FBXO36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.53395703
2central nervous system myelination (GO:0022010)8.53395703
3cilium or flagellum-dependent cell motility (GO:0001539)7.89103663
4fusion of sperm to egg plasma membrane (GO:0007342)7.46032220
5axonemal dynein complex assembly (GO:0070286)7.05086412
6multicellular organism reproduction (GO:0032504)6.60089986
7sperm motility (GO:0030317)6.25707895
8acrosome reaction (GO:0007340)6.20560726
9fatty acid elongation (GO:0030497)6.14213201
10epithelial cilium movement (GO:0003351)6.11287564
11cilium movement (GO:0003341)5.86730552
12sperm-egg recognition (GO:0035036)5.67706769
13acrosome assembly (GO:0001675)5.62755989
14cell wall macromolecule catabolic process (GO:0016998)5.57856830
15cell wall macromolecule metabolic process (GO:0044036)5.57856830
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.47860246
17plasma membrane fusion (GO:0045026)5.42870791
18reproduction (GO:0000003)5.22756338
19sperm capacitation (GO:0048240)5.14838756
20motile cilium assembly (GO:0044458)5.12971056
21regulation of cilium movement (GO:0003352)4.97446315
22cell-cell recognition (GO:0009988)4.92005665
23binding of sperm to zona pellucida (GO:0007339)4.77603595
24single fertilization (GO:0007338)4.67930174
25piRNA metabolic process (GO:0034587)4.66914048
26spermatid development (GO:0007286)4.56472653
27male meiosis (GO:0007140)4.47701217
28behavioral response to nicotine (GO:0035095)4.17109588
29response to pheromone (GO:0019236)4.16639587
30response to methylmercury (GO:0051597)4.14413526
31myelin maintenance (GO:0043217)4.11222548
32cholesterol biosynthetic process (GO:0006695)4.08584674
33microtubule severing (GO:0051013)4.03222300
34myelination (GO:0042552)3.97643042
35ensheathment of neurons (GO:0007272)3.95324098
36axon ensheathment (GO:0008366)3.95324098
37fertilization (GO:0009566)3.89458143
38synaptonemal complex organization (GO:0070193)3.84723603
39L-phenylalanine catabolic process (GO:0006559)3.83957870
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83957870
41protein polyglutamylation (GO:0018095)3.79185012
42L-fucose catabolic process (GO:0042355)3.72757842
43fucose catabolic process (GO:0019317)3.72757842
44L-fucose metabolic process (GO:0042354)3.72757842
45photoreceptor cell differentiation (GO:0046530)3.67765910
46eye photoreceptor cell differentiation (GO:0001754)3.67765910
47organic cation transport (GO:0015695)3.67507176
48sterol biosynthetic process (GO:0016126)3.64766289
49platelet dense granule organization (GO:0060155)3.62738130
50long-chain fatty acid biosynthetic process (GO:0042759)3.60913685
51synaptonemal complex assembly (GO:0007130)3.59824274
52respiratory chain complex IV assembly (GO:0008535)3.53998917
53intraciliary transport (GO:0042073)3.46544718
54axoneme assembly (GO:0035082)3.46329848
55negative regulation of inclusion body assembly (GO:0090084)3.44768121
56negative regulation of telomere maintenance (GO:0032205)3.41214038
57nonmotile primary cilium assembly (GO:0035058)3.41074487
58cilium assembly (GO:0042384)3.40218829
59male meiosis I (GO:0007141)3.37955228
60ventricular system development (GO:0021591)3.35541922
61regulation of microtubule-based movement (GO:0060632)3.32091372
62microtubule polymerization or depolymerization (GO:0031109)3.29929890
63response to redox state (GO:0051775)3.29286859
64long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.28437468
65isoprenoid biosynthetic process (GO:0008299)3.25788700
66L-phenylalanine metabolic process (GO:0006558)3.25092201
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25092201
68water-soluble vitamin biosynthetic process (GO:0042364)3.20460871
69oligodendrocyte differentiation (GO:0048709)3.19780429
70cilium morphogenesis (GO:0060271)3.18010173
71glutathione derivative biosynthetic process (GO:1901687)3.16618851
72glutathione derivative metabolic process (GO:1901685)3.16618851
73spermatogenesis (GO:0007283)3.14904054
74presynaptic membrane assembly (GO:0097105)3.14750066
75DNA methylation involved in gamete generation (GO:0043046)3.13181622
76male gamete generation (GO:0048232)3.13144964
77protein neddylation (GO:0045116)3.09902633
78glycerophospholipid catabolic process (GO:0046475)3.08021580
79regulation of glucokinase activity (GO:0033131)3.07791623
80regulation of hexokinase activity (GO:1903299)3.07791623
81spermatid nucleus differentiation (GO:0007289)3.03845115
82cellular ketone body metabolic process (GO:0046950)3.03640362
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00371302
84heme transport (GO:0015886)2.96459688
85cytochrome complex assembly (GO:0017004)2.96388308
86fatty-acyl-CoA biosynthetic process (GO:0046949)2.95781159
87gamete generation (GO:0007276)2.95412544
88protein complex biogenesis (GO:0070271)2.93842113
89regulation of response to osmotic stress (GO:0047484)2.93722790
90protein K11-linked deubiquitination (GO:0035871)2.91855778
91long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.90586902
92preassembly of GPI anchor in ER membrane (GO:0016254)2.89618067
93negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88767912
94kidney morphogenesis (GO:0060993)2.87726482
95very long-chain fatty acid metabolic process (GO:0000038)2.87649736
96regulation of inclusion body assembly (GO:0090083)2.86779238
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.81026331
98photoreceptor cell maintenance (GO:0045494)2.80214355
99meiosis I (GO:0007127)2.79806764
100nucleoside diphosphate phosphorylation (GO:0006165)2.79662684
101calcium ion-dependent exocytosis (GO:0017156)2.78796550
102positive regulation of cellular amine metabolic process (GO:0033240)2.78205583
103nucleotide transmembrane transport (GO:1901679)2.78142019
104DNA double-strand break processing (GO:0000729)2.77258008
105negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.76954343
106regulation of collateral sprouting (GO:0048670)2.75586057
107retinal cone cell development (GO:0046549)2.74559672
108GPI anchor biosynthetic process (GO:0006506)2.72639087
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.71006834
110NADH dehydrogenase complex assembly (GO:0010257)2.71006834
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71006834
112GTP biosynthetic process (GO:0006183)2.70747494
113fatty-acyl-CoA metabolic process (GO:0035337)2.70612263
114presynaptic membrane organization (GO:0097090)2.69728820
115centriole assembly (GO:0098534)2.69059033
116ketone body metabolic process (GO:1902224)2.68962833
117glutathione metabolic process (GO:0006749)2.68933996
118protein-cofactor linkage (GO:0018065)2.67066710
119nonribosomal peptide biosynthetic process (GO:0019184)2.67017043
120cellular component assembly involved in morphogenesis (GO:0010927)2.66501373
121mitochondrial respiratory chain complex assembly (GO:0033108)2.66244356
122neural tube formation (GO:0001841)2.65881010
123mannosylation (GO:0097502)2.65441794
124negative regulation of JUN kinase activity (GO:0043508)2.62449237
125detection of light stimulus involved in sensory perception (GO:0050962)2.61077717
126detection of light stimulus involved in visual perception (GO:0050908)2.61077717
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59976014
128regulation of neurotransmitter uptake (GO:0051580)2.59913683
129centriole replication (GO:0007099)2.59226910
130cornea development in camera-type eye (GO:0061303)2.58833289
131negative regulation of protein localization to cell surface (GO:2000009)2.58427521
132regulation of telomere maintenance (GO:0032204)2.55880114
133cilium organization (GO:0044782)2.55666792
134lactate metabolic process (GO:0006089)2.55567323
135glutathione biosynthetic process (GO:0006750)2.55485865
136regulation of lipoprotein metabolic process (GO:0050746)2.54216433
137protein localization to cilium (GO:0061512)2.53111583
138somite rostral/caudal axis specification (GO:0032525)2.52616633
139amyloid precursor protein metabolic process (GO:0042982)2.52447367
140GPI anchor metabolic process (GO:0006505)2.51874534
141protein palmitoylation (GO:0018345)2.51470912
142gamma-aminobutyric acid transport (GO:0015812)2.50301157
143regulation of action potential (GO:0098900)2.49925351
144resolution of meiotic recombination intermediates (GO:0000712)2.48361321
145kynurenine metabolic process (GO:0070189)2.48303318
146ubiquinone metabolic process (GO:0006743)2.48301093
147smoothened signaling pathway (GO:0007224)2.48151860
148pyrimidine nucleobase catabolic process (GO:0006208)2.48076208
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45102080
150cullin deneddylation (GO:0010388)2.45063039
151reciprocal DNA recombination (GO:0035825)2.43601534
152reciprocal meiotic recombination (GO:0007131)2.43601534
153negative regulation of translation, ncRNA-mediated (GO:0040033)2.43488197
154regulation of translation, ncRNA-mediated (GO:0045974)2.43488197
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43488197
156negative regulation of DNA-dependent DNA replication (GO:2000104)2.43245781
157behavioral response to ethanol (GO:0048149)2.41776596
158neuronal action potential (GO:0019228)2.41316264
159photoreceptor cell development (GO:0042461)2.41297734
160inositol phosphate catabolic process (GO:0071545)2.40284991
161ATP synthesis coupled proton transport (GO:0015986)2.38926552
162energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38926552
163aldehyde catabolic process (GO:0046185)2.38743807
164ubiquinone biosynthetic process (GO:0006744)2.38015731
165reflex (GO:0060004)2.37520487
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36701024
167postsynaptic membrane organization (GO:0001941)2.35788133
168determination of left/right symmetry (GO:0007368)2.34458157
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34039370
170tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34039370
171establishment of protein localization to mitochondrial membrane (GO:0090151)2.33210558
172nephron tubule morphogenesis (GO:0072078)2.32495522
173nephron epithelium morphogenesis (GO:0072088)2.32495522
174regulation of nuclear cell cycle DNA replication (GO:0033262)2.32372608
175microtubule bundle formation (GO:0001578)2.32251044
176nucleobase catabolic process (GO:0046113)2.30134098
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.29232000
178glycosphingolipid biosynthetic process (GO:0006688)2.28324170
179C-terminal protein amino acid modification (GO:0018410)2.27091272
180regulation of mesoderm development (GO:2000380)2.25725591
181C-terminal protein lipidation (GO:0006501)2.24926377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.33622377
2ZNF274_21170338_ChIP-Seq_K562_Hela3.70545545
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66352055
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09257728
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98802546
6IGF1R_20145208_ChIP-Seq_DFB_Human2.33093768
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27426133
8* SALL1_21062744_ChIP-ChIP_HESCs_Human2.25395896
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17628787
10EWS_26573619_Chip-Seq_HEK293_Human2.15634871
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14995407
12P300_19829295_ChIP-Seq_ESCs_Human2.14657641
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06724072
14TAF15_26573619_Chip-Seq_HEK293_Human2.06292940
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02065533
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96924356
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.95646422
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93450701
19* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92150858
20RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.88543585
21VDR_22108803_ChIP-Seq_LS180_Human1.87047374
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85977987
23KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81389360
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79446251
25* FLI1_27457419_Chip-Seq_LIVER_Mouse1.76265481
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74148725
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.70559921
28BCAT_22108803_ChIP-Seq_LS180_Human1.70293994
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.68060482
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.65816439
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64990870
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60125029
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59200200
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.56740271
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56273814
36SMAD4_21799915_ChIP-Seq_A2780_Human1.55493544
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.54295385
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52468315
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51310864
40ER_23166858_ChIP-Seq_MCF-7_Human1.50436409
41* ELK1_19687146_ChIP-ChIP_HELA_Human1.49978080
42AR_25329375_ChIP-Seq_VCAP_Human1.49933946
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48531101
44MYC_18940864_ChIP-ChIP_HL60_Human1.48420508
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.47367227
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46920114
47CBP_20019798_ChIP-Seq_JUKART_Human1.46807776
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46807776
49* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45558886
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44792481
51STAT3_23295773_ChIP-Seq_U87_Human1.44484690
52TP53_22573176_ChIP-Seq_HFKS_Human1.44018936
53* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43285387
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42101439
55TCF4_22108803_ChIP-Seq_LS180_Human1.41042098
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40343639
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39251584
58* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38685621
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37985198
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37375479
61GBX2_23144817_ChIP-Seq_PC3_Human1.37255070
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35550538
63* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34761425
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34742249
65* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33994226
66IRF1_19129219_ChIP-ChIP_H3396_Human1.33915371
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32769541
68* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32326716
69* P300_18555785_Chip-Seq_ESCs_Mouse1.32288663
70* CMYC_18555785_Chip-Seq_ESCs_Mouse1.31430592
71* KLF4_18555785_Chip-Seq_ESCs_Mouse1.29544221
72* CRX_20693478_ChIP-Seq_RETINA_Mouse1.29306973
73TCF4_23295773_ChIP-Seq_U87_Human1.28963312
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28440636
75* EZH2_27294783_Chip-Seq_NPCs_Mouse1.28433409
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.28077993
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28033989
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27828293
79* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27786213
80RNF2_27304074_Chip-Seq_NSC_Mouse1.25942796
81* STAT3_18555785_Chip-Seq_ESCs_Mouse1.25140488
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.24249668
83* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24163103
84* FOXA1_25329375_ChIP-Seq_VCAP_Human1.24163103
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23154059
86* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23145223
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21953768
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21531919
89* STAT1_17558387_ChIP-Seq_HELA_Human1.20950307
90* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20185331
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18858217
92KDM2B_26808549_Chip-Seq_REH_Human1.18566179
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17835971
94EZH2_22144423_ChIP-Seq_EOC_Human1.17339536
95* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16994658
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16762855
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.15798436
98AR_20517297_ChIP-Seq_VCAP_Human1.15566602
99* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15265476
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15157493
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.15048749
102* P53_22387025_ChIP-Seq_ESCs_Mouse1.14722027
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14651482
104NCOR_22424771_ChIP-Seq_293T_Human1.13783714
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13745168
106NANOG_20526341_ChIP-Seq_ESCs_Human1.13409503
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11731337
108HTT_18923047_ChIP-ChIP_STHdh_Human1.11565685
109REST_21632747_ChIP-Seq_MESCs_Mouse1.11422684
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.11363520
111* SOX2_18555785_Chip-Seq_ESCs_Mouse1.10822597
112CDX2_22108803_ChIP-Seq_LS180_Human1.10366448
113SOX2_19829295_ChIP-Seq_ESCs_Human1.09853207
114NANOG_19829295_ChIP-Seq_ESCs_Human1.09853207
115* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08936582
116* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08936582
117PHF8_20622853_ChIP-Seq_HELA_Human1.08301995
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04412015
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04258970
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04183473
121* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03426558
122VDR_23849224_ChIP-Seq_CD4+_Human1.03420297
123SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02796804
124LXR_22158963_ChIP-Seq_LIVER_Mouse1.01542975
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01431075
126* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01323986
127ERG_20517297_ChIP-Seq_VCAP_Human1.00982661
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.00330667
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99988914
130* CTCF_18555785_Chip-Seq_ESCs_Mouse0.99985488
131* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99617267
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98709627
133HOXB7_26014856_ChIP-Seq_BT474_Human0.97953454
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97828174
135* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97227935
136* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96724875
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96582342
138* P53_21459846_ChIP-Seq_SAOS-2_Human0.96452218
139CBP_21632823_ChIP-Seq_H3396_Human0.96410542
140* NMYC_18555785_Chip-Seq_ESCs_Mouse0.96086534
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96031124
142SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95784618
143OCT4_20526341_ChIP-Seq_ESCs_Human0.95671899
144GATA3_21867929_ChIP-Seq_CD8_Mouse0.95466547
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95217582
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95207456
147TBL1_22424771_ChIP-Seq_293T_Human0.94846971
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94116798
149* ESET_19884257_ChIP-Seq_ESCs_Mouse0.92466773
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91907655
151FUS_26573619_Chip-Seq_HEK293_Human0.91657115
152* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91546651
153GF1_26923725_Chip-Seq_HPCs_Mouse0.90681375
154* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90613600
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90386005
156NFYB_21822215_ChIP-Seq_K562_Human0.89496539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.80043785
2MP0002653_abnormal_ependyma_morphology3.34169382
3MP0003806_abnormal_nucleotide_metabolis3.32152886
4MP0000920_abnormal_myelination3.27144148
5MP0003950_abnormal_plasma_membrane3.26538219
6MP0003698_abnormal_male_reproductive2.92710675
7MP0002139_abnormal_hepatobiliary_system2.90871022
8MP0001929_abnormal_gametogenesis2.71763624
9MP0003787_abnormal_imprinting2.53178869
10MP0004133_heterotaxia2.37982496
11MP0003136_yellow_coat_color2.36813273
12MP0002102_abnormal_ear_morphology2.31966137
13MP0004043_abnormal_pH_regulation2.21896124
14MP0003195_calcinosis2.16084050
15MP0002837_dystrophic_cardiac_calcinosis2.13475208
16MP0008875_abnormal_xenobiotic_pharmacok2.05219657
17MP0001529_abnormal_vocalization1.99955208
18MP0001968_abnormal_touch/_nociception1.99921966
19MP0001905_abnormal_dopamine_level1.89816029
20MP0000372_irregular_coat_pigmentation1.83512602
21MP0000427_abnormal_hair_cycle1.82552667
22MP0005360_urolithiasis1.81423683
23MP0003122_maternal_imprinting1.78748127
24MP0004742_abnormal_vestibular_system1.77687500
25MP0005408_hypopigmentation1.75104174
26MP0002210_abnormal_sex_determination1.74803199
27MP0006292_abnormal_olfactory_placode1.74479714
28MP0005646_abnormal_pituitary_gland1.69523570
29MP0009745_abnormal_behavioral_response1.69196120
30MP0002938_white_spotting1.68895735
31MP0005645_abnormal_hypothalamus_physiol1.66980041
32MP0002736_abnormal_nociception_after1.65725562
33MP0008872_abnormal_physiological_respon1.64441899
34MP0003329_amyloid_beta_deposits1.62937261
35MP0003121_genomic_imprinting1.62163412
36MP0002161_abnormal_fertility/fecundity1.61893151
37MP0002163_abnormal_gland_morphology1.60883816
38MP0003186_abnormal_redox_activity1.60871494
39MP0004270_analgesia1.59310888
40MP0004134_abnormal_chest_morphology1.57286196
41MP0001485_abnormal_pinna_reflex1.56898662
42MP0000462_abnormal_digestive_system1.54386103
43MP0003656_abnormal_erythrocyte_physiolo1.52753986
44MP0004142_abnormal_muscle_tone1.50570417
45MP0003634_abnormal_glial_cell1.49779268
46MP0005332_abnormal_amino_acid1.48301661
47MP0008260_abnormal_autophagy1.47146463
48MP0003690_abnormal_glial_cell1.46811368
49MP0005451_abnormal_body_composition1.46294998
50MP0005365_abnormal_bile_salt1.45520756
51MP0002876_abnormal_thyroid_physiology1.45344642
52MP0001145_abnormal_male_reproductive1.44727177
53MP0003890_abnormal_embryonic-extraembry1.43448115
54MP0000631_abnormal_neuroendocrine_gland1.42673434
55MP0000566_synostosis1.42120837
56MP0008877_abnormal_DNA_methylation1.41101788
57MP0001346_abnormal_lacrimal_gland1.39798567
58MP0005171_absent_coat_pigmentation1.38740223
59MP0005085_abnormal_gallbladder_physiolo1.37108964
60MP0003718_maternal_effect1.36602782
61MP0000653_abnormal_sex_gland1.36469423
62MP0002229_neurodegeneration1.34877221
63MP0005551_abnormal_eye_electrophysiolog1.34310504
64MP0003283_abnormal_digestive_organ1.32437255
65MP0003632_abnormal_nervous_system1.32389609
66MP0005367_renal/urinary_system_phenotyp1.32212161
67MP0000516_abnormal_urinary_system1.32212161
68MP0002234_abnormal_pharynx_morphology1.28918256
69MP0005084_abnormal_gallbladder_morpholo1.27410196
70MP0002557_abnormal_social/conspecific_i1.26119000
71MP0008058_abnormal_DNA_repair1.25649772
72MP0002909_abnormal_adrenal_gland1.25087310
73MP0004885_abnormal_endolymph1.22206889
74MP0002572_abnormal_emotion/affect_behav1.21406711
75MP0009840_abnormal_foam_cell1.21342176
76MP0005389_reproductive_system_phenotype1.20976872
77MP0009046_muscle_twitch1.20763378
78MP0008789_abnormal_olfactory_epithelium1.20171969
79MP0002272_abnormal_nervous_system1.19445109
80MP0005636_abnormal_mineral_homeostasis1.18008370
81MP0002277_abnormal_respiratory_mucosa1.17101704
82MP0001501_abnormal_sleep_pattern1.16014279
83MP0001661_extended_life_span1.13586391
84MP0009250_abnormal_appendicular_skeleto1.12633228
85MP0002928_abnormal_bile_duct1.11786421
86MP0002751_abnormal_autonomic_nervous1.11777596
87MP0004019_abnormal_vitamin_homeostasis1.09283277
88MP0003937_abnormal_limbs/digits/tail_de1.08265354
89MP0001963_abnormal_hearing_physiology1.06139100
90MP0000778_abnormal_nervous_system1.05635585
91MP0005174_abnormal_tail_pigmentation1.04748112
92MP0001970_abnormal_pain_threshold1.03703169
93MP0002282_abnormal_trachea_morphology1.03594491
94MP0001984_abnormal_olfaction1.02911974
95MP0005083_abnormal_biliary_tract1.02553976
96MP0009780_abnormal_chondrocyte_physiolo1.01910892
97MP0002735_abnormal_chemical_nociception1.01594245
98MP0003119_abnormal_digestive_system1.01577266
99MP0004215_abnormal_myocardial_fiber1.01433840
100MP0001765_abnormal_ion_homeostasis1.01249593
101MP0001293_anophthalmia0.97381184
102MP0001919_abnormal_reproductive_system0.96014867
103MP0002118_abnormal_lipid_homeostasis0.94698588
104MP0002067_abnormal_sensory_capabilities0.94159405
105MP0006072_abnormal_retinal_apoptosis0.93688037
106MP0005386_behavior/neurological_phenoty0.92329340
107MP0004924_abnormal_behavior0.92329340
108MP0002295_abnormal_pulmonary_circulatio0.91935255
109MP0003631_nervous_system_phenotype0.91264325
110MP0001486_abnormal_startle_reflex0.89860764
111MP0008775_abnormal_heart_ventricle0.89839572
112MP0002734_abnormal_mechanical_nocicepti0.89410841
113MP0004147_increased_porphyrin_level0.88896295
114MP0002752_abnormal_somatic_nervous0.88778515
115MP0000647_abnormal_sebaceous_gland0.87008341
116MP0002638_abnormal_pupillary_reflex0.86472257
117MP0002733_abnormal_thermal_nociception0.85392639
118MP0002090_abnormal_vision0.84574292
119MP0003011_delayed_dark_adaptation0.83617335
120MP0005195_abnormal_posterior_eye0.83318183
121MP0006054_spinal_hemorrhage0.81434793
122MP0000762_abnormal_tongue_morphology0.81244133
123MP0001324_abnormal_eye_pigmentation0.80788456
124MP0003646_muscle_fatigue0.80642460
125MP0002233_abnormal_nose_morphology0.80372413
126MP0005391_vision/eye_phenotype0.79592051
127MP0002063_abnormal_learning/memory/cond0.79287413
128MP0003635_abnormal_synaptic_transmissio0.78947259
129MP0005394_taste/olfaction_phenotype0.78672993
130MP0005503_abnormal_tendon_morphology0.78599713
131MP0005623_abnormal_meninges_morphology0.77728859
132MP0006036_abnormal_mitochondrial_physio0.77490760
133MP0005379_endocrine/exocrine_gland_phen0.77279919
134MP0001986_abnormal_taste_sensitivity0.76874058
135MP0006276_abnormal_autonomic_nervous0.76275619
136MP0005253_abnormal_eye_physiology0.75538265
137MP0000604_amyloidosis0.74815740
138MP0000026_abnormal_inner_ear0.73986833
139MP0000383_abnormal_hair_follicle0.69295123
140MP0005058_abnormal_lysosome_morphology0.67571332
141MP0003880_abnormal_central_pattern0.67415243
142MP0001764_abnormal_homeostasis0.66153460
143MP0000613_abnormal_salivary_gland0.65848662
144MP0010678_abnormal_skin_adnexa0.65510575
145MP0001666_abnormal_nutrient_absorption0.65111276
146MP0001299_abnormal_eye_distance/0.64895252
147MP0002064_seizures0.64731979
148MP0009643_abnormal_urine_homeostasis0.63391301
149MP0001177_atelectasis0.63117557
150MP0004381_abnormal_hair_follicle0.61400154
151MP0002160_abnormal_reproductive_system0.60877235
152MP0000639_abnormal_adrenal_gland0.58371023
153MP0002882_abnormal_neuron_morphology0.58201633
154MP0005670_abnormal_white_adipose0.56232586
155MP0001542_abnormal_bone_strength0.56052649
156MP0004036_abnormal_muscle_relaxation0.55742307

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.88904653
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.55928465
3Absent/shortened dynein arms (HP:0200106)6.55928465
4Abnormal respiratory motile cilium physiology (HP:0012261)6.38745038
5Abnormal ciliary motility (HP:0012262)5.58834696
6Rhinitis (HP:0012384)5.39454244
7Abnormal respiratory motile cilium morphology (HP:0005938)5.26331457
8Abnormal respiratory epithelium morphology (HP:0012253)5.26331457
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.46745125
10Degeneration of the lateral corticospinal tracts (HP:0002314)4.46745125
11Chronic bronchitis (HP:0004469)4.01752746
12Neurofibrillary tangles (HP:0002185)3.52590439
13Abnormality of the renal cortex (HP:0011035)3.05971697
14Cystic liver disease (HP:0006706)2.99471572
15Abnormality of the corticospinal tract (HP:0002492)2.97526174
16Infertility (HP:0000789)2.94710843
17Nephronophthisis (HP:0000090)2.93779356
18Congenital stationary night blindness (HP:0007642)2.93391083
19Chronic hepatic failure (HP:0100626)2.75387691
20Sensory axonal neuropathy (HP:0003390)2.69797576
21Medial flaring of the eyebrow (HP:0010747)2.66890450
22Sclerocornea (HP:0000647)2.65453527
23Bronchiectasis (HP:0002110)2.62472722
24Irregular epiphyses (HP:0010582)2.59511353
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.53463347
26Type II lissencephaly (HP:0007260)2.47837433
27Occipital encephalocele (HP:0002085)2.45235091
28Pancreatic fibrosis (HP:0100732)2.41398364
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41078639
30Congenital hepatic fibrosis (HP:0002612)2.40520870
31Anencephaly (HP:0002323)2.36441822
32Bile duct proliferation (HP:0001408)2.34369766
33Abnormal biliary tract physiology (HP:0012439)2.34369766
34Abnormality of the renal medulla (HP:0100957)2.34214516
35Abnormality of the labia minora (HP:0012880)2.33951501
36Hyperventilation (HP:0002883)2.31688310
37Furrowed tongue (HP:0000221)2.31093380
38Cerebral hypomyelination (HP:0006808)2.30565889
39Large for gestational age (HP:0001520)2.27229782
40Cerebral inclusion bodies (HP:0100314)2.26635510
41Hemiparesis (HP:0001269)2.23742983
42Peripheral hypomyelination (HP:0007182)2.22762226
43Vaginal atresia (HP:0000148)2.22011340
44Genital tract atresia (HP:0001827)2.21863815
45Increased serum pyruvate (HP:0003542)2.20782837
46Abnormality of glycolysis (HP:0004366)2.20782837
47Parakeratosis (HP:0001036)2.18569854
48Male pseudohermaphroditism (HP:0000037)2.18214307
49Postaxial hand polydactyly (HP:0001162)2.18156778
50Abolished electroretinogram (ERG) (HP:0000550)2.17423613
51Abnormality of midbrain morphology (HP:0002418)2.17287004
52Molar tooth sign on MRI (HP:0002419)2.17287004
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16064239
54Hypoplastic pelvis (HP:0008839)2.15026183
55Progressive macrocephaly (HP:0004481)2.14444964
56Absent epiphyses (HP:0010577)2.13134532
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13134532
58Abnormal rod and cone electroretinograms (HP:0008323)2.12888970
59Polydipsia (HP:0001959)2.11272019
60Abnormal drinking behavior (HP:0030082)2.11272019
61Congenital primary aphakia (HP:0007707)2.11059116
62Gait imbalance (HP:0002141)2.10582152
63Abnormality of renal resorption (HP:0011038)2.10446129
64Intrahepatic cholestasis (HP:0001406)2.08941140
65Leukodystrophy (HP:0002415)2.08123196
663-Methylglutaconic aciduria (HP:0003535)2.07999317
67Hypomagnesemia (HP:0002917)2.07645598
68True hermaphroditism (HP:0010459)2.07570218
69Supernumerary spleens (HP:0009799)2.07305186
70Retinal dysplasia (HP:0007973)2.06808500
71Delayed epiphyseal ossification (HP:0002663)2.02186751
72Epiphyseal dysplasia (HP:0002656)2.01551994
73Tubulointerstitial nephritis (HP:0001970)2.01300901
74Hyperglycinuria (HP:0003108)2.00933695
75Mitochondrial inheritance (HP:0001427)2.00443813
76Short femoral neck (HP:0100864)1.99842504
77Hypothermia (HP:0002045)1.98922934
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.98811930
79Attenuation of retinal blood vessels (HP:0007843)1.97997385
80Nasal polyposis (HP:0100582)1.96583300
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96277694
82Renal Fanconi syndrome (HP:0001994)1.94667057
83Increased CSF lactate (HP:0002490)1.94366965
84Congenital, generalized hypertrichosis (HP:0004540)1.93811968
85Segmental peripheral demyelination/remyelination (HP:0003481)1.93543072
86Renal cortical cysts (HP:0000803)1.93313608
87Ketoacidosis (HP:0001993)1.92364762
88Pendular nystagmus (HP:0012043)1.92259231
89Hyperglycinemia (HP:0002154)1.91921911
90Poor coordination (HP:0002370)1.91716611
91Nephrogenic diabetes insipidus (HP:0009806)1.91667038
92Preaxial hand polydactyly (HP:0001177)1.89190665
93Optic nerve hypoplasia (HP:0000609)1.89077301
94Aplasia involving bones of the extremities (HP:0009825)1.88445541
95Aplasia involving bones of the upper limbs (HP:0009823)1.88445541
96Aplasia of the phalanges of the hand (HP:0009802)1.88445541
97Bilateral microphthalmos (HP:0007633)1.87530009
98Gaze-evoked nystagmus (HP:0000640)1.87135419
99Keratoconus (HP:0000563)1.86878894
100Increased corneal curvature (HP:0100692)1.86878894
101Abnormal gallbladder physiology (HP:0012438)1.86742615
102Cholecystitis (HP:0001082)1.86742615
103Acute encephalopathy (HP:0006846)1.86422505
104Abnormality of dentin (HP:0010299)1.85921319
105Lissencephaly (HP:0001339)1.84782135
106Pancreatic cysts (HP:0001737)1.84748282
107Hyperinsulinemic hypoglycemia (HP:0000825)1.83582092
108Asplenia (HP:0001746)1.82752954
109Abnormality of permanent molar morphology (HP:0011071)1.82488709
110Abnormality of the dental root (HP:0006486)1.82488709
111Taurodontia (HP:0000679)1.82488709
112Male infertility (HP:0003251)1.80425275
113Inability to walk (HP:0002540)1.78844352
114Abnormal spermatogenesis (HP:0008669)1.78843090
115Onion bulb formation (HP:0003383)1.78558320
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78527525
117Severe muscular hypotonia (HP:0006829)1.77990374
118Acute necrotizing encephalopathy (HP:0006965)1.77835890
119Abnormality of renal excretion (HP:0011036)1.76844112
120Abnormality of molar morphology (HP:0011070)1.75560272
121Abnormality of molar (HP:0011077)1.75560272
122Hypoplasia of the fovea (HP:0007750)1.72595738
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.72595738
124Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.72562145
125Hepatic necrosis (HP:0002605)1.72094835
126Progressive inability to walk (HP:0002505)1.71750442
127Tubulointerstitial abnormality (HP:0001969)1.71681285
128Dandy-Walker malformation (HP:0001305)1.71636697
129Aplasia/hypoplasia of the uterus (HP:0008684)1.71416062
130Oculomotor apraxia (HP:0000657)1.70946555
131Abnormal tarsal ossification (HP:0008369)1.70533012
132Cerebellar dysplasia (HP:0007033)1.70403155
133Tubular atrophy (HP:0000092)1.70210949
134Intestinal atresia (HP:0011100)1.69580799
135Cerebral hemorrhage (HP:0001342)1.69128693
136Narrow forehead (HP:0000341)1.69014987
137Optic disc pallor (HP:0000543)1.68512521
138Abnormality of alanine metabolism (HP:0010916)1.68482649
139Hyperalaninemia (HP:0003348)1.68482649
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68482649
141Abnormal mitochondria in muscle tissue (HP:0008316)1.68302748
142Spastic paraparesis (HP:0002313)1.67769025
143Hypokalemic alkalosis (HP:0001949)1.67607209
144Polyuria (HP:0000103)1.66994858
145Bronchitis (HP:0012387)1.66541118
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.65843117
147Abnormality of glycine metabolism (HP:0010895)1.64219945
148Abnormality of serine family amino acid metabolism (HP:0010894)1.64219945
149Methylmalonic aciduria (HP:0012120)1.63751328
150Recurrent otitis media (HP:0000403)1.63675440
151Disproportionate short-trunk short stature (HP:0003521)1.63444049
152Abnormality of the femoral head (HP:0003368)1.63012452
153Alacrima (HP:0000522)1.62453992
154Abnormality of the dental pulp (HP:0006479)1.62153585
155Vascular calcification (HP:0004934)1.61769660
156Methylmalonic acidemia (HP:0002912)1.61518559
157Postaxial foot polydactyly (HP:0001830)1.61025221
158Pheochromocytoma (HP:0002666)1.60063423
159Spastic tetraparesis (HP:0001285)1.59928196
160Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59792511
161Short tibia (HP:0005736)1.59765269
162Abnormal urine output (HP:0012590)1.59193126
163Barrel-shaped chest (HP:0001552)1.57976356
164Increased circulating renin level (HP:0000848)1.57947367
165CNS hypomyelination (HP:0003429)1.57636340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.19276010
2FRK5.20296959
3WNK44.35701086
4OXSR13.79137693
5PBK3.52408495
6PDK42.87740946
7PDK32.87740946
8MAP4K22.76119514
9MET2.51196934
10PRKD32.47821458
11ADRBK22.45729922
12PDK22.41345662
13TESK12.37861918
14ZAK2.37125458
15EPHB12.18429885
16INSRR2.18221060
17NEK62.16974636
18TRIM282.09619480
19BCR2.06312055
20MAPK152.03699349
21NUAK11.98884873
22MAPKAPK51.93482938
23WNK11.92620218
24ACVR1B1.77255591
25MST41.75124348
26LIMK11.74210726
27MAP3K41.73825028
28MKNK21.71502088
29TLK11.70774462
30FGFR21.64755139
31PKN11.64561564
32PNCK1.44049707
33PTK2B1.39368753
34PLK31.36245418
35ICK1.35474317
36VRK21.32073471
37TESK21.30615801
38MUSK1.30391291
39BMPR1B1.29990803
40STK38L1.29570304
41CSNK1G31.28095426
42ERBB31.27685975
43CDK191.26906066
44WEE11.13000047
45CSNK1A1L1.11599284
46TAOK31.10086701
47TNIK1.07918521
48WNK31.05717749
49STK161.02948176
50BUB11.02799268
51DYRK21.02546104
52SGK2231.02056886
53SGK4941.02056886
54ARAF1.01202920
55MAPKAPK31.00943889
56CSNK1G11.00777070
57EIF2AK30.99835516
58MARK10.99239362
59CAMK2B0.91312987
60ADRBK10.90542008
61IRAK20.90287104
62TSSK60.89538403
63TGFBR10.87288071
64TRPM70.86840315
65CSNK1G20.86654091
66CASK0.85985179
67MAP2K70.85159014
68EPHA40.84840339
69ERBB40.82718678
70BRSK20.82374035
71IRAK10.80890080
72CAMK2D0.80864823
73BCKDK0.78840341
74FGR0.77012968
75CAMK2G0.76721435
76UHMK10.72441426
77PRKCQ0.72126224
78ROCK20.67969748
79NTRK10.67888595
80TIE10.66072834
81DAPK20.65078936
82RPS6KA50.63679937
83PLK10.62431640
84PRKCI0.62363883
85BRAF0.60855957
86FLT30.60657592
87CDK30.59750229
88PLK40.57749941
89PASK0.52716705
90NTRK20.50392452
91MAP3K120.49812883
92NEK10.49625386
93CAMK2A0.49544942
94FER0.48530027
95NLK0.48501184
96PAK10.48101784
97MAP2K60.46999397
98PRKCE0.46254751
99PDPK10.45251910
100MAP2K20.44260167
101ABL20.44162856
102GRK10.44132916
103STK30.43318418
104CDK140.43269862
105VRK10.41779867
106PHKG20.40135025
107PHKG10.40135025
108SRPK10.39540721
109MKNK10.39524780
110NME10.38780897
111GSK3A0.37620215
112CDK150.37136605
113ATM0.36444809
114SIK10.35460329
115CAMKK20.34720062
116DYRK30.34610217
117CDK180.34262819
118PRPF4B0.33577837
119EIF2AK10.33062075
120CDK11A0.31758415
121GRK70.31459844
122EIF2AK20.31187339
123CDK80.30999914
124MAPK130.30641808
125MINK10.30124020
126TYRO30.29430407
127AURKA0.29386880
128CSNK1A10.29315292
129PRKG10.29132060
130PIK3CA0.28700897
131PRKACA0.28623715
132NTRK30.28386791
133PINK10.28250751
134TAF10.28228317
135CSNK1D0.28113253
136STK110.28047813
137PAK30.27784040
138GRK50.27645990
139PRKD10.27592576
140PDK10.27114025
141PLK20.25233897
142CHEK20.25215808
143PTK20.25004251
144PRKCG0.23917951
145PRKACB0.23306762
146DDR20.22516807
147PRKD20.22363266
148TTK0.20593292

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.71980120
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.54766009
3Steroid biosynthesis_Homo sapiens_hsa001003.49474183
4Fatty acid elongation_Homo sapiens_hsa000623.24308675
5Sulfur metabolism_Homo sapiens_hsa009202.92514694
6Protein export_Homo sapiens_hsa030602.82475665
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72493424
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63608526
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32860687
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24705176
11Oxidative phosphorylation_Homo sapiens_hsa001902.24467506
12Ether lipid metabolism_Homo sapiens_hsa005652.23496809
13Propanoate metabolism_Homo sapiens_hsa006402.15722993
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11315868
15Linoleic acid metabolism_Homo sapiens_hsa005912.02424057
16Histidine metabolism_Homo sapiens_hsa003402.00732532
17Pyruvate metabolism_Homo sapiens_hsa006201.97991464
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94688278
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79501288
20Butanoate metabolism_Homo sapiens_hsa006501.76689389
21Glutathione metabolism_Homo sapiens_hsa004801.73643487
22Peroxisome_Homo sapiens_hsa041461.70370932
23Homologous recombination_Homo sapiens_hsa034401.69873023
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68320283
25Huntingtons disease_Homo sapiens_hsa050161.67408953
26Basal transcription factors_Homo sapiens_hsa030221.57601371
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55454576
28Parkinsons disease_Homo sapiens_hsa050121.54825351
29Nicotine addiction_Homo sapiens_hsa050331.53578151
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51296243
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50067495
32Arginine and proline metabolism_Homo sapiens_hsa003301.49901755
33Chemical carcinogenesis_Homo sapiens_hsa052041.48917841
34Fatty acid metabolism_Homo sapiens_hsa012121.42131955
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38643808
36Sphingolipid metabolism_Homo sapiens_hsa006001.35416093
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33196921
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31161740
39Arachidonic acid metabolism_Homo sapiens_hsa005901.30537462
40Non-homologous end-joining_Homo sapiens_hsa034501.27203845
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.24733250
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18250991
43RNA degradation_Homo sapiens_hsa030181.18116679
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15642834
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.13673286
46Folate biosynthesis_Homo sapiens_hsa007901.13532297
47Collecting duct acid secretion_Homo sapiens_hsa049661.11476323
48Alzheimers disease_Homo sapiens_hsa050101.10195111
49Retinol metabolism_Homo sapiens_hsa008301.09762169
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08691529
51Fatty acid degradation_Homo sapiens_hsa000711.07632599
52Insulin secretion_Homo sapiens_hsa049111.07610996
53Vitamin digestion and absorption_Homo sapiens_hsa049771.02164369
54Tyrosine metabolism_Homo sapiens_hsa003501.00097658
55Selenocompound metabolism_Homo sapiens_hsa004500.99382258
56Metabolic pathways_Homo sapiens_hsa011000.97429302
57Taste transduction_Homo sapiens_hsa047420.97209172
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96576610
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.96434024
60Fatty acid biosynthesis_Homo sapiens_hsa000610.95318573
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94757628
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.93140772
63beta-Alanine metabolism_Homo sapiens_hsa004100.93031870
64Olfactory transduction_Homo sapiens_hsa047400.92355984
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91680988
66Pentose phosphate pathway_Homo sapiens_hsa000300.90352086
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88751555
68PPAR signaling pathway_Homo sapiens_hsa033200.87701369
69Phenylalanine metabolism_Homo sapiens_hsa003600.87611839
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85342556
71Glycerolipid metabolism_Homo sapiens_hsa005610.84446230
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83204696
73Tryptophan metabolism_Homo sapiens_hsa003800.83075938
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.80972810
75Mineral absorption_Homo sapiens_hsa049780.78670289
76GABAergic synapse_Homo sapiens_hsa047270.75578074
77RNA polymerase_Homo sapiens_hsa030200.74334500
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72413585
79Sulfur relay system_Homo sapiens_hsa041220.71252722
80Vibrio cholerae infection_Homo sapiens_hsa051100.70718575
81Morphine addiction_Homo sapiens_hsa050320.66820637
82Circadian entrainment_Homo sapiens_hsa047130.66246871
83Proteasome_Homo sapiens_hsa030500.64335165
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63571338
85Serotonergic synapse_Homo sapiens_hsa047260.63019662
86One carbon pool by folate_Homo sapiens_hsa006700.62558994
87Glutamatergic synapse_Homo sapiens_hsa047240.61449115
88Nucleotide excision repair_Homo sapiens_hsa034200.60817194
89Carbon metabolism_Homo sapiens_hsa012000.59927032
90Nitrogen metabolism_Homo sapiens_hsa009100.59578514
91ABC transporters_Homo sapiens_hsa020100.57564916
92Cardiac muscle contraction_Homo sapiens_hsa042600.57267361
93Salivary secretion_Homo sapiens_hsa049700.57023450
94Purine metabolism_Homo sapiens_hsa002300.56850261
95Circadian rhythm_Homo sapiens_hsa047100.56674334
96Fat digestion and absorption_Homo sapiens_hsa049750.55837175
97Mismatch repair_Homo sapiens_hsa034300.55360512
98Biosynthesis of amino acids_Homo sapiens_hsa012300.52613289
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51496776
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51001602
101Basal cell carcinoma_Homo sapiens_hsa052170.49256035
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48798895
103Complement and coagulation cascades_Homo sapiens_hsa046100.47613177
104Dopaminergic synapse_Homo sapiens_hsa047280.47462733
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43701659
106RNA transport_Homo sapiens_hsa030130.42597093
107Bile secretion_Homo sapiens_hsa049760.39963247
108Protein digestion and absorption_Homo sapiens_hsa049740.38443443
109Hippo signaling pathway_Homo sapiens_hsa043900.37997776
110Ovarian steroidogenesis_Homo sapiens_hsa049130.35970265
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35919686
112Lysosome_Homo sapiens_hsa041420.35853584
113Rheumatoid arthritis_Homo sapiens_hsa053230.34688563
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34404409
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32945601
116Calcium signaling pathway_Homo sapiens_hsa040200.32487402
117Type I diabetes mellitus_Homo sapiens_hsa049400.31733567
118Regulation of autophagy_Homo sapiens_hsa041400.30879140
119Phototransduction_Homo sapiens_hsa047440.28569760
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.28101455
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.27176226
122Hedgehog signaling pathway_Homo sapiens_hsa043400.25847562
123Other glycan degradation_Homo sapiens_hsa005110.23081595
124Phagosome_Homo sapiens_hsa041450.20470506
125Fructose and mannose metabolism_Homo sapiens_hsa000510.19273053
126Pyrimidine metabolism_Homo sapiens_hsa002400.16669298
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15337243
128Caffeine metabolism_Homo sapiens_hsa002320.13363948
129Renin-angiotensin system_Homo sapiens_hsa046140.12358513
130Fanconi anemia pathway_Homo sapiens_hsa034600.11610505
131ECM-receptor interaction_Homo sapiens_hsa045120.09728603

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