FBXO27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of dendritic spine morphogenesis (GO:0061003)6.22849030
2nerve growth factor signaling pathway (GO:0038180)5.97281329
3behavioral response to nicotine (GO:0035095)5.93079221
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89268713
5negative regulation of activin receptor signaling pathway (GO:0032926)5.42229718
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16772925
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.82290606
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80745841
9protein localization to synapse (GO:0035418)4.78549797
10positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.64962825
11neuronal action potential propagation (GO:0019227)4.63199590
12glutamate receptor signaling pathway (GO:0007215)4.58591096
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.51586065
14synaptic vesicle maturation (GO:0016188)4.44090269
15regulation of rhodopsin mediated signaling pathway (GO:0022400)4.36137455
16glomerular visceral epithelial cell development (GO:0072015)4.34369020
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.31302005
18synaptic vesicle exocytosis (GO:0016079)4.28441702
19regulation of excitatory postsynaptic membrane potential (GO:0060079)4.27133078
20regulation of glutamate receptor signaling pathway (GO:1900449)4.21393985
21cellular potassium ion homeostasis (GO:0030007)4.19487127
22fucose catabolic process (GO:0019317)4.16378120
23L-fucose metabolic process (GO:0042354)4.16378120
24L-fucose catabolic process (GO:0042355)4.16378120
25locomotory exploration behavior (GO:0035641)4.14329781
26gonadal mesoderm development (GO:0007506)4.14237577
27cerebellar Purkinje cell differentiation (GO:0021702)4.14196251
28rhodopsin mediated signaling pathway (GO:0016056)4.10418295
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.07509419
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07449649
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04304758
32synaptic transmission, glutamatergic (GO:0035249)4.03238643
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.02563403
34regulation of postsynaptic membrane potential (GO:0060078)4.02112761
35retinal cone cell development (GO:0046549)3.99263890
36regulation of dendritic spine morphogenesis (GO:0061001)3.98684371
37response to pheromone (GO:0019236)3.96577775
38glutamate secretion (GO:0014047)3.95097293
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.92240417
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.89750639
41positive regulation of dendritic spine development (GO:0060999)3.81172840
42glomerular epithelial cell development (GO:0072310)3.80264870
43mitotic cell cycle arrest (GO:0071850)3.78875207
44behavioral defense response (GO:0002209)3.77723463
45behavioral fear response (GO:0001662)3.77723463
46cell communication by electrical coupling (GO:0010644)3.75929373
47neuron-neuron synaptic transmission (GO:0007270)3.73030886
48piRNA metabolic process (GO:0034587)3.72551778
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.71635015
50chemosensory behavior (GO:0007635)3.70900986
51neuron cell-cell adhesion (GO:0007158)3.70244784
52vocalization behavior (GO:0071625)3.70071296
53DNA deamination (GO:0045006)3.67641850
54regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66951298
55response to histamine (GO:0034776)3.61991858
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55526933
57neuromuscular process controlling posture (GO:0050884)3.53818175
58regulation of neuronal synaptic plasticity (GO:0048168)3.52343502
59innervation (GO:0060384)3.50986911
60regulation of synaptic vesicle exocytosis (GO:2000300)3.47140709
61response to nerve growth factor (GO:1990089)3.44417440
62cellular response to nerve growth factor stimulus (GO:1990090)3.44417440
63positive regulation of synapse assembly (GO:0051965)3.44233158
64tryptophan catabolic process (GO:0006569)3.43825681
65indole-containing compound catabolic process (GO:0042436)3.43825681
66indolalkylamine catabolic process (GO:0046218)3.43825681
67fear response (GO:0042596)3.43740141
68membrane hyperpolarization (GO:0060081)3.41118554
69cellular ketone body metabolic process (GO:0046950)3.40986298
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39680497
71regulation of vesicle fusion (GO:0031338)3.37878285
72membrane depolarization (GO:0051899)3.35858858
73kynurenine metabolic process (GO:0070189)3.35734297
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.35521804
75cerebellar granule cell differentiation (GO:0021707)3.34765846
76UDP-N-acetylglucosamine metabolic process (GO:0006047)3.32345724
77positive regulation of membrane potential (GO:0045838)3.30933798
78indolalkylamine metabolic process (GO:0006586)3.30835363
79detection of light stimulus involved in visual perception (GO:0050908)3.25534581
80detection of light stimulus involved in sensory perception (GO:0050962)3.25534581
81neuron recognition (GO:0008038)3.25232153
82exploration behavior (GO:0035640)3.24682589
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23612729
84positive regulation of dendrite morphogenesis (GO:0050775)3.23253651
85regulation of synaptic plasticity (GO:0048167)3.21607891
86sodium ion export (GO:0071436)3.17843991
87membrane depolarization during action potential (GO:0086010)3.16057127
88axonal fasciculation (GO:0007413)3.14982184
89central nervous system projection neuron axonogenesis (GO:0021952)3.13901944
90DNA methylation involved in gamete generation (GO:0043046)3.13293550
91positive regulation of synapse maturation (GO:0090129)3.12848421
92water-soluble vitamin biosynthetic process (GO:0042364)3.12379536
93protein localization to cilium (GO:0061512)3.09678575
94SMAD protein signal transduction (GO:0060395)3.09643187
95long-term memory (GO:0007616)3.08990386
96ketone body metabolic process (GO:1902224)3.08761661
97urinary tract smooth muscle contraction (GO:0014848)3.08597959
98adult walking behavior (GO:0007628)3.08110457
99protein-cofactor linkage (GO:0018065)3.05721590
100presynaptic membrane assembly (GO:0097105)3.04729895
101protein complex biogenesis (GO:0070271)3.04704904
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02578978
103regulation of dendritic spine development (GO:0060998)3.02470877
104transmission of nerve impulse (GO:0019226)3.02235973
105gamma-aminobutyric acid transport (GO:0015812)3.00943273
106neurotransmitter secretion (GO:0007269)3.00910359
107positive regulation of guanylate cyclase activity (GO:0031284)3.00546961
108respiratory chain complex IV assembly (GO:0008535)2.99264794
109positive regulation of sodium ion transport (GO:0010765)2.99040749
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98897570
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.98897570
112NADH dehydrogenase complex assembly (GO:0010257)2.98897570
113primary amino compound metabolic process (GO:1901160)2.98083878
114long-term synaptic potentiation (GO:0060291)2.97514290
115tryptophan metabolic process (GO:0006568)2.97377808
116neurotransmitter-gated ion channel clustering (GO:0072578)2.96779143
117cell migration in hindbrain (GO:0021535)2.95029766
118regulation of synaptic vesicle transport (GO:1902803)2.94958591
119cell differentiation in hindbrain (GO:0021533)2.94527495
120negative regulation of telomere maintenance (GO:0032205)2.94312240
121positive regulation of dendrite development (GO:1900006)2.93844281
122righting reflex (GO:0060013)2.93571757
123epithelial cilium movement (GO:0003351)2.93286973
124learning (GO:0007612)2.92564614
125regulation of synapse assembly (GO:0051963)2.92210159
126short-term memory (GO:0007614)2.91499648
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.91028759
128regulation of hippo signaling (GO:0035330)2.90537474
129protein palmitoylation (GO:0018345)2.88933120
130reflex (GO:0060004)2.87888679
131mating behavior (GO:0007617)2.87652568
132mitochondrial respiratory chain complex assembly (GO:0033108)2.85781157
133preassembly of GPI anchor in ER membrane (GO:0016254)2.85740309
134neuromuscular process controlling balance (GO:0050885)2.85645799
135platelet dense granule organization (GO:0060155)2.85420666
136mitochondrial fission (GO:0000266)2.84544676
137auditory receptor cell stereocilium organization (GO:0060088)2.83306747
138indole-containing compound metabolic process (GO:0042430)2.82622212
139regulation of action potential (GO:0098900)2.82291803
140axoneme assembly (GO:0035082)2.82009887
141multicellular organism reproduction (GO:0032504)2.81703476
142presynaptic membrane organization (GO:0097090)2.81321085
143neurotransmitter transport (GO:0006836)2.80744389
144synaptic transmission, cholinergic (GO:0007271)2.78422825
145neuronal action potential (GO:0019228)2.74698348
146mannosylation (GO:0097502)2.74141087
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73757169
148behavioral response to ethanol (GO:0048149)2.72647780
149protein K11-linked deubiquitination (GO:0035871)2.72425587
150replication fork processing (GO:0031297)2.70024306
151negative regulation of reactive oxygen species metabolic process (GO:2000378)2.68397020
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66303714
153ubiquinone biosynthetic process (GO:0006744)2.66163019
154serotonin metabolic process (GO:0042428)2.65997107
155cornea development in camera-type eye (GO:0061303)2.65928244
156cytochrome complex assembly (GO:0017004)2.62763292
157positive regulation of prostaglandin secretion (GO:0032308)2.61873232
158photoreceptor cell development (GO:0042461)2.61482691
159regulation of hexokinase activity (GO:1903299)2.60369232
160regulation of glucokinase activity (GO:0033131)2.60369232
161startle response (GO:0001964)2.58292669
162positive regulation of fatty acid transport (GO:2000193)2.58097933
163nonmotile primary cilium assembly (GO:0035058)2.58066016
164photoreceptor cell maintenance (GO:0045494)2.57976927
165kidney morphogenesis (GO:0060993)2.55435616
166cilium morphogenesis (GO:0060271)2.52946454
167amino acid salvage (GO:0043102)2.52880032
168L-methionine salvage (GO:0071267)2.52880032
169L-methionine biosynthetic process (GO:0071265)2.52880032
170regulation of meiosis I (GO:0060631)2.51925423
171dopamine transport (GO:0015872)2.51430582
172regulation of mesoderm development (GO:2000380)2.51332967
173cellular response to ATP (GO:0071318)2.50992778
174detection of mechanical stimulus involved in sensory perception (GO:0050974)2.50895061
175inner ear receptor stereocilium organization (GO:0060122)2.50434483
176nephron tubule morphogenesis (GO:0072078)2.50262733
177nephron epithelium morphogenesis (GO:0072088)2.50262733
178anterograde synaptic vesicle transport (GO:0048490)2.49610131
179S-adenosylmethionine metabolic process (GO:0046500)2.48860233
180sulfation (GO:0051923)2.48315174
181regulation of acrosome reaction (GO:0060046)2.48089073
182cAMP catabolic process (GO:0006198)2.46777855
183protein polyglutamylation (GO:0018095)2.45886726
184cilium movement (GO:0003341)2.44909262
185centriole replication (GO:0007099)2.44621064
186ubiquinone metabolic process (GO:0006743)2.44328077
187negative regulation of mast cell activation (GO:0033004)2.44117903
188meiotic chromosome segregation (GO:0045132)2.43852891
189pseudouridine synthesis (GO:0001522)2.42971043
190phosphatidylserine acyl-chain remodeling (GO:0036150)2.41206938
191oxidative demethylation (GO:0070989)2.40922909
192recombinational repair (GO:0000725)2.40795041
193glycerophospholipid catabolic process (GO:0046475)2.40409369
194double-strand break repair via homologous recombination (GO:0000724)2.39313591
195reciprocal meiotic recombination (GO:0007131)2.38742008
196reciprocal DNA recombination (GO:0035825)2.38742008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01517773
2GBX2_23144817_ChIP-Seq_PC3_Human4.20105331
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.00855787
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08646975
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92035700
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75627675
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.65057231
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61867899
9IGF1R_20145208_ChIP-Seq_DFB_Human2.61716086
10REST_21632747_ChIP-Seq_MESCs_Mouse2.59560993
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55907372
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51263053
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42583971
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42583971
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42339554
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40478332
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37919949
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.36763089
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30840654
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27009353
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25830572
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17849989
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.14564516
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14393938
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.09639349
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09356053
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09110611
28TAF15_26573619_Chip-Seq_HEK293_Human2.02279085
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.01729673
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.98519769
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.97680576
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97359303
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.95639001
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92555502
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88055868
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86442721
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83065695
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79854045
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79422111
40DROSHA_22980978_ChIP-Seq_HELA_Human1.78044848
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75135908
42* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74321827
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.72045158
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70360650
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61898800
46* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61249916
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61040155
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61039505
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.59856353
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.59773302
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57236780
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56760761
53BCAT_22108803_ChIP-Seq_LS180_Human1.56558902
54TP53_22573176_ChIP-Seq_HFKS_Human1.54546267
55SMAD4_21799915_ChIP-Seq_A2780_Human1.51877524
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48199838
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48199838
58ZNF274_21170338_ChIP-Seq_K562_Hela1.47777748
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47535476
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.46675543
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46161303
62AR_21572438_ChIP-Seq_LNCaP_Human1.45968878
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45444767
64MYC_18940864_ChIP-ChIP_HL60_Human1.42949084
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41602491
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.41602491
67RNF2_27304074_Chip-Seq_NSC_Mouse1.38740542
68AR_19668381_ChIP-Seq_PC3_Human1.34495538
69IRF1_19129219_ChIP-ChIP_H3396_Human1.33510144
70SOX2_19829295_ChIP-Seq_ESCs_Human1.32881596
71NANOG_19829295_ChIP-Seq_ESCs_Human1.32881596
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32796111
73TCF4_22108803_ChIP-Seq_LS180_Human1.29284006
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.28040047
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27565752
76STAT3_23295773_ChIP-Seq_U87_Human1.26006259
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25920355
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25847608
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25629073
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.25450747
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.25105984
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23017833
83* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22108816
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.21997462
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.21932581
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21320192
87HOXB7_26014856_ChIP-Seq_BT474_Human1.21002895
88NCOR_22424771_ChIP-Seq_293T_Human1.20712216
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19426209
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18778969
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17612466
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.17404157
93RUNX2_22187159_ChIP-Seq_PCA_Human1.16728396
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16519862
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15984559
96* AR_20517297_ChIP-Seq_VCAP_Human1.15503747
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.15062831
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14733093
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14053291
100AR_25329375_ChIP-Seq_VCAP_Human1.13363134
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13300571
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13193100
103P300_19829295_ChIP-Seq_ESCs_Human1.13074383
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12537254
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12455007
106EWS_26573619_Chip-Seq_HEK293_Human1.11688477
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09822363
108VDR_22108803_ChIP-Seq_LS180_Human1.08880404
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.08866777
110* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07662973
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07566877
112TP53_16413492_ChIP-PET_HCT116_Human1.07350946
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.06739640
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06570563
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06570563
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06570563
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.06347269
118FUS_26573619_Chip-Seq_HEK293_Human1.05954736
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05144753
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.04924266
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.03407168
122* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02916158
123TCF4_23295773_ChIP-Seq_U87_Human1.02546035
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.02422381
125* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01617679
126ERA_21632823_ChIP-Seq_H3396_Human1.01468651
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01359449
128MYC_19829295_ChIP-Seq_ESCs_Human0.98575804
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98088342
130* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97885473
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.97425049
132CTCF_27219007_Chip-Seq_Bcells_Human0.97158078
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96751503
134CDX2_22108803_ChIP-Seq_LS180_Human0.96345550
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.96045551
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95931594
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95734124
138NANOG_20526341_ChIP-Seq_ESCs_Human0.95064489
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.94336379
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93836007
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.92744565
142ELK1_19687146_ChIP-ChIP_HELA_Human0.92519863
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92418101
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.92366655
145CRX_20693478_ChIP-Seq_RETINA_Mouse0.92358227
146TAF2_19829295_ChIP-Seq_ESCs_Human0.92151346
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92081196
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89948801
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89542083
150POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89494820
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88182375
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87315204
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87205852
154CBP_20019798_ChIP-Seq_JUKART_Human0.85701515
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85701515
156POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85603977
157ER_23166858_ChIP-Seq_MCF-7_Human0.85559890
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84845665
159EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84226728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.85077334
2MP0003880_abnormal_central_pattern4.96248834
3MP0003635_abnormal_synaptic_transmissio3.73953366
4MP0009745_abnormal_behavioral_response3.34661027
5MP0005551_abnormal_eye_electrophysiolog3.22704089
6MP0002735_abnormal_chemical_nociception3.11256263
7MP0002064_seizures3.02449501
8MP0004270_analgesia2.98323505
9MP0002063_abnormal_learning/memory/cond2.91205319
10MP0002102_abnormal_ear_morphology2.81827199
11MP0009046_muscle_twitch2.80601093
12MP0002272_abnormal_nervous_system2.80578855
13MP0005423_abnormal_somatic_nervous2.75338466
14MP0003195_calcinosis2.55218574
15MP0002572_abnormal_emotion/affect_behav2.49111997
16MP0001968_abnormal_touch/_nociception2.33095249
17MP0008875_abnormal_xenobiotic_pharmacok2.28161257
18MP0006072_abnormal_retinal_apoptosis2.13578942
19MP0005253_abnormal_eye_physiology2.10908397
20MP0001501_abnormal_sleep_pattern2.10771618
21MP0002837_dystrophic_cardiac_calcinosis2.10204791
22MP0000569_abnormal_digit_pigmentation2.10094965
23MP0002736_abnormal_nociception_after2.07704783
24MP0002138_abnormal_hepatobiliary_system2.06444277
25MP0001486_abnormal_startle_reflex2.00306477
26MP0002909_abnormal_adrenal_gland1.93850184
27MP0004145_abnormal_muscle_electrophysio1.92519467
28MP0002638_abnormal_pupillary_reflex1.86016245
29MP0002184_abnormal_innervation1.84980194
30MP0002734_abnormal_mechanical_nocicepti1.80139341
31MP0002067_abnormal_sensory_capabilities1.79541384
32MP0004133_heterotaxia1.79028379
33MP0003787_abnormal_imprinting1.77776015
34MP0001440_abnormal_grooming_behavior1.69187494
35MP0002882_abnormal_neuron_morphology1.69066508
36MP0000778_abnormal_nervous_system1.68575520
37MP0004043_abnormal_pH_regulation1.67812080
38MP0002229_neurodegeneration1.67788356
39MP0003136_yellow_coat_color1.67009766
40MP0000955_abnormal_spinal_cord1.66355775
41MP0003329_amyloid_beta_deposits1.65788630
42MP0005645_abnormal_hypothalamus_physiol1.65168372
43MP0000427_abnormal_hair_cycle1.61983698
44MP0002234_abnormal_pharynx_morphology1.59038445
45MP0008569_lethality_at_weaning1.59030444
46MP0003718_maternal_effect1.57960915
47MP0003011_delayed_dark_adaptation1.56922036
48MP0003632_abnormal_nervous_system1.56469758
49MP0002938_white_spotting1.55012413
50MP0003252_abnormal_bile_duct1.53819904
51MP0001970_abnormal_pain_threshold1.50226729
52MP0003646_muscle_fatigue1.45641617
53MP0003123_paternal_imprinting1.42352437
54MP0002733_abnormal_thermal_nociception1.41226032
55MP0000383_abnormal_hair_follicle1.41217683
56MP0006292_abnormal_olfactory_placode1.40616082
57MP0004811_abnormal_neuron_physiology1.40156483
58MP0002876_abnormal_thyroid_physiology1.38273139
59MP0002752_abnormal_somatic_nervous1.38012387
60MP0002090_abnormal_vision1.37801210
61MP0006276_abnormal_autonomic_nervous1.37356913
62MP0002066_abnormal_motor_capabilities/c1.35639146
63MP0002928_abnormal_bile_duct1.35281067
64MP0010386_abnormal_urinary_bladder1.34705514
65MP0002557_abnormal_social/conspecific_i1.32693271
66MP0004858_abnormal_nervous_system1.31607759
67MP0001502_abnormal_circadian_rhythm1.26580273
68MP0005085_abnormal_gallbladder_physiolo1.26123854
69MP0005174_abnormal_tail_pigmentation1.25582204
70MP0002822_catalepsy1.25575237
71MP0005195_abnormal_posterior_eye1.25042826
72MP0003878_abnormal_ear_physiology1.21126733
73MP0005377_hearing/vestibular/ear_phenot1.21126733
74MP0005084_abnormal_gallbladder_morpholo1.17866738
75MP0000647_abnormal_sebaceous_gland1.16690961
76MP0003631_nervous_system_phenotype1.16104664
77MP0003137_abnormal_impulse_conducting1.15534416
78MP0005171_absent_coat_pigmentation1.14224992
79MP0003633_abnormal_nervous_system1.10828032
80MP0004924_abnormal_behavior1.10809331
81MP0005386_behavior/neurological_phenoty1.10809331
82MP0003879_abnormal_hair_cell1.10508740
83MP0000372_irregular_coat_pigmentation1.09214008
84MP0004085_abnormal_heartbeat1.09046677
85MP0002152_abnormal_brain_morphology1.07515783
86MP0001963_abnormal_hearing_physiology1.07175586
87MP0008058_abnormal_DNA_repair1.07153567
88MP0001986_abnormal_taste_sensitivity1.03267131
89MP0001188_hyperpigmentation1.02189656
90MP0008260_abnormal_autophagy1.01798479
91MP0005075_abnormal_melanosome_morpholog1.00650031
92MP0000920_abnormal_myelination0.97395536
93MP0003890_abnormal_embryonic-extraembry0.97346627
94MP0003693_abnormal_embryo_hatching0.96777247
95MP0001299_abnormal_eye_distance/0.96609316
96MP0002653_abnormal_ependyma_morphology0.95798426
97MP0003634_abnormal_glial_cell0.95020153
98MP0000026_abnormal_inner_ear0.93311266
99MP0004215_abnormal_myocardial_fiber0.92837843
100MP0003122_maternal_imprinting0.92804376
101MP0002095_abnormal_skin_pigmentation0.92792215
102MP0004142_abnormal_muscle_tone0.91167684
103MP0004147_increased_porphyrin_level0.90895534
104MP0001348_abnormal_lacrimal_gland0.90208200
105MP0001905_abnormal_dopamine_level0.88183126
106MP0002254_reproductive_system_inflammat0.86981197
107MP0001529_abnormal_vocalization0.86428238
108MP0005410_abnormal_fertilization0.86306939
109MP0001485_abnormal_pinna_reflex0.84695225
110MP0001984_abnormal_olfaction0.84544635
111MP0005332_abnormal_amino_acid0.84505502
112MP0005083_abnormal_biliary_tract0.83857595
113MP0005389_reproductive_system_phenotype0.83660905
114MP0002160_abnormal_reproductive_system0.82461232
115MP0001324_abnormal_eye_pigmentation0.81346490
116MP0008775_abnormal_heart_ventricle0.81270239
117MP0002210_abnormal_sex_determination0.81199735
118MP0000566_synostosis0.80994889
119MP0003283_abnormal_digestive_organ0.80414188
120MP0001929_abnormal_gametogenesis0.80304948
121MP0003690_abnormal_glial_cell0.80187111
122MP0005365_abnormal_bile_salt0.79401728
123MP0002751_abnormal_autonomic_nervous0.79247874
124MP0002693_abnormal_pancreas_physiology0.78405917
125MP0004742_abnormal_vestibular_system0.77669233
126MP0004885_abnormal_endolymph0.76218754
127MP0001919_abnormal_reproductive_system0.76020491
128MP0009780_abnormal_chondrocyte_physiolo0.72854711
129MP0005391_vision/eye_phenotype0.71827667
130MP0003861_abnormal_nervous_system0.71231792
131MP0002069_abnormal_eating/drinking_beha0.71230263
132MP0003172_abnormal_lysosome_physiology0.70145631
133MP0000751_myopathy0.66019994
134MP0003698_abnormal_male_reproductive0.65287702
135MP0010769_abnormal_survival0.61905426
136MP0003950_abnormal_plasma_membrane0.61743432
137MP0000759_abnormal_skeletal_muscle0.60313317
138MP0000747_muscle_weakness0.60101523
139MP0010768_mortality/aging0.59760282
140MP0004484_altered_response_of0.59569487
141MP0005595_abnormal_vascular_smooth0.59502914
142MP0008872_abnormal_physiological_respon0.58881309
143MP0008877_abnormal_DNA_methylation0.58782465
144MP0010770_preweaning_lethality0.58254916
145MP0002082_postnatal_lethality0.58254916
146MP0000631_abnormal_neuroendocrine_gland0.57600248
147MP0005646_abnormal_pituitary_gland0.57088597

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.46940186
2Focal motor seizures (HP:0011153)7.45359708
3Myokymia (HP:0002411)7.04685912
4Dysdiadochokinesis (HP:0002075)5.20535158
5Pancreatic cysts (HP:0001737)4.58561174
6Reduced antithrombin III activity (HP:0001976)4.46256882
7Focal seizures (HP:0007359)4.20052630
8Abnormality of midbrain morphology (HP:0002418)4.01943415
9Molar tooth sign on MRI (HP:0002419)4.01943415
10Epileptic encephalopathy (HP:0200134)3.99038496
11Exotropia (HP:0000577)3.94552311
12Visual hallucinations (HP:0002367)3.87723870
13Atonic seizures (HP:0010819)3.72596291
14Broad-based gait (HP:0002136)3.71727546
15Febrile seizures (HP:0002373)3.60725280
16Dialeptic seizures (HP:0011146)3.57404156
17Dysmetria (HP:0001310)3.55837467
18Bony spicule pigmentary retinopathy (HP:0007737)3.52696568
19Nephronophthisis (HP:0000090)3.50876644
20Gaze-evoked nystagmus (HP:0000640)3.50076803
21Absence seizures (HP:0002121)3.47672471
22Gonadotropin excess (HP:0000837)3.46684417
23Annular pancreas (HP:0001734)3.45680559
24Lower limb asymmetry (HP:0100559)3.35957678
25Type II lissencephaly (HP:0007260)3.34908294
26Hypoproteinemia (HP:0003075)3.32988286
27Progressive cerebellar ataxia (HP:0002073)3.27851677
28Abnormality of the renal cortex (HP:0011035)3.22536745
29Abnormality of the renal medulla (HP:0100957)3.16606429
30Large for gestational age (HP:0001520)3.06872378
31Postural instability (HP:0002172)3.06318005
32Type I transferrin isoform profile (HP:0003642)3.03939274
33Generalized tonic-clonic seizures (HP:0002069)3.02253138
34Cystic liver disease (HP:0006706)3.01973479
35Progressive inability to walk (HP:0002505)2.94780460
36Pendular nystagmus (HP:0012043)2.90004184
37Abnormal rod and cone electroretinograms (HP:0008323)2.87010801
38Polydipsia (HP:0001959)2.82628483
39Abnormal drinking behavior (HP:0030082)2.82628483
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77406087
41Tubular atrophy (HP:0000092)2.73648884
42Chronic hepatic failure (HP:0100626)2.72060797
43Medial flaring of the eyebrow (HP:0010747)2.69170905
44Athetosis (HP:0002305)2.68449943
45Depression (HP:0000716)2.68152602
46Truncal ataxia (HP:0002078)2.67577053
47Action tremor (HP:0002345)2.67184474
48Bile duct proliferation (HP:0001408)2.65743396
49Abnormal biliary tract physiology (HP:0012439)2.65743396
50Absent speech (HP:0001344)2.65579808
51Abolished electroretinogram (ERG) (HP:0000550)2.61280934
52Hyperventilation (HP:0002883)2.55546264
53Attenuation of retinal blood vessels (HP:0007843)2.52506306
54Cutaneous finger syndactyly (HP:0010554)2.50361460
55Hemiplegia (HP:0002301)2.45600121
56Hypomagnesemia (HP:0002917)2.42465406
57Sclerocornea (HP:0000647)2.41197321
58Mask-like facies (HP:0000298)2.38191827
59Nonprogressive disorder (HP:0003680)2.38050893
60Inability to walk (HP:0002540)2.37020537
61Hemiparesis (HP:0001269)2.35732376
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.33407678
63Intention tremor (HP:0002080)2.29706330
64Abnormality of the lower motor neuron (HP:0002366)2.28843201
65Cerebellar dysplasia (HP:0007033)2.26366534
66Polyuria (HP:0000103)2.25215565
67Concave nail (HP:0001598)2.25043602
68Decreased circulating renin level (HP:0003351)2.22691437
69Lissencephaly (HP:0001339)2.22117062
70Syncope (HP:0001279)2.19424700
71Furrowed tongue (HP:0000221)2.18844214
72Gait imbalance (HP:0002141)2.17598448
73Renal cortical cysts (HP:0000803)2.17448234
74Abnormality of alanine metabolism (HP:0010916)2.16080300
75Abnormality of macular pigmentation (HP:0008002)2.13867621
76Congenital, generalized hypertrichosis (HP:0004540)2.13779966
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.13695374
78Increased CSF lactate (HP:0002490)2.11689548
79Anencephaly (HP:0002323)2.11181577
80Congenital hepatic fibrosis (HP:0002612)2.11054921
81Abnormality of the pons (HP:0007361)2.10148395
82Fair hair (HP:0002286)2.10125637
83Clumsiness (HP:0002312)2.09851051
84Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09267430
85Bradykinesia (HP:0002067)2.08230917
86Amblyopia (HP:0000646)2.07759418
87Keratoconus (HP:0000563)2.07661736
88Increased corneal curvature (HP:0100692)2.07661736
89Severe muscular hypotonia (HP:0006829)2.06709889
90Scanning speech (HP:0002168)2.05476275
91Supranuclear gaze palsy (HP:0000605)2.04583294
92Type II diabetes mellitus (HP:0005978)2.04058609
93Abnormal eating behavior (HP:0100738)2.01795489
94Hypoplasia of the pons (HP:0012110)2.00409075
95Cutaneous syndactyly (HP:0012725)1.99695688
96Diplopia (HP:0000651)1.98992551
97Abnormality of binocular vision (HP:0011514)1.98992551
98Vaginal atresia (HP:0000148)1.98465097
99Mitochondrial inheritance (HP:0001427)1.96741719
100Decreased central vision (HP:0007663)1.96527279
101Excessive salivation (HP:0003781)1.95717105
102Drooling (HP:0002307)1.95717105
103Choroideremia (HP:0001139)1.95485114
104Chorioretinal atrophy (HP:0000533)1.94998038
105Acute necrotizing encephalopathy (HP:0006965)1.94938072
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94087027
107Stomach cancer (HP:0012126)1.93220101
108Abnormality of magnesium homeostasis (HP:0004921)1.93013830
109Aplasia/hypoplasia of the uterus (HP:0008684)1.92938783
110Abnormal glycosylation (HP:0012345)1.91317814
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91317814
112Abnormal protein N-linked glycosylation (HP:0012347)1.91317814
113Abnormal protein glycosylation (HP:0012346)1.91317814
114Congenital primary aphakia (HP:0007707)1.91005314
115Genital tract atresia (HP:0001827)1.90927193
116Genetic anticipation (HP:0003743)1.89979123
117Obstructive sleep apnea (HP:0002870)1.89819797
118Postaxial foot polydactyly (HP:0001830)1.89810941
119Optic nerve hypoplasia (HP:0000609)1.89491572
120Retinal dysplasia (HP:0007973)1.89208260
121Abnormality of the columella (HP:0009929)1.88876746
122Ketoacidosis (HP:0001993)1.88857463
123Epileptiform EEG discharges (HP:0011182)1.88785070
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.88212274
125Absent/shortened dynein arms (HP:0200106)1.88212274
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.87867582
127Vascular calcification (HP:0004934)1.87109881
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.86555736
129Spastic gait (HP:0002064)1.86523362
130Protruding tongue (HP:0010808)1.86415868
131Gait ataxia (HP:0002066)1.85734556
132Tachypnea (HP:0002789)1.84925599
133Generalized myoclonic seizures (HP:0002123)1.84602990
134Pachygyria (HP:0001302)1.84177037
135Patellar aplasia (HP:0006443)1.83365497
136Palpebral edema (HP:0100540)1.83074540
137Acute encephalopathy (HP:0006846)1.82698445
138Aplasia/Hypoplasia of the patella (HP:0006498)1.82262969
139True hermaphroditism (HP:0010459)1.81368410
140Male pseudohermaphroditism (HP:0000037)1.81267140
141Colon cancer (HP:0003003)1.79864129
142Hyperglycinemia (HP:0002154)1.79843724
143Hypothermia (HP:0002045)1.79010769
144Dyschromatopsia (HP:0007641)1.77941999
145Impaired smooth pursuit (HP:0007772)1.77851825
146Lipid accumulation in hepatocytes (HP:0006561)1.75834918
147Abnormal urine output (HP:0012590)1.74630824
148Progressive macrocephaly (HP:0004481)1.74613363
149Incomplete penetrance (HP:0003829)1.73662714
150Pancreatic fibrosis (HP:0100732)1.73527252
151Poor eye contact (HP:0000817)1.73339062
152Retinitis pigmentosa (HP:0000510)1.73334669
153Occipital encephalocele (HP:0002085)1.73307529
154Ketosis (HP:0001946)1.72576138
155Supernumerary spleens (HP:0009799)1.72279408
156Optic disc pallor (HP:0000543)1.71940872
157Status epilepticus (HP:0002133)1.71910170
158Abnormality of the labia minora (HP:0012880)1.71818779
159Preaxial hand polydactyly (HP:0001177)1.71754225
160Hepatic necrosis (HP:0002605)1.70695321
161Central scotoma (HP:0000603)1.70599018
162Delusions (HP:0000746)1.69504241
163Photophobia (HP:0000613)1.68856784
164Abnormal EKG (HP:0003115)1.68339925
165Dysmetric saccades (HP:0000641)1.67179292
166Nephrogenic diabetes insipidus (HP:0009806)1.66792732
167EEG with generalized epileptiform discharges (HP:0011198)1.65848779
168Methylmalonic acidemia (HP:0002912)1.65455904
169Abnormality of the antihelix (HP:0009738)1.65162417
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64765628
171Hyperalaninemia (HP:0003348)1.64765628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.56084821
2PRPF4B5.44496518
3EPHA34.62182445
4CAMKK24.28907129
5EPHA43.92536966
6BRD43.70443611
7NTRK33.46113550
8ADRBK23.03128547
9ZAK2.88260242
10BRSK22.68996631
11MAP4K22.59985259
12BMPR1B2.59534787
13TAOK22.58008361
14MAP3K92.42221187
15WNK42.37169112
16NUAK12.36072367
17TLK12.30752310
18CAMKK11.94572091
19PRKD21.83167519
20ACVR1B1.74070475
21PAK61.70998366
22TAOK31.64298213
23BRSK11.60108030
24CASK1.59637346
25LATS11.59194062
26PNCK1.52269308
27KSR11.46179531
28KSR21.43467159
29TAF11.37846551
30CAMK2B1.35545023
31VRK21.34905685
32TAOK11.30450608
33PDGFRA1.25583255
34MAP3K121.24143832
35MARK11.23266414
36CDK31.22654242
37ADRBK11.21028521
38MINK11.20614901
39MAP3K41.19335049
40TRIM281.18840791
41MAPKAPK31.17387747
42DAPK11.13075169
43STK38L1.13072045
44PRKCG1.12502109
45STK111.12372734
46MUSK1.12355309
47STK391.12322520
48PRKCE1.10466210
49NTRK21.09684726
50PINK11.06120249
51MST41.04377084
52PRKCI1.03912112
53VRK11.01566529
54TXK1.01554212
55CAMK2A1.01327328
56DYRK21.00182130
57CDK50.97951598
58CDK190.97704100
59MKNK20.95342967
60OXSR10.93063352
61AKT30.91489975
62TRPM70.90793025
63WNK10.90310668
64BCR0.90023774
65TGFBR10.89704110
66CDK150.88233469
67CDK180.86628020
68PDPK10.86618628
69MAPK150.86434553
70CCNB10.84980141
71NTRK10.84762689
72MAPK130.84018722
73CSNK1G10.83678907
74LATS20.83413325
75WEE10.83188666
76WNK30.83036916
77GRK50.80889415
78MAPKAPK50.80713725
79STK380.80117431
80MAP2K40.79245591
81CAMK10.79133666
82MAP2K60.78763881
83CDK140.75945732
84NEK20.75945614
85CDK11A0.75097414
86RIPK40.75015240
87TSSK60.72708501
88PTK2B0.72479140
89DAPK20.69575931
90UHMK10.69456520
91PRKD10.69014991
92PLK30.66802523
93PKN10.64715628
94EIF2AK30.64439275
95CDC42BPA0.64215766
96IRAK10.63717372
97STK30.63098098
98PRKD30.61873309
99CSNK1G20.61835200
100STK160.61182364
101ALK0.58999315
102MAP2K70.58027331
103FGFR20.57656507
104PLK20.57492192
105NME10.57423477
106CAMK2D0.56837307
107ARAF0.55839220
108FER0.55708876
109NEK10.55525340
110TIE10.54941303
111MAPK70.54738546
112GRK10.54433063
113CAMK2G0.54181730
114BCKDK0.53529102
115DYRK1A0.51925109
116TNIK0.51561447
117PRKCZ0.51510915
118INSRR0.51248437
119CDC70.50952383
120CHUK0.50274012
121CSNK1G30.49116353
122IKBKB0.48791345
123MARK20.48353585
124FLT30.47780055
125PLK10.47198139
126CSNK1A1L0.46560947
127CSNK1A10.46304607
128MAPK100.46216867
129EPHB10.45088024
130ABL20.44821699
131PHKG20.44814523
132PHKG10.44814523
133SGK4940.44167694
134SGK2230.44167694
135TYRO30.43772146
136PIK3CA0.43461909
137RPS6KA30.42869765
138MAPK120.42568423
139PAK30.41393034
140PDK10.41315598
141PRKAA20.40504971
142CSNK1D0.40438864
143PRKG10.40272641
144BUB10.39848645
145MAP3K20.39115588
146NEK60.38132262
147ILK0.35694747
148MET0.35295831
149SGK10.35143674
150PRKCH0.34746288
151PAK40.33773112
152RPS6KA50.33159441
153ERBB30.32535493
154MAP3K130.32374108
155PRKCA0.32268540
156PRKAA10.31263927
157TEC0.31048618
158CSNK1E0.30128419
159PRKACA0.29801910
160PDGFRB0.29024727

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.67491236
2Nicotine addiction_Homo sapiens_hsa050334.23191974
3Long-term potentiation_Homo sapiens_hsa047203.27969208
4Glutamatergic synapse_Homo sapiens_hsa047243.25869346
5Olfactory transduction_Homo sapiens_hsa047403.17708850
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84307012
7Linoleic acid metabolism_Homo sapiens_hsa005912.77477134
8Synaptic vesicle cycle_Homo sapiens_hsa047212.76323991
9Amphetamine addiction_Homo sapiens_hsa050312.61231185
10Morphine addiction_Homo sapiens_hsa050322.60222576
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56218336
12GABAergic synapse_Homo sapiens_hsa047272.54202958
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46589983
14Circadian entrainment_Homo sapiens_hsa047132.40419918
15Butanoate metabolism_Homo sapiens_hsa006502.11584233
16Nitrogen metabolism_Homo sapiens_hsa009102.10400898
17Selenocompound metabolism_Homo sapiens_hsa004502.06868567
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.06617229
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02242030
20Oxidative phosphorylation_Homo sapiens_hsa001902.01666367
21Insulin secretion_Homo sapiens_hsa049112.00653934
22Taste transduction_Homo sapiens_hsa047421.99697000
23Dopaminergic synapse_Homo sapiens_hsa047281.97746402
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96575170
25Salivary secretion_Homo sapiens_hsa049701.94488273
26Homologous recombination_Homo sapiens_hsa034401.92458915
27Serotonergic synapse_Homo sapiens_hsa047261.91589443
28Basal transcription factors_Homo sapiens_hsa030221.84448928
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82953024
30RNA polymerase_Homo sapiens_hsa030201.79447855
31Tryptophan metabolism_Homo sapiens_hsa003801.74951872
32Renin secretion_Homo sapiens_hsa049241.73437259
33Protein export_Homo sapiens_hsa030601.71045654
34Caffeine metabolism_Homo sapiens_hsa002321.70760160
35Oxytocin signaling pathway_Homo sapiens_hsa049211.69316807
36Calcium signaling pathway_Homo sapiens_hsa040201.64773503
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.63605564
38Long-term depression_Homo sapiens_hsa047301.59185679
39Fanconi anemia pathway_Homo sapiens_hsa034601.58118232
40Cholinergic synapse_Homo sapiens_hsa047251.54757948
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53644247
42Gastric acid secretion_Homo sapiens_hsa049711.52799165
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48183951
44Parkinsons disease_Homo sapiens_hsa050121.47350764
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44602157
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44006437
47Propanoate metabolism_Homo sapiens_hsa006401.42817068
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36460988
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.34312342
50Axon guidance_Homo sapiens_hsa043601.34255622
51Collecting duct acid secretion_Homo sapiens_hsa049661.33798968
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30766865
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26086389
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22525342
55Peroxisome_Homo sapiens_hsa041461.20680547
56Gap junction_Homo sapiens_hsa045401.20226811
57Proteasome_Homo sapiens_hsa030501.19796120
58Chemical carcinogenesis_Homo sapiens_hsa052041.19211296
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18132298
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17514911
61Cardiac muscle contraction_Homo sapiens_hsa042601.14761619
62GnRH signaling pathway_Homo sapiens_hsa049121.14074993
63Retinol metabolism_Homo sapiens_hsa008301.13090794
64Circadian rhythm_Homo sapiens_hsa047101.12569709
65beta-Alanine metabolism_Homo sapiens_hsa004101.11478730
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08234754
67Type II diabetes mellitus_Homo sapiens_hsa049301.06942786
68RNA degradation_Homo sapiens_hsa030181.06919600
69One carbon pool by folate_Homo sapiens_hsa006701.05792164
70Cocaine addiction_Homo sapiens_hsa050301.05176723
71Arachidonic acid metabolism_Homo sapiens_hsa005901.03781144
72Huntingtons disease_Homo sapiens_hsa050161.01483860
73Vibrio cholerae infection_Homo sapiens_hsa051100.99555183
74cAMP signaling pathway_Homo sapiens_hsa040240.99279156
75Regulation of autophagy_Homo sapiens_hsa041400.98761225
76Ovarian steroidogenesis_Homo sapiens_hsa049130.98524220
77Oocyte meiosis_Homo sapiens_hsa041140.94254239
78Pancreatic secretion_Homo sapiens_hsa049720.93843735
79ErbB signaling pathway_Homo sapiens_hsa040120.93207541
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92486431
81Histidine metabolism_Homo sapiens_hsa003400.92347724
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91439143
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91173419
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90003439
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86504079
86VEGF signaling pathway_Homo sapiens_hsa043700.85399639
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.85273203
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84523210
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83616894
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80299804
91mRNA surveillance pathway_Homo sapiens_hsa030150.80261576
92Choline metabolism in cancer_Homo sapiens_hsa052310.79176884
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.79126988
94Purine metabolism_Homo sapiens_hsa002300.79042787
95MAPK signaling pathway_Homo sapiens_hsa040100.78029828
96Wnt signaling pathway_Homo sapiens_hsa043100.77872738
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77750267
98Dilated cardiomyopathy_Homo sapiens_hsa054140.77341840
99Fat digestion and absorption_Homo sapiens_hsa049750.77295975
100Glycerolipid metabolism_Homo sapiens_hsa005610.76301575
101Fatty acid elongation_Homo sapiens_hsa000620.75674337
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74952021
103Glioma_Homo sapiens_hsa052140.74469523
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74128223
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.73821291
106Sulfur relay system_Homo sapiens_hsa041220.73293374
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73229017
108Glucagon signaling pathway_Homo sapiens_hsa049220.72983258
109Melanogenesis_Homo sapiens_hsa049160.69359923
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67527110
111N-Glycan biosynthesis_Homo sapiens_hsa005100.67271816
112Estrogen signaling pathway_Homo sapiens_hsa049150.66267735
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66199527
114Metabolic pathways_Homo sapiens_hsa011000.64016936
115mTOR signaling pathway_Homo sapiens_hsa041500.63518522
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63338788
117Pyrimidine metabolism_Homo sapiens_hsa002400.59728602
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58718159
119Tight junction_Homo sapiens_hsa045300.56943776
120Ras signaling pathway_Homo sapiens_hsa040140.54036784
121Prion diseases_Homo sapiens_hsa050200.53588542
122Dorso-ventral axis formation_Homo sapiens_hsa043200.52699708
123Nucleotide excision repair_Homo sapiens_hsa034200.52342599
124ABC transporters_Homo sapiens_hsa020100.48756480
125Hedgehog signaling pathway_Homo sapiens_hsa043400.47686075
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47192854
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46891300
128Rap1 signaling pathway_Homo sapiens_hsa040150.46394652
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.46013660
130Thyroid hormone synthesis_Homo sapiens_hsa049180.45639164
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44568325
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44363577
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44257016
134Steroid biosynthesis_Homo sapiens_hsa001000.44071885
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.43141531
136Fatty acid degradation_Homo sapiens_hsa000710.40053044
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37561185
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36446979
139Mismatch repair_Homo sapiens_hsa034300.36389265
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35523429
141Asthma_Homo sapiens_hsa053100.35393623
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35336787
143Endocytosis_Homo sapiens_hsa041440.34876838
144Mineral absorption_Homo sapiens_hsa049780.32680644
145Ether lipid metabolism_Homo sapiens_hsa005650.32477129
146Sulfur metabolism_Homo sapiens_hsa009200.32206242
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31998201
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31709882
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31660466
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30969241
151Alzheimers disease_Homo sapiens_hsa050100.29082325
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.28475077
153Insulin signaling pathway_Homo sapiens_hsa049100.26131194
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24537751
155Galactose metabolism_Homo sapiens_hsa000520.24080396
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24061242
157Inositol phosphate metabolism_Homo sapiens_hsa005620.23744747
158Bile secretion_Homo sapiens_hsa049760.22656240
159Non-small cell lung cancer_Homo sapiens_hsa052230.22584482
160Endometrial cancer_Homo sapiens_hsa052130.21479952
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21086603
162Renal cell carcinoma_Homo sapiens_hsa052110.20319614
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18831677
164Arginine and proline metabolism_Homo sapiens_hsa003300.17929757
165HIF-1 signaling pathway_Homo sapiens_hsa040660.16283123

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