FBXO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pseudouridine synthesis (GO:0001522)5.20356448
2proteasome assembly (GO:0043248)4.70133016
3DNA deamination (GO:0045006)4.41785184
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20458011
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.20458011
6NAD biosynthetic process (GO:0009435)4.04680458
7antigen processing and presentation of endogenous antigen (GO:0019883)3.78074661
8homocysteine metabolic process (GO:0050667)3.72501163
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71446649
10pyridine nucleotide biosynthetic process (GO:0019363)3.70184337
11nicotinamide nucleotide biosynthetic process (GO:0019359)3.70184337
12DNA catabolic process, exonucleolytic (GO:0000738)3.68383576
13positive regulation of B cell differentiation (GO:0045579)3.64536257
14bone trabecula formation (GO:0060346)3.51468198
15positive regulation of gamma-delta T cell activation (GO:0046645)3.45073816
16valine metabolic process (GO:0006573)3.38027149
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36364605
18positive regulation of histone methylation (GO:0031062)3.33963778
19protein complex biogenesis (GO:0070271)3.32574879
20positive regulation of hair follicle development (GO:0051798)3.27472114
21positive regulation of hair cycle (GO:0042635)3.27472114
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26669374
23DNA double-strand break processing (GO:0000729)3.25413724
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25036604
25response to interferon-beta (GO:0035456)3.25033816
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23493143
27ribosomal small subunit assembly (GO:0000028)3.22489247
28complement activation, alternative pathway (GO:0006957)3.19413897
29indole-containing compound catabolic process (GO:0042436)3.16401254
30indolalkylamine catabolic process (GO:0046218)3.16401254
31tryptophan catabolic process (GO:0006569)3.16401254
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13438968
33mitochondrial respiratory chain complex assembly (GO:0033108)3.11950052
34cellular response to interferon-beta (GO:0035458)3.11363600
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.10983278
36NADH dehydrogenase complex assembly (GO:0010257)3.10983278
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10983278
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10891702
39oligosaccharide catabolic process (GO:0009313)3.10259554
40negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.09364541
41aromatic amino acid family catabolic process (GO:0009074)3.08771168
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08195706
43L-fucose catabolic process (GO:0042355)3.06476105
44fucose catabolic process (GO:0019317)3.06476105
45L-fucose metabolic process (GO:0042354)3.06476105
46peptidyl-glutamic acid carboxylation (GO:0017187)3.04075110
47protein carboxylation (GO:0018214)3.04075110
48tryptophan metabolic process (GO:0006568)3.03627890
49kynurenine metabolic process (GO:0070189)3.01309508
50cell wall macromolecule catabolic process (GO:0016998)3.01105588
51low-density lipoprotein particle clearance (GO:0034383)3.00634926
52negative regulation of T cell receptor signaling pathway (GO:0050860)2.99640658
53metallo-sulfur cluster assembly (GO:0031163)2.98772986
54iron-sulfur cluster assembly (GO:0016226)2.98772986
55regulation of protein activation cascade (GO:2000257)2.96655095
56regulation of T cell receptor signaling pathway (GO:0050856)2.94424693
57purine nucleotide salvage (GO:0032261)2.93826155
58regulation of RIG-I signaling pathway (GO:0039535)2.93822381
59regulation of complement activation (GO:0030449)2.93240825
60L-phenylalanine metabolic process (GO:0006558)2.92651791
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92651791
62L-phenylalanine catabolic process (GO:0006559)2.91596643
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91596643
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.90939132
65sulfur amino acid catabolic process (GO:0000098)2.90432010
66energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88900072
67ATP synthesis coupled proton transport (GO:0015986)2.88900072
68regulation of sequestering of triglyceride (GO:0010889)2.87566447
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87347227
70growth hormone receptor signaling pathway (GO:0060396)2.85532621
71response to water (GO:0009415)2.84850825
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83898716
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83710792
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83710792
75cytochrome complex assembly (GO:0017004)2.83535916
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83035779
77base-excision repair, AP site formation (GO:0006285)2.82425794
78aldehyde catabolic process (GO:0046185)2.81841117
79actin nucleation (GO:0045010)2.81133760
80alpha-linolenic acid metabolic process (GO:0036109)2.80690149
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.78334218
82negative regulation of protein autophosphorylation (GO:0031953)2.77948044
83ribosomal large subunit biogenesis (GO:0042273)2.77555501
84pyridine-containing compound biosynthetic process (GO:0072525)2.77466647
85positive regulation of histone H3-K4 methylation (GO:0051571)2.75293823
86cell wall macromolecule metabolic process (GO:0044036)2.72421060
87positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.71740491
88deoxyribose phosphate catabolic process (GO:0046386)2.71533993
89deoxyribose phosphate biosynthetic process (GO:0046385)2.69992723
902-deoxyribonucleotide biosynthetic process (GO:0009265)2.69992723
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69889553
92positive regulation of natural killer cell differentiation (GO:0032825)2.69236617
93preassembly of GPI anchor in ER membrane (GO:0016254)2.68614419
94deoxyribonucleotide catabolic process (GO:0009264)2.67397063
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65300479
96positive regulation of cellular amide metabolic process (GO:0034250)2.64910838
97regulation of B cell differentiation (GO:0045577)2.63420020
98regulation of mitochondrial translation (GO:0070129)2.63280774
99response to lipoprotein particle (GO:0055094)2.63155678
100polyketide metabolic process (GO:0030638)2.63062476
101doxorubicin metabolic process (GO:0044598)2.63062476
102daunorubicin metabolic process (GO:0044597)2.63062476
103response to interferon-alpha (GO:0035455)2.61959351
104respiratory chain complex IV assembly (GO:0008535)2.61575583
105phospholipid efflux (GO:0033700)2.61301055
106response to parathyroid hormone (GO:0071107)2.60939455
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60554332
108plasma lipoprotein particle clearance (GO:0034381)2.59104935
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57425946
110negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.54252211
111electron transport chain (GO:0022900)2.53985302
112branched-chain amino acid catabolic process (GO:0009083)2.52902566
113amino-acid betaine metabolic process (GO:0006577)2.52716692
114cytidine deamination (GO:0009972)2.52541190
115cytidine metabolic process (GO:0046087)2.52541190
116cytidine catabolic process (GO:0006216)2.52541190
117response to type I interferon (GO:0034340)2.51273180
118positive regulation of granulocyte differentiation (GO:0030854)2.51062166
119regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.50556884
120reverse cholesterol transport (GO:0043691)2.50506309
1212-deoxyribonucleotide metabolic process (GO:0009394)2.50436262
122negative regulation of thymocyte apoptotic process (GO:0070244)2.49617561
123deoxyribose phosphate metabolic process (GO:0019692)2.49485464
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49279807
125regulation of gamma-delta T cell activation (GO:0046643)2.49052600
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48603699
127phenylpropanoid metabolic process (GO:0009698)2.48434533
128complement activation (GO:0006956)2.48278255
129regulation of triglyceride catabolic process (GO:0010896)2.47731895
130oxidative phosphorylation (GO:0006119)2.47240514
131response to interleukin-15 (GO:0070672)2.46924998
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.46881981
133isotype switching (GO:0045190)2.46881981
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.46881981
135NAD metabolic process (GO:0019674)2.46564003
136telomere maintenance via semi-conservative replication (GO:0032201)2.45804212
137cellular response to interleukin-15 (GO:0071350)2.45628898
138respiratory electron transport chain (GO:0022904)2.45532721
139negative regulation of lipid storage (GO:0010888)2.45403775
140cellular response to type I interferon (GO:0071357)2.44704530
141type I interferon signaling pathway (GO:0060337)2.44704530
142regulation of cholesterol storage (GO:0010885)2.43430515
143tRNA processing (GO:0008033)2.43224278
144DNA dealkylation (GO:0035510)2.42671020
145C-terminal protein lipidation (GO:0006501)2.42474088
146cysteine metabolic process (GO:0006534)2.42345169
147purine deoxyribonucleotide catabolic process (GO:0009155)2.42248480
148cellular response to vitamin (GO:0071295)2.42087113
149adenosine metabolic process (GO:0046085)2.41992069
150high-density lipoprotein particle remodeling (GO:0034375)2.41792176
151cellular response to vitamin D (GO:0071305)2.41006134
152negative regulation of granulocyte differentiation (GO:0030853)2.40848009
153lysine metabolic process (GO:0006553)2.40333674
154lysine catabolic process (GO:0006554)2.40333674
155positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.40272456
156cellular response to growth hormone stimulus (GO:0071378)2.39478088
157complement activation, classical pathway (GO:0006958)2.39470867
158mannosylation (GO:0097502)2.39093206
159regulation of cellular amino acid metabolic process (GO:0006521)2.39087109
160aggressive behavior (GO:0002118)2.37819420
161negative regulation of fibrinolysis (GO:0051918)2.37370756
162purine-containing compound salvage (GO:0043101)2.37051412
163regulation of B cell receptor signaling pathway (GO:0050855)2.36653471
164telomere maintenance via recombination (GO:0000722)2.36593835
165NIK/NF-kappaB signaling (GO:0038061)2.35770501
166nucleobase biosynthetic process (GO:0046112)2.35766554
167fatty acid beta-oxidation (GO:0006635)2.35211329
168protein activation cascade (GO:0072376)2.34466297
169regulation of humoral immune response (GO:0002920)2.34317887
170branched-chain amino acid metabolic process (GO:0009081)2.34296231
171mismatch repair (GO:0006298)2.34056179
172indolalkylamine metabolic process (GO:0006586)2.32148967
173urea cycle (GO:0000050)2.30762920
174urea metabolic process (GO:0019627)2.30762920
175triglyceride homeostasis (GO:0070328)2.29754596
176acylglycerol homeostasis (GO:0055090)2.29754596
177regulation of natural killer cell differentiation (GO:0032823)2.29442259
178regulation of interleukin-12 biosynthetic process (GO:0045075)2.28731690
179fatty acid oxidation (GO:0019395)2.28498019
180triglyceride catabolic process (GO:0019433)2.28435948
181fibrinolysis (GO:0042730)2.28398885
182positive regulation of lipid catabolic process (GO:0050996)2.28291473
183lipid oxidation (GO:0034440)2.26381984
184diacylglycerol metabolic process (GO:0046339)2.25721493
185superoxide anion generation (GO:0042554)2.25518910
186positive regulation of interferon-alpha production (GO:0032727)2.23872888
187regulation of extracellular matrix disassembly (GO:0010715)2.23311260
188regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.23270687
189alkaloid metabolic process (GO:0009820)2.23068845
190bile acid biosynthetic process (GO:0006699)2.22873489
191acylglycerol catabolic process (GO:0046464)2.21602947
192neutral lipid catabolic process (GO:0046461)2.21602947
193positive regulation of T cell mediated cytotoxicity (GO:0001916)2.21364245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03494923
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.84735097
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.77714976
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.30158210
5E2F7_22180533_ChIP-Seq_HELA_Human4.16979551
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.10018930
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.05524999
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.69099599
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51042582
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48958625
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.38620393
12PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38220205
13GABP_17652178_ChIP-ChIP_JURKAT_Human3.37728090
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.95132775
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.93386654
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.68796036
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59732834
18VDR_23849224_ChIP-Seq_CD4+_Human2.59701499
19IGF1R_20145208_ChIP-Seq_DFB_Human2.57007746
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52416160
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50565838
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47462599
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46721967
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44362236
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40712422
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.40310086
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29735688
28* IRF8_27001747_Chip-Seq_BMDM_Mouse2.26872899
29GATA1_22025678_ChIP-Seq_K562_Human2.24768739
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.23193389
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22910332
32* SRF_21415370_ChIP-Seq_HL-1_Mouse2.21690082
33ELK1_19687146_ChIP-ChIP_HELA_Human2.15626629
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12066697
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10738519
36ZNF274_21170338_ChIP-Seq_K562_Hela2.08651299
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07472368
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06926304
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04855088
40FOXP3_21729870_ChIP-Seq_TREG_Human2.02204960
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02147384
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00073087
43EWS_26573619_Chip-Seq_HEK293_Human1.99211774
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95825904
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94322062
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92313161
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.89065242
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87527652
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84138041
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81625893
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80436900
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79474074
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79253667
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77428254
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.75674630
56CLOCK_20551151_ChIP-Seq_293T_Human1.75563559
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73006323
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71957238
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70824188
60* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70481134
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63129698
62FUS_26573619_Chip-Seq_HEK293_Human1.61507715
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60354666
64* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60318917
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60203514
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58929336
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56046203
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.55819396
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55364423
70RUNX_20019798_ChIP-Seq_JUKART_Human1.53233128
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.51741894
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51405725
73DCP1A_22483619_ChIP-Seq_HELA_Human1.50338159
74VDR_22108803_ChIP-Seq_LS180_Human1.49552321
75MYB_26560356_Chip-Seq_TH2_Human1.48160875
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47663009
77SCL_19346495_ChIP-Seq_HPC-7_Human1.46057126
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45689316
79GATA3_26560356_Chip-Seq_TH2_Human1.45223923
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44686314
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43460981
82MAF_26560356_Chip-Seq_TH1_Human1.41086947
83MYC_18940864_ChIP-ChIP_HL60_Human1.39577557
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39252353
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.38051554
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35134401
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33895961
88TAF15_26573619_Chip-Seq_HEK293_Human1.32131407
89MYB_26560356_Chip-Seq_TH1_Human1.28699278
90AR_20517297_ChIP-Seq_VCAP_Human1.27438433
91ER_23166858_ChIP-Seq_MCF-7_Human1.25725239
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24614647
93SOX2_20726797_ChIP-Seq_SW620_Human1.22543247
94GABP_19822575_ChIP-Seq_HepG2_Human1.22538689
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22186173
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18895015
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.18895015
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16678834
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16428533
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16223831
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15981293
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15981293
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15809566
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15197243
105VDR_24787735_ChIP-Seq_THP-1_Human1.13887700
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13751280
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11518606
108* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10735013
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.10687597
110* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09464245
111MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09449836
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09415013
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09406210
114PU_27001747_Chip-Seq_BMDM_Mouse1.09187906
115VDR_24763502_ChIP-Seq_THP-1_Human1.08980005
116TP53_22573176_ChIP-Seq_HFKS_Human1.08855886
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08204419
118TTF2_22483619_ChIP-Seq_HELA_Human1.07892373
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06661490
120P300_19829295_ChIP-Seq_ESCs_Human1.06463251
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04835604
122CJUN_26792858_Chip-Seq_BT549_Human1.04599914
123* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04489198
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04383863
125ERG_20517297_ChIP-Seq_VCAP_Human1.03532658
126GATA3_27048872_Chip-Seq_THYMUS_Human1.03314257
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.02792597
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02696722
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02544174
130NANOG_19829295_ChIP-Seq_ESCs_Human1.01476417
131SOX2_19829295_ChIP-Seq_ESCs_Human1.01476417
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99488649
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98784857
134KDM5A_27292631_Chip-Seq_BREAST_Human0.98402623
135ELK3_25401928_ChIP-Seq_HUVEC_Human0.97986839
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97825380
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97141558
138E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97004039
139SPI1_23547873_ChIP-Seq_NB4_Human0.96596067
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95949244
141* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95054990
142* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94706656
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94176198
144CBP_20019798_ChIP-Seq_JUKART_Human0.93127191
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93127191
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93112840
147* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92979208
148* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92723734
149TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92709448
150* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92250202
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92186334
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92072991
153CIITA_25753668_ChIP-Seq_RAJI_Human0.91334166
154GATA4_25053715_ChIP-Seq_YYC3_Human0.91102007
155* GATA3_26560356_Chip-Seq_TH1_Human0.90986849
156HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90758016
157LXR_22292898_ChIP-Seq_THP-1_Human0.89410572
158* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88660628
159GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88550096
160* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88371393
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88335521
162UTX_26944678_Chip-Seq_JUKART_Human0.88089354
163SPI1_23127762_ChIP-Seq_K562_Human0.87751721
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87748650
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.87375725
166MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87372670
167SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87204496
168SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87204496
169PHF8_20622853_ChIP-Seq_HELA_Human0.87033809
170GATA6_21074721_ChIP-Seq_CACO-2_Human0.87004612
171FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81722572
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.81412753
173VDR_21846776_ChIP-Seq_THP-1_Human0.80191838
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79457292
175PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78894307
176SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77082628
177RUNX1_22412390_ChIP-Seq_EML_Mouse0.77026346
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.77022289
179TBX20_22080862_ChIP-Seq_HEART_Mouse0.77022289
180BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76598218
181NFE2_27457419_Chip-Seq_LIVER_Mouse0.76417904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.74690732
2MP0000569_abnormal_digit_pigmentation3.46999543
3MP0008058_abnormal_DNA_repair3.19998265
4MP0002139_abnormal_hepatobiliary_system3.18414124
5MP0003195_calcinosis3.02668880
6MP0005360_urolithiasis2.98950944
7MP0001835_abnormal_antigen_presentation2.68739682
8MP0004147_increased_porphyrin_level2.48129386
9MP0010094_abnormal_chromosome_stability2.47068252
10MP0000685_abnormal_immune_system2.39693183
11MP0003724_increased_susceptibility_to2.35503287
12MP0006036_abnormal_mitochondrial_physio2.33670899
13MP0003191_abnormal_cellular_cholesterol2.28412987
14MP0003436_decreased_susceptibility_to2.26176360
15MP0008057_abnormal_DNA_replication2.23008361
16MP0001790_abnormal_immune_system2.22586190
17MP0005387_immune_system_phenotype2.22586190
18MP0005085_abnormal_gallbladder_physiolo2.22574889
19MP0005365_abnormal_bile_salt2.21404931
20MP0009785_altered_susceptibility_to2.20680195
21MP0001545_abnormal_hematopoietic_system2.04296776
22MP0005397_hematopoietic_system_phenotyp2.04296776
23MP0003786_premature_aging2.01208158
24MP0005275_abnormal_skin_tensile2.01137953
25MP0009384_cardiac_valve_regurgitation1.98160363
26MP0003252_abnormal_bile_duct1.91959866
27MP0010329_abnormal_lipoprotein_level1.88079420
28MP0005174_abnormal_tail_pigmentation1.85100614
29MP0005670_abnormal_white_adipose1.77147197
30MP0001764_abnormal_homeostasis1.76327417
31MP0005083_abnormal_biliary_tract1.76043260
32MP0008877_abnormal_DNA_methylation1.73600233
33MP0008995_early_reproductive_senescence1.72480095
34MP0001958_emphysema1.70213390
35MP0002419_abnormal_innate_immunity1.69405223
36MP0005075_abnormal_melanosome_morpholog1.68907698
37MP0002132_abnormal_respiratory_system1.68621629
38MP0002254_reproductive_system_inflammat1.68029257
39MP0008872_abnormal_physiological_respon1.67743705
40MP0000516_abnormal_urinary_system1.67385807
41MP0005367_renal/urinary_system_phenotyp1.67385807
42MP0009764_decreased_sensitivity_to1.65132752
43MP0002933_joint_inflammation1.65107789
44MP0005671_abnormal_response_to1.64531869
45MP0005025_abnormal_response_to1.63696563
46MP0006072_abnormal_retinal_apoptosis1.62509595
47MP0003300_gastrointestinal_ulcer1.60402096
48MP0001800_abnormal_humoral_immune1.59629117
49MP0002166_altered_tumor_susceptibility1.58648133
50MP0001533_abnormal_skeleton_physiology1.56165138
51MP0009840_abnormal_foam_cell1.55517466
52MP0002452_abnormal_antigen_presenting1.54755540
53MP0005000_abnormal_immune_tolerance1.54257708
54MP0002138_abnormal_hepatobiliary_system1.54174375
55MP0001873_stomach_inflammation1.53602781
56MP0003718_maternal_effect1.51838161
57MP0005084_abnormal_gallbladder_morpholo1.49562604
58MP0002148_abnormal_hypersensitivity_rea1.47720905
59MP0002723_abnormal_immune_serum1.47573204
60MP0008469_abnormal_protein_level1.45679749
61MP0006082_CNS_inflammation1.44033162
62MP0005646_abnormal_pituitary_gland1.43694732
63MP0000372_irregular_coat_pigmentation1.43262975
64MP0005503_abnormal_tendon_morphology1.42997150
65MP0008875_abnormal_xenobiotic_pharmacok1.42645380
66MP0001853_heart_inflammation1.41790041
67MP0003705_abnormal_hypodermis_morpholog1.37334056
68MP0000015_abnormal_ear_pigmentation1.35253023
69MP0010155_abnormal_intestine_physiology1.35164751
70MP0000609_abnormal_liver_physiology1.33426451
71MP0005332_abnormal_amino_acid1.31877746
72MP0001845_abnormal_inflammatory_respons1.28370761
73MP0002722_abnormal_immune_system1.27017287
74MP0004782_abnormal_surfactant_physiolog1.26336732
75MP0002420_abnormal_adaptive_immunity1.26020427
76MP0009333_abnormal_splenocyte_physiolog1.25934216
77MP0002837_dystrophic_cardiac_calcinosis1.25004322
78MP0001819_abnormal_immune_cell1.25002084
79MP0005464_abnormal_platelet_physiology1.24880465
80MP0004130_abnormal_muscle_cell1.24220812
81MP0005410_abnormal_fertilization1.24164039
82MP0002060_abnormal_skin_morphology1.23982580
83MP0002006_tumorigenesis1.21198223
84MP0002168_other_aberrant_phenotype1.19469028
85MP0002405_respiratory_system_inflammati1.18294659
86MP0001666_abnormal_nutrient_absorption1.17550628
87MP0003091_abnormal_cell_migration1.16480945
88MP0005636_abnormal_mineral_homeostasis1.15743724
89MP0003567_abnormal_fetal_cardiomyocyte1.15295588
90MP0002095_abnormal_skin_pigmentation1.14555434
91MP0006035_abnormal_mitochondrial_morpho1.14309134
92MP0009643_abnormal_urine_homeostasis1.14241514
93MP0003303_peritoneal_inflammation1.13787106
94MP0001542_abnormal_bone_strength1.13649886
95MP0002429_abnormal_blood_cell1.12102354
96MP0002118_abnormal_lipid_homeostasis1.11582359
97MP0003186_abnormal_redox_activity1.11188063
98MP0002998_abnormal_bone_remodeling1.09876897
99MP0006054_spinal_hemorrhage1.08712274
100MP0002160_abnormal_reproductive_system1.07412297
101MP0004947_skin_inflammation1.06957742
102MP0005666_abnormal_adipose_tissue1.06292186
103MP0005645_abnormal_hypothalamus_physiol1.05478349
104MP0005023_abnormal_wound_healing1.03444803
105MP0003566_abnormal_cell_adhesion1.02585666
106MP0005379_endocrine/exocrine_gland_phen1.00883277
107MP0005319_abnormal_enzyme/_coenzyme1.00191962
108MP0005058_abnormal_lysosome_morphology0.99931282
109MP0003279_aneurysm0.99831267
110MP0005165_increased_susceptibility_to0.99719847
111MP0002136_abnormal_kidney_physiology0.99101488
112MP0002019_abnormal_tumor_incidence0.98312297
113MP0010368_abnormal_lymphatic_system0.97369287
114MP0004272_abnormal_basement_membrane0.96661921
115MP0002102_abnormal_ear_morphology0.96517436
116MP0005220_abnormal_exocrine_pancreas0.96440274
117MP0000343_altered_response_to0.95868390
118MP0000703_abnormal_thymus_morphology0.95330164
119MP0009763_increased_sensitivity_to0.94701433
120MP0003045_fibrosis0.94077394
121MP0002693_abnormal_pancreas_physiology0.93616081
122MP0005164_abnormal_response_to0.93277347
123MP0001661_extended_life_span0.91865723
124MP0008007_abnormal_cellular_replicative0.91817592
125MP0004883_abnormal_blood_vessel0.91586851
126MP0005389_reproductive_system_phenotype0.91070625
127MP0000716_abnormal_immune_system0.91038565
128MP0003075_altered_response_to0.90984561
129MP0002396_abnormal_hematopoietic_system0.90759947
130MP0003693_abnormal_embryo_hatching0.90036179
131MP0005390_skeleton_phenotype0.89839658
132MP0001905_abnormal_dopamine_level0.88629890
133MP0002876_abnormal_thyroid_physiology0.88385932
134MP0001929_abnormal_gametogenesis0.87736544
135MP0005253_abnormal_eye_physiology0.87595446
136MP0002971_abnormal_brown_adipose0.86054890
137MP0000858_altered_metastatic_potential0.85853887
138MP0005584_abnormal_enzyme/coenzyme_acti0.85728862
139MP0004510_myositis0.85606914
140MP0000490_abnormal_crypts_of0.84829479
141MP0000750_abnormal_muscle_regeneration0.84282922
142MP0004019_abnormal_vitamin_homeostasis0.83950336
143MP0000249_abnormal_blood_vessel0.83515360
144MP0009697_abnormal_copulation0.82435078
145MP0009278_abnormal_bone_marrow0.82426208
146MP0004808_abnormal_hematopoietic_stem0.82037736
147MP0000689_abnormal_spleen_morphology0.81362983
148MP0003763_abnormal_thymus_physiology0.80813636
149MP0005551_abnormal_eye_electrophysiolog0.80341431
150MP0002398_abnormal_bone_marrow0.79514708
151MP0005535_abnormal_body_temperature0.79045779
152MP0001119_abnormal_female_reproductive0.78488995
153MP0003806_abnormal_nucleotide_metabolis0.78355386
154MP0009046_muscle_twitch0.77315370
155MP0000653_abnormal_sex_gland0.75313880
156MP0008873_increased_physiological_sensi0.74748925
157MP0004957_abnormal_blastocyst_morpholog0.74644316

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55188068
2Congenital stationary night blindness (HP:0007642)3.50586061
3Myocardial infarction (HP:0001658)3.47620529
4Chromsome breakage (HP:0040012)3.42667165
5Myositis (HP:0100614)3.30923867
6Complement deficiency (HP:0004431)3.30546178
7Abnormality of midbrain morphology (HP:0002418)3.28818395
8Molar tooth sign on MRI (HP:0002419)3.28818395
9Abnormal biliary tract physiology (HP:0012439)3.26947072
10Bile duct proliferation (HP:0001408)3.26947072
11Severe combined immunodeficiency (HP:0004430)3.26938498
12Elevated erythrocyte sedimentation rate (HP:0003565)3.21748613
13Xanthomatosis (HP:0000991)3.18036818
14Reticulocytopenia (HP:0001896)3.13616448
15Pancreatic cysts (HP:0001737)3.10726189
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05003073
17Orchitis (HP:0100796)3.00426344
18Deep venous thrombosis (HP:0002625)2.99774052
19Recurrent gram-negative bacterial infections (HP:0005420)2.97789514
20Eczematoid dermatitis (HP:0000976)2.93656224
21Abnormality of pyrimidine metabolism (HP:0004353)2.92550129
22Autoimmune hemolytic anemia (HP:0001890)2.90058184
23Thyroiditis (HP:0100646)2.86677597
24Abnormality of the renal collecting system (HP:0004742)2.86160390
25Acute necrotizing encephalopathy (HP:0006965)2.86012444
26Hypoproteinemia (HP:0003075)2.84229961
27True hermaphroditism (HP:0010459)2.83340193
28Mitochondrial inheritance (HP:0001427)2.82228016
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80246638
30Abnormality of DNA repair (HP:0003254)2.76509901
31Chronic mucocutaneous candidiasis (HP:0002728)2.76490092
32Recurrent cutaneous fungal infections (HP:0011370)2.76490092
333-Methylglutaconic aciduria (HP:0003535)2.76302752
34Duplicated collecting system (HP:0000081)2.75980011
35Hepatic necrosis (HP:0002605)2.75494540
36Systemic lupus erythematosus (HP:0002725)2.75225013
37Abnormal mitochondria in muscle tissue (HP:0008316)2.75055849
38Prolonged partial thromboplastin time (HP:0003645)2.73489620
39Abnormality of the common coagulation pathway (HP:0010990)2.72699877
40Acute encephalopathy (HP:0006846)2.72496094
41Severe visual impairment (HP:0001141)2.71764292
42Abnormality of the intrinsic pathway (HP:0010989)2.70871949
43Pancreatic fibrosis (HP:0100732)2.69716494
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.68708044
45Split foot (HP:0001839)2.67230148
46Mesangial abnormality (HP:0001966)2.66529904
47Premature rupture of membranes (HP:0001788)2.66492298
48Type II lissencephaly (HP:0007260)2.66458534
49Increased CSF lactate (HP:0002490)2.66383263
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.66138691
51Hepatocellular necrosis (HP:0001404)2.64876856
52Clubbing of toes (HP:0100760)2.63217823
53Intrahepatic cholestasis (HP:0001406)2.62993165
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62628697
55Protrusio acetabuli (HP:0003179)2.61177149
56Abnormality of complement system (HP:0005339)2.60849045
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60602133
58Lipid accumulation in hepatocytes (HP:0006561)2.58147070
59Joint hemorrhage (HP:0005261)2.57223786
60Combined immunodeficiency (HP:0005387)2.55755865
61Optic neuritis (HP:0100653)2.52798617
62Retrobulbar optic neuritis (HP:0100654)2.52798617
63Abnormality of fatty-acid metabolism (HP:0004359)2.50785520
64Hydroxyprolinuria (HP:0003080)2.48677603
65Abnormality of proline metabolism (HP:0010907)2.48677603
66Progressive macrocephaly (HP:0004481)2.47364258
67Meckel diverticulum (HP:0002245)2.47055764
68Pancreatitis (HP:0001733)2.46798733
69Abnormality of the preputium (HP:0100587)2.46793294
70Increased hepatocellular lipid droplets (HP:0006565)2.45267500
71Abnormality of T cell physiology (HP:0011840)2.45231202
72Cerebral edema (HP:0002181)2.43830822
73Vacuolated lymphocytes (HP:0001922)2.43412559
74Hyperlipoproteinemia (HP:0010980)2.43036209
75Hypoalphalipoproteinemia (HP:0003233)2.42354411
76Spontaneous hematomas (HP:0007420)2.41542343
77Gingival bleeding (HP:0000225)2.41244886
78Renal cortical cysts (HP:0000803)2.40647304
79Abnormality of chromosome stability (HP:0003220)2.39265715
80Peritonitis (HP:0002586)2.38978412
81Interstitial pulmonary disease (HP:0006530)2.36835746
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35978785
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35978785
84Hypertriglyceridemia (HP:0002155)2.35515640
85Oligodactyly (hands) (HP:0001180)2.35318488
86Reduced antithrombin III activity (HP:0001976)2.33846282
87Abnormality of macrophages (HP:0004311)2.33739448
88Striae distensae (HP:0001065)2.31125577
89Recurrent abscess formation (HP:0002722)2.30469569
90Arterial thrombosis (HP:0004420)2.29871974
91Abnormality of the ileum (HP:0001549)2.29694569
92Amyloidosis (HP:0011034)2.29651626
93Broad metatarsal (HP:0001783)2.29647710
94Absent thumb (HP:0009777)2.28084949
95Hypoplasia of the thymus (HP:0000778)2.27887285
96Nephronophthisis (HP:0000090)2.27400881
97Stomatitis (HP:0010280)2.26568161
98Hematochezia (HP:0002573)2.25984184
99Aplastic anemia (HP:0001915)2.25710674
100Tetraparesis (HP:0002273)2.24461963
101Increased intramyocellular lipid droplets (HP:0012240)2.23708131
102Chronic otitis media (HP:0000389)2.21253674
103Abnormality of T cells (HP:0002843)2.21235467
104Neutropenia (HP:0001875)2.20245986
105Vertebral compression fractures (HP:0002953)2.20122835
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19022446
107Alveolar cell carcinoma (HP:0006519)2.18758715
108Glomerulonephritis (HP:0000099)2.17131281
109Recurrent fungal infections (HP:0002841)2.17015421
110Petechiae (HP:0000967)2.16714234
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.16257241
112IgG deficiency (HP:0004315)2.15130075
113Asplenia (HP:0001746)2.13682048
114Abnormality of B cell number (HP:0010975)2.12826751
115B lymphocytopenia (HP:0010976)2.12826751
116Aplasia/Hypoplasia of the spleen (HP:0010451)2.12391419
117Ectopia lentis (HP:0001083)2.12140605
118Increased serum lactate (HP:0002151)2.11524278
119Nephritis (HP:0000123)2.10336836
120Basal ganglia calcification (HP:0002135)2.09964780
121Recurrent bacterial skin infections (HP:0005406)2.09283111
122Fat malabsorption (HP:0002630)2.08898895
123Abnormality of the prostate (HP:0008775)2.08698708
124Abolished electroretinogram (ERG) (HP:0000550)2.07717177
125Myelodysplasia (HP:0002863)2.05766162
126Pulmonary embolism (HP:0002204)2.05536656
127Increased muscle lipid content (HP:0009058)2.05046033
128Epidermoid cyst (HP:0200040)2.04302263
129Abnormality of the nasal mucosa (HP:0000433)2.04259102
130Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02647282
131Dicarboxylic aciduria (HP:0003215)2.02647282
132Cardiovascular calcification (HP:0011915)2.01888902
133Abnormality of the heme biosynthetic pathway (HP:0010472)2.01249932
134Polycythemia (HP:0001901)2.01058039
135Constricted visual fields (HP:0001133)2.00807296
136Meningitis (HP:0001287)2.00783136
137Panhypogammaglobulinemia (HP:0003139)1.99609793
138Autoimmune thrombocytopenia (HP:0001973)1.99356097
139Epistaxis (HP:0000421)1.98682496
140Vascular calcification (HP:0004934)1.98660597
141Hypoglycemic coma (HP:0001325)1.98064462
142Recurrent viral infections (HP:0004429)1.98057089
143Pancytopenia (HP:0001876)1.97879824
144Hypolipoproteinemia (HP:0010981)1.97820436
145Lactic acidosis (HP:0003128)1.97721953
146Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96945162
147Esophageal varix (HP:0002040)1.96670773
148Thrombophlebitis (HP:0004418)1.96395083
149Granulocytopenia (HP:0001913)1.94900551
150Type I transferrin isoform profile (HP:0003642)1.94872890
151Hypercholesterolemia (HP:0003124)1.94824113
152Mucopolysacchariduria (HP:0008155)1.94769723
153Urinary glycosaminoglycan excretion (HP:0003541)1.94769723
154Abnormality of purine metabolism (HP:0004352)1.93681061
155Menorrhagia (HP:0000132)1.93644409
156Mitral stenosis (HP:0001718)1.93400532
157Recurrent skin infections (HP:0001581)1.93068474
158Renal Fanconi syndrome (HP:0001994)1.92124636
159Aortic dissection (HP:0002647)1.91215520
160Abnormal rod and cone electroretinograms (HP:0008323)1.91142453
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91011721
162Abnormal protein N-linked glycosylation (HP:0012347)1.91011721
163Abnormal protein glycosylation (HP:0012346)1.91011721
164Abnormal glycosylation (HP:0012345)1.91011721
165Abnormality of alanine metabolism (HP:0010916)1.90759859
166Hyperalaninemia (HP:0003348)1.90759859
167Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90759859
168Vasculitis (HP:0002633)1.90522350
169Severe Myopia (HP:0011003)1.90449455
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90332595
171Eosinophilia (HP:0001880)1.90079824
172Generalized aminoaciduria (HP:0002909)1.89738802
173Small intestinal stenosis (HP:0012848)1.89005815
174Duodenal stenosis (HP:0100867)1.89005815
175Recurrent bronchitis (HP:0002837)1.87965012
176Attenuation of retinal blood vessels (HP:0007843)1.87392407
177Bifid tongue (HP:0010297)1.87060746
178Cervical subluxation (HP:0003308)1.86852351
179Steatorrhea (HP:0002570)1.86803743
180Abnormality of the renal cortex (HP:0011035)1.86510148
181T lymphocytopenia (HP:0005403)1.83963832
182Atrophic scars (HP:0001075)1.82777255
183Gastrointestinal inflammation (HP:0004386)1.82695342
184Skin nodule (HP:0200036)1.82656746
185Aortic aneurysm (HP:0004942)1.82602325
186Agammaglobulinemia (HP:0004432)1.81473846
187Prolonged bleeding time (HP:0003010)1.80306136
188Pendular nystagmus (HP:0012043)1.80061988
189Hyperammonemia (HP:0001987)1.78301807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.41399111
2SCYL23.01526918
3PIM22.87989552
4ADRBK22.86786358
5SIK12.75040030
6TBK12.71271607
7TGFBR22.56410757
8TRIB32.35678922
9JAK32.34861716
10VRK22.34286451
11MAP3K142.34139196
12MAP4K12.29510403
13IKBKE2.26582936
14CDK192.21970039
15FGFR42.20319037
16EIF2AK32.17858618
17ZAP702.17486946
18BLK2.09590991
19TYK22.02659880
20JAK12.00903920
21BCKDK2.00389233
22VRK11.97200885
23ZAK1.94993808
24MAP4K21.91094395
25FLT31.90618076
26MAP2K31.84424891
27STK161.79831451
28BMPR21.79609245
29OXSR11.78846231
30CSF1R1.78647805
31MAP3K31.77680866
32STK391.74251859
33MAP3K121.71656938
34KIT1.68928050
35NME21.64083370
36KDR1.61831801
37EIF2AK11.61180666
38IRAK11.59840076
39TESK21.56874347
40MST41.53435719
41IRAK31.52582168
42TAOK31.51013890
43BMPR1B1.50713361
44TLK11.47893455
45TNK21.45783313
46IKBKB1.41074249
47CSK1.40579470
48NLK1.39773322
49PKN21.39697486
50SRPK11.38745664
51EPHB11.36042658
52WNK41.35538834
53MAP3K111.32712875
54EPHA31.30369200
55IRAK41.27564492
56LRRK21.20271433
57BUB11.19561828
58RPS6KA41.19141036
59NEK91.19119333
60TEC1.15649402
61ERBB31.11005980
62MUSK1.10024576
63FRK1.09304284
64BTK1.08994472
65TAOK21.06310498
66CCNB11.05990390
67PLK41.04929591
68MST1R1.04749263
69EIF2AK21.04320713
70MAP3K131.02890842
71PTK61.01194574
72BMX1.00240867
73CDK80.95017772
74PBK0.91373759
75RIPK10.91005880
76PIK3CG0.90903298
77SIK30.90761996
78NEK10.89953346
79SYK0.89152159
80TXK0.87694630
81ARAF0.85935793
82LCK0.85862487
83TGFBR10.84333565
84CSNK1G30.82946078
85JAK20.82334785
86TTN0.82150395
87DAPK10.81941153
88ITK0.81931130
89CHUK0.81730335
90RPS6KB20.81355878
91SIK20.80134037
92MKNK10.78385594
93STK100.77311530
94TIE10.77114986
95MAPKAPK30.76735537
96PLK30.76279459
97CDK30.75593449
98FGFR30.74830597
99PIM10.74745042
100CDC70.73718772
101CAMK1D0.73643492
102ATR0.72881705
103TESK10.70794915
104TNIK0.70719160
105LYN0.69214457
106TRPM70.68126640
107INSRR0.67445611
108ADRBK10.67362136
109HCK0.65835712
110PTK2B0.65530345
111PDGFRB0.65429440
112FES0.65406000
113PRKCQ0.62339155
114WNK30.62031485
115RPS6KA50.61776455
116PRKAA20.60650996
117MAP3K100.60203361
118CSNK1G10.59659066
119PIK3CA0.58866026
120MAP3K10.57586821
121CSNK1G20.56424073
122CHEK20.55881619
123PTK20.55377173
124MAPKAPK50.55273517
125GRK10.54894861
126PRKCH0.52989867
127PRKG20.52802120
128CSNK1A1L0.52015973
129RAF10.51957557
130PLK10.51843877
131BRSK20.51059341
132FER0.50791357
133ATM0.50060424
134EGFR0.49891692
135IGF1R0.49744922
136MAPK110.48460176
137CAMKK20.48254333
138ABL10.48131635
139INSR0.47991351
140ABL20.47517833
141DYRK1B0.46865354
142CSNK2A20.46609726
143RPS6KB10.46462301
144PASK0.46144425
145NUAK10.45902844
146WEE10.45543939
147GRK60.44307105
148ACVR1B0.43347771
149MET0.43231257
150MAP2K60.42788400
151CSNK2A10.42514074
152RIPK40.41581486
153PDK20.41237190
154PRKCE0.39998852
155EPHA20.39964635
156MAPK130.39064835
157PHKG20.39057087
158MARK30.38402531
159MAPK150.38211347
160PRKCD0.37979555
161MOS0.37556481
162MAP3K70.37400597

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.97930776
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.67801545
3Asthma_Homo sapiens_hsa053102.62495526
4DNA replication_Homo sapiens_hsa030302.59532405
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53559922
6Fatty acid degradation_Homo sapiens_hsa000712.52368632
7Complement and coagulation cascades_Homo sapiens_hsa046102.38633632
8Mismatch repair_Homo sapiens_hsa034302.36549732
9Homologous recombination_Homo sapiens_hsa034402.36074958
10Staphylococcus aureus infection_Homo sapiens_hsa051502.33914433
11Non-homologous end-joining_Homo sapiens_hsa034502.29239392
12Oxidative phosphorylation_Homo sapiens_hsa001902.28735691
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.26881298
14Fanconi anemia pathway_Homo sapiens_hsa034602.26225968
15Tryptophan metabolism_Homo sapiens_hsa003802.21217275
16Graft-versus-host disease_Homo sapiens_hsa053322.13931740
17Ribosome_Homo sapiens_hsa030102.11687933
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00896624
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99455019
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96417504
21Base excision repair_Homo sapiens_hsa034101.94171049
22Parkinsons disease_Homo sapiens_hsa050121.88382014
23PPAR signaling pathway_Homo sapiens_hsa033201.86716156
24Caffeine metabolism_Homo sapiens_hsa002321.74733271
25Type I diabetes mellitus_Homo sapiens_hsa049401.72695080
26Propanoate metabolism_Homo sapiens_hsa006401.63844989
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.63246151
28Fatty acid metabolism_Homo sapiens_hsa012121.61940740
29Peroxisome_Homo sapiens_hsa041461.61281363
30Histidine metabolism_Homo sapiens_hsa003401.61138741
31Nucleotide excision repair_Homo sapiens_hsa034201.59380406
32One carbon pool by folate_Homo sapiens_hsa006701.56485669
33beta-Alanine metabolism_Homo sapiens_hsa004101.55706723
34Arginine biosynthesis_Homo sapiens_hsa002201.55470902
35Primary immunodeficiency_Homo sapiens_hsa053401.54709597
36RNA degradation_Homo sapiens_hsa030181.53329570
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51385480
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51091979
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45915906
40Sulfur metabolism_Homo sapiens_hsa009201.44416480
41Leishmaniasis_Homo sapiens_hsa051401.41592442
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.41265179
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40198750
44RNA polymerase_Homo sapiens_hsa030201.38481731
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32660819
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29762544
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28416643
48ABC transporters_Homo sapiens_hsa020101.25738159
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.23043861
50Fatty acid biosynthesis_Homo sapiens_hsa000611.22789047
51Nitrogen metabolism_Homo sapiens_hsa009101.21288148
52Malaria_Homo sapiens_hsa051441.21157456
53Pyrimidine metabolism_Homo sapiens_hsa002401.20185339
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.18365716
55Retinol metabolism_Homo sapiens_hsa008301.17498984
56Sulfur relay system_Homo sapiens_hsa041221.16821544
57Phototransduction_Homo sapiens_hsa047441.16545277
58Osteoclast differentiation_Homo sapiens_hsa043801.15223750
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14555065
60Butanoate metabolism_Homo sapiens_hsa006501.14199879
61Huntingtons disease_Homo sapiens_hsa050161.13487001
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13291548
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11272513
64Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10758060
65TNF signaling pathway_Homo sapiens_hsa046681.10222000
66Starch and sucrose metabolism_Homo sapiens_hsa005001.08858000
67Alzheimers disease_Homo sapiens_hsa050101.08343353
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07670667
69Measles_Homo sapiens_hsa051621.07470150
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06547417
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04513046
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04271968
73B cell receptor signaling pathway_Homo sapiens_hsa046621.02593114
74Spliceosome_Homo sapiens_hsa030401.02294647
75Adipocytokine signaling pathway_Homo sapiens_hsa049201.01334731
76RNA transport_Homo sapiens_hsa030131.01331673
77Chemical carcinogenesis_Homo sapiens_hsa052041.01185787
78Hematopoietic cell lineage_Homo sapiens_hsa046400.98278346
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97370690
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96885281
81Pertussis_Homo sapiens_hsa051330.96572903
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96383678
83Rheumatoid arthritis_Homo sapiens_hsa053230.95469533
84Basal transcription factors_Homo sapiens_hsa030220.91794601
85Lysosome_Homo sapiens_hsa041420.91404341
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.90742044
87Phenylalanine metabolism_Homo sapiens_hsa003600.90109000
88Purine metabolism_Homo sapiens_hsa002300.88711862
89ECM-receptor interaction_Homo sapiens_hsa045120.88516480
90Arachidonic acid metabolism_Homo sapiens_hsa005900.87900355
91Linoleic acid metabolism_Homo sapiens_hsa005910.87725156
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85887160
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85799992
94Folate biosynthesis_Homo sapiens_hsa007900.83806137
95Systemic lupus erythematosus_Homo sapiens_hsa053220.82758057
96Allograft rejection_Homo sapiens_hsa053300.81601151
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81539241
98Collecting duct acid secretion_Homo sapiens_hsa049660.80659685
99Toxoplasmosis_Homo sapiens_hsa051450.79382354
100Glutathione metabolism_Homo sapiens_hsa004800.78698632
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.78363031
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.77765936
103Other glycan degradation_Homo sapiens_hsa005110.77423648
104Selenocompound metabolism_Homo sapiens_hsa004500.76480767
105Hepatitis C_Homo sapiens_hsa051600.73299788
106Arginine and proline metabolism_Homo sapiens_hsa003300.73177057
107Fat digestion and absorption_Homo sapiens_hsa049750.73003701
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69250392
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69249562
110Pyruvate metabolism_Homo sapiens_hsa006200.69235275
111Acute myeloid leukemia_Homo sapiens_hsa052210.68329653
112Fatty acid elongation_Homo sapiens_hsa000620.67986229
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.66697092
114Olfactory transduction_Homo sapiens_hsa047400.66656072
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65351685
116Herpes simplex infection_Homo sapiens_hsa051680.64803512
117Glycerolipid metabolism_Homo sapiens_hsa005610.64741837
118Legionellosis_Homo sapiens_hsa051340.64014546
119Small cell lung cancer_Homo sapiens_hsa052220.63552260
120Metabolic pathways_Homo sapiens_hsa011000.61732445
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61449915
122Shigellosis_Homo sapiens_hsa051310.59205660
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58545425
124Apoptosis_Homo sapiens_hsa042100.57242421
125Bile secretion_Homo sapiens_hsa049760.56846849
126Vitamin digestion and absorption_Homo sapiens_hsa049770.56788685
127Amoebiasis_Homo sapiens_hsa051460.56570368
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56400880
129Pentose phosphate pathway_Homo sapiens_hsa000300.54599926
130Protein digestion and absorption_Homo sapiens_hsa049740.54365584
131Tyrosine metabolism_Homo sapiens_hsa003500.53359075
132Tuberculosis_Homo sapiens_hsa051520.52808628
133Insulin resistance_Homo sapiens_hsa049310.51602702
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51100641
135Ether lipid metabolism_Homo sapiens_hsa005650.50969712
136Phagosome_Homo sapiens_hsa041450.50025888
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49953095
138Autoimmune thyroid disease_Homo sapiens_hsa053200.49531714
139Protein export_Homo sapiens_hsa030600.47649858
140Viral myocarditis_Homo sapiens_hsa054160.47133995
141Proteoglycans in cancer_Homo sapiens_hsa052050.44543394
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.44407732
143Antigen processing and presentation_Homo sapiens_hsa046120.44283752
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43555637
145Bladder cancer_Homo sapiens_hsa052190.43119103
146Focal adhesion_Homo sapiens_hsa045100.43012435
147Regulation of autophagy_Homo sapiens_hsa041400.42925086
148Platelet activation_Homo sapiens_hsa046110.42888450
149Cell cycle_Homo sapiens_hsa041100.30047280

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