435
20Taste transduction_Homo sapiens_hsa047422.10990407
21RNA degradation_Homo sapiens_hsa030182.04771287
22p53 signaling pathway_Homo sapiens_hsa041151.99264016
23mRNA surveillance pathway_Homo sapiens_hsa030151.87733143
24Linoleic acid metabolism_Homo sapiens_hsa005911.70980541
25Primary immunodeficiency_Homo sapiens_hsa053401.67438771
26Nucleotide excision repair_Homo sapiens_hsa034201.66060068
27Morphine addiction_Homo sapiens_hsa050321.65188898
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64239405
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63213587
30N-Glycan biosynthesis_Homo sapiens_hsa005101.61182954
31Spliceosome_Homo sapiens_hsa030401.61100536
32Pyrimidine metabolism_Homo sapiens_hsa002401.55454651
33Tryptophan metabolism_Homo sapiens_hsa003801.52250321
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46850985
35Fructose and mannose metabolism_Homo sapiens_hsa000511.41121230
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39084986
37Arachidonic acid metabolism_Homo sapiens_hsa005901.36448015
38Non-homologous end-joining_Homo sapiens_hsa034501.35620698
39Base excision repair_Homo sapiens_hsa034101.33407709
40Histidine metabolism_Homo sapiens_hsa003401.32261287
41Calcium signaling pathway_Homo sapiens_hsa040201.28165780
42ABC transporters_Homo sapiens_hsa020101.24927643
43Selenocompound metabolism_Homo sapiens_hsa004501.20201572
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20133836
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19563541
46One carbon pool by folate_Homo sapiens_hsa006701.17619383
47Pentose phosphate pathway_Homo sapiens_hsa000301.14106446
48GABAergic synapse_Homo sapiens_hsa047271.13145384
49Olfactory transduction_Homo sapiens_hsa047401.12863496
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12648567
51Tyrosine metabolism_Homo sapiens_hsa003501.11166258
52Fatty acid biosynthesis_Homo sapiens_hsa000611.09786538
53Herpes simplex infection_Homo sapiens_hsa051681.08339952
54Galactose metabolism_Homo sapiens_hsa000521.05950905
55mTOR signaling pathway_Homo sapiens_hsa041500.99897273
56Antigen processing and presentation_Homo sapiens_hsa046120.99004973
57Nitrogen metabolism_Homo sapiens_hsa009100.98850848
58Oocyte meiosis_Homo sapiens_hsa041140.98116303
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97121166
60Other glycan degradation_Homo sapiens_hsa005110.96774181
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96365357
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95477385
63Thyroid cancer_Homo sapiens_hsa052160.94460038
64Serotonergic synapse_Homo sapiens_hsa047260.89526076
65Purine metabolism_Homo sapiens_hsa002300.88666692
66Folate biosynthesis_Homo sapiens_hsa007900.88479068
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86942216
68beta-Alanine metabolism_Homo sapiens_hsa004100.83256096
69Lysine degradation_Homo sapiens_hsa003100.81020186
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.80542133
71Propanoate metabolism_Homo sapiens_hsa006400.79006978
72Glutamatergic synapse_Homo sapiens_hsa047240.78442189
73Dilated cardiomyopathy_Homo sapiens_hsa054140.77937685
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77409519
75Ovarian steroidogenesis_Homo sapiens_hsa049130.74913682
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74130412
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72633468
78Viral myocarditis_Homo sapiens_hsa054160.70204286
79Pyruvate metabolism_Homo sapiens_hsa006200.67896849
80Regulation of autophagy_Homo sapiens_hsa041400.67781012
81MicroRNAs in cancer_Homo sapiens_hsa052060.66566069
82ECM-receptor interaction_Homo sapiens_hsa045120.65808290
83Ether lipid metabolism_Homo sapiens_hsa005650.65536405
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65260716
85Epstein-Barr virus infection_Homo sapiens_hsa051690.62816311
86Glycerolipid metabolism_Homo sapiens_hsa005610.61256506
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.61152754
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60858579
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.59634410
90Viral carcinogenesis_Homo sapiens_hsa052030.59391937
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.59302389
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59242244
93HTLV-I infection_Homo sapiens_hsa051660.59029733
94Retinol metabolism_Homo sapiens_hsa008300.58659510
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58508144
96cAMP signaling pathway_Homo sapiens_hsa040240.57969283
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57764104
98T cell receptor signaling pathway_Homo sapiens_hsa046600.56744585
99Bile secretion_Homo sapiens_hsa049760.56205722
100Butanoate metabolism_Homo sapiens_hsa006500.56147443
101Fatty acid degradation_Homo sapiens_hsa000710.55178505
102Inositol phosphate metabolism_Homo sapiens_hsa005620.54311277
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53826980
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.52880903
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51598991
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49977832
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.47944903
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47890186
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.47210379
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.46465584
111Biosynthesis of amino acids_Homo sapiens_hsa012300.46241641
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45568094
113Vitamin digestion and absorption_Homo sapiens_hsa049770.45510880
114Pancreatic cancer_Homo sapiens_hsa052120.44479433
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43459285
116Small cell lung cancer_Homo sapiens_hsa052220.42364424
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42293777
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.41021540
119Sulfur relay system_Homo sapiens_hsa041220.40615257
120Salivary secretion_Homo sapiens_hsa049700.40223165
121Choline metabolism in cancer_Homo sapiens_hsa052310.37816135
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36779148
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36724814
124Proteasome_Homo sapiens_hsa030500.36561430
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35487831
126Non-small cell lung cancer_Homo sapiens_hsa052230.34315452
127Circadian rhythm_Homo sapiens_hsa047100.33128466
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32787392
129Colorectal cancer_Homo sapiens_hsa052100.32265846
130Dorso-ventral axis formation_Homo sapiens_hsa043200.31134580
131Apoptosis_Homo sapiens_hsa042100.30356622
132Pathways in cancer_Homo sapiens_hsa052000.29284883
133Circadian entrainment_Homo sapiens_hsa047130.29009209
134TGF-beta signaling pathway_Homo sapiens_hsa043500.28824009
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28600708
136Adherens junction_Homo sapiens_hsa045200.28093083
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.27548462
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27323997
139Collecting duct acid secretion_Homo sapiens_hsa049660.26896518
140B cell receptor signaling pathway_Homo sapiens_hsa046620.26050765
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25970877
142VEGF signaling pathway_Homo sapiens_hsa043700.25824961
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25798176
144FoxO signaling pathway_Homo sapiens_hsa040680.25278561
145Chemical carcinogenesis_Homo sapiens_hsa052040.23917891
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.23828223
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23772697
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.23624467
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23310435
150Caffeine metabolism_Homo sapiens_hsa002320.22283337
151Influenza A_Homo sapiens_hsa051640.22005277
152Measles_Homo sapiens_hsa051620.21529678
153Hippo signaling pathway_Homo sapiens_hsa043900.20692546
154Arginine and proline metabolism_Homo sapiens_hsa003300.20675449
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19719945
156Asthma_Homo sapiens_hsa053100.19667601
157African trypanosomiasis_Homo sapiens_hsa051430.19416966
158Metabolic pathways_Homo sapiens_hsa011000.19237142
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18801225
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17767488
161Hedgehog signaling pathway_Homo sapiens_hsa043400.17410535
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17172155
163Acute myeloid leukemia_Homo sapiens_hsa052210.17052064
164Oxytocin signaling pathway_Homo sapiens_hsa049210.16918197
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15971192
166Hematopoietic cell lineage_Homo sapiens_hsa046400.14262755
167Adipocytokine signaling pathway_Homo sapiens_hsa049200.13481277
168Type II diabetes mellitus_Homo sapiens_hsa049300.12350818

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