FBXL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)5.62005295
2axon extension involved in axon guidance (GO:0048846)5.62005295
3glomerular filtration (GO:0003094)4.74999287
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.72513577
5chondrocyte proliferation (GO:0035988)4.68307314
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.61852974
7bone trabecula formation (GO:0060346)4.55282669
8cell proliferation involved in metanephros development (GO:0072203)4.52640894
9renal filtration (GO:0097205)4.31321893
10establishment of nucleus localization (GO:0040023)4.22289378
11G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.92068851
12collagen fibril organization (GO:0030199)3.91395723
13hippo signaling (GO:0035329)3.90302519
14regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.89115083
15paraxial mesoderm development (GO:0048339)3.85405897
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.78389468
17chondrocyte development (GO:0002063)3.78340083
18camera-type eye morphogenesis (GO:0048593)3.72347879
19negative regulation of axon guidance (GO:1902668)3.66253744
20artery development (GO:0060840)3.65817867
21glomerular basement membrane development (GO:0032836)3.61065389
22negative chemotaxis (GO:0050919)3.54816586
23cell proliferation involved in kidney development (GO:0072111)3.52094101
24negative regulation of embryonic development (GO:0045992)3.50364994
25embryonic foregut morphogenesis (GO:0048617)3.49723689
26craniofacial suture morphogenesis (GO:0097094)3.45685582
27lateral sprouting from an epithelium (GO:0060601)3.44603046
28mesenchymal cell proliferation (GO:0010463)3.40234432
29outer ear morphogenesis (GO:0042473)3.37906128
30Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.34142844
31regulation of establishment of planar polarity (GO:0090175)3.33669900
32negative regulation of chondrocyte differentiation (GO:0032331)3.32693375
33negative regulation of catenin import into nucleus (GO:0035414)3.29254488
34sequestering of extracellular ligand from receptor (GO:0035581)3.28931114
35basement membrane organization (GO:0071711)3.26481949
36fibroblast migration (GO:0010761)3.24539141
37positive regulation of mesenchymal cell proliferation (GO:0002053)3.24501463
38regulation of axon extension involved in axon guidance (GO:0048841)3.23342810
39protein heterotrimerization (GO:0070208)3.22646346
40regulation of axon guidance (GO:1902667)3.21966360
41positive regulation of epithelial to mesenchymal transition (GO:0010718)3.17945106
42cell migration involved in heart development (GO:0060973)3.13621944
43midgut development (GO:0007494)3.12519382
44regulation of mesenchymal cell proliferation (GO:0010464)3.12011261
45lung lobe morphogenesis (GO:0060463)3.08222211
46embryonic forelimb morphogenesis (GO:0035115)3.07922168
47negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.05150939
48hindlimb morphogenesis (GO:0035137)3.04134477
49convergent extension (GO:0060026)3.03693885
50endothelial cell morphogenesis (GO:0001886)3.02603656
51embryonic hindlimb morphogenesis (GO:0035116)3.02266875
52lung-associated mesenchyme development (GO:0060484)2.98159240
53cardiac myofibril assembly (GO:0055003)2.97476512
54mesenchymal-epithelial cell signaling (GO:0060638)2.96592338
55branching involved in salivary gland morphogenesis (GO:0060445)2.94900749
56retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93598547
57renal system development (GO:0072001)2.93394506
58endodermal cell differentiation (GO:0035987)2.92274647
59lymphangiogenesis (GO:0001946)2.91217919
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91205633
61negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.90672219
62cochlea morphogenesis (GO:0090103)2.88646583
63dermatan sulfate biosynthetic process (GO:0030208)2.87507417
64non-canonical Wnt signaling pathway (GO:0035567)2.86077130
65regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85757843
66forelimb morphogenesis (GO:0035136)2.84637960
67positive regulation of smoothened signaling pathway (GO:0045880)2.84547853
68blood vessel maturation (GO:0001955)2.84034161
69atrial septum morphogenesis (GO:0060413)2.83870479
70regulation of non-canonical Wnt signaling pathway (GO:2000050)2.83662153
71cranial suture morphogenesis (GO:0060363)2.83453577
72tongue development (GO:0043586)2.83247187
73nucleus localization (GO:0051647)2.82821919
74embryonic cranial skeleton morphogenesis (GO:0048701)2.80237092
75middle ear morphogenesis (GO:0042474)2.79233330
76gastrulation with mouth forming second (GO:0001702)2.78441928
77lung epithelium development (GO:0060428)2.77733503
78lymph vessel development (GO:0001945)2.77353916
79myotube differentiation (GO:0014902)2.77286588
80dorsal/ventral axis specification (GO:0009950)2.77200832
81extracellular matrix assembly (GO:0085029)2.77134003
82vascular endothelial growth factor signaling pathway (GO:0038084)2.76160010
83kidney mesenchyme development (GO:0072074)2.75996383
84myelination in peripheral nervous system (GO:0022011)2.75781331
85peripheral nervous system axon ensheathment (GO:0032292)2.75781331
86metanephric mesenchyme development (GO:0072075)2.75519872
87embryonic skeletal system development (GO:0048706)2.75310917
88notochord development (GO:0030903)2.75104786
89cell migration involved in sprouting angiogenesis (GO:0002042)2.74442609
90growth hormone secretion (GO:0030252)2.74430487
91insulin-like growth factor receptor signaling pathway (GO:0048009)2.73783224
92positive regulation of BMP signaling pathway (GO:0030513)2.72835315
93mesenchyme development (GO:0060485)2.72794203
94negative regulation of cartilage development (GO:0061037)2.70717728
95smooth muscle tissue development (GO:0048745)2.70388330
96dermatan sulfate metabolic process (GO:0030205)2.69461833
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68610176
98regulation of mesoderm development (GO:2000380)2.68291050
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67427375
100positive regulation of cardiac muscle cell proliferation (GO:0060045)2.66593439
101negative regulation of cell fate specification (GO:0009996)2.66037868
102cartilage morphogenesis (GO:0060536)2.65939066
103ganglion development (GO:0061548)2.65911800
104positive regulation of cardiac muscle tissue development (GO:0055025)2.63151073
105epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.62958972
106cranial nerve morphogenesis (GO:0021602)2.62512943
107trabecula formation (GO:0060343)2.61763020
108polarized epithelial cell differentiation (GO:0030859)2.61499799
109heart morphogenesis (GO:0003007)2.60557515
110outflow tract septum morphogenesis (GO:0003148)2.59738129
111presynaptic membrane assembly (GO:0097105)2.59733039
112axonal fasciculation (GO:0007413)2.59534273
113eye morphogenesis (GO:0048592)2.59150405
114regulation of organ formation (GO:0003156)2.58984130
115embryonic appendage morphogenesis (GO:0035113)2.58630595
116embryonic limb morphogenesis (GO:0030326)2.58630595
117positive regulation of cardiac muscle tissue growth (GO:0055023)2.54081399
118postsynaptic membrane organization (GO:0001941)2.53690098
119axon extension (GO:0048675)2.50207096
120extracellular fibril organization (GO:0043206)2.46927998
121collagen metabolic process (GO:0032963)2.45766703
122neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42862215
123mesenchyme morphogenesis (GO:0072132)2.42245082
124appendage development (GO:0048736)2.39174829
125limb development (GO:0060173)2.39174829
126apical protein localization (GO:0045176)2.39132220
127radial glial cell differentiation (GO:0060019)2.38956283
128collagen catabolic process (GO:0030574)2.38158297
129cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.38020838
130ventricular cardiac muscle cell development (GO:0055015)2.37135125
131positive regulation of neuroblast proliferation (GO:0002052)2.34310340
132regulation of cardiac muscle tissue development (GO:0055024)2.33777728
133negative regulation of BMP signaling pathway (GO:0030514)2.33706671
134positive regulation of heart growth (GO:0060421)2.33011395
135presynaptic membrane organization (GO:0097090)2.31333924
136myofibril assembly (GO:0030239)2.30871425
137regulation of cardioblast differentiation (GO:0051890)2.30630230
138substrate adhesion-dependent cell spreading (GO:0034446)2.30339778
139heart valve formation (GO:0003188)2.29970925
140anterior/posterior axis specification, embryo (GO:0008595)2.29784672
141multicellular organismal macromolecule metabolic process (GO:0044259)2.29334430
142vasculature development (GO:0001944)2.27829581
143regulation of chondrocyte differentiation (GO:0032330)2.26833866
144substrate-dependent cell migration (GO:0006929)2.26638173
145positive regulation of cartilage development (GO:0061036)2.26544963
146endocardial cushion morphogenesis (GO:0003203)2.25956207
147Notch signaling involved in heart development (GO:0061314)2.24245311
148regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.23880707
149cell communication by electrical coupling (GO:0010644)2.23528563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.61919913
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34832834
3* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.84267257
4EZH2_22144423_ChIP-Seq_EOC_Human2.46224777
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.40116508
6PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.33613951
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30509203
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30509203
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29790016
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.21749659
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21079702
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.18853161
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.18031735
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.15774334
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.15756159
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14028438
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07939629
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04763704
19TP53_20018659_ChIP-ChIP_R1E_Mouse2.01545064
20ISL1_27105846_Chip-Seq_CPCs_Mouse2.00509347
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99618276
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.96112786
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94671641
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91001494
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.84112354
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84086308
27* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82769432
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82735681
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78887764
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78820163
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78686631
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72899942
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.71821992
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71352317
35* CJUN_26792858_Chip-Seq_BT549_Human1.64247781
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63644254
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.61717116
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61066298
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60465175
40* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59567105
41CLOCK_20551151_ChIP-Seq_293T_Human1.59226988
42* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58397031
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56147596
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.54586103
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51361883
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49702970
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47532466
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45839682
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45724156
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45134277
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44814997
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42384834
53* RING1B_27294783_Chip-Seq_NPCs_Mouse1.42381433
54* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41252330
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37807102
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.36142492
57* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36111104
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35997981
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34405440
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32852514
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31986054
62* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31624374
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31001698
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.30769565
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30244624
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27309550
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.26862831
68* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25487860
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24877369
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.24722220
71* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24686355
72* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24137628
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.23548376
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.21886957
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21225967
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20487514
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19508278
78TP53_18474530_ChIP-ChIP_U2OS_Human1.17920513
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17874074
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17617533
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17509543
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16581863
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16284796
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15731142
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15590789
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15206264
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14901332
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14788302
89KDM2B_26808549_Chip-Seq_K562_Human1.13386733
90AR_21909140_ChIP-Seq_LNCAP_Human1.13145174
91GBX2_23144817_ChIP-Seq_PC3_Human1.12304949
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12117917
93* P300_19829295_ChIP-Seq_ESCs_Human1.11107450
94TP53_16413492_ChIP-PET_HCT116_Human1.09838700
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09676939
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09676939
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08628147
98AHR_22903824_ChIP-Seq_MCF-7_Human1.07472757
99SOX9_26525672_Chip-Seq_HEART_Mouse1.07464949
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07365850
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06423063
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06383000
103DROSHA_22980978_ChIP-Seq_HELA_Human1.06221267
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.05118370
105TP53_23651856_ChIP-Seq_MEFs_Mouse1.04943624
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04685129
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04473753
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03044061
109* AR_21572438_ChIP-Seq_LNCaP_Human1.02819741
110FOXM1_23109430_ChIP-Seq_U2OS_Human1.01926757
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00445344
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99708806
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98912790
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98686780
115* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98379713
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.98195634
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97926431
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.97634658
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97404195
120* AR_19668381_ChIP-Seq_PC3_Human0.97010691
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.96597619
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96446129
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.96341370
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.96272943
125* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95722114
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95040433
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94977539
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.94637669
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94622431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.85622170
2MP0005503_abnormal_tendon_morphology4.02389100
3MP0003122_maternal_imprinting3.15786719
4MP0004272_abnormal_basement_membrane3.04319450
5MP0009053_abnormal_anal_canal2.96358930
6MP0003705_abnormal_hypodermis_morpholog2.87202059
7MP0000537_abnormal_urethra_morphology2.83068596
8MP0010030_abnormal_orbit_morphology2.76048681
9MP0003283_abnormal_digestive_organ2.67688187
10MP0006054_spinal_hemorrhage2.63081896
11MP0010368_abnormal_lymphatic_system2.60854042
12MP0005275_abnormal_skin_tensile2.42171563
13MP0003385_abnormal_body_wall2.39660455
14MP0003279_aneurysm2.33096573
15MP0003136_yellow_coat_color2.08385284
16MP0003121_genomic_imprinting2.07310558
17MP0003942_abnormal_urinary_system2.05776553
18MP0009250_abnormal_appendicular_skeleto2.02172526
19MP0005508_abnormal_skeleton_morphology1.96817561
20MP0002102_abnormal_ear_morphology1.96765829
21MP0002932_abnormal_joint_morphology1.94702123
22MP0005623_abnormal_meninges_morphology1.94557106
23MP0000534_abnormal_ureter_morphology1.93752591
24MP0002282_abnormal_trachea_morphology1.89145107
25MP0002249_abnormal_larynx_morphology1.83612276
26MP0003755_abnormal_palate_morphology1.72088069
27MP0003937_abnormal_limbs/digits/tail_de1.68668210
28MP0000733_abnormal_muscle_development1.67861639
29MP0000049_abnormal_middle_ear1.64797511
30MP0003115_abnormal_respiratory_system1.64650053
31MP0001958_emphysema1.64311018
32MP0000428_abnormal_craniofacial_morphol1.62672762
33MP0003123_paternal_imprinting1.61938722
34MP0002234_abnormal_pharynx_morphology1.60212639
35MP0002837_dystrophic_cardiac_calcinosis1.55596315
36MP0003935_abnormal_craniofacial_develop1.55422274
37MP0006292_abnormal_olfactory_placode1.54402976
38MP0003941_abnormal_skin_development1.51366185
39MP0005257_abnormal_intraocular_pressure1.50261924
40MP0002116_abnormal_craniofacial_bone1.42914000
41MP0000566_synostosis1.41277353
42MP0001879_abnormal_lymphatic_vessel1.38742719
43MP0002108_abnormal_muscle_morphology1.38290632
44MP0000767_abnormal_smooth_muscle1.37847929
45MP0009384_cardiac_valve_regurgitation1.36898229
46MP0002233_abnormal_nose_morphology1.36757740
47MP0001299_abnormal_eye_distance/1.34320884
48MP0005248_abnormal_Harderian_gland1.25989230
49MP0005076_abnormal_cell_differentiation1.25089078
50MP0005187_abnormal_penis_morphology1.23504543
51MP0002938_white_spotting1.22543326
52MP0000462_abnormal_digestive_system1.22348265
53MP0000432_abnormal_head_morphology1.18590220
54MP0008789_abnormal_olfactory_epithelium1.17934522
55MP0002109_abnormal_limb_morphology1.17498508
56MP0003091_abnormal_cell_migration1.17190120
57MP0005171_absent_coat_pigmentation1.13362332
58MP0003119_abnormal_digestive_system1.13058544
59MP0002089_abnormal_postnatal_growth/wei1.12297625
60MP0000163_abnormal_cartilage_morphology1.12241505
61MP0002295_abnormal_pulmonary_circulatio1.11741848
62MP0002925_abnormal_cardiovascular_devel1.05910087
63MP0003950_abnormal_plasma_membrane1.05115380
64MP0004134_abnormal_chest_morphology1.04731600
65MP0002653_abnormal_ependyma_morphology1.04646836
66MP0002115_abnormal_skeleton_extremities1.04608498
67MP0003566_abnormal_cell_adhesion1.03916640
68MP0004084_abnormal_cardiac_muscle1.03307687
69MP0006138_congestive_heart_failure1.03197752
70MP0003890_abnormal_embryonic-extraembry1.00409595
71MP0002177_abnormal_outer_ear1.00237510
72MP0002697_abnormal_eye_size0.99374144
73MP0000778_abnormal_nervous_system0.97706898
74MP0002084_abnormal_developmental_patter0.97160671
75MP0004197_abnormal_fetal_growth/weight/0.96725860
76MP0002085_abnormal_embryonic_tissue0.96602402
77MP0002113_abnormal_skeleton_development0.95898579
78MP0001293_anophthalmia0.95104231
79MP0002111_abnormal_tail_morphology0.93703297
80MP0009780_abnormal_chondrocyte_physiolo0.93275457
81MP0001915_intracranial_hemorrhage0.93270905
82MP0002114_abnormal_axial_skeleton0.92746383
83MP0002896_abnormal_bone_mineralization0.91180115
84MP0000751_myopathy0.90891786
85MP0003315_abnormal_perineum_morphology0.90796222
86MP0002092_abnormal_eye_morphology0.88550858
87MP0004145_abnormal_muscle_electrophysio0.88333956
88MP0005499_abnormal_olfactory_system0.88028435
89MP0005394_taste/olfaction_phenotype0.88028435
90MP0001614_abnormal_blood_vessel0.86824103
91MP0004859_abnormal_synaptic_plasticity0.86823528
92MP0005409_darkened_coat_color0.86139003
93MP0001340_abnormal_eyelid_morphology0.85377863
94MP0005620_abnormal_muscle_contractility0.84538937
95MP0001177_atelectasis0.84497950
96MP0001542_abnormal_bone_strength0.83864431
97MP0002128_abnormal_blood_circulation0.83489412
98MP0003861_abnormal_nervous_system0.83463346
99MP0004036_abnormal_muscle_relaxation0.83400645
100MP0005197_abnormal_uvea_morphology0.82328843
101MP0001286_abnormal_eye_development0.81694598
102MP0009703_decreased_birth_body0.81675747
103MP0001849_ear_inflammation0.81633577
104MP0003938_abnormal_ear_development0.81484875
105MP0009697_abnormal_copulation0.80111874
106MP0004215_abnormal_myocardial_fiber0.79722872
107MP0002060_abnormal_skin_morphology0.79679619
108MP0000569_abnormal_digit_pigmentation0.79672267
109MP0005023_abnormal_wound_healing0.78908782
110MP0000749_muscle_degeneration0.77740923
111MP0000266_abnormal_heart_morphology0.76072426
112MP0000762_abnormal_tongue_morphology0.75297832
113MP0003567_abnormal_fetal_cardiomyocyte0.75246474
114MP0000467_abnormal_esophagus_morphology0.75244947
115MP0002168_other_aberrant_phenotype0.75176217
116MP0000026_abnormal_inner_ear0.75110445
117MP0004885_abnormal_endolymph0.74552990
118MP0010352_gastrointestinal_tract_polyps0.73775269
119MP0001175_abnormal_lung_morphology0.73096081
120MP0002127_abnormal_cardiovascular_syste0.72491082
121MP0005595_abnormal_vascular_smooth0.72423458
122MP0004858_abnormal_nervous_system0.70317765
123MP0002081_perinatal_lethality0.65512889
124MP0008775_abnormal_heart_ventricle0.65453395
125MP0004087_abnormal_muscle_fiber0.65199234
126MP0004085_abnormal_heartbeat0.64813130
127MP0005369_muscle_phenotype0.64114025
128MP0002133_abnormal_respiratory_system0.64044197

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.41579750
2Shallow orbits (HP:0000586)5.25559108
3Premature rupture of membranes (HP:0001788)4.76200452
4Short 4th metacarpal (HP:0010044)4.46218012
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.46218012
6Broad metatarsal (HP:0001783)3.67460043
7Abnormality of the 4th metacarpal (HP:0010012)3.56580086
8Bladder diverticulum (HP:0000015)3.42165836
9Ankle contracture (HP:0006466)3.41141297
10Aortic dissection (HP:0002647)3.39246205
11Cerebral aneurysm (HP:0004944)3.28138103
12Aortic aneurysm (HP:0004942)3.11168950
13Soft skin (HP:0000977)2.93850403
14Renal duplication (HP:0000075)2.87016372
15Vascular tortuosity (HP:0004948)2.81139114
16Abnormality of dentin (HP:0010299)2.70964601
17Syringomyelia (HP:0003396)2.69646293
18Spinal cord lesions (HP:0100561)2.69646293
19Wrist flexion contracture (HP:0001239)2.62706590
20Bowel diverticulosis (HP:0005222)2.55633991
21Midline defect of the nose (HP:0004122)2.52104140
22Morphological abnormality of the middle ear (HP:0008609)2.52073938
23Dilatation of the ascending aorta (HP:0005111)2.51875816
24Partial duplication of the phalanx of hand (HP:0009999)2.49543132
25Asymmetry of the thorax (HP:0001555)2.49141577
26Mitral valve prolapse (HP:0001634)2.46343181
27Peritonitis (HP:0002586)2.46102614
28Atrophic scars (HP:0001075)2.43501696
29Coronal craniosynostosis (HP:0004440)2.42122690
30Camptodactyly of toe (HP:0001836)2.41463151
31Limited hip movement (HP:0008800)2.38928058
32Turricephaly (HP:0000262)2.37966689
33Deviation of the hallux (HP:0010051)2.37599826
34Lymphangioma (HP:0100764)2.34866081
35Blue sclerae (HP:0000592)2.34841977
36Buphthalmos (HP:0000557)2.32108322
37Wide anterior fontanel (HP:0000260)2.31570444
38Arterial tortuosity (HP:0005116)2.29275546
39Hallux valgus (HP:0001822)2.28633114
40Hip contracture (HP:0003273)2.27618393
41Genu recurvatum (HP:0002816)2.26099185
42Aneurysm (HP:0002617)2.24911945
43Wormian bones (HP:0002645)2.23674135
44Microglossia (HP:0000171)2.22967994
45Type 1 muscle fiber predominance (HP:0003803)2.22064780
46Fragile skin (HP:0001030)2.21926097
47Partial duplication of thumb phalanx (HP:0009944)2.21848101
48Ulnar bowing (HP:0003031)2.17837919
49Cervical subluxation (HP:0003308)2.17294323
50Mesomelia (HP:0003027)2.17102142
51Abnormality of the ischium (HP:0003174)2.16662303
52Broad toe (HP:0001837)2.16184617
53Spinal rigidity (HP:0003306)2.14790993
54Joint laxity (HP:0001388)2.13227522
55Hyperextensible skin (HP:0000974)2.09275464
56Bilateral microphthalmos (HP:0007633)2.08667840
57Abnormality of the parietal bone (HP:0002696)2.08522891
58Spondylolisthesis (HP:0003302)2.08465359
59Aortic valve stenosis (HP:0001650)2.07557136
60Knee flexion contracture (HP:0006380)2.07274332
61Broad ribs (HP:0000885)2.06407903
62Narrow nasal bridge (HP:0000446)2.03118334
63Septo-optic dysplasia (HP:0100842)2.00628277
64Hypoplasia of the iris (HP:0007676)1.99485493
65Cutaneous finger syndactyly (HP:0010554)1.99336220
66Short nail (HP:0001799)1.97937080
67Hepatoblastoma (HP:0002884)1.97376836
68Neonatal short-limb short stature (HP:0008921)1.97122107
69Broad long bones (HP:0005622)1.96257149
70Narrow palate (HP:0000189)1.95399524
71Elbow flexion contracture (HP:0002987)1.94713481
72Flat cornea (HP:0007720)1.94449813
73Hypoventilation (HP:0002791)1.91946360
74Hypoplastic ischia (HP:0003175)1.90946777
75Abnormality of the diencephalon (HP:0010662)1.89987666
76Pulmonary artery stenosis (HP:0004415)1.88861880
77Abnormality of the pubic bones (HP:0003172)1.88491724
78Follicular hyperkeratosis (HP:0007502)1.87385300
79Hyperacusis (HP:0010780)1.86371562
80Vitreoretinal degeneration (HP:0000655)1.85848760
81Aortic regurgitation (HP:0001659)1.85663958
82Renovascular hypertension (HP:0100817)1.84757775
83Abnormality of the phalanges of the hallux (HP:0010057)1.83774492
84Increased variability in muscle fiber diameter (HP:0003557)1.83281249
85Mild short stature (HP:0003502)1.82166262
86Synostosis of carpal bones (HP:0005048)1.82124736
87Flexion contracture of toe (HP:0005830)1.81250787
88Joint contractures involving the joints of the feet (HP:0100492)1.81250787
89Biconcave vertebral bodies (HP:0004586)1.81244046
90Skull defect (HP:0001362)1.81063008
91Increased connective tissue (HP:0009025)1.78891281
92Broad phalanx (HP:0006009)1.78648061
93Thin ribs (HP:0000883)1.77852832
94Infantile muscular hypotonia (HP:0008947)1.77116170
95Thin bony cortex (HP:0002753)1.75822986
96Slender build (HP:0001533)1.75449964
97Bell-shaped thorax (HP:0001591)1.75309339
98Abnormality of the acetabulum (HP:0003170)1.74241446
99Preaxial foot polydactyly (HP:0001841)1.74012977
100Disproportionate tall stature (HP:0001519)1.73937788
101Aplasia/Hypoplasia of the clavicles (HP:0006710)1.73783648
102Ectopia lentis (HP:0001083)1.73730470
103Overgrowth (HP:0001548)1.73242386
104Calcaneovalgus deformity (HP:0001848)1.72833746
105Synostosis involving bones of the feet (HP:0009140)1.69522439
106Synostosis involving bones of the lower limbs (HP:0009138)1.69522439
107Trigonocephaly (HP:0000243)1.69156395
108Deformed tarsal bones (HP:0008119)1.69092653
109Abnormal number of incisors (HP:0011064)1.68089269
110Cutaneous syndactyly (HP:0012725)1.67380928
111Broad hallux (HP:0010055)1.67231096
112Mildly elevated creatine phosphokinase (HP:0008180)1.67060474
113Aplasia involving bones of the extremities (HP:0009825)1.66854618
114Aplasia involving bones of the upper limbs (HP:0009823)1.66854618
115Aplasia of the phalanges of the hand (HP:0009802)1.66854618
116Sacral dimple (HP:0000960)1.66829052
117Mitral regurgitation (HP:0001653)1.66546496
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66097269
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.66017637
120Broad palm (HP:0001169)1.65845488
121Vertebral arch anomaly (HP:0008438)1.65691366
122Short 5th finger (HP:0009237)1.64966654
123Broad finger (HP:0001500)1.64928377
124Arachnodactyly (HP:0001166)1.63896891
125Abnormality of the anterior chamber (HP:0000593)1.63787574
126Broad phalanges of the hand (HP:0009768)1.63589335
127Tarsal synostosis (HP:0008368)1.63474394
128Short hallux (HP:0010109)1.62800396
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62472137
130Venous insufficiency (HP:0005293)1.61799119
131Short clavicles (HP:0000894)1.61741573
132Absent frontal sinuses (HP:0002688)1.60328762
133Keratoconus (HP:0000563)1.59069752
134Increased corneal curvature (HP:0100692)1.59069752
135Broad thumb (HP:0011304)1.57379267
136Round ear (HP:0100830)1.56310524
137Abnormality of the middle phalanges of the toes (HP:0010183)1.55998690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.51704445
2LATS14.36549737
3LATS23.50825692
4MYLK3.20729122
5DDR23.03465136
6KSR12.88965999
7TIE12.57514900
8PDGFRA2.39533305
9PKN22.33703648
10TRIB32.32159552
11NTRK12.29176497
12PNCK2.29153617
13TTN2.07280337
14PAK62.05363755
15SIK11.99445810
16MARK11.97860236
17PAK31.94799387
18RIPK11.91691451
19MAP3K101.89641271
20EPHA31.79140586
21ERBB41.73232445
22TNIK1.72567427
23TGFBR11.57895481
24FER1.48470811
25ERBB21.45775502
26EEF2K1.45432137
27DMPK1.45128490
28STK31.39085707
29KDR1.33281399
30PAK21.33145786
31NTRK21.32556186
32STK38L1.27979351
33PRKD31.27426263
34MOS1.25993768
35CASK1.21652592
36NEK91.21379456
37PTK21.18791158
38CAMK1D1.14729208
39PTK2B1.12770641
40TGFBR21.10887631
41PTK61.10466320
42FGFR21.09421151
43WEE11.08729712
44MTOR1.07465665
45CAMK1G1.05005655
46DYRK20.99006323
47FGFR10.98096086
48CDK120.96078866
49ERN10.93369136
50EPHA40.92824915
51MAPK70.92127989
52ERBB30.90465846
53ROCK10.87774346
54PAK40.84373383
55CDC70.80173222
56NLK0.79821515
57MUSK0.77662834
58STK380.76939476
59PLK40.76907242
60NTRK30.74399797
61PKN10.73814328
62BCR0.73687802
63PLK20.73409171
64BRSK10.72484686
65CAMK10.71535411
66PDGFRB0.69960625
67ICK0.69709964
68BMPR1B0.68435682
69UHMK10.68327108
70PIK3CA0.68084998
71RPS6KA20.67861671
72TYRO30.66382064
73MKNK20.66348323
74MAPK130.65929111
75LMTK20.64074212
76NEK20.63986472
77CDC42BPA0.63854253
78ROCK20.63177418
79SIK30.62585056
80TAOK20.61977539
81MAPK150.61393775
82TTK0.61289674
83WNK30.61240041
84BMX0.61079223
85AKT30.60540334
86MET0.59014897
87PRKCE0.57755524
88RET0.56773134
89FLT30.56759558
90CDK180.56158612
91MAP2K10.53313165
92GSK3A0.52320546
93MELK0.51818484
94CDK150.50727409
95SGK20.50504060
96KSR20.49561292
97DAPK30.48281924
98DYRK1B0.47782384
99WNK10.47390677
100NUAK10.47111289
101CDK140.47026026
102CDK80.46405358
103CSNK1A1L0.46185490
104CAMK2D0.46135024
105MAP3K90.45879715
106CHEK20.42987979
107SGK2230.41942070
108SGK4940.41942070
109MAP3K40.41916342
110PRKCH0.41859332
111EPHB10.41722780
112TAOK10.41563475
113CDK90.41490882
114MAP3K70.41136427
115CAMK2A0.41121174
116ADRBK10.41058918
117TAF10.40674522
118SGK30.40078100
119CDK11A0.39711906
120BRSK20.38888172
121CAMK2B0.38548598
122CAMK2G0.38078585
123LRRK20.37995148
124RPS6KL10.37554054
125RPS6KC10.37554054
126PRKCG0.37289316
127MAP3K60.35443452
128PRKAA10.35429374
129AKT10.34771677
130LIMK10.34741430
131CDK60.34562808
132CSNK1G10.33606371
133MAPK90.33231385
134MARK20.32167443
135SRC0.32033618
136PRKD10.31654521
137PRPF4B0.31646252
138ABL20.29757794
139PRKD20.29618115
140SCYL20.27095474
141CSNK1G20.27006707

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.66891664
2Hedgehog signaling pathway_Homo sapiens_hsa043402.88027936
3ECM-receptor interaction_Homo sapiens_hsa045122.75240651
4Hippo signaling pathway_Homo sapiens_hsa043902.64615729
5Adherens junction_Homo sapiens_hsa045202.56633236
6Focal adhesion_Homo sapiens_hsa045102.35911699
7Axon guidance_Homo sapiens_hsa043602.22400293
8Proteoglycans in cancer_Homo sapiens_hsa052052.17404287
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.07102354
10Notch signaling pathway_Homo sapiens_hsa043302.03641274
11Wnt signaling pathway_Homo sapiens_hsa043102.01924939
12TGF-beta signaling pathway_Homo sapiens_hsa043502.00995250
13MicroRNAs in cancer_Homo sapiens_hsa052061.91642676
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90753772
15Dilated cardiomyopathy_Homo sapiens_hsa054141.86199116
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75626405
17Melanogenesis_Homo sapiens_hsa049161.71054223
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69531625
19Small cell lung cancer_Homo sapiens_hsa052221.60944441
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60878689
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57431456
22Colorectal cancer_Homo sapiens_hsa052101.50618705
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50284148
24Cell cycle_Homo sapiens_hsa041101.46681372
25Viral myocarditis_Homo sapiens_hsa054161.41658705
26Pathways in cancer_Homo sapiens_hsa052001.33243678
27Endometrial cancer_Homo sapiens_hsa052131.32150000
28Protein digestion and absorption_Homo sapiens_hsa049741.31108525
29Bladder cancer_Homo sapiens_hsa052191.29310324
30Ovarian steroidogenesis_Homo sapiens_hsa049131.28821865
31p53 signaling pathway_Homo sapiens_hsa041151.26105370
32Amoebiasis_Homo sapiens_hsa051461.25893137
33Lysine degradation_Homo sapiens_hsa003101.25862814
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24197130
35Rap1 signaling pathway_Homo sapiens_hsa040151.23992725
36Tight junction_Homo sapiens_hsa045301.22869280
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22845525
38Chronic myeloid leukemia_Homo sapiens_hsa052201.21766590
39Pancreatic cancer_Homo sapiens_hsa052121.18863753
40Cocaine addiction_Homo sapiens_hsa050301.14909431
41Cardiac muscle contraction_Homo sapiens_hsa042601.14585074
42Renal cell carcinoma_Homo sapiens_hsa052111.10823619
43Prostate cancer_Homo sapiens_hsa052151.10432771
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09021717
45HTLV-I infection_Homo sapiens_hsa051661.06777234
46Glutamatergic synapse_Homo sapiens_hsa047241.05275359
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00656990
48Melanoma_Homo sapiens_hsa052181.00170199
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99457080
50GABAergic synapse_Homo sapiens_hsa047270.98114648
51Glioma_Homo sapiens_hsa052140.96249989
52Malaria_Homo sapiens_hsa051440.96077267
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93827131
54Morphine addiction_Homo sapiens_hsa050320.93067998
55Insulin secretion_Homo sapiens_hsa049110.92342973
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90359313
57ErbB signaling pathway_Homo sapiens_hsa040120.90314480
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88918408
59GnRH signaling pathway_Homo sapiens_hsa049120.88253223
60Estrogen signaling pathway_Homo sapiens_hsa049150.84057727
61Calcium signaling pathway_Homo sapiens_hsa040200.83360457
62Oocyte meiosis_Homo sapiens_hsa041140.82542053
63mTOR signaling pathway_Homo sapiens_hsa041500.82235429
64VEGF signaling pathway_Homo sapiens_hsa043700.81670748
65Thyroid hormone synthesis_Homo sapiens_hsa049180.81567390
66Gap junction_Homo sapiens_hsa045400.80807969
67Gastric acid secretion_Homo sapiens_hsa049710.80144833
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77542151
69Prion diseases_Homo sapiens_hsa050200.76310284
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.75941241
71Dorso-ventral axis formation_Homo sapiens_hsa043200.75713776
72Ras signaling pathway_Homo sapiens_hsa040140.75528124
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74024895
74Nicotine addiction_Homo sapiens_hsa050330.73748925
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73703785
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73673071
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73634796
78Renin secretion_Homo sapiens_hsa049240.73563620
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.72710273
80Thyroid cancer_Homo sapiens_hsa052160.68252764
81Amphetamine addiction_Homo sapiens_hsa050310.68099139
82Dopaminergic synapse_Homo sapiens_hsa047280.67694208
83Taste transduction_Homo sapiens_hsa047420.66341257
84Platelet activation_Homo sapiens_hsa046110.66188182
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.65202622
86Insulin resistance_Homo sapiens_hsa049310.64065028
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.63547175
88AMPK signaling pathway_Homo sapiens_hsa041520.63042853
89FoxO signaling pathway_Homo sapiens_hsa040680.61207824
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60948502
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.60693901
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60658452
93Bile secretion_Homo sapiens_hsa049760.60340352
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57694527
95MAPK signaling pathway_Homo sapiens_hsa040100.55196311
96Shigellosis_Homo sapiens_hsa051310.54026199
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53331612
98Hepatitis B_Homo sapiens_hsa051610.53130202
99Oxytocin signaling pathway_Homo sapiens_hsa049210.52932259
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52169328
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51778687
102Insulin signaling pathway_Homo sapiens_hsa049100.51127675
103Circadian rhythm_Homo sapiens_hsa047100.51071558
104Choline metabolism in cancer_Homo sapiens_hsa052310.50408205
105Long-term potentiation_Homo sapiens_hsa047200.50287121
106Prolactin signaling pathway_Homo sapiens_hsa049170.50082229
107Salivary secretion_Homo sapiens_hsa049700.49723384
108Non-small cell lung cancer_Homo sapiens_hsa052230.48617010
109Serotonergic synapse_Homo sapiens_hsa047260.47312430
110Propanoate metabolism_Homo sapiens_hsa006400.45978658
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44805919
112Endocytosis_Homo sapiens_hsa041440.43816642
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43688282
114cAMP signaling pathway_Homo sapiens_hsa040240.41356834
115Viral carcinogenesis_Homo sapiens_hsa052030.40923198
116Toxoplasmosis_Homo sapiens_hsa051450.40070161
117Long-term depression_Homo sapiens_hsa047300.39686595
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39014911
119Pancreatic secretion_Homo sapiens_hsa049720.38797028
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38671514
121Cholinergic synapse_Homo sapiens_hsa047250.38631600
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38550632
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37804237
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.37650563
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37223449
126Circadian entrainment_Homo sapiens_hsa047130.36681309

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