FBXO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.30067007
2locomotory exploration behavior (GO:0035641)5.13222122
3positive regulation of synapse maturation (GO:0090129)5.06289883
4neurofilament cytoskeleton organization (GO:0060052)5.00502207
5synaptic vesicle exocytosis (GO:0016079)4.96613874
6neuronal action potential propagation (GO:0019227)4.96502228
7glutamate secretion (GO:0014047)4.68682230
8amino acid import (GO:0043090)4.68183989
9detection of temperature stimulus (GO:0016048)4.46550573
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41954714
11cerebellar granule cell differentiation (GO:0021707)4.32324064
12cellular sodium ion homeostasis (GO:0006883)4.25242920
13regulation of synaptic vesicle exocytosis (GO:2000300)4.22066683
14protein polyglutamylation (GO:0018095)4.16137239
15negative regulation of microtubule polymerization (GO:0031115)4.12917912
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.09106287
17positive regulation of dendritic spine development (GO:0060999)4.00115704
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.94762194
19detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.91965562
20detection of temperature stimulus involved in sensory perception (GO:0050961)3.91965562
21auditory receptor cell differentiation (GO:0042491)3.90124875
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87801468
23neurotransmitter-gated ion channel clustering (GO:0072578)3.87429069
24sodium ion export (GO:0071436)3.85775301
25cellular potassium ion homeostasis (GO:0030007)3.85684472
26exploration behavior (GO:0035640)3.83755244
27cell migration in hindbrain (GO:0021535)3.82844873
28regulation of synapse maturation (GO:0090128)3.78365835
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.77986969
30negative regulation of dendrite morphogenesis (GO:0050774)3.72397529
31synaptic vesicle endocytosis (GO:0048488)3.67635724
32neuromuscular process controlling posture (GO:0050884)3.66834854
33innervation (GO:0060384)3.66750142
34regulation of synaptic vesicle transport (GO:1902803)3.66639280
35positive regulation of membrane potential (GO:0045838)3.65315601
36regulation of ARF protein signal transduction (GO:0032012)3.65255928
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63486530
38neurotransmitter secretion (GO:0007269)3.62285069
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.52817567
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.51344305
41transmission of nerve impulse (GO:0019226)3.50338154
42neuromuscular process controlling balance (GO:0050885)3.48515062
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48431575
44regulation of voltage-gated calcium channel activity (GO:1901385)3.46692150
45postsynaptic membrane organization (GO:0001941)3.46220115
46layer formation in cerebral cortex (GO:0021819)3.44835615
47regulation of neuronal synaptic plasticity (GO:0048168)3.41004513
48proline transport (GO:0015824)3.40893314
49cell communication by electrical coupling (GO:0010644)3.40073846
50positive regulation of neurotransmitter transport (GO:0051590)3.38343202
51cerebellar Purkinje cell layer development (GO:0021680)3.36775024
52calcium-mediated signaling using intracellular calcium source (GO:0035584)3.32588913
53vocalization behavior (GO:0071625)3.31993890
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31922032
55neurotransmitter uptake (GO:0001504)3.31831333
56synaptic transmission, glutamatergic (GO:0035249)3.31625603
57regulation of dendritic spine morphogenesis (GO:0061001)3.31239700
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24514562
59acidic amino acid transport (GO:0015800)3.23662866
60positive regulation of neurotransmitter secretion (GO:0001956)3.23495772
61mechanoreceptor differentiation (GO:0042490)3.22672022
62axon ensheathment in central nervous system (GO:0032291)3.22243483
63central nervous system myelination (GO:0022010)3.22243483
64protein localization to synapse (GO:0035418)3.18879294
65regulation of somitogenesis (GO:0014807)3.17791279
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16689809
67response to auditory stimulus (GO:0010996)3.16391823
68dendritic spine morphogenesis (GO:0060997)3.15495968
69long-term memory (GO:0007616)3.13532771
70regulation of amyloid precursor protein catabolic process (GO:1902991)3.13268279
71activation of protein kinase A activity (GO:0034199)3.11485767
72axon cargo transport (GO:0008088)3.11312087
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10277122
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08825092
75regulation of neurotransmitter transport (GO:0051588)3.08235688
76dicarboxylic acid transport (GO:0006835)3.07423517
77cerebellar Purkinje cell differentiation (GO:0021702)3.07375090
78regulation of postsynaptic membrane potential (GO:0060078)3.06785004
79neuromuscular synaptic transmission (GO:0007274)3.06262881
80regulation of dendritic spine development (GO:0060998)3.02651711
81vesicle transport along microtubule (GO:0047496)3.02024538
82chemosensory behavior (GO:0007635)3.01690835
83neuron-neuron synaptic transmission (GO:0007270)3.00528588
84neurotransmitter transport (GO:0006836)2.98167251
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.97408554
86neuronal ion channel clustering (GO:0045161)2.96788713
87dendritic spine organization (GO:0097061)2.96182054
88neuromuscular process (GO:0050905)2.93448565
89negative regulation of dendrite development (GO:2000171)2.92760371
90potassium ion import (GO:0010107)2.92691659
91regulation of synapse structural plasticity (GO:0051823)2.91930130
92L-glutamate transport (GO:0015813)2.91791039
93regulation of glutamate receptor signaling pathway (GO:1900449)2.89539693
94positive regulation of potassium ion transport (GO:0043268)2.89111520
95membrane repolarization (GO:0086009)2.89081380
96neuron cell-cell adhesion (GO:0007158)2.85239700
97membrane depolarization during action potential (GO:0086010)2.84827842
98positive regulation of dendrite development (GO:1900006)2.84681227
99glutamate receptor signaling pathway (GO:0007215)2.83407805
100potassium ion homeostasis (GO:0055075)2.83132271
101regulation of neurotransmitter levels (GO:0001505)2.80683860
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80647629
103regulation of synaptic transmission (GO:0050804)2.78260903
104organelle transport along microtubule (GO:0072384)2.73056167
105regulation of synaptic plasticity (GO:0048167)2.71442567
106synaptic vesicle transport (GO:0048489)2.71323068
107establishment of synaptic vesicle localization (GO:0097480)2.71323068
108sodium ion homeostasis (GO:0055078)2.70446068
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70435085
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.68954466
111glycine transport (GO:0015816)2.68459357
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67273975
113gamma-aminobutyric acid transport (GO:0015812)2.67035198
114cell communication involved in cardiac conduction (GO:0086065)2.65643178
115peptidyl-tyrosine autophosphorylation (GO:0038083)2.65431243
116acid secretion (GO:0046717)2.64192257
117auditory behavior (GO:0031223)2.64030895
118signal release (GO:0023061)2.63892529
119regulation of beta-amyloid formation (GO:1902003)2.63334064
120long-term synaptic potentiation (GO:0060291)2.63135083
121sensory perception of mechanical stimulus (GO:0050954)2.61860120
122regulation of cholesterol biosynthetic process (GO:0045540)2.61235187
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.59982975
124ionotropic glutamate receptor signaling pathway (GO:0035235)2.59733976
125neuronal action potential (GO:0019228)2.59704912
126negative regulation of cation channel activity (GO:2001258)2.59641335
127L-amino acid import (GO:0043092)2.59545995
128suckling behavior (GO:0001967)2.57218602
129sensory perception of sound (GO:0007605)2.56062638
130dendrite morphogenesis (GO:0048813)2.55685222
131axon development (GO:0061564)2.54296245
132regulation of vesicle fusion (GO:0031338)2.53698346
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.53420356
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53319248
135inner ear receptor cell differentiation (GO:0060113)2.53311065
136regulation of neurotransmitter secretion (GO:0046928)2.53074889
137mating behavior (GO:0007617)2.52123389
138membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.51334156
139regulation of corticosteroid hormone secretion (GO:2000846)2.50346715
140negative regulation of calcium ion transport into cytosol (GO:0010523)2.50070156
141neuron recognition (GO:0008038)2.49949991
142neuroblast proliferation (GO:0007405)2.49521071
143peripheral nervous system neuron development (GO:0048935)2.47210963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39946028
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09209690
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07423005
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05022798
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91176561
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91176561
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78845007
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.78838918
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76779946
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61162064
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58736548
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55493756
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55438275
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48179807
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.46596619
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.36946340
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.35050911
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34286368
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31637162
20REST_21632747_ChIP-Seq_MESCs_Mouse2.28597803
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.19604433
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.18831078
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.14289332
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.10093419
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01471293
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99964236
27DROSHA_22980978_ChIP-Seq_HELA_Human1.99778916
28GBX2_23144817_ChIP-Seq_PC3_Human1.98441065
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90380370
30LXR_22292898_ChIP-Seq_THP-1_Human1.84243809
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74616777
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70463680
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69314090
34AR_21572438_ChIP-Seq_LNCaP_Human1.62887031
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.56935290
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55883120
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53355481
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.51573938
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41187412
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40368448
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40139002
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38713220
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38438341
44* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38111746
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35229775
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34025431
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32837106
48* KDM2B_26808549_Chip-Seq_K562_Human1.32499618
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32398342
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30335260
51* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29902531
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29344005
53SMC4_20622854_ChIP-Seq_HELA_Human1.28824890
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27243508
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26940078
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24380225
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23100661
58TAF15_26573619_Chip-Seq_HEK293_Human1.22796150
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22675803
60AHR_22903824_ChIP-Seq_MCF-7_Human1.21916395
61P68_20966046_ChIP-Seq_HELA_Human1.18752591
62* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18337185
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17394984
64GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.17357766
65SMAD4_21799915_ChIP-Seq_A2780_Human1.17015107
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16672734
67ZNF263_19887448_ChIP-Seq_K562_Human1.16653598
68* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16008131
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15761581
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15015074
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13096937
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12690944
73* CREB1_26743006_Chip-Seq_LNCaP_Human1.12650878
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.12040381
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.11711519
76* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11486532
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11230256
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10789318
79RACK7_27058665_Chip-Seq_MCF-7_Human1.09615130
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08336557
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08024314
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05469209
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05432621
84OCT4_19829295_ChIP-Seq_ESCs_Human1.04639267
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04488643
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.04268795
87* CTCF_27219007_Chip-Seq_Bcells_Human1.04169943
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03631687
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02908655
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.02077141
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.01556936
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00393555
93AR_19668381_ChIP-Seq_PC3_Human1.00184525
94* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99762532
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99484823
96* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98901432
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97041489
98FOXA2_19822575_ChIP-Seq_HepG2_Human0.96835126
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95118670
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94932654
101EP300_21415370_ChIP-Seq_HL-1_Mouse0.94438518
102AR_25329375_ChIP-Seq_VCAP_Human0.94037639
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93529263
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92979338
105SMAD3_21741376_ChIP-Seq_EPCs_Human0.92948501
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92728548
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92513304
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92179035
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.90582792
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90229550
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90179797
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89941818
113STAT3_23295773_ChIP-Seq_U87_Human0.89449635
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89196889
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88826362
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.88422799
117MYC_19915707_ChIP-ChIP_AK7_Human0.87546925
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86693374
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86239722
120KDM2B_26808549_Chip-Seq_DND41_Human0.85878316
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.85641325
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84893842
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84317824
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84301488
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84257654
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84138396
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83842941
128ZNF274_21170338_ChIP-Seq_K562_Hela0.83761487
129* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83693272
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83041158
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82916706
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82630427
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81996646
134CLOCK_20551151_ChIP-Seq_293T_Human0.81966681
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81679355
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81679355
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.81663611
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81600461
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81446288
140DPY_21335234_ChIP-Seq_ESCs_Mouse0.81445664
141IGF1R_20145208_ChIP-Seq_DFB_Human0.81395217
142POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81230155
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80532400
144* KLF4_19829295_ChIP-Seq_ESCs_Human0.80468176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.76786863
2MP0003879_abnormal_hair_cell4.46216148
3MP0004270_analgesia3.70710418
4MP0001485_abnormal_pinna_reflex3.46557621
5MP0004858_abnormal_nervous_system3.41882785
6MP0002735_abnormal_chemical_nociception3.14706023
7MP0003878_abnormal_ear_physiology3.10258172
8MP0005377_hearing/vestibular/ear_phenot3.10258172
9MP0003880_abnormal_central_pattern3.01813219
10MP0003635_abnormal_synaptic_transmissio2.93814507
11MP0002272_abnormal_nervous_system2.64701437
12MP0001486_abnormal_startle_reflex2.63342215
13MP0001968_abnormal_touch/_nociception2.60121982
14MP0003329_amyloid_beta_deposits2.59434642
15* MP0001963_abnormal_hearing_physiology2.51731573
16MP0002734_abnormal_mechanical_nocicepti2.46082811
17MP0004885_abnormal_endolymph2.44719311
18MP0002064_seizures2.40290723
19MP0002733_abnormal_thermal_nociception2.33586490
20MP0006276_abnormal_autonomic_nervous2.33340344
21MP0009745_abnormal_behavioral_response2.32617383
22MP0009046_muscle_twitch2.31020223
23MP0002063_abnormal_learning/memory/cond2.27914083
24MP0000566_synostosis2.19028176
25MP0003123_paternal_imprinting2.17970569
26MP0009780_abnormal_chondrocyte_physiolo2.14919545
27MP0002736_abnormal_nociception_after2.10672670
28MP0001970_abnormal_pain_threshold2.04467178
29* MP0000026_abnormal_inner_ear2.01791643
30MP0002184_abnormal_innervation1.95282250
31MP0002572_abnormal_emotion/affect_behav1.89122303
32MP0008569_lethality_at_weaning1.89066741
33MP0002067_abnormal_sensory_capabilities1.85119849
34MP0000955_abnormal_spinal_cord1.76543857
35MP0004811_abnormal_neuron_physiology1.56494010
36MP0000778_abnormal_nervous_system1.51529586
37MP0005423_abnormal_somatic_nervous1.50328224
38MP0002653_abnormal_ependyma_morphology1.50208698
39* MP0002882_abnormal_neuron_morphology1.48677105
40MP0002822_catalepsy1.46113760
41MP0005623_abnormal_meninges_morphology1.42860884
42MP0002909_abnormal_adrenal_gland1.41137225
43MP0003634_abnormal_glial_cell1.36623807
44MP0001501_abnormal_sleep_pattern1.35368456
45MP0003787_abnormal_imprinting1.34267637
46MP0001984_abnormal_olfaction1.33568290
47MP0004142_abnormal_muscle_tone1.32053942
48MP0001440_abnormal_grooming_behavior1.31425846
49* MP0002229_neurodegeneration1.29528983
50MP0003690_abnormal_glial_cell1.29145274
51MP0003633_abnormal_nervous_system1.29094252
52MP0000604_amyloidosis1.28854208
53MP0005409_darkened_coat_color1.28061549
54MP0001299_abnormal_eye_distance/1.25997467
55MP0001177_atelectasis1.25669107
56MP0000534_abnormal_ureter_morphology1.24182212
57MP0002066_abnormal_motor_capabilities/c1.22437166
58MP0004742_abnormal_vestibular_system1.21817163
59MP0002557_abnormal_social/conspecific_i1.21518816
60MP0000920_abnormal_myelination1.18655649
61* MP0002752_abnormal_somatic_nervous1.18270413
62MP0001502_abnormal_circadian_rhythm1.14401765
63MP0005386_behavior/neurological_phenoty1.11946428
64MP0004924_abnormal_behavior1.11946428
65MP0005646_abnormal_pituitary_gland1.11073333
66MP0003631_nervous_system_phenotype1.10156985
67MP0002751_abnormal_autonomic_nervous1.05932080
68MP0000751_myopathy1.04590278
69MP0001348_abnormal_lacrimal_gland1.03944334
70MP0003283_abnormal_digestive_organ1.01193986
71MP0001905_abnormal_dopamine_level0.97489035
72MP0003632_abnormal_nervous_system0.94484397
73MP0000678_abnormal_parathyroid_gland0.93222985
74MP0008874_decreased_physiological_sensi0.88887141
75MP0002152_abnormal_brain_morphology0.85936043
76MP0003942_abnormal_urinary_system0.81241029
77MP0005645_abnormal_hypothalamus_physiol0.80018878
78MP0003075_altered_response_to0.75387229
79MP0004043_abnormal_pH_regulation0.73891160
80MP0003172_abnormal_lysosome_physiology0.72686761
81MP0001849_ear_inflammation0.71379908
82MP0003183_abnormal_peptide_metabolism0.70779160
83MP0003121_genomic_imprinting0.69606941
84MP0001986_abnormal_taste_sensitivity0.68011044
85MP0000762_abnormal_tongue_morphology0.67739030
86MP0004145_abnormal_muscle_electrophysio0.67418077
87MP0005167_abnormal_blood-brain_barrier0.65610301
88MP0000049_abnormal_middle_ear0.65382811
89MP0003941_abnormal_skin_development0.65071077
90MP0003938_abnormal_ear_development0.64946184
91MP0005248_abnormal_Harderian_gland0.64095876
92MP0008260_abnormal_autophagy0.63190504
93MP0003122_maternal_imprinting0.62163530
94MP0001270_distended_abdomen0.62072124
95MP0010234_abnormal_vibrissa_follicle0.61891636
96MP0002089_abnormal_postnatal_growth/wei0.61735743
97MP0001943_abnormal_respiration0.61722313
98MP0009672_abnormal_birth_weight0.60697519
99MP0005171_absent_coat_pigmentation0.59482139
100MP0002638_abnormal_pupillary_reflex0.58958771
101MP0000747_muscle_weakness0.58099177
102MP0010329_abnormal_lipoprotein_level0.57769634
103MP0002069_abnormal_eating/drinking_beha0.57748105
104MP0000579_abnormal_nail_morphology0.57491623
105MP0004134_abnormal_chest_morphology0.54999556
106MP0001188_hyperpigmentation0.54721345
107MP0004085_abnormal_heartbeat0.53928484
108MP0001346_abnormal_lacrimal_gland0.53533674
109MP0005535_abnormal_body_temperature0.53496779
110MP0010769_abnormal_survival0.53232451
111MP0001666_abnormal_nutrient_absorption0.52811249
112MP0000639_abnormal_adrenal_gland0.52746210
113MP0001529_abnormal_vocalization0.51905710
114MP0005551_abnormal_eye_electrophysiolog0.50777915
115MP0005365_abnormal_bile_salt0.49352805
116MP0002090_abnormal_vision0.49328249
117MP0003861_abnormal_nervous_system0.49268401
118MP0003705_abnormal_hypodermis_morpholog0.49247779
119MP0010768_mortality/aging0.48668415
120MP0010770_preweaning_lethality0.48539866
121MP0002082_postnatal_lethality0.48539866
122MP0001731_abnormal_postnatal_growth0.47669370
123MP0006072_abnormal_retinal_apoptosis0.47658417

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.89573798
2Epiphyseal dysplasia (HP:0002656)5.32271731
3Action tremor (HP:0002345)4.72239668
4Mixed hearing impairment (HP:0000410)4.69444564
5Focal motor seizures (HP:0011153)4.44523667
6Ulnar claw (HP:0001178)4.34702793
7Diplopia (HP:0000651)4.32594861
8Abnormality of binocular vision (HP:0011514)4.32594861
9Supranuclear gaze palsy (HP:0000605)4.10090963
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.73436797
11Megalencephaly (HP:0001355)3.59276122
12Focal seizures (HP:0007359)3.37344820
13Atonic seizures (HP:0010819)3.26031698
14Obstructive sleep apnea (HP:0002870)3.20143576
15Unilateral renal agenesis (HP:0000122)3.19232564
16Visual hallucinations (HP:0002367)3.15738107
17Abnormality of the ischium (HP:0003174)3.14080155
18Insidious onset (HP:0003587)3.12223895
19Termporal pattern (HP:0011008)3.12223895
20Pheochromocytoma (HP:0002666)3.10222214
21Hypoplastic ischia (HP:0003175)3.09809519
22Ankle clonus (HP:0011448)3.02741884
23Progressive cerebellar ataxia (HP:0002073)2.99006376
24Febrile seizures (HP:0002373)2.94140912
25Neurofibrillary tangles (HP:0002185)2.92068171
26Tetraplegia (HP:0002445)2.91735544
27Bronchomalacia (HP:0002780)2.89732925
28Bilateral microphthalmos (HP:0007633)2.89390931
29Irregular epiphyses (HP:0010582)2.83127625
30Peripheral hypomyelination (HP:0007182)2.82790306
31Cerebral hypomyelination (HP:0006808)2.81162647
32Severe Myopia (HP:0011003)2.80708423
33Aplasia involving bones of the upper limbs (HP:0009823)2.77705361
34Aplasia of the phalanges of the hand (HP:0009802)2.77705361
35Aplasia involving bones of the extremities (HP:0009825)2.77705361
36Akinesia (HP:0002304)2.77393194
37Focal dystonia (HP:0004373)2.75957729
38Neuroendocrine neoplasm (HP:0100634)2.72619035
39Status epilepticus (HP:0002133)2.68964236
40Epileptic encephalopathy (HP:0200134)2.64618363
41Segmental peripheral demyelination/remyelination (HP:0003481)2.63046630
42Neuronal loss in central nervous system (HP:0002529)2.61717319
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58875345
44Absence seizures (HP:0002121)2.58494264
45Craniofacial dystonia (HP:0012179)2.55684678
46Vitreoretinal degeneration (HP:0000655)2.54437517
47Depression (HP:0000716)2.53940771
48Anomalous pulmonary venous return (HP:0010772)2.53924316
49Deep venous thrombosis (HP:0002625)2.52498222
50Bradykinesia (HP:0002067)2.50203938
51Hammertoe (HP:0001765)2.50035505
52Hypercortisolism (HP:0001578)2.48163859
53Generalized tonic-clonic seizures (HP:0002069)2.46979985
54Cerebral inclusion bodies (HP:0100314)2.45729558
55Abnormality of the pubic bones (HP:0003172)2.43241175
56Rigidity (HP:0002063)2.42463023
57Recurrent corneal erosions (HP:0000495)2.40708117
58Mutism (HP:0002300)2.39913073
59Synostosis involving the elbow (HP:0003938)2.39512070
60Humeroradial synostosis (HP:0003041)2.39512070
61Bell-shaped thorax (HP:0001591)2.37590530
62Urinary urgency (HP:0000012)2.37312025
63Hypoplasia of the fovea (HP:0007750)2.35904670
64Aplasia/Hypoplasia of the fovea (HP:0008060)2.35904670
65Clonus (HP:0002169)2.35041336
66Sleep apnea (HP:0010535)2.34968599
67Apathy (HP:0000741)2.33564753
68Abnormal eating behavior (HP:0100738)2.33049434
69Papilledema (HP:0001085)2.31295249
70Mild short stature (HP:0003502)2.29710521
71Truncal ataxia (HP:0002078)2.28667655
72Increased circulating renin level (HP:0000848)2.27215565
73Dialeptic seizures (HP:0011146)2.26551876
74Foot dorsiflexor weakness (HP:0009027)2.24309549
75Dysmetria (HP:0001310)2.21524946
76Epileptiform EEG discharges (HP:0011182)2.19653550
77Spastic gait (HP:0002064)2.19212912
78Abnormality of the lower motor neuron (HP:0002366)2.18160526
79Anxiety (HP:0000739)2.17863731
80Turricephaly (HP:0000262)2.17554054
81Scanning speech (HP:0002168)2.17087827
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.14503267
83Absent epiphyses (HP:0010577)2.14503267
84Poor eye contact (HP:0000817)2.14279569
85Abnormality of the vitreous humor (HP:0004327)2.12015092
86Postural instability (HP:0002172)2.10462512
87Choreoathetosis (HP:0001266)2.10211809
88Neoplasm of the peripheral nervous system (HP:0100007)2.08957342
89Abnormality of the fovea (HP:0000493)2.08868534
90Enlarged epiphyses (HP:0010580)2.08795289
91Multifactorial inheritance (HP:0001426)2.08783206
92Dysdiadochokinesis (HP:0002075)2.07890886
93Abnormality of the pulmonary veins (HP:0011718)2.07875654
94Diminished motivation (HP:0000745)2.07582895
95Impaired social interactions (HP:0000735)2.03818816
96Abnormal social behavior (HP:0012433)2.03818816
97Hemiplegia (HP:0002301)2.03524744
98Hemiparesis (HP:0001269)2.02460575
99Ventricular fibrillation (HP:0001663)2.01553269
100Onion bulb formation (HP:0003383)2.00678410
101Abnormality of the foot musculature (HP:0001436)1.99751418
102Vertebral clefting (HP:0008428)1.98824908
103Abnormality of the corticospinal tract (HP:0002492)1.97584872
104Distal sensory impairment (HP:0002936)1.97142785
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95577570
106Alacrima (HP:0000522)1.95235509
107Failure to thrive in infancy (HP:0001531)1.95039142
108Morphological abnormality of the inner ear (HP:0011390)1.94619258
109Impaired vibration sensation in the lower limbs (HP:0002166)1.93544304
110Amblyopia (HP:0000646)1.93475440
111Annular pancreas (HP:0001734)1.93237523
112Insomnia (HP:0100785)1.92108034
113EEG with generalized epileptiform discharges (HP:0011198)1.91765954
114Spastic tetraparesis (HP:0001285)1.91292480
115Intention tremor (HP:0002080)1.89801327
116Autoamputation (HP:0001218)1.88653149
117Retinal dysplasia (HP:0007973)1.87644525
118Osteoarthritis (HP:0002758)1.85366874
119Distal upper limb amyotrophy (HP:0007149)1.85147284
120Upper limb amyotrophy (HP:0009129)1.85147284
121Torticollis (HP:0000473)1.84867844
122Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84263766
123Abnormality of pain sensation (HP:0010832)1.84032976
124Impaired pain sensation (HP:0007328)1.84032976
125Protuberant abdomen (HP:0001538)1.83398249
126Limb dystonia (HP:0002451)1.83246276
127Urinary bladder sphincter dysfunction (HP:0002839)1.83216511
128Rapidly progressive (HP:0003678)1.82578371
129Steppage gait (HP:0003376)1.80473564
130Postural tremor (HP:0002174)1.80170884
131Split foot (HP:0001839)1.80135590
132Decreased lacrimation (HP:0000633)1.79750908
133Athetosis (HP:0002305)1.78316736
134Anosmia (HP:0000458)1.77868336
135Delusions (HP:0000746)1.77614632
136Hypsarrhythmia (HP:0002521)1.77460502
137Thickened helices (HP:0000391)1.77369037
138Hand muscle atrophy (HP:0009130)1.77119677
139Fused cervical vertebrae (HP:0002949)1.75623611
140Incomplete penetrance (HP:0003829)1.75301971
141Dementia (HP:0000726)1.75244768
142Lower limb muscle weakness (HP:0007340)1.73235045
143CNS hypomyelination (HP:0003429)1.73059649
144Milia (HP:0001056)1.72628192
145Fragile nails (HP:0001808)1.71338109
146Impaired vibratory sensation (HP:0002495)1.71182170
147Stereotypic behavior (HP:0000733)1.69826796
148Neonatal onset (HP:0003623)1.69626882
149Pointed chin (HP:0000307)1.68348704
150Lower limb amyotrophy (HP:0007210)1.68153593
151Abnormality of the salivary glands (HP:0010286)1.66043172
152Lower limb asymmetry (HP:0100559)1.65679189
153Dysmetric saccades (HP:0000641)1.65596209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.71523637
2NTRK33.73695844
3LMTK23.56884104
4MAP3K93.37301721
5NTRK13.20391654
6MINK13.04499599
7KSR22.66888432
8EPHA42.27945190
9PRKD32.15936612
10MAP3K42.13724035
11PAK62.08270875
12PHKG22.06675218
13PHKG12.06675218
14LATS21.88210826
15ARAF1.83285025
16MAP3K21.74729317
17MAP3K121.72979372
18EPHA21.66098077
19MAP2K41.54586699
20STK391.52023539
21MAP2K71.50322295
22UHMK11.50255386
23DAPK21.42756130
24NTRK21.39221393
25LIMK11.37593119
26CAMKK11.36191919
27WNK11.34565621
28CDK51.28999842
29RET1.27177141
30WNK41.19432736
31GRK51.18255516
32CDK191.16645971
33NEK61.15949196
34MARK11.13465331
35CASK1.10902465
36SCYL21.10407257
37FGFR21.10151126
38MAPKAPK31.07126029
39STK381.04143694
40SGK4941.02707698
41SGK2231.02707698
42ICK0.97750324
43MAPK130.96763760
44PRKCG0.96355264
45BRSK10.94872505
46PINK10.94265016
47FER0.93102327
48FGFR40.92034290
49BRAF0.91223658
50MAP3K130.90887427
51KSR10.90789995
52TRIB30.89319607
53SIK20.88766281
54PAK30.87608835
55MAP3K10.81564183
56CDK140.81467005
57TESK10.79741650
58PRKCH0.78049637
59ROCK20.77970276
60PLK20.76338198
61MAP2K10.75388833
62TYRO30.72544141
63DYRK1A0.71409839
64CAMKK20.71084603
65OXSR10.70779762
66PNCK0.70739467
67PTK20.70295988
68TAOK10.69933309
69PRKG20.67856456
70RIPK40.67468317
71PDPK10.67419153
72CAMK2A0.66762762
73EPHB10.61778946
74CAMK2G0.61580562
75CSNK1G20.60786699
76MATK0.60079928
77MAPK120.58484486
78CDK180.58324838
79PDK10.58197486
80NEK10.57855699
81CDK150.57435805
82SGK20.56851625
83DAPK10.55825307
84TNK20.53789709
85MET0.53781570
86SIK10.52892220
87RPS6KA30.52794520
88PKN10.52792444
89TRPM70.52341769
90EPHA30.51751385
91CAMK40.51723309
92ALK0.50546306
93CAMK2B0.50226758
94PTK2B0.49841865
95SGK30.49486687
96CDK11A0.48873197
97TESK20.47691147
98MAPKAPK50.47651520
99RIPK10.47367912
100PRKCE0.47211885
101PRPF4B0.46975330
102MST1R0.43684432
103ADRBK10.43503322
104ERBB20.42674948
105SMG10.42423172
106PRKCZ0.42132896
107RPS6KA20.42083027
108CAMK2D0.41100457
109MAP3K110.40915962
110RAF10.39700967
111MAPK100.38421826
112CSNK1E0.38181429
113BMX0.37629261
114FGFR10.37530670
115CAMK10.36440207
116DAPK30.36006430
117PDGFRA0.35779505
118CDC42BPA0.35288753
119FYN0.35024114
120FGFR30.34337972
121MARK20.34146381
122STK110.32677417
123ROCK10.32564766
124HIPK20.31718453
125SGK10.31479311
126SRC0.31210931
127MAP2K60.29532022

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.26931218
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.75228385
3Nitrogen metabolism_Homo sapiens_hsa009102.71962058
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.65326212
5Vitamin B6 metabolism_Homo sapiens_hsa007502.51327375
6Olfactory transduction_Homo sapiens_hsa047402.31562316
7Nicotine addiction_Homo sapiens_hsa050331.97780360
8Long-term potentiation_Homo sapiens_hsa047201.95347750
9GABAergic synapse_Homo sapiens_hsa047271.93391203
10Circadian entrainment_Homo sapiens_hsa047131.91333037
11Insulin secretion_Homo sapiens_hsa049111.88162878
12Amphetamine addiction_Homo sapiens_hsa050311.85123130
13Dopaminergic synapse_Homo sapiens_hsa047281.84855445
14Glutamatergic synapse_Homo sapiens_hsa047241.82921903
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80705670
16Gastric acid secretion_Homo sapiens_hsa049711.79874097
17Dorso-ventral axis formation_Homo sapiens_hsa043201.74463144
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72483543
19Salivary secretion_Homo sapiens_hsa049701.71930112
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67464177
21Taste transduction_Homo sapiens_hsa047421.62422203
22Cholinergic synapse_Homo sapiens_hsa047251.62119124
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55009002
24Morphine addiction_Homo sapiens_hsa050321.48601181
25Cocaine addiction_Homo sapiens_hsa050301.46271543
26Arginine biosynthesis_Homo sapiens_hsa002201.42520592
27Long-term depression_Homo sapiens_hsa047301.38250546
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36331719
29Collecting duct acid secretion_Homo sapiens_hsa049661.36273224
30Melanogenesis_Homo sapiens_hsa049161.34510717
31GnRH signaling pathway_Homo sapiens_hsa049121.31432603
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31071657
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29524608
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.27942119
35Gap junction_Homo sapiens_hsa045401.24748766
36Arginine and proline metabolism_Homo sapiens_hsa003301.23146391
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23087334
38Serotonergic synapse_Homo sapiens_hsa047261.22464135
39Fatty acid biosynthesis_Homo sapiens_hsa000611.13823971
40Renin secretion_Homo sapiens_hsa049241.13815712
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11808093
42Glioma_Homo sapiens_hsa052141.11764150
43Vibrio cholerae infection_Homo sapiens_hsa051101.10874398
44Oxytocin signaling pathway_Homo sapiens_hsa049211.10381563
45ErbB signaling pathway_Homo sapiens_hsa040121.09129765
46Estrogen signaling pathway_Homo sapiens_hsa049151.08275476
47Histidine metabolism_Homo sapiens_hsa003401.06195588
48Calcium signaling pathway_Homo sapiens_hsa040201.06174414
49Axon guidance_Homo sapiens_hsa043601.03655498
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02118428
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.98333193
52Cardiac muscle contraction_Homo sapiens_hsa042600.95477764
53Hippo signaling pathway_Homo sapiens_hsa043900.93190084
54cAMP signaling pathway_Homo sapiens_hsa040240.93092714
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89315790
56Phenylalanine metabolism_Homo sapiens_hsa003600.87443307
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.81158098
58Endocytosis_Homo sapiens_hsa041440.79559358
59Thyroid hormone synthesis_Homo sapiens_hsa049180.79328690
60Type II diabetes mellitus_Homo sapiens_hsa049300.78299278
61Wnt signaling pathway_Homo sapiens_hsa043100.78024106
62Oocyte meiosis_Homo sapiens_hsa041140.77855320
63Protein digestion and absorption_Homo sapiens_hsa049740.75017651
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73495012
65Pancreatic secretion_Homo sapiens_hsa049720.71576741
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.71422344
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70738587
68VEGF signaling pathway_Homo sapiens_hsa043700.70247871
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69234336
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69195515
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67654121
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.66814916
73Hedgehog signaling pathway_Homo sapiens_hsa043400.66724932
74Biosynthesis of amino acids_Homo sapiens_hsa012300.66657210
75Prion diseases_Homo sapiens_hsa050200.66198260
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64685641
77Choline metabolism in cancer_Homo sapiens_hsa052310.64287673
78Glucagon signaling pathway_Homo sapiens_hsa049220.64226303
79Insulin signaling pathway_Homo sapiens_hsa049100.63598051
80MAPK signaling pathway_Homo sapiens_hsa040100.62967810
81Ras signaling pathway_Homo sapiens_hsa040140.62664602
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60346128
83beta-Alanine metabolism_Homo sapiens_hsa004100.59733777
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58182691
85Rap1 signaling pathway_Homo sapiens_hsa040150.57606140
86Inositol phosphate metabolism_Homo sapiens_hsa005620.57180997
87Folate biosynthesis_Homo sapiens_hsa007900.56741294
88Bile secretion_Homo sapiens_hsa049760.56132729
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55212397
90Tight junction_Homo sapiens_hsa045300.55177400
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55062821
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.54458082
93Renal cell carcinoma_Homo sapiens_hsa052110.53084477
94Endometrial cancer_Homo sapiens_hsa052130.52981194
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52122850
96Melanoma_Homo sapiens_hsa052180.51267923
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51171670
98Dilated cardiomyopathy_Homo sapiens_hsa054140.51095438
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50554947
100Basal cell carcinoma_Homo sapiens_hsa052170.49501137
101Alzheimers disease_Homo sapiens_hsa050100.46844319
102Thyroid cancer_Homo sapiens_hsa052160.46256257
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46146065
104mTOR signaling pathway_Homo sapiens_hsa041500.41447629
105Parkinsons disease_Homo sapiens_hsa050120.40320994
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39603364
107PPAR signaling pathway_Homo sapiens_hsa033200.39457103
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39060388
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38878986
110Complement and coagulation cascades_Homo sapiens_hsa046100.38459851
111Circadian rhythm_Homo sapiens_hsa047100.37459952
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37405623
113Ether lipid metabolism_Homo sapiens_hsa005650.37010133
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.36222565
115Mineral absorption_Homo sapiens_hsa049780.35286231
116Pyruvate metabolism_Homo sapiens_hsa006200.34627713
117Carbon metabolism_Homo sapiens_hsa012000.33965833
118Fatty acid metabolism_Homo sapiens_hsa012120.32757762
119AMPK signaling pathway_Homo sapiens_hsa041520.32183184
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31856099
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.31796503
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29621887

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