FBXO46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of nuclear cell cycle DNA replication (GO:0033262)3.81837764
2negative regulation of B cell apoptotic process (GO:0002903)3.81536167
3DNA strand elongation involved in DNA replication (GO:0006271)3.78558840
4heterochromatin organization (GO:0070828)3.72733028
5doxorubicin metabolic process (GO:0044598)3.60528760
6daunorubicin metabolic process (GO:0044597)3.60528760
7polyketide metabolic process (GO:0030638)3.60528760
8tRNA methylation (GO:0030488)3.59603786
9DNA strand elongation (GO:0022616)3.57232618
10mitotic sister chromatid segregation (GO:0000070)3.44899538
11regulation of chromatin binding (GO:0035561)3.42601586
12regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42414718
13ribosomal small subunit biogenesis (GO:0042274)3.39897195
14DNA replication checkpoint (GO:0000076)3.34247088
15sequestering of actin monomers (GO:0042989)3.34196500
16signal peptide processing (GO:0006465)3.33678839
17telomere maintenance via semi-conservative replication (GO:0032201)3.32295402
18negative regulation of mRNA metabolic process (GO:1903312)3.27098678
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23430025
20positive regulation of gene expression, epigenetic (GO:0045815)3.23298720
21positive regulation of histone deacetylation (GO:0031065)3.21753218
22regulation of B cell apoptotic process (GO:0002902)3.19273385
23presynaptic membrane organization (GO:0097090)3.17207480
24negative regulation of mRNA processing (GO:0050686)3.14990596
25CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13939954
26transcription from mitochondrial promoter (GO:0006390)3.11977985
27sister chromatid segregation (GO:0000819)3.07749459
28regulation of B cell receptor signaling pathway (GO:0050855)3.06664578
29cell differentiation involved in metanephros development (GO:0072202)3.04540339
30chromatin assembly (GO:0031497)3.03791362
31DNA replication initiation (GO:0006270)3.02109868
32positive regulation of antigen processing and presentation (GO:0002579)3.01238734
33superoxide anion generation (GO:0042554)3.00409310
34dendritic cell chemotaxis (GO:0002407)2.98961895
35thymic T cell selection (GO:0045061)2.98591438
36metallo-sulfur cluster assembly (GO:0031163)2.97851247
37iron-sulfur cluster assembly (GO:0016226)2.97851247
38DNA unwinding involved in DNA replication (GO:0006268)2.97318182
39histone H4-K16 acetylation (GO:0043984)2.96225565
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96158089
41positive regulation of protein sumoylation (GO:0033235)2.96076156
42T cell lineage commitment (GO:0002360)2.95535684
43viral transcription (GO:0019083)2.94287788
44mitotic nuclear envelope disassembly (GO:0007077)2.93953901
45presynaptic membrane assembly (GO:0097105)2.92603263
46kinetochore assembly (GO:0051382)2.91345726
47kinetochore organization (GO:0051383)2.89534103
48histone H4-K8 acetylation (GO:0043982)2.88102357
49histone H4-K5 acetylation (GO:0043981)2.88102357
50positive thymic T cell selection (GO:0045059)2.87042841
51protein K6-linked ubiquitination (GO:0085020)2.86569636
52mitotic chromosome condensation (GO:0007076)2.84228002
53DNA catabolic process, exonucleolytic (GO:0000738)2.83426780
54respiratory chain complex IV assembly (GO:0008535)2.83391591
55telomere maintenance via recombination (GO:0000722)2.82765540
56ribosomal small subunit assembly (GO:0000028)2.82221905
57histone H3-K4 trimethylation (GO:0080182)2.81502422
58maturation of 5.8S rRNA (GO:0000460)2.76787651
59maturation of SSU-rRNA (GO:0030490)2.76737009
60translational termination (GO:0006415)2.76666049
61cytochrome complex assembly (GO:0017004)2.76442773
62mitotic recombination (GO:0006312)2.75400482
63regulation of histone H3-K27 methylation (GO:0061085)2.74360360
64myeloid dendritic cell activation (GO:0001773)2.74225225
65regulation of antigen processing and presentation (GO:0002577)2.73782568
66centriole assembly (GO:0098534)2.73628897
67negative regulation of phagocytosis (GO:0050765)2.72137970
68microtubule depolymerization (GO:0007019)2.70683287
69DNA replication-dependent nucleosome assembly (GO:0006335)2.69102928
70DNA replication-dependent nucleosome organization (GO:0034723)2.69102928
71nuclear envelope disassembly (GO:0051081)2.69093633
72membrane disassembly (GO:0030397)2.69093633
73regulation of translation, ncRNA-mediated (GO:0045974)2.68965058
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68965058
75negative regulation of translation, ncRNA-mediated (GO:0040033)2.68965058
76negative T cell selection (GO:0043383)2.68447277
77interferon-gamma production (GO:0032609)2.68429318
78positive regulation of protein deacetylation (GO:0090312)2.67868380
79pseudouridine synthesis (GO:0001522)2.66858821
80negative regulation of telomerase activity (GO:0051974)2.64432801
81mitotic sister chromatid cohesion (GO:0007064)2.64318346
82poly(A)+ mRNA export from nucleus (GO:0016973)2.64015927
83NIK/NF-kappaB signaling (GO:0038061)2.62809489
84negative regulation of mast cell activation (GO:0033004)2.62424513
85regulation of histone H3-K4 methylation (GO:0051569)2.61869930
86ribosome biogenesis (GO:0042254)2.60927688
87hepatocyte apoptotic process (GO:0097284)2.59499887
88histone H4 acetylation (GO:0043967)2.58769072
89negative regulation of RNA splicing (GO:0033119)2.58395102
90pre-miRNA processing (GO:0031054)2.57825956
91negative thymic T cell selection (GO:0045060)2.57674754
92regulation of male gonad development (GO:2000018)2.57634450
93negative regulation of viral genome replication (GO:0045071)2.56966336
94DNA strand renaturation (GO:0000733)2.56928652
95translational elongation (GO:0006414)2.56357280
96modulation by virus of host process (GO:0019054)2.56179188
97formation of translation preinitiation complex (GO:0001731)2.55839575
98folic acid metabolic process (GO:0046655)2.53544890
99protein-DNA complex disassembly (GO:0032986)2.52861225
100nucleosome disassembly (GO:0006337)2.52861225
101termination of RNA polymerase II transcription (GO:0006369)2.50138595
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49703014
103regulation of mitotic spindle checkpoint (GO:1903504)2.49703014
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49402738
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.49402738
106base-excision repair (GO:0006284)2.48903129
107cellular response to interferon-beta (GO:0035458)2.48262154
108positive regulation of DNA recombination (GO:0045911)2.47160343
109regulation of RIG-I signaling pathway (GO:0039535)2.46983499
110pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.46901315
111chromatin assembly or disassembly (GO:0006333)2.45979281
112snRNA processing (GO:0016180)2.45454483
113ribonucleoprotein complex biogenesis (GO:0022613)2.45003521
114meiotic chromosome segregation (GO:0045132)2.44856494
115rRNA methylation (GO:0031167)2.44229472
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43845444
117intra-S DNA damage checkpoint (GO:0031573)2.43773776
118DNA methylation involved in gamete generation (GO:0043046)2.43172513
119protein prenylation (GO:0018342)2.42534304
120prenylation (GO:0097354)2.42534304
121regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.42224774
122termination of RNA polymerase III transcription (GO:0006386)2.42107373
123transcription elongation from RNA polymerase III promoter (GO:0006385)2.42107373
124dendritic cell migration (GO:0036336)2.42102922
125negative regulation of viral release from host cell (GO:1902187)2.42018026
126rRNA processing (GO:0006364)2.41296112
127negative regulation of histone acetylation (GO:0035067)2.40849083
128intracellular estrogen receptor signaling pathway (GO:0030520)2.39876795
129histone H3-K4 methylation (GO:0051568)2.39774930
130histone H2A acetylation (GO:0043968)2.39702332
131cellular response to gamma radiation (GO:0071480)2.39526331
132protein localization to kinetochore (GO:0034501)2.39333245
133negative regulation of peptidyl-lysine acetylation (GO:2000757)2.39185016
134regulation of double-strand break repair via homologous recombination (GO:0010569)2.39064478
135regulation of RNA export from nucleus (GO:0046831)2.37847813
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.37155012
137natural killer cell activation involved in immune response (GO:0002323)2.36604275
138chromatin silencing (GO:0006342)2.35666698
139negative regulation of execution phase of apoptosis (GO:1900118)2.35247594
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.34961096
141rRNA metabolic process (GO:0016072)2.32979933
142negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.32552483
143positive regulation of gamma-delta T cell activation (GO:0046645)2.32286592
144telomere maintenance via telomere lengthening (GO:0010833)2.32064911
145sulfate transmembrane transport (GO:1902358)2.31970863
146T cell selection (GO:0045058)2.31865049
147cellular response to exogenous dsRNA (GO:0071360)2.31266246
148positive regulation of cell cycle G2/M phase transition (GO:1902751)2.30745755
149positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.30745755
150mannosylation (GO:0097502)2.29972570
151DNA duplex unwinding (GO:0032508)2.29412696
152translational initiation (GO:0006413)2.29091674
153megakaryocyte development (GO:0035855)2.28780117
154positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.28636402
155negative regulation of histone methylation (GO:0031061)2.27323122
156tRNA modification (GO:0006400)2.27111681
157neutrophil activation (GO:0042119)2.27092492
158proteasome assembly (GO:0043248)2.25586286
159negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.24434862
160postsynaptic membrane organization (GO:0001941)2.24169732
161RNA methylation (GO:0001510)2.23492306
162myeloid dendritic cell differentiation (GO:0043011)2.22983442
163centriole replication (GO:0007099)2.22291727
164negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.22104925
165negative regulation of T-helper cell differentiation (GO:0045623)2.22104925
166rRNA modification (GO:0000154)2.22094337
167positive regulation of T cell migration (GO:2000406)2.21638133
168negative regulation of telomere maintenance (GO:0032205)2.21330188
169DNA ligation (GO:0006266)2.19472700
170sympathetic nervous system development (GO:0048485)2.18477085
171G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.17837293
172sulfate transport (GO:0008272)2.16402471
173positive regulation of keratinocyte differentiation (GO:0045618)2.16148907
174positive T cell selection (GO:0043368)2.16131190
175RNA-dependent DNA replication (GO:0006278)2.13970488
176cellular response to interleukin-15 (GO:0071350)2.13912706
177regulation of B cell differentiation (GO:0045577)2.13738200
178neural tube formation (GO:0001841)2.13421402
179positive regulation of male gonad development (GO:2000020)2.13380256
180deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.13338683
181mesenchymal cell differentiation involved in renal system development (GO:2001012)2.12978776
182mesenchymal cell differentiation involved in kidney development (GO:0072161)2.12978776
183negative regulation of signal transduction by p53 class mediator (GO:1901797)2.12163374
184snRNA metabolic process (GO:0016073)2.11970403
185transcription from RNA polymerase I promoter (GO:0006360)2.10873475
186protein K11-linked ubiquitination (GO:0070979)2.10787714
187viral protein processing (GO:0019082)2.10263255
188DNA deamination (GO:0045006)2.10066068
189glycosphingolipid catabolic process (GO:0046479)2.09849272
190response to interferon-beta (GO:0035456)2.09830362
191positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.09788850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.09200829
2MYC_22102868_ChIP-Seq_BL_Human3.80798044
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.51381826
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49356227
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.32364165
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90600008
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90341965
8VDR_21846776_ChIP-Seq_THP-1_Human2.83057704
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79421030
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76640996
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.65767274
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.56772885
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.52007047
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.46958244
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44896415
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40335199
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28014374
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.20916140
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18544478
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18194696
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15682257
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.11380737
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10771360
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10091549
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08885148
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.08870797
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08720988
28XRN2_22483619_ChIP-Seq_HELA_Human2.08635568
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06452329
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05634640
31CIITA_25753668_ChIP-Seq_RAJI_Human2.04598344
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.01397239
33* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00363868
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95842702
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.93071191
36ELK1_19687146_ChIP-ChIP_HELA_Human1.90197835
37KDM5A_27292631_Chip-Seq_BREAST_Human1.88455299
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82814531
39FOXP3_21729870_ChIP-Seq_TREG_Human1.77464753
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76603035
41MAF_26560356_Chip-Seq_TH1_Human1.75410635
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73776027
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.73428793
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72843345
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71971491
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70676539
47* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68945192
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68179480
49VDR_23849224_ChIP-Seq_CD4+_Human1.68088485
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67944604
51MAF_26560356_Chip-Seq_TH2_Human1.67301391
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65321710
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.62980693
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62827097
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.62494700
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.61768245
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60331906
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59471887
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.59360272
60SPI1_23547873_ChIP-Seq_NB4_Human1.57374393
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57179821
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55211328
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54249636
64UTX_26944678_Chip-Seq_JUKART_Human1.53855618
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52929914
66IRF1_19129219_ChIP-ChIP_H3396_Human1.52534548
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51716996
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51027553
69TTF2_22483619_ChIP-Seq_HELA_Human1.50309140
70KDM2B_26808549_Chip-Seq_DND41_Human1.50262304
71* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47213614
72GABP_19822575_ChIP-Seq_HepG2_Human1.46881828
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44216273
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42711455
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42288494
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41609180
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40541614
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39432105
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38522829
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34686562
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.34002309
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33268869
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31584096
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29447317
85MYB_26560356_Chip-Seq_TH2_Human1.28191835
86RACK7_27058665_Chip-Seq_MCF-7_Human1.28168102
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27347325
88* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26932784
89MYC_18940864_ChIP-ChIP_HL60_Human1.26894796
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.26091292
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25772851
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.25540706
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25189668
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24943347
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24826116
96VDR_24763502_ChIP-Seq_THP-1_Human1.23486270
97LXR_22292898_ChIP-Seq_THP-1_Human1.23052238
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.22625551
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22485800
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.22161549
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22123573
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20721935
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18897787
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18414785
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.18013716
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17862637
107NCOR1_26117541_ChIP-Seq_K562_Human1.16429432
108P300_18555785_Chip-Seq_ESCs_Mouse1.15295504
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14781570
110SCL_19346495_ChIP-Seq_HPC-7_Human1.14646543
111P53_22387025_ChIP-Seq_ESCs_Mouse1.13865917
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13572375
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13488040
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13006590
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11603577
116P68_20966046_ChIP-Seq_HELA_Human1.11353270
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11257500
118RNF2_27304074_Chip-Seq_NSC_Mouse1.11207240
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10271337
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10264905
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.10143444
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09585176
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09263074
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09170856
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08881490
126MYB_26560356_Chip-Seq_TH1_Human1.08875676
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08684316
128IGF1R_20145208_ChIP-Seq_DFB_Human1.07767240
129* ETS1_20019798_ChIP-Seq_JURKAT_Human1.07242940
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06642977
131* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05853730
132PU1_27457419_Chip-Seq_LIVER_Mouse1.05501275
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04628048
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04338448
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03706994
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03685104
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.03160185
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03124054
139* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02737882
140OCT4_18555785_Chip-Seq_ESCs_Mouse1.02347602
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.02191901
142SA1_27219007_Chip-Seq_ERYTHROID_Human1.01896499
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01110458
144KLF4_18555785_Chip-Seq_ESCs_Mouse1.00733068
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00704349
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00612402
147MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99876013
148FOXP1_21924763_ChIP-Seq_HESCs_Human0.99109711
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.98661733
150RUNX_20019798_ChIP-Seq_JUKART_Human0.98587182
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.98079464
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.97902932
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97102722
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97102722
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97102722
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96124351
157* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95746710
158DCP1A_22483619_ChIP-Seq_HELA_Human0.95278318
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93628880
160CHD1_26751641_Chip-Seq_LNCaP_Human0.92989937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.91940609
2MP0001835_abnormal_antigen_presentation3.29938116
3MP0001986_abnormal_taste_sensitivity2.86574030
4MP0005671_abnormal_response_to2.84292208
5MP0008058_abnormal_DNA_repair2.51664916
6MP0004957_abnormal_blastocyst_morpholog2.49847644
7MP0008007_abnormal_cellular_replicative2.31064873
8MP0000015_abnormal_ear_pigmentation2.23970182
9MP0002254_reproductive_system_inflammat2.23391734
10MP0002163_abnormal_gland_morphology2.14767437
11MP0003763_abnormal_thymus_physiology2.11059492
12MP0002138_abnormal_hepatobiliary_system2.05482113
13MP0005387_immune_system_phenotype1.97243557
14MP0001790_abnormal_immune_system1.97243557
15MP0002148_abnormal_hypersensitivity_rea1.95513900
16MP0001188_hyperpigmentation1.91778760
17MP0002249_abnormal_larynx_morphology1.90158599
18MP0002277_abnormal_respiratory_mucosa1.89392497
19MP0005076_abnormal_cell_differentiation1.89309839
20MP0002132_abnormal_respiratory_system1.88057628
21MP0003787_abnormal_imprinting1.82464141
22MP0000685_abnormal_immune_system1.81642736
23MP0009785_altered_susceptibility_to1.79467982
24MP0004510_myositis1.78556032
25MP0001873_stomach_inflammation1.76225050
26MP0009278_abnormal_bone_marrow1.73465510
27MP0010030_abnormal_orbit_morphology1.71003511
28MP0005171_absent_coat_pigmentation1.70862414
29MP0005645_abnormal_hypothalamus_physiol1.68526876
30MP0001800_abnormal_humoral_immune1.68489928
31MP0010094_abnormal_chromosome_stability1.68185593
32MP0008057_abnormal_DNA_replication1.67183375
33MP0000350_abnormal_cell_proliferation1.66952345
34MP0005310_abnormal_salivary_gland1.63632238
35MP0003878_abnormal_ear_physiology1.60727803
36MP0005377_hearing/vestibular/ear_phenot1.60727803
37MP0009697_abnormal_copulation1.59275670
38MP0002653_abnormal_ependyma_morphology1.59192288
39MP0002396_abnormal_hematopoietic_system1.58408216
40MP0002452_abnormal_antigen_presenting1.57704341
41MP0001819_abnormal_immune_cell1.55751997
42MP0002009_preneoplasia1.54816409
43MP0002420_abnormal_adaptive_immunity1.54616976
44MP0008932_abnormal_embryonic_tissue1.54104701
45MP0008995_early_reproductive_senescence1.51247139
46MP0002877_abnormal_melanocyte_morpholog1.50179657
47MP0005000_abnormal_immune_tolerance1.48143252
48MP0005646_abnormal_pituitary_gland1.47705990
49MP0002160_abnormal_reproductive_system1.47514473
50MP0002398_abnormal_bone_marrow1.45749448
51MP0003786_premature_aging1.45461162
52MP0001730_embryonic_growth_arrest1.44575840
53MP0002095_abnormal_skin_pigmentation1.42916411
54MP0000372_irregular_coat_pigmentation1.40036931
55MP0002723_abnormal_immune_serum1.39697992
56MP0000678_abnormal_parathyroid_gland1.36121183
57MP0009333_abnormal_splenocyte_physiolog1.36004229
58MP0000313_abnormal_cell_death1.34071107
59MP0005174_abnormal_tail_pigmentation1.32510603
60MP0001697_abnormal_embryo_size1.32102972
61MP0005075_abnormal_melanosome_morpholog1.31897805
62MP0008877_abnormal_DNA_methylation1.31275080
63MP0003943_abnormal_hepatobiliary_system1.31118543
64MP0003436_decreased_susceptibility_to1.30781875
65MP0005380_embryogenesis_phenotype1.29897687
66MP0001672_abnormal_embryogenesis/_devel1.29897687
67MP0005025_abnormal_response_to1.29652452
68MP0000681_abnormal_thyroid_gland1.29647337
69MP0000566_synostosis1.29430371
70MP0000716_abnormal_immune_system1.28949627
71MP0008789_abnormal_olfactory_epithelium1.28705320
72MP0001919_abnormal_reproductive_system1.28337571
73MP0005389_reproductive_system_phenotype1.27992269
74MP0001348_abnormal_lacrimal_gland1.26662129
75MP0005379_endocrine/exocrine_gland_phen1.26541175
76MP0010307_abnormal_tumor_latency1.25425943
77MP0005397_hematopoietic_system_phenotyp1.24304890
78MP0001545_abnormal_hematopoietic_system1.24304890
79MP0002088_abnormal_embryonic_growth/wei1.24245063
80MP0003984_embryonic_growth_retardation1.23820738
81MP0002876_abnormal_thyroid_physiology1.20392288
82MP0003724_increased_susceptibility_to1.20011783
83MP0004808_abnormal_hematopoietic_stem1.19980249
84MP0002419_abnormal_innate_immunity1.19716939
85MP0003718_maternal_effect1.17711526
86MP0010386_abnormal_urinary_bladder1.17113964
87MP0002085_abnormal_embryonic_tissue1.16819608
88MP0002019_abnormal_tumor_incidence1.16395686
89MP0009672_abnormal_birth_weight1.14907770
90MP0002405_respiratory_system_inflammati1.13796277
91MP0000516_abnormal_urinary_system1.12717927
92MP0005367_renal/urinary_system_phenotyp1.12717927
93MP0000689_abnormal_spleen_morphology1.12123681
94MP0003077_abnormal_cell_cycle1.10627912
95MP0005408_hypopigmentation1.10466589
96MP0003693_abnormal_embryo_hatching1.09529319
97MP0002429_abnormal_blood_cell1.08763231
98MP0000049_abnormal_middle_ear1.08362060
99MP0002080_prenatal_lethality1.08008340
100MP0002166_altered_tumor_susceptibility1.07857114
101MP0002796_impaired_skin_barrier1.07305658
102MP0003136_yellow_coat_color1.07252233
103MP0004782_abnormal_surfactant_physiolog1.06611844
104MP0002751_abnormal_autonomic_nervous1.06035810
105MP0001119_abnormal_female_reproductive1.04820082
106MP0001346_abnormal_lacrimal_gland1.04115000
107MP0004197_abnormal_fetal_growth/weight/1.03399975
108MP0002210_abnormal_sex_determination1.03117431
109MP0000470_abnormal_stomach_morphology1.00340089
110MP0004381_abnormal_hair_follicle0.97710823
111MP0002722_abnormal_immune_system0.97594530
112MP0000631_abnormal_neuroendocrine_gland0.97275385
113MP0005464_abnormal_platelet_physiology0.96978575
114MP0008260_abnormal_autophagy0.96818969
115MP0000703_abnormal_thymus_morphology0.96471029
116MP0001293_anophthalmia0.95533925
117MP0003315_abnormal_perineum_morphology0.94977436
118MP0002006_tumorigenesis0.93511722
119MP0000490_abnormal_crypts_of0.93056749
120MP0002086_abnormal_extraembryonic_tissu0.92885582
121MP0003111_abnormal_nucleus_morphology0.92441209
122MP0005084_abnormal_gallbladder_morpholo0.91698242
123MP0004264_abnormal_extraembryonic_tissu0.88797161
124MP0002638_abnormal_pupillary_reflex0.88661952
125MP0005451_abnormal_body_composition0.88252994
126MP0005410_abnormal_fertilization0.87481742
127MP0001929_abnormal_gametogenesis0.86498033
128MP0005499_abnormal_olfactory_system0.86334585
129MP0005394_taste/olfaction_phenotype0.86334585
130MP0000613_abnormal_salivary_gland0.85390886
131MP0002084_abnormal_developmental_patter0.84717236
132MP0001186_pigmentation_phenotype0.84185651
133MP0003453_abnormal_keratinocyte_physiol0.84146028
134MP0002928_abnormal_bile_duct0.82855303
135MP0003303_peritoneal_inflammation0.80381937
136MP0002098_abnormal_vibrissa_morphology0.80084812
137MP0000858_altered_metastatic_potential0.79633199
138MP0003938_abnormal_ear_development0.79554009
139MP0006035_abnormal_mitochondrial_morpho0.79340529
140MP0002938_white_spotting0.77640048
141MP0002111_abnormal_tail_morphology0.75927407
142MP0009931_abnormal_skin_appearance0.74979903
143MP0001849_ear_inflammation0.74933718
144MP0005083_abnormal_biliary_tract0.74715671
145MP0009703_decreased_birth_body0.72256724
146MP0003567_abnormal_fetal_cardiomyocyte0.70915387
147MP0001145_abnormal_male_reproductive0.70668638
148MP0005501_abnormal_skin_physiology0.70219537
149MP0010155_abnormal_intestine_physiology0.69746528
150MP0000537_abnormal_urethra_morphology0.69573812
151MP0008961_abnormal_basal_metabolism0.69324544

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12468829
2Chromsome breakage (HP:0040012)3.82833413
3Reticulocytopenia (HP:0001896)3.17147173
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.03297751
5Type I transferrin isoform profile (HP:0003642)2.96001072
6Abnormal number of erythroid precursors (HP:0012131)2.95759276
7True hermaphroditism (HP:0010459)2.91822652
8Acute lymphatic leukemia (HP:0006721)2.86528402
9Clubbing of toes (HP:0100760)2.82095403
1011 pairs of ribs (HP:0000878)2.80513577
11Neoplasm of the adrenal cortex (HP:0100641)2.80049167
12Abnormality of the renal collecting system (HP:0004742)2.78515899
13Abnormality of cells of the erythroid lineage (HP:0012130)2.75916185
14Lymphopenia (HP:0001888)2.69636880
15Increased IgM level (HP:0003496)2.68071760
16Meckel diverticulum (HP:0002245)2.68044243
17Abnormality of the preputium (HP:0100587)2.67414450
18Duplicated collecting system (HP:0000081)2.67114832
19Optic neuritis (HP:0100653)2.65941712
20Retrobulbar optic neuritis (HP:0100654)2.65941712
21Gastrointestinal stroma tumor (HP:0100723)2.65600535
22Recurrent abscess formation (HP:0002722)2.63775587
23Hypothermia (HP:0002045)2.61560544
24Abnormal number of incisors (HP:0011064)2.58272149
25Septate vagina (HP:0001153)2.57162335
26Ectopic kidney (HP:0000086)2.55999205
27Squamous cell carcinoma (HP:0002860)2.55021071
28Osteomalacia (HP:0002749)2.51770189
29Abnormality of the ileum (HP:0001549)2.48824015
30Intestinal fistula (HP:0100819)2.47014181
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.46483404
32Type 2 muscle fiber atrophy (HP:0003554)2.46416985
33Abnormality of the labia minora (HP:0012880)2.40328066
34Obstructive lung disease (HP:0006536)2.40053472
35Chronic obstructive pulmonary disease (HP:0006510)2.40053472
36Recurrent viral infections (HP:0004429)2.38378755
37Meningitis (HP:0001287)2.37616520
38IgA deficiency (HP:0002720)2.35441278
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.29277215
40Muscle fiber atrophy (HP:0100295)2.27908831
41Agammaglobulinemia (HP:0004432)2.27790198
42Long eyelashes (HP:0000527)2.26383225
43Colon cancer (HP:0003003)2.25299139
44Short thumb (HP:0009778)2.23567457
45Hypochromic anemia (HP:0001931)2.21020701
46High anterior hairline (HP:0009890)2.17942107
47Absent thumb (HP:0009777)2.17710186
48Pallor (HP:0000980)2.17636808
49Encephalitis (HP:0002383)2.17629840
50Abnormality of chromosome stability (HP:0003220)2.14097307
51Long palpebral fissure (HP:0000637)2.13683663
52Myelodysplasia (HP:0002863)2.13272139
53Abnormality of the incisor (HP:0000676)2.11804698
54Myositis (HP:0100614)2.11089886
55Pancreatic cysts (HP:0001737)2.11047505
56Orchitis (HP:0100796)2.10780738
57Rectal fistula (HP:0100590)2.10121312
58Rectovaginal fistula (HP:0000143)2.10121312
59Bone marrow hypocellularity (HP:0005528)2.09951254
60Aplastic anemia (HP:0001915)2.09394758
61Bilateral microphthalmos (HP:0007633)2.09202168
62Recurrent bacterial skin infections (HP:0005406)2.08325321
63Abnormal lung lobation (HP:0002101)2.07797820
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05873950
65Reduced antithrombin III activity (HP:0001976)2.05358424
66Exertional dyspnea (HP:0002875)2.05212805
67Horseshoe kidney (HP:0000085)2.05161170
68Abnormality of cochlea (HP:0000375)2.03565817
69Increased IgE level (HP:0003212)2.00784929
70Abnormality of T cell physiology (HP:0011840)2.00311102
71Vaginal fistula (HP:0004320)1.99554088
72Abnormality of DNA repair (HP:0003254)1.98604440
73Amaurosis fugax (HP:0100576)1.98565293
74Hypergonadotropic hypogonadism (HP:0000815)1.98099254
75Breast hypoplasia (HP:0003187)1.97795969
76Abnormality of incisor morphology (HP:0011063)1.97780027
77Septo-optic dysplasia (HP:0100842)1.97450699
78Mediastinal lymphadenopathy (HP:0100721)1.96894461
79Abnormality of renal resorption (HP:0011038)1.96872511
80Rib fusion (HP:0000902)1.96782993
81Concave nail (HP:0001598)1.95751013
82Broad distal phalanx of finger (HP:0009836)1.95132652
83Birth length less than 3rd percentile (HP:0003561)1.94257575
84Deep palmar crease (HP:0006191)1.93312948
85Urethral obstruction (HP:0000796)1.91870499
86Recurrent pneumonia (HP:0006532)1.89516083
87Tracheoesophageal fistula (HP:0002575)1.88928991
88Basal cell carcinoma (HP:0002671)1.87968551
89Selective tooth agenesis (HP:0001592)1.87918419
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87901206
91Petechiae (HP:0000967)1.87834924
92White forelock (HP:0002211)1.87151781
93Renal Fanconi syndrome (HP:0001994)1.87026085
94Stomatitis (HP:0010280)1.86884918
95Pulmonary fibrosis (HP:0002206)1.86353720
96Sloping forehead (HP:0000340)1.86322448
97Abnormality of dental color (HP:0011073)1.86021857
98IgG deficiency (HP:0004315)1.86001301
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.85390669
100Absent/shortened dynein arms (HP:0200106)1.85390669
101Patellar aplasia (HP:0006443)1.84760345
102Abnormality of the parietal bone (HP:0002696)1.84668588
103Optic nerve coloboma (HP:0000588)1.84642103
104Abnormality of the carotid arteries (HP:0005344)1.84530794
105Partial duplication of thumb phalanx (HP:0009944)1.84478405
106Microvesicular hepatic steatosis (HP:0001414)1.84419822
107Chronic mucocutaneous candidiasis (HP:0002728)1.84195348
108Recurrent cutaneous fungal infections (HP:0011370)1.84195348
109Duodenal stenosis (HP:0100867)1.83987668
110Small intestinal stenosis (HP:0012848)1.83987668
111Aplasia/Hypoplasia of the thymus (HP:0010515)1.83877517
112Patchy hypopigmentation of hair (HP:0011365)1.83813111
113Absent radius (HP:0003974)1.83361901
114Abnormal hair whorl (HP:0010721)1.78980004
115Lymphoma (HP:0002665)1.78622903
116Absent forearm bone (HP:0003953)1.78619403
117Aplasia involving forearm bones (HP:0009822)1.78619403
118Renal tubular dysfunction (HP:0000124)1.78036496
119Atresia of the external auditory canal (HP:0000413)1.77143166
120Panhypogammaglobulinemia (HP:0003139)1.76534870
121Keratitis (HP:0000491)1.76528031
122Vasculitis (HP:0002633)1.76524707
123Thyroiditis (HP:0100646)1.76483021
124Granulocytopenia (HP:0001913)1.76315532
125Recurrent fungal infections (HP:0002841)1.76038837
126Leukopenia (HP:0001882)1.75543886
127Optic nerve hypoplasia (HP:0000609)1.75531037
128IgM deficiency (HP:0002850)1.75332374
129Alveolar cell carcinoma (HP:0006519)1.74434357
130Aplasia/Hypoplasia of the patella (HP:0006498)1.74334862
131Preaxial hand polydactyly (HP:0001177)1.73757139
132Severe combined immunodeficiency (HP:0004430)1.73396010
133Respiratory difficulties (HP:0002880)1.72871862
134Testicular atrophy (HP:0000029)1.71875742
135Cleft eyelid (HP:0000625)1.71726370
136Hypoplasia of the pons (HP:0012110)1.71412363
137Abnormality of the duodenum (HP:0002246)1.71357198
138Abnormality of the septum pellucidum (HP:0007375)1.70741150
139Trigonocephaly (HP:0000243)1.70651516
1403-Methylglutaconic aciduria (HP:0003535)1.69975451
141Nephroblastoma (Wilms tumor) (HP:0002667)1.69816067
142Abnormality of homocysteine metabolism (HP:0010919)1.69598103
143Homocystinuria (HP:0002156)1.69598103
144Cheilitis (HP:0100825)1.69532994
145Absent septum pellucidum (HP:0001331)1.69325651
146Prolonged bleeding time (HP:0003010)1.69180196
147Abnormality of the intervertebral disk (HP:0005108)1.68013353
148Neutropenia (HP:0001875)1.67996515
149Pancreatic fibrosis (HP:0100732)1.67591987
150Glomerulopathy (HP:0100820)1.67238381
151Intestinal atresia (HP:0011100)1.67031201
152Eosinophilia (HP:0001880)1.67005486
153Keratoconjunctivitis sicca (HP:0001097)1.66955389
154Premature graying of hair (HP:0002216)1.66691657
155B lymphocytopenia (HP:0010976)1.66130571
156Abnormality of B cell number (HP:0010975)1.66130571
157Morphological abnormality of the inner ear (HP:0011390)1.66123983
158Esophageal atresia (HP:0002032)1.65859737
159Abnormality of the thymus (HP:0000777)1.65456252
160Slow-growing hair (HP:0002217)1.65207836
161Abnormality of hair growth rate (HP:0011363)1.65207836
162Facial hemangioma (HP:0000329)1.65090735
163Pulmonary infiltrates (HP:0002113)1.64647993
164Abnormality of nail color (HP:0100643)1.64451170
165Cafe-au-lait spot (HP:0000957)1.64306962
166Skull defect (HP:0001362)1.64254114
167Eczematoid dermatitis (HP:0000976)1.64229343
168Abnormality of the fingertips (HP:0001211)1.62809411
169Triphalangeal thumb (HP:0001199)1.62431642
170Embryonal renal neoplasm (HP:0011794)1.62431356
171Spinal cord lesions (HP:0100561)1.62265286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.40292323
2VRK24.04917705
3PRPF4B3.67527900
4CASK3.18263081
5MAP3K103.12182701
6SIK13.03283839
7MAP3K143.01079836
8TRIB32.87830555
9TXK2.79166825
10TAF12.41907814
11MKNK22.40090906
12AKT32.38384452
13IRAK42.36626312
14SRPK12.36086086
15MKNK12.32442181
16SIK31.90690122
17MAP4K11.90312186
18ZAK1.88163144
19PLK41.86175237
20BMPR21.84917574
21STK161.78931060
22CDK121.74143963
23IKBKB1.71207850
24YES11.68089679
25NME11.67634578
26NUAK11.65350072
27MAP2K71.64706568
28EEF2K1.63933226
29SIK21.63108320
30BMPR1B1.63017722
31CAMK1D1.57214458
32EPHA31.57084302
33SGK21.55815660
34IKBKE1.49629235
35MAPK131.46878159
36IRAK31.46321517
37JAK31.46048253
38VRK11.44639125
39EIF2AK21.44025442
40PIM21.42031998
41CDK81.38691944
42TLK11.35718457
43CHUK1.35159677
44BRAF1.34829857
45MST41.32741323
46MUSK1.30811788
47ACVR1B1.28627153
48STK38L1.28350262
49KIT1.25522836
50PIM11.25317976
51TEC1.24681265
52TNIK1.20723576
53WEE11.16399186
54CLK11.16391925
55RPS6KA61.15247398
56CHEK21.13974214
57TTK1.13871550
58ERBB31.12146847
59TAOK21.11248326
60TRPM71.10371767
61CAMK1G1.10207786
62RPS6KC11.08980946
63RPS6KL11.08980946
64ADRBK21.08201833
65RIPK41.06304425
66FGFR21.05070145
67MAP3K121.03276038
68TYK21.00691883
69NEK21.00646611
70NLK1.00488217
71CDK40.99940423
72ERN10.96843441
73MAP2K30.95967508
74IRAK10.94341864
75PKN20.93339032
76BTK0.92994876
77GRK10.88828201
78BCKDK0.85308949
79FGFR30.83507494
80EIF2AK30.82525952
81TAOK10.82279450
82SGK30.81728584
83SYK0.81253044
84MELK0.78595118
85HIPK20.77901623
86CHEK10.77187865
87RPS6KB20.76937887
88NEK90.76189354
89MARK30.75701967
90ICK0.74682479
91CDK30.73751449
92TSSK60.73462419
93BUB10.73456955
94LYN0.69965153
95STK240.69809320
96IRAK20.69073083
97PRKCI0.68167407
98SGK2230.66430547
99SGK4940.66430547
100ATR0.65691652
101EIF2AK10.65517911
102RPS6KA20.64876806
103NEK10.64531499
104MAP3K130.63920840
105RPS6KB10.63115438
106FGFR40.63030818
107NEK60.62420067
108TESK20.60912849
109EPHA20.60451378
110TGFBR10.59858746
111MTOR0.59279831
112PASK0.57921016
113BLK0.57428897
114PLK10.57395231
115FLT30.57339789
116ZAP700.56542570
117DYRK30.55395362
118PLK30.55295724
119PRKD20.54950578
120MAP3K80.53760763
121AURKB0.53391521
122RPS6KA50.52952187
123ALK0.52501971
124JAK10.52293833
125TRIM280.52092527
126CDK70.51022680
127RPS6KA40.49194355
128PTK60.48570551
129RPS6KA10.47849081
130TNK20.46535418
131PINK10.46424737
132LCK0.45806841
133ARAF0.45653697
134TAOK30.45636864
135STK100.45084264
136MARK20.44821223
137MAPKAPK20.44676931
138CDK20.44401168
139CDK90.44014422
140STK40.43974102
141CSF1R0.43505955
142BRSK20.43028820
143CCNB10.42224286
144ATM0.42177865
145MYLK0.41932036
146CDC70.40809193
147BRD40.39585886
148NME20.39567878
149CDC42BPA0.39240639
150TBK10.37781991
151PRKCQ0.37515695
152DYRK20.37239835
153MAP2K60.36099765

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.16734361
2Fanconi anemia pathway_Homo sapiens_hsa034602.76711493
3Primary immunodeficiency_Homo sapiens_hsa053402.43466944
4DNA replication_Homo sapiens_hsa030302.40887281
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.39696984
6RNA polymerase_Homo sapiens_hsa030202.35007875
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29950232
8Base excision repair_Homo sapiens_hsa034102.23040262
9Protein export_Homo sapiens_hsa030602.18463760
10Allograft rejection_Homo sapiens_hsa053302.02142365
11Non-homologous end-joining_Homo sapiens_hsa034501.97303776
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.88346954
13Basal transcription factors_Homo sapiens_hsa030221.86390652
14RNA degradation_Homo sapiens_hsa030181.75466144
15Measles_Homo sapiens_hsa051621.71378439
16Autoimmune thyroid disease_Homo sapiens_hsa053201.70810529
17Mismatch repair_Homo sapiens_hsa034301.70349215
18Systemic lupus erythematosus_Homo sapiens_hsa053221.56643141
19Pyrimidine metabolism_Homo sapiens_hsa002401.53949227
20Spliceosome_Homo sapiens_hsa030401.53877870
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52518150
22Graft-versus-host disease_Homo sapiens_hsa053321.51211748
23Nucleotide excision repair_Homo sapiens_hsa034201.49702343
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44041979
25Herpes simplex infection_Homo sapiens_hsa051681.42777983
26Other glycan degradation_Homo sapiens_hsa005111.37437921
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34108759
28Cell cycle_Homo sapiens_hsa041101.31749655
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24251317
30Basal cell carcinoma_Homo sapiens_hsa052171.22308122
31Lysine degradation_Homo sapiens_hsa003101.20141492
32Antigen processing and presentation_Homo sapiens_hsa046121.18756033
33Ribosome_Homo sapiens_hsa030101.18047256
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15824806
35Sulfur relay system_Homo sapiens_hsa041221.15465848
36Proteasome_Homo sapiens_hsa030501.15413998
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14811977
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.14692424
39One carbon pool by folate_Homo sapiens_hsa006701.14011632
40Hematopoietic cell lineage_Homo sapiens_hsa046401.12444739
41mRNA surveillance pathway_Homo sapiens_hsa030151.12105224
42Purine metabolism_Homo sapiens_hsa002301.10253283
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09306520
44Leishmaniasis_Homo sapiens_hsa051401.09036131
45Influenza A_Homo sapiens_hsa051641.07873945
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06628113
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04620961
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02720795
49Arachidonic acid metabolism_Homo sapiens_hsa005901.00946859
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00705576
51Hedgehog signaling pathway_Homo sapiens_hsa043401.00317103
52p53 signaling pathway_Homo sapiens_hsa041151.00269010
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97015089
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95941134
55Colorectal cancer_Homo sapiens_hsa052100.95912130
56Epstein-Barr virus infection_Homo sapiens_hsa051690.91961509
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91831929
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91189449
59Non-small cell lung cancer_Homo sapiens_hsa052230.91079315
60Asthma_Homo sapiens_hsa053100.90180004
61RNA transport_Homo sapiens_hsa030130.89641419
62Selenocompound metabolism_Homo sapiens_hsa004500.89402761
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87493670
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86440249
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.85109450
66Hepatitis B_Homo sapiens_hsa051610.82296219
67Apoptosis_Homo sapiens_hsa042100.81815884
68T cell receptor signaling pathway_Homo sapiens_hsa046600.81345807
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80405553
70Legionellosis_Homo sapiens_hsa051340.79432376
71Shigellosis_Homo sapiens_hsa051310.77642676
72Type I diabetes mellitus_Homo sapiens_hsa049400.77108341
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76817265
74HTLV-I infection_Homo sapiens_hsa051660.76073240
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75323400
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.73292259
77Prolactin signaling pathway_Homo sapiens_hsa049170.72392074
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71865123
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71400617
80Rheumatoid arthritis_Homo sapiens_hsa053230.71196260
81Alcoholism_Homo sapiens_hsa050340.70180131
82Regulation of autophagy_Homo sapiens_hsa041400.69715358
83Chemokine signaling pathway_Homo sapiens_hsa040620.68281362
84B cell receptor signaling pathway_Homo sapiens_hsa046620.68203812
85Toxoplasmosis_Homo sapiens_hsa051450.68173272
86Notch signaling pathway_Homo sapiens_hsa043300.67010511
87Viral myocarditis_Homo sapiens_hsa054160.66408489
88N-Glycan biosynthesis_Homo sapiens_hsa005100.65536299
89Bladder cancer_Homo sapiens_hsa052190.65293675
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63340217
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63066575
92Vitamin B6 metabolism_Homo sapiens_hsa007500.62878676
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.62708766
94Acute myeloid leukemia_Homo sapiens_hsa052210.62648256
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61897920
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61016567
97Malaria_Homo sapiens_hsa051440.59724487
98mTOR signaling pathway_Homo sapiens_hsa041500.59492222
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58985612
100Thyroid cancer_Homo sapiens_hsa052160.57896509
101TNF signaling pathway_Homo sapiens_hsa046680.56862929
102Osteoclast differentiation_Homo sapiens_hsa043800.54514677
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50620860
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48247468
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47246587
106Sphingolipid metabolism_Homo sapiens_hsa006000.46871227
107Tuberculosis_Homo sapiens_hsa051520.46832350
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45567706
109VEGF signaling pathway_Homo sapiens_hsa043700.44535234
110Prostate cancer_Homo sapiens_hsa052150.43610210
111Pertussis_Homo sapiens_hsa051330.43475425
112Wnt signaling pathway_Homo sapiens_hsa043100.43064999
113Renal cell carcinoma_Homo sapiens_hsa052110.42989383
114Endometrial cancer_Homo sapiens_hsa052130.42702784
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.42525161
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41247849
117FoxO signaling pathway_Homo sapiens_hsa040680.40293808
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39714673
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39474803
120Viral carcinogenesis_Homo sapiens_hsa052030.39348646
121Hepatitis C_Homo sapiens_hsa051600.39077117
122Salmonella infection_Homo sapiens_hsa051320.37450356
123HIF-1 signaling pathway_Homo sapiens_hsa040660.37119213
124Small cell lung cancer_Homo sapiens_hsa052220.36796952
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.35984507
126Melanoma_Homo sapiens_hsa052180.34264105
127Dorso-ventral axis formation_Homo sapiens_hsa043200.32914686
128Taste transduction_Homo sapiens_hsa047420.32249145
129Huntingtons disease_Homo sapiens_hsa050160.31967449
130Choline metabolism in cancer_Homo sapiens_hsa052310.31676669
131Pancreatic cancer_Homo sapiens_hsa052120.30437220
132MicroRNAs in cancer_Homo sapiens_hsa052060.30385797
133Phagosome_Homo sapiens_hsa041450.30040526
134Ether lipid metabolism_Homo sapiens_hsa005650.29966250

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »