FBXO42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.04973639
2pyrimidine nucleobase catabolic process (GO:0006208)4.90045165
3neural tube formation (GO:0001841)4.74984740
4protein localization to kinetochore (GO:0034501)4.54030460
5adaptation of signaling pathway (GO:0023058)4.53968311
6intraciliary transport (GO:0042073)4.53761469
7negative regulation of histone methylation (GO:0031061)4.50970670
8DNA unwinding involved in DNA replication (GO:0006268)4.45433892
9neuronal action potential propagation (GO:0019227)4.41927659
10DNA double-strand break processing (GO:0000729)4.32782113
11nuclear pore complex assembly (GO:0051292)4.23924213
12glial cell proliferation (GO:0014009)4.19857875
13nuclear pore organization (GO:0006999)4.11513755
14mitotic chromosome condensation (GO:0007076)3.95218765
15limb bud formation (GO:0060174)3.92489901
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.88474363
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.88474363
18regulation of translation, ncRNA-mediated (GO:0045974)3.88474363
19heterochromatin organization (GO:0070828)3.88078389
20protein localization to chromosome, centromeric region (GO:0071459)3.86517675
21mitotic nuclear envelope disassembly (GO:0007077)3.81416614
22positive regulation of mitochondrial fission (GO:0090141)3.71387851
23membrane disassembly (GO:0030397)3.71218453
24nuclear envelope disassembly (GO:0051081)3.71218453
25regulation of translational termination (GO:0006449)3.68807478
26DNA replication-dependent nucleosome assembly (GO:0006335)3.63615233
27DNA replication-dependent nucleosome organization (GO:0034723)3.63615233
28histone H2A acetylation (GO:0043968)3.62972573
29histone H2A monoubiquitination (GO:0035518)3.58969858
30peptidyl-arginine omega-N-methylation (GO:0035247)3.58551899
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55975559
32nucleobase catabolic process (GO:0046113)3.54363576
33regulation of hippo signaling (GO:0035330)3.52771677
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.52289930
35intracellular estrogen receptor signaling pathway (GO:0030520)3.47558090
36replication fork processing (GO:0031297)3.46366288
37seminiferous tubule development (GO:0072520)3.46226548
38regulation of posttranscriptional gene silencing (GO:0060147)3.44047783
39regulation of gene silencing by miRNA (GO:0060964)3.44047783
40regulation of gene silencing by RNA (GO:0060966)3.44047783
41folic acid-containing compound biosynthetic process (GO:0009396)3.43891382
42peptidyl-arginine methylation (GO:0018216)3.43855083
43peptidyl-arginine N-methylation (GO:0035246)3.43855083
44mitotic sister chromatid segregation (GO:0000070)3.41434050
45regulation of telomere maintenance (GO:0032204)3.34759626
46sister chromatid segregation (GO:0000819)3.34251209
47head development (GO:0060322)3.32170650
48dosage compensation (GO:0007549)3.31630869
49axonal fasciculation (GO:0007413)3.29038220
50chromatin assembly (GO:0031497)3.24874242
51regulation of translational fidelity (GO:0006450)3.23032688
52pore complex assembly (GO:0046931)3.22050809
53regulation of histone H3-K9 methylation (GO:0051570)3.21161565
54regulation of sister chromatid cohesion (GO:0007063)3.21066302
55snRNA transcription (GO:0009301)3.21051520
56synapse assembly (GO:0007416)3.20650907
57regulation of RNA export from nucleus (GO:0046831)3.18614479
58presynaptic membrane organization (GO:0097090)3.16372985
59histone H4-K5 acetylation (GO:0043981)3.14815387
60histone H4-K8 acetylation (GO:0043982)3.14815387
61neuron cell-cell adhesion (GO:0007158)3.14316427
62nonmotile primary cilium assembly (GO:0035058)3.13777616
63cardiac ventricle formation (GO:0003211)3.13697790
64olfactory bulb development (GO:0021772)3.13508160
65histone arginine methylation (GO:0034969)3.12090210
66NLS-bearing protein import into nucleus (GO:0006607)3.10507632
67protein localization to chromosome (GO:0034502)3.08448957
68peptidyl-lysine dimethylation (GO:0018027)3.08354621
69DNA duplex unwinding (GO:0032508)3.08047051
70postsynaptic membrane organization (GO:0001941)3.07785961
71histone H3-K4 trimethylation (GO:0080182)3.07166967
72DNA replication initiation (GO:0006270)3.07095628
73DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.06766756
74protein K11-linked deubiquitination (GO:0035871)3.05841690
75response to pheromone (GO:0019236)3.05459859
76regulation of chromatin binding (GO:0035561)3.05388885
77nuclear envelope organization (GO:0006998)3.05164471
78DNA geometric change (GO:0032392)3.04839689
79gene silencing by RNA (GO:0031047)3.03972950
80mitotic sister chromatid cohesion (GO:0007064)3.02203146
81regulation of telomere maintenance via telomerase (GO:0032210)3.01627470
82somite development (GO:0061053)3.00657037
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97350088
84positive regulation of chromosome segregation (GO:0051984)2.97293881
85DNA integration (GO:0015074)2.96795855
86auditory behavior (GO:0031223)2.96695942
87histone H4-K12 acetylation (GO:0043983)2.94273838
88gamma-aminobutyric acid transport (GO:0015812)2.93983209
89regulation of heat generation (GO:0031650)2.93856179
90DNA damage response, signal transduction resulting in transcription (GO:0042772)2.93594684
91positive regulation of SMAD protein import into nucleus (GO:0060391)2.93500573
92centriole replication (GO:0007099)2.92662510
93mechanosensory behavior (GO:0007638)2.92492160
94glucocorticoid receptor signaling pathway (GO:0042921)2.91979443
95gene silencing (GO:0016458)2.88863848
96piRNA metabolic process (GO:0034587)2.86500770
97cornea development in camera-type eye (GO:0061303)2.86130339
98substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.85804884
99substrate-independent telencephalic tangential migration (GO:0021826)2.85804884
100histone H3-K9 methylation (GO:0051567)2.85633557
101attachment of spindle microtubules to kinetochore (GO:0008608)2.85251100
102protein localization to cilium (GO:0061512)2.85195254
103mRNA stabilization (GO:0048255)2.84355624
104RNA stabilization (GO:0043489)2.84355624
105glycerophospholipid catabolic process (GO:0046475)2.82225945
106histone H4-K16 acetylation (GO:0043984)2.81522061
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81189266
108preassembly of GPI anchor in ER membrane (GO:0016254)2.81096307
109calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.80932771
110cardiac chamber formation (GO:0003207)2.80814297
111negative regulation of cAMP-mediated signaling (GO:0043951)2.80689796
112positive regulation of action potential (GO:0045760)2.78778621
113corticosteroid receptor signaling pathway (GO:0031958)2.78078041
114cilium morphogenesis (GO:0060271)2.77767663
115negative regulation of histone modification (GO:0031057)2.76506963
116negative regulation of Rho protein signal transduction (GO:0035024)2.75786724
117positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.75405284
118mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.75405284
119regulation of spindle organization (GO:0090224)2.73695990
120cerebral cortex radially oriented cell migration (GO:0021799)2.73027082
121establishment of protein localization to Golgi (GO:0072600)2.72747963
122intra-Golgi vesicle-mediated transport (GO:0006891)2.72101726
123DNA replication checkpoint (GO:0000076)2.71886268
124regulation of DNA damage checkpoint (GO:2000001)2.71500955
125adult walking behavior (GO:0007628)2.70280426
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69948218
127epithelial cell differentiation involved in kidney development (GO:0035850)2.69440648
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.68407297
129peptidyl-lysine trimethylation (GO:0018023)2.68139320
130regulation of collateral sprouting (GO:0048670)2.67320069
131synaptic transmission, cholinergic (GO:0007271)2.67140716
132protein localization to synapse (GO:0035418)2.66597338
133negative regulation of histone acetylation (GO:0035067)2.66176590
134retinal cone cell development (GO:0046549)2.65630353
135cilium organization (GO:0044782)2.65613245
136translesion synthesis (GO:0019985)2.64835250
137negative regulation of axon guidance (GO:1902668)2.64697064
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64636515
139epithelial cilium movement (GO:0003351)2.63928502
140trophectodermal cell differentiation (GO:0001829)2.63762018
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.63478040
142cilium assembly (GO:0042384)2.63173723
143regulation of nucleobase-containing compound transport (GO:0032239)2.62979740
144microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.62865099
145DNA methylation involved in gamete generation (GO:0043046)2.62685088
146regulation of acyl-CoA biosynthetic process (GO:0050812)2.62512980
1473-UTR-mediated mRNA stabilization (GO:0070935)2.62248678
148DNA strand elongation involved in DNA replication (GO:0006271)2.61491607
149protein polyglutamylation (GO:0018095)2.61418783
150L-alpha-amino acid transmembrane transport (GO:1902475)2.61298001
151phosphatidylethanolamine metabolic process (GO:0046337)2.60540459
152long-chain fatty acid biosynthetic process (GO:0042759)2.60223287
153glycosphingolipid biosynthetic process (GO:0006688)2.59044599
154regulation of action potential (GO:0098900)2.58259994
155negative regulation of chromatin modification (GO:1903309)2.56895886
156sympathetic nervous system development (GO:0048485)2.56318793
157histone H3-K9 modification (GO:0061647)2.54271180
158regulation of chromosome segregation (GO:0051983)2.53205993
159negative regulation of telomere maintenance (GO:0032205)2.52500457
160mitotic G1 DNA damage checkpoint (GO:0031571)2.52100996
161chromatin assembly or disassembly (GO:0006333)2.51937769
162regulation of centriole replication (GO:0046599)2.51760082
163mitotic metaphase plate congression (GO:0007080)2.51519070
164presynaptic membrane assembly (GO:0097105)2.50967123
165negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50593664
166negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.50593664
167nucleosome disassembly (GO:0006337)2.49217632
168protein-DNA complex disassembly (GO:0032986)2.49217632
169positive regulation of cardiac muscle cell differentiation (GO:2000727)2.47970054
170keratinocyte development (GO:0003334)2.46765455
171negative regulation of gene expression, epigenetic (GO:0045814)2.46611086
172negative regulation of glial cell proliferation (GO:0060253)2.46285336
173chromatin silencing (GO:0006342)2.46248226
174chromosome condensation (GO:0030261)2.45052861
175C-terminal protein amino acid modification (GO:0018410)2.44824098
176regulation of mitotic spindle organization (GO:0060236)2.44688279
177photoreceptor cell maintenance (GO:0045494)2.44300869
178positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.43948280
179positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43948280
180positive regulation of mitotic sister chromatid separation (GO:1901970)2.43948280
181axoneme assembly (GO:0035082)2.43646283
182mRNA transport (GO:0051028)2.42467093
183negative regulation of DNA recombination (GO:0045910)2.42210232
184histone H2A ubiquitination (GO:0033522)2.41409594
185positive regulation of gene expression, epigenetic (GO:0045815)2.40369380
186inositol phosphate catabolic process (GO:0071545)2.40277653
187histone H3-K4 methylation (GO:0051568)2.40107284
188negative regulation of meiosis (GO:0045835)2.39959840
189regulation of neurotransmitter uptake (GO:0051580)2.39846705
190pyrimidine dimer repair (GO:0006290)2.39796587
191snRNA processing (GO:0016180)2.39673378
192interkinetic nuclear migration (GO:0022027)2.38532508
193central nervous system neuron axonogenesis (GO:0021955)2.38376340
194neuron recognition (GO:0008038)2.37769662
195regulation of sulfur metabolic process (GO:0042762)2.36965080
196central nervous system projection neuron axonogenesis (GO:0021952)2.35752718
197protein targeting to Golgi (GO:0000042)2.35410476
198limb development (GO:0060173)2.34302475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55260509
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67606828
3GBX2_23144817_ChIP-Seq_PC3_Human3.89821684
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.53406209
5EZH2_22144423_ChIP-Seq_EOC_Human3.48105463
6MYC_22102868_ChIP-Seq_BL_Human3.39004815
7POU3F2_20337985_ChIP-ChIP_501MEL_Human3.24232579
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04636834
9ZNF274_21170338_ChIP-Seq_K562_Hela3.01947766
10IGF1R_20145208_ChIP-Seq_DFB_Human2.93814393
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81966979
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75602913
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74355861
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69813663
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68048471
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55231038
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42350159
18VDR_22108803_ChIP-Seq_LS180_Human2.28985667
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28532017
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.23973556
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21235342
22ZNF263_19887448_ChIP-Seq_K562_Human2.16555789
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14100482
24FUS_26573619_Chip-Seq_HEK293_Human2.12848787
25TAF15_26573619_Chip-Seq_HEK293_Human2.09660927
26* KDM2B_26808549_Chip-Seq_DND41_Human2.08983776
27VDR_21846776_ChIP-Seq_THP-1_Human2.07261945
28ER_23166858_ChIP-Seq_MCF-7_Human2.06258833
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05117002
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02030187
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01572671
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01164897
33P300_19829295_ChIP-Seq_ESCs_Human2.00349988
34EWS_26573619_Chip-Seq_HEK293_Human1.95946843
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92404494
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.92132238
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88973481
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88735206
39TCF7_22412390_ChIP-Seq_EML_Mouse1.87664167
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87043026
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.86330890
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83750539
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.82824668
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81955389
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81741418
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80939225
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77928843
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76811820
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76497736
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75708330
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74318315
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73477799
53CIITA_25753668_ChIP-Seq_RAJI_Human1.73031532
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72026678
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71198294
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70020612
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69877459
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67510058
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66699946
60AR_21909140_ChIP-Seq_LNCAP_Human1.66179204
61STAT3_23295773_ChIP-Seq_U87_Human1.65414712
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65308362
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61225873
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59713157
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58032437
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56964739
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56531761
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54222448
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.53405457
70* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52979859
71* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51794207
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.51534266
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.50797552
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48366601
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48295780
76TCF4_23295773_ChIP-Seq_U87_Human1.47758385
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47385342
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47083825
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46771523
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46542102
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.46298680
82* XRN2_22483619_ChIP-Seq_HELA_Human1.45923431
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44888598
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44172601
85REST_21632747_ChIP-Seq_MESCs_Mouse1.43422540
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43027685
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.42808060
88KDM2B_26808549_Chip-Seq_K562_Human1.42007782
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41808099
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41608956
91AR_25329375_ChIP-Seq_VCAP_Human1.39423134
92* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38633004
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38047014
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.37590750
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37133825
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36402593
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36140210
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.35590440
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35458978
100* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35192329
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34697715
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34613353
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33961396
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.33101515
105KDM5A_27292631_Chip-Seq_BREAST_Human1.33001821
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32879706
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.32751996
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31950837
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31357375
110RNF2_27304074_Chip-Seq_NSC_Mouse1.30774488
111* UTX_26944678_Chip-Seq_JUKART_Human1.29942726
112ATF3_27146783_Chip-Seq_COLON_Human1.29850906
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27105124
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26254090
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26084438
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25697439
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24965184
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.24247386
119TFEB_21752829_ChIP-Seq_HELA_Human1.21788432
120TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21385838
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20856930
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20609095
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20193662
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20193662
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19074553
126IRF1_19129219_ChIP-ChIP_H3396_Human1.18679679
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18305938
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17834814
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.17592818
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16553542
131TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15597943
132LXR_22292898_ChIP-Seq_THP-1_Human1.15330207
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14878899
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13868177
135ELK1_19687146_ChIP-ChIP_HELA_Human1.13716233
136PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13204599
137* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12890499
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.12441418
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11265495
140ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11174981
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10954800
142* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10673109
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10565648
144* CREB1_26743006_Chip-Seq_LNCaP_Human1.09854378
145KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09840428
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09457465
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09164738
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.08933991
149STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08242218
150SOX9_26525672_Chip-Seq_HEART_Mouse1.07883498
151CBP_20019798_ChIP-Seq_JUKART_Human1.07782595
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07782595
153TCF4_22108803_ChIP-Seq_LS180_Human1.07429836
154* MAF_26560356_Chip-Seq_TH1_Human1.07392081
155SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06709187
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06642759
157TP53_16413492_ChIP-PET_HCT116_Human1.06079463
158GATA1_26923725_Chip-Seq_HPCs_Mouse1.05957276
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05932091
160P53_22387025_ChIP-Seq_ESCs_Mouse1.05457550
161* JUN_21703547_ChIP-Seq_K562_Human1.04789585
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04476379
163BCAT_22108803_ChIP-Seq_LS180_Human1.03722705
164OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03111123
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02242366
166TP53_22573176_ChIP-Seq_HFKS_Human1.02072916
167* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01537432
168* TBL1_22424771_ChIP-Seq_293T_Human1.01149771
169E2F1_18555785_Chip-Seq_ESCs_Mouse1.01016908
170REST_18959480_ChIP-ChIP_MESCs_Mouse1.00870534
171* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00723691
172TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00616437
173EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00581169
174NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00498847
175HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99952911
176* RACK7_27058665_Chip-Seq_MCF-7_Human0.99800678
177KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99514702
178KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99514702
179KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99514702
180* NCOR1_26117541_ChIP-Seq_K562_Human0.99222714
181AR_21572438_ChIP-Seq_LNCaP_Human0.99144245
182EST1_17652178_ChIP-ChIP_JURKAT_Human0.99062389
183SMAD_19615063_ChIP-ChIP_OVARY_Human0.98129723
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97261286
185PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97087385
186* GABP_19822575_ChIP-Seq_HepG2_Human0.96378980
187POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95809464
188ELF1_20517297_ChIP-Seq_JURKAT_Human0.95805738
189* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95141632
190TAL1_26923725_Chip-Seq_HPCs_Mouse0.95090787
191SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93713138
192SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92030622
193* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91491938
194P68_20966046_ChIP-Seq_HELA_Human0.90408872
195CHD1_26751641_Chip-Seq_LNCaP_Human0.90374550
196THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89086729
197* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88582750
198CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86360854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.46054313
2MP0005076_abnormal_cell_differentiation3.27085035
3MP0003123_paternal_imprinting3.04759850
4MP0004147_increased_porphyrin_level2.98263940
5MP0010094_abnormal_chromosome_stability2.89635666
6MP0003693_abnormal_embryo_hatching2.88281279
7MP0003077_abnormal_cell_cycle2.77947293
8MP0010352_gastrointestinal_tract_polyps2.72845314
9MP0010030_abnormal_orbit_morphology2.65484226
10MP0001984_abnormal_olfaction2.60423690
11MP0004957_abnormal_blastocyst_morpholog2.58435341
12MP0003705_abnormal_hypodermis_morpholog2.51070162
13MP0008995_early_reproductive_senescence2.45458785
14MP0003121_genomic_imprinting2.43780771
15MP0001529_abnormal_vocalization2.42109990
16MP0002653_abnormal_ependyma_morphology2.30994413
17MP0003011_delayed_dark_adaptation2.29535096
18MP0008057_abnormal_DNA_replication2.27202969
19MP0001730_embryonic_growth_arrest2.23151970
20MP0000350_abnormal_cell_proliferation2.14641084
21MP0010307_abnormal_tumor_latency2.12561940
22MP0002822_catalepsy2.04473492
23MP0005253_abnormal_eye_physiology2.02806167
24MP0006072_abnormal_retinal_apoptosis1.94908981
25MP0003646_muscle_fatigue1.93938592
26MP0002084_abnormal_developmental_patter1.93738508
27MP0000015_abnormal_ear_pigmentation1.92616665
28MP0005367_renal/urinary_system_phenotyp1.91540137
29MP0000516_abnormal_urinary_system1.91540137
30MP0000778_abnormal_nervous_system1.90801463
31MP0001849_ear_inflammation1.88523856
32MP0002085_abnormal_embryonic_tissue1.88138819
33MP0001697_abnormal_embryo_size1.86758591
34MP0000372_irregular_coat_pigmentation1.86258075
35MP0001672_abnormal_embryogenesis/_devel1.85800290
36MP0005380_embryogenesis_phenotype1.85800290
37MP0003890_abnormal_embryonic-extraembry1.82469247
38MP0005551_abnormal_eye_electrophysiolog1.82428431
39MP0008877_abnormal_DNA_methylation1.81758345
40MP0002877_abnormal_melanocyte_morpholog1.78691361
41MP0002332_abnormal_exercise_endurance1.78440628
42MP0003984_embryonic_growth_retardation1.74741620
43MP0009278_abnormal_bone_marrow1.74463154
44MP0002088_abnormal_embryonic_growth/wei1.72496309
45MP0002086_abnormal_extraembryonic_tissu1.71528586
46MP0003122_maternal_imprinting1.71031998
47MP0003119_abnormal_digestive_system1.68652095
48MP0009046_muscle_twitch1.67475117
49MP0000427_abnormal_hair_cycle1.64683285
50MP0008961_abnormal_basal_metabolism1.59919802
51MP0003303_peritoneal_inflammation1.58820998
52MP0001502_abnormal_circadian_rhythm1.55677891
53MP0001486_abnormal_startle_reflex1.54218678
54MP0002080_prenatal_lethality1.53208491
55MP0004145_abnormal_muscle_electrophysio1.52141621
56MP0008932_abnormal_embryonic_tissue1.49267010
57MP0000569_abnormal_digit_pigmentation1.49044811
58MP0004142_abnormal_muscle_tone1.48908475
59MP0005174_abnormal_tail_pigmentation1.47856004
60MP0004885_abnormal_endolymph1.47541744
61MP0004197_abnormal_fetal_growth/weight/1.43043876
62MP0003880_abnormal_central_pattern1.40017300
63MP0002736_abnormal_nociception_after1.37348159
64MP0005646_abnormal_pituitary_gland1.36985018
65MP0009672_abnormal_birth_weight1.36956402
66MP0002063_abnormal_learning/memory/cond1.34959557
67MP0001293_anophthalmia1.34905578
68MP0004859_abnormal_synaptic_plasticity1.34578969
69MP0005257_abnormal_intraocular_pressure1.34248619
70MP0000383_abnormal_hair_follicle1.31720641
71MP0003656_abnormal_erythrocyte_physiolo1.31670562
72MP0000631_abnormal_neuroendocrine_gland1.31273959
73MP0005645_abnormal_hypothalamus_physiol1.30745067
74MP0001968_abnormal_touch/_nociception1.28873837
75MP0010234_abnormal_vibrissa_follicle1.28097027
76MP0003566_abnormal_cell_adhesion1.27478833
77MP0009745_abnormal_behavioral_response1.26935355
78MP0003283_abnormal_digestive_organ1.26556981
79MP0003137_abnormal_impulse_conducting1.26519389
80MP0003861_abnormal_nervous_system1.24679917
81MP0001915_intracranial_hemorrhage1.24026602
82MP0008007_abnormal_cellular_replicative1.22584651
83MP0005386_behavior/neurological_phenoty1.21976920
84MP0004924_abnormal_behavior1.21976920
85MP0002572_abnormal_emotion/affect_behav1.21129554
86MP0002095_abnormal_skin_pigmentation1.20832173
87MP0006276_abnormal_autonomic_nervous1.20102765
88MP0004185_abnormal_adipocyte_glucose1.19646681
89MP0004133_heterotaxia1.18805285
90MP0008770_decreased_survivor_rate1.16728012
91MP0002272_abnormal_nervous_system1.16678778
92MP0004233_abnormal_muscle_weight1.16176620
93MP0000428_abnormal_craniofacial_morphol1.15505058
94MP0005621_abnormal_cell_physiology1.14633861
95MP0001545_abnormal_hematopoietic_system1.14612670
96MP0005397_hematopoietic_system_phenotyp1.14612670
97MP0009053_abnormal_anal_canal1.14377894
98MP0002067_abnormal_sensory_capabilities1.12702791
99MP0005394_taste/olfaction_phenotype1.10762934
100MP0005499_abnormal_olfactory_system1.10762934
101MP0009703_decreased_birth_body1.10497719
102MP0002102_abnormal_ear_morphology1.10308429
103MP0002735_abnormal_chemical_nociception1.07953319
104MP0003115_abnormal_respiratory_system1.06212302
105MP0003787_abnormal_imprinting1.06152016
106MP0000537_abnormal_urethra_morphology1.05986133
107MP0005384_cellular_phenotype1.05881796
108MP0002557_abnormal_social/conspecific_i1.05372189
109MP0003091_abnormal_cell_migration1.05159997
110MP0003635_abnormal_synaptic_transmissio1.04627471
111MP0005266_abnormal_metabolism1.03340580
112MP0002925_abnormal_cardiovascular_devel1.02723295
113MP0008058_abnormal_DNA_repair1.02566491
114MP0000733_abnormal_muscle_development1.01926878
115MP0004808_abnormal_hematopoietic_stem1.01862345
116MP0004811_abnormal_neuron_physiology1.01477712
117MP0001501_abnormal_sleep_pattern1.01145543
118MP0002882_abnormal_neuron_morphology0.99826920
119MP0002177_abnormal_outer_ear0.98670336
120MP0000313_abnormal_cell_death0.98482819
121MP0002019_abnormal_tumor_incidence0.98458430
122MP0003935_abnormal_craniofacial_develop0.98280769
123MP0000490_abnormal_crypts_of0.98258297
124MP0002938_white_spotting0.98001116
125MP0002282_abnormal_trachea_morphology0.97897695
126MP0003300_gastrointestinal_ulcer0.97447812
127MP0002064_seizures0.97197038
128MP0008789_abnormal_olfactory_epithelium0.96902309
129MP0002928_abnormal_bile_duct0.96526176
130MP0002752_abnormal_somatic_nervous0.93838202
131MP0004085_abnormal_heartbeat0.93649180
132MP0005248_abnormal_Harderian_gland0.93066778
133MP0000371_diluted_coat_color0.92853659
134MP0002229_neurodegeneration0.92278125
135MP0004858_abnormal_nervous_system0.91218801
136MP0003786_premature_aging0.91040864
137MP0005377_hearing/vestibular/ear_phenot0.90124439
138MP0003878_abnormal_ear_physiology0.90124439
139MP0001929_abnormal_gametogenesis0.88389118
140MP0003950_abnormal_plasma_membrane0.86013124
141MP0000703_abnormal_thymus_morphology0.85808904
142MP0003698_abnormal_male_reproductive0.85493756
143MP0001299_abnormal_eye_distance/0.85328257
144MP0002638_abnormal_pupillary_reflex0.84335431
145MP0004484_altered_response_of0.83856995
146MP0002092_abnormal_eye_morphology0.83827659
147MP0003448_altered_tumor_morphology0.83421428
148MP0001970_abnormal_pain_threshold0.83274272
149MP0002751_abnormal_autonomic_nervous0.82792991
150MP0002396_abnormal_hematopoietic_system0.82706964
151MP0003755_abnormal_palate_morphology0.82015958
152MP0000955_abnormal_spinal_cord0.80383090
153MP0002837_dystrophic_cardiac_calcinosis0.80370037
154MP0002075_abnormal_coat/hair_pigmentati0.79777390
155MP0005023_abnormal_wound_healing0.79610985
156MP0000462_abnormal_digestive_system0.79402565
157MP0006292_abnormal_olfactory_placode0.78735209
158MP0009765_abnormal_xenobiotic_induced0.78530199
159MP0005391_vision/eye_phenotype0.77890461
160MP0004264_abnormal_extraembryonic_tissu0.76607346
161MP0000003_abnormal_adipose_tissue0.75224490
162MP0002184_abnormal_innervation0.74494948
163MP0001188_hyperpigmentation0.74423890
164MP0003172_abnormal_lysosome_physiology0.73937844
165MP0005075_abnormal_melanosome_morpholog0.72856875
166MP0000026_abnormal_inner_ear0.72505652
167MP0000653_abnormal_sex_gland0.72501006
168MP0002733_abnormal_thermal_nociception0.72277285
169MP0002210_abnormal_sex_determination0.72038913
170MP0003221_abnormal_cardiomyocyte_apopto0.71997704
171MP0003937_abnormal_limbs/digits/tail_de0.71058747
172MP0005187_abnormal_penis_morphology0.70748635
173MP0000266_abnormal_heart_morphology0.70556810
174MP0002398_abnormal_bone_marrow0.69998343
175MP0002111_abnormal_tail_morphology0.68530388
176MP0000432_abnormal_head_morphology0.66329173
177MP0003385_abnormal_body_wall0.65922103
178MP0002152_abnormal_brain_morphology0.65853395

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.02776986
2Intestinal atresia (HP:0011100)3.99583484
3Facial hemangioma (HP:0000329)3.99187642
4Ependymoma (HP:0002888)3.92825782
5True hermaphroditism (HP:0010459)3.84255758
6Molar tooth sign on MRI (HP:0002419)3.79381422
7Abnormality of midbrain morphology (HP:0002418)3.79381422
8Medial flaring of the eyebrow (HP:0010747)3.79202931
9Pancreatic fibrosis (HP:0100732)3.76798595
10Drooling (HP:0002307)3.68242289
11Pancreatic cysts (HP:0001737)3.68005202
12Febrile seizures (HP:0002373)3.67718862
13Gait imbalance (HP:0002141)3.66821324
14Nephronophthisis (HP:0000090)3.63567675
15Congenital primary aphakia (HP:0007707)3.57973148
16Nephrogenic diabetes insipidus (HP:0009806)3.55729348
17Excessive salivation (HP:0003781)3.48366782
18Abnormality of the astrocytes (HP:0100707)3.09038582
19Astrocytoma (HP:0009592)3.09038582
20Poor coordination (HP:0002370)3.05617222
21Abnormality of the renal medulla (HP:0100957)2.95882337
22Chronic hepatic failure (HP:0100626)2.95661525
23Cerebral aneurysm (HP:0004944)2.94479539
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91255293
25Short 4th metacarpal (HP:0010044)2.91255293
26Hemiparesis (HP:0001269)2.79390874
27Polyphagia (HP:0002591)2.78603675
28Absent speech (HP:0001344)2.73090345
29Genital tract atresia (HP:0001827)2.72872995
30Specific learning disability (HP:0001328)2.71592501
31Aplasia/Hypoplasia of the sternum (HP:0006714)2.69382337
32Anencephaly (HP:0002323)2.68407063
33Hip dysplasia (HP:0001385)2.66879138
34Abnormal hair whorl (HP:0010721)2.66768778
35Vaginal atresia (HP:0000148)2.66508002
36Shallow orbits (HP:0000586)2.63969325
37Short 1st metacarpal (HP:0010034)2.61678919
38Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.61678919
39Amyotrophic lateral sclerosis (HP:0007354)2.60385774
40Hyperventilation (HP:0002883)2.60292200
41Hand muscle atrophy (HP:0009130)2.60044173
42Insomnia (HP:0100785)2.59871766
43Increased density of long bones (HP:0006392)2.57696168
44Progressive cerebellar ataxia (HP:0002073)2.57447835
45Abnormality of the renal cortex (HP:0011035)2.57049486
46Hyperacusis (HP:0010780)2.52362353
47Widely spaced teeth (HP:0000687)2.51742217
48Renal cortical cysts (HP:0000803)2.50880603
49Breast hypoplasia (HP:0003187)2.49622869
50Hypoplastic pelvis (HP:0008839)2.48440966
51Protruding tongue (HP:0010808)2.48192643
52Abnormality of the lower motor neuron (HP:0002366)2.47922231
53Oculomotor apraxia (HP:0000657)2.47724470
54Heterotopia (HP:0002282)2.47211403
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.46493642
56Narrow forehead (HP:0000341)2.43116204
57Lissencephaly (HP:0001339)2.41179786
58Shawl scrotum (HP:0000049)2.40976073
59Hypoplastic iliac wings (HP:0002866)2.39721954
60Rib fusion (HP:0000902)2.38782159
61Volvulus (HP:0002580)2.38627434
62Congenital hepatic fibrosis (HP:0002612)2.34688852
63Hypochromic microcytic anemia (HP:0004840)2.33622677
64Gaze-evoked nystagmus (HP:0000640)2.33227791
65Tented upper lip vermilion (HP:0010804)2.30757317
66Increased nuchal translucency (HP:0010880)2.27153124
67Broad-based gait (HP:0002136)2.26442230
68Postaxial hand polydactyly (HP:0001162)2.25464078
69Prominent nasal bridge (HP:0000426)2.24005127
70Postaxial foot polydactyly (HP:0001830)2.24004547
71Glioma (HP:0009733)2.23016139
72Oligodactyly (HP:0012165)2.21172406
73Cystic liver disease (HP:0006706)2.20728740
74Labial hypoplasia (HP:0000066)2.19037936
75Long eyelashes (HP:0000527)2.18766997
76Cortical dysplasia (HP:0002539)2.18488537
77Distal upper limb amyotrophy (HP:0007149)2.18344127
78Upper limb amyotrophy (HP:0009129)2.18344127
79Trigonocephaly (HP:0000243)2.18032742
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.17154290
81Pachygyria (HP:0001302)2.16732257
82Genu recurvatum (HP:0002816)2.14715274
83Patellar aplasia (HP:0006443)2.14378715
84Tubulointerstitial nephritis (HP:0001970)2.12726462
85Broad foot (HP:0001769)2.11820635
86Aganglionic megacolon (HP:0002251)2.11694534
87Ankle contracture (HP:0006466)2.11475370
88Apathy (HP:0000741)2.09852357
89Abnormal biliary tract physiology (HP:0012439)2.09653308
90Bile duct proliferation (HP:0001408)2.09653308
91Renal duplication (HP:0000075)2.09289699
92Abnormality of the 1st metacarpal (HP:0010009)2.08804797
93Aplasia/Hypoplasia of the spleen (HP:0010451)2.08077165
94Genetic anticipation (HP:0003743)2.07465489
95Exotropia (HP:0000577)2.05601680
96Neoplasm of the adrenal cortex (HP:0100641)2.05023426
97Decreased testicular size (HP:0008734)2.03773697
98Birth length less than 3rd percentile (HP:0003561)2.03505179
99Prominent nose (HP:0000448)2.02094698
100Abnormality of the 4th metacarpal (HP:0010012)2.00979226
101Hypoplastic female external genitalia (HP:0012815)2.00934250
102Broad thumb (HP:0011304)2.00515996
103Thin upper lip vermilion (HP:0000219)2.00097889
104Cafe-au-lait spot (HP:0000957)2.00017886
105Atonic seizures (HP:0010819)1.97736197
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.97513516
107Aplasia/Hypoplasia of the patella (HP:0006498)1.96690331
108Diminished motivation (HP:0000745)1.95698913
109Esotropia (HP:0000565)1.94283648
110Abolished electroretinogram (ERG) (HP:0000550)1.93500368
111Sloping forehead (HP:0000340)1.92924224
112Abnormality of salivation (HP:0100755)1.92416183
113Selective tooth agenesis (HP:0001592)1.91882182
114Impulsivity (HP:0100710)1.91702700
115Astigmatism (HP:0000483)1.91473448
116Limb dystonia (HP:0002451)1.91382819
117Gastrointestinal carcinoma (HP:0002672)1.91086233
118Malignant gastrointestinal tract tumors (HP:0006749)1.91086233
119Focal motor seizures (HP:0011153)1.90440861
120Vitreoretinal degeneration (HP:0000655)1.90421802
121Bowel diverticulosis (HP:0005222)1.90108809
122Basal cell carcinoma (HP:0002671)1.90015148
123Duplicated collecting system (HP:0000081)1.89774924
124Pelvic girdle muscle weakness (HP:0003749)1.89614263
125Highly arched eyebrow (HP:0002553)1.89589793
126Abnormality of the renal collecting system (HP:0004742)1.89470205
127Spinal muscular atrophy (HP:0007269)1.89369958
128Aplasia/Hypoplasia of the lens (HP:0008063)1.89164603
129Medulloblastoma (HP:0002885)1.89078712
130Abnormality of the fingertips (HP:0001211)1.88913058
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.87580040
132Proximal placement of thumb (HP:0009623)1.86968916
133Deep palmar crease (HP:0006191)1.86511216
134Hypoplastic labia majora (HP:0000059)1.86354695
135Short phalanx of the thumb (HP:0009660)1.85820162
136High anterior hairline (HP:0009890)1.84337370
137Sandal gap (HP:0001852)1.83897748
138Optic nerve coloboma (HP:0000588)1.83760092
139Thyroid-stimulating hormone excess (HP:0002925)1.83642647
140Short foot (HP:0001773)1.83068721
141Left ventricular hypertrophy (HP:0001712)1.83015089
142Deviation of the thumb (HP:0009603)1.82157784
143Tubulointerstitial abnormality (HP:0001969)1.81860534
144Failure to thrive in infancy (HP:0001531)1.80774800
145Pointed chin (HP:0000307)1.80244956
146Gastrointestinal atresia (HP:0002589)1.79819483
147Dandy-Walker malformation (HP:0001305)1.77022495
148Overlapping toe (HP:0001845)1.76538378
149Papilledema (HP:0001085)1.76137808
150Atresia of the external auditory canal (HP:0000413)1.76123073
151Hypoplastic ischia (HP:0003175)1.75820695
152Elfin facies (HP:0004428)1.75784663
153Neoplasm of striated muscle (HP:0009728)1.75559915
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75517008
155Renal hypoplasia (HP:0000089)1.75371250
156Preaxial hand polydactyly (HP:0001177)1.74557961
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74532200
158Neoplasm of the heart (HP:0100544)1.74349912
159Broad palm (HP:0001169)1.74007853
160Visual hallucinations (HP:0002367)1.73114377
161Neoplasm of the oral cavity (HP:0100649)1.73060004
162Albinism (HP:0001022)1.72988948
163Micropenis (HP:0000054)1.72884225
164Abnormality of DNA repair (HP:0003254)1.72214516
165Retinal dysplasia (HP:0007973)1.71920604
166Hematochezia (HP:0002573)1.71708564
167Asplenia (HP:0001746)1.71690714
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70868652
169Colon cancer (HP:0003003)1.69918498
170Leiomyosarcoma (HP:0100243)1.68996539
171Uterine leiomyosarcoma (HP:0002891)1.68996539
172Autoamputation (HP:0001218)1.68524727
173Reticulocytosis (HP:0001923)1.68300060
174Agnosia (HP:0010524)1.66731145
175Broad phalanges of the hand (HP:0009768)1.65976459
176Abnormal neuron morphology (HP:0012757)1.65139071
177Abnormality of the motor neurons (HP:0002450)1.65139071
178Macroorchidism (HP:0000053)1.65111266
179Renovascular hypertension (HP:0100817)1.63723632
180Abnormality of chromosome segregation (HP:0002916)1.63416775
181Obsessive-compulsive behavior (HP:0000722)1.63336123
182Abnormality of the diencephalon (HP:0010662)1.63219503
183Degeneration of anterior horn cells (HP:0002398)1.61818894
184Abnormality of the anterior horn cell (HP:0006802)1.61818894
185Abnormality of the labia majora (HP:0012881)1.61231906
186Abnormality of the peritoneum (HP:0002585)1.60478990
187Hepatoblastoma (HP:0002884)1.59012544
188Trismus (HP:0000211)1.58883097
189Abnormality of the metopic suture (HP:0005556)1.58363202
190Hypopigmentation of the fundus (HP:0007894)1.58165431
191Papillary thyroid carcinoma (HP:0002895)1.56964734
192Cutis marmorata (HP:0000965)1.56499714
193Ectopic kidney (HP:0000086)1.55746765
194Overriding aorta (HP:0002623)1.55069152
195Megalocornea (HP:0000485)1.54771570
196Bladder neoplasm (HP:0009725)1.54555131
197Bladder carcinoma (HP:0002862)1.54555131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.23701394
2MAP3K94.10079497
3FRK3.76383418
4CDC73.29860814
5EEF2K3.27893388
6EPHA33.23829084
7TAOK32.88373849
8TRIM282.75809048
9LATS22.55395069
10TNIK2.50211813
11SCYL22.47351365
12BCR2.46792161
13SIK32.46510391
14MAP3K102.42995863
15WNK32.39477044
16NEK22.38484789
17CASK2.37062446
18ICK2.23759149
19MAPK132.23352935
20PKN22.11155126
21TRIB32.09322501
22TAOK12.07389745
23PAK32.02589436
24LATS11.98475028
25RIPK11.92736299
26NUAK11.89502015
27KSR21.86622494
28NTRK31.72673696
29TTK1.62780683
30TYRO31.55757586
31NLK1.51473904
32ALK1.48676444
33MAP2K71.48404988
34PINK11.47765188
35CAMK1G1.39200916
36NEK11.38816406
37PAK61.37465851
38WEE11.37139384
39GRK11.36849879
40BUB11.32962158
41PDGFRA1.29556224
42KSR11.28431969
43MAP3K81.23852768
44MTOR1.23071550
45EIF2AK11.22500220
46STK101.19127302
47SGK21.17903706
48CHEK21.17444888
49EPHA41.16760273
50MAP4K21.16142595
51CSNK1G11.15308873
52CSNK1A1L1.13109900
53MARK31.10534212
54AKT31.09958268
55EIF2AK31.08712076
56PLK21.05698953
57BRD41.03786350
58CDK41.03492717
59DYRK31.02100983
60CSNK1G21.02049260
61CHEK11.01946303
62ERN11.01919395
63SIK21.01419410
64MAP2K41.00766884
65PLK10.99109666
66MAP3K110.98607875
67CDK70.96994935
68ATR0.93490414
69STK38L0.93225303
70STK30.92792906
71OBSCN0.92558573
72PRKCE0.91646319
73MINK10.91093801
74CSNK1G30.90821645
75RET0.90700525
76STK160.89594811
77TESK20.88172227
78FER0.88054416
79BMX0.86854955
80ADRBK20.86288589
81MAP3K60.86221166
82PRKD30.86198884
83PRKD20.85970445
84DYRK1A0.84837548
85ARAF0.83071701
86CDK20.81445691
87ZAK0.80171763
88EPHB20.79297725
89MELK0.78808034
90CAMK1D0.78068057
91GRK60.76629448
92RPS6KB20.75950428
93SGK4940.75920538
94SGK2230.75920538
95PRKCG0.74296522
96PLK40.72589053
97RAF10.71923312
98CDK60.71112650
99ERBB30.70963723
100IRAK10.69797394
101PAK40.68643262
102NTRK20.67695333
103DAPK20.66868149
104DMPK0.66055044
105MARK20.64778545
106STK380.64434078
107MAP3K40.64211301
108MAP3K50.63667319
109PKN10.61649003
110CCNB10.60574275
111VRK10.60353623
112PAK20.59611423
113PDGFRB0.58890376
114TLK10.58829599
115PTK2B0.58600423
116DYRK20.58546252
117BRAF0.58491384
118CDK150.58354165
119MOS0.57847792
120MARK10.57800016
121MAP4K10.57283959
122KIT0.56727529
123CDK90.55915957
124AURKA0.55547023
125MKNK20.55180045
126ATM0.54930217
127CDK10.54832706
128AKT20.54358088
129CDK140.53644293
130BRSK10.53456297
131CDK180.53043451
132CDK11A0.52311208
133STK40.52033617
134PTK60.51491958
135CLK10.51263636
136RPS6KA40.51254289
137LRRK20.51082398
138PRKCZ0.51039286
139EPHA20.50456719
140PRKCH0.48922007
141FLT30.47713878
142PLK30.46839251
143AURKB0.46490695
144DDR20.46378723
145CDK50.46289306
146ADRBK10.46076466
147PRKAA10.45589964
148FES0.45532488
149CHUK0.44285085
150NTRK10.44098372
151BMPR1B0.44080644
152PIM10.43384846
153HIPK20.43185228
154PTK20.42534299
155MAPK100.42122170
156PNCK0.42114097
157UHMK10.41858067
158MAPK140.41143535
159PASK0.41043538
160GRK70.40772262
161STK110.40509631
162MAP2K60.39549201
163RPS6KA10.39509430
164BRSK20.38602461
165TTN0.38401040
166SGK30.37757025
167PAK10.37676729
168CAMK10.37568664
169TNK20.37225441
170CSNK1D0.36908988
171IRAK40.35606455
172IKBKB0.35488246
173SGK10.32945094
174INSRR0.32556925
175CDK30.31851818
176MATK0.31842731

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.10213601
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.06905033
3Steroid biosynthesis_Homo sapiens_hsa001002.90487898
4Phototransduction_Homo sapiens_hsa047442.77815911
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.46335795
6Selenocompound metabolism_Homo sapiens_hsa004502.44437525
7DNA replication_Homo sapiens_hsa030302.40300929
8Circadian rhythm_Homo sapiens_hsa047102.25378865
9Cell cycle_Homo sapiens_hsa041102.24356965
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21835848
11Collecting duct acid secretion_Homo sapiens_hsa049662.18098506
12RNA transport_Homo sapiens_hsa030132.03436023
13Butanoate metabolism_Homo sapiens_hsa006502.02860935
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00619709
15mTOR signaling pathway_Homo sapiens_hsa041501.97400938
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92012339
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90282237
18Mismatch repair_Homo sapiens_hsa034301.74404000
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73911617
20Non-homologous end-joining_Homo sapiens_hsa034501.73577731
21Nitrogen metabolism_Homo sapiens_hsa009101.72723056
22mRNA surveillance pathway_Homo sapiens_hsa030151.72131379
23Protein export_Homo sapiens_hsa030601.71314833
24Chronic myeloid leukemia_Homo sapiens_hsa052201.68359133
25Fatty acid elongation_Homo sapiens_hsa000621.66666133
26Nicotine addiction_Homo sapiens_hsa050331.65447964
27Base excision repair_Homo sapiens_hsa034101.62809057
28Oocyte meiosis_Homo sapiens_hsa041141.62745618
29Colorectal cancer_Homo sapiens_hsa052101.58885609
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58853182
31Spliceosome_Homo sapiens_hsa030401.53800242
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49973841
33MicroRNAs in cancer_Homo sapiens_hsa052061.47466836
34GABAergic synapse_Homo sapiens_hsa047271.44056777
35Basal transcription factors_Homo sapiens_hsa030221.43829961
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43627500
37Non-small cell lung cancer_Homo sapiens_hsa052231.42598470
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42597624
39Dorso-ventral axis formation_Homo sapiens_hsa043201.41244688
40Circadian entrainment_Homo sapiens_hsa047131.38843106
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36009640
42p53 signaling pathway_Homo sapiens_hsa041151.35585285
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.34208215
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32429438
45Glioma_Homo sapiens_hsa052141.30393755
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27830230
47Pancreatic cancer_Homo sapiens_hsa052121.25205255
48Renal cell carcinoma_Homo sapiens_hsa052111.24972984
49Endometrial cancer_Homo sapiens_hsa052131.24433104
50Bladder cancer_Homo sapiens_hsa052191.22170897
51Ether lipid metabolism_Homo sapiens_hsa005651.21685363
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21516413
53Olfactory transduction_Homo sapiens_hsa047401.21065140
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20428836
55Regulation of autophagy_Homo sapiens_hsa041401.19073152
56VEGF signaling pathway_Homo sapiens_hsa043701.17414771
57Long-term depression_Homo sapiens_hsa047301.16691724
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.16588094
59Morphine addiction_Homo sapiens_hsa050321.15451409
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14776261
61Hippo signaling pathway_Homo sapiens_hsa043901.12172184
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11663566
63Viral carcinogenesis_Homo sapiens_hsa052031.09293577
64Glutamatergic synapse_Homo sapiens_hsa047241.09047507
65Thyroid cancer_Homo sapiens_hsa052161.08439819
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08112547
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08103177
68Notch signaling pathway_Homo sapiens_hsa043301.07294730
69Estrogen signaling pathway_Homo sapiens_hsa049151.07055715
70RNA degradation_Homo sapiens_hsa030181.06463770
71One carbon pool by folate_Homo sapiens_hsa006701.06449273
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05631563
73Adherens junction_Homo sapiens_hsa045201.05160544
74HTLV-I infection_Homo sapiens_hsa051661.04332616
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00508410
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99765969
77Basal cell carcinoma_Homo sapiens_hsa052170.98779300
78Hepatitis B_Homo sapiens_hsa051610.97684948
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96719676
80Small cell lung cancer_Homo sapiens_hsa052220.96382988
81ErbB signaling pathway_Homo sapiens_hsa040120.94485051
82Acute myeloid leukemia_Homo sapiens_hsa052210.92191023
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90248216
84Axon guidance_Homo sapiens_hsa043600.89153757
85Gap junction_Homo sapiens_hsa045400.89076974
86Propanoate metabolism_Homo sapiens_hsa006400.88024598
87Type II diabetes mellitus_Homo sapiens_hsa049300.87904798
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87291027
89Apoptosis_Homo sapiens_hsa042100.85615236
90Hedgehog signaling pathway_Homo sapiens_hsa043400.84889975
91Epstein-Barr virus infection_Homo sapiens_hsa051690.84327382
92Proteoglycans in cancer_Homo sapiens_hsa052050.84047855
93Homologous recombination_Homo sapiens_hsa034400.83602022
94Prostate cancer_Homo sapiens_hsa052150.82630943
95HIF-1 signaling pathway_Homo sapiens_hsa040660.80999776
96Alcoholism_Homo sapiens_hsa050340.80498577
97Long-term potentiation_Homo sapiens_hsa047200.80474840
98GnRH signaling pathway_Homo sapiens_hsa049120.79939884
99Viral myocarditis_Homo sapiens_hsa054160.78168681
100Choline metabolism in cancer_Homo sapiens_hsa052310.78074594
101ABC transporters_Homo sapiens_hsa020100.77853580
102Insulin signaling pathway_Homo sapiens_hsa049100.75304870
103AMPK signaling pathway_Homo sapiens_hsa041520.75036739
104MAPK signaling pathway_Homo sapiens_hsa040100.74620327
105Pathways in cancer_Homo sapiens_hsa052000.74207118
106Fanconi anemia pathway_Homo sapiens_hsa034600.74101835
107Vibrio cholerae infection_Homo sapiens_hsa051100.73076279
108Nucleotide excision repair_Homo sapiens_hsa034200.72393976
109Herpes simplex infection_Homo sapiens_hsa051680.72381948
110Shigellosis_Homo sapiens_hsa051310.72222985
111Cocaine addiction_Homo sapiens_hsa050300.72075771
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72060535
113Systemic lupus erythematosus_Homo sapiens_hsa053220.70221471
114Prolactin signaling pathway_Homo sapiens_hsa049170.68172255
115B cell receptor signaling pathway_Homo sapiens_hsa046620.67889858
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.67444615
117Cholinergic synapse_Homo sapiens_hsa047250.65889080
118TGF-beta signaling pathway_Homo sapiens_hsa043500.65737392
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.64917061
120Wnt signaling pathway_Homo sapiens_hsa043100.64642938
121Lysine degradation_Homo sapiens_hsa003100.64424479
122Endocytosis_Homo sapiens_hsa041440.64077959
123Melanoma_Homo sapiens_hsa052180.63944087
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63940213
125Melanogenesis_Homo sapiens_hsa049160.63408007
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62083428
127Dopaminergic synapse_Homo sapiens_hsa047280.61260853
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60829359
129FoxO signaling pathway_Homo sapiens_hsa040680.60715074
130Focal adhesion_Homo sapiens_hsa045100.58753461
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58424343
132Osteoclast differentiation_Homo sapiens_hsa043800.58385300
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58320005
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56921304
135Calcium signaling pathway_Homo sapiens_hsa040200.56736299
136Insulin resistance_Homo sapiens_hsa049310.56611659
137Fatty acid metabolism_Homo sapiens_hsa012120.56414998
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55964481
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55098771
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53988347
141Rap1 signaling pathway_Homo sapiens_hsa040150.53264166
142Synaptic vesicle cycle_Homo sapiens_hsa047210.52488623
143Peroxisome_Homo sapiens_hsa041460.50597210
144Inositol phosphate metabolism_Homo sapiens_hsa005620.50341252
145Oxytocin signaling pathway_Homo sapiens_hsa049210.49958369
146Serotonergic synapse_Homo sapiens_hsa047260.49917491
147Toxoplasmosis_Homo sapiens_hsa051450.49736198
148cAMP signaling pathway_Homo sapiens_hsa040240.49295524
149Linoleic acid metabolism_Homo sapiens_hsa005910.48469204
150Influenza A_Homo sapiens_hsa051640.48094470
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46709157
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46695665
153Taste transduction_Homo sapiens_hsa047420.46500598
154Amphetamine addiction_Homo sapiens_hsa050310.44152988
155Sphingolipid metabolism_Homo sapiens_hsa006000.40984733
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.37498017
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.37363648
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35642854
159Glycerolipid metabolism_Homo sapiens_hsa005610.33277341
160Oxidative phosphorylation_Homo sapiens_hsa001900.30953353
161Legionellosis_Homo sapiens_hsa051340.30727000
162Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29691520
163Ras signaling pathway_Homo sapiens_hsa040140.29650811

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